gram positive bacterial infections

Summary

Summary: Infections caused by bacteria that retain the crystal violet stain (positive) when treated by the gram-staining method.

Top Publications

  1. pmc Multiple-drug resistant enterococci: the nature of the problem and an agenda for the future
    M M Huycke
    University of Oklahoma Health Sciences Center 73190, USA
    Emerg Infect Dis 4:239-49. 1998
  2. ncbi Nosocomial bloodstream infections in US hospitals: analysis of 24,179 cases from a prospective nationwide surveillance study
    Hilmar Wisplinghoff
    Department of Internal Medicine, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, USA
    Clin Infect Dis 39:309-17. 2004
  3. ncbi SHEA guideline for preventing nosocomial transmission of multidrug-resistant strains of Staphylococcus aureus and enterococcus
    Carlene A Muto
    Division of Hospital Epidemiology and Infection Control, UPMC P, Pittsburgh, Pennsylvania 15213, USA
    Infect Control Hosp Epidemiol 24:362-86. 2003
  4. ncbi Bacteremias: a leading cause of death
    Gonzalo M L Bearman
    Internal Medicine, Epidemiology and Community Medicine, Division of Quality HealthCare, Virginia Commonwealth University Medical Center, Richmond, Virginia 23298 0019, USA
    Arch Med Res 36:646-59. 2005
  5. ncbi Induction of toll-like receptors by Propionibacterium acnes
    S Jugeau
    INSERM U601, CHU, Pl A Ricordeau, 44095 Nantes, France
    Br J Dermatol 153:1105-13. 2005
  6. ncbi Vancomycin-resistant enterococci: why are they here, and where do they come from?
    M J Bonten
    Department of Internal Medicine and the Eijkman Winkler Institute for Microbiology, Infectious Diseases, and Inflammation, University Medical Center Utrecht, The Netherlands
    Lancet Infect Dis 1:314-25. 2001
  7. ncbi The Enterococcus faecalis cytolysin: a novel toxin active against eukaryotic and prokaryotic cells
    Phillip S Coburn
    Department of Microbiology and Immunology, Stanton L Young Biomedical Research Center, Rm 356, The University of Oklahoma Health Sciences Center, PO Box 26901, Oklahoma City, OK 73190, USA
    Cell Microbiol 5:661-9. 2003
  8. pmc Contribution of gelatinase, serine protease, and fsr to the pathogenesis of Enterococcus faecalis endophthalmitis
    Michael Engelbert
    Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    Infect Immun 72:3628-33. 2004
  9. ncbi Transfer of vancomycin-resistant enterococci via health care worker hands
    Amy N Duckro
    Department of Internal Medicine, Section of Infectious Diseases, Rush University Medical Center, Chicago, IL 60612, USA
    Arch Intern Med 165:302-7. 2005
  10. ncbi Glycopeptide resistance in enterococci
    M Arthur
    Unite des Agents Antibacteriens, Centre National de la Recherche Scientifique, EP J0058, Institut Pasteur, Paris, France
    Trends Microbiol 4:401-7. 1996

Detail Information

Publications246 found, 100 shown here

  1. pmc Multiple-drug resistant enterococci: the nature of the problem and an agenda for the future
    M M Huycke
    University of Oklahoma Health Sciences Center 73190, USA
    Emerg Infect Dis 4:239-49. 1998
    ..Equally important is renewed vigor in the search for additional drugs, accompanied by the evolution of new therapeutic paradigms less vulnerable to the cycle of drug introduction and drug resistance...
  2. ncbi Nosocomial bloodstream infections in US hospitals: analysis of 24,179 cases from a prospective nationwide surveillance study
    Hilmar Wisplinghoff
    Department of Internal Medicine, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, USA
    Clin Infect Dis 39:309-17. 2004
    ..Nosocomial bloodstream infections (BSIs) are important causes of morbidity and mortality in the United States...
  3. ncbi SHEA guideline for preventing nosocomial transmission of multidrug-resistant strains of Staphylococcus aureus and enterococcus
    Carlene A Muto
    Division of Hospital Epidemiology and Infection Control, UPMC P, Pittsburgh, Pennsylvania 15213, USA
    Infect Control Hosp Epidemiol 24:362-86. 2003
    ..After 2 more years without improvement, a SHEA task force was appointed to draft this evidence-based guideline on preventing nosocomial transmission of such pathogens, focusing on the two considered most out of control: MRSA and VRE...
  4. ncbi Bacteremias: a leading cause of death
    Gonzalo M L Bearman
    Internal Medicine, Epidemiology and Community Medicine, Division of Quality HealthCare, Virginia Commonwealth University Medical Center, Richmond, Virginia 23298 0019, USA
    Arch Med Res 36:646-59. 2005
    ..Regrettably, despite advances in treatment and intensive care facilities, mortality remains high...
  5. ncbi Induction of toll-like receptors by Propionibacterium acnes
    S Jugeau
    INSERM U601, CHU, Pl A Ricordeau, 44095 Nantes, France
    Br J Dermatol 153:1105-13. 2005
    ..Recent studies have found that keratinocytes express toll-like receptors (TLRs) implicated in immediate immunity. No studies have, to date, been carried out on the action of P. acnes upon TLR activation in keratinocytes...
  6. ncbi Vancomycin-resistant enterococci: why are they here, and where do they come from?
    M J Bonten
    Department of Internal Medicine and the Eijkman Winkler Institute for Microbiology, Infectious Diseases, and Inflammation, University Medical Center Utrecht, The Netherlands
    Lancet Infect Dis 1:314-25. 2001
    ....
  7. ncbi The Enterococcus faecalis cytolysin: a novel toxin active against eukaryotic and prokaryotic cells
    Phillip S Coburn
    Department of Microbiology and Immunology, Stanton L Young Biomedical Research Center, Rm 356, The University of Oklahoma Health Sciences Center, PO Box 26901, Oklahoma City, OK 73190, USA
    Cell Microbiol 5:661-9. 2003
    ....
  8. pmc Contribution of gelatinase, serine protease, and fsr to the pathogenesis of Enterococcus faecalis endophthalmitis
    Michael Engelbert
    Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    Infect Immun 72:3628-33. 2004
    ..This increased attenuation suggests that there are possible additional pleiotropic effects of the defect in fsr on expression of traits contributing to the pathogenesis of enterococcal infection...
  9. ncbi Transfer of vancomycin-resistant enterococci via health care worker hands
    Amy N Duckro
    Department of Internal Medicine, Section of Infectious Diseases, Rush University Medical Center, Chicago, IL 60612, USA
    Arch Intern Med 165:302-7. 2005
    ..We sought to determine the frequency of VRE transmission from sites in the environment or on patients' intact skin to clean environmental or skin sites via contaminated hands of HCWs during routine care...
  10. ncbi Glycopeptide resistance in enterococci
    M Arthur
    Unite des Agents Antibacteriens, Centre National de la Recherche Scientifique, EP J0058, Institut Pasteur, Paris, France
    Trends Microbiol 4:401-7. 1996
    ....
  11. ncbi A classification system for plasmids from enterococci and other Gram-positive bacteria
    L B Jensen
    National Food Institute, DTU, Division of Microbiology and Risk Assessment, Bulowsvej 27, DK 1790 Copenhagen V, Denmark
    J Microbiol Methods 80:25-43. 2010
    ..Among them 19 gave no positive amplicons indicating presence of rep-families not tested for in this experimental setup...
  12. ncbi Determination of the toxic potential of Bacillus cereus isolates by quantitative enterotoxin analyses
    Maximilian Moravek
    Institute for Hygiene and Technology of Food of Animal Origin, Veterinary Faculty, University of Munich, Oberschleissheim, Germany
    FEMS Microbiol Lett 257:293-8. 2006
    ..cereus. In particular, the level of Nhe seems to explain most of the cytotoxic activity of B. cereus isolates and may indicate a highly diarrheic potential...
  13. pmc VanA-type enterococci from humans, animals, and food: species distribution, population structure, Tn1546 typing and location, and virulence determinants
    F Biavasco
    Institute of Microbiology and Biomedical Sciences, Polytechnic University of Marche, Via Ranieri, Monte D Ago, 60131 Ancona, Italy
    Appl Environ Microbiol 73:3307-19. 2007
    ....
  14. ncbi Clinical relevance of bacteriostatic versus bactericidal mechanisms of action in the treatment of Gram-positive bacterial infections
    G A Pankey
    Section of Infectious Diseases, Ochsner Clinic Foundation, New Orleans, Louisiana 70121 2483, USA
    Clin Infect Dis 38:864-70. 2004
    ..The ultimate guide to treatment of any infection must be clinical outcome...
  15. ncbi Role of mobile DNA in the evolution of vancomycin-resistant Enterococcus faecalis
    I T Paulsen
    Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA
    Science 299:2071-4. 2003
    ..The apparent propensity for the incorporation of mobile elements probably contributed to the rapid acquisition and dissemination of drug resistance in the enterococci...
  16. pmc Emergence of vancomycin-resistant enterococci
    L B Rice
    VA Medical Center and Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
    Emerg Infect Dis 7:183-7. 2001
    ..Control of VRE will require better understanding of the mechanisms by which different classes of drugs promote gastrointestinal colonization...
  17. pmc Characterization of fsr, a regulator controlling expression of gelatinase and serine protease in Enterococcus faecalis OG1RF
    X Qin
    Division of Infectious Diseases, Department of Medicine, University of Texas Medical School, Houston, TX 77030, USA
    J Bacteriol 183:3372-82. 2001
    ....
  18. pmc Antecedent treatment with different antibiotic agents as a risk factor for vancomycin-resistant Enterococcus
    Yehuda Carmeli
    Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    Emerg Infect Dis 8:802-7. 2002
    ..Vancomycin was not a risk factor for isolation of VRE...
  19. pmc Characterizing an outbreak of vancomycin-resistant enterococci using hidden Markov models
    E S McBryde
    School of Mathematical Sciences, Queensland University of Technology, Brisbane, Queensland 4001, Australia
    J R Soc Interface 4:745-54. 2007
    ..Genotyping is commonly used to distinguish epidemic from sporadic vancomycin-resistant enterococci (VRE). We compare this to a statistical method to determine the transmission characteristics of VRE...
  20. ncbi Occurrence and spread of antibiotic resistances in Enterococcus faecium
    Ingo Klare
    Robert Koch Institute, Wernigerode Branch, Burgstrasse 37, D 38855 Wernigerode, Germany
    Int J Food Microbiol 88:269-90. 2003
    ..In order to prevent the dissemination of multiple antibiotic-resistant enterococci or their transferable resistance genes, a prudent use of antibiotics is necessary in human and veterinary medicine, and in animal husbandry...
  21. ncbi Determinants of vancomycin resistance and mortality rates in enterococcal bacteremia. a prospective multicenter study
    E N Vergis
    Division of Infectious Diseases, University of Pittsburgh, Suite 3A, Falk Medical Building, 3601 Fifth Avenue, Pittsburgh, PA 15213, USA
    Ann Intern Med 135:484-92. 2001
    ..21 [CI, 0.06 to 0.80]; P = 0.02). CONCLUSIONS: Vancomycin resistance is an independent predictor of death from enterococcal bacteremia. Early, effective antimicrobial therapy is associated with a significant improvement in survival...
  22. pmc Identification of a novel genomic island specific to hospital-acquired clonal complex 17 Enterococcus faecium isolates
    Esther Heikens
    Department of Medical Microbiology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Appl Environ Microbiol 74:7094-7. 2008
    ..We identified a genomic island in CC17 E. faecium tentatively encoding a metabolic pathway involved in carbohydrate transport and metabolism, which may provide a competitive advantage over the indigenous E. faecium microbiota...
  23. ncbi Reduction in acquisition of vancomycin-resistant enterococcus after enforcement of routine environmental cleaning measures
    Mary K Hayden
    Dept of Medicine and Pathology, Rush University Medical Center, Chicago, IL 60612, USA
    Clin Infect Dis 42:1552-60. 2006
    ..Using vancomycin-resistant enterococci (VRE) as a marker organism, we investigated the effects of improved environmental cleaning with and without promotion of hand hygiene adherence on the spread of VRE in a medical intensive care unit...
  24. ncbi Determining incidence of extended spectrum beta-lactamase producing Enterobacteriaceae, vancomycin-resistant Enterococcus faecium and methicillin-resistant Staphylococcus aureus in 38 centres from 17 countries: the PEARLS study 2001-2002
    S K Bouchillon
    Laboratories International for Microbiology Studies, 2122 Palmer Road, Schaumburg, IL 60173 3817, USA
    Int J Antimicrob Agents 24:119-24. 2004
    ..4% (294/908) and 8.7% (83/949), respectively. PEARLS provides baseline data against which prospective changes in resistant determinants and outcomes can be measured in this ongoing study...
  25. ncbi Outcome of a screening program for vancomycin-resistant enterococci in a hospital in Victoria
    M L Grayson
    Infectious Disease and Clinical Epidemiology Department, Monash Medical Center, Melbourne, Vic
    Med J Aust 171:133-6. 1999
    ..To screen for faecal colonisation with vancomycin-resistant enterococci (VRE) among potentially at-risk patients...
  26. ncbi Biofilm formation by enterococci
    Jamal A Mohamed
    Division of Infectious Diseases, Department of Internal Medicine, University of Texas Medical School, Houston, TX 77030, USA
    J Med Microbiol 56:1581-8. 2007
    ..This review discusses recent advances in knowledge about the biology and genetics of biofilm formation and the role of biofilms in enterococci pathogenesis...
  27. ncbi Daptomycin for the treatment of enterococcal bacteraemia: results from the Cubicin Outcomes Registry and Experience (CORE)
    John F Mohr
    Cubist Pharmaceuticals, Inc, 65 Hayden Avenue, Lexington, MA 02421, USA
    Int J Antimicrob Agents 33:543-8. 2009
    ..Daptomycin may be a useful agent for treating enterococcal bacteraemia caused by E. faecium or E. faecalis. Further studies are warranted...
  28. pmc Molecular characterization of gentamicin-resistant Enterococci in the United States: evidence of spread from animals to humans through food
    S M Donabedian
    Division of Infectious Disease, Department of Medicine, William Beaumont Hospital, Royal Oak, Detroit, Michigan 48073, USA
    J Clin Microbiol 41:1109-13. 2003
    ....
  29. ncbi Low serum procalcitonin level accurately predicts the absence of bacteremia in adult patients with acute fever
    Catherine Chirouze
    Services de Maladies Infectieuses et Tropicales, University Hospital of Besancon, F 25030 Besancon Cedex, France
    Clin Infect Dis 35:156-61. 2002
    ..05). A serum PCT level of <0.4 ng/mL accurately rules out the diagnosis of bacteremia. The use of PCT assessment could help physicians limit the number of blood cultures to be processed and the number of antibiotic prescriptions...
  30. pmc Global spread of vancomycin-resistant Enterococcus faecium from distinct nosocomial genetic complex
    Rob J L Willems
    University Medical Center Utrecht, Utrecht, The Netherlands
    Emerg Infect Dis 11:821-8. 2005
    ..Preventing further spread of this epidemic E. faecium subpopulation is critical, and efforts should focus on the early disclosure of ampicillin-resistant complex-17 strains...
  31. pmc Influence of transferable genetic determinants on the outcome of typing methods commonly used for Enterococcus faecium
    Guido Werner
    Robert Koch Institute, Wernigerode Branch, 38855 Wernigerode, Germany
    J Clin Microbiol 41:1499-506. 2003
    ..Plasmid fingerprints can be included to subdifferentiate enterococcal isolates possessing identical macrorestriction and PCR typing patterns...
  32. ncbi Comparison of mortality associated with vancomycin-resistant and vancomycin-susceptible enterococcal bloodstream infections: a meta-analysis
    Carlos A DiazGranados
    Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA
    Clin Infect Dis 41:327-33. 2005
    ..Whether vancomycin resistance is independently associated with mortality among patients with enterococcal bloodstream infection (BSI) is controversial. To address this issue, we performed a systematic literature review with meta-analysis...
  33. pmc DNA banding pattern polymorphism in vancomycin-resistant Enterococcus faecium and criteria for defining strains
    D Morrison
    Laboratory of Hospital Infection, Central Public Health Laboratory, London, United Kingdom
    J Clin Microbiol 37:1084-91. 1999
    ..This study demonstrates the high degree of DNA banding pattern polymorphism found for some strains of VREM and illustrates the complexity involved in defining such strains...
  34. pmc Prophylactic and therapeutic efficacy of antibodies to a capsular polysaccharide shared among vancomycin-sensitive and -resistant enterococci
    J Huebner
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Infect Immun 68:4631-6. 2000
    ..These data indicate that CP antigens from enterococci are potential targets of protective antibodies and that these antibodies may be useful for prophylaxis and treatment of enterococcal infections...
  35. pmc The enterococcal surface protein, Esp, is involved in Enterococcus faecalis biofilm formation
    A Toledo-Arana
    , , Campus de Arrosadia, 31006 Pamplona, Spain
    Appl Environ Microbiol 67:4538-45. 2001
    ..faecalis isolates, (ii) the biofilm formation capacity is restricted to the E. faecalis strains harboring esp, and (iii) Esp promotes primary attachment and biofilm formation of E. faecalis on abiotic surfaces...
  36. ncbi Spread of ampicillin/vancomycin-resistant Enterococcus faecium of the epidemic-virulent clonal complex-17 carrying the genes esp and hyl in German hospitals
    I Klare
    Robert Koch Institute, Wernigerode Branch, Burgstr 37, 38855, Wernigerode, Germany
    Eur J Clin Microbiol Infect Dis 24:815-25. 2005
    ..In conclusion, it is very important to monitor the occurrence of epidemic-virulent clonal complex-17 strains of E. faecium to prevent their spread in hospitals, especially if they are resistant to glycopeptides and linezolid...
  37. pmc Multilocus sequence typing scheme for Enterococcus faecium
    Wieger L Homan
    Research Laboratory for Infectious Diseases, National Institute of Public Health and the Environment, Bilthoven, The Netherlands
    J Clin Microbiol 40:1963-71. 2002
    ..The results show that MLST of E. faecium provides an excellent tool for isolate characterization and long-term epidemiologic analysis...
  38. ncbi Occurrence of co-colonization or co-infection with vancomycin-resistant enterococci and methicillin-resistant Staphylococcus aureus in a medical intensive care unit
    David K Warren
    Division of Infectious Diseases, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Infect Control Hosp Epidemiol 25:99-104. 2004
    ..To determine the occurrence of co-colonization or co-infection with VRE and MRSA among medical patients requiring intensive care...
  39. ncbi The impact of persistent gastrointestinal colonization on the transmission dynamics of vancomycin-resistant enterococci
    Erika M C D'Agata
    Department of Medicine, Division of Infectious Diseases, School of Medicine, Vanderbilt University, Nashville, Tennessee, USA
    J Infect Dis 185:766-73. 2002
    ..Decreasing the duration of colonization, limiting hospital acquisition of VRE, and improving compliance with hand hygiene in the hemodialysis unit may decrease the rapidly rising rates of VRE in the patient population...
  40. ncbi Daptomycin-resistant Enteroccoccus faecium in a patient with no prior exposure to daptomycin
    M H Fraher
    J Hosp Infect 65:376-8. 2007
  41. ncbi Emergence of resistance to daptomycin during treatment of vancomycin-resistant Enterococcus faecalis infection
    L Silvia Munoz-Price
    Clin Infect Dis 41:565-6. 2005
  42. pmc De novo daptomycin nonsusceptibility in a clinical isolate
    Emil P Lesho
    J Clin Microbiol 44:673. 2006
  43. pmc Population structure of Enterococcus faecium causing bacteremia in a Spanish university hospital: setting the scene for a future increase in vancomycin resistance?
    Teresa M Coque
    Departamento de Microbiologíca, Servicio de Microbiologia, Hospital Universitario Ramon y Cajal, Carretera de Colmenar, Km 9 1, Madrid 28034, Spain
    Antimicrob Agents Chemother 49:2693-700. 2005
    ..001). These findings reflect the importance of local environmental differences in the evolution of this CC, suggesting that the emergence of vancomycin resistance among AREF strains in Spain may be a question of time...
  44. ncbi Linezolid for the treatment of multidrug-resistant, gram-positive infections: experience from a compassionate-use program
    Mary C Birmingham
    CPL Associates, University at Buffalo, New York, USA
    Clin Infect Dis 36:159-68. 2003
    ..1% of cases), and cutaneous reactions (4.0% of cases). Linezolid provided high rates of clinical cure and microbiological success in this complicated patient population, with very good overall tolerance...
  45. ncbi Linezolid: the first oxazolidinone antimicrobial
    Robert C Moellering
    Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Ann Intern Med 138:135-42. 2003
    ..The drug has an acceptable profile of adverse events, but reversible myelosuppression has occurred in patients receiving high doses for more than 2 weeks...
  46. ncbi Association between resistance to vancomycin and death in cases of Enterococcus faecium bacteremia
    J M Garbutt
    Division of General Medical Sciences, Washington University School of Medicine, St Louis, MO 63110, USA
    Clin Infect Dis 30:466-72. 2000
    ..74; 95% confidence interval, 0.5-6.12; P=.39). Vancomycin resistance does not independently increase mortality among patients with E. faecium bacteremia...
  47. ncbi Prevalence of resistance to ampicillin, gentamicin and vancomycin in Enterococcus faecalis and Enterococcus faecium isolates from clinical specimens and use of antimicrobials in five Nordic hospitals
    G S Simonsen
    University of Tromsø and University Hospital of North Norway UNN, Norway
    J Antimicrob Chemother 51:323-31. 2003
    ..faecalis isolates. This indicates a potential for further improvement of antibiotic policies, and possibly hospital infection control, to maintain the low resistance levels observed in these countries...
  48. pmc Emergence of linezolid resistance in the vancomycin-resistant Enterococcus faecium multilocus sequence typing C1 epidemic lineage
    Maria Grazia Bonora
    Dipartimento di Patologia, Sezione di Microbiologia, Universita di Verona, Strada Le Grazie 8, 37100 Verona, Italy
    J Clin Microbiol 44:1153-5. 2006
    ..Linezolid-resistant isolates carried the G2576T mutation in the 23S rRNA gene, belonged to different clones, and shared the same allelic profile, which clusters in the C1 multilocus sequence typing epidemic lineage...
  49. ncbi Risk factors associated with the development of infection with linezolid- and vancomycin-resistant Enterococcus faecium
    Manjunath P Pai
    College of Pharmacy, University of New Mexico, Albuquerque, NM, USA
    Clin Infect Dis 35:1269-72. 2002
    ..These strains of E. faecium were resistant to the entire class of oxazolidinones...
  50. ncbi [Prevention and control of the spread of vancomycin-resistant enterococci: results of a workshop held by the German Society for Hygiene and Microbiology]
    R P Vonberg
    Institut für Medizinische Mikrobiologie und Krankenhaushygiene, Medizinische Hochschule, Carl Neuberg Str 1, 30625, Hannover, Deutschland
    Anaesthesist 56:151-7. 2007
    ....
  51. ncbi Epidemiological, microbiological, clinical, and prognostic factors of bacteremia caused by high-level vancomycin-resistant Enterococcus species
    V Peset
    Microbiology Department, Hospital Universitario La Fe de Valencia, Spain
    Eur J Clin Microbiol Infect Dis 19:742-9. 2000
    ..This is believed to be the first and only such outbreak described in a Spanish hospital thus far...
  52. pmc Convenient selective differential broth for isolation of vancomycin-resistant enterococcus from fecal material
    Thomas J Novicki
    Department of Laboratory Medicine, University of Washington, Seattle, Washington 98195 7110, USA
    J Clin Microbiol 42:1637-40. 2004
    ..We have thus developed an easily prepared vancomycin selective differential broth that is significantly more sensitive and specific in the detection of VRE than is direct fecal plating to BEA agar...
  53. ncbi Linezolid compared with teicoplanin for the treatment of suspected or proven Gram-positive infections
    Mark Wilcox
    Department of Microbiology, Leeds General Infirmary and University of Leeds Teaching Hospitals, Old Medical School, Leeds LS1 3EX
    J Antimicrob Chemother 53:335-44. 2004
    ..However, antibiotic discontinuation rates as a result of drug related adverse events were similar (4.7% in the linezolid group versus 3.7%). Linezolid was clinically superior to teicoplanin in the treatment of Gram-positive infections...
  54. pmc Vancomycin-resistant enterococci outside the health-care setting: prevalence, sources, and public health implications
    L C McDonald
    Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Emerg Infect Dis 3:311-7. 1997
    ..If transmission with VRE from unrecognized community sources can be identified and controlled, increased incidence of colonization and infection among hospitalized patients may be prevented...
  55. ncbi Measurement of ampicillin, vancomycin, linezolid and gentamicin activity against enterococcal biofilms
    Jonathan A T Sandoe
    Department of Microbiology, The General Infirmary at Leeds, UK
    J Antimicrob Chemother 57:767-70. 2006
    ..We measured an alternative endpoint, the minimum biofilm inhibitory concentration (MBIC) and compared the results with MIC and MBC...
  56. ncbi Clinical and epidemiological features of Enterococcus casseliflavus/flavescens and Enterococcus gallinarum bacteremia: a report of 20 cases
    K C Reid
    Division of Infectious Diseases, Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Clin Infect Dis 32:1540-6. 2001
    ..Polymicrobial bacteremia was present in 9 patients (45%). E. gallinarum and E. casseliflavus/flavescens, although they are infrequently isolated from clinical specimens, may cause serious invasive infections...
  57. ncbi Nosocomial transmission of vancomycin-resistant enterococci from surfaces
    Amy J Ray
    JAMA 287:1400-1. 2002
  58. ncbi Efficacy and safety of tigecycline compared with vancomycin or linezolid for treatment of serious infections with methicillin-resistant Staphylococcus aureus or vancomycin-resistant enterococci: a Phase 3, multicentre, double-blind, randomized study
    I Florescu
    Emergency Clinical Hospital, Bucharest, Romania
    J Antimicrob Chemother 62:i17-28. 2008
    ..Methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE) are causing serious nosocomial infections. Tigecycline was evaluated in hospitalized patients with MRSA or VRE infection...
  59. ncbi European survey of vancomycin-resistant enterococci in at-risk hospital wards and in vitro susceptibility testing of ramoplanin against these isolates
    Herman Goossens
    University Hospital Antwerp and Belgian Reference Centre of Enterococci, Edegem, Belgium
    J Antimicrob Chemother 51:iii5-12. 2003
    ..This survey suggests that in some centres in Europe, a similar situation may be encountered to that in the USA (monoclonal spread of multi-resistant VRE in at-risk wards)...
  60. ncbi Colonization with vancomycin-resistant enterococci in chronic hemodialysis patients
    M C Roghmann
    University of Maryland School of Medicine, Baltimore, USA
    Am J Kidney Dis 32:254-7. 1998
    ..This suggests that VRE transmission occurs predominantly in the inpatient setting...
  61. ncbi Substantially increased faecal carriage of vancomycin-resistant enterococci in a tertiary Greek hospital after a 4 year time interval
    D Sofianou
    Department of Microbiology, Hippokration University Hospital, Thessaloniki, Greece
    J Antimicrob Chemother 54:251-4. 2004
    ....
  62. ncbi Implications of colonization of vancomycin-resistant enterococci (VRE) in renal dialysis patients. Learning to live with it?
    H Humphreys
    Department of Clinical Microbiology, Royal College of Surgeons in Ireland, Dublin, Ireland
    J Hosp Infect 58:28-33. 2004
    ....
  63. pmc Dispersion of multidrug-resistant Enterococcus faecium isolates belonging to major clonal complexes in different Portuguese settings
    Ana R Freitas
    REQUIMTE, Laboratorio de Microbiologia, Faculdade de Farmacia, Universidade do Porto, Porto, Portugal
    Appl Environ Microbiol 75:4904-8. 2009
    ..Our findings highlight the role of community-associated hosts as reservoirs of enterococci able to cause human infections...
  64. ncbi The analysis of hospital infection data using hidden Markov models
    Ben Cooper
    Department of Epidemiology, Kresge Building, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
    Biostatistics 5:223-37. 2004
    ..Compared to the standard hidden Markov model, the new approach is more parsimonious, is more biologically plausible, and allows key epidemiological parameters to be estimated...
  65. ncbi Evaluation of the prevalence and risk factors for colonization by vancomycin-resistant Enterococcus among patients on dialysis
    Dulce Barbosa
    Department of Nursing, Division of Nursing in Infectology, Federal University of Sao Paulo, Escola Paulista de Medicina, Sao Paulo, Brazil
    Am J Kidney Dis 44:337-43. 2004
    ..This study aims to appraise the prevalence and risk factors for VRE colonization among patients on long-term dialysis therapy, as well as the mechanisms for dissemination of vancomycin resistance...
  66. ncbi Vancomycin-resistant enterococci colonization in patients at seven hemodialysis centers
    J I Tokars
    Hospital Infections Program, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Kidney Int 60:1511-6. 2001
    ..We studied the prevalence of and risk factors for VRE at seven outpatient hemodialysis centers (three in Baltimore, MD, USA, and four in Richmond, VA, USA)...
  67. ncbi Linezolid-resistant, vancomycin-resistant Enterococcus faecium infection in patients without prior exposure to linezolid
    Sibtain Rahim
    Division of Infectious Diseases, New York University Medical Center, New York, NY, USA
    Clin Infect Dis 36:E146-8. 2003
    ..Nosocomial transmission of LRVREF is an ominous sign and underscores the importance of meticulous infection-control measures...
  68. ncbi Taxonomic study of Weissella confusa and description of Weissella cibaria sp. nov., detected in food and clinical samples
    K Johanna Björkroth
    Department of Food and Environmental Hygiene, Faculty of Veterinary Medicine, University of Helsinki, Finland
    Int J Syst Evol Microbiol 52:141-8. 2002
    ..Based on whole-cell protein electrophoresis, and ClaI and HindIII ribotyping patterns, food and clinical isolates were randomly located in the two species-specific clusters obtained...
  69. pmc Molecular characterization of ampicillin-resistant Enterococcus faecium isolates from hospitalized patients in Norway
    Roland Jureen
    Institute of Medicine, University of Bergen, Bergen, Norway
    J Clin Microbiol 41:2330-6. 2003
    ..Rectal and clinical isolates were generally indistinguishable, and differences in clonal distribution and allele polymorphism were found mainly between ampicillin-resistant and -susceptible isolates...
  70. ncbi Control of nosocomial acquisition of vancomycin-resistant Enterococcus through active surveillance of hemodialysis patients
    R Neal Axon
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Infect Control Hosp Epidemiol 25:436-8. 2004
    ..05). To assess the effectiveness of active surveillance, patients undergoing active surveillance should be analyzed separately from other patients...
  71. ncbi A prospective incidence study of nosocomial infections in a neonatal care unit
    Mireya Urrea
    Quality Service Infection Hospital Program, Hospital Sant Joan de Deu de Barcelona, Barcelona, Spain
    Am J Infect Control 31:505-7. 2003
    ..However, nosocomial infections (NI) still represent an important cause of morbidity and mortality in this population...
  72. ncbi Hospital-acquired vancomycin-resistant enterococci: now appearing in Kuala Lumpur Hospital
    A W Zubaidah
    Department of Pathology, Kuala Lumpur Hospital
    Med J Malaysia 61:487-9. 2006
    ..The microbiology laboratory plays an important role in the identification and detection of VRE...
  73. pmc Nosocomial spread of Enterococcus faecium resistant to vancomycin and linezolid in a tertiary care medical center
    Thomas E Dobbs
    Department of Medicine, University of Alabama at Birmingham, 619 South 19th St, 35249, USA
    J Clin Microbiol 44:3368-70. 2006
    ..Epidemiologic investigation and pulsed-field gel electrophoresis patterns indicated a clonal outbreak related to nosocomial spread...
  74. ncbi Bacillus cereus central line infection in an immunocompetent child with hemophilia
    Poyyapakkam R Srivaths
    Tulane University School of Medicine, Huey P Long Medical Center, Department of Pediatrics, New Orleans, Louisiana, USA
    J Pediatr Hematol Oncol 26:194-6. 2004
    ..The authors report a case of Bacillus cereus infection of a central line in an immunocompetent patient with hemophilia, which required line removal for complete cure...
  75. ncbi Costs and savings associated with infection control measures that reduced transmission of vancomycin-resistant enterococci in an endemic setting
    M A Montecalvo
    Division of Infectious Diseases, New York Medical College, Valhalla 10595, USA
    Infect Control Hosp Epidemiol 22:437-42. 2001
    ....
  76. ncbi Effects of daptomycin in combination with other antimicrobial agents: a review of in vitro and animal model studies
    Judith N Steenbergen
    Cubist Pharmaceuticals Inc, Lexington, MA 02421, USA
    J Antimicrob Chemother 64:1130-8. 2009
    ..e. osteomyelitis and implant infections, where rifampicin combinations with daptomycin increased efficacy and reduced the incidence of rifampicin resistance...
  77. ncbi Increasing rates of vancomycin resistance among Enterococcus faecium isolated from German hospitals between 2004 and 2006 are due to wide clonal dissemination of vancomycin-resistant enterococci and horizontal spread of vanA clusters
    Guido Werner
    Robert Koch Institute, Wernigerode Branch, D 38855 Wernigerode, Germany
    Int J Med Microbiol 298:515-27. 2008
    ..In conclusion, the increase in the rates of VREF among German hospital patients within the last 2 years might be rather complex and due to different molecular events and scenarios...
  78. ncbi Vancomycin-resistant enterococci among chronic hemodialysis patients: a prospective study of acquisition
    E M D'Agata
    Department of Medicine, Division of Infectious Diseases, Vanderbilt University School of Medicine, Nashville, TN 37232 2605, USA
    Clin Infect Dis 32:23-9. 2001
    ..Hospital acquisition of VRE contributes substantially to the increasing prevalence of VRE in the chronic hemodialysis patient population...
  79. ncbi Vancomycin-resistant enterococcal colonization and infection in liver transplant candidates and recipients: a prospective surveillance study
    Shelly A McNeil
    Division of Infectious Diseases, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, Michigan, USA
    Clin Infect Dis 42:195-203. 2006
    ..We performed a prospective study among patients awaiting transplantation to assess rates, risk factors, and outcomes associated with VRE colonization before and after transplantation...
  80. ncbi Modulation of virulence within a pathogenicity island in vancomycin-resistant Enterococcus faecalis
    Nathan Shankar
    of Pharmaceutical Sciences, University of Oklahoma Health Sciences Center, PO Box 26901, Oklahoma City, Oklahoma 73190, USA
    Nature 417:746-50. 2002
    ....
  81. pmc 16S ribosomal DNA sequence-based analysis of clinically significant gram-positive anaerobic cocci
    Yuli Song
    Research Service Clinical Microbiology Laboratory, VA Medical Center West Los Angeles, California 90073, USA
    J Clin Microbiol 41:1363-9. 2003
    ..This finding is in contrast to the phenotypic identification results, by which only 56% of isolates were correctly identified to species level...
  82. ncbi Bacteremia in febrile Malawian children: clinical and microbiologic features
    A L Walsh
    Wellcome Trust Research Laboratories, University of Malawi, Blantyre
    Pediatr Infect Dis J 19:312-8. 2000
    ..There are no published data for the incidence or etiology of childhood bacteremia in Malawi. We describe the clinical and microbiologic features of children admitted to hospital from whom blood cultures yielded bacterial pathogens...
  83. pmc Influence of origin of isolates, especially endocarditis isolates, and various genes on biofilm formation by Enterococcus faecalis
    Jamal A Mohamed
    Division of Infectious Diseases, Department of Internal Medicine, University of Texas Medical School, Houston, Texas 77030, USA
    Infect Immun 72:3658-63. 2004
    ..faecalis regulator) [corrected] resulted in fewer attached bacteria, as determined using phase-contrast microscopy, and less biofilm (P < 0.0001)...
  84. pmc Vancomycin-resistant enterococci in intensive-care hospital settings: transmission dynamics, persistence, and the impact of infection control programs
    D J Austin
    Wellcome Trust Centre for the Epidemiology of Infectious Disease, University of Oxford, South Parks Road, Oxford OX1 3PS, United Kingdom
    Proc Natl Acad Sci U S A 96:6908-13. 1999
    ..Our analyses suggest that compliance for hand washing significantly in excess of reported levels, or the cohorting of nursing staff, are needed to prevent nosocomial transmission of VRE in endemic settings...
  85. ncbi Lipoprotein biogenesis in Gram-positive bacteria: knowing when to hold 'em, knowing when to fold 'em
    Matthew I Hutchings
    School of Biological Sciences, University of East Anglia, Norwich, NR4 7TJ, UK
    Trends Microbiol 17:13-21. 2009
    ..Here, we review recent discoveries concerning the export and processing of these proteins, their role in virulence in Gram-positive bacteria and their potential as vaccine candidates or targets for new antimicrobials...
  86. ncbi Propionibacterium acnes associated with inflammation in radical prostatectomy specimens: a possible link to cancer evolution?
    Ronald J Cohen
    Uropath Pty Ltd, Perth, Western Australia
    J Urol 173:1969-74. 2005
    ..The etiology of prostatic inflammation is unknown. However, the involvement of a carcinogenic infectious agent has been suggested...
  87. pmc Role of Enterococcus faecalis surface protein Esp in the pathogenesis of ascending urinary tract infection
    N Shankar
    Department of Pharmaceutical Sciences, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73190, USA
    Infect Immun 69:4366-72. 2001
    ..We conclude that, while Esp does not influence histopathological changes associated with acute urinary tract infections, it contributes to colonization and persistence of E. faecalis at this site...
  88. pmc Multilocus sequence typing scheme for bacteria of the Bacillus cereus group
    Erlendur Helgason
    Biotechnology Centre of Oslo and School of Pharmacy, Oslo, Norway
    Appl Environ Microbiol 70:191-201. 2004
    ..anthracis isolates analyzed had the same ST. The MLST scheme which we developed has a high level of resolution and should be an excellent tool for studying the population structure and epidemiology of the B. cereus group...
  89. ncbi Antibiotic-resistant enterococci: the mechanisms and dynamics of drug introduction and resistance
    Brett D Shepard
    Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, 975 NE 10th St, BRC 356, Oklahoma City, Oklahoma, USA
    Microbes Infect 4:215-24. 2002
    ..This review summarizes current concepts regarding the mechanisms of resistance, as well as the emergence, proliferation, and epidemiology of resistant enterococci...
  90. ncbi Daptomycin: another novel agent for treating infections due to drug-resistant gram-positive pathogens
    Christopher F Carpenter
    Division of Infectious Diseases, William Beaumont Hospital, Royal Oak, Michigan, USA
    Clin Infect Dis 38:994-1000. 2004
    ..The rapid bactericidal activity, low potential for resistance, and promising safety profile associated with this agent will make it a useful addition to our growing armamentarium of antibiotics active against gram-positive pathogens...
  91. ncbi Function of the drosophila pattern-recognition receptor PGRP-SD in the detection of Gram-positive bacteria
    Vincent Bischoff
    Institut de Biologie Moleculaire et Cellulaire, CNRS UPR 9022, 15 rue Rene Descartes, Universite Louis Pasteur, 67084 Strasbourg Cedex, France
    Nat Immunol 5:1175-80. 2004
    ..These data indicate that PGRP-SD can function as a receptor for Gram-positive bacteria and shows partial redundancy with the PGRP-SA-GNBP1 complex...
  92. pmc Characterization of a vancomycin-resistant Enterococcus faecalis (VREF) isolate from a dog with mastitis: further evidence of a clonal lineage of VREF in New Zealand
    Janet M Manson
    Department of Microbiology, Otago School of Medical Sciences, University of Otago, Dunedin, New Zealand
    J Clin Microbiol 41:3331-3. 2003
    ..Comparison of this isolate with VREF from poultry and human sources in New Zealand demonstrated identical SmaI macrorestriction patterns and Tn1546-like elements. This is further evidence of a clonal lineage of VREF in New Zealand...
  93. pmc Emergence of daptomycin resistance in Enterococcus faecium during daptomycin therapy
    James S Lewis
    Antimicrob Agents Chemother 49:1664-5. 2005
  94. pmc Contribution of the collagen adhesin Acm to pathogenesis of Enterococcus faecium in experimental endocarditis
    Sreedhar R Nallapareddy
    Department of Internal Medicine, Division of Infectious Diseases, Center for the Study of Emerging and Re Emerging Pathogens, University of Texas Medical School, Houston, Texas 77030, USA
    Infect Immun 76:4120-8. 2008
    ..faecium collagen adherence by affinity-purified anti-Acm antibodies from E. faecium endocarditis patient sera, suggesting that Acm may be a potential immunotarget for strategies to control this emerging pathogen...
  95. ncbi Microbiological features of vancomycin in the 21st century: minimum inhibitory concentration creep, bactericidal/static activity, and applied breakpoints to predict clinical outcomes or detect resistant strains
    Ronald N Jones
    JMI Laboratories, North Liberty, IA 52317, USA
    Clin Infect Dis 42:S13-24. 2006
    ....
  96. pmc Molecular identification of Leuconostoc mesenteroides as a cause of brain abscess in an immunocompromised patient
    Alessio Albanese
    Department of Neurosurgery, Catholic University of the Sacred Heart, Rome, Italy
    J Clin Microbiol 44:3044-5. 2006
    ..Using molecular methods, we identified Leuconostoc mesenteroides as the cause of a brain abscess which was successfully treated by surgery and antimicrobial treatment. This is the first report of brain abscess caused by this species...
  97. ncbi Identification of glycopeptide-resistant enterococci by VITEK 2 system and conventional and real-time polymerase chain reaction
    Alexandra Eisner
    Institute of Hygiene, Medical University of Graz A 8010, Austria
    Diagn Microbiol Infect Dis 53:17-21. 2005
    ..High specificity and rapidity make the real-time PCR assays superior tools for identification of GRE in clinical samples; however, they do not have the ability to detect vanC...
  98. pmc Multiple-locus variable-number tandem repeat analysis, a novel typing scheme to study the genetic relatedness and epidemiology of Enterococcus faecium isolates
    Janetta Top
    Eijkman Winkler Institute for Microbiology, Infectious Diseases and Inflammation, University Medical Center Utrecht, Utrecht, The Netherlands
    J Clin Microbiol 42:4503-11. 2004
    ..Furthermore, it has the abilities of MLST to recognize genetically related and potential epidemic isolates. Submission of MLVA profiles is possible via a Web-based database for international comparison...
  99. ncbi Reply to Nannini and to a previous letter by Hurley
    Carlos A DiazGranados
    Clin Infect Dis 42:1204-5. 2006
  100. ncbi Increasing prevalence of vancomycin-resistant enterococci, and cefoxitin-, imipenem- and fluoroquinolone-resistant gram-negative bacilli: a KONSAR study in 2002
    Kyungwon Lee
    Department of Laboratory Medicine, Research Institute of Bacterial Resistance, Yonsei University College of Medicine, 134 Shinchon dong, Seodaemun gu, Seoul 120 752, Korea
    Yonsei Med J 45:598-608. 2004
    ..aeruginosa and Acinetobacter spp. increased gradually, and imipenem- resistant E. coli and K. pneumoniae appeared for the first time. Continued surveillance is required to prevent further spread of these serious resistances...
  101. ncbi Endocarditis due to vancomycin-resistant enterococci: case report and review of the literature
    Michael P Stevens
    Virginia Commonwealth University Medical Center, Richmond, VA 23298 0019, USA
    Clin Infect Dis 41:1134-42. 2005
    ..Endocarditis due to vancomycin-resistant enterococci (VRE) is rare, and the literature consists almost exclusively of reports of single cases...

Research Grants57

  1. Elucidating beta-lactamase functional mechanisms via evolutionary conservation
    Dennis R Livesay; Fiscal Year: 2013
    ..As such, we propose a series of additional studies along these lines to expand our understanding of BL structure and function, potentially paving the way to new therapeutic opportunities. ..
  2. Isothermal Titration Calorimeter
    Robert S Hodges; Fiscal Year: 2013
    ..S.) The success of many of these research projects depends on having state-of-the-art equipment to determine binding interactions and structure-function relationships. ..
  3. Antibacterial Resistance Leadership Group (ARLG)
    Vance G Fowler; Fiscal Year: 2013
    ..abstract_text> ..
  4. GENETIC AND CHEMICAL APPROACHES TO NOVEL LIPID II BINDING PEPTIDE ANTIBIOTICS
    Xihou Yin; Fiscal Year: 2010
    ..Understanding the molecular basis of enduracidin resistance in the producing organism will help predict how new antibiotics may be affected by existing resistance mechanisms and provide insight into ways that resistance may emerge. ..
  5. GLYCOPEPTIDE ANTIBOTIC MECHANISM AND RESISTANCE
    TAD KOCH; Fiscal Year: 2001
    ..The research will provide a further understanding of how secondary metabolites of microorganisms are designed to function as antibiotics without being too toxic to the microorganism which creates them. ..
  6. S. mutans: Its mutacin Antibiotic
    Fengxia Qi; Fiscal Year: 2007
    ..mutans. This knowledge will help design effective control measures to curb the growth and virulence of S. mutans in the dental _laque. ..
  7. Catheter Dwell Time and Risk of Bloodstream Infections in Hospitalized Neonates
    Aaron M Milstone; Fiscal Year: 2011
    ..This project will help to develop evidence-based strategies to prevent bloodstream infections among vulnerable infants hospitalized in the neonatal intensive care unit. ..
  8. HUMAN RETROVIRUS-5 AND ARTHRITIS
    Robin Patel; Fiscal Year: 2002
    ..Identification of a specific infectious agent associated with these arthritides would potentially allo for the development of preventive strategies such as vaccination and novel therapeutic approaches. ..
  9. Detection of Biofilm Bacteria using GloBac
    Robin Patel; Fiscal Year: 2008
    ..The goal of the proposed studies is to develop a rapid test for detection of bacteria on artificial joints that can be used in the operating room to diagnose infected artificial joints. [unreadable] [unreadable] [unreadable]..
  10. Enhancement of antimicrobics by electrical current
    Robin Patel; Fiscal Year: 2007
    ..This novel but simple resistance reversing strategy may generalize to a wide variety of antimicrobics and microorganisms and a wide variety of biofilm-associated human infections. [unreadable] [unreadable] [unreadable] [unreadable]..
  11. Transmission Dynamics of Antimocrobial-resistant bacteria in dialysis units
    ERIKA D AGATA; Fiscal Year: 2007
    ..Limiting ARB spread will ultimately reduce infections caused by ARB and improve CHD patient outcomes. [unreadable] [unreadable] [unreadable]..
  12. REGULATION OF NEUTROPHIL OXIDATIVE RESPONSES IN TRAUMA
    Joseph Solomkin; Fiscal Year: 2004
    ..Together, these studies will define potential points for therapeutic intervention and provide important insight into regulation of the acute inflammatory response. ..
  13. Appropriate Pneumococcal Vaccination in Infants in Fiji
    Fiona Russell; Fiscal Year: 2007
    ..The results of this study will form the basis of an effectiveness evaluation following the pilot introduction of pneumococcal immunization into Fiji in 3-5 years time. [unreadable] [unreadable]..
  14. Periodontitis, Atherosclerosis and the Host Response
    Evanthia Lalla; Fiscal Year: 2007
    ..We propose to employ this model to dissect the factors accelerating vascular inflammation and atherosclerosis in periodontitis. ..
  15. BASIC MECHANISMS IN LUNG DISEASE
    Janet Yother; Fiscal Year: 2007
    ..Based on our program's strong record of productivity and its importance in these endeavors, we seek to continue our role in training young investigators for productive careers in pulmonary research. ..
  16. HIV ASSOCIATED NEPHROPATHY IN DRUG ADDICTS
    Pravin Singhal; Fiscal Year: 2007
    ..3. Drugs modulation of the renin-angiotensin system contributes to the progression of renal lesions in mice with HIVAN. [unreadable] [unreadable] [unreadable]..
  17. Pattern Recognition Molecule Mindin As Adjuvant
    You Wen He; Fiscal Year: 2007
    ..Third, Mindin fused DNA plasmids will be examined for their efficacy in protecting influenza virus infection. [unreadable] [unreadable]..
  18. Role of Inter-alpha Inhibitors in Anthrax Intoxication
    Steven Opal; Fiscal Year: 2007
    ..Our research is focused on the development of a new and safe treatment based on the ability of inter-alpha proteins to prevent the fatal consequences of anthrax infection. [unreadable] [unreadable] [unreadable] [unreadable]..
  19. Enterococcus faecium virulence: A molecular and therapeutic approach
    Cesar Arias; Fiscal Year: 2008
    ..A translational approach using the mentor's laboratory established animal models (mouse peritonitis and rat infective endocarditis) will be utilized to explore therapeutic approaches. [unreadable] [unreadable] [unreadable]..
  20. Incidence & Outcomes of SSI After Breast Cancer Surgery
    Margaret Olsen; Fiscal Year: 2008
    ....
  21. Artificial Cornea Based on Photolithographically Patterned, Biomimetic Hydrogels
    Christopher N Ta; Fiscal Year: 2010
    ..3. Determine the skirt design for optimal stromal tissue integration by evaluating in vitro and in vivo stromal wound healing within photolithographically patterned, microperforated hydrogel arrays. ..
  22. Type II secretion system of P. aeruginosa in acute lung infection
    Reuben Ramphal; Fiscal Year: 2010
    ..We wish to examine which of the many known toxins are involved in death and to explore new methods to block secretion of the toxins that may eventually be useful for therapy. ..
  23. Genome Sequencing of Toxoplasma gondii
    Ian Paulsen; Fiscal Year: 2002
    ..gondii research community is solidly behind this effort, and the history of this group (in supporting and successfully exploiting the T. gondii EST project, for example) bodes well for successful utilization of the genomic sequence...
  24. Mechanisms of polysacchairde synthesis by S. pneumoniae
    JANET L YOTHER; Fiscal Year: 2010
    ..The relevance of these properties to the pathogenesis of S. pneumoniae will also be assessed, allowing us to better understand an essential virulence factor of this and many other bacteria. ..
  25. Microbial Correlates of Bacterial Vaginosis Treatment Failure and Recurrence in H
    Michael Ferris; Fiscal Year: 2008
    ..Significance: The results should lead to more effective methods of diagnosing and treating BV, and preventing the serious sequelae associated with this common syndrome. ..
  26. Stopping URIs and FLU in the Family: the Stuffy Trial
    Elaine Larson; Fiscal Year: 2008
    ....
  27. Susceptibility Testing, Treatment Choices, and Outcomes of MDR-GNB Infections
    Lisa Maragakis; Fiscal Year: 2009
    ..This research is designed to better understand how providers use information from various microbiology laboratory testing methods to choose treatments and to identify strategies that lead to the best patient outcomes. ..
  28. Microfluidic system for point of care diagnosis of GBS
    Michel Bergeron; Fiscal Year: 2008
    ..Moreover, this technology could also be applicable to the detection of other infectious disease agents including biological warfare agents. ..
  29. PSEUDOMONAS AERUGINOSA FLAGELLAR BIOGENESIS PATHWAY
    Reuben Ramphal; Fiscal Year: 2007
    ..abstract_text> ..
  30. Antibacterial peptidoglycan recognition proteins
    Roman Dziarski; Fiscal Year: 2007
    ..abstract_text> ..
  31. Extracellular Matrix Protein in Innate Immunity
    You Wen He; Fiscal Year: 2007
    ..Results from this proposal will provide novel insights on the mechanisms of the innate immune response and may have implication for clinical treatment of septic shock and other microbe caused diseases. [unreadable] [unreadable]..
  32. CUTANEOUS ONCOLOGY
    Madeleine Duvic; Fiscal Year: 2004
    ..Young physicians and students who receive advanced training in the proper detection, prevention, and treatment of skin cancers will be a resource and may improve outcomes for patients of the future. ..
  33. LETHAL OROESOPHAGEAL CANDIDIASIS: IMMUNOTHERAPY
    Edward Balish; Fiscal Year: 2004
    ..Restoration and enhancement of immune function may be critical for the effectiveness of anti-Candida vaccines that are now under development. ..
  34. Staff Hand Hygiene and Nosocomial Infections in Neonates
    Elaine Larson; Fiscal Year: 2003
    ....
  35. Gordon Research Conference on Staphylococcal Diseases
    BRIGITTE BERGER BACHI; Fiscal Year: 2003
    ..S. This will afford a unique and rich opportunity for fellowship and scientific exchange between young and established investigators in the field. ..
  36. XYLITOL FOR ACUTE OTITIS MEDIA PROPHYLAXIS
    Louis Vernacchio; Fiscal Year: 2003
    ..A preliminary estimate of the effect size of xylitol treatment from the pilot RCT will suggest whether the effect if sufficiently large to warrant a large formal RCT to be proposed. ..
  37. OCULAR MELANOMA
    Paul Finger; Fiscal Year: 2003
    ..Standardized clinical and data collection procedures will be employed, and standardized forms will be used in all centers. Central training and certification of all study staff will be required. ..
  38. HOME HYGIENE INTERVENTION
    Elaine Larson; Fiscal Year: 2002
    ..Logistic regression, Liang-Zeger regression, and Chi Square analyses will be used to test differences in rates of transmission of symptoms and changes in quantity, types and resistance patterns of microbial flora of the hands. ..
  39. Periodontal microbiota, serum Antibody response & T1DM
    Evanthia Lalla; Fiscal Year: 2002
    ..Theses studies will markedly enhance our understanding of the oral microbiology and immunology in type 1 diabetes. ..
  40. 6th ASM Conference on Streptococcal Genetics
    Janet Yother; Fiscal Year: 2002
    ..The present conference will follow that trend, as we focus on the work of both established and young scientists. ..
  41. Proline uptake in staphylococcus aureus pathogenesis
    WILLIAM SCHWAN; Fiscal Year: 2002
    ..The results of this study will help us understand the role of proline transport in S. aureus infections. ..
  42. FLAGELLIN GLYCOSYLATION AND VIRULENCE OF P. AEROGINOSA
    Reuben Ramphal; Fiscal Year: 2005
    ..The existence of a central gene product involved in these could prove to be of great significance in controlling virulence. ..
  43. FimX in Regulation of Type IV Pili Expression
    Thomas Murray; Fiscal Year: 2005
    ..These studies will determine whether c-diGMP is a second messenger regulating twitching motility in PA. We also will characterize the first ABC transporters identified in PA involved in controlling TFP expression. ..
  44. Chemokines and microglia in Alzheimer's disease
    Joseph El Khoury; Fiscal Year: 2005
    ....
  45. Enterococcus cytolysin: Regulation and structure
    Michael Gilmore; Fiscal Year: 2007
    ..abstract_text> ..
  46. Prevention of Healthcare-Associated Drug-Resistant GNR
    Lisa Maragakis; Fiscal Year: 2006
    ..Maragakis with the skills she needs to develop into an independent clinical investigator in epidemiologic research for the prevention of healthcare-associated infections. ..
  47. ORPHAN NUCLEAR RORgammat IN THYMOCYTE DIFFERENTIATION
    You Wen He; Fiscal Year: 2006
    ..In addition, results from this application will also provide insights for the role of ROR-gamma-t in tumorigenesis. ..
  48. Interdisciplinary Research:Antimicrobial Resistance(RMI)
    Elaine Larson; Fiscal Year: 2006
    ..In the final year, plans for a sustainable Consortium on antimicrobial resistance will be formalized. [unreadable] [unreadable]..
  49. Efficient Mechanism of Gene Transfer in B. fragilis
    David Hecht; Fiscal Year: 2006
    ..abstract_text> ..
  50. Resistant E.coli in Humans and Poultry
    James Johnson; Fiscal Year: 2005
    ..Does the research address a current and compelling problem of antimicrobial resistance that is of high public health importance and for which research is needed? [yes]. ..
  51. Impact of Hand Hygiene Guideline on Infections and Costs
    Elaine Larson; Fiscal Year: 2005
    ..abstract_text> ..
  52. ROLE OF ADHERENCE IN KERATITIS
    Michael Gilmore; Fiscal Year: 2001
    ..abstract_text> ..
  53. OmpR and acid regulation of Escherichia coli fim genes
    WILLIAM SCHWAN; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  54. Legionella pneumophila developmental cycle & virulence
    PAUL STOKES HOFFMAN; Fiscal Year: 2011
    ..These studies should also provide insights relevant to other opportunistic environmental pathogens including oxiella, Burkholderia and species of Mycobacterium. ..
  55. ROLE OF ENDOTHELIN IN PERINATAL PULMONARY VASOREGULATION
    DAVID IVY; Fiscal Year: 2002
    ..Research presentations along with graduate level courses in molecular biology, and the clinical ambiance of the Univ of CO SOM in the area of pulmonary hypertension enhance career development. ..
  56. Pathogen-specific drug targets for weaponized bacteria
    Vincent Fischetti; Fiscal Year: 2007
    ..In total, these efforts target central virulence factors in critical biowarfare pathogens. ..