meningeal tuberculosis

Summary

Summary: A form of bacterial meningitis caused by MYCOBACTERIUM TUBERCULOSIS or rarely MYCOBACTERIUM BOVIS. The organism seeds the meninges and forms microtuberculomas which subsequently rupture. The clinical course tends to be subacute, with progressions occurring over a period of several days or longer. Headache and meningeal irritation may be followed by SEIZURES, cranial neuropathies, focal neurologic deficits, somnolence, and eventually COMA. The illness may occur in immunocompetent individuals or as an OPPORTUNISTIC INFECTION in the ACQUIRED IMMUNODEFICIENCY SYNDROME and other immunodeficiency syndromes. (From Adams et al., Principles of Neurology, 6th ed, pp717-9)

Top Publications

  1. ncbi Dexamethasone for the treatment of tuberculous meningitis in adolescents and adults
    Guy E Thwaites
    Oxford University Clinical Research Unit at the Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
    N Engl J Med 351:1741-51. 2004
  2. ncbi The clinical, radiological and pathological profile of tuberculous meningitis in patients with and without human immunodeficiency virus infection
    S M Katrak
    Department of Neurology, Grant Medical College and JJ Group of Hospitals, 400 008, Mumbai, India
    J Neurol Sci 181:118-26. 2000
  3. ncbi Diagnostic accuracy of nucleic acid amplification tests for tuberculous meningitis: a systematic review and meta-analysis
    Madhukar Pai
    Division of Epidemiology, University of California, Berkeley, CA 94720, USA
    Lancet Infect Dis 3:633-43. 2003
  4. pmc Demonstration of components of antigen 85 complex in cerebrospinal fluid of tuberculous meningitis patients
    Rajpal S Kashyap
    Biochemistry Research Laboratory, Central India Institute of Medical Sciences, 88 2 Bajaj Nagar, Nagpur 440010, India
    Clin Diagn Lab Immunol 12:752-8. 2005
  5. ncbi The use of maximum likelihood methods to estimate the risk of tuberculous infection and disease in a Canadian First Nations population
    Michael Clark
    First Nations and Inuit Health Branch, Health Canada, Ottawa, Canada
    Int J Epidemiol 33:477-84. 2004
  6. ncbi Diagnosis of adult tuberculous meningitis by use of clinical and laboratory features
    G E Thwaites
    University of Oxford Wellcome Trust Clinical Research Unit, Centre for Tropical Diseases, 190 Ben Ham Tu, Quan 5, Ho Chi Minh City, Viet Nam
    Lancet 360:1287-92. 2002
  7. ncbi Pretreatment intracerebral and peripheral blood immune responses in Vietnamese adults with tuberculous meningitis: diagnostic value and relationship to disease severity and outcome
    Cameron P Simmons
    Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
    J Immunol 176:2007-14. 2006
  8. pmc Improving the bacteriological diagnosis of tuberculous meningitis
    Guy E Thwaites
    Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
    J Clin Microbiol 42:378-9. 2004
  9. pmc Relationship between Mycobacterium tuberculosis genotype and the clinical phenotype of pulmonary and meningeal tuberculosis
    Guy Thwaites
    Centre for Molecular Microbiology and Infection, Imperial College, Exhibition Rd, South Kensington, London, United Kingdom
    J Clin Microbiol 46:1363-8. 2008
  10. ncbi Virulence of selected Mycobacterium tuberculosis clinical isolates in the rabbit model of meningitis is dependent on phenolic glycolipid produced by the bacilli
    Liana Tsenova
    Laboratory of Mycobacterial Immunity and Pathogenesis, The Public Health Research Institute, Newark, New Jersey 07103, USA
    J Infect Dis 192:98-106. 2005

Research Grants

  1. Intercellular trafficking of labeled aminoglycosides in living hair cells
    Dale Warren Hailey; Fiscal Year: 2013
  2. Structural Topology of a Small Multidrug Resistant Efflux Pump
    Nathaniel J Traaseth; Fiscal Year: 2012
  3. Training in Host-pathogens interactions
    David M Mosser; Fiscal Year: 2013
  4. M Tuberculosis CTL Epitopes: Vaccine Design/Evaluation
    Elizabeth Mellins; Fiscal Year: 2007
  5. QSTAR Elite Quadrupole-o-TOF LC/MS/MS System
    Bradford Gibson; Fiscal Year: 2007
  6. Toll-like Receptors and the Innate Immune Response
    THOMAS HAWN; Fiscal Year: 2003
  7. TLR5 and Pulmonary Innate Immunity
    THOMAS HAWN; Fiscal Year: 2009
  8. Fluoroquinolone Resistance in M. Tuberculosis
    Timothy R Sterling; Fiscal Year: 2010

Detail Information

Publications182 found, 100 shown here

  1. ncbi Dexamethasone for the treatment of tuberculous meningitis in adolescents and adults
    Guy E Thwaites
    Oxford University Clinical Research Unit at the Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
    N Engl J Med 351:1741-51. 2004
    ....
  2. ncbi The clinical, radiological and pathological profile of tuberculous meningitis in patients with and without human immunodeficiency virus infection
    S M Katrak
    Department of Neurology, Grant Medical College and JJ Group of Hospitals, 400 008, Mumbai, India
    J Neurol Sci 181:118-26. 2000
    ..However, such differences have not been reported in tuberculous meningitis (TBM). Here, we therefore compared the clinical, radiological and pathological features of TBM in patients with and without HIV infection...
  3. ncbi Diagnostic accuracy of nucleic acid amplification tests for tuberculous meningitis: a systematic review and meta-analysis
    Madhukar Pai
    Division of Epidemiology, University of California, Berkeley, CA 94720, USA
    Lancet Infect Dis 3:633-43. 2003
    ..On current evidence, commercial NAA tests show a potential role in confirming tuberculous meningitis diagnosis, although their overall low sensitivity precludes the use of these tests to rule out tuberculous meningitis with certainty...
  4. pmc Demonstration of components of antigen 85 complex in cerebrospinal fluid of tuberculous meningitis patients
    Rajpal S Kashyap
    Biochemistry Research Laboratory, Central India Institute of Medical Sciences, 88 2 Bajaj Nagar, Nagpur 440010, India
    Clin Diagn Lab Immunol 12:752-8. 2005
    ..Therefore, this finding suggests that this protein can be used as a molecular marker for any type of tuberculous infection. It also provides a more sensitive immunoassay option for the early and confirmatory diagnosis of TBM...
  5. ncbi The use of maximum likelihood methods to estimate the risk of tuberculous infection and disease in a Canadian First Nations population
    Michael Clark
    First Nations and Inuit Health Branch, Health Canada, Ottawa, Canada
    Int J Epidemiol 33:477-84. 2004
    ..The epidemiology of tuberculous infection and disease during the period 1926-2000 in this population was investigated...
  6. ncbi Diagnosis of adult tuberculous meningitis by use of clinical and laboratory features
    G E Thwaites
    University of Oxford Wellcome Trust Clinical Research Unit, Centre for Tropical Diseases, 190 Ben Ham Tu, Quan 5, Ho Chi Minh City, Viet Nam
    Lancet 360:1287-92. 2002
    ..We aimed to create a simple diagnostic aid for tuberculous meningitis in adults on the basis of clinical and basic laboratory features...
  7. ncbi Pretreatment intracerebral and peripheral blood immune responses in Vietnamese adults with tuberculous meningitis: diagnostic value and relationship to disease severity and outcome
    Cameron P Simmons
    Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
    J Immunol 176:2007-14. 2006
    ....
  8. pmc Improving the bacteriological diagnosis of tuberculous meningitis
    Guy E Thwaites
    Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
    J Clin Microbiol 42:378-9. 2004
    ..Volume of cerebrospinal fluid, duration of symptoms, cerebrospinal fluid neutrophils, lactate, and glucose were all independently associated with bacteriological confirmation...
  9. pmc Relationship between Mycobacterium tuberculosis genotype and the clinical phenotype of pulmonary and meningeal tuberculosis
    Guy Thwaites
    Centre for Molecular Microbiology and Infection, Imperial College, Exhibition Rd, South Kensington, London, United Kingdom
    J Clin Microbiol 46:1363-8. 2008
    ..The genotype of M. tuberculosis influenced the presenting features of pulmonary and meningeal tuberculosis. The association between the East Asian/Beijing lineage and disease progression and CSF leukocyte count ..
  10. ncbi Virulence of selected Mycobacterium tuberculosis clinical isolates in the rabbit model of meningitis is dependent on phenolic glycolipid produced by the bacilli
    Liana Tsenova
    Laboratory of Mycobacterial Immunity and Pathogenesis, The Public Health Research Institute, Newark, New Jersey 07103, USA
    J Infect Dis 192:98-106. 2005
    ....
  11. ncbi British Infection Society guidelines for the diagnosis and treatment of tuberculosis of the central nervous system in adults and children
    Guy Thwaites
    Centre for Molecular Microbiology and Infection, Imperial College, Exhibition Road, South Kensington, London, UK
    J Infect 59:167-87. 2009
    ..The co-administration of anti-retroviral and anti-tuberculosis drugs should follow guidance issued by the British HIV association (www.bhiva.org)...
  12. ncbi Rapid diagnosis of tuberculous meningitis using the Simple Dot ELISA method
    Rajpal S Kashyap
    Biochemistry Research Laboratory, Central India Institute of Medical Sciences, 88 2 Bajaj Nagar, Nagpur 440010, India
    Med Sci Monit 9:MT123-6. 2003
    ..Dot Enzyme Linked Immunosorbent assay (Dot ELISA) has been standardized to detect MTB antigens and antibodies against MTB in the CSF of TBM patients...
  13. ncbi Detection of heat stable mycobacterial antigen in cerebrospinal fluid by Dot-Immunobinding assay
    A Mathai
    Department of Pathology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram 695011, Kerala, India
    Neurol India 51:52-4. 2003
    ..Thus development of an alternative laboratory diagnostic test is essential for the early diagnosis and treatment of TBM...
  14. ncbi Tuberculous meningitis: many questions, too few answers
    Guy E Thwaites
    Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, Oxford University, UK
    Lancet Neurol 4:160-70. 2005
    ..There are many important unanswered questions about the pathophysiology, diagnosis, and treatment of TM. Here we review the available evidence to answer some of these questions, particularly those on the diagnosis and treatment of TM...
  15. pmc Comparison of conventional bacteriology with nucleic acid amplification (amplified mycobacterium direct test) for diagnosis of tuberculous meningitis before and after inception of antituberculosis chemotherapy
    Guy E Thwaites
    Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
    J Clin Microbiol 42:996-1002. 2004
    ..However, the combination of these methods on serial samples detects more cases. Alternative tests are still urgently required...
  16. ncbi Marked increase of matrix metalloproteinase 9 in cerebrospinal fluid of patients with fungal or tuberculous meningoencephalitis
    E Matsuura
    The Third Department of Internal Medicine, Kagoshima University School of Medicine, 8 35 1, Sakuragaoka, Kagoshima City, Kagoshima, Japan
    J Neurol Sci 173:45-52. 2000
    ..Taken together, those data suggest that MMP-9 in CSF may be a useful marker of encephalitogenecity during the course of subacute meningitis...
  17. ncbi The influence of HIV infection on clinical presentation, response to treatment, and outcome in adults with Tuberculous meningitis
    Guy E Thwaites
    Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam
    J Infect Dis 192:2134-41. 2005
    ..Tuberculous meningitis occurs more commonly in human immunodeficiency virus (HIV)-infected individuals than in HIV-uninfected individuals, but whether HIV infection alters the presentation and outcome of tuberculous meningitis is unknown...
  18. ncbi A polymorphism in Toll-interleukin 1 receptor domain containing adaptor protein is associated with susceptibility to meningeal tuberculosis
    Thomas R Hawn
    Department of Medicine, University of Washington School of Medicine, Seattle WA 98195, USA
    J Infect Dis 194:1127-34. 2006
    ....
  19. ncbi Predictors of outcome in patients with tuberculous meningitis
    S Hosoglu
    Department of Clinical Microbiology, Dicle University Hospital, Diyarbakir, Turkey
    Int J Tuberc Lung Dis 6:64-70. 2002
    ..To assess predictors of mortality and neurological sequelae in patients with tuberculous meningitis (TBM)...
  20. ncbi Tuberculous meningitis and HIV
    Sunil Karande
    Division of Pediatric Neurology, Department of Pediatrics, Lokmanya Tilak Municipal Medical College and General Hospital, Sion, Mumbai, India
    Indian J Pediatr 72:755-60. 2005
    ..To identify factors associated with HIV-infected status in children admitted with tuberculous meningitis (TBM), and to find out whether HIV co-infection affects in-hospital outcome...
  21. ncbi Assessment of antibody responses to antigens of Mycobacterium tuberculosis and Cysticercus cellulosae in cerebrospinal fluid of chronic meningitis patients for definitive diagnosis as TBM/NCC by passive hemagglutination and immunoblot assays
    Muralidhar K Katti
    Immunology Laboratory, Department of Microbiology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvanathapuram 695 011, India
    FEMS Immunol Med Microbiol 33:57-61. 2002
    ..However, findings of this study should alert laboratory personnel especially in endemic areas to be extra careful in interpretation of antibody detection results...
  22. ncbi Clinical, cerebrospinal fluid and pathological findings and outcomes in HIV-positive and HIV-negative patients with tuberculous meningitis
    C M Schutte
    Dept of Neurology, Pretoria, Republic of South Africa
    Infection 29:213-7. 2001
    ..This study aimed to analyze clinical, cerebrospinal fluid (CSF) and pathological findings and outcomes in TB meningitis to evaluate whether HIV infection significantly influences the characteristic findings...
  23. ncbi Effect of methyl prednisolone on sensory motor functions in tuberculous meningitis
    J Kalita
    Department of Neurology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226 014, India
    Neurol India 49:267-71. 2001
    ..On the contrary, the control group fared significantly better than the MPS group. Initial MEP and SEP abnormalities were however related to 3 months outcome (p<0.01)...
  24. ncbi Persistent increase of matrix metalloproteinases in cerebrospinal fluid of tuberculous meningitis
    Kyung Yul Lee
    Department of Neurology, Yongdong Severance Hospital, Brain Korea 21 Project for Medical Sciences, Yonsei University College of Medicine, Seoul, South Korea
    J Neurol Sci 220:73-8. 2004
    ..Inhibiting the MMPs may be an effective strategy for preventing or reducing the complications in tuberculous meningitis...
  25. ncbi The effect of adjuvant steroid treatment on serial cerebrospinal fluid changes in tuberculous meningitis
    J F Schoeman
    Tygerberg Children s Hospital, Faculty of Health Sciences, University of Stellenbosch, Cape Town, Republic of South Africa
    Ann Trop Paediatr 21:299-305. 2001
    ..Knowledge of the different CSF responses during the course of anti-tuberculosis therapy is important in clinical decision-making...
  26. ncbi Pathophysiology and prognosis in vietnamese adults with tuberculous meningitis
    Guy E Thwaites
    Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam
    J Infect Dis 188:1105-15. 2003
    ..Death was associated with high initial CSF concentrations of lactate, low numbers of white blood cells, in particular neutrophils, and low CSF glucose levels...
  27. ncbi Demonstration of IgG antibodies to 30 Kd protein antigen in CSF for diagnosis of tuberculous meningitis by antibody-capturing ELISA
    R S Kashyap
    Biochemistry Rresearch Laboratory, Central India Institute of Medical Sciences, Nagpur, India
    Neurol India 52:359-62. 2004
    ..A simple and rapid immunological assay method has been developed to demonstrate the presence of IgG antibodies to 30Kd protein antigen (30Kdpa) and culture filtrate protein (CFP) in the CSF of patients with Tuberculous meningitis (TBM)...
  28. ncbi The clinical benefit of adjunctive dexamethasone in tuberculous meningitis is not associated with measurable attenuation of peripheral or local immune responses
    Cameron P Simmons
    Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
    J Immunol 175:579-90. 2005
    ..These findings challenge previously held theories of corticosteroid action in this disease. An understanding of how dexamethasone acts in TBM may suggest novel and more effective treatment strategies...
  29. ncbi Identification of a matrix-degrading phenotype in human tuberculosis in vitro and in vivo
    N M Price
    Department of Infectious Diseases, Imperial College School of Medicine, Hammersmith Hospital, London, United Kingdom
    J Immunol 166:4223-30. 2001
    ..In summary, M. tuberculosis-infected monocytic cells develop a matrix-degrading phenotype, which was observed in vivo and relates to clinical signs reflecting cerebral injury in tuberculous meningitis...
  30. ncbi [Tuberculous meningitis in adults: review of 53 cases]
    Margarita Enberg G
    Hospital de Enfermedades Infecciosas Dr Lucio Córdova, Santiago, Chile
    Rev Chilena Infectol 23:134-9. 2006
    ..TBM is still a present diagnostic problem, in spite of the new diagnostic methods. A high index of suspicion is required in order to make an early diagnosis...
  31. ncbi Neuro-ophthalmic features in pediatric tubercular meningoencephalitis
    A K Amitava
    Institute of Ophthalmology, Jawaharlal Nehru Medical College, Aligarh Muslim University, India
    J Pediatr Ophthalmol Strabismus 38:229-34. 2001
    ..The type of neuro-ophthalmic features may have prognostic value. Optic nerve involvement is the most common finding in tubercular meningoencephalitis...
  32. ncbi Isoniazid resistance, mycobacterial genotype and outcome in Vietnamese adults with tuberculous meningitis
    G E Thwaites
    Nuffield Department of Clinical Medicine, John Radcliffe Hospital, University of Oxford, UK
    Int J Tuberc Lung Dis 6:865-71. 2002
    ..Centre for Tropical Diseases, a 500-bed hospital for infectious diseases in Ho Chi Minh City, Vietnam...
  33. ncbi Multidrug-resistant tuberculous meningitis in KwaZulu-Natal, South Africa
    V B Patel
    Department of Neurology, Nelson R Mandela School of Medicine, University of Natal, Durban, South Africa
    Clin Infect Dis 38:851-6. 2004
    ..The study highlights the prevalence of MDR-TBM and identifies new challenges in the management of affected patients...
  34. ncbi Predictors of long-term neurological sequelae of tuberculous meningitis: a multivariate analysis
    J Kalita
    Department of Neurology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India
    Eur J Neurol 14:33-7. 2007
    ..Neurological sequelae at year occurred in 78.5% patients with TBM in the form of cognitive impairment, motor deficit and optic atrophy. Sequelae were common in patients who had focal motor deficit and altered sensorium at admission...
  35. ncbi The application of the Mancini technique as a diagnostic test in the CSF of tuberculous meningitis patients
    Rajpal S Kashyap
    Biochemistry Research Laboratory and Department of Neurological Sciences, Central India Institute of Medical Sciences, Nagpur, India
    Med Sci Monit 8:MT95-8. 2002
    ..To establish a rapid diagnosis, we used Single Radial Immuno-Diffusion (SRID) to detect circulating mycobacterium antigen in the CSF of patients with clinically suspected TBM...
  36. ncbi The use of adjunctive corticosteroids in the treatment of pericardial, pleural and meningeal tuberculosis: do they improve outcome?
    D J Evans
    Hemel Hempstead Hospital, Hillfield Road, Hemel Hempstead, Herts, HP2 4AD, UK
    Respir Med 102:793-800. 2008
    ..Rapid improvements in clinical parameters for pleural effusion were not supported by any lasting improved outcomes for these patients...
  37. ncbi Meningeal tuberculosis: high long-term mortality despite standard therapy
    Joanna E T Shaw
    University of Texas Southwestern Medical Center, Dallas, Texas 75390 9113, USA
    Medicine (Baltimore) 89:189-95. 2010
    ..07% of controls. The long-term outlook in patients with proven tuberculous meningitis adequately treated with current standard tuberculous therapy is bleak. A re-examination of treatment strategies is urgently needed...
  38. ncbi Immune function in young children with previous pulmonary or miliary/meningeal tuberculosis and impact of BCG vaccination
    Timothy R Sterling
    Division of Infectious Diseases, Vanderbilt University School of Medicine, Nashville, TN 37232 2605, USA
    Pediatrics 120:e912-21. 2007
    Children <5 years old are at increased risk of miliary/meningeal tuberculosis, but the immunologic factors that place them at risk are unknown...
  39. ncbi [Tuberculous meningitis: a comparative study in relation to concurrent human immunodeficiency virus infection]
    Carlos Azuaje
    Servicios de Enfermedades Infecciosas, Hospital Universitario Vall d Hebron, Passeig Vall d Hebron 119 129, 08035 Barcelona, Spain
    Enferm Infecc Microbiol Clin 24:245-50. 2006
    ..A comparative study was conducted between adult MT patients with and without concurrent human immunodeficiency virus (HIV) infection...
  40. ncbi Effect of antituberculosis drug resistance on response to treatment and outcome in adults with tuberculous meningitis
    Guy E Thwaites
    Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
    J Infect Dis 192:79-88. 2005
    ..Tuberculous meningitis (TBM) caused by Mycobacterium tuberculosis resistant to 1 or more antituberculosis drugs is an increasingly common clinical problem, although the impact on outcome is uncertain...
  41. ncbi Serodiagnosis of extra pulmonary tuberculosis using A-60 antigen
    S Anuradha
    Department of Medicine and Microbiology, Maulana Azad Medical College and Associated Lok Nayak Jaiprakash Hospital, New Delhi
    J Commun Dis 33:12-6. 2001
    ..7%. To conclude, testing for antimycobacterial antibodies to A-60 antigen is a useful adjunct in the diagnosis of extrapulmonary tuberculosis especially neurotuberculosis...
  42. ncbi Serial MRI to determine the effect of dexamethasone on the cerebral pathology of tuberculous meningitis: an observational study
    Guy E Thwaites
    Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
    Lancet Neurol 6:230-6. 2007
    ..We aimed to determine the effect of dexamethasone on cerebral MRI changes and their association with intracerebral inflammatory responses and clinical outcome in adults treated for tuberculous meningitis...
  43. ncbi Nested polymerase chain reaction for assessing the clinical course of tuberculous meningitis
    T Takahashi
    Division of Neurology, Advanced Medical Research Center, Nihon University School of Medicine, Tokyo, Japan
    Neurology 64:1789-93. 2005
    ..During anti-tuberculosis treatments, N-PCR results converted from positive to negative, correlating with the improvement of the patient's clinical condition...
  44. ncbi Tuberculous meningitis
    Sascha Meyer
    Department of Paediatrics, University Hospital of the Saarland, Kirrbergerstr, 66421 Homburg, Germany
    Lancet 367:1682. 2006
  45. pmc Differential diagnosis of tuberculous meningitis from partially-treated pyogenic meningitis by cell ELISA
    Rajpal S Kashyap
    Biochemistry Research Laboratory, Central India Institute of Medical Sciences, 88 2 Bajaj Nagar, Nagpur 440010, India
    BMC Neurol 4:16. 2004
    ..We have also shown that lymphocytes from CSF of TBM patients respond differently to this antigen than do those from PTPM patients. The purpose of this study was to develop an assay that can discriminate between TBM and PTPM...
  46. ncbi [Tuberculosis--current therapeutic concepts]
    F Grunhage
    Medizinische Klinik und Poliklinik I, Universitätsklinik Bonn
    Dtsch Med Wochenschr 130:159-64. 2005
  47. ncbi Vascular endothelial growth factor and blood-brain barrier disruption in tuberculous meningitis
    Michiel van der Flier
    Eijkman Winkler Institute, Department of Medicine, University Medical Center Utrecht, Utrecht, The Netherlands
    Pediatr Infect Dis J 23:608-13. 2004
    ..Vascular endothelial growth factor (VEGF) is a potent vascular permeability factor and a mediator of brain edema...
  48. ncbi A case of tuberculous meningoencephalitis in a patient with Behçet's disease
    Alexios Iliopoulos
    Clin Rheumatol 25:121-2. 2006
  49. ncbi Tuberculous radiculomyelitis (arachnoiditis) associated with tuberculous meningitis
    Verajit Chotmongkol
    Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
    Southeast Asian J Trop Med Public Health 36:722-4. 2005
    ..Hemi-larminectomy and removal of the arachnoid cyst were performed, but without improvement. A CSF culture yielded M. tuberculosis, that was susceptible to anti-tuberculous drugs...
  50. ncbi Molecular analysis of Mycobacterium tuberculosis causing multidrug-resistant tuberculosis meningitis
    M Caws
    Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
    Int J Tuberc Lung Dis 11:202-8. 2007
    ..Tertiary referral hospitals in southern Vietnam...
  51. ncbi Interferon-gamma gene+874T-A polymorphism is associated with tuberculosis and gamma interferon response
    Nilgun Sallakci
    Akdeniz University Health Sciences Research Centre, Akdeniz University, Faculty of Medicine, Antalya, Turkey
    Tuberculosis (Edinb) 87:225-30. 2007
    ..Our data suggest that similar to various Caucasian populations, in a Turkish population the IFN-gamma+874 T-A polymorphism is also associated with tuberculosis disease and affects the magnitude of the IFN-gamma response...
  52. ncbi Tuberculous meningitis: protracted course and clinical response to interferon-gamma
    J Brian S Coulter
    Royal Liverpool Children s NHS Trust, Liverpool, UK
    Lancet Infect Dis 7:225-32. 2007
    ..The response to interferon-gamma might have been secondary to downregulation of certain cytokine and chemokine genes...
  53. pmc Decreased serum granulysin levels in childhood tuberculosis which reverse after therapy
    Diana Di Liberto
    Dipartimento di Biopatologia e Metodologie Biomediche, Universita di Palermo, Corso Tukory 211, 90134 Palermo, Italy
    Tuberculosis (Edinb) 87:322-8. 2007
    ..We propose that serum granulysin levels may provide a marker of disease activity in childhood TB and might be useful for monitoring improvement after chemotherapy...
  54. ncbi Tuberculous meningovasculitis
    Dimitri Renard
    Department of Neurology, CHU Montpellier, Hopital Gui de Chauliac, Montpellier, France
    Neurology 68:1745. 2007
  55. ncbi Drug susceptibility profiling of tuberculous meningitis
    S Nagarathna
    Department of Neuromicrobiology, National Institute of Mental Health and Neurosciences NIMHANS, Bangalore, India
    Int J Tuberc Lung Dis 12:105-7. 2008
    ..These data suggest that multidrug resistance in tuberculous meningitis is not yet a serious problem. However, a periodic review is required to ascertain the global incidence of drug-resistant tuberculous meningitis...
  56. ncbi [Tuberculosis meningitis in adults: 5 cases]
    Anna Capelli
    Divisione Malattie Infettive e Tropicali Policlinico IRCCS Policlinico San Matteo, Pavia, Italy
    Infez Med 15:40-6. 2007
    ....
  57. ncbi Factors affecting the outcome of neuroendoscopy in patients with tuberculous meningitis hydrocephalus: a preliminary study
    Deepak Kumar Jha
    Department of Neurosurgery, St Stephens Hospital, Tishazari, Delhi 110054, India
    Surg Neurol 68:35-41; discussion 41-2. 2007
    ..In recent years, ETV has been found to be effective in patients with TBMH; however, its precise selection criteria are yet to be established. We carried out this study to identify the factors affecting the outcome of ETV in TBMH...
  58. ncbi Chest computerized tomography scan findings in 74 children with tuberculous meningitis in southeastern Turkey
    Ahmet Yaramiş
    Department of Pediatrics, Dicle University Faculty of Medicine, Diyarbakir, Turkey
    Turk J Pediatr 49:365-9. 2007
    ..Chest computerized tomography scan helps establish the diagnosis of TBM when chest radiography is normal or inconclusive, and it is useful in assessing children with suspected TBM...
  59. ncbi Tuberculous meningitis presenting with unusually severe hyponatremia
    Bernardino Roca
    Department of Medicine, Hospital General of Castellon, University of Valencia, Spain
    Mt Sinai J Med 73:1029-30. 2006
    ..The hyponatremia was probably due to the syndrome of inappropriate antidiuretic hormone secretion, and resolved after instituting water restriction and antituberculous medication...
  60. ncbi Absence of an association between Mycobacterium tuberculosis genotype and clinical features in children with tuberculous meningitis
    Freda Maree
    Desmond Tutu TB Centre, Department of Pediatrics and Child Health, Stellenbosch University, Stellenbosch, South Africa
    Pediatr Infect Dis J 26:13-8. 2007
    ..We investigated mycobacterial genotypic diversity in children with TBM and analyzed the relationship among genotype, clinical presentation and outcome...
  61. ncbi [Tuberculoma complicating tuberculous meningitis: description of one paediatric case]
    C Ruggeri
    U O di Clinica Pediatrica, Dipartimento di Scienze Pediatriche Mediche e Chirurgiche, Universita degli Studi di Messina, Messina
    Minerva Pediatr 57:329-32. 2005
    ..We underline how such an event is possible, the need for early neuroradiological evaluation and its favourable course, maintaining adequate antitubercular therapy associated with steroid therapy...
  62. ncbi The therapeutic paradox in the diagnosis of tuberculous meningitis
    Juan Carlos Garcia-Monco
    Servicio de Neurologia, Hospital de Galdacano, 48960 Galdacano, Vizcaya, Spain
    Neurology 65:1991-2. 2005
  63. ncbi Factors influencing the presentation and outcome of tuberculous meningitis in childhood
    F S Faella
    Department of Emergency and Infectious Diseases, D Cotugno Hospital, Naples, Italy
    In Vivo 20:187-91. 2006
    ..Tuberculosis (TB) is an important cause of morbidity and mortality worldwide. Here, we describe our experience of childhood tuberculous meningitis (TBM), focusing on factors influencing presentation and outcome...
  64. ncbi Multidrug-resistant tuberculous meningitis in children in Durban, South Africa
    Nesri Padayatchi
    CAPRISA, Nelson Mandela School of Medicine, University of KwaZulu Natal, Durban, South Africa
    Pediatr Infect Dis J 25:147-50. 2006
    ..The diagnosis of TBM in children is difficult because signs and symptoms are vague. Information about drug resistant TB in children is scarce, and there is no published information on drug resistant TBM in children...
  65. pmc Occurrence of overlooked zoonotic tuberculosis: detection of Mycobacterium bovis in human cerebrospinal fluid
    N P Shah
    All India Institute of Medical Sciences, Department of Biotechnology, Ansari Nagar, New Delhi 110029, India
    J Clin Microbiol 44:1352-8. 2006
    ..4%). Determination to the species level is important from the viewpoint of determining the prevalence of these mycobacteria in a community and would influence strategies currently adopted for the prevention of tuberculosis...
  66. ncbi [Multiple brain tuberculomas]
    Tomasz Piorunek
    Katedra i Klinika Ftyzjopneumonologii AM im K Marcinkowskiego w Poznaniu
    Pol Arch Med Wewn 114:1220-5. 2005
    ..Basing on the described case, current possibilities of tuberculoma diagnostic difficulties, caused by unspecific clinical manifestation and atypical radiological lesions, was drawn...
  67. ncbi Phenotypical and functional analysis of memory and effector human CD8 T cells specific for mycobacterial antigens
    Nadia Caccamo
    Dipartimento di Biopatologia e Metodologie Biomediche, Universita di Palermo, Palermo, Italy
    J Immunol 177:1780-5. 2006
    ..Our study represents the first characterization of Ag-specific memory and effector CD8 T cells during TB and may help to understand the type of immune response that vaccine candidates should stimulate to achieve protection...
  68. ncbi Comment on "Thwaites et al., 2005, The influence of HIV infection on clinical presentation, response to treatment, and outcome in adults with Tuberculous meningitis" J Infect Dis. 2005 Dec 15;192(12):2134-41
    Devesh J Dhasmana
    J Infect 54:205; author reply 206. 2007
  69. ncbi Rapid diagnosis of tuberculous meningitis: a comparative evaluation of in-house PCR assays involving three mycobacterial DNA sequences, IS6110, MPB-64 and 65 kDa antigen
    Wasiulla Rafi
    Department of Neuromicrobiology, National Institute of Mental Health and Neurosciences, Bangalore, 560 029, India
    J Neurol Sci 252:163-8. 2007
    ....
  70. pmc A case of oculomotor nerve palsy and choroidal tuberculous granuloma associated with tuberculous meningoencephalitis
    Sunghyuk Moon
    Department of Ophthalmology, Yeungnam University College of Medicine, Daegu, Korea
    Korean J Ophthalmol 22:201-4. 2008
    ....
  71. ncbi [A case of refractory tuberculous meningitis markedly improved by intrathecal administration of isoniazid (INH)]
    Teruyuki Takahashi
    Department of Neurology, Nihon University Nerima Hikarigaoka Hospital
    Rinsho Shinkeigaku 43:20-5. 2003
    ..Our findings suggested that intrathecal administration of INH was useful for refractory tuberculous meningitis...
  72. ncbi Tuberculous meningitis in adults: review of 61 cases
    P N Sutlas
    Dept of Neurology, Bakirkoy Research and Training Hospital for Psychiatric and Neurological Diseases, Istanbul, Turkey
    Infection 31:387-91. 2003
    ..The objective of this study was to assess the clinical, laboratory, radiological and prognostic features of tuberculous meningitis (TBM) in immuncompetent adult patients...
  73. ncbi Peripartum tuberculosis as a form of immunorestitution disease
    V C C Cheng
    Division of Infectious Diseases, Center of Infection, Queen Mary Hospital, The University of Hong Kong, University Pathology Building, Hong Kong
    Eur J Clin Microbiol Infect Dis 22:313-7. 2003
    ..Despite therapy, 11 (38%) patients died and 4 (13.8%) had residual functional deficits. Peripartum tuberculosis is an important differential diagnosis of postpartum fever (of unknown origin) without localized signs...
  74. ncbi Long-term follow up of childhood tuberculous meningitis
    J Schoeman
    Department of Paediatrics and Child Health, Tygerberg Children s Hospital, South Africa
    Dev Med Child Neurol 44:522-6. 2002
    ..A high index of suspicion of TBM in high tuberculosis incidence communities will help prevent the morbidity documented in this study...
  75. ncbi [How I investigate...difficult cases of tuberculous meningitis]
    R Lemaire
    , CHR Citadelle,
    Rev Med Liege 56:181-5. 2001
    ..It, unfortunately, remains difficult to make the diagnosis of tuberculous meningitis even though this pathology can have extremely deleterious consequences...
  76. ncbi Tuberculosis-any new insights?
    C Ruef
    Infection 31:373. 2003
  77. ncbi Familial outbreak of disseminated multidrug-resistant tuberculosis and meningitis
    M Sofia
    Department of Respiratory Disease, University of Naples Federico II, Italy
    Int J Tuberc Lung Dis 5:551-8. 2001
    ..It also reinforces the concept that genetic susceptibility to M. tuberculosis may be an important factor in the clinical presentation and outcome of MDR-TB...
  78. ncbi [Tuberculous meningoencephalitis: a case report]
    L Kepa
    , Katedrze i Klinice Ftizjopneumonologii Slaskiej Akademii Medycznej, Bytomiu
    Pol Merkur Lekarski 11:173-4. 2001
    ..The therapy of tuberculous meningoencephalitis and the problem of potential Mycobacterium tuberculosis resistance to antituberculous drugs used up to the present are also discussed...
  79. ncbi Tuberculous radiculomyelitis: review and presentation of five patients
    A Moghtaderi
    Neurology Department, Zahedan University of Medical Sciences, Zahedan, Iran
    Int J Tuberc Lung Dis 7:1186-90. 2003
    ..The southeast region of Iran is an endemic area for tuberculosis. Tuberculous radiculomyelitis (TBRM) was considered a rare form of parenchymal neurotuberculosis...
  80. ncbi Diagnostic criteria for Tuberculous Meningitis
    Rachna Seth
    Department of Pediatrics, All India Institute of Medical Sciences, New Delhi
    Indian J Pediatr 69:299-303. 2002
    ..The diagnosis is based on clinical evaluation since the bacteriological diagnosis takes time and has a low yield. This study attempts to validate these criteria in children with TBM...
  81. ncbi Clinical relevance of hydrocephalus as a presenting feature of tuberculous meningitis
    K H Chan
    Division of Neurology, University Department of Medicine, University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong
    QJM 96:643-8. 2003
    ..Hydrocephalus is a common complication of tuberculous meningitis (TBM)...
  82. ncbi Intradural, eextramedullary tuberculoma of the spinal cord as a complication of tuberculous meningitis
    P Skendros
    Dept of Internal Medicine, Hospital of Infectious Diseases, Grigoriou Lampraki 13 str, GR 54638 Thessaloniki, Greece
    Infection 31:115-7. 2003
    ..Despite the anti-TB treatment and the surgical resection, intramedullary spreading occurred. Finally, a favorable response was achieved by prolongation of treatment accompanied by the administration of ofloxacin and cycloserine...
  83. ncbi [Epidemiology of paediatric tuberculosis today]
    Lucina Titone
    Istituto di Patologia Infettiva e Virologia, Università degli Studi di Paleermo, Italia
    Infez Med 11:127-32. 2003
    ..These data suggest that it would be opportune to re-evaluate current treatment of childhood tuberculosis, encouraging active and integrated cooperation between epidemiologists, infectious disease specialists and paediatricians...
  84. ncbi [Central nervous tuberculosis in patients non-VIH: seven case reports]
    K Mazodier
    Service de Medecine Interne, CHU de la Conception, 147, boulevard Baille, 13385 cedex 05, Marseille, France
    Rev Med Interne 24:78-85. 2003
    ..Tuberculosis involving the central nervous system (CNS) is rarely observed in non immuno-compromised hosts. We report herin the various clinical, biological and radiological manifestations observed in 7 patients with CNS tuberculosis...
  85. ncbi Miliary lung lesions and multiple intracranial tumors in a 26-year-old woman
    Shih Feng Liu
    Division of Chest Medicine, Department of Internal Medicine, Chang Gung Memorial Hospital, Kaohsiung Hsien, Taiwan, ROC
    Respiration 69:471-2. 2002
  86. ncbi Tuberculous meningitis in infancy
    Yu Ren Tung
    Department of Pediatrics, Chang Gung Memorial Hospital, Niao Sung, Kaohsiung County, Taiwan
    Pediatr Neurol 27:262-6. 2002
    ....
  87. ncbi Adjunctive thalidomide therapy for childhood tuberculous meningitis: results of a randomized study
    Johan F Schoeman
    Department of Pediatrics and Child Health, Tygerberg Children s Hospital, Faculty of Health Sciences, University of Stellenbosch, Tygerberg, South Africa
    J Child Neurol 19:250-7. 2004
    ..8 versus mean IQ control group 67.5; P = .16). These results do not support the use of adjunctive high-dose thalidomide therapy in the treatment of tuberculous meningitis...
  88. ncbi Prognosis of tuberculous meningitis in adults in the era of modern antituberculous chemotherapy
    Jann Tay Wang
    Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan, ROC
    J Microbiol Immunol Infect 35:215-22. 2002
    ..In addition, more advanced clinical staging evaluated at 30 days after the start of antituberculous chemotherapy and a positive cerebrospinal fluid culture for M. tuberculosis were associated with a poor prognosis...
  89. ncbi Endoscopic lamina terminalis fenestration for treatment of hydrocephalus due to tuberculous meningitis. Case illustration
    Naoyuki Nakao
    Department of Neurological Surgery, Wakayama Medical University, Wakayama, Japan
    J Neurosurg 99:187. 2003
  90. ncbi Tuberculous meningitis in a country with a low incidence of tuberculosis: still a serious disease and a diagnostic challenge
    Christine Bidstrup
    Department of Infectious Diseases, Rigshospitalet, Copenhagen, Denmark
    Scand J Infect Dis 34:811-4. 2002
    ..The findings indicate that Tm is a rare but still serious disease, and one that is associated with high mortality and morbidity...
  91. ncbi Rapid molecular diagnosis of tuberculous meningitis using the Gen-probe Amplified Mycobacterium Tuberculosis direct test in a large Canadian public health laboratory
    P Chedore
    Clinical and Environmental Microbiology, Laboratories Branch, Ministry of Health and Long Term Care, Etobicoke, Ontario, Canada
    Int J Tuberc Lung Dis 6:913-9. 2002
    ..Patient data from culture-confirmed cases of tuberculous meningitis (TBM) were also analysed...
  92. ncbi Tuberculous meningitis and miliary tuberculosis in young children
    F van den Bos
    Utrecht University Medical Center, Utrecht, The Netherlands
    Trop Med Int Health 9:309-13. 2004
    ..To document the clinical and diagnostic features of tuberculous meningitis (TBM) in young children with and without concomitant miliary tuberculosis (TB)...
  93. pmc A rare site for tuberculosis
    Amitabh Monga
    Department of Internal Medicine, Sitaram Bhartia Institute of Science and Research, New Delhi, India
    CMAJ 167:1149-50. 2002
  94. ncbi [Neuroradiologic manifestations of central nervous system tuberculosis in 122 adults]
    B Kilani
    Service des Maladies Infectieuses, Hopital La Rabta, 1007 Jebbari, Tunis, Tunisie
    Rev Med Interne 24:86-96. 2003
    ..Central nervous system (CNS) tuberculosis remains a public health problem, particularly in developing countries. The aim of this study is to characterize neuroradiologic findings of various intracranial lesions...
  95. ncbi Multidrug-resistant tuberculosis meningitis: clinical problems and concentrations of second-line antituberculous medications
    J P DeVincenzo
    Division of Infectious Diseases, University of Tennessee, Memphis, USA
    Ann Pharmacother 33:1184-8. 1999
    ..corrected] To describe a case of culture-proven multidrug-resistant tuberculous (MDR-TB) meningitis, in which the patient survived long enough for clinicians to adjust antituberculous therapy to second-line therapeutic agents...
  96. ncbi Etiological profile of presumptive optic neuritis in China
    Xiaojun Zhang
    Department of Neurology, Beijing Tongren Hospital, Capital Medical University, Beijing, China
    J Clin Neurosci 15:1346-9. 2008
    ..Despite minor differences regarding the causes and prognosis, the etiology of ON in our population is similar to that reported in Western countries...
  97. ncbi [Meningeal tuberculosis and renal lithiasis. A case report]
    A Benabdellah
    Unite de Reanimation, Service des Maladies Infectieuses, CHU d Oran, Oran, Algerie
    Ann Urol (Paris) 36:26-8. 2002
    ..Koch's bacillus is found in the urine. The evolution under medical treatment was excellent. The urinary lithiasis has hided tuberculosis and the discovery of the disease was late...
  98. ncbi [Isoniazid-induced hepatic failure. Report of a case]
    R M Pereira
    Departamento de Pediatria da Faculdade de Ciências Médicas, Universidade Estadual de Campinas
    Arq Gastroenterol 37:72-5. 2000
    ..This paper intends to relate a case of a 5-month-old patient who had lungs' and meningeal tuberculosis and who developed toxic hepatitis accomplished by hepatic failure while he was being treated with ..
  99. ncbi Demographic characteristics of patients with extrapulmonary tuberculosis in Germany
    M Forssbohm
    Public Health Centre, Wiesbaden, Germany
    Eur Respir J 31:99-105. 2008
    ..Children were particularly prone to the development of lymphatic and meningeal tuberculosis, whereas the likelihood of genitourinary tuberculosis increased with increasing age...
  100. ncbi [Epidemiology of bacterial meningitis in France in 2002]
    Anne Perrocheau
    Departement des Maladies Infectieuses, Institut de Veille Sanitaire, 94415 Saint Maurice Cedex
    Rev Prat 54:945-50. 2004
    ..The impact of preventive measures on the incidence of Listeria meningitis and H. influenzae b meningitis has been clearly demonstrated through the dramatic decrease of meningitis due to these microorganisms...
  101. ncbi Pattern of presentation of tuberculosis and the hospital prevalence of tuberculosis and HIVco-infection in University College Hospital, Ibadan: a review of five years (1998 - 2002)
    O M Ige
    Pulmonary Unit, Department of Medicine, University College Hospital, Ibadan, Nigeria
    Afr J Med Med Sci 34:329-33. 2005
    ..Only 180 out of the 640 cases of TB were confirmed as HIV positive giving a seroprevalence rate of 28.12%. The annual distribution of TB/HIV co-infection showed a rising trend from 26 cases in 1998 to 42 cases in 2002...

Research Grants8

  1. Intercellular trafficking of labeled aminoglycosides in living hair cells
    Dale Warren Hailey; Fiscal Year: 2013
    ..I propose to characterize the intracellular compartments transited by labeled neomycin, and developing tools to perturb intracellular trafficking pathways to identify key trafficking events that underlie aminoglycoside toxicity. ..
  2. Structural Topology of a Small Multidrug Resistant Efflux Pump
    Nathaniel J Traaseth; Fiscal Year: 2012
    ..The long-term goal of this project is to predict how drug binding might be altered in mutated strains of bacteria, so as to design new and better antibiotics in the event of multidrug resistance. ..
  3. Training in Host-pathogens interactions
    David M Mosser; Fiscal Year: 2013
    ..This program includes developing strategies to protect humans and animals to improve the quality of people's lives. ..
  4. M Tuberculosis CTL Epitopes: Vaccine Design/Evaluation
    Elizabeth Mellins; Fiscal Year: 2007
    ..For TB, which takes years to decades to develop after infection with Mtb, immune correlates with protection are an attractive, and perhaps essential, supplement to efficacy trials. ..
  5. QSTAR Elite Quadrupole-o-TOF LC/MS/MS System
    Bradford Gibson; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  6. Toll-like Receptors and the Innate Immune Response
    THOMAS HAWN; Fiscal Year: 2003
    ..tuberculosis and L. major will reveal novel insights about innate immunity and infectious diseases that will have implications for vaccine development. ..
  7. TLR5 and Pulmonary Innate Immunity
    THOMAS HAWN; Fiscal Year: 2009
    ..The immunogenetic models derived from these studies will illuminate the molecular basis of why individuals have different susceptibility to flagellated bacterial infections and hopefully culminate in novel insights for future therapies. ..
  8. Fluoroquinolone Resistance in M. Tuberculosis
    Timothy R Sterling; Fiscal Year: 2010
    ..tuberculosis would clarify whether fluoroquinolones are indeed a viable option for the first-line treatment of tuberculosis, and how best to preserve their usefulness against tuberculosis. ..