gonorrhea

Summary

Summary: Acute infectious disease characterized by primary invasion of the urogenital tract. The etiologic agent, NEISSERIA GONORRHOEAE, was isolated by Neisser in 1879.

Top Publications

  1. ncbi What management is there for gonorrhea in the postquinolone era?
    John W Tapsall
    Sex Transm Dis 33:8-10. 2006
  2. pmc Is Neisseria gonorrhoeae initiating a future era of untreatable gonorrhea?: detailed characterization of the first strain with high-level resistance to ceftriaxone
    Makoto Ohnishi
    National Institute of Infectious Diseases, Tokyo, Japan
    Antimicrob Agents Chemother 55:3538-45. 2011
  3. ncbi Neisserial binding to CEACAM1 arrests the activation and proliferation of CD4+ T lymphocytes
    Ian C Boulton
    Department of Medical Genetics and Microbiology, University of Toronto, Medical Sciences Building Rm 4381, 1 Kings College Circle, Toronto, Ontario M5S1A8, Canada
    Nat Immunol 3:229-36. 2002
  4. ncbi Rapid sequence-based identification of gonococcal transmission clusters in a large metropolitan area
    Iona M C Martin
    Department of Infectious Diseases and Microbiology, Imperial College London, St Mary s Campus, London, United
    J Infect Dis 189:1497-505. 2004
  5. ncbi Prevalence of chlamydial and gonococcal infections among young adults in the United States
    William C Miller
    Department of Medicine, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill 27599 7435, USA
    JAMA 291:2229-36. 2004
  6. pmc Performance of the Abbott RealTime CT/NG for detection of Chlamydia trachomatis and Neisseria gonorrhoeae
    C A Gaydos
    Johns Hopkins University, 855 North Wolfe St, 530 Rangos Building, Baltimore, MD 21205, USA
    J Clin Microbiol 48:3236-43. 2010
  7. ncbi UK national guideline for the management of gonorrhoea in adults, 2011
    C Bignell
    Nottingham University Hospitals NHS Trust, Nottingham, UK
    Int J STD AIDS 22:541-7. 2011
  8. pmc High-level cefixime- and ceftriaxone-resistant Neisseria gonorrhoeae in France: novel penA mosaic allele in a successful international clone causes treatment failure
    Magnus Unemo
    WHO Collaborating Centre for Gonorrhoea and Other STIs, Department of Laboratory Medicine, Microbiology, Orebro University Hospital, Orebro, Sweden
    Antimicrob Agents Chemother 56:1273-80. 2012
  9. ncbi Women find it easy and prefer to collect their own vaginal swabs to diagnose Chlamydia trachomatis or Neisseria gonorrhoeae infections
    Max A Chernesky
    St Joseph s Healthcare, Hamilton, Ontario, Canada
    Sex Transm Dis 32:729-33. 2005
  10. pmc Emergence of quinolone resistance and cephalosporin MIC creep in Neisseria gonorrhoeae isolates from a cohort of young men in Kisumu, Kenya, 2002 to 2009
    Supriya D Mehta
    Division of Epidemiology and Biostatistics, University of Illinois at Chicago, Chicago, IL 60622, USA
    Antimicrob Agents Chemother 55:3882-8. 2011

Detail Information

Publications350 found, 100 shown here

  1. ncbi What management is there for gonorrhea in the postquinolone era?
    John W Tapsall
    Sex Transm Dis 33:8-10. 2006
  2. pmc Is Neisseria gonorrhoeae initiating a future era of untreatable gonorrhea?: detailed characterization of the first strain with high-level resistance to ceftriaxone
    Makoto Ohnishi
    National Institute of Infectious Diseases, Tokyo, Japan
    Antimicrob Agents Chemother 55:3538-45. 2011
    ..gonorrhoeae remains unknown, N. gonorrhoeae may soon become a true superbug, causing untreatable gonorrhea. A reduction in the global gonorrhea burden by enhanced disease control activities, combined with wider ..
  3. ncbi Neisserial binding to CEACAM1 arrests the activation and proliferation of CD4+ T lymphocytes
    Ian C Boulton
    Department of Medical Genetics and Microbiology, University of Toronto, Medical Sciences Building Rm 4381, 1 Kings College Circle, Toronto, Ontario M5S1A8, Canada
    Nat Immunol 3:229-36. 2002
    ..In addition, gonorrhea typically correlates with a transient reduction in T lymphocyte counts in blood, and these populations recover ..
  4. ncbi Rapid sequence-based identification of gonococcal transmission clusters in a large metropolitan area
    Iona M C Martin
    Department of Infectious Diseases and Microbiology, Imperial College London, St Mary s Campus, London, United
    J Infect Dis 189:1497-505. 2004
    In large metropolitan areas, which typically have the highest rates of gonorrhea, the identification of chains of transmission by use of partner notification is problematic, and there is an increasing interest in applying molecular ..
  5. ncbi Prevalence of chlamydial and gonococcal infections among young adults in the United States
    William C Miller
    Department of Medicine, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill 27599 7435, USA
    JAMA 291:2229-36. 2004
    ..Although screening for Chlamydia trachomatis is widely recommended among young adult women, little information is available regarding the prevalence of chlamydial and gonococcal infections in the general young adult population...
  6. pmc Performance of the Abbott RealTime CT/NG for detection of Chlamydia trachomatis and Neisseria gonorrhoeae
    C A Gaydos
    Johns Hopkins University, 855 North Wolfe St, 530 Rangos Building, Baltimore, MD 21205, USA
    J Clin Microbiol 48:3236-43. 2010
    ..trachomatis and N. gonorrhoeae dual detection with high sensitivity and specificity. The automated assay provides a useful alternative nucleic acid amplification assay for clinical laboratories and clinicians...
  7. ncbi UK national guideline for the management of gonorrhoea in adults, 2011
    C Bignell
    Nottingham University Hospitals NHS Trust, Nottingham, UK
    Int J STD AIDS 22:541-7. 2011
    ..The aim is to slow the spread of resistant gonorrhoea now that fewer antibiotics remain effective. A patient information leaflet has been developed...
  8. pmc High-level cefixime- and ceftriaxone-resistant Neisseria gonorrhoeae in France: novel penA mosaic allele in a successful international clone causes treatment failure
    Magnus Unemo
    WHO Collaborating Centre for Gonorrhoea and Other STIs, Department of Laboratory Medicine, Microbiology, Orebro University Hospital, Orebro, Sweden
    Antimicrob Agents Chemother 56:1273-80. 2012
    ..cephalosporins (ESCs) ceftriaxone and cefixime, which are the last remaining options for first-line gonorrhea treatment, was isolated in Japan...
  9. ncbi Women find it easy and prefer to collect their own vaginal swabs to diagnose Chlamydia trachomatis or Neisseria gonorrhoeae infections
    Max A Chernesky
    St Joseph s Healthcare, Hamilton, Ontario, Canada
    Sex Transm Dis 32:729-33. 2005
    ..We surveyed women's opinions on ease and preferences as to sampling after collecting their own vaginal swab and urine and a physician collection of vaginal swab and cervical swab...
  10. pmc Emergence of quinolone resistance and cephalosporin MIC creep in Neisseria gonorrhoeae isolates from a cohort of young men in Kisumu, Kenya, 2002 to 2009
    Supriya D Mehta
    Division of Epidemiology and Biostatistics, University of Illinois at Chicago, Chicago, IL 60622, USA
    Antimicrob Agents Chemother 55:3882-8. 2011
    ..High levels of plasmid-mediated resistance and increasing MICs for cephalosporins suggest that selective pressure from antibiotic use is a strong driver of resistance emergence...
  11. pmc Relationships of stigma and shame to gonorrhea and HIV screening
    J Dennis Fortenberry
    Section of Adolescent Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Am J Public Health 92:378-81. 2002
    The purpose of this study was to assess the relationships between stigma and shame associated with seeking treatment for sexually transmitted diseases (STDs) and undergoing testing for gonorrhea and HIV.
  12. pmc Emergence and spread of Neisseria gonorrhoeae clinical isolates harboring mosaic-like structure of penicillin-binding protein 2 in Central Japan
    Masayasu Ito
    Department of Urology, Gifu University School of Medicine, 1 1 Yanagido, Gifu City 501 1194, Japan
    Antimicrob Agents Chemother 49:137-43. 2005
    ..The emergence of such strains may be the result of the in vivo generation of clones in which interspecies recombination occurred between the penA genes of N. gonorrhoeae and commensal Neisseria species...
  13. ncbi Mind the gap: the role of time between sex with two consecutive partners on the transmission dynamics of gonorrhea
    Mark I Chen
    Centre for Infections, Health Protection Agency, London, UK
    Sex Transm Dis 35:435-44. 2008
    ..We use a mathematical model with multiple partnership durations and gap lengths to identify the types of relationship cycles that sustain gonorrhea transmission in the United Kingdom.
  14. pmc Are neighborhood sociocultural factors influencing the spatial pattern of gonorrhea in North Carolina?
    Ashleigh B Sullivan
    Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada
    Ann Epidemiol 21:245-52. 2011
    To determine if the spatial pattern of gonorrhea observed for North Carolina was influenced by neighborhood-level sociocultural determinants of health, including race/ethnicity.
  15. pmc Detection of Chlamydia trachomatis and Neisseria gonorrhoeae by enzyme immunoassay, culture, and three nucleic acid amplification tests
    E Van Dyck
    STD HIV Research and Intervention Unit, Department of Microbiology, Institute of Tropical Medicine, Nationalestraat 155, B 2000 Antwerp, Belgium
    J Clin Microbiol 39:1751-6. 2001
    ..trachomatis EIA. The accuracies of the different NAATs were quite similar. SDA was the only amplification assay with 100% specificity for detection of both N. gonorrhoeae and C. trachomatis in endocervical specimens...
  16. ncbi The efficacy of clinic-based interventions aimed at increasing screening for bacterial sexually transmitted infections among men who have sex with men: a systematic review
    Huachun Zou
    Sexual Health Unit, School of Population Health, University of Melbourne, Melbourne, Vic, Australia
    Sex Transm Dis 39:382-7. 2012
    ..We undertook a systematic review to identify clinic-based strategies for increasing screening and detection of bacterial STIs among MSM...
  17. ncbi Circulating levels of interleukin-17A and interleukin-23 are increased in patients with gonococcal infection
    Maria Cristina Gagliardi
    Dipartimento Malattie Infettive Parassitarie e Immunomediate, Istituto Superiore di Sanita, Rome, Italy
    FEMS Immunol Med Microbiol 61:129-32. 2011
    ..This is the first report showing a significant increase of IL-17A and IL-23 serum levels in patients with gonorrhoea, suggesting new players in the immune response to N. gonorrhoeae...
  18. pmc Spread of a chromosomal cefixime-resistant penA gene among different Neisseria gonorrhoeae lineages
    Makoto Ohnishi
    Department of Bacteriology, National Institute of Infectious Diseases, 1 23 1, Toyama, Shinjuku, Tokyo 162 8640, Japan
    Antimicrob Agents Chemother 54:1060-7. 2010
    ..Our results provide evidence that the capacity for natural transformation in N. gonorrhoeae plays a role in the spread of chromosomal antibiotic resistance genes and the generation of diversity in such genes...
  19. ncbi Emergence, spread and characteristics of Neisseria gonorrhoeae isolates with in vitro decreased susceptibility and resistance to extended-spectrum cephalosporins in Sweden
    Daniel Golparian
    National Reference Laboratory for Pathogenic Neisseria, Department of Laboratory Medicine, Clinical Microbiology, Orebro University Hospital, SE 701 85 Orebro, Sweden
    Sex Transm Infect 86:454-60. 2010
    ....
  20. ncbi Treatment of uncomplicated gonococcal urethritis by double-dosing of 200 mg cefixime at a 6-h interval
    Takashi Deguchi
    Department of Urology, Gifu University School of Medicine, 40 Tsukasa Machi, Gifu 500 8705, Japan
    J Infect Chemother 9:35-9. 2003
    ..This regimen would not be effective against infection by strains exhibiting cefixime MIC(90)s of > or =0.125 microg/ml. For such strains, a different regimen with a higher dose of cefixime would be required...
  21. ncbi The effect of genital tract infections on HIV-1 shedding in the genital tract: a systematic review and meta-analysis
    Leigh F Johnson
    Centre for Actuarial Research, University of Cape Town, South Africa
    Sex Transm Dis 35:946-59. 2008
    ..These infections are likely to be particularly important in promoting the sexual transmission and mother-to-child intrapartum transmission of HIV-1, and should therefore be the focus of HIV prevention strategies...
  22. pmc "Broken windows" and the risk of gonorrhea
    D Cohen
    Louisiana State University Medical Center, New Orleans 70112, USA
    Am J Public Health 90:230-6. 2000
    We examined the relationships between neighborhood conditions and gonorrhea.
  23. ncbi Gonorrhea and chlamydia in the United States among persons 14 to 39 years of age, 1999 to 2002
    S Deblina Datta
    Division of STD Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Ann Intern Med 147:89-96. 2007
    Nationally representative surveys of chlamydia and gonorrhea are an important measure of disease burden and progress of screening programs.
  24. ncbi Effect of expedited treatment of sex partners on recurrent or persistent gonorrhea or chlamydial infection
    Matthew R Golden
    Division of Infectious Diseases and the Center for AIDS and Sexually Transmitted Diseases, University of Washington, Seattle, USA
    N Engl J Med 352:676-85. 2005
    Many sex partners of persons with gonorrhea or chlamydial infections are not treated, which leads to frequent reinfections and further transmission.
  25. pmc Mouse strain-dependent differences in susceptibility to Neisseria gonorrhoeae infection and induction of innate immune responses
    Mathanraj Packiam
    Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814 4799, USA
    Infect Immun 78:433-40. 2010
    Acute gonorrhea in women is characterized by a mucopurulent exudate that contains polymorphonuclear leukocytes (PMNs) with intracellular gonococci. Asymptomatic infections are also common...
  26. ncbi Prevalence of rectal, urethral, and pharyngeal chlamydia and gonorrhea detected in 2 clinical settings among men who have sex with men: San Francisco, California, 2003
    Charlotte K Kent
    Department of Public Health, San Francisco, California, USA
    Clin Infect Dis 41:67-74. 2005
    ..for Disease Control and Prevention developed screening and diagnostic testing guidelines for chlamydia and gonorrhea at urethral, rectal, and pharyngeal sites for men who have sex with men (MSM)...
  27. pmc Incidence and risk factors for urethral and anal gonorrhoea and chlamydia in a cohort of HIV-negative homosexual men: the Health in Men Study
    F Jin
    National Centre in HIV Epidemiology and Clinical Research, University of New South Wales, Sydney, New South Wales, Australia
    Sex Transm Infect 83:113-9. 2007
    ..Early detection and treatment of bacterial sexually transmitted infections has been advocated as an HIV prevention strategy...
  28. ncbi What proportion of episodes of gonorrhoea and chlamydia becomes symptomatic?
    Eline L Korenromp
    Department of Public Health, Erasmus University Rotterdam, The Netherlands
    Int J STD AIDS 13:91-101. 2002
    ..In populations with low treatment rates like Uganda, these probabilities can be very low. Here, health education should have priority in STD management programmes...
  29. pmc Social capital, poverty, and income inequality as predictors of gonorrhoea, syphilis, chlamydia and AIDS case rates in the United States
    D R Holtgrave
    Emory University, Rollins School of Public Health, Center for AIDS Research, 1518 Clifton Road NE, Room 540, Atlanta, GA 30322, USA
    Sex Transm Infect 79:62-4. 2003
    ..Therefore, any exploration of the correlation between social capital and infectious diseases should also include examination of the association with poverty and income inequality...
  30. pmc Alcohol outlets, gonorrhea, and the Los Angeles civil unrest: a longitudinal analysis
    Deborah A Cohen
    RAND Corp, 1776 Main Street, Santa Monica, CA 90407, USA
    Soc Sci Med 62:3062-71. 2006
    This study tests the effect of neighborhood changes on gonorrhea rates...
  31. pmc A gonococcal efflux pump system enhances bacterial survival in a female mouse model of genital tract infection
    Ann E Jerse
    Department of Microbiology and Immunology, F Edward Hebert School of Medicine, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, USA
    Infect Immun 71:5576-82. 2003
    ..However, hormonally regulated factors rather than progesterone itself may be responsible for the more rapid clearance of mtr-deficient gonococci from intact mice...
  32. pmc Local and humoral immune responses against primary and repeat Neisseria gonorrhoeae genital tract infections of 17beta-estradiol-treated mice
    Wenxia Song
    Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland 20742, USA
    Vaccine 26:5741-51. 2008
    ..We conclude that similar to human infection, experimental murine infection induces local inflammation but not an acquired immune response or immunological memory...
  33. ncbi Asymptomatic sexually transmitted diseases: the case for screening
    Thomas A Farley
    Louisiana Office of Public Health, and the Department of Community Health Sciences, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA
    Prev Med 36:502-9. 2003
    ..The United States has the highest prevalence of sexually transmitted diseases in the developed world. Control strategies should address the most frequent reasons why curable sexually transmitted diseases are not treated...
  34. pmc Amino acid substitutions in mosaic penicillin-binding protein 2 associated with reduced susceptibility to cefixime in clinical isolates of Neisseria gonorrhoeae
    Sho Takahata
    Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd, 760 Morooka cho, Kohoku Ku, Yokohama 222 8567, Japan
    Antimicrob Agents Chemother 50:3638-45. 2006
    ..Therefore, three mutations (G545S, I312M, and V316T) in mosaic PBP2 were identified as the amino acid substitutions responsible for reduced susceptibility to cefixime in N. gonorrhoeae...
  35. ncbi Screening women in jails for chlamydial and gonococcal infection using urine tests: feasibility, acceptability, prevalence, and treatment rates
    Kristen J Mertz
    Division of STD Prevention, National Center for HIV, STD, and TB Prevention, Atlanta, Georgia 30333, USA
    Sex Transm Dis 29:271-6. 2002
    ..New urine tests have made it easier to screen for these infections in nonclinical settings...
  36. pmc Mutation in 23S rRNA associated with macrolide resistance in Neisseria gonorrhoeae
    Lai King Ng
    National Laboratory for Sexually Transmitted Diseases, National Microbiology Laboratory, Population and Public Health Branch, Health Canada, Winnipeg, Manitoba, Canada
    Antimicrob Agents Chemother 46:3020-5. 2002
    ..coli, Streptococcus pneumoniae, and Helicobacter pylori, this is the first observation of these mutations associated with macrolide resistance in N. gonorrhoeae...
  37. ncbi False-positive gonorrhea test results with a nucleic acid amplification test: the impact of low prevalence on positive predictive value
    Alan R Katz
    Department of Public Health Sciences and Epidemiology, John A Burns School of Medicine, University of Hawaii, Honolulu, HI 96822, USA
    Clin Infect Dis 38:814-9. 2004
    Five false-positive gonorrhea test results from a private laboratory using a nucleic acid amplification test led to an investigation by the Hawaii State Department of Health...
  38. ncbi Surveillance of antibiotic resistance in Neisseria gonorrhoeae in the WHO Western Pacific and South East Asian Regions, 2010
    Monica M Lahra
    WHO Collaborating Centre for STD, Department of Microbiology, SEALS The Prince of Wales Hospital, Randwick, New South Wales
    Commun Dis Intell Q Rep 36:95-100. 2012
    ....
  39. ncbi Emerging antimicrobial resistance in Neisseria gonorrhoeae: urgent need to strengthen prevention strategies
    Kimberly A Workowski
    National Center for HIV AIDS, Viral Hepatitis, STD and TB Prevention, Centers for Disease Control and Prevention, and Emory University, Atlanta, Georgia, USA
    Ann Intern Med 148:606-13. 2008
    Prevention and control of gonorrhea is an important public health concern due to the high burden of disease, the recent increase in reported infection rates, and the reproductive and economic consequences of infection...
  40. ncbi Neisseria gonorrhoeae antimicrobial susceptibility in Lilongwe, Malawi, 2007
    Lillian B Brown
    Division of Infectious Diseases, University of North Carolina Chapel Hill, Chapel Hill, NC 27599, USA
    Sex Transm Dis 37:169-72. 2010
    ..We sought to establish current laboratory-based Neisseria gonorrhoeae antibiotic susceptibility patterns for Malawi and describe the pattern of susceptibility since syndromic management began...
  41. ncbi Nucleic acid amplification tests for gonorrhea and chlamydia: practice and applications
    Charlotte A Gaydos
    Division of Infectious Diseases, Medicine, Johns Hopkins University School of Medicine, 1159 Ross Research Building, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Infect Dis Clin North Am 19:367-86, ix. 2005
    ..Self-collected genital specimens, such as urine or even vaginal swabs, can now be accurately used to diagnose gonorrhea or chlamydia infections...
  42. pmc Emergence of multidrug-resistant, extensively drug-resistant and untreatable gonorrhea
    Magnus Unemo
    WHO Collaborating Centre for Gonorrhoea and Other STIs, National Reference Laboratory for Pathogenic Neisseria, Orebro University Hospital, SE 701 85 Orebro, Sweden
    Future Microbiol 7:1401-22. 2012
    ..the extended-spectrum cephalosporin, ceftriaxone, the last remaining option for first-line empiric treatment of gonorrhea. An era of untreatable gonorrhea may be approaching, which represents an exceedingly serious public health ..
  43. ncbi Increased risk of chlamydial and gonococcal infection in adolescent sex workers in Madagascar
    Audrey E Pettifor
    Department of Epidemiology, University of North Carolina, Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Sex Transm Dis 34:475-8. 2007
    ..To examine and compare young sex workers' risk of acquisition of sexually transmitted infections (STIs) with the risk among their older counterparts...
  44. pmc Correlates of injection drug use among female sex workers in two Mexico-U.S. border cities
    Steffanie A Strathdee
    School of Medicine, University of California San Diego, La Jolla, CA, USA
    Drug Alcohol Depend 92:132-40. 2008
    ..To characterize the overlap between injection drug use and sex work by women in Tijuana and Cd. Juarez, situated on the Mexico-U.S. border...
  45. ncbi Epidemiology of sexually transmitted infections on the Anangu Pitjantjatjara Yankunytjatjara Lands: results of a comprehensive control program
    Rae Lin Huang
    Nganampa Health Council, Alice Springs, NT, Australia
    Med J Aust 189:442-5. 2008
    ..To assess the impact of a long-term comprehensive control program for sexually transmitted infections (STIs) in remote Aboriginal communities in Central Australia, and to investigate a recent rise in gonorrhoea prevalence...
  46. pmc Phosphatidylinositol 3'-kinase activity is critical for initiating the oxidative burst and bacterial destruction during CEACAM3-mediated phagocytosis
    Alexander Buntru
    Lehrstuhl für Zellbiologie, Universitat Konstanz, 78457 Konstanz, Germany
    J Biol Chem 286:9555-66. 2011
    ..Together, our results highlight the ability of CEACAM3 to coordinate signaling events that not only mediate bacterial uptake, but also trigger the killing of internalized pathogens...
  47. ncbi Prevalence of gonococcal and chlamydial infections and sexual risk behavior among youth in Addis Ababa, Ethiopia
    Negussie Taffa
    Department of International Health, Institute of General Practice and Community Medicine, University of Oslo, Oslo, Norway
    Sex Transm Dis 29:828-33. 2002
    ..No community-based study on the magnitude of sexually transmitted diseases (STDs) has ever been conducted among young people in Ethiopia...
  48. pmc Home versus clinic-based specimen collection for Chlamydia trachomatis and Neisseria gonorrhoeae
    Anna S Graseck
    Washington University in St Louis School of Medicine, Division of Clinical Research, Department of Obstetrics and Gynecology, Campus Box 8219, 4533 Clayton Avenue, St Louis, MO 63110, USA
    Expert Rev Anti Infect Ther 9:183-94. 2011
    ..This article describes and evaluates the effectiveness and limitations of various home screening strategies used for the detection of STIs...
  49. ncbi Trends in antimicrobial resistance of Neisseria gonorrhoeae isolated from Korean patients from 2000 to 2006
    Hyukmin Lee
    Department of Laboratory Medicine, Kwandong University College of Medicine, Goyang, Korea
    Sex Transm Dis 38:1082-6. 2011
    ..emergence and spread of antimicrobial-resistant Neisseria gonorrhoeae has compromised treatment and control of gonorrhea. We determined recent trends in antimicrobial susceptibility of the isolates, analyzed recent use of ..
  50. pmc Evaluation of self-collected vaginal swab, first void urine, and endocervical swab specimens for the detection of Chlamydia trachomatis and Neisseria gonorrhoeae in adolescent females
    Junyong Fang
    Department of Pediatrics, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Pediatr Adolesc Gynecol 21:355-60. 2008
    To assess the concordance of self-obtained vaginal swabs (SVS), first void urine samples (FVU) and provider-collected endocervical swabs (PES) for the detection of Chlamydia trachomatis (CT) and Neisseria gonorrhea (NG) in adolescents.
  51. pmc Trends in chlamydia and gonorrhea positivity among heterosexual men and men who have sex with men attending a large urban sexual health service in Australia, 2002-2009
    Lenka A Vodstrcil
    Melbourne School of Population Health, The University of Melbourne, Vic, Australia
    BMC Infect Dis 11:158. 2011
    To determine whether chlamydia positivity among heterosexual men (MSW) and chlamydia and gonorrhea positivity among men who have sex with men (MSM), are changing.
  52. ncbi Antimicrobial resistance in sexually transmitted infections in the developed world: implications for rational treatment
    Catherine A Ison
    Sexually Transmitted Bacteria Reference Laboratory, Health Protection Agency, London, UK
    Curr Opin Infect Dis 25:73-8. 2012
    ..The scope of the problem and the implications for treatment that follow are discussed in this review...
  53. ncbi Characterization of profile of multidrug-resistant Neisseria gonorrhoeae using old and new definitions in India over a decade: 2000-2009
    Manju Bala
    Regional STD Teaching, Training and Research Centre, Vardhman Mahavir Medical College and Safdarjang Hospital, New Delhi, India
    Sex Transm Dis 38:1056-8. 2011
    ..The emergence of resistance to ceftriaxone and cefixime will lead to detection of MDR-NG and may be extensively drug-resistant NG, even according to the new definition...
  54. ncbi Epidemilogical analysis of Neisseria gonorrhoeae isolates by antimicrobial susceptibility testing, auxotyping and serotyping
    P Khaki
    Department of Microbiology, Mualana Azad Medical College, New Delhi 110 002, India
    Indian J Med Microbiol 25:225-9. 2007
    This study was carried out to analyze the epidemiology of gonorrhea based on antimicrobial susceptibility testing, auxotyping and serotyping in New Delhi, India.
  55. pmc The prevalence of chlamydia, gonorrhea, and trichomonas in sexual partnerships: implications for partner notification and treatment
    Ayesha Khan
    Division of Infectious Diseases, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Sex Transm Dis 32:260-4. 2005
    ..However, limited data exists regarding STIs within sexual partnerships (dyads)...
  56. ncbi Neighbourhood alcohol availability and gonorrhea rates: impact of social capital
    Katherine P Theall
    Louisiana State University, School of Public Health, New Orleans, LA 70112, USA
    Geospat Health 3:241-55. 2009
    ..We determined whether indicators of social capital are (i) associated with neighbourhood gonorrhea rates, and (ii) mediate the relation between alcohol outlet density and gonorrhea rate...
  57. pmc Difference in risk behaviors and STD prevalence between street-based and establishment-based FSWs in Guangdong Province, China
    Yan Li
    Center for Disease Control and Prevention of Guangdong Province, Guangzhou, China
    AIDS Behav 16:943-51. 2012
    ..The respondents were interviewed using a structured questionnaire, and tested for HIV, syphilis, gonorrhea, and Chlamydia...
  58. ncbi Bacterial vaginosis, gonorrhea, and chlamydial infection among women attending a sexually transmitted disease clinic: a longitudinal analysis of possible causal links
    Maria F Gallo
    Division of Reproductive Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, 4770 Buford Highway, Atlanta, GA 30341, USA
    Ann Epidemiol 22:213-20. 2012
    Interactions between bacterial vaginosis (BV) and inflammatory sexually transmitted infections, such as gonorrhea and chlamydial infection, are not well understood...
  59. pmc Use of an adaptation of a commercially available PCR assay aimed at diagnosis of chlamydia and gonorrhea to detect Trichomonas vaginalis in urogenital specimens
    Barbara Van Der Pol
    Division of Infectious Diseases, Indiana University Scool of Medicine, Indianapolis, IN 46202, USA
    J Clin Microbiol 44:366-73. 2006
    ..Using samples prepared for, and reagents from, the C. trachomatis-N. gonorrhoeae PCR assay allowed incorporation of T. vaginalis PCR diagnosis into routine clinical testing...
  60. pmc Duration of persistence of gonococcal DNA detected by ligase chain reaction in men and women following recommended therapy for uncomplicated gonorrhea
    Laura H Bachmann
    Department of Medicine, University of Alabama at Birmingham, 242 Zeigler Research Building, 703 19th Street South, Birmingham, AL 35294 0007, USA
    J Clin Microbiol 40:3596-601. 2002
    ..women between the ages of 16 and 50 years presenting to a sexually transmitted disease clinic with urogenital gonorrhea were enrolled...
  61. ncbi Clusters of circulating Neisseria gonorrhoeae strains and association with antimicrobial resistance in Shanghai
    Mingmin Liao
    Vaccine and Infectious Disease Organization, University of Saskatchewan, 120 Veterinary Road, Saskatoon, Saskatchewan, Canada S7N 5E3
    J Antimicrob Chemother 61:478-87. 2008
    ....
  62. pmc First neisseria gonorrhoeae genotyping analysis in france: identification of a strain cluster with reduced susceptibility to Ceftriaxone
    Laura Monfort
    Institut Alfred Fournier, 25 boulevard Saint Jacques, 75014 Paris, France
    J Clin Microbiol 47:3540-5. 2009
    ..Of note, no predominant ST was identified among rectal isolates from men who have sex with men...
  63. ncbi Rectal gonorrhea and chlamydia reinfection is associated with increased risk of HIV seroconversion
    Kyle T Bernstein
    Epidemiology, Research and Surveillance, STD Prevention and Control Services, San Francisco Department of Public Health, San Francisco, CA 94103, USA
    J Acquir Immune Defic Syndr 53:537-43. 2010
    ..HIV infection continues to disproportionately affect men who have sex with men (MSM). Identification of modifiable risk factors for HIV infection among MSM is critical for effective prevention...
  64. pmc Threat to cefixime treatment for gonorrhea
    Shigeaki Yokoi
    Emerg Infect Dis 13:1275-7. 2007
  65. ncbi Cephalosporin MIC creep among gonococci: time for a pharmacodynamic rethink?
    Stephanie A Chisholm
    Health Protection Agency Centre for Infections, 61 Colindale Avenue, London NW9 5EQ, UK
    J Antimicrob Chemother 65:2141-8. 2010
    ..Decreased cephalosporin susceptibility is now being reported. We examined cephalosporin MIC trends for Neisseria gonorrhoeae in the UK and undertook pharmacodynamic analyses to predict efficacy against strains with raised MICs...
  66. ncbi Patterns of chlamydia and gonorrhea infection in sexual networks in Manitoba, Canada
    J L Wylie
    Cadham Provincial Laboratory, Manitoba Health, Winnipeg, Canada
    Sex Transm Dis 28:14-24. 2001
    ..The use of sexual network analysis has the potential to further our understanding of sexually tranmitted disease (STD) epidemics and contribute to the development of more effective targeted control strategies...
  67. pmc Multicenter evaluation of the BDProbeTec ET System for detection of Chlamydia trachomatis and Neisseria gonorrhoeae in urine specimens, female endocervical swabs, and male urethral swabs
    B Van Der Pol
    Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Clin Microbiol 39:1008-16. 2001
    ....
  68. ncbi Lack of effectiveness of cellulose sulfate gel for the prevention of vaginal HIV transmission
    Lut Van Damme
    CONRAD, Arlington, VA, USA
    N Engl J Med 359:463-72. 2008
    ..Women make up more than 50% of adults living with human immunodeficiency virus (HIV) infection or the acquired immunodeficiency syndrome (AIDS) in sub-Saharan Africa. Thus, female-initiated HIV prevention methods are urgently needed...
  69. ncbi Nucleic acid amplification tests in the diagnosis of chlamydial and gonococcal infections of the oropharynx and rectum in men who have sex with men
    Julius Schachter
    Department of Laboratory Medicine, University of California, San Francisco, CA 94110, USA
    Sex Transm Dis 35:637-42. 2008
    ....
  70. pmc Chlamydia trachomatis and Neisseria gonorrhoeae infection and the sexual behaviour of men who have sex with men
    P D Benn
    Department of Genitourinary Medicine, Mortimer Market Centre, off Capper Street, London WC1B 6AU, UK
    Sex Transm Infect 83:106-12. 2007
    ..Rates of bacterial sexually transmitted infections (STIs) continue to rise among men who have sex with men (MSM) in the UK...
  71. ncbi Update on the management of gonorrhea in adults in the United States
    Lori M Newman
    Division of STD Prevention, National Center for HIV AIDS, Viral Hepatitis, STD and TB Prevention Proposed, Atlanta, GA 30333, USA
    Clin Infect Dis 44:S84-101. 2007
    b>Gonorrhea, the second most commonly reported notifiable disease, is an important cause of cervicitis, urethritis, and pelvic inflammatory disease. The selection of appropriate therapy for gonorrhea (i.e...
  72. ncbi Molecular epidemiology of recently emergent ciprofloxacin-resistant Neisseria gonorrhoeae in South Africa
    Prashini Moodley
    Department of Medical Microbiology, Nelson R Mandela School of Medicine, University of KwaZuluNatal, South Africa
    Sex Transm Dis 33:357-60. 2006
    ..In 2003, reports of clinical failure of gonorrhea following ciprofloxacin treatment prompted a clinic-based surveillance to detect the presence of resistant ..
  73. ncbi Systematic review: noninvasive testing for Chlamydia trachomatis and Neisseria gonorrhoeae
    Robert L Cook
    Division of General Internal Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Ann Intern Med 142:914-25. 2005
    ..Testing of urine samples is noninvasive and could overcome several barriers to screening for chlamydial and gonococcal infections, but most test samples are obtained directly from the cervix or urethra...
  74. ncbi Antimicrobial susceptibility of Neisseria gonorrhoeae strains isolated in 2004-2006 in Bangui, Central African Republic; Yaoundé, Cameroon; Antananarivo, Madagascar; and Ho Chi Minh Ville and Nha Trang, Vietnam
    Van Cao
    Institut Pasteur d Ho Chi Minh Ville, Vietnam
    Sex Transm Dis 35:941-5. 2008
    ....
  75. ncbi Antibiotic resistance in Neisseria gonorrhoeae is diminishing available treatment options for gonorrhea: some possible remedies
    John Tapsall
    World Health Organization Collaborating Centre for STD and HIV, Microbiology Department, The Prince of Wales Hospital, Sydney, Australia
    Expert Rev Anti Infect Ther 4:619-28. 2006
    b>Gonorrhea is essentially out of control in many settings and high disease rates are coupled with the spread of multiresistant gonococci...
  76. pmc Results of a randomised trial of male condom promotion among Madagascar sex workers
    P J Feldblum
    Family Health International, PO Box 13950, Research Triangle Park, NC 27709, USA
    Sex Transm Infect 81:166-73. 2005
    ..To test the effect of supplementing peer promotion of male condom use with clinic based counselling, measured in terms of STI prevalence and reported male condom use...
  77. ncbi Two cases of failed ceftriaxone treatment in pharyngeal gonorrhoea verified by molecular microbiological methods
    John Tapsall
    World Health Organization Collaborating Centre for STD, Prince of Wales Hospital, Sydney, Australia
    J Med Microbiol 58:683-7. 2009
    ..Different penA changes were detected in the N. gonorrhoeae isolated from the two cases. These were associated with raised ceftriaxone MICs of 0.03 and 0.016 mg l(-1), which may have contributed to the treatment failures in these cases...
  78. pmc A fast real-time polymerase chain reaction method for sensitive and specific detection of the Neisseria gonorrhoeae porA pseudogene
    Stig Ove Hjelmevoll
    Department of Microbiology and Infection Control, University Hospital of North Norway, 9038 Tromsø, Norway
    J Mol Diagn 8:574-81. 2006
    ..In conclusion, the N. gonorrhoeae porA pseudogene real-time PCR developed in the present study is highly sensitive, specific, robust, rapid and reproducible, making it suitable for diagnosis of N. gonorrhoeae infection...
  79. ncbi Screening for chlamydia and gonorrhoea in men who have sex with men in clinical and non-clinical settings
    Marian J Currie
    Academic Unit of Internal Medicine, Australian National University Medical School, Canberra Clinical School, The Canberra Hospital, Woden, ACT
    Sex Health 3:123-6. 2006
    ..Our aim was to determine the rate of positive chlamydia and gonorrhoea tests in this population in the Australian Capital Territory (ACT)...
  80. pmc The available pool of sex partners and risk for a current bacterial sexually transmitted infection
    Jacky M Jennings
    Johns Hopkins University School of Medicine, Department of Pediatrics, Baltimore, MD, USA
    Ann Epidemiol 20:532-8. 2010
    ..The objective of this study was to determine whether the prevalence of STIs among the available pool of sex partners in a neighborhood, measured indirectly, is an independent determinant of a current incident STI...
  81. ncbi Antimicrobial susceptibility of Neisseria gonorrhoeae in Greece: data for the years 1994-2004
    Maria Stathi
    The National Reference Center for Neisseria gonorrhoeae, Laboratory of Bacteriology, Hellenic Pasteur Institute, Athens, Greece
    J Antimicrob Chemother 57:775-9. 2006
    ..Surveillance data concerning antimicrobial susceptibilities of Neisseria gonorrhoeae isolated in Greece during the 11 year period 1994-2004 are presented...
  82. doi Cluster of multidrug-resistant Neisseria gonorrhoeae with reduced susceptibility to the newer cephalosporins in Northern Greece
    Eva Tzelepi
    J Antimicrob Chemother 62:637-9. 2008
  83. pmc Outbreak of cefozopran (penicillin, oral cephems, and aztreonam)-resistant Neisseria gonorrhoeae in Japan
    T Muratani
    Department of Urology, School of Medicine, University of Occupational and Environmental Health, 1 1 Iseigaoka, Yahatanishi ku, Kitakyushu, Japan
    Antimicrob Agents Chemother 45:3603-6. 2001
    ..Restriction fragment length polymorphism DNA typing revealed that the outbreak of cefozopran-resistant isolates in Kitakyushu, Japan, occurred as a result of clonal spread...
  84. pmc Reproducibility of positive test results in the BDProbeTec ET system for detection of Chlamydia trachomatis and Neisseria gonorrhoeae
    Elizabeth E Culler
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, USA
    J Clin Microbiol 41:3911-4. 2003
    ..7%. The data suggest that retesting of low-positive samples is warranted and could reduce the number of potentially false-positive test results...
  85. ncbi Identification of individuals with gonorrhoea within sexual networks: a population-based study
    Bhudipa Choudhury
    Department of Infectious Disease Epidemiology, Imperial College London, London, UK
    Lancet 368:139-46. 2006
    ..Our aim was to examine the application of high-throughput molecular approaches that can identify individuals in linked sexual networks...
  86. ncbi Gonorrhea, syphilis, clinical prostatitis, and the risk of prostate cancer
    Siobhan Sutcliffe
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Room E6138, 615 North Wolfe Street, Baltimore, MD 21205, USA
    Cancer Epidemiol Biomarkers Prev 15:2160-6. 2006
    Although previous case-control studies have observed positive associations among gonorrhea, syphilis, clinical prostatitis, and prostate cancer, many may have been susceptible to recall and interviewer biases due to their retrospective ..
  87. pmc Spatial analysis and mapping of sexually transmitted diseases to optimise intervention and prevention strategies
    D C G Law
    Epidemiology Department, CB 7435, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7435, USA
    Sex Transm Infect 80:294-9. 2004
    ....
  88. ncbi Vicious and virtuous circles in the dynamics of infectious disease and the provision of health care: gonorrhea in Britain as an example
    Peter J White
    Department of Infectious Disease Epidemiology, Imperial College Faculty of Medicine, London, United Kingdom
    J Infect Dis 192:824-36. 2005
    ..explore the relationship between capacity and demand for care, we developed and analyzed a mathematical model of gonorrhea transmission, incorporating patient flow through treatment services and heterogeneity in sexual risk behavior...
  89. pmc Molecular epidemiology of Neisseria gonorrhoeae: sequence analysis of the porB gene confirms presence of two circulating strains
    Magnus Unemo
    National Reference Laboratory for Pathogenic Neisseria, Department of Clinical Microbiology, Orebro University Hospital, SE 701 85 Orebro, Sweden
    J Clin Microbiol 40:3741-9. 2002
    ..gonorrhoeae strains, as well as for confirmation or discrimination of clusters of gonorrhea cases.
  90. ncbi Human immunodeficiency virus and other sexually transmitted infections among female sex workers in two major cities in Papua New Guinea
    Charles S Mgone
    Papua New Guinea Institute of Medical Research, Goroka, Papua New Guinea
    Sex Transm Dis 29:265-70. 2002
    ..Treatable sexually transmitted infections are very common in developing countries and quite often are inadequately treated or remain untreated despite the fact that they enhance the transmission of human immunodeficiency virus (HIV)...
  91. ncbi Analysis of trends in antimicrobial resistance in Neisseria gonorrhoeae isolated in Australia, 1997 2006
    J W Tapsall
    Department of Microbiology, The Prince of Wales Hospital, Randwick, New South Wales, Australia
    J Antimicrob Chemother 61:150-5. 2008
    ..To analyse trends in antimicrobial resistance (AMR) in Neisseria gonorrhoeae (GC) isolated in Australia between 1997 and 2006 and to identify factors influencing emergence and spread of AMR in GC...
  92. pmc Molecular epidemiology of Neisseria gonorrhoeae in Amsterdam, The Netherlands, shows distinct heterosexual and homosexual networks
    Marion Eliëtte Kolader
    STI Clinic, Cluster of Infectious Diseases, Health Service of Amsterdam, Amsterdam, The Netherlands
    J Clin Microbiol 44:2689-97. 2006
    Molecular typing, added to epidemiological data, can better identify transmission patterns of gonorrhea in Western countries, where the incidence has recently been rising...
  93. pmc Diversion of the immune response to Neisseria gonorrhoeae from Th17 to Th1/Th2 by treatment with anti-transforming growth factor β antibody generates immunological memory and protective immunity
    Yingru Liu
    Department of Microbiology and Immunology and Witebsky Center for Microbial Pathogenesis and Immunology, University at Buffalo, Buffalo, New York, USA
    MBio 2:e00095-11. 2011
    ..Blockade of TGF-β reverses this pattern of host immune responsiveness and facilitates the emergence of protective antigonococcal immunity...
  94. pmc Prevalence and risk factors of chlamydia and gonorrhea among rural Nepali women
    P Christian
    Department of International Health, The Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe Street, Room W2041, Baltimore, MD 21205, USA
    Sex Transm Infect 81:254-8. 2005
    ..We estimated the prevalence and risk factors of Neisseria gonorrhoeae and Chlamydia trachomatis in a female population in rural Nepal...
  95. pmc Antimicrobial resistance of Neisseria gonorrhoeae and high prevalence of ciprofloxacin-resistant isolates in Japan, 1993 to 1998
    M Tanaka
    Department of Urology, Faculty of Medicine, Kyushu University, Japan
    J Clin Microbiol 38:521-5. 2000
    ..Ciprofloxacin-resistant isolates contained three or four amino acid substitutions within the QRDR in the GyrA and ParC proteins...
  96. ncbi A sustainable behavioral intervention to increase condom use and reduce gonorrhea among sex workers in Singapore: 2-year follow-up
    M L Wong
    Department of Community, Occupational, and Family Medicine, National University of Singapore, Singapore
    Prev Med 27:891-900. 1998
    ..We developed and evaluated the sustainability of an intervention to increase condom use and reduce gonorrhea among brothel-based sex workers in Singapore...
  97. ncbi Ciprofloxacin resistance in Neisseria gonorrhoeae in England and Wales in 2002
    Kevin A Fenton
    Communicable Disease Surveillance Centre, Health Protection Agency, London, UK
    Lancet 361:1867-9. 2003
    ..These findings suggest that national and local treatment guidelines need to be reviewed urgently...
  98. ncbi High prevalence of ciprofloxacin-resistant Neisseria gonorrhoeae in Northern Taiwan
    Po Ren Hsueh
    Department of Laboratory Medicine, National Taiwan University Hospital, Taipei, Taiwan
    Clin Infect Dis 40:188-92. 2005
    ..1%) of 29 isolates obtained in 2003. Pulsed-field gel electrophoresis analysis indicated that several clones predominated among the ciprofloxacin-resistant isolates...
  99. ncbi Injectable use may increase women's odds of getting chlamydia or gonorrhea
    R MacLean
    Int Fam Plan Perspect 31:45-6. 2005
  100. pmc Pathogen recognition in the human female reproductive tract: expression of intracellular cytosolic sensors NOD1, NOD2, RIG-1, and MDA5 and response to HIV-1 and Neisseria gonorrhea
    Mimi Ghosh
    Department of Epidemiology and Biostatistics, The George Washington University, Washington, DC 20037, USA
    Am J Reprod Immunol 69:41-51. 2013
    ..Expression patterns and regulation of cytosolic pattern recognition receptors (PRR) NOD-1, NOD-2, RIG-1, and MDA5 have not been elucidated in the human female reproductive tract (FRT)...
  101. pmc Sexually transmitted infections and risk factors for gonorrhea and chlamydia in female sex workers in Soc Trang, Vietnam
    Thuong Vu Nguyen
    Pasteur Institute, Ho Chi Minh City, Vietnam
    Sex Transm Dis 35:935-40. 2008
    To determine the prevalence of selected STIs and correlates of chlamydia (CT) and gonorrhea (GC) infection among (FSWs) in Soc Trang province, Vietnam.

Research Grants74

  1. Gonococcal resistance to peroxynitrite
    Virginia L Clark; Fiscal Year: 2010
    DESCRIPTION: Neisseria gonorrhoeae is the causative agent of gonorrhea, one of the most prevalent infectious diseases in this country...
  2. Gonococcal Mechanisms to Evade Host Defenses
    WILLIAM MAURICE SHAFER; Fiscal Year: 2013
    ..Relevance to Veterans Health Unfortunately, despite a downward trend in the total number of yearly cases of gonorrhea in the United States since the mid-1980s, the incidence of this infection remains at a distressingly high level ..
  3. Development of an HIV Risk Reduction Intervention Protocol for Adolescent Africn-
    GWENDOLYN D CHILDS; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Alabama STI surveillance reports reveal rates of chlamydia, syphilis, and gonorrhea among African American (AA) girl increase more than 1000% between age groups 10 to 14 and 15 to 19, suggesting ..
  4. Research Training Prog in Reproductive Biol & Med for Latin American Scientists
    John E Nestler; Fiscal Year: 2010
    ..ovary syndrome and insulin resistance, preterm birth, pre-eclampsia, fetal membrane rupture, cell signaling, gonorrhea vaccine development, steroidogenesis, and promotion of healthy pregnancy...
  5. HIV Prevention Intervention for Young Transgender Women
    MATTHEW JAMES MIMIAGA; Fiscal Year: 2013
    ..All three arms will receive HIV and STI (Chlamydia and gonorrhea) testing and pre-posttest risk reduction counseling (i.e., SOC)...
  6. Rapid and Cost-Effective Diagnostic System for Sexually Transmitted Infections
    John E Mueller; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): According to the CDC, chlamydia and gonorrhea, caused by Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG), respectively, are the first and second most frequently reported STIs in the US and ..
  7. Sexual Health among Low-Income Female CSWs in China
    JENNIFER ZHIHUAN HUANG BOUEY; Fiscal Year: 2011
    ..aims are to: (1) describe and compare the prevalence of unprotected sexual practices and STIs (Chlamydia, gonorrhea, syphilis, HSV-2, and HBV) between migrant and non-migrant street walkers;(2) describe and compare the ..
  8. Drug Abuse, Incarceration &Health Disparities in HIV/AIDS: A Longitudinal Study
    Linda A Teplin; Fiscal Year: 2013
    ..incarceration history, and services received);(4) test the entire sample for HIV infection, chlamydia, and gonorrhea;and (5) administer a new module on incarceration, release, and re-entry...
  9. Randomized Trial of IFCBT-HIVPI to Prevent HIV Among Non-Injection Drug Users
    William W Latimer; Fiscal Year: 2013
    ..effects on primary (HIV sexual risk behaviors and HIV drug taking risk behaviors) and secondary (HIV, Chlamydia, gonorrhea, and trichomoniasis incidences and legal involvement, academic achievement, and employment) outcome domains will ..
  10. Duet cervical barrier device for maximizing protective efficacy of microbicides
    Richard Cone; Fiscal Year: 2009
    ..via ReProtect's BufferGel IND to pursue clinical trials of BufferGel-Duet for preventing STIs (chlamydia, gonorrhea, trichomoniasis, and HIV), BV, and for contraception...
  11. Molecular Targets in Peptidoglycan Synthesis
    Christopher Davies; Fiscal Year: 2013
    ..provided by applicant): Neisseria gonorrhoeae is the causative agent for the sexually transmitted disease gonorrhea and was responsible for over 350,000 infections in the U.S. in 2007...
  12. Preventing HIV/AIDS Among Teens in Juvenile Justice
    Geri R Donenberg; Fiscal Year: 2013
    ..occur at baseline, 6-, and 12-months post-treatment, and we will screen youth for three common STIs (Chlamydia, Gonorrhea, Trichamonas) at baseline and 12-month follow-up...
  13. Type IV secretion by Neisseria gonorrhoeae
    Joseph P Dillard; Fiscal Year: 2012
    ..provided by applicant): Neisseria gonorrhoeae is the causative agent of the sexually-transmitted disease gonorrhea as well as pelvic inflammatory disease, and disseminated gonococcal infection...
  14. Molecular analysis of oriT-independent transfer in the gonococcal R-plasmids
    LUIS TORRES-BAUZA; Fiscal Year: 2012
    ..For the first time, our group showed that the 5.2 kb beta-lactamase plasmid of Neisseria gonorrhea is mobilized by cointegration with several conjugative plasmids of Escherichia coli and the tet(M) gonococcal ..
  15. STI Risk among adolescent females: activity spaces and spatial mobility
    ELIZABETH ANN REED; Fiscal Year: 2013
    ..role of social spaces (locations where social interactions occur) and spatial mobility on risk for chlamydia and gonorrhea among adolescent girls living near the US-Mexico border...
  16. Interaction of Neisseria gonorrhoeae with polarized human endocervical epithelial
    Wenxia Song; Fiscal Year: 2013
    ..applicant): Neisseria gonorrhoeae, an obligate human pathogen, causes a common sexually transmitted infection, gonorrhea. While gonococci (GC) cause symptomatic inflammation of the genital tissue in men, GC infections in women are ..
  17. UNC-South China STD Research Training Center
    JOSEPH DAVID TUCKER; Fiscal Year: 2013
    ..The Center will focus on classical STDs (syphilis, gonorrhea, chlamydia, HIV, human papillomavirus) as well as hepatitis B and hepatitis C...
  18. Evolving HIV/STI risk environments of FSWs on the Mexico/U.S. Border
    Kimberly C Brouwer; Fiscal Year: 2013
    ..All will be tested for HIV, syphilis, gonorrhea, and Chlamydia and treated as needed. Follow-up interviews and testing will occur at months 6, 12, and 18...
  19. Safer sex intervention for male clients of female sex workers in Tijuana, Mexico
    Thomas L Patterson; Fiscal Year: 2013
    ..recruited in Tijuana where they will undergo a baseline CAPI-administered interview, STI testing (HIV, syphilis, gonorrhea, Chlamydia), and intervention counseling with follow-up interviews at 4, 8, and 12 months post-baseline ..
  20. Structural Topology of a Small Multidrug Resistant Efflux Pump
    Nathaniel J Traaseth; Fiscal Year: 2012
    ..Some of these infectious diseases include HIV, tuberculosis, meningitis, staphylococcal infection, influenza, gonorrhea, Candida, and malaria. Currently 5-10% of hospital patients develop an infection, leading to 1...
  21. Genetic Variation in genes involved in Neisseria gonorrhoeae LOS biosynthesis
    Daniel C Stein; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Neisseria gonorrhoeae is responsible for over 1 million cases of gonorrhea each year in the United States...
  22. Modulation of Virulence Determinants Contributing to Gonococcal Pathogenesis
    Daniel Williams; Fiscal Year: 2010
    Neisseria gonorrhoeae is a Gram-negative, strict human pathogen that causes the sexually transmitted disease, gonorrhea. The incidence of gonorrhea infections worldwide (estimated at over 60 million cases a year) and the ability of the ..
  23. Epidemiology and modeling of the population dynamics of influenza and antimicrobi
    Edward Goldstein; Fiscal Year: 2013
    ..5. Assessment of the factors behind the rise in antimicrobial resistance in N. gonorrhea, an evolving public health problem, using both epidemiological and molecular typing methods (an ongoing ..
  24. SOUTH AFRICAN ADOLESCENT HEALTH PROMOTION PROJECT
    JOHN BARTON JEMMOTT; Fiscal Year: 2010
    ..Urine specimens will be collected and tested for Chlamydia trachomatis, Neisseria gonorrhea, and Trichomonas vaginalis using DNA-amplification technology...
  25. Couples-Based HIV/STI Prevention for Injecting Drug Users in Kazakhstan
    Nabila El-Bassel; Fiscal Year: 2012
    ..biological outcomes are the rate of new HIV cases and new HCV cases, as well as the incidence of Chlamydia, gonorrhea, and syphilis over the 12-month post-intervention period...
  26. HIV/STI outcomes from male circumcision in men and female partners: Kisumu, Kenya
    SUPRIYA DINESH MEHTA; Fiscal Year: 2010
    ..Despite this, the 2-year HIV seroconversion rate was 2.1% for circumcised men. The combined incidence of gonorrhea, chlamydia, and trichomonas was high (8.34 per 100 person-years), and did not differ by circumcision status...
  27. LONGITUDINAL STUDY OF SUBSTANCE USE, INCARCERATION, AND STI IN THE US
    MARIA RABIA KHAN; Fiscal Year: 2010
    ..substance use on multiple (e 2) sexual partnerships and biologically confirmed infection with chlamydia, gonorrhea, or trichomoniasis in adulthood...
  28. The Elimination of Health Disparities through Translation Research
    Carol E Kaufman; Fiscal Year: 2010
    ..ages 15-19 bear a disproportionate share of most STDs, comprising 34% and 28% of all Chlamydia and Neisseria gonorrhea (gonorrhea) cases, respectively, reported in IHS services areas. This is due to a number of factors...
  29. Four-Arm RCT of Brief MI vs. Couples-Based HIV/STI Prevention in South Africa
    William W Latimer; Fiscal Year: 2013
    ..of each couple will be administered assessments with blood tested for HIV and urine tested for Chlamydia, gonorrhea, trichomoniasis, and drug use at baseline and 3-month, 6-month, and 12-month follow-up...
  30. Disparities in sexually transmitted infections among young women: Role of individ
    SARAH ELIZABETH WIEHE; Fiscal Year: 2010
    ..As different mechanisms may contribute to the spread of various STI differently, we will evaluate Chlamydia, gonorrhea, syphilis, and HIV independently and in combination...
  31. LpxC inhibitors as a novel class of antibiotics against N. gonorrhoeae
    Pei Zhou; Fiscal Year: 2013
    ..provided by applicant): Neisseria gonorrhoeae is the etiologic agent of the sexually transmitted infection, gonorrhea. Antibiotics are the mainstay in treating infections, but widespread resistance in N...
  32. Gonococcal interactions with human polymorphonuclear leukocytes
    Alison K Criss; Fiscal Year: 2011
    Neisseria gonorrhoeae (Gc) is a human-specific bacterial pathogen that causes the sexually transmitted disease gonorrhea. In infected individuals, massive numbers of polymorphonuclear leukocytes (PMNs) are recruited to the site of ..
  33. Survival of Neisseria gonorrhoeae after primary human neutrophil challenge
    Alison K Criss; Fiscal Year: 2013
    ..gonorrhoeae (Gc) is an obligate human bacterial pathogen and the cause of the sexually transmitted infection gonorrhea. Infection with Gc drives the recruitment of neutrophils (PMNs) and production of a characteristic purulent ..
  34. Universal Screening of HIV-Infected Persons for Gonorrhea and Chlamydia
    STEPHEN ARTHUR BERRY; Fiscal Year: 2013
    ..Tens of thousands of asymptomatic gonorrhea (GC) and chlamydia (CT) cases may go undetected each year among HIV-infected Americans engaged in medical care...
  35. Genomic epidemiology of Neisseria gonorrhoeae with elevated MICs to cefixime
    Yonatan H Grad; Fiscal Year: 2013
    ..N. gonorrhoeae, the causative agent of gonorrhea, has developed antibiotic resistance to each of the first line antibiotics used to treat it...
  36. Proyecto Parejas: HIV/STI Risks among FSWs and their Non-Commercial Partners
    Steffanie A Strathdee; Fiscal Year: 2013
    ..e., syphilis, gonorrhea, Chlamydia, HSV-2) and associated correlates at the individual and partner level;Aim 3: To prospectively ..
  37. Efficacy of HIV Posttest Support for ANC in South Africa
    Suzanne Maman; Fiscal Year: 2010
    ..and interview a cohort of 1,495 HIV-positive and HIV-negative participants to determine baseline biologic (Gonorrhea, Trichomonas vaginalis, Chlamydia), behavioral, and psychosocial characteristics;(3) randomize participants to ..
  38. Partners for Strong, Healthy Families (PSHF)
    Frank H Galvan; Fiscal Year: 2013
    ..Latino youth are 2.8 times more likely to contract chlamydia, 2.2 times more likely to contract gonorrhea, 2...
  39. HIV, HCV and STI Risk Associated with Nonmedical Use of Prescription Opioids
    Travis Wendel; Fiscal Year: 2013
    ..In addition, key objectives of this research will be to systematically document the HIV/HCV/Chlamydia and Gonorrhea risk and preventive behaviors, knowledge, testing practices and prevalence rates of NMU-PO young adults...
  40. MSM and Substances Cohort at UCLA Linking Infections Noting Effects (MASCULINE)
    Steven Shoptaw; Fiscal Year: 2013
    ..level risk in exposed and infected MMSM on acquisition of HIV and other sexually transmitted infections (STIs: gonorrhea, Chlamydia, syphilis, Hepatitis C (HCV));and (ii) the extent to which substance use in MMSM facilitates ..
  41. GONOCOCCI: GENETICS OF RESISTANCE TO PMN PROTEINS
    WILLIAM MAURICE SHAFER; Fiscal Year: 2013
    ..strict human pathogen that causes greater than sixty million cases worldwide of the sexually transmitted disease gonorrhea each year...
  42. Transcytosis of IgG in Genital Infections
    Xiaoping Zhu; Fiscal Year: 2010
    ..of immune protection for the genital tract, and will provide the basic knowledge essential for the prevention of other STDs, including human immunodeficiency virus, vaginitis, syphilis, gonorrhea, papillomavirus, Candida albican, etc.
  43. Evaluating a Structural and Behavioral HIV Risk Reduction Program for Black Men
    Jay G Silverman; Fiscal Year: 2013
    ..assess program impact on reduction in number of unprotected sex episodes and incident cases of STI (Chlamydia, gonorrhea, syphilis) via survey and STI testing, respectively, at baseline and 6 and 12 month follow-ups...
  44. The Role of Novel Bacteria in Male Urethritis
    Lisa E Manhart; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Urethritis is the most common male reproductive tract syndrome, yet once gonorrhea is accounted for, up to 50% of non-gonococcal urethritis (NGU) cases have no known etiology, suggesting the presence ..
  45. Multicomponent Intervention to Reduce Sexual Risk and Substance Use
    Jeffrey T Parsons; Fiscal Year: 2013
    ..We will conduct biological testing (HIV, Chlamydia, gonorrhea, and syphilis) and collect self-report data to evaluate intervention efficacy...
  46. Epidemiology of Gonoccoccal Subpopulations
    Jonathan M Zenilman; Fiscal Year: 2010
    b>Gonorrhea (GC) rates remain stubbornly high. Hyperendemic core groups are believed essential for continued transmission. Core groups are defined geographically or through behavioral risk factors, such as repeated gonorrhea incidence...
  47. Mechanisms of antibiotic action in Neisseria gonorrhoeae.
    Robert A Nicholas; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): N. gonorrhoeae, the causative agent of gonorrhea, is responsible for -300,000 infections in the U.S. and over 6 million globally...
  48. Southeastern Sexually Transmitted Infections Cooperative Research Center
    Philip Frederick Sparling; Fiscal Year: 2013
    ..Five synergistic projects explore molecular pathogenesis, immunobiology and possible vaccines for gonorrhea, and the sixth project focuses on development of a promising vaccine for H. ducreyi...
  49. Bacterial STI and Innate Immunity in HIV Susceptibility
    GARY JARVIS; Fiscal Year: 2009
    ..that gonococcal and chlamydial infections facilitate the transmission of HIV infection and that control of gonorrhea and chlamydia needs to remain high on the agenda of HIV control programs...
  50. Repeat STI Patients: Tailored Socio-Contextual Intervention to Reduce HIV Risk
    Lance S Weinhardt; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Repeat sexually transmitted infections (STI), such as Chlamydia, gonorrhea, trichomoniasis, and syphilis indicate persistent elevated risk activity for HIV, and repeated STI infections increase the ..
  51. HIV, Risk Behaviors, and Stigma in High Risk Tanzanian Men
    Michael W Ross; Fiscal Year: 2011
    ..Linked to this will be biological data on HIV, syphilis and urethral and rectal gonorrhea and Chlamydia...
  52. A multimedia, group-based clinical care and support model to increase dual protec
    Melissa Kottke; Fiscal Year: 2013
    ..intervention will experience lower incidence of biologic outcomes (unintended pregnancy, Chlamydia and/or gonorrhea) than participants in the control group...
  53. PS08-002, DEV AND TESTING OF HIV PREV INTERVENTION TARGETING BLACK MSM/W
    MARIA ISABEL FERNANDEZ; Fiscal Year: 2011
    ..will complete behavioral assessments using ACASI and provide urine and blood specimens to test for chlamydia, gonorrhea, and syphilis at baseline, immediate post and 3 month post intervention...
  54. Molecular Epidemiology of N. gonorrhoeae
    RAPHAEL PAUL contact VISCIDI; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Gonorrhea is the second most common, notifiable disease in the United States. In 2005, gonorrhea rates began to rise, highlighting failure of current control efforts...
  55. Expedited Partner Therapy and STI Control for MSM in Peru
    Thomas J Coates; Fiscal Year: 2012
    ..by applicant): Expedited Partner Therapy (EPT) has been shown to reduce rates of persistent or recurrent gonorrhea and chlamydia infection in heterosexual patients, but has not been evaluated for use among men who have sex with ..
  56. Structural Factors to Lower Alcohol-Related HIV Risk
    B R Simon Rosser; Fiscal Year: 2010
    ..most driving heavy alcohol use and ARHR, and thus contribute to male-male transmission of HIV, syphilis and gonorrhea. If so, the growing utilization of gay e-environments should lower risk...
  57. Adapting Project S.A.F.E.: Reducing STD/HIV Risk in Women Prisoners
    CATHERINE I FOGEL; Fiscal Year: 2011
    ..598 incarcerated women to determine its efficacy in decreasing risk for non-viral STD infections (chlamydia, gonorrhea, and trichomonas), decreasing sexual risk behaviors and increasing risk reduction practices...
  58. The affect of hormones and oxygen-limitation on gonococcal pathophysiology
    Jennifer L Edwards; Fiscal Year: 2012
    ..severe, consequences as a result of cervical infection with Neisseria gonorrhoeae, the bacterium that causes gonorrhea. The focus of this application is to define the effect of steroid hormones and oxygen limitation to gonococcal ..
  59. Pharyngeal gonorrhea among young people: Implication for prevention
    Marjan Javanbakht; Fiscal Year: 2013
    ..Despite current and ongoing prevention efforts, rates of sexually transmitted infections (STIs), including gonorrhea among young people remains high...
  60. Couples-Based HIV/STI Prevention for Drug-Involved, African American MSM
    Elwin Wu; Fiscal Year: 2013
    ..to WP;(2) to test whether participants assigned to CNU have lower cumulative incidence of STIs-chlamydia and gonorrhea-confirmed via biological assay compared to participants assigned to WP;and (3) to test whether participants ..
  61. HPV Epidemiology and Response to Screening (HEARTS)
    Elise D Riley; Fiscal Year: 2010
    ..The impact of repeated exposure to HPV, as well as the impact of co-infections like HIV, HCV, gonorrhea, and Chlamydia, on the natural history of HPV infection and HPV-associated disease, is unclear in this ..
  62. Mechanisms Underlying Preterm Birth in Minority Women
    Susan Gennaro; Fiscal Year: 2012
    ..immune function (vaginal cytokines), health behaviors (BMI and smoking), and infection (including Chlamydia, gonorrhea, and bacterial vaginosis), in differentiating those AA women who will deliver preterm, from those who will ..
  63. IMPACT OF SOCIAL NETWORKS ON SYPHILIS TRANSMISSION
    Anne Rompalo; Fiscal Year: 2004
    ..The investigators are currently funded to examine the role of social context on gonorrhea transmission...
  64. Geography, networks, and risk in disease transmission
    Richard Rothenberg; Fiscal Year: 2009
    ..prevalence and incidence of seven sexually transmitted and blood-borne infections (HIV, HCV, HSV-2, Syphilis, Gonorrhea, Chlamydial infection, and Trichomoniasis) in the areas with high and low burden of HIV...
  65. CR3 IN CELL ACTIVATION AND PHAGOCYTOSIS OF GONORRHEA
    ROBIN INGALLS; Fiscal Year: 2001
    ..Finally, we will use somatic cell mutagenesis techniques to generate phagocytosis mutants in the CR3- transfected CHO line. Complementation analysis can then be used to identify genes essential for phagocytosis in human monocytes. ..
  66. Prevention of Infertility in Women With Subclinical PID
    HAROLD WIESENFELD; Fiscal Year: 2007
    ..Subclinical PID is present in 25% of women with gonorrhea or chlamydia, and one in seven women with bacterial vaginosis, despite the absence of symptoms of acute PID...
  67. INTRACELLULAR FATE OF NEISSERIA GONORRHOEAE
    Richard Rest; Fiscal Year: 2000
    ..Adapted from the applicant's abstract): Neisseria gonorrhoeae (the gonococcus) is the etiologic agent of gonorrhea. Gonorrhea, and its dramatically more serious complications, salpingitis and PID (pelvic inflammatory disease), ..
  68. HETEROSEXUAL TRANSMISSION AND THE NATURAL HISTORY OF HIV
    Susan Allen; Fiscal Year: 2000
    ..Only 5% of seroconvertors in our previous studies of Rwandan women had a genital ulcer or gonorrhea. Vaginal discharge was far more common and was associated with an increased risk of seroconversion in ..
  69. ECTOPY, HORMONAL CONTRACEPTION AND STD'S IN ADOLESCENTS
    Ligia Peralta; Fiscal Year: 2004
    ..zone; 3) the relation between the size of the area of ectopy/T zone and STD acquisition, including chlamydia, gonorrhea, trichomonas and HPV; and 4) the risk of STDs in OC users compared to DMPA users stratified by the extent of ..
  70. HIV AND STIS IN YOUNG ADULTS: A NETWORK APPROACH
    W Morris; Fiscal Year: 2003
    ..Specimens will be tested for four STIs in Survey 2000: Chlamydia trachomatis (Ct), Neisseria gonorrhea (GC), Trichomonas vaginalis (Tv), and human immunodeficiency virus (HIV)...
  71. Prevention Technologies for Sexual and Reproductive Health Conference
    Susan Ivey; Fiscal Year: 2009
    ..Every year, 340 million people acquire new gonorrhea, syphilis, Chlamydia, or trichomonas infections...
  72. PID IN IUD VS INJECTABLE CONTRACEPTIVE USERS PILOT STUDY
    Paul Feldblum; Fiscal Year: 2001
    ..of our four participating sites for a subsequent Main Clinical Trial, including: baseline prevalence of cervical gonorrhea and chlamydia among 100 study participants randomized to IUD or DMPA use; baseline prevalence of cervical ..
  73. Rapid Point-of-Care Diagnostic Test for Chlamydia and Gonorrhea
    DAVID DOLINGER; Fiscal Year: 2007
    ..Chlamydia and gonorrhea are the first and second most frequently reported sexually transmitted diseases in the United States, and around ..
  74. Mechanisms of Host Responses in Gonorrhea
    Tie Chen; Fiscal Year: 2006
    unreadable] DESCRIPTION (provided by applicant): Neisseria gonorrhoeae (gonococci, GC) cause gonorrhea and pelvic inflammatory disease (PID)...