syphilis

Summary

Summary: A contagious venereal disease caused by the spirochete TREPONEMA PALLIDUM.

Top Publications

  1. ncbi Syphilis: reemergence of an old adversary
    Jennifer R Chao
    Doheny Eye Institute and the Department of Ophthalmology, Keck School of Medicine of the University of Southern California, Los Angeles, California 90033, USA
    Ophthalmology 113:2074-9. 2006
  2. ncbi Syphilis and HIV seroconversion among a 12-month prospective cohort of men who have sex with men in Shenyang, China
    Jun Jie Xu
    Hospital of China Medical University, Shenyang, China
    Sex Transm Dis 37:432-9. 2010
  3. ncbi The efficacy of clinic-based interventions aimed at increasing screening for bacterial sexually transmitted infections among men who have sex with men: a systematic review
    Huachun Zou
    Sexual Health Unit, School of Population Health, University of Melbourne, Melbourne, Vic, Australia
    Sex Transm Dis 39:382-7. 2012
  4. ncbi Effectiveness of interventions to improve screening for syphilis in pregnancy: a systematic review and meta-analysis
    Sarah Hawkes
    Institute of Global Health, University College London, London, UK
    Lancet Infect Dis 11:684-91. 2011
  5. ncbi Meta-analysis: prevalence of HIV infection and syphilis among MSM in China
    L Gao
    Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking UnionMedical College, Beijing, PR China
    Sex Transm Infect 85:354-8. 2009
  6. ncbi Trends in prevalence of HIV, syphilis, hepatitis C, hepatitis B, and sexual risk behavior among men who have sex with men. Results of 3 consecutive respondent-driven sampling surveys in Beijing, 2004 through 2006
    Xiaoyan Ma
    Beijing Centers for Disease Control and Prevention, Beijing, China
    J Acquir Immune Defic Syndr 45:581-7. 2007
  7. pmc Bisexual behavior and infection with HIV and syphilis among men who have sex with men along the east coast of China
    Meizhen Liao
    Shandong Center for Disease Control and Prevention, Jinan, Shandong Province, PR China
    AIDS Patient Care STDS 25:683-91. 2011
  8. ncbi Reemergence of the HIV epidemic among men who have sex with men in North America, Western Europe, and Australia, 1996-2005
    Patrick S Sullivan
    Department of Epidemiology, Emory University, Rollins School of Public Health, Atlanta, GA 30322, USA
    Ann Epidemiol 19:423-31. 2009
  9. ncbi Syphilis in China: results of a national surveillance programme
    Zhi Qiang Chen
    National Center for STD Control, Chinese Academy of Medical Sciences and Peking Union Medical College Institute of Dermatology, 12 Jiangwangmiao Street, Nanjing 210042, China
    Lancet 369:132-8. 2007
  10. pmc Prospective, multi-centre clinic-based evaluation of four rapid diagnostic tests for syphilis
    D Mabey
    London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Sex Transm Infect 82:v13-6. 2006

Detail Information

Publications331 found, 100 shown here

  1. ncbi Syphilis: reemergence of an old adversary
    Jennifer R Chao
    Doheny Eye Institute and the Department of Ophthalmology, Keck School of Medicine of the University of Southern California, Los Angeles, California 90033, USA
    Ophthalmology 113:2074-9. 2006
    To describe the clinical findings in 4 patients with ocular syphilis and to provide a review of the recent rise in syphilis cases in the United States, along with a brief description of current diagnosis and treatment guidelines.
  2. ncbi Syphilis and HIV seroconversion among a 12-month prospective cohort of men who have sex with men in Shenyang, China
    Jun Jie Xu
    Hospital of China Medical University, Shenyang, China
    Sex Transm Dis 37:432-9. 2010
    Cross-sectional studies have found a high prevalence of syphilis and HIV infection among men who have sex with men (MSM) in China.
  3. ncbi The efficacy of clinic-based interventions aimed at increasing screening for bacterial sexually transmitted infections among men who have sex with men: a systematic review
    Huachun Zou
    Sexual Health Unit, School of Population Health, University of Melbourne, Melbourne, Vic, Australia
    Sex Transm Dis 39:382-7. 2012
    ..We undertook a systematic review to identify clinic-based strategies for increasing screening and detection of bacterial STIs among MSM...
  4. ncbi Effectiveness of interventions to improve screening for syphilis in pregnancy: a systematic review and meta-analysis
    Sarah Hawkes
    Institute of Global Health, University College London, London, UK
    Lancet Infect Dis 11:684-91. 2011
    About 2·1 million pregnant women have active syphilis every year. Without screening and treatment, 69% of these women will have an adverse outcome of pregnancy...
  5. ncbi Meta-analysis: prevalence of HIV infection and syphilis among MSM in China
    L Gao
    Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking UnionMedical College, Beijing, PR China
    Sex Transm Infect 85:354-8. 2009
    ..The aim is to systematically review the published studies and summarise the estimates of HIV prevalence among MSM in China...
  6. ncbi Trends in prevalence of HIV, syphilis, hepatitis C, hepatitis B, and sexual risk behavior among men who have sex with men. Results of 3 consecutive respondent-driven sampling surveys in Beijing, 2004 through 2006
    Xiaoyan Ma
    Beijing Centers for Disease Control and Prevention, Beijing, China
    J Acquir Immune Defic Syndr 45:581-7. 2007
    ..We report on 3 consecutive cross-sectional surveys measuring the prevalence of HIV, other infectious diseases, and related risk behavior among MSM in Beijing in 2004, 2005, and 2006...
  7. pmc Bisexual behavior and infection with HIV and syphilis among men who have sex with men along the east coast of China
    Meizhen Liao
    Shandong Center for Disease Control and Prevention, Jinan, Shandong Province, PR China
    AIDS Patient Care STDS 25:683-91. 2011
    This study examined the correlates of bisexual behavior and infection with HIV/syphilis among men who have sex with men only (MSM-only) and those who have sex with both men and women (MSMW) in Shandong, China...
  8. ncbi Reemergence of the HIV epidemic among men who have sex with men in North America, Western Europe, and Australia, 1996-2005
    Patrick S Sullivan
    Department of Epidemiology, Emory University, Rollins School of Public Health, Atlanta, GA 30322, USA
    Ann Epidemiol 19:423-31. 2009
    ....
  9. ncbi Syphilis in China: results of a national surveillance programme
    Zhi Qiang Chen
    National Center for STD Control, Chinese Academy of Medical Sciences and Peking Union Medical College Institute of Dermatology, 12 Jiangwangmiao Street, Nanjing 210042, China
    Lancet 369:132-8. 2007
    After a massive syphilis epidemic in the first half of the 20th century, China was able to eliminate this infection for 20 years (1960-80)...
  10. pmc Prospective, multi-centre clinic-based evaluation of four rapid diagnostic tests for syphilis
    D Mabey
    London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Sex Transm Infect 82:v13-6. 2006
    To evaluate prospectively four rapid, point-of-care serological tests for syphilis in prenatal or high risk populations in four countries.
  11. pmc TP0326, a Treponema pallidum β-barrel assembly machinery A (BamA) orthologue and rare outer membrane protein
    Daniel C Desrosiers
    Department of Medicine, University of Connecticut Health Center, Farmington, CT 06040, USA
    Mol Microbiol 80:1496-515. 2011
    ..mount a vigorous antibody response to both POTRA and β-barrel portions of TP0326, whereas humans with secondary syphilis respond predominantly to POTRA...
  12. pmc Prevalence of HIV and STIs and associated risk factors among female sex workers in Guangdong Province, China
    Yan Li
    Institute of HIV AIDS Control and Prevention, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, China
    J Acquir Immune Defic Syndr 53:S48-53. 2010
    ..To assess the prevalence of HIV and sexually transmitted infections (STIs) and associated factors among female sex workers (FSWs) in Guangdong, China...
  13. ncbi Relationship between syphilis and HIV infections among men who have sex with men in Beijing, China
    Yuhua Ruan
    State Key Laboratory for Infectious Disease Prevention and Control, and National Center for AIDS STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China
    Sex Transm Dis 34:592-7. 2007
    ..Little is known about risk of HIV and other STDs among men who have sex with men (MSM) in China...
  14. pmc Risk factors for syphilis and prevalence of HIV, hepatitis B and C among men who have sex with men in Beijing, China: implications for HIV prevention
    Yuhua Ruan
    Epidemiology and Biostatistics Branch, Division of Virology and Immunology, State Key Laboratory for Infectious Disease Prevention and Control, NCAIDS, Chinese CDC, Beijing 100050, People s Republic of China
    AIDS Behav 13:663-70. 2009
    To examine the correlates for syphilis and the prevalence for HIV, hepatitis B, hepatitis C among men-who-have-sex-with-men (MSM) in Beijing, China. A total of 541 MSM was recruited using peer-referral, community outreach, and Internet...
  15. ncbi Syphilis in pregnancy in Tanzania. II. The effectiveness of antenatal syphilis screening and single-dose benzathine penicillin treatment for the prevention of adverse pregnancy outcomes
    Deborah Watson-Jones
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
    J Infect Dis 186:948-57. 2002
    Treatment for maternal syphilis with single-dose benzathine penicillin (2.4 million units intramuscularly) is being implemented in many parts of sub-Saharan Africa...
  16. ncbi Novel Treponema pallidum serologic tests: a paradigm shift in syphilis screening for the 21st century
    Arlene C Sena
    Department of Medicine, University of North Carolina at Chapel Hill, NC 27599, USA
    Clin Infect Dis 51:700-8. 2010
    ..Many new diagnostic methods for syphilis have been developed, using specific treponemal antigens and novel formats, including rapid point-of-care tests, ..
  17. ncbi Increasing prevalence of HIV and syphilis but decreasing rate of self-reported unprotected anal intercourse among men who had sex with men in Harbin, China: results of five consecutive surveys from 2006 to 2010
    Kaili Wang
    Harbin Medical University, Harbin, China, Heilongjiang Provincial Center for Disease Control and Prevention, Harbin, China
    Int J Epidemiol 41:423-32. 2012
    To monitor the prevalence of HIV and syphilis as well as behaviours, a sentinel site for men who have sex with men was established in Harbin in 2002...
  18. ncbi Rapidly increasing prevalence of HIV and syphilis and HIV-1 subtype characterization among men who have sex with men in Jiangsu, China
    HongXiong Guo
    Jiangsu Center for Disease Control and Prevention, Nanjing, China
    Sex Transm Dis 36:120-5. 2009
    To investigate the prevalence of HIV, hepatitis B (HBV), hepatitis C (HCV), and syphilis among men who have sex with men (MSM) in 2 cities of Jiangsu, China, and to characterize the HIV-1 subtypes prevalent among this population.
  19. ncbi First report on sexually transmitted infections among trans (male to female transvestites, transsexuals, or transgender) and male sex workers in Argentina: high HIV, HPV, HBV, and syphilis prevalence
    Maria Sol Dos Ramos Farias
    Centro Nacional de Referencia para el SIDA CNRS, Departamento de Microbiologia, Parasitologia e Inmunologia, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155, Piso 11, C1121ABG, Buenos Aires, Argentina
    Int J Infect Dis 15:e635-40. 2011
    ..Human papillomavirus (HPV) and Chlamydia trachomatis infections were tested among TSW...
  20. ncbi HIV and syphilis prevalence and associated factors among young men who have sex with men in 4 cities in China
    Suo Wei
    School of Public Health, Anhui Medical University, 69 Meishan Road, 230032, Hefei, Anhui Province, People s Republic of China
    AIDS Behav 17:1151-8. 2013
    To know the status of HIV and syphilis infection, and the correlates for HIV and syphilis prevalence among YMSM in China...
  21. ncbi HIV and syphilis prevalence and associated risk factors among fishing communities of Lake Victoria, Uganda
    Gershim Asiki
    Medical Research Council MRC Uganda Virus Research Institute UVRI Uganda Research Unit on AIDS, Entebbe, Uganda
    Sex Transm Infect 87:511-5. 2011
    ..However, accurate data are scarce. The authors determined HIV and syphilis prevalence and associated risk factors in a fishing population of Lake Victoria in Uganda.
  22. pmc Genetic diversity in Treponema pallidum: implications for pathogenesis, evolution and molecular diagnostics of syphilis and yaws
    David Smajs
    Department of Biology, Faculty of Medicine, Masaryk University, Kamenice 5, Building A6, 625 00 Brno, Czech Republic
    Infect Genet Evol 12:191-202. 2012
    Pathogenic uncultivable treponemes, similar to syphilis-causing Treponema pallidum subspecies pallidum, include T. pallidum ssp. pertenue, T. pallidum ssp. endemicum and Treponema carateum, which cause yaws, bejel and pinta, respectively...
  23. pmc Quantitative analysis of tpr gene expression in Treponema pallidum isolates: Differences among isolates and correlation with T-cell responsiveness in experimental syphilis
    Lorenzo Giacani
    Department of Medicine, Box 359779, Harborview Medical Center, 325 Ninth Ave, Seattle, WA 98104 2499, USA
    Infect Immun 75:104-12. 2007
    ..limited to date, and yet the expression of members of this gene family is likely relevant to the pathogenesis of syphilis. Recently, immunological studies and semiquantitative mRNA analysis led to the hypothesis of the modulation of ..
  24. ncbi Syphilis in pregnancy in Tanzania. I. Impact of maternal syphilis on outcome of pregnancy
    Deborah Watson-Jones
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
    J Infect Dis 186:940-7. 2002
    To measure the impact of maternal syphilis on pregnancy outcome in the Mwanza Region of Tanzania, 380 previously unscreened pregnant women were recruited into a retrospective cohort at delivery and tested for syphilis...
  25. pmc HIV and syphilis co-infection increasing among men who have sex with men in China: a systematic review and meta-analysis
    Eric P F Chow
    The Kirby Institute for Infection and Immunity in Society, Faculty of Medicine, University of New South Wales, Sydney, Australia
    PLoS ONE 6:e22768. 2011
    This study aims to estimate the magnitude and changing trends of HIV, syphilis and HIV-syphilis co-infections among men who have sex with men (MSM) in China during 2003-2008 through a systematic review of published literature.
  26. pmc Whole genome sequences of three Treponema pallidum ssp. pertenue strains: yaws and syphilis treponemes differ in less than 0.2% of the genome sequence
    Darina Čejková
    Department of Biology, Masaryk University, Brno, Czech Republic
    PLoS Negl Trop Dis 6:e1471. 2012
    The yaws treponemes, Treponema pallidum ssp. pertenue (TPE) strains, are closely related to syphilis causing strains of Treponema pallidum ssp. pallidum (TPA)...
  27. pmc Surface immunolabeling and consensus computational framework to identify candidate rare outer membrane proteins of Treponema pallidum
    David L Cox
    Division of STD Prevention, Laboratory Reference and Research Branch, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Infect Immun 78:5178-94. 2010
    ..To better understand the basis for the syphilis spirochete's "stealth pathogenicity," we used a dual-label, 3-step amplified assay in which treponemes ..
  28. ncbi Prevalence and correlates of HIV and syphilis infections among men who have sex with men in seven provinces in China with historically low HIV prevalence
    Yan Xiao
    National Center for AIDS STD Control and Prevention, Beijing, People s Republic of China
    J Acquir Immune Defic Syndr 53:S66-73. 2010
    To assess HIV and syphilis infection among men who have sex with men (MSM) in Chinese regions with historically low HIV prevalence.
  29. ncbi Prevalence and correlates of HIV and syphilis infections among men who have sex with men in Chongqing Municipality, China
    Yan Xiao
    National Center for AIDS STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 100050, People s Republic of China
    Sex Transm Dis 36:647-56. 2009
    To examine the prevalence and correlates of HIV/syphilis infections and sexually transmitted diseases (STDs) among men who have sex with men (MSM) in Chongqing, China.
  30. ncbi Possible increase in HIV and syphilis prevalence among men who have sex with men in Guangzhou, China: results from a respondent-driven sampling survey
    Fei Zhong
    Guangzhou Municipal Center for Disease Control and Prevention, 510080, Guangzhou, China
    AIDS Behav 15:1058-66. 2011
    ..Three hundred seventy-nine eligible participants were recruited. The adjusted prevalence of HIV and current syphilis infection are 5.2% and 17.5% respectively. 60.3% have unprotected anal sex in the past 6 months...
  31. ncbi Incidence of HIV-1, syphilis, hepatitis B, and hepatitis C virus infections and predictors associated with retention in a 12-month follow-up study among men who have sex with men in Beijing, China
    Yuhua Ruan
    State Key Laboratory for Infectious Disease Prevention and Control, and National Center for AIDS sexually transmitted disease Control and Prevention, Chinese Center for Disease Control and Prevention China CDC, Beijing, P R China
    J Acquir Immune Defic Syndr 52:604-10. 2009
    To investigate the incidence of HIV-1, syphilis, hepatitis B virus (HBV), and hepatitis C virus (HCV) infections and predictors associated with retention in a 12-month follow-up study among men who have sex with men (MSM) in Beijing, China...
  32. ncbi Syphilis screening among female sex workers in Bangalore, India: comparison of point-of-care testing and traditional serological approaches
    Sharmistha Mishra
    Division of Infectious Diseases, University of Toronto, Toronto, Canada
    Sex Transm Infect 86:193-8. 2010
    We undertook a prospective evaluation of the Qualpro Syphicheck-WB rapid syphilis test to measure its diagnostic performance and utility as a point-of-care (POC) screening test among female sex workers (FSWs) in Bangalore, India.
  33. pmc Evaluation of macrolide resistance and enhanced molecular typing of Treponema pallidum in patients with syphilis in Taiwan: a prospective multicenter study
    Hsiu Wu
    Centers for Disease Control, Taipei, Taiwan
    J Clin Microbiol 50:2299-304. 2012
    ..pallidum using a PCR assay using clinical specimens from patients with syphilis at six major designated hospitals for HIV care in Taiwan. The T...
  34. ncbi Men who have sex with men have a 140-fold higher risk for newly diagnosed HIV and syphilis compared with heterosexual men in New York City
    Preeti Pathela
    Bureau of Sexually Transmitted Disease Control, New York City Department of Health and Mental Hygiene, New York City, NY, USA
    J Acquir Immune Defic Syndr 58:408-16. 2011
    ..with men (MSM) in New York City, compare their demographics, risk behaviors, and new HIV and primary and secondary (P&S) syphilis rates with those of men who have sex with women (MSW), and examine trends in infection rates among MSM.
  35. ncbi The influence of social and sexual networks in the spread of HIV and syphilis among men who have sex with men in Shanghai, China
    Kyung Hee Choi
    Center for AIDS Prevention Studies, University of California, San Francisco, San Francisco, CA 94105, USA
    J Acquir Immune Defic Syndr 45:77-84. 2007
    To analyze characteristics of social and sexual networks and their role as risk factors for HIV and syphilis among men who have sex with men (MSM) in Shanghai, China.
  36. ncbi Evaluation of rapid diagnostic tests: syphilis
    Alan Herring
    Veterinary School, University of Bristol, Langford House, Langford, North Somerset, BS40 5DN, UK
    Nat Rev Microbiol 4:S33-40. 2006
  37. pmc Systematic differences in risk behaviors and syphilis prevalence across types of female sex workers: a preliminary study in Liuzhou, China
    Jing Li
    National Center for STD Control, Chinese Academy of Medical Science and Peking Union Medical College Institute of Dermatology, Nanjing, China
    Sex Transm Dis 39:195-200. 2012
    ..Categorization of FSWs can help prioritize HIV/STI intervention efforts. We examined 2 possible categorizations of FSWs and the relationship with syphilis infection risk in Liuzhou City, China.
  38. ncbi High prevalence of macrolide resistant Treponema pallidum strains in a London centre
    Craig Tipple
    Jefferiss Trust Laboratories, Wright Fleming Institute, Imperial College London, Norfolk Place, London W2 1PG, UK
    Sex Transm Infect 87:486-8. 2011
    ..The authors aimed to establish the strain types of T pallidum isolated from patients in a London sexual health centre and to determine the frequency of macrolide resistance...
  39. ncbi Cerebrospinal fluid abnormalities in patients with syphilis: association with clinical and laboratory features
    Christina M Marra
    Department of Neurology, University of Washington School of Medicine, Seattle, Washington, USA
    J Infect Dis 189:369-76. 2004
    ..To define clinical and laboratory features that identify patients with neurosyphilis...
  40. pmc Syphilis test availability and uptake at medical facilities in southern China
    Li Gang Yang
    Guangdong Provincial Center for STI Control and Prevention, Division of STD Control, No 10 Xian Lie Dong Heng Rd, Guangzhou 510500, China
    Bull World Health Organ 89:798-805. 2011
    To examine syphilis testing capacity, screening coverage rates and types of syphilis tests used in medical facilities in southern China.
  41. pmc Condom use and prevalence of syphilis and HIV among female sex workers in Andhra Pradesh, India - following a large-scale HIV prevention intervention
    Hari Kumar Rachakulla
    Division of Community Studies, National Institute of Nutrition, Hyderabad, India
    BMC Public Health 11:S1. 2011
    ..This manuscript describes an assessment of this intervention using the published Avahan evaluation framework and assesses the coverage, outcomes and changes in STI and HIV prevalence among FSWs...
  42. ncbi Sequencing-based molecular typing of treponema pallidum strains in the Czech Republic: all identified genotypes are related to the sequence of the SS14 strain
    Magdalena Flasarová
    Department of Biology, Faculty of Medicine, Masaryk University, Kamenice 5, Building A6, 625 00 Brno, Czech Republic
    Acta Derm Venereol 92:669-74. 2012
    A set of 415 clinical samples isolated from 294 patients suspected of having syphilis collected in the Czech Republic between 2004 and 2010 was tested for the presence of treponemal DNA...
  43. ncbi Reexamining syphilis: an update on epidemiology, clinical manifestations, and management
    Molly E Kent
    Department of Pharmacy, University of Maryland Medical Center, Baltimore, MD, USA
    Ann Pharmacother 42:226-36. 2008
    To review the epidemiology, clinical features, diagnosis, and treatment of syphilis.
  44. ncbi Syphilis and methamphetamine use among female sex workers in Shandong Province, China
    Meizhen Liao
    Department of Epidemiology and Biostatistics, School of Public Health, Shandong University, Jinan, Shandong Province 250012, People s Republic of China
    Sex Transm Dis 38:57-62. 2011
    A study of female sex workers in China, found alarmingly high prevalence of methamphetamine use. Methamphetamine users were more likely to be single, younger, inconsistent condom users, and have syphilis.
  45. pmc Text messaging for enhancement of testing and treatment for tuberculosis, human immunodeficiency virus, and syphilis: a survey of attitudes toward cellular phones and healthcare
    Anna K Person
    Division of Infectious Diseases and International Health, Duke University Medical Center, Durham, North Carolina 27710, USA
    Telemed J E Health 17:189-95. 2011
    ....
  46. ncbi Maternal Herpes simplex virus type 2 infection, syphilis and risk of intra-partum transmission of HIV-1: results of a case control study
    Frances M Cowan
    Centre for Sexual Health and HIV Research, Royal Free and University College Medical School, University College London, UK
    AIDS 22:193-201. 2008
    Genital ulcer disease including that caused by Herpes simplex virus type 2 (HSV-2) and syphilis facilitates sexual transmission of HIV-1...
  47. ncbi On-site rapid antenatal syphilis screening with an immunochromatographic strip improves case detection and treatment in rural South African clinics
    Rachel N Bronzan
    Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Sex Transm Dis 34:S55-60. 2007
    Congenital syphilis is a significant cause of adverse pregnancy outcomes. In South Africa, rural clinics perform antenatal screening offsite, but unreliable transport and poor client follow up impede effective treatment...
  48. ncbi Accelerating worldwide syphilis screening through rapid testing: a systematic review
    Joseph D Tucker
    National Center for STD Control, Chinese Academy of Medical Sciences Institute of Dermatology, Nanjing, China
    Lancet Infect Dis 10:381-6. 2010
    b>Syphilis is a persistent public health issue in many low-income countries that have limited capacity for testing, which traditionally relies on a sensitive non-treponemal test and then a specific treponemal test...
  49. ncbi The incidence of syphilis, HIV and HCV and associated factors in a cohort of men who have sex with men in Nanjing, China
    Chun Hao
    Centre for Health Behaviors Research, School of Public Health and Primary Care, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, PR China
    Sex Transm Infect 87:199-201. 2011
    This study investigated the incidence of syphilis, HIV and hepatitis C virus (HCV), as well as factors associated with syphilis seroconversion among men who have sex with men (MSM) in Nanjing, China.
  50. pmc Male circumcision and risk of syphilis, chancroid, and genital herpes: a systematic review and meta-analysis
    H A Weiss
    MRC Tropical Epidemiology Group, Infectious Disease Epidemiology Unit, Keppel Street, London WC1E 7HT, UK
    Sex Transm Infect 82:101-9; discussion 110. 2006
    ..Our objective was to conduct a systematic review and meta-analyses of the associations between male circumcision and infection with herpes simplex virus type 2 (HSV-2), Treponema pallidum, or Haemophilus ducreyi...
  51. pmc Prevalence of HIV infection and predictors for syphilis infection among female sex workers in southern China
    Fan Lu
    National Center for AIDS STD Control and Prevention, China Center for Disease Control and Prevention, Beijing, PR China
    Southeast Asian J Trop Med Public Health 40:263-72. 2009
    The purpose of this study was to assess the prevalence and risk factors for syphilis infection among female sex workers (FSWs) in Liuzhou City, Guangxi Zhuang Autonomous Region, southern China...
  52. pmc Complete genome sequence of Treponema pallidum ssp. pallidum strain SS14 determined with oligonucleotide arrays
    Petra Matejková
    Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Alkek N1619, Houston, TX 77030, USA
    BMC Microbiol 8:76. 2008
    b>Syphilis spirochete Treponema pallidum ssp. pallidum remains the enigmatic pathogen, since no virulence factors have been identified and the pathogenesis of the disease is poorly understood...
  53. ncbi Frequent testing of highly sexually active gay men is required to control syphilis
    Richard T Gray
    National Centre in HIV Epidemiology and Clinical Research, The University of New South Wales, Sydney, Australia
    Sex Transm Dis 37:298-305. 2010
    The incidence of syphilis infections has been substantially increasing in gay men in the developed world.
  54. pmc Genome analysis of Treponema pallidum subsp. pallidum and subsp. pertenue strains: most of the genetic differences are localized in six regions
    Lenka Mikalová
    Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czech Republic
    PLoS ONE 5:e15713. 2010
    ..p. pallidum and T. p. pertenue strains. These regions of sequence divergence could be used for the molecular detection and discrimination of syphilis and yaws strains.
  55. pmc Novel point-of-care test for simultaneous detection of nontreponemal and treponemal antibodies in patients with syphilis
    Arnold R Castro
    Laboratory Reference and Research Branch, Division of STD Prevention, Centers for Disease Control and Prevention, 1600 Clifton Road, MS A 12, Atlanta, GA 30333, USA
    J Clin Microbiol 48:4615-9. 2010
    ..test for the simultaneous detection of both nontreponemal and treponemal antibodies in the sera of patients with syphilis that acts as both a screening and a confirmatory test...
  56. ncbi Frequent screening for syphilis as part of HIV monitoring increases the detection of early asymptomatic syphilis among HIV-positive homosexual men
    Melanie Bissessor
    Melbourne Sexual Health Centre, Victoria, Australia
    J Acquir Immune Defic Syndr 55:211-6. 2010
    b>Syphilis continues to be a significant public health problem among HIV-positive men who have sex with men (MSM) internationally...
  57. ncbi HIV, syphilis, hepatitis C and risk behaviours among commercial sex male clients in Sichuan province, China
    Cui Yang
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 2213 McElderry Street, 2nd Floor, Baltimore 21205, USA
    Sex Transm Infect 86:559-64. 2010
    ..This study reports the prevalence of HIV, syphilis and hepatitis C virus (HCV), a history of STI and HIV-related risk behaviours in a sample of 600 CSMC in three ..
  58. pmc Transcriptome of Treponema pallidum: gene expression profile during experimental rabbit infection
    David Smajs
    Human Genome Sequencing Center, University of Texas Houston Medical School, Houston, Texas, USA
    J Bacteriol 187:1866-74. 2005
    RNA transcript levels in the syphilis spirochete Treponema pallidum subsp. pallidum (Nichols) isolated from experimentally infected rabbits were determined by the use of DNA microarray technology. This characterization of the T...
  59. ncbi High prevalence of syphilis and other sexually transmitted diseases among sex workers in China: potential for fast spread of HIV
    A van den Hoek
    Municipal Health Service, Amsterdam, The Netherlands
    AIDS 15:753-9. 2001
    ..Staff of a maternal and neonatal hospital in Guangzhou felt the need for an STD care and prevention programme for sex workers outside detention, and started a programme within their hospital, which was unique in the Chinese context...
  60. ncbi China's syphilis epidemic: a systematic review of seroprevalence studies
    Charles C Lin
    University of California, San Francisco School of Medicine, San Francisco, California, USA
    Sex Transm Dis 33:726-36. 2006
    The objective of this study was to investigate syphilis prevalence among low- and high-risk groups in China.
  61. ncbi High prevalence of risk behaviour concurrent with links to other high-risk populations: a potentially explosive HIV epidemic among men who have sex with men in Guangzhou, China
    Q He
    School of Public Health, Sun Yat Sen University, Center for Disease Prevention and Control of Guangdong Province, 74 Zhongshan Road, Guanghou, PR China, 510080 corrected
    Sex Transm Infect 85:383-90. 2009
    ..The aim of this study is to detect the epidemic and to determine the characteristics of MSM in Guangzhou susceptible to HIV...
  62. ncbi The increasing prevalence of serologic markers for syphilis among Chinese blood donors in 2008 through 2010 during a syphilis epidemic
    Jing Liu
    Westat, Inc, Rockville, Maryland, USA
    Transfusion 52:1741-9. 2012
    In China, the growing syphilis epidemic parallels the spread of human immunodeficiency virus (HIV) in the general population...
  63. ncbi Dilemmas in the management of syphilis: a survey of infectious diseases experts
    Deborah Dowell
    Epidemic Intelligence Service, Office of Workforce and Career Development, Emory University, Atlanta, Georgia, USA
    Clin Infect Dis 49:1526-9. 2009
    We surveyed infectious diseases consultants to determine how they manage syphilis when there are insufficient data to guide management or when guidelines cannot be followed because of a lack of available definitive diagnostic tests...
  64. ncbi Could implementation of Australia's national gay men's syphilis action plan have an indirect effect on the HIV epidemic?
    Alexander Hoare
    National Centre in HIV Epidemiology and Clinical Research, The University of New South Wales, Sydney, Australia
    Sex Health 9:144-51. 2012
    The number of incident infections of syphilis and HIV have increased over the past decade across Australia, particularly among gay men...
  65. pmc Seroprevalence of human immunodeficiency virus, hepatitis B and C viruses and syphilis among blood donors in Koudougou (Burkina Faso) in 2009
    Marius Bolni Nagalo
    National Blood Transfusion Centre CNTS, Ouagadougou, Burkina Faso
    Blood Transfus 9:419-24. 2011
    ..diseases such as human immunodeficiency virus (HIV), hepatitis B virus (HBV), hepatitis C virus (HCV) and syphilis in sub-Saharan Africa affects the safety of blood for recipients...
  66. pmc Antenatal screening for HIV, hepatitis B and syphilis in the Netherlands is effective
    Eline L M Op de Coul
    Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    BMC Infect Dis 11:185. 2011
    ..Here, we describe the evaluation of the effectiveness of antenatal screening in the Netherlands for 2006-2008 for HIV, hepatitis B virus (HBV) and syphilis in preventing mother-to-child transmission, by using various data sources.
  67. ncbi A phase III equivalence trial of azithromycin versus benzathine penicillin for treatment of early syphilis
    Edward W Hook
    University of Alabama at Birmingham and Jefferson County Department of Health, Birmingham, AL, USA
    J Infect Dis 201:1729-35. 2010
    b>Syphilis remains an important source of morbidity worldwide. Long-acting penicillin is the only therapy currently recommended for syphilis in much of the world...
  68. pmc Draft genome sequence of a dominant, multidrug-resistant Neisseria gonorrhoeae strain, TCDC-NG08107, from a sexual group at high risk of acquiring human immunodeficiency virus infection and syphilis
    Chun Chen Chen
    Research and Diagnostic Center, Centers for Disease Control, No 161, Kun Yang Street, Taipei, Taiwan
    J Bacteriol 193:1788-9. 2011
    ..Herein, we report the availability of the draft genome sequence of a multidrug-resistant N. gonorrhoeae isolate, TCDC-NG08107, which spread in groups of men who have sex with men (MSM) in Taiwan...
  69. ncbi Risk of sexually transmitted infections and violence among indoor-working female sex workers in London: the effect of migration from Eastern Europe
    Lucy Platt
    Department of Social and Environmental Health Research, London School of Hygiene and Tropical Medicine, 15 17 Tavistock Place, London WC1H 9SH, UK
    Sex Transm Infect 87:377-84. 2011
    ....
  70. pmc Herpes simplex virus type 2 and syphilis infections with HIV: an evolving synergy in transmission and prevention
    Aaron Ar Tobian
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, USA
    Curr Opin HIV AIDS 4:294-9. 2009
    Herpes simplex virus type 2 (HSV-2) and syphilis are associated with HIV infection...
  71. pmc Enhanced molecular typing of treponema pallidum: geographical distribution of strain types and association with neurosyphilis
    Christina M Marra
    Departments of Neurology, University of Washington School of Medicine, Seattle, Washington 98104 2499, USA
    J Infect Dis 202:1380-8. 2010
    ..Strain typing is a tool for determining the diversity and epidemiology of infections...
  72. ncbi Low seroprevalence of syphilis in Burkina Faso
    Fati Kirakoya-Samadoulougou
    Faculté de Santé Publique, Pôle Epidémiologie et Biostatistique, Institut de Recherche Expérimentale et Clinique, Universite Catholique de Louvain, Bruxelles, Belgium
    Sex Transm Infect 87:35-7. 2011
    Little information is available on the epidemiology of syphilis in West Africa, where this infection is routinely screened in antenatal clinics to prevent congenital infection...
  73. ncbi Syphilis among female sex workers in southwestern China: potential for HIV transmission
    Yuhua Ruan
    State Key Laboratory for Infectious Disease Prevention and Control, National Center for AIDS STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China
    Sex Transm Dis 33:719-23. 2006
    The objective of this study was to investigate the prevalence and risk factors of syphilis infection among female sex workers in a southwestern Chinese city along a drug trafficking route.
  74. pmc Comparison of the diagnostic accuracy of a rapid immunochromatographic test and the rapid plasma reagin test for antenatal syphilis screening in Mozambique
    Pablo J Montoya
    Health Alliance International, Maputo, Mozambique
    Bull World Health Organ 84:97-104. 2006
    Programmes to control syphilis in developing countries are hampered by a lack of laboratory services, delayed diagnosis, and doubts about current screening methods...
  75. pmc TprC/D (Tp0117/131), a trimeric, pore-forming rare outer membrane protein of Treponema pallidum, has a bipartite domain structure
    Arvind Anand
    Departments of Medicine, University of Connecticut Health Center, Farmington, Connecticut, USA
    J Bacteriol 194:2321-33. 2012
    Identification of Treponema pallidum rare outer membrane proteins (OMPs) has been a longstanding objective of syphilis researchers...
  76. pmc A twin response to twin epidemics: integrated HIV/syphilis testing at STI clinics in South China
    Joseph D Tucker
    STD Control Department, Guangdong Provincial Center for Skin Diseases and STD Control, Guangzhou, China
    J Acquir Immune Defic Syndr 57:e106-11. 2011
    HIV testing is still stigmatized among many high-risk groups in China, whereas routine syphilis testing has been widely accepted at sexually transmitted infection (STI) clinics...
  77. pmc Seroprevalence of HIV, HBV, HCV and syphilis infections among blood donors at Gondar University Teaching Hospital, Northwest Ethiopia: declining trends over a period of five years
    Belay Tessema
    Department of Medical Laboratory Technology, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia
    BMC Infect Dis 10:111. 2010
    ..agents such as human immunodeficiency virus (HIV), hepatitis B virus (HBV), hepatitis C virus (HCV) and syphilis are among the greatest threats to blood safety for the recipient...
  78. pmc Ocular syphilis among HIV-infected patients: a systematic analysis of the literature
    Joseph D Tucker
    Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, 55 Fruit Street, GRJ 504, Boston 02114, USA
    Sex Transm Infect 87:4-8. 2011
    Ocular syphilis among HIV-infected patients continues to be a problem in the highly active antiretroviral therapy (HAART) era...
  79. ncbi Incarcerated sex workers and HIV prevention in China: social suffering and social justice countermeasures
    Joseph Tucker
    Massachusetts General Hospital, Division of Infectious Diseases, GRJ 504, 55 Fruit Street, Boston, MA 02114, USA
    Soc Sci Med 70:121-9. 2010
    ..Chinese sex worker detention camp practices may not only systematically increase HIV/syphilis risk among ISW, but also work to narrow women's social spheres of influence, a particularly cruel tragedy in a ..
  80. pmc Preliminary evaluation of an immunochromatographic strip test for specific Treponema pallidum antibodies
    Pinar Zarakolu
    Section of Infectious Diseases, Department of Medicine, School of Medicine, Hacettepe University, Ankara, Turkey
    J Clin Microbiol 40:3064-5. 2002
    ..For sera from 43 syphilis patients, the ICSs were reactive, while for sera from 114 patients without syphilis, including 22 with ..
  81. ncbi Retinal vasculitis due to secondary syphilis
    Masahiko Yokoi
    Department of Ophthalmology, Teine Keijin kai Hospital, Sapporo, Japan
    Jpn J Ophthalmol 48:65-7. 2004
    BACKGROUND: Retinal vasculitis is one of the manifestations of ocular syphilis. CASE: A 29-year-old man was referred to our hospital with the complaint of sudden visual loss in the left eye lasting more than three weeks...
  82. pmc A cross-sectional study of HIV and syphilis infections among male students who have sex with men (MSM) in northeast China: implications for implementing HIV screening and intervention programs
    Jun Jie Xu
    Key Laboratory of AIDS Immunology of Ministry of Health, Department of Laboratory Medicine, NO, 1 Hospital of China Medical University, Shenyang 110001, China
    BMC Public Health 11:287. 2011
    ..Most of these cases are attributed to male-to-male sexual contact. Few studies have explored HIV prevalence and behavioural characteristics of Chinese male students who have sex with men (MSM)...
  83. ncbi [A respondent-driven sampling survey on HIV and risk factors among men who have sex with men in Chongqing]
    Lin Ouyang
    Chongqing Center for Disease Control and Prevention, Chongqing 400042, China
    Zhonghua Liu Xing Bing Xue Za Zhi 30:1001-4. 2009
    ..To examine HIV prevalence and related risk factors among men who have sex with men (MSM) in Chongqing, and to explore the feasibility of using respondent-driven sampling (RDS) in the survey...
  84. pmc CXCL13 as a cerebrospinal fluid marker for neurosyphilis in HIV-infected patients with syphilis
    Christina M Marra
    Departments of Neurology, University of Washington School of Medicine, Seattle, 98104, USA
    Sex Transm Dis 37:283-7. 2010
    ..The proportion of CSF lymphocytes that are B cells is elevated in neurosyphilis, suggesting that the CSF concentration of the B cell chemoattractant, chemokine (C-X-C motif) ligand 13 (CXCL13) concentration may also be elevated...
  85. pmc Increasing detection of asymptomatic syphilis in HIV patients
    C E Cohen
    Department of GU HIV Medicine, St Stephen s Centre, 2nd Floor, Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, UK
    Sex Transm Infect 81:217-9. 2005
    The burden of new syphilis diagnoses in London has mainly been in men who have sex with men (MSM), many of whom are co-infected with HIV...
  86. ncbi Chancroid, primary syphilis, genital herpes, and lymphogranuloma venereum in Antananarivo, Madagascar
    F M Behets
    Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7030, USA
    J Infect Dis 180:1382-5. 1999
    ..Sera were tested for syphilis and for IgG and IgM antibodies to Chlamydia trachomatis by microimmunofluorescence testing (MIF)...
  87. pmc Antibody responses elicited against the Treponema pallidum repeat proteins differ during infection with different isolates of Treponema pallidum subsp. pallidum
    Brandon T Leader
    Department of Pathobiology, University of Washington, Seattle, WA 98195 7185, USA
    Infect Immun 71:6054-7. 2003
    Variation in the expression of the different Tpr proteins in the syphilis spirochete, Treponema pallidum subsp. pallidum, may have important implications in its ability to evade host immune detection and cause persistent infection...
  88. ncbi [HIV prevalence and its associated factors among men who have sex with men in Chongqing]
    Lian gui Feng
    Chongqing Center for Disease Control and Prevention, Chongqing 400042, China
    Zhonghua Yu Fang Yi Xue Za Zhi 42:870-4. 2008
    ..To examine HIV prevalence and its associated factors among men who have sex with men (MSM) and provide the evidence for the intervention program among MSM...
  89. pmc Footprint of positive selection in Treponema pallidum subsp. pallidum genome sequences suggests adaptive microevolution of the syphilis pathogen
    Lorenzo Giacani
    Department of Medicine, University of Washington, Seattle, WA, USA
    PLoS Negl Trop Dis 6:e1698. 2012
    In the rabbit model of syphilis, infection phenotypes associated with the Nichols and Chicago strains of Treponema pallidum (T. pallidum), though similar, are not identical...
  90. ncbi Use of a computer alert increases detection of early, asymptomatic syphilis among higher-risk men who have sex with men
    Melanie Bissessor
    Melbourne Sexual Health Centre, Carlton, Victoria, Australia
    Clin Infect Dis 53:57-8. 2011
    Our study assessed the impact of a computer alert that reminded clinicians to test men who were at higher risk for syphilis on the rate of syphilis testing and diagnoses...
  91. pmc Relation between the HIV and the re-emerging syphilis epidemic among MSM in Germany: an analysis based on anonymous surveillance data
    U Marcus
    Robert Koch Institut, Berlin, Germany
    Sex Transm Infect 81:456-7. 2005
    ..In this group the number of newly diagnosed HIV infections increased about 30% compared to 2002. Since the late 1990s syphilis infections among MSM also increased in Germany, concentrated in larger cities.
  92. pmc Global challenge of antibiotic-resistant Treponema pallidum
    LOLA V STAMM
    Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7435, USA
    Antimicrob Agents Chemother 54:583-9. 2010
    b>Syphilis is a multistage infectious disease that is usually transmitted through contact with active lesions of a sexual partner or from an infected pregnant woman to her fetus...
  93. pmc HIV infection and risk characteristics among female sex workers in Hanoi, Vietnam
    Trung Nam Tran
    Department of Epidemiology, University of California, Los Angeles, School of Public Health, Los Angeles, CA 90095 1772, USA
    J Acquir Immune Defic Syndr 39:581-6. 2005
    ..Four hundred FSWs were interviewed face to face using a structured questionnaire and tested for HIV, syphilis, Chlamydia infection, and gonorrhea...
  94. pmc Lives Saved Tool supplement detection and treatment of syphilis in pregnancy to reduce syphilis related stillbirths and neonatal mortality
    Hannah Blencowe
    London School of Hygiene and Tropical Medicine, London, UK
    BMC Public Health 11:S9. 2011
    Globally syphilis is an important yet preventable cause of stillbirth, neonatal mortality and morbidity.
  95. ncbi Treatment of syphilis in pregnancy and prevention of congenital syphilis
    George D Wendel
    Department of Obstetrics and Gynecology, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9032, USA
    Clin Infect Dis 35:S200-9. 2002
    Studies about the management of syphilis during pregnancy were reviewed. They lacked uniformity in diagnostic criteria and study design...
  96. ncbi Opsonic potential, protective capacity, and sequence conservation of the Treponema pallidum subspecies pallidum Tp92
    C E Cameron
    Department of Medicine, University of Washington, Seattle, WA 98195, USA
    J Infect Dis 181:1401-13. 2000
    ..pallidum challenge. These results demonstrate that Tp92 is an invariant, immunoprotective antigen that may be present on the surface of T. pallidum and may represent a potential vaccine candidate for syphilis.
  97. ncbi Tracing a syphilis outbreak through cyberspace
    J D Klausner
    STD Services, 1360 Mission St, Suite 401, San Francisco, CA 94103, USA
    JAMA 284:447-9. 2000
    A recent outbreak of syphilis among users of an Internet chat room challenged traditional methods of partner notification and community education because locating information on sexual partners was limited to screen names and privacy ..
  98. pmc Correlates of incident infections for HIV, syphilis, and hepatitis B virus in a cohort of men who have sex with men in Beijing
    Dongliang Li
    Chaoyang Center for Disease Control and Prevention, Xuanwu District, Beijing, P R China
    AIDS Patient Care STDS 24:595-602. 2010
    Recent data suggest that the prevalence of HIV/syphilis infections among men who have sex with men (MSM) in China increased rapidly...
  99. ncbi HIV, syphilis and heterosexual bridging among Peruvian men who have sex with men
    Stephen Tabet
    Department of Medicine, University of Washington, Seattle, Washington, USA
    AIDS 16:1271-7. 2002
    To determine prevalence of and risk factors associated with HIV and syphilis seropositivity and estimate incidence of HIV infection among Peruvian men who have sex with men (MSM) and characterize behaviors of men who report sex with both ..
  100. pmc Molecular differentiation of Treponema pallidum subspecies
    Arturo Centurion-Lara
    Department of Medicine, University of Washington, Seattle, 98195, USA
    J Clin Microbiol 44:3377-80. 2006
    ..pallidum subspecies, as well as a simian treponeme...
  101. ncbi Prevalence of sexually transmitted infections among men who have sex with men in Zagreb, Croatia
    Ivana Bozicevic
    Andrija Stampar School of Public Health, Rockefellerova 4, 10 000 Zagreb, Croatia
    AIDS Behav 13:303-9. 2009
    ..b>Syphilis seroprevalence was 10.6%. Prevalence of Chlamydia and gonorrhoea was 9.0%, and 13.2%, respectively...

Research Grants76

  1. Vaccine Development for Falciparum Malaria in Pregnant Women and Their Offspring
    Ian C Michelow; Fiscal Year: 2013
    ..Diseases and Tropical Medicine, his research on diagnostic tests for children with pneumonia or congenital syphilis, and his laboratory work on production of novel immunotherapeutics for glycosylated virus infections, have laid a ..
  2. A unique approach to identify markers for congenital syphilis and neurosyphilis
    Nikhat Parveen; Fiscal Year: 2010
    ..Challenge Topic- 15-OD(ORDR)-101*: Pilot projects for prevention, early detection and treatment of rare diseases, Syphilis is a chronic, multisystemic disease caused by the spirochete, Treponema pallidum subspecies pallidum (T...
  3. CSHL 2010 Conference on Molecular Genetics and Bacteria & Phages
    David J Stewart; Fiscal Year: 2010
    ..conditions, bacteria are responsible for many important infectious diseases such as tuberculosis, cholera or syphilis. Much as plants and animals have viruses, so bacteria can be infected by bacteriophages that alter their ..
  4. 2012 CSHL Bacteria &Phages Conference
    David J Stewart; Fiscal Year: 2012
    ..conditions, bacteria are responsible for many important infectious diseases such as tuberculosis, cholera or syphilis. Much as plants and animals have viruses, so bacteria can be infected by bacteriophages that alter their ..
  5. Functional Consequence of Macrolide Resistance Mutations in T. pallidum
    Sheila A Lukehart; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): For many years, a single-dose oral treatment for syphilis has been sought...
  6. Multilevel Targeted Therapeutics Using Surface Functionalized Nanoparticles encap
    JILL STEINBACH; Fiscal Year: 2012
    ..increases the likelihood of human immunodeficiency (HIV) coinfection 6-fold and increases HIV, Chlamydia, and syphilis prevalence in third-world countries...
  7. Development of an HIV Risk Reduction Intervention Protocol for Adolescent Africn-
    GWENDOLYN D CHILDS; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Alabama STI surveillance reports reveal rates of chlamydia, syphilis, and gonorrhea among African American (AA) girl increase more than 1000% between age groups 10 to 14 and 15 to 19, suggesting ..
  8. HAART optimism, drug use and risky sexual behavior among MSM in British Columbia.
    Robert Stephen Hogg; Fiscal Year: 2013
    ..form, complete a questionnaire using Computer Assisted Self-Interview technology, and undergo a rapid HIV test, syphilis test, hepatitis C serology, urine and anal swab screens for N...
  9. Crossing Borders: HIV and Substance use at the Gateway to North America
    Kimberly C Brouwer; Fiscal Year: 2013
    ..All will be tested for HIV, syphilis, herpes simplex virus-2, and HCV, and treated as needed...
  10. 2009 Spirochetes, Biology of
    David A Haake; Fiscal Year: 2010
    ..Many spirochetes are pathogens, and they cause a variety of diseases, including syphilis, Lyme disease, relapsing fever, leptospirosis, periodontal disease, digital dermatitis of cattle, and swine and ..
  11. Antigenic Variation of TprK in Treponema pallidum
    Sheila A Lukehart; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The incidence of infectious syphilis has doubled in the United States since 2000, and has increased dramatically in Western Europe and in China during that time...
  12. Sexual Health among Low-Income Female CSWs in China
    JENNIFER ZHIHUAN HUANG BOUEY; Fiscal Year: 2011
    ..are to: (1) describe and compare the prevalence of unprotected sexual practices and STIs (Chlamydia, gonorrhea, syphilis, HSV-2, and HBV) between migrant and non-migrant street walkers;(2) describe and compare the characteristics of ..
  13. Improving blood safety and HIV testing in Brazil: a randomized controlled trial
    THELMA THEREZINHA GONCALEZ; Fiscal Year: 2013
    ..Secondary outcomes include differences in prevalence of transfusion-transmitted infections (HIV, HCV, HBV, syphilis, HTLV I/II, Chagas disease), donor motivations (e.g., test-seeking vs...
  14. Institutional Collaboration between LSTM and CDC and Prevention on Malaria(U01)
    FEIKO OLAF TER KUILE; Fiscal Year: 2013
    ..of integrated approaches to disease control which combine screening for HIV with scheduled screening for malaria, syphilis and anemia, and use of intermittent screening and treatment of malaria in pregnancy...
  15. Multiple Antigen Point-of-Care Device for Improved Syphilis Diagnosis
    Michael J Lochhead; Fiscal Year: 2010
    ..Corporation (mBio/PPC) is developing a low-cost, point-of-care (POC), combination Treponemal/Nontreponemal Syphilis diagnostic device...
  16. Mechanisms of Immune Evasion and Recognition in Human Syphilis
    ADRIANA RAQUEL CRUZ; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Syphilis, a multi-stage sexually transmitted disease caused by the spirochete Treponema pallidum (Tp), continues to be a major worldwide public health problem...
  17. Natural competence and genetic manipulation of Treponema pallidum
    Lorenzo Giacani; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): The incidence of primary and secondary syphilis has nearly doubled in the United States since 2000, and has increased dramatically in Western Europe and China during that time...
  18. NOVEL BIOMARKERS FOR MECHANISTIC DIAGNOSIS OF THE ANTIPHOSPHOLIPID SYNDROME
    JACOB RAND; Fiscal Year: 2010
    ..that were developed over 25 years ago - the aPL immunoassays which were derived from the "biologic false positive syphilis" test and a coagulation inhibitor known as the lupus anticoagulant (LA)...
  19. Lumbar Puncture and Syphilis Outcome
    Christina M Marra; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The role of lumbar puncture (LP) in syphilis is controversial, particularly in HIV-infected patient...
  20. Structural Behavioral HIV Prevention for Male Sex Workers in Peru
    Angela M Bayer; Fiscal Year: 2013
    ..8-22.3% and recent syphilis infection of 10.5% among men who have sex with only men. Dr. Coates, Dr...
  21. UNC-South China STD Research Training Center
    JOSEPH DAVID TUCKER; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Syphilis has become the most commonly reported communicable disease in most major cities of South China, drawing attention to the resurgence of STDs all over the country...
  22. Evolving HIV/STI risk environments of FSWs on the Mexico/U.S. Border
    Kimberly C Brouwer; Fiscal Year: 2013
    ..All will be tested for HIV, syphilis, gonorrhea, and Chlamydia and treated as needed...
  23. Treponema pallidum:Pathogenesis-associated molecules
    Sheila A Lukehart; Fiscal Year: 2013
    ..The resulting diseases-venereal syphilis, yaws, bejel, and pinta-are all chronic, potentially debilitating and disfiguring diseases...
  24. Social network and sexual risk for HIV/STIs among older female sex workers
    Hongjie Liu; Fiscal Year: 2013
    ..network factors for sexual risk among older Chinese female sex workers;(2) determine the prevalence of HIV and syphilis;and (3) quantitatively examine the collective roles of social network components and environmental factors on ..
  25. Safer sex intervention for male clients of female sex workers in Tijuana, Mexico
    Thomas L Patterson; Fiscal Year: 2013
    ..will be recruited in Tijuana where they will undergo a baseline CAPI-administered interview, STI testing (HIV, syphilis, gonorrhea, Chlamydia), and intervention counseling with follow-up interviews at 4, 8, and 12 months post-..
  26. Denver Prevention Training Center
    Mark W Thrun; Fiscal Year: 2010
    ..which include increasing CT &GC screening, treatment and partner treatment; decreasing primary and secondary syphilis;decreasing congenital syphilis;decreasing the numbers of persons at high risk for acquiring or transmitting HIV ..
  27. Couples-Based HIV/STI Prevention for Injecting Drug Users in Kazakhstan
    Nabila El-Bassel; Fiscal Year: 2012
    ..outcomes are the rate of new HIV cases and new HCV cases, as well as the incidence of Chlamydia, gonorrhea, and syphilis over the 12-month post-intervention period...
  28. NATIONAL HIV BEHAVIORAL SURVEILLANCE SYSTEM
    Alan Neaigus; Fiscal Year: 2013
    ..Additionally, DOHMH will conduct testing for hepatitis B, hepatitis C, herpes simplex virus-2, and syphilis during all study cycles...
  29. Texas National HIV Behavioral Surveillance
    Jonathan Poe; Fiscal Year: 2013
    ..Additionally, voluntary and anonymous hepatitis B (HBV), hepatitis C (HCV), and syphilis testing will be conducted on consenting participants to estimate HBV, HCV, and syphilis seroprevalence...
  30. Preventing HIV Infection Among MSM in Southern India
    David D Celentano; Fiscal Year: 2013
    ..acts in prior six months;(2) number of non-primary partners in prior 6 months;(3) prevalence of HIV, HSV-2 and syphilis;(4) prevalence of substance abuse;and (5) prevalence of depressive symptoms...
  31. Disparities in sexually transmitted infections among young women: Role of individ
    SARAH ELIZABETH WIEHE; Fiscal Year: 2010
    ..mechanisms may contribute to the spread of various STI differently, we will evaluate Chlamydia, gonorrhea, syphilis, and HIV independently and in combination...
  32. Protein-protein covalent bonding and Treponema motility
    Michael R Miller; Fiscal Year: 2013
    ..Td is similar to the syphilis spirochete T. pallidum, which is a major cause of morbidity and mortality world-wide. Both Td and T...
  33. Structure and Function of Treponema pallidum Lipoproteins
    Michael V Norgard; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Syphilis, caused by the spirochetal bacterium Treponema pallidum, continues to play prominently as a sexually transmitted disease...
  34. AIDS INTERNATIONAL TRAINING AND RESEARCH PROGRAM
    WARREN DOUGLAS JOHNSON; Fiscal Year: 2012
    ..HIV Clinical Trials Unit (CTU) for HIV vaccine and antiretroviral clinical trials;WHO/TDR tuberculosis and syphilis research;United Nations Global Fund for AIDS, Tuberculosis and Malaria;President's Emergency Plan for AIDS ..
  35. Persistence of CNS T. pallidum in HIV Infection
    Christina M Marra; Fiscal Year: 2012
    Throughout the world, 12 million people acquire syphilis every year...
  36. Pilot Study of Skills-Building as HIV Prevention for Male Sex Workers in Peru
    Thomas J Coates; Fiscal Year: 2013
    ..Results revealed high prevalences of HIV(23%) and syphilis (22%) infections among low-income fletes and an urgent need for HIV prevention interventions that specifically ..
  37. 2012 Biology of Spirochetes Gordon Research Conference
    David A Haake; Fiscal Year: 2012
    ..Many spirochetes are pathogens and cause a variety of human and animal diseases, including syphilis, leptospirosis, Lyme borreliosis, relapsing fever, periodontal disease and dysentery...
  38. Understanding Unique Aspects of Motility and Chemotaxis in Borrelia burgdorferi
    Chunhao Li; Fiscal Year: 2011
    ..These organisms cause several important human diseases, such as syphilis, Lyme disease and leptospirosis...
  39. Implementation/Evaluation of TB, HIV, and Syphilis Screening in Ethiopian Prisons
    WONDWOSSEN AMOGNE DEGU; Fiscal Year: 2013
    ..propose implementing and studying a program of active screening for pulmonary tuberculosis (PTB), HIV, and syphilis in an Ethiopian Prison...
  40. At Risk Hispanic Gangs: Long-Term Consequences for Hiv, Hepatitis and STI
    Avelardo Valdez; Fiscal Year: 2011
    ..Determine the prevalence (tested) of HIV, HBV, HCV, and STIs, (chlamydia trachomatis, syphilis and herpes simplex virus-2) infection in young adulthood (n=310). 2...
  41. Proyecto Parejas: HIV/STI Risks among FSWs and their Non-Commercial Partners
    Steffanie A Strathdee; Fiscal Year: 2013
    ..e., syphilis, gonorrhea, Chlamydia, HSV-2) and associated correlates at the individual and partner level;Aim 3: To ..
  42. Syphilis: Translating technology to understand a neglected epidemic
    Carlos F Caceres; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Syphilis remains an uncontrolled infectious disease globally, with high prevalence and incidence in certain high risk populations, affecting more than 20% of men who have sex with men (MSM) in Peru...
  43. Partners for Strong, Healthy Families (PSHF)
    Frank H Galvan; Fiscal Year: 2013
    ..2 times more likely to contract gonorrhea, 2.1 times more likely to contract syphilis (CDC, 2010) and have a higher rate of HPV infection, when compared to Whites...
  44. Blood-borne infection screening in an Afghan antenatal population
    CATHERINE SUZANNE TODD; Fiscal Year: 2010
    ..investigating prevalence and correlates of and barriers to screening for human immunodeficiency virus (HIV), syphilis, and hepatitis B (HBV) in an Afghan antenatal population;and 7...
  45. MSM and Substances Cohort at UCLA Linking Infections Noting Effects (MASCULINE)
    Steven Shoptaw; Fiscal Year: 2013
    ..and infected MMSM on acquisition of HIV and other sexually transmitted infections (STIs: gonorrhea, Chlamydia, syphilis, Hepatitis C (HCV));and (ii) the extent to which substance use in MMSM facilitates behaviors that transmit HIV ..
  46. Improving HIV testing among wives of MSM in India
    Sunil Suhas Solomon; Fiscal Year: 2013
    ..group discussions, in-depth interviews and quantitative surveys including serologic testing for HIV, HSV and syphilis among two groups: 1) MSM couples (both husband and wife) where the husband has disclosed his MSM behavior to his ..
  47. Structure and Mechanism of the Flagellar Switch Complex
    David F Blair; Fiscal Year: 2013
    ..Flagellar motility is a factor in the virulence of many human pathogens, including those that cause ulcers, syphilis, urinary tract infections;burn wound infections, and some diarrhea...
  48. Transcytosis of IgG in Genital Infections
    Xiaoping Zhu; Fiscal Year: 2010
    ..of immune protection for the genital tract, and will provide the basic knowledge essential for the prevention of other STDs, including human immunodeficiency virus, vaginitis, syphilis, gonorrhea, papillomavirus, Candida albican, etc.
  49. Characterization of Treponema pallidum rare outer membrane proteins
    Justin D Radolf; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): More than a century after the discovery of Treponema pallidum (Tp), syphilis remains a major threat to global public health...
  50. Evaluating a Structural and Behavioral HIV Risk Reduction Program for Black Men
    Jay G Silverman; Fiscal Year: 2013
    ..impact on reduction in number of unprotected sex episodes and incident cases of STI (Chlamydia, gonorrhea, syphilis) via survey and STI testing, respectively, at baseline and 6 and 12 month follow-ups...
  51. Multicomponent Intervention to Reduce Sexual Risk and Substance Use
    Jeffrey T Parsons; Fiscal Year: 2013
    ..We will conduct biological testing (HIV, Chlamydia, gonorrhea, and syphilis) and collect self-report data to evaluate intervention efficacy...
  52. Simultaneous Assay for Multiple Pathogens in Blood (SAMP-B)
    Gao Chen; Fiscal Year: 2013
    ..beads in a single microwell, it is possible to simultaneously identify HIV type 1 and 2, Hepatitis B (HBV), Syphilis, Hepatitis C (HCV), Human T-Lymphotropic Virus (HTLV type I and II), West Nile Virus (WNV), and many other blood-..
  53. Supplement to Behavioral Science Aspects
    Dennis G Fisher; Fiscal Year: 2013
    ..Tests for other conditions such as hepatitis C (HCV) and syphilis are in use in other countries...
  54. Circumcision: HIV/STIs and behaviors in a RCT and post-RCT surveillance;Rakai
    Ronald H Gray; Fiscal Year: 2011
    ..We hypothesize that reduced risks of syphilis and HSV-2 will account for the protection against GUD, and this will contribute to HIV protection...
  55. Extracellular Matix Adhesins of Treponema pallidum
    Caroline E Cameron; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Syphilis remains a public health threat worldwide, with an estimated 12 million new infections per year and a global burden of 25 million infections...
  56. A low-cost point-of-care diagnostic test for simultaneous HIV-1 & STI
    SAMUEL SIA; Fiscal Year: 2009
    ..b>Syphilis and genital herpes are STI's that enhance HIV transmission;if diagnosed, they can be cured with low-cost and ..
  57. Repeat STI Patients: Tailored Socio-Contextual Intervention to Reduce HIV Risk
    Lance S Weinhardt; Fiscal Year: 2013
    ..by applicant): Repeat sexually transmitted infections (STI), such as Chlamydia, gonorrhea, trichomoniasis, and syphilis indicate persistent elevated risk activity for HIV, and repeated STI infections increase the likelihood of HIV ..
  58. HIV, Risk Behaviors, and Stigma in High Risk Tanzanian Men
    Michael W Ross; Fiscal Year: 2011
    ..Linked to this will be biological data on HIV, syphilis and urethral and rectal gonorrhea and Chlamydia...
  59. Protective Role of Interleukin 10 in Neuroborreliosis
    Diego Cadavid; Fiscal Year: 2009
    ..The major spirochetal infections of humans causing CNS infection and neurological disease include syphilis, leptospirosis, Lyme disease and relapsing fever (RF)...
  60. Johns Hopkins Adolescent Medicine Trials Unit
    Allison L Agwu; Fiscal Year: 2013
    ..Further, in his capacity as Medical Director for the Baltimore City Health Department (HCHD) Syphilis Elimination Program, Dr...
  61. Developing an HIV Prevention Intervention for HIV-Positive Men in China
    Kyung Hee Choi; Fiscal Year: 2012
    ..g., syphilis) known to facilitate sexual transmission of HIV...
  62. PS08-002, DEV AND TESTING OF HIV PREV INTERVENTION TARGETING BLACK MSM/W
    MARIA ISABEL FERNANDEZ; Fiscal Year: 2011
    ..behavioral assessments using ACASI and provide urine and blood specimens to test for chlamydia, gonorrhea, and syphilis at baseline, immediate post and 3 month post intervention...
  63. MURINE MODEL OF IMMUNOSUPPRESSION INDUCED CMV RETINITIS
    Patrick Cleveland; Fiscal Year: 1991
    ..Candida, Mycobacterium, herpes simplex herpes simplex virus, varicella zoster virus, histoplasmosis, and syphilis which have been reported in the retina of AIDS CM rarely causes retinitis in healthy adults...
  64. GENE ANALYSIS OF SPIROCHETE PERIPLASMIC FLAGELLA
    NYLES CHARON; Fiscal Year: 1999
    ..These organisms cause a variety of important diseases including syphilis, Lyme disease, relapsing fever, and leptospirosis...
  65. GORDON CONFERENCE: BIOLOGY OF THE SPIROCHETES
    JANIS WEIS; Fiscal Year: 2004
    ..Many spirochetes are pathogens and cause a variety of diseases, including syphilis, Lyme disease, relapsing fever, leptospirosis, periodontal disease, digital dermatitis of cattle, and swine and ..
  66. GORDON CONFERENCE--BIOLOGY OF THE SPIROCHETES
    JANIS WEIS; Fiscal Year: 2002
    ..Many spirochetes are pathogens and cause a variety of diseases, including syphilis, Lyme disease, relapsing fever, leptospirosis, periodontal disease, digital dermatitis of cattle, and swine and ..
  67. PHYSIOLOGIC CHARACTERISTICS OF TREPONEMA PALLIDUM
    Steven Norris; Fiscal Year: 1993
    Treponema pallidum subsp. pallidum and related organisms are helically- shaped bacteria which cause venereal syphilis, endemic syphilis, yaws and pinta in humans...
  68. IMPACT OF SOCIAL NETWORKS ON SYPHILIS TRANSMISSION
    Anne Rompalo; Fiscal Year: 2004
    ..Applicant's Abstract): The investigators propose to examine the role of social context and social influence on syphilis transmission in Baltimore...
  69. GORDON CONFERENCE: BIOLOGY OF THE SPIROCHETES
    Steven Norris; Fiscal Year: 2000
    ..Pathogenic spirochetes include those that cause syphilis, Lyme disease, relapsing fever, leptospirosis, periodontal disease, digital dermatitis of cattle, and swine and ..
  70. A Novel Approach to the Development of a Syphilis Vaccine Using Rabbit Monoclonal
    James Miller; Fiscal Year: 2009
    b>Syphilis is a global public health problem that results in significant morbidity and infant mortality...
  71. Prevention Technologies for Sexual and Reproductive Health Conference
    Susan Ivey; Fiscal Year: 2009
    ..Every year, 340 million people acquire new gonorrhea, syphilis, Chlamydia, or trichomonas infections...
  72. GENITAL ULCERATION AS A RISK FACTOR FOR HIV INFECTION
    Edward Hook; Fiscal Year: 1991
    ..traumatic sexual activity such as receptive rectal intercourse) or sexually transmitted genital ulcer discases (syphilis, genital herpes, chancroid) are risk factors for HIV acquisition...
  73. Structural Factors to Lower Alcohol-Related HIV Risk
    B R Simon Rosser; Fiscal Year: 2010
    ..structure most driving heavy alcohol use and ARHR, and thus contribute to male-male transmission of HIV, syphilis and gonorrhea. If so, the growing utilization of gay e-environments should lower risk...
  74. HIV EPIDEMIOLOGY AMONG RURAL AFRICAN-AMERICANS
    Adaora Adimora; Fiscal Year: 1999
    ..among African Americans in rural regions of the Southeastern United States, where the epidemics of gonorrhea, syphilis, and other curable STDs have also escalated...
  75. Geography, networks, and risk in disease transmission
    Richard Rothenberg; Fiscal Year: 2009
    ..on the prevalence and incidence of seven sexually transmitted and blood-borne infections (HIV, HCV, HSV-2, Syphilis, Gonorrhea, Chlamydial infection, and Trichomoniasis) in the areas with high and low burden of HIV...
  76. MOLECULAR ANALYSIS OF TREPONEMAL MOTILITY GENES
    RONALD LIMBERGER; Fiscal Year: 2002
    ..Spirochetes are the causative agents of syphilis (Treponema pallidum) and Lyme disease (Borrelia burgdorferi) and are associated with periodontal disease (..