gram negative bacterial infections

Summary

Summary: Infections caused by bacteria that show up as pink (negative) when treated by the gram-staining method.

Top Publications

  1. ncbi Nosocomial bloodstream infections in US hospitals: analysis of 24,179 cases from a prospective nationwide surveillance study
    Hilmar Wisplinghoff
    Department of Internal Medicine, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, USA
    Clin Infect Dis 39:309-17. 2004
  2. pmc Bloodstream infections caused by antibiotic-resistant gram-negative bacilli: risk factors for mortality and impact of inappropriate initial antimicrobial therapy on outcome
    Cheol In Kang
    Department of Internal Medicine, Seoul National University College of Medicine, 28 Yongon dong Chongno gu, Seoul 110 744, Republic of Korea
    Antimicrob Agents Chemother 49:760-6. 2005
  3. ncbi Natural history of colonization with vancomycin-resistant enterococci, methicillin-resistant Staphylococcus aureus, and resistant gram-negative bacilli among long-term-care facility residents
    Glenn A Pacio
    Division of Infectious Diseases, New York Medical College, Valhalla 10595, USA
    Infect Control Hosp Epidemiol 24:246-50. 2003
  4. ncbi Clinical characteristics and prognostic factors of patients with Stenotrophomonas maltophilia bacteremia
    Chung Hsu Lai
    Section of Infectious Diseases, Department of Medicine, Taipei Veterans General Hospital and National Yang Ming University, Taipei, Taiwan, ROC
    J Microbiol Immunol Infect 37:350-8. 2004
  5. ncbi Molecular and phenotypic features for identification of the opportunistic pathogens Ochrobactrum spp
    Corinne Teyssier
    Laboratoire de Bacteriologie, Faculte de Pharmacie, 15, Avenue Charles Flahault, 34093 Montpellier Cedex 5, France
    J Med Microbiol 54:945-53. 2005
  6. ncbi Development of a miniaturised microarray-based assay for the rapid identification of antimicrobial resistance genes in Gram-negative bacteria
    Miranda Batchelor
    Department of Food and Environmental Safety, Veterinary Laboratories Agency, Addlestone, Surrey, UK
    Int J Antimicrob Agents 31:440-51. 2008
  7. ncbi Colistin treatment in patients with ICU-acquired infections caused by multiresistant Gram-negative bacteria: the renaissance of an old antibiotic
    A S Michalopoulos
    Intensive Care Unit, Henry Dunant Hospital, Athens, Greece
    Clin Microbiol Infect 11:115-21. 2005
  8. ncbi Type III secretion machines: bacterial devices for protein delivery into host cells
    J E Galan
    Section of Microbial Pathogenesis, Boyer Center for Molecular Medicine, Yale School of Medicine, New Haven, CT 06536, USA
    Science 284:1322-8. 1999
  9. ncbi Bacteremia caused by Achromobacter and Alcaligenes species in 46 patients with cancer (1989-2003)
    Gabriel Aisenberg
    Department of Infectious Diseases, Infection Control, and Employee Health, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Cancer 101:2134-40. 2004
  10. pmc Genotypic and phenotypic relationships between clinical and environmental isolates of Stenotrophomonas maltophilia
    G Berg
    Department of Microbiology, University of Rostock, D 18055 Rostock, Germany
    J Clin Microbiol 37:3594-600. 1999

Detail Information

Publications245 found, 100 shown here

  1. ncbi Nosocomial bloodstream infections in US hospitals: analysis of 24,179 cases from a prospective nationwide surveillance study
    Hilmar Wisplinghoff
    Department of Internal Medicine, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, USA
    Clin Infect Dis 39:309-17. 2004
    ..Nosocomial bloodstream infections (BSIs) are important causes of morbidity and mortality in the United States...
  2. pmc Bloodstream infections caused by antibiotic-resistant gram-negative bacilli: risk factors for mortality and impact of inappropriate initial antimicrobial therapy on outcome
    Cheol In Kang
    Department of Internal Medicine, Seoul National University College of Medicine, 28 Yongon dong Chongno gu, Seoul 110 744, Republic of Korea
    Antimicrob Agents Chemother 49:760-6. 2005
    ..72; P = 0.030). Our data suggest that inappropriate initial antimicrobial therapy is associated with adverse outcome in antibiotic-resistant gram-negative bacteremia, particularly in patients with a high-risk source of bacteremia...
  3. ncbi Natural history of colonization with vancomycin-resistant enterococci, methicillin-resistant Staphylococcus aureus, and resistant gram-negative bacilli among long-term-care facility residents
    Glenn A Pacio
    Division of Infectious Diseases, New York Medical College, Valhalla 10595, USA
    Infect Control Hosp Epidemiol 24:246-50. 2003
    ..To determine the natural history of colonization with vancomycin-resistant enterococci (VRE), methicillin-resistant Staphylococcus aureus (MRSA), and resistant gram-negative bacilli among long-term-care facility (LTCF) residents...
  4. ncbi Clinical characteristics and prognostic factors of patients with Stenotrophomonas maltophilia bacteremia
    Chung Hsu Lai
    Section of Infectious Diseases, Department of Medicine, Taipei Veterans General Hospital and National Yang Ming University, Taipei, Taiwan, ROC
    J Microbiol Immunol Infect 37:350-8. 2004
    ..The source of bacteremia and condition of patients at presentation were the major factors influencing prognosis...
  5. ncbi Molecular and phenotypic features for identification of the opportunistic pathogens Ochrobactrum spp
    Corinne Teyssier
    Laboratoire de Bacteriologie, Faculte de Pharmacie, 15, Avenue Charles Flahault, 34093 Montpellier Cedex 5, France
    J Med Microbiol 54:945-53. 2005
    ..anthropi and O. intermedium to the species level. However, definitive identification depends on genotyping methods...
  6. ncbi Development of a miniaturised microarray-based assay for the rapid identification of antimicrobial resistance genes in Gram-negative bacteria
    Miranda Batchelor
    Department of Food and Environmental Safety, Veterinary Laboratories Agency, Addlestone, Surrey, UK
    Int J Antimicrob Agents 31:440-51. 2008
    ....
  7. ncbi Colistin treatment in patients with ICU-acquired infections caused by multiresistant Gram-negative bacteria: the renaissance of an old antibiotic
    A S Michalopoulos
    Intensive Care Unit, Henry Dunant Hospital, Athens, Greece
    Clin Microbiol Infect 11:115-21. 2005
    ..9) and acute renal failure (OR, 8.2; 95% CI 2.9-23.8) were independent predictors of mortality. Colistin should be considered as a treatment option in critically ill patients with infection caused by multiresistant Gram-negative bacilli...
  8. ncbi Type III secretion machines: bacterial devices for protein delivery into host cells
    J E Galan
    Section of Microbial Pathogenesis, Boyer Center for Molecular Medicine, Yale School of Medicine, New Haven, CT 06536, USA
    Science 284:1322-8. 1999
    ..Understanding the biology of these devices may allow the development of novel prevention and therapeutic approaches for several infectious diseases...
  9. ncbi Bacteremia caused by Achromobacter and Alcaligenes species in 46 patients with cancer (1989-2003)
    Gabriel Aisenberg
    Department of Infectious Diseases, Infection Control, and Employee Health, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Cancer 101:2134-40. 2004
    ..The authors sought to determine the incidence and characteristics of bloodstream infections caused by these organisms in patients with underlying malignancies...
  10. pmc Genotypic and phenotypic relationships between clinical and environmental isolates of Stenotrophomonas maltophilia
    G Berg
    Department of Microbiology, University of Rostock, D 18055 Rostock, Germany
    J Clin Microbiol 37:3594-600. 1999
    ..Computer-assisted cluster analysis of the phenotypic and genotypic features did not reveal any clustering patterns for either clinical or environmental isolates...
  11. ncbi The rising influx of multidrug-resistant gram-negative bacilli into a tertiary care hospital
    Aurora E Pop-Vicas
    Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Clin Infect Dis 40:1792-8. 2005
    ....
  12. pmc Arcobacter species in humans
    Olivier Vandenberg
    Department of Microbiology, Saint Pierre University Hospital, B 1000 Brussels, Belgium
    Emerg Infect Dis 10:1863-7. 2004
    ..Our observations suggest that A. butzleri displays microbiologic and clinical features similar to those of Campylobacter jejuni; however, A. butzleri is more frequently associated with a persistent, watery diarrhea...
  13. ncbi New beta-lactamases in gram-negative bacteria: diversity and impact on the selection of antimicrobial therapy
    K Bush
    The R W Johnson Pharmaceutical Research Institute, Raritan, NJ, 08869, USA
    Clin Infect Dis 32:1085-9. 2001
    ..Appreciation of these factors may help the physician make a more informed decision when choosing therapy to try to avoid selection of even more pathogenic strains...
  14. ncbi Comparative activity of new quinolones against 326 clinical isolates of Stenotrophomonas maltophilia
    K Weiss
    Hopital Maisonneuve Rosemont, University of Montreal, Montreal, Quebec, Canada H1T 2M4
    J Antimicrob Chemother 45:363-5. 2000
    ..maltophilia, notably lower respiratory tract infections...
  15. ncbi Nosocomial bacteremia caused by antibiotic-resistant gram-negative bacteria in critically ill patients: clinical outcome and length of hospitalization
    Stijn Blot
    Department of Intensive Care, Ghent University Hospital, B 9000 Ghent, Belgium
    Clin Infect Dis 34:1600-6. 2002
    ..032) were independently associated with in-hospital mortality (P<.05). Antibiotic resistance in nosocomial bacteremia caused by gram-negative bacteria does not adversely affect the outcome for critically ill patients...
  16. pmc The genus Aeromonas: biochemical characteristics, atypical reactions, and phenotypic identification schemes
    Sharon L Abbott
    Microbial Diseases Laboratory, Division of Communicable Disease Control, California Department of Health Services, Richmond, California 94804, USA
    J Clin Microbiol 41:2348-57. 2003
    ..In addition, several new tests were identified that help to separate members of the A. caviae complex (A. caviae, A. media, and A. eucreonophila)...
  17. ncbi Pulsed-field gel electrophoriesis analyis of Aeromonas salmonicida ssp. salmonicida
    J A Garcia
    Department of Veterinary Microbiology, The Royal Veterinary and Agricultural University, Frederiksberg, Denmark
    FEMS Microbiol Lett 190:163-6. 2000
    ..Our results suggest a clonal distribution of this subspecies, with a predominant clone being responsible for most of the outbreaks worldwide...
  18. ncbi Low serum procalcitonin level accurately predicts the absence of bacteremia in adult patients with acute fever
    Catherine Chirouze
    Services de Maladies Infectieuses et Tropicales, University Hospital of Besancon, F 25030 Besancon Cedex, France
    Clin Infect Dis 35:156-61. 2002
    ..05). A serum PCT level of <0.4 ng/mL accurately rules out the diagnosis of bacteremia. The use of PCT assessment could help physicians limit the number of blood cultures to be processed and the number of antibiotic prescriptions...
  19. ncbi Clinical and microbiological outcomes of serious infections with multidrug-resistant gram-negative organisms treated with tigecycline
    Kara B Anthony
    Division of Infectious Diseases, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Clin Infect Dis 46:567-70. 2008
    ..Observed evolution of resistance during therapy raises concern about routine use of tigecycline in treatment of such infections when other therapies are available...
  20. ncbi Detection of Flavobacterium psychrophilum from fish tissue and water samples by PCR amplification
    T Wiklund
    Fish Disease Laboratory, Danish Institute for Fisheries Research, The Royal Veterinary and Agricultural University, Frederiksberg C, Denmark
    J Appl Microbiol 88:299-307. 2000
    ..The method presented here has the potential to detect low levels of Fl. psychrophilum in fish tissue and in water samples, and the technique can be a useful tool for understanding the epidemiology of Fl. psychrophilum...
  21. pmc Contemporary assessment of antimicrobial susceptibility testing methods for polymyxin B and colistin: review of available interpretative criteria and quality control guidelines
    A C Gales
    Department of Pathology, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
    J Clin Microbiol 39:183-90. 2001
    ..Clinical laboratories should exclusively use MIC methods to assist the therapeutic application of colistin or polymyxin B until disk diffusion test modifications are sanctioned and published by the NCCLS...
  22. ncbi Relevance of mutations in the TLR4 receptor in patients with gram-negative septic shock
    Eva Lorenz
    Pulmonary and Critical Care Medicine, Duke University Medical Center, Research Drive, Room 275 MSRB, DUMC Box 2629, Durham, NC 27710, USA
    Arch Intern Med 162:1028-32. 2002
    ..We recently identified a common polymorphism in toll-like receptor 4 (TLR4) that is associated with hyporesponsiveness to inhaled endotoxin or lipopolysaccharide in humans...
  23. ncbi Emerging importance of multidrug-resistant Acinetobacter species and Stenotrophomonas maltophilia as pathogens in seriously ill patients: geographic patterns, epidemiological features, and trends in the SENTRY Antimicrobial Surveillance Program (1997-1999
    A C Gales
    University of Iowa College of Medicine, Iowa City, Iowa, USA, and Division of Infectious Diseases, Universidade Federal de Sao Paulo, Sao Paulo, Brazil
    Clin Infect Dis 32:S104-13. 2001
    ..maltophilia isolates observed in this study emphasize the importance of local surveillance in determining the most adequate therapy for acinetobacter and S. maltophilia infections and the possible clonal, epidemic nature of occurrence...
  24. pmc Extended-spectrum beta-lactamases in the 21st century: characterization, epidemiology, and detection of this important resistance threat
    P A Bradford
    Wyeth Ayerst Research, Pearl River, New York 10965, USA
    Clin Microbiol Rev 14:933-51, table of contents. 2001
    ..They have also been found in other Enterobacteriaceae strains and Pseudomonas aeruginosa. Strains expressing these beta-lactamases will present a host of therapeutic challenges as we head into the 21st century...
  25. pmc Type I interferon signaling is required for activation of the inflammasome during Francisella infection
    Thomas Henry
    Department of Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA
    J Exp Med 204:987-94. 2007
    ..This connection underscores the importance of the cytosolic recognition of pathogens and highlights how multiple innate immunity pathways interact before commitment to critical host responses...
  26. ncbi Association of Type III secretion genes with virulence of Aeromonas salmonicida subsp. salmonicida
    Sarah E Burr
    Institute of Veterinary Bacteriology, University of Berne, Laenggassstrasse 122, 3012 Berne, Switzerland
    Dis Aquat Organ 57:167-71. 2003
    ..The findings from both the in vitro and in vivo experiments suggest that the presence of Type III secretion genes is associated with the virulence of this important fish pathogen...
  27. ncbi Antimicrobial susceptibility of uncommonly isolated non-enteric Gram-negative bacilli
    Helio S Sader
    JMI Laboratories Inc, 345 Beaver Kreek Centre, Suite A, North Liberty, IA 52317, USA
    Int J Antimicrob Agents 25:95-109. 2005
    ....
  28. ncbi Infectious keratitis manifesting as a white plaque on the cornea
    Beom Jin Cho
    Department of Ophthalmology, College of Medicine, University of Ulsan, Asan Medical Center, 388 1, Poongnap dong, Songpa Gu, Seoul 138 040, South Korea
    Arch Ophthalmol 120:1091-3. 2002
  29. pmc Class 1 integrons increase trimethoprim-sulfamethoxazole MICs against epidemiologically unrelated Stenotrophomonas maltophilia isolates
    Raquel Barbolla
    Departamento de Microbiologia, Parasitologia e Inmunologia, Facultad de Medicina, Universidad de Buenos Aires, Argentina
    Antimicrob Agents Chemother 48:666-9. 2004
    ..These results support not only the higher spread of class 1 integrons compared to other mechanisms but also the potential limitation of using trimethoprim-sulfamethoxazole for therapy of severe S. maltophilia infections...
  30. ncbi Acute postoperative Alcaligenes xylosoxidans endophthalmitis
    David J Weissgold
    Department of Ophthalmology, Unit of Infectious Diseases, University of Vermont College of Medicine Fletcher Allen Health Care, 1 South Prospect Street, Burlington, VT 05401, USA
    Retina 23:578-80. 2003
  31. ncbi [Epidemiology of nosocomial infections due to Pseudomonas aeruginosa, Burkholderia cepacia and Stenotrophomonas maltophilia]
    P Berthelot
    Unité d hygiène interhospitalière, Service des Maladies Infectieuses, CHU de Saint Etienne, 42055 Saint Etienne, France
    Pathol Biol (Paris) 53:341-8. 2005
    ....
  32. ncbi Epidemiological relationships between Aeromonas strains isolated from symptomatic children and household environments as determined by ribotyping
    A Demarta
    Istituto Cantonale Batteriosierologico, Laboratory of Microbial Ecology, University of Geneva, Lugano, Switzerland
    Eur J Epidemiol 16:447-53. 2000
    ....
  33. ncbi Attributable mortality of Stenotrophomonas maltophilia bacteremia
    Esin Senol
    Department of Medicine, Division of Geographic Medicine and Infectious Diseases, New England Medical Center and Tufts University School of Medicine, Boston, MA, USA
    Clin Infect Dis 34:1653-6. 2002
    ..7%) and mortality risk ratio (an 8-fold increase) of S. maltophilia bacteremia. The attributable mortality rate for S. maltophilia bacteremia is similar to the attributable mortality rate for other nosocomial bloodstream infections...
  34. ncbi Identification of enteric pathogens by heat shock protein 60 kDa (HSP60) gene sequences
    Rebecca S Y Wong
    Division of Infectious Diseases, Vancouver Hospital Health Sciencs Center, BC, Canada
    FEMS Microbiol Lett 206:107-13. 2002
    ..jejuni and C. coli, or between Salmonella and Shigella or Escherichia coli...
  35. pmc Identification by 16S ribosomal RNA gene sequencing of Arcobacter butzleri bacteraemia in a patient with acute gangrenous appendicitis
    S K P Lau
    Department of Microbiology, The University of Hong Kong, University Pathology Building, Queen Mary Hospital, Hong Kong
    Mol Pathol 55:182-5. 2002
    ..The literature on arcobacter bacteraemia and arcobacter infections associated with appendicitis was reviewed...
  36. ncbi Two decades of imipenem therapy
    A C Rodloff
    Institut for Medical Microbiology and Epidemiology of Infectious Diseases, University of Leipzig, D 04103 Leipzig, Germany, and Institut Clínic de Pneumologia i Cirurgia Toràcica, Hospital Clinic de Barcelona, Spain
    J Antimicrob Chemother 58:916-29. 2006
    ..We review the factors that continue to make imipenem as appropriate an agent for de-escalation therapy now as it was 20 years ago...
  37. pmc Isolation, identification, and molecular characterization of strains of Photorhabdus luminescens from infected humans in Australia
    M M Peel
    Microbiological Diagnostic Unit, The University of Melbourne, Parkville, Victoria 3052, Australia
    J Clin Microbiol 37:3647-53. 1999
    ..This is the first report of the isolation of P. luminescens from infected humans in Australia and the second report of the isolation of this species from infected humans worldwide...
  38. pmc Capnocytophaga ochracea: characterization of a plasmid-encoded extended-spectrum TEM-17 beta-lactamase in the phylum Flavobacter-bacteroides
    A Rosenau
    Département de Microbiologie Médicale et Moléculaire, Centre Hospitalier Universitaire Bretonneau, 37044 Tours Cedex, France
    Antimicrob Agents Chemother 44:760-2. 2000
    ....
  39. pmc Clinical and economic impact of common multidrug-resistant gram-negative bacilli
    Christian G Giske
    Clinical Microbiology L2 02, Karolinska Institutet MTC, Karolinska University Hospital Solna, Stockholm SE 17176, Sweden
    Antimicrob Agents Chemother 52:813-21. 2008
  40. ncbi The increase in carbapenem use and emergence of Stenotrophomonas maltophilia as an important nosocomial pathogen
    S C Sanyal
    Department of Laboratory Medicine, Ibn Sina Hospital, Kuwait
    J Chemother 11:28-33. 1999
    ..The study thus indicates that carbapenem use in a hospital environment may result in emergence of nosocomial infections due to multiresistant S. maltophilia in high risk patients with very limited choice of antibiotics for therapy...
  41. ncbi A prospective incidence study of nosocomial infections in a neonatal care unit
    Mireya Urrea
    Quality Service Infection Hospital Program, Hospital Sant Joan de Deu de Barcelona, Barcelona, Spain
    Am J Infect Control 31:505-7. 2003
    ..However, nosocomial infections (NI) still represent an important cause of morbidity and mortality in this population...
  42. pmc Characterization of Aeromonas spp. isolated from humans with diarrhea, from healthy controls, and from surface water in Bangladesh
    I Kuhn
    Microbiology and Tumor Biology Centre, Karolinska Institute, Stockholm, Sweden
    J Clin Microbiol 35:369-73. 1997
    ..Thus, the HG1/BD-2 type may represent a pathogenic A. hydrophila type that is able to produce diarrhea in humans...
  43. ncbi Predicting bacteremia in children with fever and chemotherapy-induced neutropenia
    Roland A Ammann
    Division of Pediatric Hematology and Oncology, Department of Pediatrics, University of Bern, Bern, Switzerland
    Pediatr Infect Dis J 23:61-7. 2004
    ..The purpose of this study was to develop an algorithm predicting the risk of bacteremia and Gram-negative bacteremia in children and adolescents with fever and neutropenia, based on information accessible at presentation...
  44. pmc Brachyspira pilosicoli bloodstream infections: case report and review of the literature
    Lilia Bait-Merabet
    Service de Bactériologie Virologie Hygiène, C, H, U, Henri Mondor, Assistance Publique Hopitaux de Paris, Creteil, France
    Ann Clin Microbiol Antimicrob 7:19. 2008
    ..Finally, difficulties in rapid and accurate diagnosis of B. pilosicoli bloodstream infections, in vitro antimicrobial susceptibility of human clinical isolates, and therapeutic options are discussed...
  45. ncbi [A case of endogenous Aeromonas hydrophila endophthalmitis]
    Tomonori Tamura
    Department of Ophthalmology, Kyorin University School of Medicine, 6 20 2 Shinkawa, Mitaka 181 8611, Japan
    Nihon Ganka Gakkai Zasshi 107:535-7. 2003
    ..To our knowledge, there have been no reports of A. hydrophila endophthalmitis in Japan. We report a case of endogenous endophthalmitis caused by Aeromonas hydrophila...
  46. pmc Molecular epidemiology of Stenotrophomonas maltophilia isolated from clinical specimens from patients with cystic fibrosis and associated environmental samples
    M Denton
    Department of Microbiology, St James s University Hospital, Leeds, United Kingdom
    J Clin Microbiol 36:1953-8. 1998
    ....
  47. ncbi Frontal and stealth attack strategies in microbial pathogenesis
    D Scott Merrell
    Uniformed Services University of the Health Sciences, Department of Microbiology and Immunology, 4301 Jones Bridge Road, Bethesda, Maryland 20814, USA
    Nature 430:250-6. 2004
    ..This highlights the relevance of continuing to probe the mechanisms used by microorganisms to cause disease, and emphasizes the need for new model systems to advance our understanding of host-pathogen interactions...
  48. ncbi Bacteremia in febrile Malawian children: clinical and microbiologic features
    A L Walsh
    Wellcome Trust Research Laboratories, University of Malawi, Blantyre
    Pediatr Infect Dis J 19:312-8. 2000
    ..There are no published data for the incidence or etiology of childhood bacteremia in Malawi. We describe the clinical and microbiologic features of children admitted to hospital from whom blood cultures yielded bacterial pathogens...
  49. pmc Pantoea agglomerans, a plant pathogen causing human disease
    Andrea T Cruz
    Department of Pediatrics, Sections of Infectious Disease, Baylor College of Medicine, Houston, TX, USA
    J Clin Microbiol 45:1989-92. 2007
    ..P. agglomerans was most associated with penetrating trauma by vegetative material and catheter-related bacteremia...
  50. ncbi Endogenous bacterial endophthalmitis: a 17-year prospective series and review of 267 reported cases
    Timothy L Jackson
    Academic Department of Ophthalmology, Medical Eye Unit, St Thomas Hospital, London, UK
    Surv Ophthalmol 48:403-23. 2003
    ..The outcome of endogenous bacterial endophthalmitis has not improved in 55 years and clinicians need to have a high level of awareness of this commonly misdiagnosed condition...
  51. ncbi Achromobacter xylosoxidans bacteremia: a 10-year analysis of 54 cases
    J Gomez-Cerezo
    Department of Internal Medicine, Hospital Universitario La Paz, Po Castellana 261, 28046 Madrid, Spain
    Eur J Clin Microbiol Infect Dis 22:360-3. 2003
    ..Patients were probably contaminated when healthcare workers manipulated the intravenous catheters without wearing gloves...
  52. ncbi Antimicrobial therapy for Stenotrophomonas maltophilia infections
    A C Nicodemo
    Department of Infectious Diseases, University of Sao Paulo Medical School, Sao Paulo, SP, Brazil
    Eur J Clin Microbiol Infect Dis 26:229-37. 2007
    ..This review describes the main resistance mechanisms, the in vitro susceptibility profile, and treatment options for S. maltophilia infections...
  53. ncbi The new beta-lactamases
    George A Jacoby
    Department of Infectious Diseases, Lahey Clinic, Burlington, Mass 01805, USA
    N Engl J Med 352:380-91. 2005
  54. pmc First report of bacteremia by Asaia bogorensis, in a patient with a history of intravenous-drug abuse
    Tamara Tuuminen
    Division of Clinical Microbiology, Helsinki University Hospital, HUSLAB, Haartmaninkatu 3, P O BOX 400, Fl 00029 HUS, Helsinki, Finland
    J Clin Microbiol 44:3048-50. 2006
    ..bogorensis was identified by sequencing the 16S rRNA gene. The isolate was exceptionally resistant to almost all antibiotics that are routinely tested for gram-negative rods but was susceptible to netilmicin, gentamicin, and doxycycline...
  55. ncbi Antimicrobial resistance among uropathogens that cause community-acquired urinary tract infections in Antananarivo, Madagascar
    Frédérique Randrianirina
    Institut Pasteur de Madagascar, BP 1274, Antananarivo 101, Madagascar
    J Antimicrob Chemother 59:309-12. 2007
    ..This poses a real problem for the treatment of community-acquired urinary tract infections (UTIs) in Madagascar...
  56. pmc Global spread of multiple aminoglycoside resistance genes
    Kunikazu Yamane
    National Institute of Infectious Diseases, Tokyo, Japan
    Emerg Infect Dis 11:951-3. 2005
    ..ArmA, which had been identified exclusively in Europe, was also found in several gram-negative pathogenic bacilli isolated in Japan, suggesting global dissemination of hazardous multiple aminoglycoside resistance genes...
  57. pmc Unusual cause of infective discitis in an adolescent
    M K Sayana
    Department of Orthopaedics, Fairfield General Hospital, Rochdale Old Road, Bury, Lancashire BL9 7TA, UK
    Postgrad Med J 79:237-8. 2003
    ..This patient responded well to co-amoxiclav and recovered without any surgical intervention...
  58. ncbi Recent advances in molecular epidemiology and detection of Taylorella equigenitalis associated with contagious equine metritis (CEM)
    Motoo Matsuda
    Laboratory of Molecular Biology, School of Environmental Health Sciences, Azabu University, Fuchinobe 1 17 71, Sagamihara 229 8501, Japan
    Vet Microbiol 97:111-22. 2003
    ..equigenitalis genome would be useful to help elucidate the pathogenic virulence and transmission mechanisms associated with the important equine pathogen associated with CEM...
  59. ncbi Increasing prevalence of vancomycin-resistant enterococci, and cefoxitin-, imipenem- and fluoroquinolone-resistant gram-negative bacilli: a KONSAR study in 2002
    Kyungwon Lee
    Department of Laboratory Medicine, Research Institute of Bacterial Resistance, Yonsei University College of Medicine, 134 Shinchon dong, Seodaemun gu, Seoul 120 752, Korea
    Yonsei Med J 45:598-608. 2004
    ..aeruginosa and Acinetobacter spp. increased gradually, and imipenem- resistant E. coli and K. pneumoniae appeared for the first time. Continued surveillance is required to prevent further spread of these serious resistances...
  60. ncbi Extended-spectrum beta-lactamases: implications for the clinical microbiology laboratory, therapy, and infection control
    Enno Stürenburg
    Institut für Infektionsmedizin, Universitatsklinikum Hamburg Eppendorf, Hamburg, Germany
    J Infect 47:273-95. 2003
    ..Therapeutic options and potential strategies for dealing with this growing problem are also discussed in this article...
  61. pmc Pantoea agglomerans as a cause of septic arthritis after palm tree thorn injury; case report and literature review
    A Kratz
    Pediatrics Department D, Soroka University Medical Center and Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheba, Israel
    Arch Dis Child 88:542-4. 2003
    ..We also emphasise the efficacy of ultrasound examination in these cases to identify the presence and location of a plant thorn...
  62. ncbi Clinical gram-positive sepsis: does it fundamentally differ from gram-negative bacterial sepsis?
    S M Opal
    Brown University School of Medicine, Povidence, RI, USA
    Crit Care Med 27:1608-16. 1999
    ..To review the basic differences between gram-positive and gram-negative sepsis and to assess the effect of these differences on current and future therapeutic strategies for sepsis...
  63. ncbi Resistance in nonfermenting gram-negative bacteria: multidrug resistance to the maximum
    John E McGowan
    Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia 30322, USA
    Am J Med 119:S29-36; discussion S62-70. 2006
    ..Improved antibiotic stewardship and infection-control measures will be needed to prevent or slow the emergence and spread of multidrug-resistant, nonfermenting gram-negative bacilli in the healthcare setting...
  64. ncbi Lipid A diversity and the innate host response to bacterial infection
    R P Darveau
    Department of Periodontics, Box 357444, School of Dentistry, Universityof Washington, Seattle, WA 98195 7444, USA
    Curr Opin Microbiol 1:36-42. 1998
    ..Recent data indicate that bacteria can regulate this molecule in response to different host microenvironments. Host factors that induce lipid A modifications and the resultant changes in host response remain to be determined...
  65. ncbi Meningitis due to Capnocytophaga canimorsus after receipt of a dog bite: case report and review of the literature
    Gwenael Le Moal
    Service de Medecine Interne et Maladies Infectieuses, Centre Hospitalier Universitaire La Miletrie, 86021 Poitiers, France
    Clin Infect Dis 36:e42-6. 2003
    ..canimorsus meningitis very low when compared with the rate for C. canimorsus septicemia (5% vs. 30%)...
  66. ncbi Meropenem by continuous versus intermittent infusion in ventilator-associated pneumonia due to gram-negative bacilli
    Leonardo Lorente
    Intensive Care Unit, Hospital Universitario de Canarias, Tenerife, Spain
    Ann Pharmacother 40:219-23. 2006
    ..However, limited data exist on the clinical efficacy of meropenem administered by continuous infusion...
  67. ncbi Osteomyelitis and secondary septic arthritis caused by Sphingomonas paucimobilis
    R M Charity
    Infection 33:93-5. 2005
    ..This case highlights the need to thoroughly investigate musculoskeletal pain in the immunocompromised patient in order to exclude an infection as a cause...
  68. ncbi Stenotrophomonas maltophilia bacteremia in adults: four years' experience in a medical center in northern Taiwan
    Wei Sheng Wang
    Division of Infectious Diseases, Department of Medicine, Mackay Memorial Hospital, Taipei, Taiwan, ROC
    J Microbiol Immunol Infect 37:359-65. 2004
    ..maltophilia is normally sensitive should be considered in selecting empiric therapy...
  69. pmc Ecoepidemiology of Laribacter hongkongensis, a novel bacterium associated with gastroenteritis
    Jade L L Teng
    Department of Microbiology, University of Hong Kong, Hong Kong
    J Clin Microbiol 43:919-22. 2005
    ..Comparing the pulsed-field gel electrophoresis patterns of fish and patient isolates revealed that most patient isolates were clustered together, suggesting that some clones could be more virulent...
  70. ncbi Recurrent Sphingomonas paucimobilis -bacteraemia associated with a multi-bacterial water-borne epidemic among neutropenic patients
    O Perola
    Department of Clinical Microbiology, Kuopio University Hospital, Kuopio, Finland
    J Hosp Infect 50:196-201. 2002
    ..paucimobilis clones in the hospital environment. This link also explained the multi-microbial nature of the outbreak...
  71. ncbi Prevalence, serotype distribution, antibiotic susceptibility and genetic profiles of mesophilic Aeromonas species isolated from hospitalized diarrhoeal cases in Kolkata, India
    S Sinha
    National Institute of Cholera and Enteric Diseases, Beliaghata, Kolkata 700010, India
    J Med Microbiol 53:527-34. 2004
    ..Different species of Aeromonas and different clones of Aeromonas species seem to be associated with hospitalized cases of diarrhoea in Kolkata, India...
  72. ncbi Polymyxin B sulfate and colistin: old antibiotics for emerging multiresistant gram-negative bacteria
    M E Evans
    Department of Internal Medicine, College of Medicine, University of Kentucky, Lexington 40536, USA
    Ann Pharmacother 33:960-7. 1999
    ..Gram-negative bacteria that are resistant to the aminoglycosides, beta-lactams, and fluoroquinolones are becoming more common. These bacteria are often susceptible to the polymyxins...
  73. ncbi Increasing threat of Gram-negative bacteria
    G W Waterer
    Department of Medicine, University of Western Australia, Royal Perth Hospital, Perth, Western Australia
    Crit Care Med 29:N75-81. 2001
    ..The combination of an increasing population at risk, and the natural virulence and adaptability of Gram-negative bacteria guarantees that critical care physicians will face a persistent and increasing challenge from these pathogens...
  74. pmc Randomized controlled trial of moxifloxacin compared with piperacillin-tazobactam and amoxicillin-clavulanate for the treatment of complicated intra-abdominal infections
    Mark A Malangoni
    Case Western Reserve University, MetroHealth Medical Center, Cleveland, OH 44109 1998, USA
    Ann Surg 244:204-11. 2006
    ....
  75. ncbi Development and application of a nested PCR to monitor brood stock salmonid ovarian fluid and spleen for detection of the fish pathogen Flavobacterium psychrophilum
    A Baliarda
    Laboratoire de Microbiologie, ENITA Bordeaux, 1 cr G de Gaulle, 33175 Gradignan, France
    J Appl Microbiol 92:510-6. 2002
    ..To develop a nested PCR to detect Flavobacterium psychrophilum based on the intergenic spacer region 16S-23S rRNA and in 16S rRNA for analysis of brood stock salmonid fish samples...
  76. ncbi Veillonella montpellierensis sp. nov., a novel, anaerobic, Gram-negative coccus isolated from human clinical samples
    Estelle Jumas-Bilak
    Laboratoire de Bacteriologie virologie, Faculte de Pharmacie, 15 Avenue Charles Flahault, BP 14491, 34060 Montpellier 5, France
    Int J Syst Evol Microbiol 54:1311-6. 2004
    ..The type strain of the species is ADV 281.99T (=CIP 107992T=CCUG 48299T)...
  77. pmc Microbiology of airway disease in a cohort of patients with cystic fibrosis
    Antonietta Lambiase
    Department of Biology and Pathology Cellular and Molecular Luigi Califano, University of Naples Federico II, Italy
    BMC Infect Dis 6:4. 2006
    ....
  78. pmc Genome sequence analysis of the emerging human pathogenic acetic acid bacterium Granulibacter bethesdensis
    David E Greenberg
    Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, U S Department of Health and Human Services, Bethesda, MD 20892 1684, USA
    J Bacteriol 189:8727-36. 2007
    ..G. bethesdensis is a genetically diverse emerging human pathogen that may have recently acquired virulence factors new to this family of organisms...
  79. pmc Internalization and phagosome escape required for Francisella to induce human monocyte IL-1beta processing and release
    Mikhail A Gavrilin
    Davis Heart and Lung Research Institute, Department of Molecular Virology and Immunology and Medical Genetics, and Center for Microbial Interface Biology, Ohio State University, Columbus, OH 43210, USA
    Proc Natl Acad Sci U S A 103:141-6. 2006
    ..These findings demonstrate that Francisella organisms efficiently induce IL-1beta processing and release in fresh monocytes by means of a sensing system that requires the uptake of live bacteria capable of phagosome escape...
  80. ncbi Transfusion-transmitted bacterial infection in the United States, 1998 through 2000
    M J Kuehnert
    Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Transfusion 41:1493-9. 2001
    ..Bacterial contamination of blood components can result in transfusion-transmitted infection, but the risk is not established...
  81. ncbi Potentially multidrug-resistant non-fermentative Gram-negative pathogens causing nosocomial pneumonia
    Anna M Ferrara
    Department of Haematological, Pneumological, Cardiovascular and Surgical Sciences, University of Pavia, IRCCS Policlinico San Matteo, Padiglione Forlanini, Viale Taramelli 5, 27100 Pavia, Italy
    Int J Antimicrob Agents 27:183-95. 2006
    ..aeruginosa. Newer fluoroquinolones and some tetracyclines may be alternative drugs both for MDR S. maltophilia and A. baumannii. However, large-scale controlled clinical trials are needed to confirm these promising therapeutic options...
  82. ncbi Granulibacter bethesdensis isolated in a child patient with chronic granulomatous disease
    F C Rodríguez López
    Microbiology Service, Reina Sofia University Hospital, Cordoba, Spain
    J Infect 57:275-7. 2008
    ..All microbiological analyses were negative, except two blood cultures from which the novel bacterium Granulibacter bethesdensis was isolated...
  83. ncbi Escape from immune surveillance by Capnocytophaga canimorsus
    Hwain Shin
    Biozentrum, University of Basel, Basel, Switzerland
    J Infect Dis 195:375-86. 2007
    ..These results highlight passive and active mechanisms of immune evasion by C. canimorsus, which may explain its capacity to escape from the host immune system...
  84. ncbi Stenotrophomonas maltophilia: the significance and role as a nosocomial pathogen
    E Senol
    Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Gazi University, Besevler, Ankara, Turkey
    J Hosp Infect 57:1-7. 2004
    ....
  85. pmc Capnocytophaga canimorsus mycotic abdominal aortic aneurysm: why the mailman is afraid of dogs
    David M Tierney
    Abbott Northwestern Hospital, Graduate Medical Education 11135, 800 East 28th Street, Minneapolis, MN 55407 3799, USA
    J Clin Microbiol 44:649-51. 2006
    ..The exposure occurred after his dog scratched his arm and subsequently licked the wound. A review of C. canimorsus, a rarely pathogenic but potentially devastating bacterium, is also presented...
  86. pmc Prosthetic mitral valve endocarditis due to Ochrobactrum anthropi: case report
    M P Romero Gómez
    Department of Microbiology and Parasitology, La Paz University Hospital Paseo de la Castellana, 261, 28046 Madrid, Spain
    J Clin Microbiol 42:3371-3. 2004
    ..To our knowledge, only two cases of O. anthropi endocarditis have been reported in the medical literature...
  87. ncbi Antimicrobial susceptibility of Aeromonas spp., Vibrio spp. and Plesiomonas shigelloides isolated in the Philippines and Thailand
    R P Maluping
    Int J Antimicrob Agents 25:348-50. 2005
  88. ncbi Molecular cloning and expression analysis of a hepcidin antimicrobial peptide gene from turbot (Scophthalmus maximus)
    Song Lin Chen
    Key Lab for Sustainable Utilization of Marine Fisheries Resources, Ministry of Agriculture, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Nanjing Road 106, Qingdao 266071, China
    Fish Shellfish Immunol 22:172-81. 2007
    ..The hepcidin transcripts were detected in turbot embryonic cell line (TEC). Challenge of TEC cells with the pathogenic bacteria significantly elevated hepcidin mRNA levels...
  89. ncbi Nonfermentative gram-negative bacilli in cancer patients: increasing frequency of infection and antimicrobial susceptibility of clinical isolates to fluoroquinolones
    Kenneth V I Rolston
    Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas, M D Anderson Cancer Center, Houston, TX 77030, USA
    Diagn Microbiol Infect Dis 51:215-8. 2005
    ..The newer quinolones (gatifloxacin, moxifloxacin, and garenoxacin) had better activity than ofloxacin, levofloxacin, and ciprofloxacin, against many other nonfermenters (Stenotrophomonas maltophilia, P. fluorescens, and P. putida)...
  90. pmc Atypical infections in tsunami survivors
    Christian Garzoni
    University Hospitals of Geneva, Geneva, Switzerland
    Emerg Infect Dis 11:1591-3. 2005
    ..Treating these infections is challenging from a clinical and microbiologic point of view...
  91. ncbi Ochrobactrum anthropi endocarditis and septic shock in a patient with no prosthetic valve or rheumatic heart disease: case report and review of the literature
    D Ozdemir
    Department of Clinical Microbiology and Infectious Diseases, Abant Izzet Baysal University Duzce Medical School, Duzce, Turkey
    Jpn J Infect Dis 59:264-5. 2006
    ..In this paper, we report a case of O. anthropi endocarditis and septic shock in a patient who had no prosthetic valve or rheumatic heart disease, in contrast to previous reports...
  92. ncbi Role of Stenotrophomonas maltophilia in hospital-acquired infection
    W J Looney
    Department of Clinical Microbiology, Institute for Infectious Diseases, University of Bern, Switzerland
    Br J Biomed Sci 62:145-54; quiz 1 p following 154. 2005
    ..Future therapeutic development may be directed against biofilms and efflux mechanisms, in order to render the organism more susceptible to available antimicrobial agents...
  93. ncbi Defining the need for new antimicrobials: clinical and economic implications of resistance in the hospitalised patient
    C Andrew DeRyke
    Center for Anti Infective Research and Development, Hartford Hospital, 80 Seymour Street, Hartford, CT 06102, USA
    Expert Opin Pharmacother 6:873-89. 2005
    ..Despite these efforts, new antimicrobials with novel mechanisms of action are eagerly anticipated to extend the current armamentarium against the growing population of multi-drug-resistant pathogens...
  94. ncbi Comparison of pharmacodynamic target attainment between healthy subjects and patients for ceftazidime and meropenem
    Joseph L Kuti
    Center for Anti Infective Research and Development, Hartford Hospital, Hartford, Connecticut 06102, USA
    Pharmacotherapy 25:935-41. 2005
    ..To compare the pharmacodynamics of two beta-lactams--ceftazidime and meropenem--in healthy subjects versus patients...
  95. pmc Circulating inflammatory mediators during start of fever in differential diagnosis of gram-negative and gram-positive infections in leukopenic rats
    Eva Tavares
    Unidad de Investigacion, Laboratorio de Farmacología Clinica y Experimental, Hospital Universitario Virgen de Valme, Seville, Spain
    Clin Diagn Lab Immunol 12:1085-93. 2005
    ..These results suggest that the use of the analyzed serum markers at an early stage of fever could give useful information for the clinician for excluding gram-negative from gram-positive infections...
  96. ncbi Assessment of pathogen occurrences and resistance profiles among infected patients in the intensive care unit: report from the SENTRY Antimicrobial Surveillance Program (North America, 2001)
    Jennifer M Streit
    The JONES Group JMI Laboratories Inc, 345 Beaver Kreek Centre, Suite A, North Liberty, IW 52317, USA
    Int J Antimicrob Agents 24:111-8. 2004
    ..Cefepime and the carbapenems (imipenem or meropenem) for Gram-negative isolates and linezolid for Gram-positive isolates, provided the broadest spectrum of in vitro activity against contemporary ICU pathogens in North America...
  97. ncbi Asaia bogorensis peritonitis identified by 16S ribosomal RNA sequence analysis in a patient receiving peritoneal dialysis
    Richard W Snyder
    Renal, Electrolyte, and Hypertension Division, Department of Medicine, University of Pennsylvania, Philadelphia, PA 19131, USA
    Am J Kidney Dis 44:e15-7. 2004
    ..This organism was identified by sequence analysis of the 16S ribosomal RNA gene. Unusual microbial agents may cause peritonitis, and molecular microbiological techniques are important tools for identifying these agents...
  98. ncbi Economic burden associated with multi-resistant Gram-negative organisms compared with that for methicillin-resistant Staphylococcus aureus in a university teaching hospital
    F Daxboeck
    Division of Hospital Hygiene, Clinical Institute of Hygiene and Medical Microbiology, Vienna General Hospital, Medical University Vienna, Wahringer Gurtel 18 20, A 1090 Vienna, Austria
    J Hosp Infect 62:214-8. 2006
    ..01). This study is limited by being retrospective and having charge-based costings. However, it suggests that the hospital costs of patients with MR-GNB are substantial and may be greater than those of patients with MRSA...
  99. ncbi Outbreak of Aeromonas hydrophila wound infections associated with mud football
    Hassan Vally
    Communicable Disease Control Branch, Department of Health, Perth, Australia
    Clin Infect Dis 38:1084-9. 2004
    ..A. hydrophila was subsequently isolated from a water sample obtained from the river. This is the first published report of an outbreak of A. hydrophila wound infections associated with exposure to mud...
  100. ncbi Health implications of antimicrobial resistance for patients with acute kidney injury and bloodstream infection
    Eric A J Hoste
    Intensive Care Department, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium
    Infect Control Hosp Epidemiol 28:1107-10. 2007
    ..We found that infection with an antimicrobial-resistant organism did not adversely affect clinical outcome in this specific cohort, which already has a high mortality rate...
  101. ncbi Synergy of colistin with rifampin and trimethoprim/sulfamethoxazole on multidrug-resistant Stenotrophomonas maltophilia
    Evangelos J Giamarellos-Bourboulis
    4th Department of Internal Medicine, University of Athens, Medical School, Athens, Greece
    Diagn Microbiol Infect Dis 44:259-63. 2002
    ..maltophilia is significantly inhibited by the interaction of colistin and rifampin and to a lesser extent of colistin and trimethoprim/sulfamethoxazole. These results merit further study in both the animal model and the clinical setting...

Research Grants64

  1. Molecular Basis of Bacterial Quorum Sensing Gene Regulation
    MAIR E CHURCHILL; Fiscal Year: 2010
    ..abstract_text> ..
  2. Spatial Control and Function of Nuclear Superoxide in LPS-mediated Cell Signaling
    NETANYA YEHUDIT SPENCER; Fiscal Year: 2013
    ..The proposed research will enhance our understanding of LPS-mediated injury and may lead to new therapeutic approaches for endotoxin-mediated sepsis. ..
  3. Chemoprotection Against Aminoglycoside-Induced Ototoxicity
    Julian A Simon; Fiscal Year: 2013
    ..Studies in this proposal will develop more potent protective compounds, identify how these compounds work and provide preliminary data for their development as drugs. ..
  4. TLR4 Mutations: Molecular Mechanisms of Impaired LPS Sensitivity
    Andrei E Medvedev; Fiscal Year: 2010
    ..by applicant):TLR4, the predominant signaling receptor for LPS, is critical for host defense against Gram negative bacterial infections. Two point mutations, D299G and T399I, in the ectodomain of TLR4 have been associated with a blunted ..
  5. NW Research Center for Excellence in Biodefense and Emerging Infectious Diseases
    Samuel I Miller; Fiscal Year: 2013
    ..abstract_text> ..
  6. Antibacterial Resistance Leadership Group (ARLG)
    Vance G Fowler; Fiscal Year: 2013
    ..trial of new anti-infectives (either new agent or new dosing regimen of existing agent) for MDR-Gram negative bacterial infections;2) to define shorter course, narrow-spectrum therapeutic regimens for common infections as a ..
  7. Novel adjunctive therapy for drug resistant Gram-negative pathogens
    ROBERT ERNEST WILLIAM HANCOCK; Fiscal Year: 2013
    ..demonstrated that some of these peptides suppress the formation of biofilms by a number of serious Gram negative bacterial infections. Here we are pursuing this strategy as an adjunct to conventional antibiotic therapy...
  8. Functional similarities in renal and cochlear epithelia
    PETER STEYGER; Fiscal Year: 2004
    ....
  9. MAST CELLS IN PULMONARY INFLAMMATION
    SOMAN ABRAHAM; Fiscal Year: 1999
    Although the pulmonary inflammatory disease following aerobic gram negative bacterial infections is severe and sometimes lethal, the nature of the specific host cells that initiate the inflammatory process is unclear...
  10. Gamma Delta T Cells in Anti-Bacterial Host Defense
    Thomas Moore; Fiscal Year: 2005
    ..pneumoniae bacteremia. These studies will provide insights for the development of therapeutic modalities aimed at augmenting host responses, resulting in enhanced resolution of bacterial infections. ..
  11. OUTER MEMBRANE SECRETION MECHANISM FOR AUTOTRANSPORTER PROTEINS
    PATRICIA LOUISE CLARK; Fiscal Year: 2013
    ....
  12. MAST CELLS IN INNATE IMMUNITY AGAINST BACTERIAL INFECTIO
    Ravi Malaviya; Fiscal Year: 2001
    ..Specific Aim #1 will test the ability of mast cells to mount a response against gram negative bacterial infections, and will characterize the signal transduction events triggered by the interaction of gram negative ..
  13. Dissecting the roles of superchaperones in type III secretion
    CAMMIE LESSER; Fiscal Year: 2012
    ..Insights gained from these studies will likely result in generating new directions for the development of novel agents for the treatment of a variety of diseases associated with Gram-negative bacterial infections. ..
  14. ASSAY TO RAPIDLY DETECT ENDOTOXIN IN WHOLE BLOOD
    Nathan Smith; Fiscal Year: 1991
    ..Use of this assay may also prove to be valuable in protecting the supply of donated blood and blood products from contamination by endotoxin...
  15. SERINE PROTEINASES & LUNG HOST DEFENSE AGAINST BACTERIA
    Azzaq Belaaouaj; Fiscal Year: 2004
    ..Using mice deficient in NE and CG, we have demonstrated that NE, but not CG, reduces mortality from Gram negative bacterial infections. To date, the antibacterial role of PR 3 has not been clarified in vivo...
  16. NATURAL CYTOTOXIC ACTIVITY & TUMORIGENESIS
    PAUL PATEK; Fiscal Year: 1990
    ..Such relationships would mark a critical prediction of anti-tumor surveillance hypotheses...
  17. MOLECULAR PATHOLOGY OF PHAGOCYTOSIS IN SEPSIS
    Deborah Schiff; Fiscal Year: 2000
    ..Information obtained from these studies will help answer important questions pertaining to CD14 and its role in host defense, and may contribute to the development of new strategies for the treatment of Gram-negative infections. ..
  18. CREB TRANSCRIPTION FACTOR IN LPS TREATED MACROPHAGES
    STEVE WEINSTEIN; Fiscal Year: 1999
    ..recognize conserved structural componentsof LPS to facilitate effective anti-microbial responses to Gram negative bacterial infections. The objective of this research is to understand how LPS-elicited gene regulation is mediated by ..
  19. Role of Inter-alpha Inhibitors in Anthrax Intoxication
    Steven Opal; Fiscal Year: 2007
    ..Our research is focused on the development of a new and safe treatment based on the ability of inter-alpha proteins to prevent the fatal consequences of anthrax infection. [unreadable] [unreadable] [unreadable] [unreadable]..
  20. Prevention of Healthcare-Associated Drug-Resistant GNR
    Lisa Maragakis; Fiscal Year: 2006
    ..Maragakis with the skills she needs to develop into an independent clinical investigator in epidemiologic research for the prevention of healthcare-associated infections. ..
  21. Susceptibility Testing, Treatment Choices, and Outcomes of MDR-GNB Infections
    Lisa Maragakis; Fiscal Year: 2009
    ..This research is designed to better understand how providers use information from various microbiology laboratory testing methods to choose treatments and to identify strategies that lead to the best patient outcomes. ..
  22. Clinical Impact of Quinolone-Resistant E.coli carriage
    Ebbing Lautenbach; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  23. ENDOGENOUSLY REGULATED IMMUNOMODULATION
    Robert Munford; Fiscal Year: 2003
    ..abstract_text> ..
  24. INTERACTIONS OF ENDOTOXIN WITH PLASMA AND CELLS
    Robert Munford; Fiscal Year: 2007
    ..abstract_text> ..
  25. Novel Application of Infection Control Strategies to Limit Transmission of ESBL'S
    Ebbing Lautenbach; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  26. Quinolone resistant E coli in long term care facilities
    Ebbing Lautenbach; Fiscal Year: 2009
    ..abstract_text> ..
  27. Susceptibility Testing, Treatment Choices, and Outcomes of MDR-GNB Infections
    Lisa Saiman; Fiscal Year: 2009
    ..Carefully conducted observational studies and clinically relevant in vitro antimicrobial susceptibility testing, hold the greatest promise to improve the treatment of patients infected with mutidrug-resistant organisms. ..
  28. QUINOLONE RESISTANCE IN NOSOCOMIAL URINARY INFECTIONS
    Ebbing Lautenbach; Fiscal Year: 2004
    ....
  29. Regulatory Networks of Helicobacter pylori
    D Scott Merrell; Fiscal Year: 2011
    ..Our studies will help to shed light on genes involved in the process of surviving in the human body and should provide novel targets for vaccine and therapeutic design. ..
  30. Quantitative PCR for the Detection of Fungal Infections
    David Fredricks; Fiscal Year: 2008
    ..Hypothesis: Fungal 18S rDNA qPCR employing a broad range fungal probe, or a system of multiple specific probes, will be useful for detecting emerging fungal pathogens in the transplant setting. [unreadable] [unreadable]..
  31. H. hepaticus: the pathogenesis of IBD
    David Schauer; Fiscal Year: 2007
    ..It is hoped that these studies will lead to the development of new strategies for the treatment and the prevention of IBD. ..
  32. Incidence & Outcomes of SSI After Breast Cancer Surgery
    Margaret Olsen; Fiscal Year: 2008
    ....
  33. ADJUVANT EFFECTS OF ALPHA GALACTOSYLCERAMIDES
    Albert Bendelac; Fiscal Year: 2004
    ....
  34. Legionella pneumophila developmental cycle & virulence
    PAUL STOKES HOFFMAN; Fiscal Year: 2011
    ..These studies should also provide insights relevant to other opportunistic environmental pathogens including oxiella, Burkholderia and species of Mycobacterium. ..
  35. Environmental Effects on Lung Function in Cystic Fibrosis Patients
    Christopher Goss; Fiscal Year: 2008
    ..Our proposal will also enhance our understanding of lung growth in CF and represents the initial phase of a program to understand environmental effects on CF lung disease. [unreadable] [unreadable] [unreadable]..
  36. Type II secretion system of P. aeruginosa in acute lung infection
    Reuben Ramphal; Fiscal Year: 2010
    ..We wish to examine which of the many known toxins are involved in death and to explore new methods to block secretion of the toxins that may eventually be useful for therapy. ..
  37. Host variability in innate inflammatory responses
    Mark Wurfel; Fiscal Year: 2007
    ..abstract_text> ..
  38. Glutamine's role in cardioprotection from cardiac bypass
    Paul Wischmeyer; Fiscal Year: 2007
    ..Data will be collected on cardiac function (cardiac output), occurrence of arrhythmias, need for vasopressor therapy, length of post-operative ventilation, ICU stay; and survival trends. ..
  39. OmpR and acid regulation of Escherichia coli fim genes
    WILLIAM SCHWAN; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  40. Genetic epidemiology of TLR4 alleles and bacteremia
    Jason Chien; Fiscal Year: 2006
    ..Ultimately, this cohort of patients will be developed in anticipation of future genetic discoveries in the complicated pathway of pathogen recognition and host inflammatory response. ..
  41. Oral Pathogens: Polymicrobial Virulence Interactions
    KESAVALU LAKSHMYYA; Fiscal Year: 2006
    ..Consequently, the host response to these chronic infections must be considered as critical to general health. ..
  42. Study design importance in analyzing emerging pathogens
    Anthony Harris; Fiscal Year: 2005
    ..The second aim will be done by combining epidemiological relatedness and molecular relatedness through pulse-field gel electrophoresis of ESBL cultures to quantify the importance of patient to patient transmission. ..
  43. MOLECULAR PATHOLOGY OF LPS-INDUCED INJURY
    Richard Ulevitch; Fiscal Year: 2004
    ..The results of these studies, if successfully accomplished, may lead to the development of new strategies to control the innate immune responses in bacterial infection. ..
  44. SALMONELLA TYPE 3 SECRETION SYSTEM FOR ANTIGEN DELIVERY
    JORGE GALAN; Fiscal Year: 2004
    ..This will significantly broaden the utility of avirulent strains of Salmonella as platforms for the development of polyvalent vaccines. ..
  45. 0157:H7 INTIMIN AND STX--PATHOGENESIS IN A MOUSE MODEL
    David Schauer; Fiscal Year: 2003
    ..It should also lead to the development of a mouse model for studies of O157:H7 pathogenesis and for testing preventive and therapeutic approaches directed against this important foodborne illness. ..
  46. GROUP SEQUENTIAL METHODS FOR LONGITUDINAL DATA
    Scott Emerson; Fiscal Year: 2003
    ..abstract_text> ..
  47. PEDIATRIC ONCOLOGY GROUP STUDIES
    Thomas McLean; Fiscal Year: 2002
    ....
  48. Hospital and Community Acquired Acute Renal Failure
    Glenn Chertow; Fiscal Year: 2006
    ..This study will efficiently inform the Nephrology community by providing a foundation of fundamental information (ARF definitions, incidence, consequences and costs) upon which a clinical trials network can be built. ..
  49. Innate Immunity to Francisella tularensis
    MICHAEL PARMELY; Fiscal Year: 2006
    ....
  50. A Novel Vaccine Targeting HIV gp41 Sequences
    David Gardiner; Fiscal Year: 2007
    ..If successful, this design could serve as the foundation for a broadly applicable HIV vaccine. ..
  51. Prevention of Catheter-Associated Blood Stream Infections
    David Warren; Fiscal Year: 2007
    ..I will build on the experience outlined in this proposal to establish myself an independent investigator in healthcare epidemiology, studying nosocomial infections and developing interventions to prevent them. [unreadable] [unreadable]..
  52. Plasmid-Mediated Quinolone Resistance
    George Jacoby; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  53. Proline uptake in staphylococcus aureus pathogenesis
    WILLIAM SCHWAN; Fiscal Year: 2002
    ..The results of this study will help us understand the role of proline transport in S. aureus infections. ..
  54. Extracellular Matrix Protein in Innate Immunity
    You Wen He; Fiscal Year: 2007
    ..Results from this proposal will provide novel insights on the mechanisms of the innate immune response and may have implication for clinical treatment of septic shock and other microbe caused diseases. [unreadable] [unreadable]..
  55. ANTIRETROVIRAL PHARMACOLOGY IN THE GENITAL TRACT
    Angela Kashuba; Fiscal Year: 2007
    ..abstract_text> ..
  56. Regulation of CD1d by the Invariant Chain
    Albert Bendelac; Fiscal Year: 2006
    ..2) genetically dissect the Ii associated MZB phenotype by crossing Ii deficient mice to mice lacking Ii partners such as CD1d, H-2M and IA, and to BCR transgenic mice expressing MZB-included or excluded specificities. ..
  57. Effect of Glutamine on HSP-70 Expression in ICU patients
    Paul Wischmeyer; Fiscal Year: 2007
    ..The potential for such an agent to reduce morbidity/mortality in surgical and critical illness is significant. [unreadable] [unreadable]..
  58. BACTERIAL MEMBRANE PROTEINS IN GRAM-NEGATIVE SEPSIS
    H Warren; Fiscal Year: 2008
    ..The experiments are designed to evaluate the importance that physiologically relevant forms of MLP and PAL play in the pathophysiology of sepsis during infection. ..
  59. n-3 Fatty Acid & Host Responses to Oral Infection
    KESAVALU LAKSHMYYA; Fiscal Year: 2003
    ..Positive findings could enable improved dietary strategies as adjuncts in the prevention of periodontal disease. ..
  60. NEUTROPHILS AND BACTERIAL PHOSPHOLIPID DEGRADATION
    Jerrold Weiss; Fiscal Year: 2002
    ....
  61. Oral Commensal Bacterial Modulation of the Periodontal Innate Host Response
    RICHARD PETERS DARVEAU; Fiscal Year: 2010
    ....
  62. PSEUDOMONAS AERUGINOSA FLAGELLAR BIOGENESIS PATHWAY
    Reuben Ramphal; Fiscal Year: 2007
    ..abstract_text> ..
  63. Pattern Recognition Molecule Mindin As Adjuvant
    You Wen He; Fiscal Year: 2007
    ..Third, Mindin fused DNA plasmids will be examined for their efficacy in protecting influenza virus infection. [unreadable] [unreadable]..
  64. Polymyxin-resistant Pseudomonas in CF Lung Infection
    Samuel M Moskowitz; Fiscal Year: 2010
    ..An interdisciplinary study of polymyxin resistant Pseudomonas from patients with cystic fibrosis is proposed to pinpoint the bacterial genes responsible for this resistance, so that management strategies may be devised to overcome it. ..