Genomes and Genes
gram positive bacterial infections
Summary: Infections caused by bacteria that retain the crystal violet stain (positive) when treated by the gram-staining method.
Publications246 found, 100 shown here
- Multiple-drug resistant enterococci: the nature of the problem and an agenda for the futureM M Huycke
University of Oklahoma Health Sciences Center 73190, USA
Emerg Infect Dis 4:239-49. 1998..Equally important is renewed vigor in the search for additional drugs, accompanied by the evolution of new therapeutic paradigms less vulnerable to the cycle of drug introduction and drug resistance...
- Nosocomial bloodstream infections in US hospitals: analysis of 24,179 cases from a prospective nationwide surveillance studyHilmar Wisplinghoff
Department of Internal Medicine, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, USA
Clin Infect Dis 39:309-17. 2004..Nosocomial bloodstream infections (BSIs) are important causes of morbidity and mortality in the United States...
- SHEA guideline for preventing nosocomial transmission of multidrug-resistant strains of Staphylococcus aureus and enterococcusCarlene A Muto
Division of Hospital Epidemiology and Infection Control, UPMC P, Pittsburgh, Pennsylvania 15213, USA
Infect Control Hosp Epidemiol 24:362-86. 2003..After 2 more years without improvement, a SHEA task force was appointed to draft this evidence-based guideline on preventing nosocomial transmission of such pathogens, focusing on the two considered most out of control: MRSA and VRE...
- Bacteremias: a leading cause of deathGonzalo M L Bearman
Internal Medicine, Epidemiology and Community Medicine, Division of Quality HealthCare, Virginia Commonwealth University Medical Center, Richmond, Virginia 23298 0019, USA
Arch Med Res 36:646-59. 2005..Regrettably, despite advances in treatment and intensive care facilities, mortality remains high...
- Induction of toll-like receptors by Propionibacterium acnesS Jugeau
INSERM U601, CHU, Pl A Ricordeau, 44095 Nantes, France
Br J Dermatol 153:1105-13. 2005..Recent studies have found that keratinocytes express toll-like receptors (TLRs) implicated in immediate immunity. No studies have, to date, been carried out on the action of P. acnes upon TLR activation in keratinocytes...
- Vancomycin-resistant enterococci: why are they here, and where do they come from?M J Bonten
Department of Internal Medicine and the Eijkman Winkler Institute for Microbiology, Infectious Diseases, and Inflammation, University Medical Center Utrecht, The Netherlands
Lancet Infect Dis 1:314-25. 2001....
- The Enterococcus faecalis cytolysin: a novel toxin active against eukaryotic and prokaryotic cellsPhillip S Coburn
Department of Microbiology and Immunology, Stanton L Young Biomedical Research Center, Rm 356, The University of Oklahoma Health Sciences Center, PO Box 26901, Oklahoma City, OK 73190, USA
Cell Microbiol 5:661-9. 2003....
- Contribution of gelatinase, serine protease, and fsr to the pathogenesis of Enterococcus faecalis endophthalmitisMichael Engelbert
Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
Infect Immun 72:3628-33. 2004..This increased attenuation suggests that there are possible additional pleiotropic effects of the defect in fsr on expression of traits contributing to the pathogenesis of enterococcal infection...
- Transfer of vancomycin-resistant enterococci via health care worker handsAmy N Duckro
Department of Internal Medicine, Section of Infectious Diseases, Rush University Medical Center, Chicago, IL 60612, USA
Arch Intern Med 165:302-7. 2005..We sought to determine the frequency of VRE transmission from sites in the environment or on patients' intact skin to clean environmental or skin sites via contaminated hands of HCWs during routine care...
- Glycopeptide resistance in enterococciM Arthur
Unite des Agents Antibacteriens, Centre National de la Recherche Scientifique, EP J0058, Institut Pasteur, Paris, France
Trends Microbiol 4:401-7. 1996....
- A classification system for plasmids from enterococci and other Gram-positive bacteriaL B Jensen
National Food Institute, DTU, Division of Microbiology and Risk Assessment, Bulowsvej 27, DK 1790 Copenhagen V, Denmark
J Microbiol Methods 80:25-43. 2010..Among them 19 gave no positive amplicons indicating presence of rep-families not tested for in this experimental setup...
- Determination of the toxic potential of Bacillus cereus isolates by quantitative enterotoxin analysesMaximilian Moravek
Institute for Hygiene and Technology of Food of Animal Origin, Veterinary Faculty, University of Munich, Oberschleissheim, Germany
FEMS Microbiol Lett 257:293-8. 2006..cereus. In particular, the level of Nhe seems to explain most of the cytotoxic activity of B. cereus isolates and may indicate a highly diarrheic potential...
- VanA-type enterococci from humans, animals, and food: species distribution, population structure, Tn1546 typing and location, and virulence determinantsF Biavasco
Institute of Microbiology and Biomedical Sciences, Polytechnic University of Marche, Via Ranieri, Monte D Ago, 60131 Ancona, Italy
Appl Environ Microbiol 73:3307-19. 2007....
- Clinical relevance of bacteriostatic versus bactericidal mechanisms of action in the treatment of Gram-positive bacterial infectionsG A Pankey
Section of Infectious Diseases, Ochsner Clinic Foundation, New Orleans, Louisiana 70121 2483, USA
Clin Infect Dis 38:864-70. 2004..The ultimate guide to treatment of any infection must be clinical outcome...
- Role of mobile DNA in the evolution of vancomycin-resistant Enterococcus faecalisI T Paulsen
Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA
Science 299:2071-4. 2003..The apparent propensity for the incorporation of mobile elements probably contributed to the rapid acquisition and dissemination of drug resistance in the enterococci...
- Emergence of vancomycin-resistant enterococciL B Rice
VA Medical Center and Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
Emerg Infect Dis 7:183-7. 2001..Control of VRE will require better understanding of the mechanisms by which different classes of drugs promote gastrointestinal colonization...
- Characterization of fsr, a regulator controlling expression of gelatinase and serine protease in Enterococcus faecalis OG1RFX Qin
Division of Infectious Diseases, Department of Medicine, University of Texas Medical School, Houston, TX 77030, USA
J Bacteriol 183:3372-82. 2001....
- Antecedent treatment with different antibiotic agents as a risk factor for vancomycin-resistant EnterococcusYehuda Carmeli
Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
Emerg Infect Dis 8:802-7. 2002..Vancomycin was not a risk factor for isolation of VRE...
- Characterizing an outbreak of vancomycin-resistant enterococci using hidden Markov modelsE S McBryde
School of Mathematical Sciences, Queensland University of Technology, Brisbane, Queensland 4001, Australia
J R Soc Interface 4:745-54. 2007..Genotyping is commonly used to distinguish epidemic from sporadic vancomycin-resistant enterococci (VRE). We compare this to a statistical method to determine the transmission characteristics of VRE...
- Occurrence and spread of antibiotic resistances in Enterococcus faeciumIngo Klare
Robert Koch Institute, Wernigerode Branch, Burgstrasse 37, D 38855 Wernigerode, Germany
Int J Food Microbiol 88:269-90. 2003..In order to prevent the dissemination of multiple antibiotic-resistant enterococci or their transferable resistance genes, a prudent use of antibiotics is necessary in human and veterinary medicine, and in animal husbandry...
- Determinants of vancomycin resistance and mortality rates in enterococcal bacteremia. a prospective multicenter studyE N Vergis
Division of Infectious Diseases, University of Pittsburgh, Suite 3A, Falk Medical Building, 3601 Fifth Avenue, Pittsburgh, PA 15213, USA
Ann Intern Med 135:484-92. 2001..21 [CI, 0.06 to 0.80]; P = 0.02). CONCLUSIONS: Vancomycin resistance is an independent predictor of death from enterococcal bacteremia. Early, effective antimicrobial therapy is associated with a significant improvement in survival...
- Identification of a novel genomic island specific to hospital-acquired clonal complex 17 Enterococcus faecium isolatesEsther Heikens
Department of Medical Microbiology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
Appl Environ Microbiol 74:7094-7. 2008..We identified a genomic island in CC17 E. faecium tentatively encoding a metabolic pathway involved in carbohydrate transport and metabolism, which may provide a competitive advantage over the indigenous E. faecium microbiota...
- Reduction in acquisition of vancomycin-resistant enterococcus after enforcement of routine environmental cleaning measuresMary K Hayden
Dept of Medicine and Pathology, Rush University Medical Center, Chicago, IL 60612, USA
Clin Infect Dis 42:1552-60. 2006..Using vancomycin-resistant enterococci (VRE) as a marker organism, we investigated the effects of improved environmental cleaning with and without promotion of hand hygiene adherence on the spread of VRE in a medical intensive care unit...
- Determining incidence of extended spectrum beta-lactamase producing Enterobacteriaceae, vancomycin-resistant Enterococcus faecium and methicillin-resistant Staphylococcus aureus in 38 centres from 17 countries: the PEARLS study 2001-2002S K Bouchillon
Laboratories International for Microbiology Studies, 2122 Palmer Road, Schaumburg, IL 60173 3817, USA
Int J Antimicrob Agents 24:119-24. 2004..4% (294/908) and 8.7% (83/949), respectively. PEARLS provides baseline data against which prospective changes in resistant determinants and outcomes can be measured in this ongoing study...
- Outcome of a screening program for vancomycin-resistant enterococci in a hospital in VictoriaM L Grayson
Infectious Disease and Clinical Epidemiology Department, Monash Medical Center, Melbourne, Vic
Med J Aust 171:133-6. 1999..To screen for faecal colonisation with vancomycin-resistant enterococci (VRE) among potentially at-risk patients...
- Biofilm formation by enterococciJamal A Mohamed
Division of Infectious Diseases, Department of Internal Medicine, University of Texas Medical School, Houston, TX 77030, USA
J Med Microbiol 56:1581-8. 2007..This review discusses recent advances in knowledge about the biology and genetics of biofilm formation and the role of biofilms in enterococci pathogenesis...
- Daptomycin for the treatment of enterococcal bacteraemia: results from the Cubicin Outcomes Registry and Experience (CORE)John F Mohr
Cubist Pharmaceuticals, Inc, 65 Hayden Avenue, Lexington, MA 02421, USA
Int J Antimicrob Agents 33:543-8. 2009..Daptomycin may be a useful agent for treating enterococcal bacteraemia caused by E. faecium or E. faecalis. Further studies are warranted...
- Molecular characterization of gentamicin-resistant Enterococci in the United States: evidence of spread from animals to humans through foodS M Donabedian
Division of Infectious Disease, Department of Medicine, William Beaumont Hospital, Royal Oak, Detroit, Michigan 48073, USA
J Clin Microbiol 41:1109-13. 2003....
- Low serum procalcitonin level accurately predicts the absence of bacteremia in adult patients with acute feverCatherine Chirouze
Services de Maladies Infectieuses et Tropicales, University Hospital of Besancon, F 25030 Besancon Cedex, France
Clin Infect Dis 35:156-61. 2002..05). A serum PCT level of <0.4 ng/mL accurately rules out the diagnosis of bacteremia. The use of PCT assessment could help physicians limit the number of blood cultures to be processed and the number of antibiotic prescriptions...
- Global spread of vancomycin-resistant Enterococcus faecium from distinct nosocomial genetic complexRob J L Willems
University Medical Center Utrecht, Utrecht, The Netherlands
Emerg Infect Dis 11:821-8. 2005..Preventing further spread of this epidemic E. faecium subpopulation is critical, and efforts should focus on the early disclosure of ampicillin-resistant complex-17 strains...
- Influence of transferable genetic determinants on the outcome of typing methods commonly used for Enterococcus faeciumGuido Werner
Robert Koch Institute, Wernigerode Branch, 38855 Wernigerode, Germany
J Clin Microbiol 41:1499-506. 2003..Plasmid fingerprints can be included to subdifferentiate enterococcal isolates possessing identical macrorestriction and PCR typing patterns...
- Comparison of mortality associated with vancomycin-resistant and vancomycin-susceptible enterococcal bloodstream infections: a meta-analysisCarlos A DiazGranados
Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA
Clin Infect Dis 41:327-33. 2005..Whether vancomycin resistance is independently associated with mortality among patients with enterococcal bloodstream infection (BSI) is controversial. To address this issue, we performed a systematic literature review with meta-analysis...
- DNA banding pattern polymorphism in vancomycin-resistant Enterococcus faecium and criteria for defining strainsD Morrison
Laboratory of Hospital Infection, Central Public Health Laboratory, London, United Kingdom
J Clin Microbiol 37:1084-91. 1999..This study demonstrates the high degree of DNA banding pattern polymorphism found for some strains of VREM and illustrates the complexity involved in defining such strains...
- Prophylactic and therapeutic efficacy of antibodies to a capsular polysaccharide shared among vancomycin-sensitive and -resistant enterococciJ Huebner
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Infect Immun 68:4631-6. 2000..These data indicate that CP antigens from enterococci are potential targets of protective antibodies and that these antibodies may be useful for prophylaxis and treatment of enterococcal infections...
- The enterococcal surface protein, Esp, is involved in Enterococcus faecalis biofilm formationA Toledo-Arana
, , Campus de Arrosadia, 31006 Pamplona, Spain
Appl Environ Microbiol 67:4538-45. 2001..faecalis isolates, (ii) the biofilm formation capacity is restricted to the E. faecalis strains harboring esp, and (iii) Esp promotes primary attachment and biofilm formation of E. faecalis on abiotic surfaces...
- Spread of ampicillin/vancomycin-resistant Enterococcus faecium of the epidemic-virulent clonal complex-17 carrying the genes esp and hyl in German hospitalsI Klare
Robert Koch Institute, Wernigerode Branch, Burgstr 37, 38855, Wernigerode, Germany
Eur J Clin Microbiol Infect Dis 24:815-25. 2005..In conclusion, it is very important to monitor the occurrence of epidemic-virulent clonal complex-17 strains of E. faecium to prevent their spread in hospitals, especially if they are resistant to glycopeptides and linezolid...
- Multilocus sequence typing scheme for Enterococcus faeciumWieger L Homan
Research Laboratory for Infectious Diseases, National Institute of Public Health and the Environment, Bilthoven, The Netherlands
J Clin Microbiol 40:1963-71. 2002..The results show that MLST of E. faecium provides an excellent tool for isolate characterization and long-term epidemiologic analysis...
- Occurrence of co-colonization or co-infection with vancomycin-resistant enterococci and methicillin-resistant Staphylococcus aureus in a medical intensive care unitDavid K Warren
Division of Infectious Diseases, Washington University School of Medicine, St Louis, Missouri 63110, USA
Infect Control Hosp Epidemiol 25:99-104. 2004..To determine the occurrence of co-colonization or co-infection with VRE and MRSA among medical patients requiring intensive care...
- The impact of persistent gastrointestinal colonization on the transmission dynamics of vancomycin-resistant enterococciErika M C D'Agata
Department of Medicine, Division of Infectious Diseases, School of Medicine, Vanderbilt University, Nashville, Tennessee, USA
J Infect Dis 185:766-73. 2002..Decreasing the duration of colonization, limiting hospital acquisition of VRE, and improving compliance with hand hygiene in the hemodialysis unit may decrease the rapidly rising rates of VRE in the patient population...
- Daptomycin-resistant Enteroccoccus faecium in a patient with no prior exposure to daptomycinM H Fraher
J Hosp Infect 65:376-8. 2007
- Emergence of resistance to daptomycin during treatment of vancomycin-resistant Enterococcus faecalis infectionL Silvia Munoz-Price
Clin Infect Dis 41:565-6. 2005
- De novo daptomycin nonsusceptibility in a clinical isolateEmil P Lesho
J Clin Microbiol 44:673. 2006
- Population structure of Enterococcus faecium causing bacteremia in a Spanish university hospital: setting the scene for a future increase in vancomycin resistance?Teresa M Coque
Departamento de Microbiologíca, Servicio de Microbiologia, Hospital Universitario Ramon y Cajal, Carretera de Colmenar, Km 9 1, Madrid 28034, Spain
Antimicrob Agents Chemother 49:2693-700. 2005..001). These findings reflect the importance of local environmental differences in the evolution of this CC, suggesting that the emergence of vancomycin resistance among AREF strains in Spain may be a question of time...
- Linezolid for the treatment of multidrug-resistant, gram-positive infections: experience from a compassionate-use programMary C Birmingham
CPL Associates, University at Buffalo, New York, USA
Clin Infect Dis 36:159-68. 2003..1% of cases), and cutaneous reactions (4.0% of cases). Linezolid provided high rates of clinical cure and microbiological success in this complicated patient population, with very good overall tolerance...
- Linezolid: the first oxazolidinone antimicrobialRobert C Moellering
Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
Ann Intern Med 138:135-42. 2003..The drug has an acceptable profile of adverse events, but reversible myelosuppression has occurred in patients receiving high doses for more than 2 weeks...
- Association between resistance to vancomycin and death in cases of Enterococcus faecium bacteremiaJ M Garbutt
Division of General Medical Sciences, Washington University School of Medicine, St Louis, MO 63110, USA
Clin Infect Dis 30:466-72. 2000..74; 95% confidence interval, 0.5-6.12; P=.39). Vancomycin resistance does not independently increase mortality among patients with E. faecium bacteremia...
- Prevalence of resistance to ampicillin, gentamicin and vancomycin in Enterococcus faecalis and Enterococcus faecium isolates from clinical specimens and use of antimicrobials in five Nordic hospitalsG S Simonsen
University of Tromsø and University Hospital of North Norway UNN, Norway
J Antimicrob Chemother 51:323-31. 2003..faecalis isolates. This indicates a potential for further improvement of antibiotic policies, and possibly hospital infection control, to maintain the low resistance levels observed in these countries...
- Emergence of linezolid resistance in the vancomycin-resistant Enterococcus faecium multilocus sequence typing C1 epidemic lineageMaria Grazia Bonora
Dipartimento di Patologia, Sezione di Microbiologia, Universita di Verona, Strada Le Grazie 8, 37100 Verona, Italy
J Clin Microbiol 44:1153-5. 2006..Linezolid-resistant isolates carried the G2576T mutation in the 23S rRNA gene, belonged to different clones, and shared the same allelic profile, which clusters in the C1 multilocus sequence typing epidemic lineage...
- Risk factors associated with the development of infection with linezolid- and vancomycin-resistant Enterococcus faeciumManjunath P Pai
College of Pharmacy, University of New Mexico, Albuquerque, NM, USA
Clin Infect Dis 35:1269-72. 2002..These strains of E. faecium were resistant to the entire class of oxazolidinones...
- [Prevention and control of the spread of vancomycin-resistant enterococci: results of a workshop held by the German Society for Hygiene and Microbiology]R P Vonberg
Institut für Medizinische Mikrobiologie und Krankenhaushygiene, Medizinische Hochschule, Carl Neuberg Str 1, 30625, Hannover, Deutschland
Anaesthesist 56:151-7. 2007....
- Epidemiological, microbiological, clinical, and prognostic factors of bacteremia caused by high-level vancomycin-resistant Enterococcus speciesV Peset
Microbiology Department, Hospital Universitario La Fe de Valencia, Spain
Eur J Clin Microbiol Infect Dis 19:742-9. 2000..This is believed to be the first and only such outbreak described in a Spanish hospital thus far...
- Convenient selective differential broth for isolation of vancomycin-resistant enterococcus from fecal materialThomas J Novicki
Department of Laboratory Medicine, University of Washington, Seattle, Washington 98195 7110, USA
J Clin Microbiol 42:1637-40. 2004..We have thus developed an easily prepared vancomycin selective differential broth that is significantly more sensitive and specific in the detection of VRE than is direct fecal plating to BEA agar...
- Linezolid compared with teicoplanin for the treatment of suspected or proven Gram-positive infectionsMark Wilcox
Department of Microbiology, Leeds General Infirmary and University of Leeds Teaching Hospitals, Old Medical School, Leeds LS1 3EX
J Antimicrob Chemother 53:335-44. 2004..However, antibiotic discontinuation rates as a result of drug related adverse events were similar (4.7% in the linezolid group versus 3.7%). Linezolid was clinically superior to teicoplanin in the treatment of Gram-positive infections...
- Vancomycin-resistant enterococci outside the health-care setting: prevalence, sources, and public health implicationsL C McDonald
Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
Emerg Infect Dis 3:311-7. 1997..If transmission with VRE from unrecognized community sources can be identified and controlled, increased incidence of colonization and infection among hospitalized patients may be prevented...
- Measurement of ampicillin, vancomycin, linezolid and gentamicin activity against enterococcal biofilmsJonathan A T Sandoe
Department of Microbiology, The General Infirmary at Leeds, UK
J Antimicrob Chemother 57:767-70. 2006..We measured an alternative endpoint, the minimum biofilm inhibitory concentration (MBIC) and compared the results with MIC and MBC...
- Clinical and epidemiological features of Enterococcus casseliflavus/flavescens and Enterococcus gallinarum bacteremia: a report of 20 casesK C Reid
Division of Infectious Diseases, Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, MN 55905, USA
Clin Infect Dis 32:1540-6. 2001..Polymicrobial bacteremia was present in 9 patients (45%). E. gallinarum and E. casseliflavus/flavescens, although they are infrequently isolated from clinical specimens, may cause serious invasive infections...
- Nosocomial transmission of vancomycin-resistant enterococci from surfacesAmy J Ray
JAMA 287:1400-1. 2002
- Efficacy and safety of tigecycline compared with vancomycin or linezolid for treatment of serious infections with methicillin-resistant Staphylococcus aureus or vancomycin-resistant enterococci: a Phase 3, multicentre, double-blind, randomized studyI Florescu
Emergency Clinical Hospital, Bucharest, Romania
J Antimicrob Chemother 62:i17-28. 2008..Methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE) are causing serious nosocomial infections. Tigecycline was evaluated in hospitalized patients with MRSA or VRE infection...
- European survey of vancomycin-resistant enterococci in at-risk hospital wards and in vitro susceptibility testing of ramoplanin against these isolatesHerman Goossens
University Hospital Antwerp and Belgian Reference Centre of Enterococci, Edegem, Belgium
J Antimicrob Chemother 51:iii5-12. 2003..This survey suggests that in some centres in Europe, a similar situation may be encountered to that in the USA (monoclonal spread of multi-resistant VRE in at-risk wards)...
- Colonization with vancomycin-resistant enterococci in chronic hemodialysis patientsM C Roghmann
University of Maryland School of Medicine, Baltimore, USA
Am J Kidney Dis 32:254-7. 1998..This suggests that VRE transmission occurs predominantly in the inpatient setting...
- Substantially increased faecal carriage of vancomycin-resistant enterococci in a tertiary Greek hospital after a 4 year time intervalD Sofianou
Department of Microbiology, Hippokration University Hospital, Thessaloniki, Greece
J Antimicrob Chemother 54:251-4. 2004....
- Implications of colonization of vancomycin-resistant enterococci (VRE) in renal dialysis patients. Learning to live with it?H Humphreys
Department of Clinical Microbiology, Royal College of Surgeons in Ireland, Dublin, Ireland
J Hosp Infect 58:28-33. 2004....
- Dispersion of multidrug-resistant Enterococcus faecium isolates belonging to major clonal complexes in different Portuguese settingsAna R Freitas
REQUIMTE, Laboratorio de Microbiologia, Faculdade de Farmacia, Universidade do Porto, Porto, Portugal
Appl Environ Microbiol 75:4904-8. 2009..Our findings highlight the role of community-associated hosts as reservoirs of enterococci able to cause human infections...
- The analysis of hospital infection data using hidden Markov modelsBen Cooper
Department of Epidemiology, Kresge Building, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
Biostatistics 5:223-37. 2004..Compared to the standard hidden Markov model, the new approach is more parsimonious, is more biologically plausible, and allows key epidemiological parameters to be estimated...
- Evaluation of the prevalence and risk factors for colonization by vancomycin-resistant Enterococcus among patients on dialysisDulce Barbosa
Department of Nursing, Division of Nursing in Infectology, Federal University of Sao Paulo, Escola Paulista de Medicina, Sao Paulo, Brazil
Am J Kidney Dis 44:337-43. 2004..This study aims to appraise the prevalence and risk factors for VRE colonization among patients on long-term dialysis therapy, as well as the mechanisms for dissemination of vancomycin resistance...
- Vancomycin-resistant enterococci colonization in patients at seven hemodialysis centersJ I Tokars
Hospital Infections Program, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
Kidney Int 60:1511-6. 2001..We studied the prevalence of and risk factors for VRE at seven outpatient hemodialysis centers (three in Baltimore, MD, USA, and four in Richmond, VA, USA)...
- Linezolid-resistant, vancomycin-resistant Enterococcus faecium infection in patients without prior exposure to linezolidSibtain Rahim
Division of Infectious Diseases, New York University Medical Center, New York, NY, USA
Clin Infect Dis 36:E146-8. 2003..Nosocomial transmission of LRVREF is an ominous sign and underscores the importance of meticulous infection-control measures...
- Taxonomic study of Weissella confusa and description of Weissella cibaria sp. nov., detected in food and clinical samplesK Johanna Björkroth
Department of Food and Environmental Hygiene, Faculty of Veterinary Medicine, University of Helsinki, Finland
Int J Syst Evol Microbiol 52:141-8. 2002..Based on whole-cell protein electrophoresis, and ClaI and HindIII ribotyping patterns, food and clinical isolates were randomly located in the two species-specific clusters obtained...
- Molecular characterization of ampicillin-resistant Enterococcus faecium isolates from hospitalized patients in NorwayRoland Jureen
Institute of Medicine, University of Bergen, Bergen, Norway
J Clin Microbiol 41:2330-6. 2003..Rectal and clinical isolates were generally indistinguishable, and differences in clonal distribution and allele polymorphism were found mainly between ampicillin-resistant and -susceptible isolates...
- Control of nosocomial acquisition of vancomycin-resistant Enterococcus through active surveillance of hemodialysis patientsR Neal Axon
Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
Infect Control Hosp Epidemiol 25:436-8. 2004..05). To assess the effectiveness of active surveillance, patients undergoing active surveillance should be analyzed separately from other patients...
- A prospective incidence study of nosocomial infections in a neonatal care unitMireya Urrea
Quality Service Infection Hospital Program, Hospital Sant Joan de Deu de Barcelona, Barcelona, Spain
Am J Infect Control 31:505-7. 2003..However, nosocomial infections (NI) still represent an important cause of morbidity and mortality in this population...
- Hospital-acquired vancomycin-resistant enterococci: now appearing in Kuala Lumpur HospitalA W Zubaidah
Department of Pathology, Kuala Lumpur Hospital
Med J Malaysia 61:487-9. 2006..The microbiology laboratory plays an important role in the identification and detection of VRE...
- Nosocomial spread of Enterococcus faecium resistant to vancomycin and linezolid in a tertiary care medical centerThomas E Dobbs
Department of Medicine, University of Alabama at Birmingham, 619 South 19th St, 35249, USA
J Clin Microbiol 44:3368-70. 2006..Epidemiologic investigation and pulsed-field gel electrophoresis patterns indicated a clonal outbreak related to nosocomial spread...
- Bacillus cereus central line infection in an immunocompetent child with hemophiliaPoyyapakkam R Srivaths
Tulane University School of Medicine, Huey P Long Medical Center, Department of Pediatrics, New Orleans, Louisiana, USA
J Pediatr Hematol Oncol 26:194-6. 2004..The authors report a case of Bacillus cereus infection of a central line in an immunocompetent patient with hemophilia, which required line removal for complete cure...
- Costs and savings associated with infection control measures that reduced transmission of vancomycin-resistant enterococci in an endemic settingM A Montecalvo
Division of Infectious Diseases, New York Medical College, Valhalla 10595, USA
Infect Control Hosp Epidemiol 22:437-42. 2001....
- Effects of daptomycin in combination with other antimicrobial agents: a review of in vitro and animal model studiesJudith N Steenbergen
Cubist Pharmaceuticals Inc, Lexington, MA 02421, USA
J Antimicrob Chemother 64:1130-8. 2009..e. osteomyelitis and implant infections, where rifampicin combinations with daptomycin increased efficacy and reduced the incidence of rifampicin resistance...
- Increasing rates of vancomycin resistance among Enterococcus faecium isolated from German hospitals between 2004 and 2006 are due to wide clonal dissemination of vancomycin-resistant enterococci and horizontal spread of vanA clustersGuido Werner
Robert Koch Institute, Wernigerode Branch, D 38855 Wernigerode, Germany
Int J Med Microbiol 298:515-27. 2008..In conclusion, the increase in the rates of VREF among German hospital patients within the last 2 years might be rather complex and due to different molecular events and scenarios...
- Vancomycin-resistant enterococci among chronic hemodialysis patients: a prospective study of acquisitionE M D'Agata
Department of Medicine, Division of Infectious Diseases, Vanderbilt University School of Medicine, Nashville, TN 37232 2605, USA
Clin Infect Dis 32:23-9. 2001..Hospital acquisition of VRE contributes substantially to the increasing prevalence of VRE in the chronic hemodialysis patient population...
- Vancomycin-resistant enterococcal colonization and infection in liver transplant candidates and recipients: a prospective surveillance studyShelly A McNeil
Division of Infectious Diseases, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, Michigan, USA
Clin Infect Dis 42:195-203. 2006..We performed a prospective study among patients awaiting transplantation to assess rates, risk factors, and outcomes associated with VRE colonization before and after transplantation...
- Modulation of virulence within a pathogenicity island in vancomycin-resistant Enterococcus faecalisNathan Shankar
of Pharmaceutical Sciences, University of Oklahoma Health Sciences Center, PO Box 26901, Oklahoma City, Oklahoma 73190, USA
Nature 417:746-50. 2002....
- 16S ribosomal DNA sequence-based analysis of clinically significant gram-positive anaerobic cocciYuli Song
Research Service Clinical Microbiology Laboratory, VA Medical Center West Los Angeles, California 90073, USA
J Clin Microbiol 41:1363-9. 2003..This finding is in contrast to the phenotypic identification results, by which only 56% of isolates were correctly identified to species level...
- Bacteremia in febrile Malawian children: clinical and microbiologic featuresA L Walsh
Wellcome Trust Research Laboratories, University of Malawi, Blantyre
Pediatr Infect Dis J 19:312-8. 2000..There are no published data for the incidence or etiology of childhood bacteremia in Malawi. We describe the clinical and microbiologic features of children admitted to hospital from whom blood cultures yielded bacterial pathogens...
- Influence of origin of isolates, especially endocarditis isolates, and various genes on biofilm formation by Enterococcus faecalisJamal A Mohamed
Division of Infectious Diseases, Department of Internal Medicine, University of Texas Medical School, Houston, Texas 77030, USA
Infect Immun 72:3658-63. 2004..faecalis regulator) [corrected] resulted in fewer attached bacteria, as determined using phase-contrast microscopy, and less biofilm (P < 0.0001)...
- Vancomycin-resistant enterococci in intensive-care hospital settings: transmission dynamics, persistence, and the impact of infection control programsD J Austin
Wellcome Trust Centre for the Epidemiology of Infectious Disease, University of Oxford, South Parks Road, Oxford OX1 3PS, United Kingdom
Proc Natl Acad Sci U S A 96:6908-13. 1999..Our analyses suggest that compliance for hand washing significantly in excess of reported levels, or the cohorting of nursing staff, are needed to prevent nosocomial transmission of VRE in endemic settings...
- Lipoprotein biogenesis in Gram-positive bacteria: knowing when to hold 'em, knowing when to fold 'emMatthew I Hutchings
School of Biological Sciences, University of East Anglia, Norwich, NR4 7TJ, UK
Trends Microbiol 17:13-21. 2009..Here, we review recent discoveries concerning the export and processing of these proteins, their role in virulence in Gram-positive bacteria and their potential as vaccine candidates or targets for new antimicrobials...
- Propionibacterium acnes associated with inflammation in radical prostatectomy specimens: a possible link to cancer evolution?Ronald J Cohen
Uropath Pty Ltd, Perth, Western Australia
J Urol 173:1969-74. 2005..The etiology of prostatic inflammation is unknown. However, the involvement of a carcinogenic infectious agent has been suggested...
- Role of Enterococcus faecalis surface protein Esp in the pathogenesis of ascending urinary tract infectionN Shankar
Department of Pharmaceutical Sciences, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73190, USA
Infect Immun 69:4366-72. 2001..We conclude that, while Esp does not influence histopathological changes associated with acute urinary tract infections, it contributes to colonization and persistence of E. faecalis at this site...
- Multilocus sequence typing scheme for bacteria of the Bacillus cereus groupErlendur Helgason
Biotechnology Centre of Oslo and School of Pharmacy, Oslo, Norway
Appl Environ Microbiol 70:191-201. 2004..anthracis isolates analyzed had the same ST. The MLST scheme which we developed has a high level of resolution and should be an excellent tool for studying the population structure and epidemiology of the B. cereus group...
- Antibiotic-resistant enterococci: the mechanisms and dynamics of drug introduction and resistanceBrett D Shepard
Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, 975 NE 10th St, BRC 356, Oklahoma City, Oklahoma, USA
Microbes Infect 4:215-24. 2002..This review summarizes current concepts regarding the mechanisms of resistance, as well as the emergence, proliferation, and epidemiology of resistant enterococci...
- Daptomycin: another novel agent for treating infections due to drug-resistant gram-positive pathogensChristopher F Carpenter
Division of Infectious Diseases, William Beaumont Hospital, Royal Oak, Michigan, USA
Clin Infect Dis 38:994-1000. 2004..The rapid bactericidal activity, low potential for resistance, and promising safety profile associated with this agent will make it a useful addition to our growing armamentarium of antibiotics active against gram-positive pathogens...
- Function of the drosophila pattern-recognition receptor PGRP-SD in the detection of Gram-positive bacteriaVincent Bischoff
Institut de Biologie Moleculaire et Cellulaire, CNRS UPR 9022, 15 rue Rene Descartes, Universite Louis Pasteur, 67084 Strasbourg Cedex, France
Nat Immunol 5:1175-80. 2004..These data indicate that PGRP-SD can function as a receptor for Gram-positive bacteria and shows partial redundancy with the PGRP-SA-GNBP1 complex...
- Characterization of a vancomycin-resistant Enterococcus faecalis (VREF) isolate from a dog with mastitis: further evidence of a clonal lineage of VREF in New ZealandJanet M Manson
Department of Microbiology, Otago School of Medical Sciences, University of Otago, Dunedin, New Zealand
J Clin Microbiol 41:3331-3. 2003..Comparison of this isolate with VREF from poultry and human sources in New Zealand demonstrated identical SmaI macrorestriction patterns and Tn1546-like elements. This is further evidence of a clonal lineage of VREF in New Zealand...
- Emergence of daptomycin resistance in Enterococcus faecium during daptomycin therapyJames S Lewis
Antimicrob Agents Chemother 49:1664-5. 2005
- Contribution of the collagen adhesin Acm to pathogenesis of Enterococcus faecium in experimental endocarditisSreedhar R Nallapareddy
Department of Internal Medicine, Division of Infectious Diseases, Center for the Study of Emerging and Re Emerging Pathogens, University of Texas Medical School, Houston, Texas 77030, USA
Infect Immun 76:4120-8. 2008..faecium collagen adherence by affinity-purified anti-Acm antibodies from E. faecium endocarditis patient sera, suggesting that Acm may be a potential immunotarget for strategies to control this emerging pathogen...
- Microbiological features of vancomycin in the 21st century: minimum inhibitory concentration creep, bactericidal/static activity, and applied breakpoints to predict clinical outcomes or detect resistant strainsRonald N Jones
JMI Laboratories, North Liberty, IA 52317, USA
Clin Infect Dis 42:S13-24. 2006....
- Molecular identification of Leuconostoc mesenteroides as a cause of brain abscess in an immunocompromised patientAlessio Albanese
Department of Neurosurgery, Catholic University of the Sacred Heart, Rome, Italy
J Clin Microbiol 44:3044-5. 2006..Using molecular methods, we identified Leuconostoc mesenteroides as the cause of a brain abscess which was successfully treated by surgery and antimicrobial treatment. This is the first report of brain abscess caused by this species...
- Identification of glycopeptide-resistant enterococci by VITEK 2 system and conventional and real-time polymerase chain reactionAlexandra Eisner
Institute of Hygiene, Medical University of Graz A 8010, Austria
Diagn Microbiol Infect Dis 53:17-21. 2005..High specificity and rapidity make the real-time PCR assays superior tools for identification of GRE in clinical samples; however, they do not have the ability to detect vanC...
- Multiple-locus variable-number tandem repeat analysis, a novel typing scheme to study the genetic relatedness and epidemiology of Enterococcus faecium isolatesJanetta Top
Eijkman Winkler Institute for Microbiology, Infectious Diseases and Inflammation, University Medical Center Utrecht, Utrecht, The Netherlands
J Clin Microbiol 42:4503-11. 2004..Furthermore, it has the abilities of MLST to recognize genetically related and potential epidemic isolates. Submission of MLVA profiles is possible via a Web-based database for international comparison...
- Reply to Nannini and to a previous letter by HurleyCarlos A DiazGranados
Clin Infect Dis 42:1204-5. 2006
- Increasing prevalence of vancomycin-resistant enterococci, and cefoxitin-, imipenem- and fluoroquinolone-resistant gram-negative bacilli: a KONSAR study in 2002Kyungwon Lee
Department of Laboratory Medicine, Research Institute of Bacterial Resistance, Yonsei University College of Medicine, 134 Shinchon dong, Seodaemun gu, Seoul 120 752, Korea
Yonsei Med J 45:598-608. 2004..aeruginosa and Acinetobacter spp. increased gradually, and imipenem- resistant E. coli and K. pneumoniae appeared for the first time. Continued surveillance is required to prevent further spread of these serious resistances...
- Endocarditis due to vancomycin-resistant enterococci: case report and review of the literatureMichael P Stevens
Virginia Commonwealth University Medical Center, Richmond, VA 23298 0019, USA
Clin Infect Dis 41:1134-42. 2005..Endocarditis due to vancomycin-resistant enterococci (VRE) is rare, and the literature consists almost exclusively of reports of single cases...
- Elucidating beta-lactamase functional mechanisms via evolutionary conservationDennis R Livesay; Fiscal Year: 2013..As such, we propose a series of additional studies along these lines to expand our understanding of BL structure and function, potentially paving the way to new therapeutic opportunities. ..
- Isothermal Titration CalorimeterRobert S Hodges; Fiscal Year: 2013..S.) The success of many of these research projects depends on having state-of-the-art equipment to determine binding interactions and structure-function relationships. ..
- Antibacterial Resistance Leadership Group (ARLG)Vance G Fowler; Fiscal Year: 2013..abstract_text> ..
- GENETIC AND CHEMICAL APPROACHES TO NOVEL LIPID II BINDING PEPTIDE ANTIBIOTICSXihou Yin; Fiscal Year: 2010..Understanding the molecular basis of enduracidin resistance in the producing organism will help predict how new antibiotics may be affected by existing resistance mechanisms and provide insight into ways that resistance may emerge. ..
- GLYCOPEPTIDE ANTIBOTIC MECHANISM AND RESISTANCETAD KOCH; Fiscal Year: 2001..The research will provide a further understanding of how secondary metabolites of microorganisms are designed to function as antibiotics without being too toxic to the microorganism which creates them. ..
- S. mutans: Its mutacin AntibioticFengxia Qi; Fiscal Year: 2007..mutans. This knowledge will help design effective control measures to curb the growth and virulence of S. mutans in the dental _laque. ..
- Catheter Dwell Time and Risk of Bloodstream Infections in Hospitalized NeonatesAaron M Milstone; Fiscal Year: 2011..This project will help to develop evidence-based strategies to prevent bloodstream infections among vulnerable infants hospitalized in the neonatal intensive care unit. ..
- HUMAN RETROVIRUS-5 AND ARTHRITISRobin Patel; Fiscal Year: 2002..Identification of a specific infectious agent associated with these arthritides would potentially allo for the development of preventive strategies such as vaccination and novel therapeutic approaches. ..
- Detection of Biofilm Bacteria using GloBacRobin Patel; Fiscal Year: 2008..The goal of the proposed studies is to develop a rapid test for detection of bacteria on artificial joints that can be used in the operating room to diagnose infected artificial joints. [unreadable] [unreadable] [unreadable]..
- Enhancement of antimicrobics by electrical currentRobin Patel; Fiscal Year: 2007..This novel but simple resistance reversing strategy may generalize to a wide variety of antimicrobics and microorganisms and a wide variety of biofilm-associated human infections. [unreadable] [unreadable] [unreadable] [unreadable]..
- Transmission Dynamics of Antimocrobial-resistant bacteria in dialysis unitsERIKA D AGATA; Fiscal Year: 2007..Limiting ARB spread will ultimately reduce infections caused by ARB and improve CHD patient outcomes. [unreadable] [unreadable] [unreadable]..
- REGULATION OF NEUTROPHIL OXIDATIVE RESPONSES IN TRAUMAJoseph Solomkin; Fiscal Year: 2004..Together, these studies will define potential points for therapeutic intervention and provide important insight into regulation of the acute inflammatory response. ..
- Appropriate Pneumococcal Vaccination in Infants in FijiFiona Russell; Fiscal Year: 2007..The results of this study will form the basis of an effectiveness evaluation following the pilot introduction of pneumococcal immunization into Fiji in 3-5 years time. [unreadable] [unreadable]..
- Periodontitis, Atherosclerosis and the Host ResponseEvanthia Lalla; Fiscal Year: 2007..We propose to employ this model to dissect the factors accelerating vascular inflammation and atherosclerosis in periodontitis. ..
- BASIC MECHANISMS IN LUNG DISEASEJanet Yother; Fiscal Year: 2007..Based on our program's strong record of productivity and its importance in these endeavors, we seek to continue our role in training young investigators for productive careers in pulmonary research. ..
- HIV ASSOCIATED NEPHROPATHY IN DRUG ADDICTSPravin Singhal; Fiscal Year: 2007..3. Drugs modulation of the renin-angiotensin system contributes to the progression of renal lesions in mice with HIVAN. [unreadable] [unreadable] [unreadable]..
- Pattern Recognition Molecule Mindin As AdjuvantYou Wen He; Fiscal Year: 2007..Third, Mindin fused DNA plasmids will be examined for their efficacy in protecting influenza virus infection. [unreadable] [unreadable]..
- Role of Inter-alpha Inhibitors in Anthrax IntoxicationSteven Opal; Fiscal Year: 2007..Our research is focused on the development of a new and safe treatment based on the ability of inter-alpha proteins to prevent the fatal consequences of anthrax infection. [unreadable] [unreadable] [unreadable] [unreadable]..
- Enterococcus faecium virulence: A molecular and therapeutic approachCesar Arias; Fiscal Year: 2008..A translational approach using the mentor's laboratory established animal models (mouse peritonitis and rat infective endocarditis) will be utilized to explore therapeutic approaches. [unreadable] [unreadable] [unreadable]..
- Incidence & Outcomes of SSI After Breast Cancer SurgeryMargaret Olsen; Fiscal Year: 2008....
- Artificial Cornea Based on Photolithographically Patterned, Biomimetic HydrogelsChristopher N Ta; Fiscal Year: 2010..3. Determine the skirt design for optimal stromal tissue integration by evaluating in vitro and in vivo stromal wound healing within photolithographically patterned, microperforated hydrogel arrays. ..
- Type II secretion system of P. aeruginosa in acute lung infectionReuben Ramphal; Fiscal Year: 2010..We wish to examine which of the many known toxins are involved in death and to explore new methods to block secretion of the toxins that may eventually be useful for therapy. ..
- Genome Sequencing of Toxoplasma gondiiIan Paulsen; Fiscal Year: 2002..gondii research community is solidly behind this effort, and the history of this group (in supporting and successfully exploiting the T. gondii EST project, for example) bodes well for successful utilization of the genomic sequence...
- Mechanisms of polysacchairde synthesis by S. pneumoniaeJANET L YOTHER; Fiscal Year: 2010..The relevance of these properties to the pathogenesis of S. pneumoniae will also be assessed, allowing us to better understand an essential virulence factor of this and many other bacteria. ..
- Microbial Correlates of Bacterial Vaginosis Treatment Failure and Recurrence in HMichael Ferris; Fiscal Year: 2008..Significance: The results should lead to more effective methods of diagnosing and treating BV, and preventing the serious sequelae associated with this common syndrome. ..
- Stopping URIs and FLU in the Family: the Stuffy TrialElaine Larson; Fiscal Year: 2008....
- Susceptibility Testing, Treatment Choices, and Outcomes of MDR-GNB InfectionsLisa Maragakis; Fiscal Year: 2009..This research is designed to better understand how providers use information from various microbiology laboratory testing methods to choose treatments and to identify strategies that lead to the best patient outcomes. ..
- Microfluidic system for point of care diagnosis of GBSMichel Bergeron; Fiscal Year: 2008..Moreover, this technology could also be applicable to the detection of other infectious disease agents including biological warfare agents. ..
- PSEUDOMONAS AERUGINOSA FLAGELLAR BIOGENESIS PATHWAYReuben Ramphal; Fiscal Year: 2007..abstract_text> ..
- Antibacterial peptidoglycan recognition proteinsRoman Dziarski; Fiscal Year: 2007..abstract_text> ..
- Extracellular Matrix Protein in Innate ImmunityYou Wen He; Fiscal Year: 2007..Results from this proposal will provide novel insights on the mechanisms of the innate immune response and may have implication for clinical treatment of septic shock and other microbe caused diseases. [unreadable] [unreadable]..
- CUTANEOUS ONCOLOGYMadeleine Duvic; Fiscal Year: 2004..Young physicians and students who receive advanced training in the proper detection, prevention, and treatment of skin cancers will be a resource and may improve outcomes for patients of the future. ..
- LETHAL OROESOPHAGEAL CANDIDIASIS: IMMUNOTHERAPYEdward Balish; Fiscal Year: 2004..Restoration and enhancement of immune function may be critical for the effectiveness of anti-Candida vaccines that are now under development. ..
- Staff Hand Hygiene and Nosocomial Infections in NeonatesElaine Larson; Fiscal Year: 2003....
- Gordon Research Conference on Staphylococcal DiseasesBRIGITTE BERGER BACHI; Fiscal Year: 2003..S. This will afford a unique and rich opportunity for fellowship and scientific exchange between young and established investigators in the field. ..
- XYLITOL FOR ACUTE OTITIS MEDIA PROPHYLAXISLouis Vernacchio; Fiscal Year: 2003..A preliminary estimate of the effect size of xylitol treatment from the pilot RCT will suggest whether the effect if sufficiently large to warrant a large formal RCT to be proposed. ..
- OCULAR MELANOMAPaul Finger; Fiscal Year: 2003..Standardized clinical and data collection procedures will be employed, and standardized forms will be used in all centers. Central training and certification of all study staff will be required. ..
- HOME HYGIENE INTERVENTIONElaine Larson; Fiscal Year: 2002..Logistic regression, Liang-Zeger regression, and Chi Square analyses will be used to test differences in rates of transmission of symptoms and changes in quantity, types and resistance patterns of microbial flora of the hands. ..
- Periodontal microbiota, serum Antibody response & T1DMEvanthia Lalla; Fiscal Year: 2002..Theses studies will markedly enhance our understanding of the oral microbiology and immunology in type 1 diabetes. ..
- 6th ASM Conference on Streptococcal GeneticsJanet Yother; Fiscal Year: 2002..The present conference will follow that trend, as we focus on the work of both established and young scientists. ..
- Proline uptake in staphylococcus aureus pathogenesisWILLIAM SCHWAN; Fiscal Year: 2002..The results of this study will help us understand the role of proline transport in S. aureus infections. ..
- FLAGELLIN GLYCOSYLATION AND VIRULENCE OF P. AEROGINOSAReuben Ramphal; Fiscal Year: 2005..The existence of a central gene product involved in these could prove to be of great significance in controlling virulence. ..
- FimX in Regulation of Type IV Pili ExpressionThomas Murray; Fiscal Year: 2005..These studies will determine whether c-diGMP is a second messenger regulating twitching motility in PA. We also will characterize the first ABC transporters identified in PA involved in controlling TFP expression. ..
- Chemokines and microglia in Alzheimer's diseaseJoseph El Khoury; Fiscal Year: 2005....
- Enterococcus cytolysin: Regulation and structureMichael Gilmore; Fiscal Year: 2007..abstract_text> ..
- Prevention of Healthcare-Associated Drug-Resistant GNRLisa Maragakis; Fiscal Year: 2006..Maragakis with the skills she needs to develop into an independent clinical investigator in epidemiologic research for the prevention of healthcare-associated infections. ..
- ORPHAN NUCLEAR RORgammat IN THYMOCYTE DIFFERENTIATIONYou Wen He; Fiscal Year: 2006..In addition, results from this application will also provide insights for the role of ROR-gamma-t in tumorigenesis. ..
- Interdisciplinary Research:Antimicrobial Resistance(RMI)Elaine Larson; Fiscal Year: 2006..In the final year, plans for a sustainable Consortium on antimicrobial resistance will be formalized. [unreadable] [unreadable]..
- Efficient Mechanism of Gene Transfer in B. fragilisDavid Hecht; Fiscal Year: 2006..abstract_text> ..
- Resistant E.coli in Humans and PoultryJames Johnson; Fiscal Year: 2005..Does the research address a current and compelling problem of antimicrobial resistance that is of high public health importance and for which research is needed? [yes]. ..
- Impact of Hand Hygiene Guideline on Infections and CostsElaine Larson; Fiscal Year: 2005..abstract_text> ..
- ROLE OF ADHERENCE IN KERATITISMichael Gilmore; Fiscal Year: 2001..abstract_text> ..
- OmpR and acid regulation of Escherichia coli fim genesWILLIAM SCHWAN; Fiscal Year: 2007..unreadable] [unreadable] [unreadable] [unreadable]..
- Legionella pneumophila developmental cycle & virulencePAUL STOKES HOFFMAN; Fiscal Year: 2011..These studies should also provide insights relevant to other opportunistic environmental pathogens including oxiella, Burkholderia and species of Mycobacterium. ..
- ROLE OF ENDOTHELIN IN PERINATAL PULMONARY VASOREGULATIONDAVID IVY; Fiscal Year: 2002..Research presentations along with graduate level courses in molecular biology, and the clinical ambiance of the Univ of CO SOM in the area of pulmonary hypertension enhance career development. ..
- Pathogen-specific drug targets for weaponized bacteriaVincent Fischetti; Fiscal Year: 2007..In total, these efforts target central virulence factors in critical biowarfare pathogens. ..