pneumococcal meningitis

Summary

Summary: An acute purulent infection of the meninges and subarachnoid space caused by Streptococcus pneumoniae, most prevalent in children and adults over the age of 60. This illness may be associated with OTITIS MEDIA; MASTOIDITIS; SINUSITIS; RESPIRATORY TRACT INFECTIONS; sickle cell disease (ANEMIA, SICKLE CELL); skull fractures; and other disorders. Clinical manifestations include FEVER; HEADACHE; neck stiffness; and somnolence followed by SEIZURES; focal neurologic deficits (notably DEAFNESS); and COMA. (From Miller et al., Merritt's Textbook of Neurology, 9th ed, p111)

Top Publications

  1. pmc Bacteremia causes hippocampal apoptosis in experimental pneumococcal meningitis
    Christian Østergaard
    Department of Clinical Microbiology, Copenhagen University Hospital Herlev, Herlev, Denmark
    BMC Infect Dis 10:1. 2010
  2. pmc Apoptosis is essential for neutrophil functional shutdown and determines tissue damage in experimental pneumococcal meningitis
    Uwe Koedel
    Department of Neurology, Clinic of the University of Munich, Munich, Germany
    PLoS Pathog 5:e1000461. 2009
  3. ncbi Inhibition of matrix metalloproteinases and tumour necrosis factor alpha converting enzyme as adjuvant therapy in pneumococcal meningitis
    S L Leib
    Institute for Infectious Diseases, University of Bern, Berne, Switzerland
    Brain 124:1734-42. 2001
  4. ncbi Epidemiological and molecular characteristics of a highly lethal pneumococcal meningitis epidemic in Burkina Faso
    Seydou Yaro
    Centre Muraz, Bobo Dioulasso, Burkina Faso
    Clin Infect Dis 43:693-700. 2006
  5. ncbi Phage lytic enzyme Cpl-1 for antibacterial therapy in experimental pneumococcal meningitis
    Denis Grandgirard
    Institute for Infectious Diseases, University of Bern, Switzerland
    J Infect Dis 197:1519-22. 2008
  6. ncbi An infant mouse model of brain damage in pneumococcal meningitis
    Denis Grandgirard
    Institute for Infectious Diseases, University of Bern, Friedbuhlstrasse 51, 3010, Bern, Switzerland
    Acta Neuropathol 114:609-17. 2007
  7. ncbi Changing epidemiology of pneumococcal meningitis after the introduction of pneumococcal conjugate vaccine in the United States
    Chiaojung Jillian Tsai
    Department of Preventive Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37212, USA
    Clin Infect Dis 46:1664-72. 2008
  8. ncbi Nationwide implementation of adjunctive dexamethasone therapy for pneumococcal meningitis
    M C Brouwer
    Department of Neurology, Center of Infection and Immunity Amsterdam CINIMA, Academic Medical Center, Amsterdam, The Netherlands
    Neurology 75:1533-9. 2010
  9. pmc Twenty year surveillance of invasive pneumococcal disease in Nottingham: serogroups responsible and implications for immunisation
    P Ispahani
    Department of Medical Microbiology, Queen s Medical Centre, University Hospital, Nottingham NG7 2UH, UK
    Arch Dis Child 89:757-62. 2004
  10. pmc Identification of serotype in culture negative pneumococcal meningitis using sequential multiplex PCR: implication for surveillance and vaccine design
    Samir K Saha
    Department of Microbiology, Bangladesh Institute of Child Health, Dhaka Shishu Children Hospital, Dhaka, Bangladesh
    PLoS ONE 3:e3576. 2008

Research Grants

  1. Transmission of Drug-Resistant S. pneumoniae in Brazil
    JOICE PEDREIRA; Fiscal Year: 2009
  2. Lethal synergism between influenza and pneumococcus
    Jonathan McCullers; Fiscal Year: 2003
  3. Study of risk factors of tick-borne encephalitis in Poland
    Pawel Stefanoff; Fiscal Year: 2009
  4. Synergism Between Influenza Virus and Pneumococcus
    Jonathan McCullers; Fiscal Year: 2009
  5. Appropriate Pneumococcal Vaccination in Infants in Fiji
    Fiona Russell; Fiscal Year: 2007
  6. Optimal Strategies for PID Prevention and Management
    Kenneth Smith; Fiscal Year: 2007
  7. CONTROL OF AUTOLYSIS IN PNEUMOCOCCI
    Elaine Tuomanen; Fiscal Year: 2006
  8. 3rd Orthomyxoviruses Research Conference
    Jonathan McCullers; Fiscal Year: 2005
  9. Gene Discovery for Pneumococcal Otitis Media
    Melinda Pettigrew; Fiscal Year: 2005
  10. Influenza-pneumococcal synergism: role of neuraminidase
    Jonathan McCullers; Fiscal Year: 2004

Detail Information

Publications289 found, 100 shown here

  1. pmc Bacteremia causes hippocampal apoptosis in experimental pneumococcal meningitis
    Christian Østergaard
    Department of Clinical Microbiology, Copenhagen University Hospital Herlev, Herlev, Denmark
    BMC Infect Dis 10:1. 2010
    ..systemic complications both play important roles in brain pathophysiological alterations and the outcome of pneumococcal meningitis. Their individual contributions to the development of brain damage, however, still remain to be defined.
  2. pmc Apoptosis is essential for neutrophil functional shutdown and determines tissue damage in experimental pneumococcal meningitis
    Uwe Koedel
    Department of Neurology, Clinic of the University of Munich, Munich, Germany
    PLoS Pathog 5:e1000461. 2009
    ..Neutrophils show pro-inflammatory activity and may contribute to tissue damage. In pneumococcal meningitis, neuronal damage despite adequate chemotherapy is a frequent clinical finding...
  3. ncbi Inhibition of matrix metalloproteinases and tumour necrosis factor alpha converting enzyme as adjuvant therapy in pneumococcal meningitis
    S L Leib
    Institute for Infectious Diseases, University of Bern, Berne, Switzerland
    Brain 124:1734-42. 2001
    ..In the present time-course studies of pneumococcal meningitis in infant rats, MMP-8 and -9 were 100- to 1000-fold transcriptionally upregulated, both in CSF cells and ..
  4. ncbi Epidemiological and molecular characteristics of a highly lethal pneumococcal meningitis epidemic in Burkina Faso
    Seydou Yaro
    Centre Muraz, Bobo Dioulasso, Burkina Faso
    Clin Infect Dis 43:693-700. 2006
    ..Public health and clinical strategies for meningitis epidemics in sub-Saharan Africa usually assume that Neisseria meningitidis infection causes most disease...
  5. ncbi Phage lytic enzyme Cpl-1 for antibacterial therapy in experimental pneumococcal meningitis
    Denis Grandgirard
    Institute for Infectious Diseases, University of Bern, Switzerland
    J Infect Dis 197:1519-22. 2008
    ..pneumoniae, was evaluated for antimicrobial therapy in experimental pneumococcal meningitis using infant Wistar rats...
  6. ncbi An infant mouse model of brain damage in pneumococcal meningitis
    Denis Grandgirard
    Institute for Infectious Diseases, University of Bern, Friedbuhlstrasse 51, 3010, Bern, Switzerland
    Acta Neuropathol 114:609-17. 2007
    ..Different animal models of pneumococcal meningitis have been developed to study the pathogenesis of the disease...
  7. ncbi Changing epidemiology of pneumococcal meningitis after the introduction of pneumococcal conjugate vaccine in the United States
    Chiaojung Jillian Tsai
    Department of Preventive Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37212, USA
    Clin Infect Dis 46:1664-72. 2008
    ..due to invasive pneumococcal disease decreased after routine vaccination of young children with a 7-valent pneumococcal conjugate vaccine (PCV7) began in 2000, information on the trends in pneumococcal meningitis is limited.
  8. ncbi Nationwide implementation of adjunctive dexamethasone therapy for pneumococcal meningitis
    M C Brouwer
    Department of Neurology, Center of Infection and Immunity Amsterdam CINIMA, Academic Medical Center, Amsterdam, The Netherlands
    Neurology 75:1533-9. 2010
    In this nationwide prospective cohort study, we evaluated the implementation of adjunctive dexamethasone therapy in Dutch adults with pneumococcal meningitis.
  9. pmc Twenty year surveillance of invasive pneumococcal disease in Nottingham: serogroups responsible and implications for immunisation
    P Ispahani
    Department of Medical Microbiology, Queen s Medical Centre, University Hospital, Nottingham NG7 2UH, UK
    Arch Dis Child 89:757-62. 2004
    ..To determine the major serogroups of Streptococcus pneumoniae responsible for invasive disease and the potential coverage by the new pneumococcal conjugate vaccines...
  10. pmc Identification of serotype in culture negative pneumococcal meningitis using sequential multiplex PCR: implication for surveillance and vaccine design
    Samir K Saha
    Department of Microbiology, Bangladesh Institute of Child Health, Dhaka Shishu Children Hospital, Dhaka, Bangladesh
    PLoS ONE 3:e3576. 2008
    ..Furthermore, PCR has not been used to determine serotype distribution in culture-negative meningitis cases...
  11. ncbi Pneumococcal meningitis in adults: new approaches to management and prevention
    Martijn Weisfelt
    Department of Neurology, Centre of Infection and Immunity Amsterdam CINIMA, Academic Medical Centre, Amsterdam, Netherland
    Lancet Neurol 5:332-42. 2006
    ..eradication of meningitis due to Haemophilus influenzae type B by vaccination in the developed world, pneumococcal meningitis has become the leading cause of bacterial meningitis beyond the neonatal period...
  12. ncbi MyD88 is required for mounting a robust host immune response to Streptococcus pneumoniae in the CNS
    Uwe Koedel
    Department of Neurology, Klinikum Grosshadern, Ludwig Maximilians University, Marchioninistrasse 15, D 81377 Munich, Germany
    Brain 127:1437-45. 2004
    ..In order to characterize the role of MyD88 in pneumococcal meningitis we used gene-targeted mice lacking functional MyD88 expression...
  13. ncbi Brain-derived neurotrophic factor protects against multiple forms of brain injury in bacterial meningitis
    Yoeng Delphine Bifrare
    Institute for Infectious Diseases, University of Bern, 3010 Bern, Switzerland
    J Infect Dis 191:40-5. 2005
    ..The mechanisms of neuroprotection suggest that BDNF may be beneficial in bacterial meningitis...
  14. ncbi Pneumococcal meningitis in the era of pneumococcal conjugate vaccine implementation
    E Bingen
    Service de Microbiologie, Hopital Robert Debre, 48 Bvd Serurier, F75019 Paris, France
    Eur J Clin Microbiol Infect Dis 27:191-9. 2008
    ..Diseases Group set up an active surveillance network to analyze the clinical and biological features of pneumococcal meningitis and the impact of the seven-valent pneumococcal conjugate vaccine (PCV7)...
  15. ncbi Depressive-like-behavior and proinflamatory interleukine levels in the brain of rats submitted to pneumococcal meningitis
    Tatiana Barichello
    Laboratory of Experimental Microbiology and National Institute for Translational Medicine INCT TM, Postgraduate Program in Health Sciences, Health Sciences Unit, University of Southern Santa Catarina, 88806 000 Criciuma, SC, Brazil
    Brain Res Bull 82:243-6. 2010
    ..test and verified the levels of the TNF-alpha, IL-1beta, IL-6 and CINC-1 in the brain of rats induced to pneumococcal meningitis. In the forced swimming test we observed a significant increase in the immobility time in the meningitis ..
  16. ncbi Decline in pneumococcal meningitis in Spain after introduction of the heptavalent pneumococcal conjugate vaccine
    Juan Casado-Flores
    Hospital Nino Jesus, Madrid, Spain
    Pediatr Infect Dis J 27:1020-2. 2008
    All patients < or =14 years old with a diagnosis of pneumococcal meningitis (n = 160) were included (2001, 2004-2006). Incidence per 100,000 child <5 years old varied from 6.14 in 2001 to 2.83 in 2006 (54% of reduction, P < 0...
  17. pmc Decline in pneumococcal meningitis after the introduction of the heptavalent-pneumococcal conjugate vaccine in northern France
    F Dubos
    Paediatric Emergency and Infectious Diseases Unit, Department of Paediatrics, Jeanne de Flandre Hospital and Lille 2 University, Lille, France
    Arch Dis Child 92:1009-12. 2007
    The impact of the heptavalent-pneumococcal conjugate vaccine on the incidence of pneumococcal meningitis in Europe has not yet been assessed.
  18. ncbi Invasive pneumococcal disease among adults: associations among serotypes, disease characteristics, and outcome
    Angelique G S C Jansen
    Department of Pediatric Immunology and Infectious Diseases, Wilhelmina Children s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
    Clin Infect Dis 49:e23-9. 2009
    ..The Streptococcus pneumoniae polysaccharide capsule may be related to invasive pneumococcal disease (IPD) course...
  19. pmc Treatment with a monocolonal antibody to IL-8 attenuates the pleocytosis in experimental pneumococcal meningitis in rabbits when given intravenously, but not intracisternally
    C Ostergaard
    Department of Research and Development, Statens Serum Institut, Copenhagen, Denmark
    Clin Exp Immunol 122:207-11. 2000
    ..IL)-8 as mediator in the recruitment of leucocytes into the CSF was investigated during experimental pneumococcal meningitis. Rabbits were inoculated intracisternally with approximately 10(6) CFU Streptococcus pneumoniae, and ..
  20. ncbi Toll-like receptor 2 participates in mediation of immune response in experimental pneumococcal meningitis
    Uwe Koedel
    Department of Neurology, Klinikum Grosshadern, Ludwig Maximilians University, Munich, Germany
    J Immunol 170:438-44. 2003
    ..The present study characterized the role of TLR2 in the host immune response and clinical course of pneumococcal meningitis. Pneumococcal infection of mice caused a significant increase in brain TLR2 mRNA expression at both 4 and ..
  21. ncbi Proteomic analysis of cerebrospinal fluid in pneumococcal meningitis reveals potential biomarkers associated with survival
    Upali R Goonetilleke
    Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, United Kingdom
    J Infect Dis 202:542-50. 2010
    Patients with pneumococcal meningitis often die or have severe neurological damage despite optimal antibiotic therapy. New or improved therapy is required...
  22. ncbi Otoprotective effects of dexamethasone in the management of pneumococcal meningitis: an animal study
    Harold H Kim
    Wilson Ear Clinic, Portland, Oregon 97209, USA
    Laryngoscope 117:1209-15. 2007
    To determine whether treating pneumococcal meningitis with a combined antibiotic and steroid regime will prevent cochlear damage, a common pneumococcal meningitis side effect.
  23. pmc Daptomycin in experimental murine pneumococcal meningitis
    Barry B Mook-Kanamori
    Division of Infectious Disease, Department of Internal Medicine, College of Medicine, Mayo Clinic, Rochester, MN, USA
    BMC Infect Dis 9:50. 2009
    Daptomycin, a lipopeptide antibiotic, could be an alternative to vancomycin for treatment of pneumococcal meningitis. We determined the activity of daptomycin versus vancomycin, with dexamethasone as an adjuvant, in a murine model of ..
  24. ncbi Caspase-3 mediates hippocampal apoptosis in pneumococcal meningitis
    Christian Gianinazzi
    Institute for Infectious Diseases, University of Bern, Friedbuhlstrasse 51, 3010 Bern, Switzerland
    Acta Neuropathol 105:499-507. 2003
    ..the time course and the role of caspase-3 in neuronal apoptosis was assessed in an infant rat model of pneumococcal meningitis. During clinically asymptotic meningitis (0-12 h after infection), only minor apoptotic damage to the ..
  25. pmc Reduction of astrogliosis by early treatment of pneumococcal meningitis measured by simultaneous imaging, in vivo, of the pathogen and host response
    Jagath L Kadurugamuwa
    Clorox Services Company, 7200 Johnson Dr, Pleasanton, CA 94588, USA
    Infect Immun 73:7836-43. 2005
    We developed a method for simultaneous in vivo biophotonic monitoring of pneumococcal meningitis and the accompanying neuronal injury in live transgenic mice...
  26. ncbi Role of Caspase-1 in experimental pneumococcal meningitis: Evidence from pharmacologic Caspase inhibition and Caspase-1-deficient mice
    Uwe Koedel
    Department of Neurology, Klinikum Grosshadern, Ludwig Maximilians University, Munich, Germany
    Ann Neurol 51:319-29. 2002
    ..Interleukin-1beta is implicated as a mediator of pneumococcal meningitis, both in experimental models and in humans...
  27. ncbi Pathogenesis and pathophysiology of pneumococcal meningitis
    Uwe Koedel
    UK and H WP are at the Department of Neurology, Klinikum Grosshadern, Ludwig Maximilians University, Munich, Germany
    Lancet Infect Dis 2:721-36. 2002
    ..Apart from dexamethasone, these treatment strategies hold major promise for the adjunctive therapy of acute bacterial meningitis in clinical practice...
  28. pmc Tracking the transcriptional host response from the acute to the regenerative phase of experimental pneumococcal meningitis
    Matthias Wittwer
    Institute for Infectious Diseases, University of Bern, Friedbuehlstrasse 51, CH 3010 Bern, Switzerland
    BMC Infect Dis 10:176. 2010
    Despite the availability of effective antibiotic therapies, pneumococcal meningitis (PM) has a case fatality rate of up to 30% and causes neurological sequelae in up to half of the surviving patients...
  29. pmc Pneumococcal carriage results in ganglioside-mediated olfactory tissue infection
    Frederik W van Ginkel
    Department of Microbiology, Immunobiology Vaccine Center, University of Alabama at Birmingham, Birmingham, AL 35294 2170, USA
    Proc Natl Acad Sci U S A 100:14363-7. 2003
    ..These findings, confirmed by PCR and immunohistochemistry, support a GLS-mediated process of infection and are consistent with pneumococci reaching the brain through retrograde axonal transport...
  30. ncbi Discrepancies between brain CT imaging and severely raised intracranial pressure proven by ventriculostomy in adults with pneumococcal meningitis
    Frank Winkler
    Department of Neurology, Klinikum Grosshadern, Ludwig Maximilians University, Marchioninistr 15, 81377 Munich, Germany
    J Neurol 249:1292-7. 2002
    ..The aim of this report is to draw attention to the possibility of a discrepancy between CT findings and ICP values in some patients with pneumococcal meningitis.
  31. ncbi Detrimental role of delayed antibiotic administration and penicillin-nonsusceptible strains in adult intensive care unit patients with pneumococcal meningitis: the PNEUMOREA prospective multicenter study
    Marc Auburtin
    From the Service de Réanimation Médicale et des Maladies Infectieuses, Hopital Bichat Claude Bernard, AP HP, Paris, France
    Crit Care Med 34:2758-65. 2006
    To identify factors associated with mortality and morbidity among adults admitted to intensive care units (ICUs) for pneumococcal meningitis, particularly the impact of delayed antibiotic administration.
  32. ncbi Effects of clinically used antioxidants in experimental pneumococcal meningitis
    M Auer
    Institute for Medical Microbiology, Infectious Diseases Resaerch Laboratory, University of Bern, Bern, Switzerland
    J Infect Dis 182:347-50. 2000
    ..The present study evaluated whether these antioxidants are beneficial in a model of pneumococcal meningitis. Eleven-day-old rats were infected intracisternally with Streptococcus pneumoniae and randomized to ..
  33. ncbi Effect of pneumococcal conjugate vaccine on pneumococcal meningitis
    Heather E Hsu
    University of Pittsburgh, Pittsburgh, PA 15261, USA
    N Engl J Med 360:244-56. 2009
    Invasive pneumococcal disease declined among children and adults after the introduction of the pediatric heptavalent pneumococcal conjugate vaccine (PCV7) in 2000, but its effect on pneumococcal meningitis is unclear.
  34. pmc Adjuvant TACE inhibitor treatment improves the outcome of TLR2-/- mice with experimental pneumococcal meningitis
    Hakim Echchannaoui
    Division of Infectious Diseases, Department of Research, University Hospitals, Basel, Switzerland
    BMC Infect Dis 7:25. 2007
    ..Toll-like receptor 2 (TLR2) contributes to host response in pneumococcal meningitis by enhancing bacterial clearing and downmodulating inflammation...
  35. pmc Serotyping pneumococcal meningitis cases in the African meningitis belt by use of multiplex PCR with cerebrospinal fluid
    Berthe Marie Njanpop Lafourcade
    Agence de Medecine Preventive, at the Institut Pasteur, 25 28 Rue du Dr Roux, 75724 Paris Cedex 15, France
    J Clin Microbiol 48:612-4. 2010
    We reformulated a multiplex PCR algorithm for serotyping of pneumococcal meningitis directly on cerebrospinal fluid (CSF). Compared to established methods on isolates, CSF-based PCR had at least 80% sensitivity and 100% specificity...
  36. ncbi Role of glial cells in the functional expression of LL-37/rat cathelin-related antimicrobial peptide in meningitis
    Lars Ove Brandenburg
    Department of Anatomy and Cell Biology, RWTH Aachen University, Aachen, Germany
    J Neuropathol Exp Neurol 67:1041-54. 2008
    ..Together, these results suggest that cathelicidins produced by glia and other cells play an important part in the innate immune response against pathogens in central nervous system bacterial infections...
  37. pmc Method for inducing experimental pneumococcal meningitis in outbred mice
    Damiana Chiavolini
    Dipartimento di Biologia Molecolare, Laboratorio di Microbiologia Molecolare e Biotecnologia, Policlinico Le Scotte, Universita di Siena, Viale Bracci, 53100 Siena, Italy
    BMC Microbiol 4:36. 2004
    Streptococcus pneumoniae is the leading cause of bacterial meningitis. Pneumococcal meningitis is associated with the highest mortality among bacterial meningitis and it may also lead to neurological sequelae despite the use of ..
  38. ncbi Surveillance for Streptococcus pneumoniae meningitis in children aged <5 years: implications for immunization in Uganda
    Annet Kisakye
    Uganda National Expanded Programme on Immunization, Ministry of Health, Kampala, Uganda
    Clin Infect Dis 48:S153-61. 2009
    ..Minimum pneumococcal meningitis incidence estimates were calculated for a portion of the Kampala district and all of the Gulu district, ..
  39. ncbi Decompressive craniectomy in a case of intractable intracranial hypertension due to pneumococcal meningitis
    A Perin
    Neurosurgical Unit, Treviso Hospital, University of Padova, Treviso, Italy
    Acta Neurochir (Wien) 150:837-42; discussion 842. 2008
    ..Conclusive data on the impact of DC on the final outcome of such patients are not available yet...
  40. ncbi Incidence, seasonality, age distribution, and mortality of pneumococcal meningitis in Burkina Faso and Togo
    Yves Traore
    Universite de Ouagadougou, Ouagadougou, Burkina Faso
    Clin Infect Dis 48:S181-9. 2009
    ..In Burkina Faso, the annual incidence rate of pneumococcal meningitis was 14 cases per 100,000 persons, with annual incidence rates of 77, 33, 10, and 11 cases per 100,000 ..
  41. ncbi Pneumococcal meningitis induces apoptosis in recently postmitotic immature neurons in the dentate gyrus of neonatal rats
    D Grandgirard
    Institute for Infectious Diseases, University of Bern, Bern, Switzerland
    Dev Neurosci 29:134-42. 2007
    ..Previous studies have documented that in neonatal rats with experimental pneumococcal meningitis, cells in the subgranular layer of the dentate gyrus undergo apoptosis...
  42. pmc Antibiotic susceptibility in relation to penicillin-binding protein genes and serotype distribution of Streptococcus pneumoniae strains responsible for meningitis in Japan, 1999 to 2002
    Kimiko Ubukata
    Kitasato Institute for Life Sciences and Graduate School of Infection Control Sciences, Kitasato University, 5 9 1 Shirokane, Minato ku, Japan
    Antimicrob Agents Chemother 48:1488-94. 2004
    ..9 and 56.0%, respectively). These findings suggest the need for early introduction of pneumococcal conjugate vaccines and continuous bacteriological surveillance for meningitis...
  43. ncbi Increased neurogenesis after experimental Streptococcus pneumoniae meningitis
    Joachim Gerber
    Department of Neurology, Georg August University, Gottingen, Germany
    J Neurosci Res 73:441-6. 2003
    ..This suggests that endogenous repair mechanisms may limit consequences of neuronal destruction after meningitis...
  44. ncbi Can we prevent cochlear implant recipients from developing pneumococcal meningitis?
    Benjamin P C Wei
    The Bionic Ear Institute, Melbourne East, Victoria, Australia
    Clin Infect Dis 46:e1-7. 2008
    ..However, pneumococcal meningitis in implant recipients has received high profile public attention as a result of the US Food and Drug ..
  45. ncbi Impact of bacteremia on the pathogenesis of experimental pneumococcal meningitis
    Christian T Brandt
    National Center for Antimicrobials and Infection Control, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    J Infect Dis 197:235-44. 2008
    Bacteremia plays a major role in the outcome of pneumococcal meningitis. This experimental study investigated how bacteremia influences the pathophysiologic profile of the brain.
  46. ncbi Experimental study of meropenem in the therapy of cephalosporin-susceptible and -resistant pneumococcal meningitis
    E Force
    Laboratory of Experimental Infection, Infectious Diseases Service, IDIBELL, Hospital Universitari de Bellvitge, Feixa Llarga s n, 08907 L Hospitalet de Llobregat, Barcelona, Spain
    Eur J Clin Microbiol Infect Dis 27:685-90. 2008
    ..We believe that guinea pig should be considered the best choice among laboratory animal species when assessing meropenem efficacy...
  47. pmc Gene expression in cortex and hippocampus during acute pneumococcal meningitis
    Roney S Coimbra
    Institute for Infectious Diseases, University of Bern, Friedbuhlstrasse 51, CH 3010, Bern, Switzerland
    BMC Biol 4:15. 2006
    b>Pneumococcal meningitis is associated with high mortality (approximately 30%) and morbidity. Up to 50% of survivors are affected by neurological sequelae due to a wide spectrum of brain injury mainly affecting the cortex and hippocampus...
  48. pmc A population based study of the impact of corticosteroid therapy and delayed diagnosis on the outcome of childhood pneumococcal meningitis
    P B McIntyre
    National Centre for Immunisation Research and Surveillance of Vaccine Preventable Diseases, The Children s Hospital at Westmead and University of Sydney, NSW, Australia
    Arch Dis Child 90:391-6. 2005
    Despite an extensive literature, the impact of both adjunctive steroid therapy and delayed diagnosis on the outcome of childhood pneumococcal meningitis is controversial.
  49. ncbi Inhibition of the kynurenine-NAD+ pathway leads to energy failure and exacerbates apoptosis in pneumococcal meningitis
    Caroline L Bellac
    Institute for Infectious Diseases, University of Bern, Bern, Switzerland
    J Neuropathol Exp Neurol 69:1096-104. 2010
    b>Pneumococcal meningitis causes neurological sequelae, including learning and memory deficits in up to half of the survivors...
  50. ncbi Pneumococcal meningitis causes accumulation of neurotoxic kynurenine metabolites in brain regions prone to injury
    Caroline L Bellac
    Institute for Infectious Diseases, University of Bern, Friedbuehlstrasse 51, PO Box 61, CH 3010 Bern, Switzerland
    Neurobiol Dis 24:395-402. 2006
    b>Pneumococcal meningitis (PM) is characterized by an intense inflammatory host reaction that contributes to the development of cortical necrosis and hippocampal apoptosis...
  51. pmc Pneumococcal meningitis: development of a new animal model
    Benjamin P C Wei
    Bionic Ear Institute, Department of Otolaryngology, University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Victoria, Australia
    Otol Neurotol 27:844-54. 2006
    The rat is a suitable animal to establish a model for the study of pneumococcal meningitis postcochlear implantation.
  52. ncbi Pneumococcal meningitis during antiviral treatment with interferon and ribavirin in a splenectomized patient with chronic hepatitis C - do not miss vaccination before starting therapy
    J Hadem
    Department of Gastroenterology, Hepatology and Endocrinology, Medical School Hannover, Carl Neuberg Str 1, 30625 Hannover, Germany
    Z Gastroenterol 46:880-2. 2008
    We report on a 35-year-old man who developed pneumococcal meningitis while receiving antiviral therapy with interferon (consensus interferon, CIFN) and ribavirin for chronic hepatitis C...
  53. ncbi Blocking of leukocyte accumulation in the cerebrospinal fluid augments bacteremia and increases lethality in experimental pneumococcal meningitis
    Christian T Brandt
    National Center for Antimicrobials and Infection Control, Statens Serum Institut, Artillerivej 5, 2300 Copenhagen S, Denmark
    J Neuroimmunol 166:126-31. 2005
    ..the CSF, modulated by the leukocyte blocker fucoidin, affects the extent of brain damage and outcome in pneumococcal meningitis in rats treated with ceftriaxone from 28 h after infection...
  54. pmc Penicillin-resistant pneumococcal meningitis: high antibiotic exposure impedes new vaccine protection
    L Temime
    INSERM U444 Epidémiologie et Sciences de l Information, Paris, France
    Epidemiol Infect 133:493-501. 2005
    ..Our results suggest that antibiotic exposure reduction will remain of primary importance for the control of PRP meningitis despite wide scale use of pneumococcal conjugate vaccines...
  55. doi Vertebral osteomyelitis complicating pneumococcal meningitis
    M C Brouwer
    Academic Medical Center Department of Neurology, University of Amsterdam, P O Box 22700, 1100 DE Amsterdam, The Netherlands
    Neurology 71:612-3. 2008
  56. ncbi IL-1 receptor type 1 gene-deficient mice demonstrate an impaired host defense against pneumococcal meningitis
    Petra J G Zwijnenburg
    Department of Pediatrics, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    J Immunol 170:4724-30. 2003
    ..To determine the role of IL-1 in pneumococcal meningitis we induced meningitis by intranasal inoculation with 8 x 10(4) CFU of S...
  57. ncbi CD14 deficiency leads to increased MIP-2 production, CXCR2 expression, neutrophil transmigration, and early death in pneumococcal infection
    Hakim Echchannaoui
    Department of Research, University Hospital, Hebelstrasse 20, CH 4031 Basel, Switzerland
    J Leukoc Biol 78:705-15. 2005
    ..In conclusion, CD14 plays a protective role in pneumococcal meningitis by slowing PMN migration via MIP-2 and CXCR2 modulation.
  58. ncbi Linezolid as rescue therapy for pneumococcal meningitis
    Paula Ramirez
    Intensive Care Med 33:924-5. 2007
  59. ncbi Serotype 6B pneumococcal meningitis in an immunocompetent infant immunized with heptavalent pneumococcal conjugated vaccine
    Francois Angoulvant
    Clin Infect Dis 40:494-5. 2005
  60. pmc Attenuated cerebrospinal fluid leukocyte count and sepsis in adults with pneumococcal meningitis: a prospective cohort study
    Martijn Weisfelt
    Department of Neurology, Centre of Infection and Immunity Amsterdam CINIMA, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    BMC Infect Dis 6:149. 2006
    ..Whereas a low CSF WBC indicates the presence of sepsis with early meningitis in patients with meningococcal infections, the relation between CSF WBC and outcome in patients with pneumococcal meningitis is not understood.
  61. ncbi Inducible nitric oxide synthase mediates hippocampal caspase-3 activation in pneumococcal meningitis
    Johann Braun
    Department of Neurology, Charite University Medicine, Berlin, Germany
    Int J Neurosci 119:455-9. 2009
    ..synthase (iNOS)--is a major inflammatory mediator clearly upregulated in the cerebrospinal fluid during pneumococcal meningitis. However, its effects in bacterial meningitis are still controversial...
  62. pmc Streptococcus pneumoniae damages the ciliated ependyma of the brain during meningitis
    Robert A Hirst
    Department of Child Health, Robert Kilpatrick Clinical Sciences Building, University of Leicester, Leicestert Royal Infirmary, PO Box 65, Leicester LE2 7LX, U K
    Infect Immun 71:6095-100. 2003
    ..In conclusion, loss of ependymal cells and ciliary function exposes the underlying neuronal milieu to host and bacterial cytotoxins and this is likely to contribute to the neuropathology commonly observed in pneumococcal meningitis.
  63. ncbi Lack of endothelial nitric oxide synthase aggravates murine pneumococcal meningitis
    U Koedel
    Department of Neurology, Klinikum Grosshadern, Ludwig Maximilians University of Munich, Germany
    J Neuropathol Exp Neurol 60:1041-50. 2001
    ..eNOS depletion on the inflammatory host response, intracranial complications, and outcome in experimental pneumococcal meningitis. Leukocyte accumulation in the cerebrospinal fluid was more pronounced in infected eNOS-deficient mice ..
  64. ncbi Pneumococcal meningitis secondary to intra-sphenoidal encephalocoele
    Gillian M Sare
    Department of Neurology, Greater Manchester Neurosciences Centre, Manchester, UK
    Acta Neurochir (Wien) 151:103-4. 2009
    ..Initial endoscopic transsphenoidal repair was unsuccessful, necessitating a combined subtemporal and transsphenoidal approach to close the defect...
  65. ncbi Differential regulation of blood-brain barrier permeability in brain trauma and pneumococcal meningitis-role of Src kinases
    Robert Paul
    Department of Neurology, Klinikum Grosshadern, Ludwig Maximilians University, Marchioninistr 15, D 81377 Munich, Germany
    Exp Neurol 203:158-67. 2007
    ..cerebrospinal fluid (CSF) pleocytosis, brain edema formation, and bacterial outgrowth during experimental pneumococcal meningitis despite the increased cerebral expression of inflammatory chemokines, such as IL-6, CCL-9, CXCL-1, CXCL-2 ..
  66. ncbi Evaluation of a triple-drug combination for treatment of experimental multidrug-resistant pneumococcal meningitis
    Hyuck Lee
    Dong A University, Busan, South Korea
    Int J Antimicrob Agents 23:307-10. 2004
    To evaluate the therapeutic efficacy of ceftriaxone + vancomycin + rifampicin (CVR) in the treatment of pneumococcal meningitis caused by a multidrug-resistant strain, single-drug regimens (ceftriaxone 100 mg/kg, rifampicin 15 mg/kg, or ..
  67. pmc Interleukin-10 negatively regulates local cytokine and chemokine production but does not influence antibacterial host defense during murine pneumococcal meningitis
    Petra J G Zwijnenburg
    Department of Pediatrics, Vrije Universiteit Medical Center, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Infect Immun 71:2276-9. 2003
    To determine the role of endogenous interleukin-10 (IL-10) in local host defense during pneumococcal meningitis, the inflammatory responses of IL-10-gene-deficient and wild-type mice after the induction of meningitis were compared...
  68. ncbi S100B in the cerebrospinal fluid--a marker for glial damage in the rabbit model of pneumococcal meningitis
    H Schmidt
    University of Goettingen, Department of Neurology Department of Medical Psychology and Medical Sociology, Robert Koch Str 40, D 37099 Goettingen, Germany
    Neurosci Lett 475:104-7. 2010
    ..The rabbit model provides an important experimental setting for the evaluation of antibiotic agents against pneumococcal meningitis. One of the primary targets of this model is the study of neuronal and glial cell damage in bacterial ..
  69. ncbi Current concepts in the pathogenesis of meningitis caused by Streptococcus pneumoniae
    Damian N Meli
    Institute for Infectious Diseases, University of Berne, Berne, Switzerland
    Curr Opin Infect Dis 15:253-7. 2002
    ..It is the hope that a more refined molecular understanding of the pathogenesis of brain damage during bacterial meningitis will lead to new adjunctive therapies...
  70. ncbi Capture-recapture analysis and pneumococcal meningitis estimates in England
    Ardiana Gjini
    Department of Pathology and Microbiology, School of Medical Sciences, University of Bristol, Bristol, United Kingdom
    Emerg Infect Dis 10:87-93. 2004
    To improve estimates of disease incidence and deaths from pneumococcal meningitis among adults in England, we performed a capture-recapture analysis for 1996 through 1999...
  71. ncbi [Serotype 19F pneumococcal meningitis in an imunocompetent infant immunized with heptavalent pneumococcal conjugated vaccine Prevenar]
    A Isapof
    Service de Pediatrie, CHI de Créteil, 40, avenue de Verdun, 94000 Creteil, France
    Arch Pediatr 16:1133-6. 2009
    Seven cases of pneumococcal meningitis caused by serotypes covered by the available vaccine occurred in France in vaccinated children, 4 of which were caused by serotype 19F.
  72. ncbi Pneumococcal meningitis in the rat: evaluation of peroxynitrite scavengers for adjunctive therapy
    S Kastenbauer
    Department of Neurology, Klinikum Grosshadern, Ludwig Maximilians University, Marchioninistr 15, 81377 Munich, Germany
    Eur J Pharmacol 449:177-81. 2002
    ..6 +/- 8.8 mm Hg), and brain cytokine concentrations. However, the combination of urate and ascorbate was as effective as MnTBAP (CSF pleocytosis: 5392 +/- 4232 cells/microl, intracranial pressure: 13.3 +/- 6.9 mm Hg)...
  73. ncbi Cerebral output of cytokines in patients with pneumococcal meningitis
    Francois G Brivet
    Crit Care Med 33:2721-2; author reply 2722-3. 2005
  74. pmc Genetic relationship between Streptococcus pneumoniae isolates from nasopharyngeal and cerebrospinal fluid of two infants with Pneumococcal Meningitis
    Ana Lucia Sampaio Sgambatti de Andrade
    Institute of Tropical Pathology and Public Health, Federal University of Goias, Brazil
    J Clin Microbiol 41:3970-2. 2003
    ..By using pulsed-field gel electrophoresis, we demonstrated the genetic linkage among strains from CSF and nasopharynges of two children with pneumococcal meningitis.
  75. ncbi Cerebral output of cytokines in patients with pneumococcal meningitis
    Kirsten Møller
    Departments of Infectious Diseases, University Hospital Rigshospitalet, Copenhagen, Denmark
    Crit Care Med 33:979-83. 2005
    ..However, it is unknown whether the brain contributes to the intravascular accumulation of cytokines in meningitis. We measured the cerebral output of cytokines to the blood during severe pneumococcal meningitis accompanied by sepsis.
  76. ncbi Combined treatment with ceftriaxone and linezolid of pneumococcal meningitis: a case series including penicillin-resistant strains
    F Faella
    Department of Emergency, Division of Infectious Neuropathies, D Cotugno Hospital, Naples, Italy
    Clin Microbiol Infect 12:391-4. 2006
    This study evaluated the role of linezolid in the treatment of patients suffering from pneumococcal meningitis. Treatment included ceftriaxone (4000 mg every 24 h), linezolid (600 mg every 12 h) and dexamethasone (8 mg every 6 h)...
  77. ncbi Carriage of multidrug-resistant Streptococcus pneumoniae and impact of chemoprophylaxis during an outbreak of meningitis at a day care center
    A S Craig
    Tennessee Department of Health, Communicable and Environmental Disease Services, Nashville, TN 37247 5281, USA
    Clin Infect Dis 29:1257-64. 1999
    ..DCC contacts of the ill children were offered chemoprophylaxis with rifampin and clindamycin, which produced a profound but transient decrease in carriage. No additional cases occurred...
  78. ncbi Otologic sequelae after pneumococcal meningitis: a survey of 164 consecutive cases with a follow-up of 94 survivors
    N Rasmussen
    University Ear, Nose and Throat Department, Rigshospitalet, Copenhagen, Denmark
    Laryngoscope 101:876-82. 1991
    As part of a comprehensive study on sequelae after pneumococcal meningitis, 94 of 111 consecutive survivors were re-examined 4 to 16 years after discharge. Twenty-three patients had otological sequelae after pneumococcal meningitis...
  79. ncbi Surveillance of pneumococcal meningitis among children in Sindh, southern Pakistan
    Anita K M Zaidi
    Department of Paediatrics and Child Health, Aga Khan University, Karachi, Pakistan
    Clin Infect Dis 48:S129-35. 2009
    ..Information about the burden of invasive pneumococcal disease among children in Pakistan is limited...
  80. ncbi Pneumococcal meningitis in the intensive care unit: prognostic factors of clinical outcome in a series of 80 cases
    Marc Auburtin
    Medical Intensive Care Unit, Microbiology Laboratory, Hospital Bichat Claude Bernard, 46 rue Henri Huchard, Paris, France
    Am J Respir Crit Care Med 165:713-7. 2002
    ..pneumoniae meningitis, hyperventilation should be used with caution. Nonsusceptibility to penicillin G is not associated with a worse outcome. High-dose corticosteroids may be beneficial in the most severely ill patients...
  81. ncbi Delayed cerebral thrombosis after initial good recovery from pneumococcal meningitis
    E S Schut
    Department of Neurology, Center of Infection and Immunity Amsterdam, Academic Medical Center, Amsterdam, The Netherlands
    Neurology 73:1988-95. 2009
    ..To report an unusual clinical course in 6 patients with community-acquired acute bacterial meningitis and to compare clinical features with cases reported in the literature...
  82. ncbi Urokinase-type plasminogen activator receptor regulates leukocyte recruitment during experimental pneumococcal meningitis
    Robert Paul
    Department of Neurology, Klinikum Grosshadern, Ludwig Maximilians University, Munich, Germany
    J Infect Dis 191:776-82. 2005
    ..Here, we show that expression of tPA, uPA, uPAR, PAI-1, and PAI-2 is up-regulated during experimental pneumococcal meningitis. In uPAR-deficient mice, CSF pleocytosis was significantly attenuated 24 h after infection, compared with ..
  83. ncbi Enriched environment fails to increase meningitis-induced neurogenesis and spatial memory in a mouse model of pneumococcal meningitis
    Simone C Tauber
    Department of Neurology, Georg August University, Gottingen, Germany
    J Neurosci Res 87:1877-83. 2009
    ..was observed after exposure to enriched environment (EE) and during reconvalescence from experimental pneumococcal meningitis. This study investigated neurogenesis and spatial learning performance 5 weeks after bacterial meningitis ..
  84. ncbi Reactive nitrogen species contribute to blood-labyrinth barrier disruption in suppurative labyrinthitis complicating experimental pneumococcal meningitis in the rat
    S Kastenbauer
    Department of Neurology, Klinikum Grossetahadern, Ludwig-Maximilians University, Munich, Germany
    Brain Res 904:208-17. 2001
    ..damage is a frequent complication of bacterial meningitis, affecting as many as 30% of survivors of pneumococcal meningitis. There is a substantial body of evidence that oxidants, such as reactive nitrogen species (RNS), are ..
  85. ncbi Effects of Toll-like receptor 2 agonist Pam(3)CysSK(4) on inflammation and brain damage in experimental pneumococcal meningitis
    Johann Sellner
    Department of Neurology, Klinikum rechts der Isar, Technische Universitat Munchen, Ismaninger Str 22, D 81675 Munchen, Germany
    J Neuroimmunol 206:28-31. 2009
    TLR2 signaling participates in the pathogenesis of pneumococcal meningitis. In infant rats, the TLR2 agonist Pam(3)CysSK(4) was applied intracisternally (0...
  86. ncbi [Pneumococcal meningitis in children in France: 832 cases from 2001 to 2007]
    C Levy
    GPIP Groupe de Pathologie Infectieuse Pédiatrique de la SFP Société Française de Pédiatrie, 27 rue Inkermann, F94100 Saint Maur des Fossés, France
    Arch Pediatr 15:S111-8. 2008
    b>Pneumococcal meningitis represents one major cause of morbidity and mortality in children in France...
  87. ncbi Austrian syndrome in a child-aortic valve endocarditis following pneumococcal meningitis
    Lukas Rammeloo
    Int J Cardiol 94:321-2. 2004
    ..b>Pneumococcal meningitis and aortic valve endocarditis is a known combination, described as Austrian syndrome...
  88. pmc JNK is activated but does not mediate hippocampal neuronal apoptosis in experimental neonatal pneumococcal meningitis
    Matthias D Sury
    Institute of Infectious Diseases, University of Berne, Berne, Switzerland
    Neurobiol Dis 32:142-50. 2008
    b>Pneumococcal meningitis is associated with caspase 3-dependent apoptosis of recently post-mitotic immature neurons in the dentate gyrus of the hippocampus...
  89. pmc Bacteremia is associated with a worse outcome in pneumococcal meningitis
    Enitan D Carrol
    J Infect Dis 198:626-7. 2008
  90. ncbi Long-term mortality in patients diagnosed with pneumococcal meningitis: a Danish nationwide cohort study
    Casper Roed
    Department of Infectious Diseases, Rigshospitalet, and University of Copenhagen, Copenhagen, Denmark
    Am J Epidemiol 172:309-17. 2010
    ..of the study was to determine the long-term mortality and the causes of death in patients diagnosed with pneumococcal meningitis. The authors performed a nationwide, population-based cohort study including all Danish patients ..
  91. ncbi Insidious presentation of pediatric pneumococcal meningitis: alive and well in the post vaccine era
    Jay D Fisher
    University of Nevada School of Medicine, University Medical Center, Las Vegas, NV, USA
    Am J Emerg Med 27:1173.e5-7. 2009
    ..In this report, we present 3 cases of pneumococcal meningitis in young infants presenting with indolent features...
  92. pmc Attenuation of cerebrospinal fluid inflammation by the nonbacteriolytic antibiotic daptomycin versus that by ceftriaxone in experimental pneumococcal meningitis
    Denis Grandgirard
    Laboratory for Experimental Neuroinfectiology, Institute for Infectious Diseases, University of Bern, Bern, Switzerland
    Antimicrob Agents Chemother 54:1323-6. 2010
    ..quality and temporal kinetics of cerebrospinal fluid (CSF) inflammation were assessed in an infant rat pneumococcal meningitis model for the nonbacteriolytic antibiotic daptomycin versus ceftriaxone...
  93. ncbi Time-dependent behavioral recovery after pneumococcal meningitis in rats
    Tatiana Barichello
    Laboratory of Microbiology and National Institute for Translational Medicine, Postgraduate Program in Health Sciences, Health Sciences Unit, University of Southern Santa Catarina, 88806 000, Criciuma, SC, Brazil
    J Neural Transm 117:819-26. 2010
    ..We demonstrated that some of the learning and memory impairment, demonstrated 10 days after the induction of meningitis, persists up to 30 days, but not 60 days after induction...
  94. ncbi Interleukin-18 gene-deficient mice show enhanced defense and reduced inflammation during pneumococcal meningitis
    Petra J G Zwijnenburg
    Department of Pediatrics, Vrije Universiteit Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    J Neuroimmunol 138:31-7. 2003
    To determine the role of endogenous interleukin-18 (IL-18) in pneumococcal meningitis, meningitis was induced in IL-18 gene-deficient (IL-18(-/-)) and wild-type (WT) mice by intranasal inoculation of Streptococcus pneumoniae with ..
  95. pmc Clinical presentation and prognostic factors of Streptococcus pneumoniae meningitis according to the focus of infection
    Christian Østergaard
    National Center for Antimicrobials and Infection Control, Statens Serum Institut, Artillerivej 5, Copenhagen S, Denmark
    BMC Infect Dis 5:93. 2005
    ..We conducted a nationwide study in Denmark to identify clinical features and prognostic factors in patients with Streptococcus pneumoniae according to the focus of infection...
  96. ncbi Pathophysiology of bacterial meningitis: mechanism(s) of neuronal injury
    W Michael Scheld
    Division of Infectious Diseases, Department of Internal Medicine, University of Virginia School of Medicine, PO Box 801342, Charlottesville, VA 22908, USA
    J Infect Dis 186:S225-33. 2002
    ....
  97. ncbi The risk of sequelae due to pneumococcal meningitis in high-income countries: a systematic review and meta-analysis
    Mark Jit
    Modelling and Economics Unit, Health Protection Agency Centre for Infections, London, UK
    J Infect 61:114-24. 2010
    ..To determine the risk of various kinds of sequelae in survivors of meningitis due to Streptococcus pneumoniae, as well as the influence of co-factors such as study design, study population and treatment on this risk...
  98. ncbi Matrix metalloproteinase (MMP)-8 and MMP-9 in cerebrospinal fluid during bacterial meningitis: association with blood-brain barrier damage and neurological sequelae
    D Leppert
    Departments of Research and Neurology, University Hospitals, CH 4031 Basel, Switzerland
    Clin Infect Dis 31:80-4. 2000
    ..High concentrations of MMP-9 are a risk factor for the development of postmeningitidal neurological sequelae...
  99. ncbi Pneumococcal meningitis in adults: spectrum of complications and prognostic factors in a series of 87 cases
    Stefan Kastenbauer
    Department of Neurology, Klinikum Grosshadern, Ludwig Maximilians University, Munich, Germany
    Brain 126:1015-25. 2003
    Studies on the incidence and spectrum of complications and prognostic factors in adults with pneumococcal meningitis are scarce. Therefore, we analysed 87 consecutive cases who were treated in our department between 1984 and 2002...
  100. ncbi Matrix metalloproteinase-9 in pneumococcal meningitis: activation via an oxidative pathway
    Damian N Meli
    Institute for Infectious Diseases, University of Bern, Bern, Switzerland
    J Infect Dis 187:1411-5. 2003
    ..MMP-9 activation by ROS may represent a target for therapeutic intervention in bacterial meningitis...
  101. ncbi Dexamethasone in adults with bacterial meningitis
    Jan de Gans
    Department of Neurology, Academic Medical Center, Amsterdam, The Netherlands
    N Engl J Med 347:1549-56. 2002
    Mortality and morbidity rates are high among adults with acute bacterial meningitis, especially those with pneumococcal meningitis. In studies of bacterial meningitis in animals, adjuvant treatment with corticosteroids has beneficial ..

Research Grants12

  1. Transmission of Drug-Resistant S. pneumoniae in Brazil
    JOICE PEDREIRA; Fiscal Year: 2009
    ..Since 1996, we have established at Fiocruz a continuous surveillance for pneumococcal meningitis and recently implemented the field site infrastructure to conduct longitudinal community-based studies...
  2. Lethal synergism between influenza and pneumococcus
    Jonathan McCullers; Fiscal Year: 2003
    ....
  3. Study of risk factors of tick-borne encephalitis in Poland
    Pawel Stefanoff; Fiscal Year: 2009
    ....
  4. Synergism Between Influenza Virus and Pneumococcus
    Jonathan McCullers; Fiscal Year: 2009
    ....
  5. Appropriate Pneumococcal Vaccination in Infants in Fiji
    Fiona Russell; Fiscal Year: 2007
    ..The project has evaluated the burden of pneumonia, otitis media and pneumococcal meningitis in Fijian infants...
  6. Optimal Strategies for PID Prevention and Management
    Kenneth Smith; Fiscal Year: 2007
    ..abstract_text> ..
  7. CONTROL OF AUTOLYSIS IN PNEUMOCOCCI
    Elaine Tuomanen; Fiscal Year: 2006
    ..abstract_text> ..
  8. 3rd Orthomyxoviruses Research Conference
    Jonathan McCullers; Fiscal Year: 2005
    ..The purpose of this proposal is to provide funds that will allow promising young investigators to interact with their peers and develop a commitment to this area of research. ..
  9. Gene Discovery for Pneumococcal Otitis Media
    Melinda Pettigrew; Fiscal Year: 2005
    ..Discovery of additional factors involved in streptococcal OM will facilitate the development of new strategies for the control and prevention of this important disease. ..
  10. Influenza-pneumococcal synergism: role of neuraminidase
    Jonathan McCullers; Fiscal Year: 2004
    ....
  11. 2nd Orthomyxoviruses Research Conference
    Jonathan McCullers; Fiscal Year: 2003
    ..The purpose of this proposal is to provide funds that will allow promising young investigators to interact with their peers and develop a commitment to this area of research. ..
  12. Molecular epidemiologic identification of pneumococcal tissue specific genes
    MELINDA MARY PETTIGREW; Fiscal Year: 2010
    ..A greater understanding of the genetic factors that influence the virulence potential of pneumococcal clones is critical to our ability to develop effective methods to control, prevent, and treat these important infections. ..