pneumococcal pneumonia

Summary

Summary: A febrile disease caused by STREPTOCOCCUS PNEUMONIAE. This condition is characterized by inflammation of one or more lobes of the lungs and symptoms include chills, fever, rapid breathing, and cough.

Top Publications

  1. ncbi Pathogenesis, treatment, and prevention of pneumococcal pneumonia
    Tom van der Poll
    Centre for Infection and Immunity Amsterdam, Centre for Experimental and Molecular Medicine, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    Lancet 374:1543-56. 2009
  2. ncbi A trial of a 9-valent pneumococcal conjugate vaccine in children with and those without HIV infection
    Keith P Klugman
    Medical Research Council, University of the Witwatersrand, National Institute for Communicable Diseases, Respiratory and Meningeal Pathogens Research Unit, Johannesburg, South Africa
    N Engl J Med 349:1341-8. 2003
  3. pmc Association of serotype with risk of death due to pneumococcal pneumonia: a meta-analysis
    Daniel M Weinberger
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, USA
    Clin Infect Dis 51:692-9. 2010
  4. ncbi Tissue-specific contributions of pneumococcal virulence factors to pathogenesis
    Carlos J Orihuela
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    J Infect Dis 190:1661-9. 2004
  5. ncbi IL-10 is an important mediator of the enhanced susceptibility to pneumococcal pneumonia after influenza infection
    Koenraad F Van Der Sluijs
    Laboratory of Experimental Internal Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    J Immunol 172:7603-9. 2004
  6. pmc Insights into the interaction between influenza virus and pneumococcus
    Jonathan A McCullers
    Department of Infectious Diseases, St Jude Children s Research Hospital, 332 N Lauderdale St, Memphis, TN 38105 2794, USA
    Clin Microbiol Rev 19:571-82. 2006
  7. ncbi Hyperglycemia in diabetics and non-diabetics: effect on the risk for and severity of pneumococcal pneumonia
    Adriana M Rueda
    Medical Service Infectious Disease Section, Michael E DeBakey Veterans Affairs Medical Center, Houston, TX 77030, USA
    J Infect 60:99-105. 2010
  8. ncbi Clinical characteristics of children with complicated pneumonia caused by Streptococcus pneumoniae
    Tina Q Tan
    Pediatric Infectious Diseases Sections of Northwestern University Medical School, Children s Memorial Hospital, Chicago, Illinois 60614, USA
    Pediatrics 110:1-6. 2002
  9. pmc Intrapulmonary administration of leukotriene B4 enhances pulmonary host defense against pneumococcal pneumonia
    Peter Mancuso
    Department of Environmental Health Sciences, School of Public Health, University of Michigan, SPHI A Tower, 109 S Observatory St, Ann Arbor, MI 48109 2029, USA
    Infect Immun 78:2264-71. 2010
  10. ncbi Pneumococcal pneumonia presenting with septic shock: host- and pathogen-related factors and outcomes
    C Garcia-Vidal
    Infectious Disease Department, Hospital Universitari de Bellvitge, Feixa Llarga s n, 08907 L Hospitalet de Llobregat, Barcelona, Spain
    Thorax 65:77-81. 2010

Detail Information

Publications337 found, 100 shown here

  1. ncbi Pathogenesis, treatment, and prevention of pneumococcal pneumonia
    Tom van der Poll
    Centre for Infection and Immunity Amsterdam, Centre for Experimental and Molecular Medicine, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    Lancet 374:1543-56. 2009
    ....
  2. ncbi A trial of a 9-valent pneumococcal conjugate vaccine in children with and those without HIV infection
    Keith P Klugman
    Medical Research Council, University of the Witwatersrand, National Institute for Communicable Diseases, Respiratory and Meningeal Pathogens Research Unit, Johannesburg, South Africa
    N Engl J Med 349:1341-8. 2003
    ..We evaluated the efficacy of a 9-valent pneumococcal conjugate vaccine in a randomized, double-blind study in Soweto, South Africa...
  3. pmc Association of serotype with risk of death due to pneumococcal pneumonia: a meta-analysis
    Daniel M Weinberger
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, USA
    Clin Infect Dis 51:692-9. 2010
    ..We evaluated whether risk of death due to IPD is a stable serotype-associated property across studies and then compared the pooled effect estimates with epidemiologic and biological correlates...
  4. ncbi Tissue-specific contributions of pneumococcal virulence factors to pathogenesis
    Carlos J Orihuela
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    J Infect Dis 190:1661-9. 2004
    ..We conclude that transitions between body sites require virulence determinants distinct from those involved in organ-specific replication...
  5. ncbi IL-10 is an important mediator of the enhanced susceptibility to pneumococcal pneumonia after influenza infection
    Koenraad F Van Der Sluijs
    Laboratory of Experimental Internal Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    J Immunol 172:7603-9. 2004
    Secondary pneumococcal pneumonia is a serious complication during and shortly after influenza infection...
  6. pmc Insights into the interaction between influenza virus and pneumococcus
    Jonathan A McCullers
    Department of Infectious Diseases, St Jude Children s Research Hospital, 332 N Lauderdale St, Memphis, TN 38105 2794, USA
    Clin Microbiol Rev 19:571-82. 2006
    ..Identification and exploration of the underlying mechanisms responsible for this synergism will provide targets for prevention and treatment using drugs and vaccines...
  7. ncbi Hyperglycemia in diabetics and non-diabetics: effect on the risk for and severity of pneumococcal pneumonia
    Adriana M Rueda
    Medical Service Infectious Disease Section, Michael E DeBakey Veterans Affairs Medical Center, Houston, TX 77030, USA
    J Infect 60:99-105. 2010
    We sought to determine whether poor glucose control among diabetics is associated with increased risk for pneumococcal pneumonia and whether elevated admitting plasma glucose (APG) levels are associated with increased severity of this ..
  8. ncbi Clinical characteristics of children with complicated pneumonia caused by Streptococcus pneumoniae
    Tina Q Tan
    Pediatric Infectious Diseases Sections of Northwestern University Medical School, Children s Memorial Hospital, Chicago, Illinois 60614, USA
    Pediatrics 110:1-6. 2002
    The frequency of children who are hospitalized with pneumococcal pneumonia complicated by necrosis, empyema/complicated parapneumonic effusion, and lung abscess seems to be increasing...
  9. pmc Intrapulmonary administration of leukotriene B4 enhances pulmonary host defense against pneumococcal pneumonia
    Peter Mancuso
    Department of Environmental Health Sciences, School of Public Health, University of Michigan, SPHI A Tower, 109 S Observatory St, Ann Arbor, MI 48109 2029, USA
    Infect Immun 78:2264-71. 2010
    ..The results of the current study in an animal model serve as a proof of concept for the potential utility of treatment with aerosolized LTB(4) as an immunostimulatory strategy in patients with bacterial pneumonia...
  10. ncbi Pneumococcal pneumonia presenting with septic shock: host- and pathogen-related factors and outcomes
    C Garcia-Vidal
    Infectious Disease Department, Hospital Universitari de Bellvitge, Feixa Llarga s n, 08907 L Hospitalet de Llobregat, Barcelona, Spain
    Thorax 65:77-81. 2010
    Host- and pathogen-related factors associated with septic shock in pneumococcal pneumonia are not well defined. The aim of this study was to identify risk factors for septic shock and to ascertain patient outcomes...
  11. ncbi Lethal synergism between influenza virus and Streptococcus pneumoniae: characterization of a mouse model and the role of platelet-activating factor receptor
    Jonathan A McCullers
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    J Infect Dis 186:341-50. 2002
    ..The model of lethal synergism will be a useful tool for exploring this and other mechanisms underlying viral-bacterial interactions...
  12. ncbi Alveolar macrophages have a protective antiinflammatory role during murine pneumococcal pneumonia
    Sylvia Knapp
    Laboratory of Experimental Internal Medicine, Department of Pathology, Academic Medical Center, University of Amsterdam, The Netherlands
    Am J Respir Crit Care Med 167:171-9. 2003
    ..To elucidate the in vivo contribution of AM to host defense against pneumococcal pneumonia, we depleted mice of AMs via pulmonary application of liposomal dichloromethylene-bisphosphonate (AM- mice)..
  13. ncbi Role of pneumolysin for the development of acute lung injury in pneumococcal pneumonia
    Martin Witzenrath
    Charite Universitatsmedizin Berlin, Department of Internal Medicine Infectious Diseases and Pulmonary Medicine, Berlin, Germany
    Crit Care Med 34:1947-54. 2006
    Acute respiratory failure is a significant complication of severe pneumococcal pneumonia. In a mouse model, we observed early-onset lung microvascular leakage after pulmonary infection with Streptococcus pneumoniae, and we hypothesized ..
  14. ncbi Bacteraemic pneumococcal pneumonia: impact of HIV on clinical presentation and outcome
    Charles Feldman
    Division of Pulmonology, Department of Medicine, Johannesburg Hospital, University of the Witwatersrand, Medical School, 7 York Road, Parktown 2193, Johannesburg, South Africa
    J Infect 55:125-35. 2007
    ..were to investigate the clinical and laboratory features, hospital course and outcome of patients with bacteraemic pneumococcal pneumonia, comparing HIV with non-HIV patients, as well as HIV patients from different parts of the world.
  15. ncbi Severity of pneumococcal pneumonia associated with genomic bacterial load
    Jordi Rello
    Critical Care Department, Hospital Universitari Joan XXIII, 43007 Tarragona, Spain
    Chest 136:832-40. 2009
    ..As viral load is useful in viral infections, we hypothesized that bacterial load may be associated with outcomes in patients with pneumococcal pneumonia.
  16. ncbi Sepsis severity predicts outcome in community-acquired pneumococcal pneumonia
    B Schaaf
    Medical Clinic III, University of Lubeck, Ratzeburger Allee 160, D 23538 Lubeck, Germany
    Eur Respir J 30:517-24. 2007
    ..value < or =60 mmHg) and age > or =65 yrs (CRB-65) score in 105 patients with community-acquired pneumococcal pneumonia. In addition, the influence of timing of the antimicrobial treatment on outcome was investigated...
  17. ncbi Molecular pathogenesis of pneumococcal pneumonia
    J A McCullers
    Department of Infectious Diseases, St Jude Children s, Research Hospital, 332 N Lauderdale Street, Memphis, TN 38105, USA
    Front Biosci 6:D877-89. 2001
    ..In this review we will discuss recent advances in our understanding of the pathogenesis of pneumonia due to S. pneumoniae, highlighting emerging themes common to other organisms such as Haemophilus influenzae and Neisseria meningitidis...
  18. pmc Functions and regulation of NF-kappaB RelA during pneumococcal pneumonia
    Lee J Quinton
    Molecular and Integrative Physiological Sciences Program, Harvard School of Public Health, Boston, MA 02115, USA
    J Immunol 178:1896-903. 2007
    ..Our results demonstrate that RelA is essential for the host defense response to pneumococcus in the lungs and that RelA in airway epithelial cells is primarily activated by TNF and IL-1...
  19. ncbi Efficacy of nine-valent pneumococcal conjugate vaccine against pneumonia and invasive pneumococcal disease in The Gambia: randomised, double-blind, placebo-controlled trial
    F T Cutts
    Medical Research Council Laboratories, Banjul, The Gambia
    Lancet 365:1139-46. 2005
    ..Pneumonia is estimated to cause 2 million deaths every year in children. Streptococcus pneumoniae is the most important cause of severe pneumonia. We aimed to assess the efficacy of a nine-valent pneumococcal conjugate vaccine in children...
  20. pmc Infection with human metapneumovirus predisposes mice to severe pneumococcal pneumonia
    Irena Kukavica-Ibrulj
    Research Center in Infectious Diseases of the Centre Hospitalier Universitaire de Québec and Laval University, Quebec City, Quebec, Canada
    J Virol 83:1341-9. 2009
    ..Prior infection with either hMPV or influenza A virus predisposes mice to severe pneumococcus infection...
  21. ncbi Of mice and men: innate immunity in pneumococcal pneumonia
    Esther Calbo
    Service of Internal Medicine, Infectious Disease Unit, Hospital Universitari Mutua de Terrassa, Plaza Dr Robert 5, 08221 Terrassa, Barcelona, Spain
    Int J Antimicrob Agents 35:107-13. 2010
    b>Pneumococcal pneumonia is characterised by an intense inflammatory response induced mainly by cell wall components of the bacterium...
  22. pmc The role of pneumolysin in pneumococcal pneumonia and meningitis
    R A Hirst
    Department of Infection, Inflamation and Immunity, University of Leicester, Leicester, UK
    Clin Exp Immunol 138:195-201. 2004
    ..One of the main toxins released from pneumococci is the membrane pore forming toxin pneumolysin. Here we review the extensive studies on the role of pneumolysin in the pathogenesis of pneumococcal diseases...
  23. ncbi Tumor suppressor CYLD regulates acute lung injury in lethal Streptococcus pneumoniae infections
    Jae Hyang Lim
    Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Immunity 27:349-60. 2007
    Streptococcus pneumoniae (S. pneumoniae) causes high early mortality in pneumococcal pneumonia, which is characterized by acute lung injury (ALI). The molecular mechanisms underlying ALI and the high early mortality remain unknown...
  24. ncbi Immunizations with pneumococcal surface protein A and pneumolysin are protective against pneumonia in a murine model of pulmonary infection with Streptococcus pneumoniae
    David E Briles
    Department of Microbiology, University of Alabama at Birmingham, USA
    J Infect Dis 188:339-48. 2003
    ..This may be the first demonstration that a proposed vaccine antigen can protect against pneumococcal pneumonia. The best protection was obtained by immunizing mice with a mixture of PspA and PdB, indicating that the ..
  25. ncbi Myeloid PTEN promotes inflammation but impairs bactericidal activities during murine pneumococcal pneumonia
    Gernot Schabbauer
    Department of Vascular Biology and Thrombosis Research, Center for Biomolecular Medicine and Pharmacology, Austrian Academy of Sciences, Vienna, Austria
    J Immunol 185:468-76. 2010
    ..PI3K activity dampened pulmonary inflammation, reduced neutrophil influx, and augmented phagocytic properties of macrophages, which ultimately resulted in decreased tissue injury and improved survival during murine pneumococcal pneumonia.
  26. pmc Contributions of pneumolysin, pneumococcal surface protein A (PspA), and PspC to pathogenicity of Streptococcus pneumoniae D39 in a mouse model
    Abiodun D Ogunniyi
    School of Molecular and Biomedical Science, University of Adelaide, Adelaide, South Australia 5005, Australia
    Infect Immun 75:1843-51. 2007
    ..These findings further demonstrate that the mechanism of pneumococcal pathogenesis is highly complex and multifactorial but ascribes a role for each of these virulence proteins, alone or in combination, in the process...
  27. ncbi Toll-like receptor 2 plays a role in the early inflammatory response to murine pneumococcal pneumonia but does not contribute to antibacterial defense
    Sylvia Knapp
    Laboratory of Experimental Internal Medicine, Department of Pathology, Tropical Medicine and AIDS, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Immunol 172:3132-8. 2004
    ..These data suggest that TLR2 plays a limited role in the innate immune response to pneumococcal pneumonia, and that additional pattern recognition receptors likely are involved in host defense against this common ..
  28. ncbi The impact of a 9-valent pneumococcal conjugate vaccine on the public health burden of pneumonia in HIV-infected and -uninfected children
    Shabir A Madhi
    National Health Laboratory Service, University of the Witwatersrand, Johannesburg, South Africa
    Clin Infect Dis 40:1511-8. 2005
    Pneumococcal conjugate vaccine (PnCV) may be used as a probe to define the burden of pneumococcal disease and better characterize the clinical presentation of pneumococcal pneumonia.
  29. pmc Both influenza-induced neutrophil dysfunction and neutrophil-independent mechanisms contribute to increased susceptibility to a secondary Streptococcus pneumoniae infection
    Lynnelle A McNamee
    Veterinary Molecular Biology Department, Montana State University, 960 Technology Blvd, Bozeman, MT 59718, USA
    Infect Immun 74:6707-21. 2006
    ..Thus, an influenza infection of 6 days increases susceptibility to S. pneumoniae by both suppression of neutrophil function and by neutrophil-independent mechanisms such as enhanced cytokine production...
  30. ncbi The innate immune response to pneumococcal lung infection: the untold story
    Aras Kadioglu
    Department of Infection, Immunity and Inflammation, Medical Sciences Building, University of Leicester, Leicester LE1 9HN, U K
    Trends Immunol 25:143-9. 2004
  31. ncbi Severe pneumococcal pneumonia in previously healthy children: the role of preceding influenza infection
    K L O'Brien
    Respiratory Diseases Branch, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA
    Clin Infect Dis 30:784-9. 2000
    An outbreak of severe pneumococcal pneumonia among children occurred in Iowa from November 1995 through January 1996. An associated outbreak of influenza disease was predominantly caused by influenza A (H1N1) for the first time since 1989...
  32. ncbi Leptin corrects host defense defects after acute starvation in murine pneumococcal pneumonia
    Peter Mancuso
    Department of Environmental Health Sciences SPH II, University of Michigan, 1420 Washington Heights, Ann Arbor, MI 48109 2029, USA
    Am J Respir Crit Care Med 173:212-8. 2006
    ..Previously, we employed leptin-deficient (ob/ob) mice to identify an important role for leptin in the host defense against Klebsiella pneumonia...
  33. pmc Galectin-3 reduces the severity of pneumococcal pneumonia by augmenting neutrophil function
    Sarah L Farnworth
    Centre for Inflammation Research, The Queen s Medical Research Institute, University of Edinburgh, Edinburgh EH16 4TJ, UK
    Am J Pathol 172:395-405. 2008
    ..bacteremia and lung damage compared to wild-type mice and that galectin-3 reduces the severity of pneumococcal pneumonia in part by augmenting neutrophil function...
  34. ncbi Decline in pneumonia admissions after routine childhood immunisation with pneumococcal conjugate vaccine in the USA: a time-series analysis
    Carlos G Grijalva
    Department of Preventive Medicine, Vanderbilt University School of Medicine, Nashville, TN 37212, USA
    Lancet 369:1179-86. 2007
    ..We therefore assessed the effect of the programme on rates of all-cause and pneumococcal pneumonia admissions.
  35. ncbi Toll-like receptor 2 does not contribute to host response during postinfluenza pneumococcal pneumonia
    Mark C Dessing
    Center for Infection and Immunity Amsterdam CINIMA, Laboratory of Experimental Immunology, Department of Pulmonology, University of Amsterdam, The Netherlands
    Am J Respir Cell Mol Biol 36:609-14. 2007
    ..the objective of this study was to determine the role of TLR2 in the host response to postinfluenza pneumococcal pneumonia. TLR2 knockout (KO) and wild-type (WT) mice were infected intranasally with influenza A virus...
  36. pmc The scavenger receptor MARCO is required for lung defense against pneumococcal pneumonia and inhaled particles
    Mohamed Arredouani
    Physiology Program, Harvard School of Public Health, 665 Huntington Ave, SPH II, Rm 221, Boston, MA 02115, USA
    J Exp Med 200:267-72. 2004
    ..In a murine model of pneumococcal pneumonia, MARCO(-/-) mice displayed an impaired ability to clear bacteria from the lungs, increased pulmonary ..
  37. ncbi Treatment and outcomes for patients with bacteremic pneumococcal pneumonia
    Catherine M Berjohn
    Drexel School of Public Health, Philadelphia, PA, USA
    Medicine (Baltimore) 87:160-6. 2008
    ..length of stay, and time to stability, for patients hospitalized with community-acquired bacteremic pneumococcal pneumonia. We conducted a retrospective cohort study in 43 hospitals in the Southeastern Pennsylvania region from ..
  38. ncbi Clinical outcomes of bacteremic pneumococcal pneumonia in the era of antibiotic resistance
    J F Moroney
    Respiratory Diseases Branch, Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Clin Infect Dis 33:797-805. 2001
    Limited data are available about the impact of antimicrobial resistance on clinical outcomes in cases of pneumococcal pneumonia. This was studied in 146 persons hospitalized with invasive pneumonia due to Streptococcus pneumoniae (minimum ..
  39. ncbi Classical and latent class analysis evaluation of sputum polymerase chain reaction and urine antigen testing for diagnosis of pneumococcal pneumonia in adults
    Jay C Butler
    Respiratory Diseases Branch, Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    J Infect Dis 187:1416-23. 2003
    Diagnosis of pneumococcal pneumonia is complicated by the lack of a diagnostic reference standard that is highly sensitive and specific...
  40. ncbi World Health Organisation definition of "radiologically-confirmed pneumonia" may under-estimate the true public health value of conjugate pneumococcal vaccines
    Shabir A Madhi
    University of the Witwatersrand Medical Research Council, Respiratory and Meningeal Pathogens Research Unit, South Africa
    Vaccine 25:2413-9. 2007
    ..vaccine (PCV) in preventing pneumonia would only be appreciated if the tool used for measuring "pneumococcal pneumonia" had good sensitivity...
  41. pmc Socioeconomic risk factors for bacteraemic pneumococcal pneumonia in adults
    J H Flory
    Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia PA, USA
    Epidemiol Infect 137:717-26. 2009
    Demographic and clinical risk factors are important in guiding vaccination policy for pneumococcal pneumonia. We present data on these variables from a population-based surveillance network covering adult bacteraemic pneumococcal ..
  42. ncbi The contribution of specific pneumococcal serogroups to different disease manifestations: implications for conjugate vaccine formulation and use, part II
    W P Hausdorff
    Wyeth Lederle Vaccines, West Henrietta and Pearl River, NY 14586, USA
    Clin Infect Dis 30:122-40. 2000
    ..These analyses indicate that pneumococcal conjugate vaccines could potentially prevent a substantial proportion of episodes of bacteremic disease, pneumonia, meningitis, and otitis media, especially in young children...
  43. ncbi A comparative study of bacteremic and non-bacteremic pneumococcal pneumonia
    Francisco Jover
    Infectious Diseases Division, Internal Medicine Department, Hospital of San Juan, Alicante, Spain
    Eur J Intern Med 19:15-21. 2008
    Few attempts have been made to compare bacteremic and non-bacteremic pneumococcal pneumonia, mainly because it is difficult to gain agreement on which cases represent non-bacteremic pneumococcal pneumonia...
  44. ncbi Clinical outcomes of pneumococcal pneumonia caused by antibiotic-resistant strains in asian countries: a study by the Asian Network for Surveillance of Resistant Pathogens
    Jae Hoon Song
    Division of Infectious Diseases, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    Clin Infect Dis 38:1570-8. 2004
    To evaluate the clinical outcomes of pneumococcal pneumonia caused by antibiotic-resistant strains in Asian countries, we performed a prospective observational study of 233 cases of adult pneumococcal pneumonia in 9 Asian countries from ..
  45. ncbi Penicillins for treatment of pneumococcal pneumonia: does in vitro resistance really matter?
    Lance R Peterson
    Evanston Northwestern Healthcare Research Institute, Division of Microbiology, Department of Pathology and Laboratory Medicine, Northwestern University, Evanston, IL, USA
    Clin Infect Dis 42:224-33. 2006
    ..In particular, resistance of Streptococcus pneumoniae to beta-lactam antibiotic therapy has assumed a prominent role in the evolution of guidelines for the initial treatment of respiratory tract infection...
  46. ncbi Decreased alveolar macrophage apoptosis is associated with increased pulmonary inflammation in a murine model of pneumococcal pneumonia
    Helen M Marriott
    School of Medicine and Biomedical Sciences, University of Sheffield, Beech Hill Road, Sheffield S10 2RX, United Kingdom
    J Immunol 177:6480-8. 2006
    ..infection, we have explored the role of macrophage apoptosis in regulating inflammatory responses during pneumococcal pneumonia, using inducible NO synthase (iNOS)-deficient mice...
  47. ncbi Pneumococcal pneumonia: potential for diagnosis through a urinary metabolic profile
    Carolyn M Slupsky
    Department of Medicine, Magnetic Resonance Diagnostic Centre, University of Alberta, Edmonton, Alberta, Canada
    J Proteome Res 8:5550-8. 2009
    ..We found that the urinary metabolomic profile for pneumococcal pneumonia was significantly different from the profiles for viral and other bacterial forms of pneumonia...
  48. ncbi An outbreak of pneumococcal pneumonia among military personnel at high risk: control by low-dose azithromycin postexposure chemoprophylaxis
    Jose L Sanchez
    Epidemiology Services, Directorate of Epidemiology and Disease Surveillance, U S Army Center for Health Promotion and Preventive Medicine, 5158 Blackhawk Road, Aberdeen Proving Ground, MD 21010 5403, USA
    Mil Med 168:1-6. 2003
    In the winter of 1998-1999 an outbreak of pneumococcal pneumonia occurred among Ranger students undergoing high-intensity training. Thirty pneumonia cases (attack rate = 12.6%) were identified among a group of 239 students...
  49. pmc Usefulness of urinary antigen detection by an immunochromatographic test for diagnosis of pneumococcal pneumonia in children
    J Dominguez
    Servei de Microbiologia, Hospital Universitari Germans Trias i Pujol, Universitat Autonoma de Barcelona, Barcelona, Spain
    J Clin Microbiol 41:2161-3. 2003
    ..immunochromatographic assay detecting pneumococcal antigen in urine samples from children diagnosed with pneumococcal pneumonia. The sensitivity and specificity of the immunochromatographic test with nonconcentrated urine (NCU) were ..
  50. ncbi Usefulness of real-time PCR for lytA, ply, and Spn9802 on plasma samples for the diagnosis of pneumococcal pneumonia
    G Abdeldaim
    Department of Clinical Microbiology, Uppsala University Hospital, Uppsala, Sweden
    Clin Microbiol Infect 16:1135-41. 2010
    ..We conclude that Spn9802 and lytA PCRs may be useful for the rapid detection of bacteraemic pneumococcal pneumonia, whereas ply PCR is not specific enough for routine use and blood PCR with small plasma volumes is not ..
  51. pmc Reactive oxygen species regulate neutrophil recruitment and survival in pneumococcal pneumonia
    Helen M Marriott
    Section of Infection and Inflammation, School of Medicine and Biomedical Sciences, University of Sheffield, LU107, Royal Hallamshire Hospital, Glossop Road, Sheffield, S10 2JF, UK
    Am J Respir Crit Care Med 177:887-95. 2008
    ..The relative importance of each role remains poorly defined in community-acquired pneumonia...
  52. ncbi Bacteremic pneumococcal pneumonia in HIV-seropositive and HIV-seronegative adults
    C Feldman
    Department of Medicine, Hillbrow Hospital, University of the Witwatersrand, Johannesburg, South Africa
    Chest 116:107-14. 1999
    To compare the demographic, clinical, laboratory, and microbiological data, and the hospital course and outcome of HIV-seropositive and HIV-seronegative adults with bacteremic pneumococcal pneumonia.
  53. pmc Expression of the 1918 influenza A virus PB1-F2 enhances the pathogenesis of viral and secondary bacterial pneumonia
    Julie L McAuley
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Cell Host Microbe 2:240-9. 2007
    ..These findings help explain both the unparalleled virulence of the 1918 strain and the high incidence of fatal pneumonia during the pandemic...
  54. ncbi Streptococcus pneumoniae-associated human macrophage apoptosis after bacterial internalization via complement and Fcgamma receptors correlates with intracellular bacterial load
    Farzana Ali
    Division of Genomic Medicine, University of Sheffield School of Medicine and Biomedical Sciences, Sheffield, United Kingdom
    J Infect Dis 188:1119-31. 2003
    ..A dynamic interaction between live intracellular bacteria and the host cell is necessary for induction of apoptosis in MDMs, and induction of apoptosis contributes to the host defense against S. pneumoniae...
  55. ncbi TREM-1 activation alters the dynamics of pulmonary IRAK-M expression in vivo and improves host defense during pneumococcal pneumonia
    Heimo Lagler
    Department of Medicine I, Division of Infectious Diseases and Tropical Medicine, Medical University Vienna, Vienna, Austria
    J Immunol 183:2027-36. 2009
    ..To determine the function of TREM-1 in pneumococcal pneumonia, we first established TREM-1 up-regulation in infected lungs and human plasma together with augmented ..
  56. pmc Clinical presentation, processes and outcomes of care for patients with pneumococcal pneumonia
    J A Brandenburg
    School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    J Gen Intern Med 15:638-46. 2000
    OBJECTIVE: To describe the presentation, resolution of symptoms, processes of care, and outcomes of pneumococcal pneumonia, and to compare features of the bacteremic and nonbacteremic forms of this illness...
  57. ncbi Mucosal vaccination with a multicomponent adenovirus-vectored vaccine protects against Streptococcus pneumoniae infection in the lung
    Maria T Arévalo
    Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
    FEMS Immunol Med Microbiol 55:346-51. 2009
    ..pneumoniae strain D39 colonization in mouse lungs. Taken together, these data demonstrate the feasibility of developing a mucosal vaccine against S. pneumoniae using recombinant adenoviruses for antigen delivery...
  58. ncbi Pneumococcal pneumonia and influenza: a deadly combination
    Keith P Klugman
    Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA
    Vaccine 27:C9-C14. 2009
    ..Vaccination with PCV for children and pneumococcal polysaccharide vaccine for adults should be considered essential to pandemic influenza preparedness...
  59. pmc Role of pneumococcal surface protein C in nasopharyngeal carriage and pneumonia and its ability to elicit protection against carriage of Streptococcus pneumoniae
    Priya Balachandran
    Department of Microbiology, The University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Infect Immun 70:2526-34. 2002
    ..This latter finding strongly indicates that pneumococci are actively metabolizing and growing while in the nasopharynx...
  60. ncbi Activation of neutrophils and inhibition of the proinflammatory cytokine response by endogenous granulocyte colony-stimulating factor in murine pneumococcal pneumonia
    Sylvia Knapp
    Laboratory of Experimental Internal Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Infect Dis 189:1506-15. 2004
    ..The present study sought to determine the role of endogenous G-CSF in host defense against pneumococcal pneumonia. Patients with unilateral community-acquired pneumonia demonstrated elevated concentrations of G-CSF in ..
  61. ncbi Interleukin-6 gene-deficient mice show impaired defense against pneumococcal pneumonia
    T van der Poll
    Department of Surgery, Cornell University Medical College, New York, New York, USA
    J Infect Dis 176:439-44. 1997
    ..pneumoniae colonies (P < .05). IL-6-/- mice died significantly earlier from pneumococcal pneumonia than did IL-6+/+ mice (P < .05)...
  62. ncbi The association between pneumococcal pneumonia and acute cardiac events
    Daniel M Musher
    Medical Care Line, Infectious Disease Section, Michael E DeBakey Veterans Affairs Medical Center, Houston, TX 77030, USA
    Clin Infect Dis 45:158-65. 2007
    ..We sought to determine the incidence of such events in patients who were hospitalized for community-acquired pneumococcal pneumonia.
  63. pmc Prevention of influenza and pneumococcal pneumonia in Canadian long-term care facilities: how are we doing?
    C G Stevenson
    Department of Microbiology, Mount Sinai Hospital, University of Toronto, Toronto, Ont
    CMAJ 164:1413-9. 2001
    Influenza and pneumococcal pneumonia are serious health problems among elderly people and a major cause of death in long-term care facilities...
  64. ncbi Identification of a detrimental role for NK cells in pneumococcal pneumonia and sepsis in immunocompromised hosts
    Alison R Kerr
    Division of Infection and Immunity, IBLS, Joseph Black Building, University of Glasgow, Glasgow G12 8QQ, UK
    Microbes Infect 7:845-52. 2005
    ..Overall results indicate that elevated NK cell activity during pneumococcal pneumonia amplifies pulmonary and systemic inflammation, increases bacteraemia and results in poor outcome.
  65. ncbi Drug-resistant pneumococcal pneumonia: clinical relevance and approach to management
    J D Fuller
    Department of Microbiology, Toronto Medical Laboratories and Mount Sinai Hospital, University of Toronto, 600 University Avenue, M5G 1X5, Toronto, Ontario, Canada
    Eur J Clin Microbiol Infect Dis 24:780-8. 2005
    ..This will allow clinicians to better define optimal therapy for patients with community-acquired pneumonia...
  66. ncbi Monotherapy may be suboptimal for severe bacteremic pneumococcal pneumonia
    G W Waterer
    Department of Medicine, University of Western Australia, Royal Perth Hospital, GPO Box X2213, Perth 6847, Western Australia
    Arch Intern Med 161:1837-42. 2001
    BACKGROUND: Although monotherapy for pneumococcal pneumonia is standard, a survival benefit of combination beta-lactam and macrolide therapy has been suggested...
  67. pmc Prospective study to determine clinical relevance of detection of pneumococcal DNA in sera of children by PCR
    R Dagan
    Pediatric Infectious Disease Unit, Soroka University Medical Center, Ben Gurion University of the Negev, Beer Sheva, Israel
    J Clin Microbiol 36:669-73. 1998
    ....
  68. pmc Induction of pro- and anti-inflammatory molecules in a mouse model of pneumococcal pneumonia after influenza
    Matthew W Smith
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, TN, USA
    Comp Med 57:82-9. 2007
    ..Mortality correlated with the development of pneumonia and lung inflammation but not with bacteremia. This model has the potential to help us understand the pathogenesis of severe lung infections...
  69. ncbi Diagnostic value of microscopic examination of Gram-stained sputum and sputum cultures in patients with bacteremic pneumococcal pneumonia
    Daniel M Musher
    Infectious Disease Section, Medical Service, Veterans Affairs Medical Center, Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
    Clin Infect Dis 39:165-9. 2004
    ..We analyzed the sensitivity of these techniques in 105 patients with pneumococcal pneumonia proven by blood culture...
  70. ncbi Therapeutic options for pneumococcal pneumonia in Turkey
    Serkan Oncu
    Department of Infectious Diseases and Clinical Microbiology, Adnan Menderes University Medical Faculty, Aydin, Turkey
    Clin Ther 27:674-83. 2005
    ..Community-acquired pneumonia (CAP) is a leading cause of morbidity and mortality worldwide. Streptococcus pneumoniae continues to be the most important causative agent in CAP...
  71. pmc Potential role for mucosally active vaccines against pneumococcal pneumonia
    Kondwani C Jambo
    Malawi Liverpool Wellcome Trust Clinical Research Programme, P O Box 30096, Chichiri, Blantyre, Malawi
    Trends Microbiol 18:81-9. 2010
    b>Pneumococcal pneumonia is a life-threatening disease with high mortality and morbidity among children under 5 years of age, the elderly and immunocompromised individuals worldwide...
  72. pmc Initial and subsequent response to pneumococcal polysaccharide and protein-conjugate vaccines administered sequentially to adults who have recovered from pneumococcal pneumonia
    Daniel M Musher
    Michael E DeBakey Veterans Affairs Medical Center, Houston, Texas 77030, USA
    J Infect Dis 198:1019-27. 2008
    ..We studied PPV, protein-conjugate pneumococcal vaccine (PCV), and immunologic "priming" with PCV followed by "boosting" with PPV in adults who had recovered from pneumococcal pneumonia.
  73. pmc Pneumococcal behavior and host responses during bronchopneumonia are affected differently by the cytolytic and complement-activating activities of pneumolysin
    Rania Jounblat
    Department of Microbiology and Immunology, University of Leicester, University Road, Leicester, LE1 9HN, UK
    Infect Immun 71:1813-9. 2003
    ..The complement-activating activity of pneumolysin affected the accumulation of T cells, whereas the toxin's cytolytic activity influenced neutrophil recruitment into lung tissue...
  74. ncbi Severity of illness scoring systems in patients with bacteraemic pneumococcal pneumonia: implications for the intensive care unit care
    C Feldman
    Division of Pulmonology, Department of Medicine, Charlotte Maxeke Johannesburg Academic Hospital and University of the Witwatersrand, Johannesburg, South Africa
    Clin Microbiol Infect 15:850-7. 2009
    ..and the Pitt Bacteraemia score (PBS) in evaluating severity of illness in 766 patients with bacteraemic pneumococcal pneumonia. We evaluated the sensitivity and specificity, the positive predictive value (PPV) and the negative ..
  75. pmc Pulmonary dendritic cells and alveolar macrophages are regulated by gammadelta T cells during the resolution of S. pneumoniae-induced inflammation
    A C Kirby
    Immunology and Infection Unit, Department of Biology, University of York and Hull York Medical School, UK
    J Pathol 212:29-37. 2007
    ..These findings support a model whereby expansion of gammadelta T cells helps restore mononuclear phagocyte numbers to homeostatic levels, protecting the lung from the consequences of inappropriate inflammation...
  76. ncbi Bacteremic pneumococcal pneumonia associated with macrolide failure
    J Dylewski
    Department of Medicine, St Mary s Hospital, 3830 Lacombe, Montreal, Quebec H3T 1M5, Canada
    Eur J Clin Microbiol Infect Dis 25:39-42. 2006
    ..pneumoniae is clinically important. Reported here are two cases of community-acquired pneumonia caused by S. pneumoniae, one of which was fatal, that failed to respond to clarithromycin...
  77. ncbi Rapid urinary antigen test for diagnosis of pneumococcal community-acquired pneumonia in adults
    M A Marcos
    Dept of Microbiology, Institute of Infections and Immunology, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, Universitat de Barcelona, Barcelona, Spain
    Eur Respir J 21:209-14. 2003
    ..S. pneumoniae antigen was detected in all of the 68 (100%) patients tested with definitive pneumococcal pneumonia. In five of these cases ICT was only positive when it had been performed on the patients. The S...
  78. ncbi Bacteraemic pneumococcal pneumonia in COPD patients: better outcomes than expected
    E Calbo
    Infection Control Department, Infectious Disease Unit, Service of Internal Medicine, Hospital Universitari Mutua de Terrassa, Plaza Dr Robert 5, 08221 Terrassa, Barcelona, Spain
    Eur J Clin Microbiol Infect Dis 28:971-6. 2009
    The purpose of the study was to compare the clinical characteristics and outcomes of bacteraemic pneumococcal pneumonia (BPP) in chronic obstructive pulmonary disease (COPD) and non-COPD patients. A case-control study was conducted...
  79. ncbi Effect of prior pneumococcal vaccination on clinical outcome of hospitalized adults with community-acquired pneumococcal pneumonia
    A Mykietiuk
    Infectious Disease Service, Institut d Investigacio Biomedica de Bellvitge, Hospital Universitari de Bellvitge, University of Barcelona, Feixa Llarga s n, L Hospitalet, 08907, Barcelona, Spain
    Eur J Clin Microbiol Infect Dis 25:457-62. 2006
    ..vaccination on the clinical outcome of 554 consecutive hospitalized adults with community-acquired pneumococcal pneumonia from 1995 to 2004, 61 of whom had been vaccinated in the 5 years before admission...
  80. ncbi Pneumococcal serogroups and serotypes in severe pneumococcal pneumonia in Belgian children: theoretical coverage of the 7-valent and 9-valent pneumococcal conjugate vaccines
    Iris De Schutter
    Department of Pediatrics, Pediatric Respiratory Medicine, Cystic Fibrosis Clinic and Infectiology, Brussels, Belgium
    Pediatr Pulmonol 41:765-70. 2006
    ..Although the causative pneumococcal serotypes of invasive diseases are already extensively studied, few data are available about the pneumococcal serotypes additionally isolated from broncho-alveolar lavage samples in childhood pneumonia...
  81. pmc Mannose-binding lectin does not act as an acute-phase reactant in adults with community-acquired pneumococcal pneumonia
    M Perez-Castellano
    Service of Immunology, Hospital Son Dureta, 07198 Palma de Mallorca, Spain
    Clin Exp Immunol 145:228-34. 2006
    ..of this work was to study the role of mannose-binding lectin (MBL) and C-reactive protein (CRP) in pneumococcal pneumonia, to determine whether MBL acts as an acute-phase reactant and whether the severity of the disease ..
  82. ncbi Population-based impact of pneumococcal conjugate vaccine in young children
    Katherine A Poehling
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2637, USA
    Pediatrics 114:755-61. 2004
    ..To determine the population impact of pneumococcal conjugate vaccine (PCV) on pneumococcal-related diseases, including pneumonia and otitis media...
  83. ncbi (1)H MRI of pneumococcal pneumonia in a murine model
    Pasquina Marzola
    NMR Laboratory, University of Verona, Verona Italy
    J Magn Reson Imaging 22:170-4. 2005
    To detect and quantify pulmonary lesions due to pneumococcal pneumonia in a murine model by (1)H MRI.
  84. pmc Novel murine model of pneumococcal pneumonia: use of temperature as a measure of disease severity to compare the efficacies of moxifloxacin and levofloxacin
    Darrin J Bast
    Toronto Centre for Antimicrobial Research and Evaluation, Room 1483, Mount Sinai Hospital, 600 University Ave, Toronto, Ontario M5G 1X5, Canada
    Antimicrob Agents Chemother 48:3343-8. 2004
    ..thermometer was used to evaluate disease severity and predict imminent death in a murine model of pneumococcal pneumonia. We showed that a decrease in temperature was associated with increasing severity of disease and ..
  85. ncbi Effect of pneumococcal vaccination: a comparison of vaccination rates in patients with bacteremic and nonbacteremic pneumococcal pneumonia
    Daniel M Musher
    Infectious Disease Section, Medical Service, Michael E DeBakey Veterans Affairs Medical Center, Houston, TX 77030, USA
    Clin Infect Dis 43:1004-8. 2006
    ..Despite the widespread acceptance of the 23-valent pneumococcal capsular polysaccharide vaccine (PPV), its protective effect continues to be disputed. We describe a novel approach to examine the protective effect of this vaccine...
  86. ncbi Quinolone resistance among pneumococci: therapeutic and diagnostic implications
    Donald E Low
    Department of Microbiology, Toronto Medical Laboratories Mount Sinai Hospital, University of Toronto, Toronto, Canada
    Clin Infect Dis 38:S357-62. 2004
    ....
  87. pmc Genotypes and related factors reflecting macrolide resistance in pneumococcal pneumonia infections in Japan
    Rie Isozumi
    Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, 54, Kawahara, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    J Clin Microbiol 45:1440-6. 2007
    ..By multivariate analysis, oxygen saturation of <90% on admission increased the risk for ermB-positive pneumococcal pneumonia (odds ratio [OR]=11.1; 95% confidence interval [CI]=1.30 to 95.0; P=0...
  88. ncbi The receptor for advanced glycation end products impairs host defense in pneumococcal pneumonia
    Marieke A D van Zoelen
    Center for Infection and Immunity Amsterdam, Germany
    J Immunol 182:4349-56. 2009
    ..These data suggest that RAGE plays a detrimental role in the host response to S. pneumoniae pneumonia by facilitating the bacterial growth and dissemination and concurrently enhancing the pulmonary inflammatory and procoagulant response...
  89. ncbi [Invasive pneumococcal pneumonia in children 0-24 months old: does bacterial resistance affect outcome]
    M C Pírez García
    Clinica Pediatrica, Hospital Pediátrico, Centro Hospitalario Pereira Rossell, Montevideo, Uruguay
    An Pediatr (Barc) 69:205-9. 2008
    ..S. pneumoniae is the most frequent agent. The disease is more severe in children less than two years old. The relationship between pneumococcal penicillin resistance and outcome is still an unresolved problem...
  90. pmc Age-associated inflammation and toll-like receptor dysfunction prime the lungs for pneumococcal pneumonia
    Ernesto Hinojosa
    Department of Microbiology and Immunology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
    J Infect Dis 200:546-54. 2009
    ..We sought to determine whether aging and chronic inflammation were associated with increased pIgR and PAFr levels in the lungs and increased susceptibility to S. pneumoniae infection...
  91. ncbi Impact of penicillin susceptibility on medical outcomes for adult patients with bacteremic pneumococcal pneumonia
    J P Metlay
    Veterans Affairs Medical Center and University of Pennsylvania School of Medicine, Philadelphia, PA, 19104, USA
    Clin Infect Dis 30:520-8. 2000
    The impact of penicillin susceptibility on medical outcomes for adult patients with bacteremic pneumococcal pneumonia was evaluated in a retrospective cohort study conducted during population-based surveillance for invasive pneumococcal ..
  92. ncbi Bacteremic pneumococcal pneumonia in children
    P Toikka
    Department of Pediatrics, Turku University Hospital, Finland
    Clin Infect Dis 29:568-72. 1999
    We carried out a nationwide retrospective study on bacteremic pneumococcal pneumonia diagnosed from 1985 to 1994 in Finland. The records of 85 children were reviewed for symptoms, signs, laboratory data, and response to antibiotic therapy...
  93. ncbi Determinants of outcome in patients with bacteraemic pneumococcal pneumonia: importance of early adequate treatment
    Jose Garnacho-Montero
    Intensive Care Unit, Hospital Universitario Virgen del Rocio, Seville, Spain
    Scand J Infect Dis 42:185-92. 2010
    ..53, 95% CI 0.29-0.95; p = 0.033). Administration of adequate antimicrobial therapy within 4 h of arrival is a critical determinant of survival in patients with bacteraemic pneumococcal CAP...
  94. ncbi Hemolytic uremic syndrome associated with pneumococcal pneumonia in Taiwan
    Yu Hsuan Huang
    Division of Pediatric Pulmonology, Department of Pediatrics, Chang Gung Children s Hospital, Chang Gung University, College of Medicine, 5, Fu Hsin Street, Taoyuan, Taiwan
    Eur J Pediatr 165:332-5. 2006
    ..Three patients had leukopenia as the initial presentation. All seven patients had pneumococcal pneumonia complicating with empyema, and two of them received decortication via video-assisted thoracoscopic surgery...
  95. pmc The role of surfactant protein D in the colonisation of the respiratory tract and onset of bacteraemia during pneumococcal pneumonia
    R Jounblat
    MRC Immunochemistry Unit, University of Oxford, South Parks Road, Oxford, OX1 3QU, UK
    Respir Res 6:126. 2005
    ..Our data provides evidence that SP-D has a significant role to play in the clearance of pneumococci during the early stages of infection in both pulmonary sites and blood...
  96. ncbi Cell-specific interleukin-15 and interleukin-15 receptor subunit expression and regulation in pneumococcal pneumonia--comparison to chlamydial lung infection
    Andreas C Hocke
    Charite Universitatsmedizin Berlin, Department of Internal Medicine, Infectious and Respiratory Diseases, Chariteplatz 1, 10117 Berlin, Germany
    Cytokine 38:61-73. 2007
    ..The induction of pneumococcal pneumonia but not the infection with Chlamydophila pneumoniae evoked a significant up-regulation of IL-15 on ..
  97. ncbi Rapid diagnosis of pneumococcal pneumonia in adults using the Binax NOW Streptococcus pneumoniae urinary antigen test
    Bram M W Diederen
    Int J Infect Dis 11:284-5. 2007
  98. ncbi Pneumococcal pneumonia in hospitalized Uruguayan children and potential prevention with different vaccine formulations
    Maria Hortal
    National Child Health Program, Ministry of Health, Children s Hospital, Montevideo, Uruguay
    J Pediatr 152:850-3. 2008
    ..To provide information on pneumococcal pneumonias, on their associated serotypes, and to estimate the coverage potentially afforded by antipneumococcal vaccines...
  99. pmc Leptin improves pulmonary bacterial clearance and survival in ob/ob mice during pneumococcal pneumonia
    A Hsu
    Department of Environmental Health Sciences, Ann Arbor, MI, USA
    Clin Exp Immunol 150:332-9. 2007
    ..In this report we assessed the impact of chronic leptin deficiency, using ob/ob mice, on pneumococcal pneumonia and examined whether restoring circulating leptin to physiological levels in vivo could improve host ..
  100. ncbi [Severe pneumococcal infections: virulence aspects]
    E Varon
    centre national de référence des pneumocoques, Hopital Europeen Georges Pompidou, 20 40, rue Leblanc, 75908 Paris, France
    Arch Pediatr 8:752s-756s. 2001
    ..These factors contribute together to the colonization, protection from phagocytosis, invasion, inflammatory response, and tissue damage...
  101. ncbi [Bacteremic pneumococcal pneumonia in 45 immunocompromised hospitalized adults]
    Maria Luisa Rioseco
    Laboratorio de Microbiologia, Servicio de Medicina, Hospital de Puerto Montt
    Rev Med Chil 132:588-94. 2004
    The presence of bacteremia during a pneumococcal pneumonia is a sign of bad prognosis.

Research Grants56

  1. Cytokine-stimulated systemic defenses during pneumococcal pneumonia
    Joseph P Mizgerd; Fiscal Year: 2013
    ..This new knowledge will guide further studies aiming to identify people who are especially susceptible and bacteria that are especially virulent, in order to better prevent and treat pneumococcal infections. ..
  2. Influence of Macrophage NF-kB Activation on the Outcome of Pneumococcal Pneumonia
    FADIE THOMAS COLEMAN; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Pneumococcal pneumonia is a leading cause of infection-related deaths in the United States...
  3. Plasma Gelsolin and Host Defense After Lung Injury
    Lester Kobzik; Fiscal Year: 2013
    ..These studies will use a model of non-lethal influenza with enhanced susceptibility to secondary pneumococcal pneumonia during the resolution phase...
  4. VARIABLE GENE DEFECTS AND PNEUMOCOCCAL SUSCEPTIBILITY
    Liise Anne Pirofski; Fiscal Year: 2010
    ..of the proposal is on the relationship between the immune status of the host and Ab protection against pneumococcal pneumonia. Pneumococcal pneumonia is the leading cause of community acquired pneumonia in the U.S. and globally...
  5. Race and Ethnicity in Vaccination for Influenza in Vulnerable Elderly (REVIVE)
    NANCY JEAN KUPKA; Fiscal Year: 2011
    ..DESCRIPTION (provided by applicant): Immunization is an effective strategy to reduce illness and death from pneumococcal pneumonia and influenza, yet these two illnesses are the leading cause of death from preventable disease among older ..
  6. Proteoglycans in Lung Innate Immunity and Host Defense
    Pyong Woo Park; Fiscal Year: 2012
    ..central goal of this proposal is to define how proteoglycans modulate the lung innate immune response in pneumococcal pneumonia. Streptococcus pneumoniae, the pneumococcus, is the most common causative agent of community-acquired ..
  7. Case-PNG Global Infectious Disease Research Training Program (D43)
    Peter A Zimmerman; Fiscal Year: 2013
    ..Malaria and pneumococcal pneumonia rank among the top 3 causes of out-patient visits to health centers, hospital admissions and death...
  8. IMMUNOLOGY OF BACTERIAL PNEUMONIA IN HTLV-II INFECTION
    GARY JARVIS; Fiscal Year: 2002
    ..creating immune dysfunction in these cells which are known to be critical for natural protection against pneumococcal pneumonia, the most common cause of bacterial pneumonia in individuals with immune dysfunction...
  9. Alcohol and Impairment of the Granulopoietic Response to Pneumonia
    Ping Zhang; Fiscal Year: 2010
    ..preliminary data show that alcohol suppresses granulopoietic progenitor cell proliferation in response to pneumococcal pneumonia or G-CSF stimulation...
  10. Smoking and Ethanol-Induced Defects in Pneumonia Defense
    MARTHA GENTRY NIELSEN; Fiscal Year: 2004
    ..model to study the compounding effects of cigarette smoke and alcohol abuse on susceptibility to severe pneumococcal pneumonia. Pneumonia is a major cause of morbidity and mortality in alcoholics, and the pneumococcus is the most ..
  11. STRESS AND MENTAL HEALTH IN OLDER ADULTS
    Janice Kiecolt Glaser; Fiscal Year: 2001
    ..By assessing immune responses to hepatitis A and pneumococcal pneumonia vaccines (as well as continued studies on influenza vaccine), the study will provide further data on ..
  12. Gender and Host Defense Against Pneumonia
    Lester Kobzik; Fiscal Year: 2009
    ..Pilot Data: Using a mouse model of the most common form of pneumonia, pneumococcal pneumonia, we observe greater resistance to infection in females or estrogen-treated males, demonstrated by better ..
  13. Microarray Determinants in Community-Acquired Pneumonia
    Kelly Wood; Fiscal Year: 2004
    ..substudy involves the recruitment of a prospective inception cohort (n=50) of elderly white males with pneumococcal pneumonia. The value that provocation testing (with pneumococcal vaccine) has in providing additional information ..
  14. Risk factors for drug resistant pneumococcal bacteremia
    Joshua Metlay; Fiscal Year: 2009
    ..study to develop a prediction rule for penicillin drug resistance among patients with bacteremic pneumococcal pneumonia. The proposed study will maintain our enrollment over an additional three years in order to complete six-..
  15. Inhaled Particles and Host Defense in the Primed Lung
    Lester Kobzik; Fiscal Year: 2007
    ..Hypothesis: The pathogenesis of the pneumococcal pneumonia (the most common variety and the disease we will study) suggests three possible mechanisms for particle ..
  16. MECHANISMS OF SICKLE CELL INDUCED LUNG INJURY
    Johnson Haynes; Fiscal Year: 1993
    ..Subsequent studies will assess the role of pneumococcal pneumonia in triggering acute lung injury in sickle cell disease...
  17. Influenza-pneumococcal synergism: role of neuraminidase
    Jonathan McCullers; Fiscal Year: 2004
    ....
  18. Synergism Between Influenza Virus and Pneumococcus
    Jonathan McCullers; Fiscal Year: 2009
    ....
  19. 2nd Orthomyxoviruses Research Conference
    Jonathan McCullers; Fiscal Year: 2003
    ..The purpose of this proposal is to provide funds that will allow promising young investigators to interact with their peers and develop a commitment to this area of research. ..
  20. Lethal synergism between influenza and pneumococcus
    Jonathan McCullers; Fiscal Year: 2003
    ..determine the role of receptor alterations engendered by influenza virus infection in the pathogenesis of pneumococcal pneumonia. A newly developed murine model of dual infection will be used to examine the relationships of timing and ..
  21. 3rd Orthomyxoviruses Research Conference
    Jonathan McCullers; Fiscal Year: 2005
    ..The purpose of this proposal is to provide funds that will allow promising young investigators to interact with their peers and develop a commitment to this area of research. ..
  22. Regulation of Pulmonary Host Defense by Leptin
    Peter Mancuso; Fiscal Year: 2010
    ..Individuals who are most susceptible to pneumococcal pneumonia include those who are energy malnourished as a secondary consequence of chronic diseases such as cancer, ..
  23. Defining Moxifloxacin as a First-line TB Drug
    Eric Nuermberger; Fiscal Year: 2008
    ..Relevance: Results of these studies will help to define optimal treatment regimens for TB that can be used to design new clinical trials or, in some cases, directly applied to clinical practice. ..
  24. A randomized trial of influenza vaccination of Hutterite children
    Mark Loeb; Fiscal Year: 2006
    ..We believe that the trial we propose will lead to important data that can inform policy on influenza immunization strategy. [unreadable] [unreadable] [unreadable]..
  25. Asthma and Invasive Pneumococcal Disease
    Young Juhn; Fiscal Year: 2006
    ..abstract_text> ..
  26. MOLECULAR AND CELLULAR BACTERIAL PATHOGENESIS
    David Briles; Fiscal Year: 2008
    ..The MCBP advisory committee will advise the trainees in their research and training programs and in their search for a job or postdoctoral position at the completion of their MCBP training. [unreadable] [unreadable]..
  27. The impact of the pneumococcal conjugate vaccine on pneumonia hospitalizations
    CARLOS GRIJALVA; Fiscal Year: 2008
    ..We propose the use of NIS and SID for the evaluation of the pneumococcal conjugate vaccination program, using an innovative approach. [unreadable] [unreadable] [unreadable] [unreadable]..
  28. Individual Housing Data and Socioeconomic Status
    Young Juhn; Fiscal Year: 2007
    ..Telephone interviews will be completed with 1,400 parents of children 1-18 years to obtain additional data. [unreadable] [unreadable]..
  29. MECHANISMS OF CELL INJURY IN BURN COMPLICATED BY SEPSIS
    Deborah Carlson; Fiscal Year: 2006
    ..The proposed work focuses on five specific aims to increase our understanding of the cellular events involved in burn and sepsis-related myocardial injury. ..
  30. QUINOLONE RESISTANCE MECHANISMS IN STAPHYLOCOCCUS AUREUS
    David Hooper; Fiscal Year: 2007
    ..abstract_text> ..
  31. NEUTROPHIL RECRUITMENT IN LPS-INDUCED AIRWAY DISEASE
    Jessica Moreland; Fiscal Year: 2004
    ....
  32. Recurrent otitis media and COPD: immunity and vaccines
    Timothy Murphy; Fiscal Year: 2004
    ..The proposed studies will advance the field of vaccine development to prevent otitis media and respiratory tract infections in COPD. ..
  33. IMMUNOGENETIC MECHANISMS OF VACCINE RESPONSE
    Gregory A Poland; Fiscal Year: 2010
    ..The knowledge gained from these studies will enable us to design new strategies and new vaccines to protect human health against viral diseases. ..
  34. The FastFasL system in lung injury
    Gustavo Matute Bello; Fiscal Year: 2006
    ..The proposed studies will allow for the acquisition of new techniques and further scientific development of the trainee into an independent investigator. ..
  35. "The alveolar epithelium in lung injury and repair"
    Gustavo Matute Bello; Fiscal Year: 2010
    ..In addition, we will investigate the potential treatments that will facilitate the repair of injured lungs. ..
  36. PULMONARY HUMORAL IMMUNE RESPONSES IN HIV INFECTION
    HOMER TWIGG; Fiscal Year: 2002
    ....
  37. The Efficacy of Reiki in the Treatment of Fibromyalgia & CFS
    Dedra Buchwald; Fiscal Year: 2003
    ..This pilot study could potentially impact the clinical care of the estimated 6 million Americans with FM, and shape the design of future larger, randomized, placebo-controlled trials of Reiki and other energy therapies. ..
  38. PROGRESSIVE IMPAIRMENT OF LUNG IMMUNITY IN HIV INFECTION
    HOMER TWIGG; Fiscal Year: 2002
    ....
  39. DETERMINING/UNDERSTANDING BARRIERS TO ADULT IMMUNIZATION
    Richard Zimmerman; Fiscal Year: 2001
    ..This project will furnish relevant, up-to-date to enhance policy planning, practice management and medical education. ..
  40. Pneumococcal immunization through a novel mechanism
    Richard Malley; Fiscal Year: 2010
    ..abstract_text> ..
  41. ALCOHOL, HIV, AND THE BRAIN
    Adolf Pfefferbaum; Fiscal Year: 2004
    ..Specific Aim 3: To establish cross-sectional and longitudinal within-subject relationships among nueroimaging, neuropsychological, and clinical measures. ..
  42. Pneumolysin, Innate and Acquired Immunity to Pneumococci
    Richard Malley; Fiscal Year: 2005
    ..The establishment of a link between the innate and the acquired arm of the immune response to pneumococcus may provide a better understanding of the mechanisms by which immunity to pneumococcus is acquired. ..
  43. Role of CIC-3 channels in regulation of cell volume and shape in neutrophils
    Jessica Moreland; Fiscal Year: 2007
    ..The studies proposed will advance our fundamental knowledge of the function of neutrophils in the maintenance of normal immune system function. [unreadable] [unreadable] [unreadable]..
  44. Healthy Homes II: Environmental/Clinical Asthma Control
    James Krieger; Fiscal Year: 2005
    ....
  45. HIV-Related Proteinuria and Endothelial Dysfunction
    Samir Gupta; Fiscal Year: 2007
    ..Dub6) in the fields of HIV metabolic and renal complications, renal vascular and glomerular pathology, and clinical trials design and implementation. ..
  46. ALCOHOL, HIV, AND THE BRAIN
    Adolf Pfefferbaum; Fiscal Year: 2006
    ..Specific Aim 3: To establish cross-sectional and longitudinal within-subject relationships among nueroimaging, neuropsychological, and clinical measures. ..
  47. Stress, the Immune System and Basal Cell Carcinoma
    Ronald Glaser; Fiscal Year: 2007
    ..2) We will determine if the relationships between depressive symptoms and severe life stressors and tumor immunoreactivity are more pronounced among older adults. ..
  48. Hormonal Opioids in Ischemic Preconditioning
    Eric Dickson; Fiscal Year: 2005
    ..Dickson with the facilities, equipment and expertise necessary to achieve the goals set forth in this proposal...
  49. Opioid abuse and host defense against streptococcus pneumoniae lung infection
    Jinghua Wang; Fiscal Year: 2008
    ..Ultimately, the studies will afford better development and design options when treating substance-abusing associated pneumoniae. [unreadable] [unreadable] [unreadable]..
  50. Healthy Homes & Community for High Point Families
    James Krieger; Fiscal Year: 2006
    ..Throughout these activities, the project will support the capacity of residents to assess, understand and address environmental issues affecting High Point in order to become empowered to act on them. ..
  51. Genital Ulcer Disease and HIV Transmission
    Jeanne Sheffield; Fiscal Year: 2005
    ..The pursuit of these aims will further elucidate the cellular and molecular bases of the interrelationship between GUD and HIV-1 transmission, particularly in women. ..
  52. DEVELOPMENT OF A VACCINE FOR MORAXELLA CATARRHALIS
    Timothy Murphy; Fiscal Year: 2009
    ..catarrhalis surface, the identification of surface antigens expressed specifically during human infection and critical information about the human immune response to surface antigens of M. catarrhalis. ..