Genomes and Genes
Summary: Infections with bacteria of the genus CHLAMYDIA.
Publications286 found, 100 shown here
- Chlamydial persistence: beyond the biphasic paradigmRichard J Hogan
Infectious Diseases Program and Cooperative Research Centre for Diagnostics, School of Life Sciences, Queensland University of Technology, Brisbane, Australia
Infect Immun 72:1843-55. 2004
- Whole-genome analysis of diverse Chlamydia trachomatis strains identifies phylogenetic relationships masked by current clinical typingSimon R Harris
Pathogen Genomics, The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK
Nat Genet 44:413-9, S1. 2012..We used our phylogenetic framework to show how genetic exchange has manifested itself in ocular, urogenital and LGV C. trachomatis strains, including the epidemic LGV serotype L2b...
- Chlamydia trachomatis persistence in vitro: an overviewPriscilla B Wyrick
Department of Microbiology, J H Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA
J Infect Dis 201:S88-95. 2010....
- Effectiveness of yearly, register based screening for chlamydia in the Netherlands: controlled trial with randomised stepped wedge implementationIngrid V F van den Broek
Unit of Epidemiology and Surveillance, RIVM Centre for Infectious Disease Control Netherlands, PO Box 1, 3720 BA Bilthoven, Netherlands
BMJ 345:e4316. 2012..To evaluate the effectiveness of register based, yearly chlamydia screening...
- Risk of sequelae after Chlamydia trachomatis genital infection in womenCatherine L Haggerty
Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA 15261, USA
J Infect Dis 201:S134-55. 2010..trachomatis infection; better tools to measure PID and tubal damage; and studies on the natural history of repeated chlamydial infections are needed...
- Histopathologic changes related to fibrotic oviduct occlusion after genital tract infection of mice with Chlamydia muridarumAnita A Shah
Department of Microbiology, Chicago College of Osteopathic Medicine, Midwestern University, 555 31st Street, Downers Grove, IL 60515, USA
Sex Transm Dis 32:49-56. 2005..We sought to determine if intraluminal occluding fibrosis of the oviduct occurs after urogenital Chlamydia muridarum infection in mice...
- Prevalence of Chlamydia trachomatis: results from the first national population-based survey in FranceV Goulet
Institut de Veille Sanitaire, 12 Rue du Val d Osne, Saint Maurice 94410, France
Sex Transm Infect 86:263-70. 2010..Few studies have estimated Chlamydia trachomatis (CT) prevalence in the general population, most prevalence studies being based on people already attending healthcare settings...
- Sexual behaviour in Britain: reported sexually transmitted infections and prevalent genital Chlamydia trachomatis infectionK A Fenton
Centre for Infectious Disease Epidemiology, Department of Primary Care, Royal Free and University College London Medical School, London, UK
Lancet 358:1851-4. 2001..The results have potentially wide application for proposed chlamydia screening programmes which, given the demonstrated prevalence, must now proactively seek to involve men...
- The cellular paradigm of chlamydial pathogenesisRichard S Stephens
Division of Infectious Diseases, School of Public Health, 140 Earl Warren Hall, University of California, Berkeley 94720, USA
Trends Microbiol 11:44-51. 2003....
- Mechanisms of host cell exit by the intracellular bacterium ChlamydiaKevin Hybiske
Division of Infectious Diseases, School of Public Health, University of California, Berkeley, CA 94720, USA
Proc Natl Acad Sci U S A 104:11430-5. 2007..The participation of Rho was unique in that it functioned late in extrusion. The dual nature of release characterized for Chlamydia has not been observed as a strategy for intracellular bacteria...
- Secretion of proinflammatory cytokines by epithelial cells in response to Chlamydia infection suggests a central role for epithelial cells in chlamydial pathogenesisS J Rasmussen
Francis I Proctor Foundation, University of California, San Francisco 94143, USA
J Clin Invest 99:77-87. 1997..These findings suggest a novel pathophysiologic concept wherein the acute host response to Chlamydia at mucosal surfaces is primarily initiated and sustained by epithelial cells, the first and major targets of chlamydial infection...
- Transmission of Chlamydia trachomatis through sexual partnerships: a comparison between three individual-based models and empirical dataChristian L Althaus
Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland
J R Soc Interface 9:136-46. 2012..We suggest that the Gini coefficient is a useful measure for calibrating infectious disease models that include risk structure and highlight the need to estimate this measure for other STIs...
- The role of reinfection and partner notification in the efficacy of Chlamydia screening programsJanneke C M Heijne
Division of Clinical Epidemiology and Biostatistics, Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland
J Infect Dis 203:372-7. 2011..Effective management of sex partners to prevent reinfection might need to be strengthened in chlamydia control programs...
- Typing Chlamydia trachomatis: from egg yolk to nanotechnologyLisbeth Nørum Pedersen
Department of Clinical Microbiology, Aarhus University Hospital, Skejby, Denmark
FEMS Immunol Med Microbiol 55:120-30. 2009..However, it is important to realize that culture of C. trachomatis may still be needed to detect and characterize new variants of C. trachomatis...
- Tumor necrosis factor alpha production from CD8+ T cells mediates oviduct pathological sequelae following primary genital Chlamydia muridarum infectionAshlesh K Murthy
South Texas Center for Emerging Infectious Diseases, Department of Biology, University of Texas at San Antonio, San Antonio, Texas 78249, USA
Infect Immun 79:2928-35. 2011..These results provide compelling new evidence supporting the contribution of CD8(+) T cells and TNF-α production to Chlamydia-induced reproductive tract sequelae...
- Duration of untreated, uncomplicated Chlamydia trachomatis genital infection and factors associated with chlamydia resolution: a review of human studiesWilliam M Geisler
Department of Medicine, Division of Infectious Diseases, University of Alabama at Birmingham, Birmingham, AL 35294 0007, USA
J Infect Dis 201:S104-13. 2010..This article summarizes the key questions posed and the evidence reviewed on the duration of untreated, uncomplicated genital chlamydial infection in humans and the factors associated with chlamydia resolution...
- Pathogenesis of genital tract disease due to Chlamydia trachomatisToni Darville
Departments of Pediatrics and Immunology, University of Pittsburgh Medical Cente, USA
J Infect Dis 201:S114-25. 2010....
- The natural history of untreated Chlamydia trachomatis infection in the interval between screening and returning for treatmentWilliam M Geisler
Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294 0007, USA
Sex Transm Dis 35:119-23. 2008..An improved understanding of chlamydial natural history may influence recommendations for elements of control efforts such as chlamydia screening frequency or time parameters for partner notification...
- Expression of matrix metalloproteinases subsequent to urogenital Chlamydia muridarum infection of miceK H Ramsey
Department of Microbiology and Immunology, Chicago College of Osteopathic Medicine, Midwestern University, IL 60516, USA
Infect Immun 73:6962-73. 2005..These differences may account for disparate outcomes with regard to chronic sequelae of the disease...
- Using quantitative polymerase chain reaction to correlate Chlamydia pecorum infectious load with ocular, urinary and reproductive tract disease in the koala (Phascolarctos cinereus)C Wan
Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, Brisbane, Australia
Aust Vet J 89:409-12. 2011..These results suggest a complex disease pathogenesis and clinical course in C. pecorum-infected koalas...
- Chlamydia trachomatis trends in the United States among persons 14 to 39 years of age, 1999-2008S Deblina Datta
National Center for HIV AIDS, Viral Hepatitis, STD and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA
Sex Transm Dis 39:92-6. 2012..We report the first population-based assessment of national trends in chlamydia prevalence in the United States...
- The hypothetical protein CT813 is localized in the Chlamydia trachomatis inclusion membrane and is immunogenic in women urogenitally infected with C. trachomatisChaoqun Chen
Department of Microbiology and Immunology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, Texas 78229, USA
Infect Immun 74:4826-40. 2006..Thus, the CT813 protein may represent an important candidate for understanding C. trachomatis pathogenesis and developing intervention and prevention strategies for controlling C. trachomatis infection...
- Interleukin-13 promotes susceptibility to chlamydial infection of the respiratory and genital tractsKelly L Asquith
Centre for Asthma and Respiratory Disease and Hunter Medical Research Institute, University of Newcastle, Newcastle, Australia
PLoS Pathog 7:e1001339. 2011..Collectively our findings demonstrate that innate IL-13 release promotes infection that results in enhanced inflammation and have broad implications for the treatment of chlamydial infections and IL-13-associated diseases...
- Chlamydia trachomatis genital tract infection of antibody-deficient gene knockout miceH Su
Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA
Infect Immun 65:1993-9. 1997..Therefore, these data suggest that both humoral and cell-mediated immune responses were important mediators of immune protection in this model, though cell-mediated immune responses appear to play a more dominant role...
- Epidemiology of Chlamydia trachomatis infection in women and the cost-effectiveness of screeningJ A Land
Department of Obstetrics and Gynaecology, University Medical Center Groningen, Groningen, The Netherlands
Hum Reprod Update 16:189-204. 2010..There is considerable debate over the exact complication rates after chlamydia infections, and more precise estimates of PID and tubal infertility are needed, for instance to be inserted in ..
- Evidence for long-term cervical persistence of Chlamydia trachomatis by omp1 genotypingD Dean
Children s Hospital Oakland Research Institute, Oakland, CA 94609, USA
J Infect Dis 182:909-16. 2000..These data demonstrate that cervical infections with C class serovars can persist for years and may have specific biologic properties that allow for modulation of the major outer membrane protein in response to immune selection...
- Toll-like receptor-2, but not Toll-like receptor-4, is essential for development of oviduct pathology in chlamydial genital tract infectionToni Darville
Division of Pediatric Infectious Diseases, Arkansas Children s Hospital and University of Arkansas for Medical Sciences, Little Rock, AR 72202, USA
J Immunol 171:6187-97. 2003..TLR2 is an important mediator in the innate immune response to C. trachomatis infection and appears to play a role in both early production of inflammatory mediators and development of chronic inflammatory pathology...
- Prevalence of chlamydial and gonococcal infections among young adults in the United StatesWilliam C Miller
Department of Medicine, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill 27599 7435, USA
JAMA 291:2229-36. 2004..Although screening for Chlamydia trachomatis is widely recommended among young adult women, little information is available regarding the prevalence of chlamydial and gonococcal infections in the general young adult population...
- Genital Chlamydia trachomatis infectionsC Bebear
Laboratoire de Bactériologie EA 3671, Infections Humaines à Mycoplasmes et Chlamydiae, CNR des Infections à Chlamydiae, Universite Victor Segalen Bordeaux 2, Bordeaux, France
Clin Microbiol Infect 15:4-10. 2009..Single-dose therapy has been a significant development for treatment of an uncomplicated infection of the patient and his or her sexual partner...
- Specific chlamydial inclusion membrane proteins associate with active Src family kinases in microdomains that interact with the host microtubule networkJeffrey Mital
Host Parasite Interactions Section, Laboratory of Intracellular Parasites, National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratories, NIAID, NIH, Hamilton, MT 59840, USA
Cell Microbiol 12:1235-49. 2010..Together, the data suggest that a specific structure on the C. trachomatis inclusion membrane may be responsible for the known interactions of chlamydiae with the microtubule network and resultant effects on centrosome stability...
- Randomised controlled trial of screening for Chlamydia trachomatis to prevent pelvic inflammatory disease: the POPI (prevention of pelvic infection) trialPippa Oakeshott
Division of Community Health Sciences, St George s, University of London SW17 0RE
BMJ 340:c1642. 2010..To determine whether screening and treating women for chlamydial infection reduces the incidence of pelvic inflammatory disease over the subsequent 12 months...
- Caspase-1 contributes to Chlamydia trachomatis-induced upper urogenital tract inflammatory pathologies without affecting the course of infectionWen Cheng
Department of Microbiology and Immunology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
Infect Immun 76:515-22. 2008....
- Animal chlamydioses and zoonotic implicationsD Longbottom
Moredun Research Institute, Pentlands Science Park, Bush Loan, Penicuik, Midlothian EH26 0PZ, UK
J Comp Pathol 128:217-44. 2003
- Chlamydia trachomatis in the United Kingdom: a systematic review and analysis of prevalence studiesE J Adams
Statistics, Modelling and Economics Department, Communicable Disease Surveillance Centre, Health Protection Agency, 61 Colindale Avenue, London NW9 5EQ, UK
Sex Transm Infect 80:354-62. 2004....
- Rectal gonorrhea and chlamydia reinfection is associated with increased risk of HIV seroconversionKyle T Bernstein
Epidemiology, Research and Surveillance, STD Prevention and Control Services, San Francisco Department of Public Health, San Francisco, CA 94103, USA
J Acquir Immune Defic Syndr 53:537-43. 2010..HIV infection continues to disproportionately affect men who have sex with men (MSM). Identification of modifiable risk factors for HIV infection among MSM is critical for effective prevention...
- Efficacy of interventions to increase the uptake of chlamydia screening in primary care: a systematic reviewRebecca J Guy
The Kirby Institute, Sydney, New South Wales, Australia
BMC Infect Dis 11:211. 2011As most genital chlamydia infections are asymptomatic, screening is the main way to detect and cases for treatment...
- Using educational outreach and a financial incentive to increase general practices' contribution to chlamydia screening in South-East London 2003-2011Sebastian Kalwij
Amersham Vale Practice, Waldron Health Centre, London SE14 6LD, United Kingdom
BMC Public Health 12:802. 2012....
- Knowledge of Chlamydia trachomatis among men and women approached to participate in community-based screening, Scotland, UKKaren Lorimer
Institute for Applied Health Research, Glasgow Caledonian University, Glasgow, UK
BMC Public Health 10:794. 2010..This study aimed to determine the level of awareness and knowledge of chlamydia among young people who were being approached in a variety of community settings and offered opportunistic screening...
- Trends in chlamydia and gonorrhea positivity among heterosexual men and men who have sex with men attending a large urban sexual health service in Australia, 2002-2009Lenka A Vodstrcil
Melbourne School of Population Health, The University of Melbourne, Vic, Australia
BMC Infect Dis 11:158. 2011..To determine whether chlamydia positivity among heterosexual men (MSW) and chlamydia and gonorrhea positivity among men who have sex with men (MSM), are changing...
- Chlamydia infection, pelvic inflammatory disease, ectopic pregnancy and infertility: cross-national studyNicole Bender
Institute of Social and Preventive Medicine, University of Bern, Bern CH 3012, Switzerland
Sex Transm Infect 87:601-8. 2011....
- Immunity to murine chlamydial genital infectionRichard P Morrison
Department of Microbiology, Montana State University, Bozeman 59717, USA
Infect Immun 70:2741-51. 2002
- Generation of targeted Chlamydia trachomatis null mutantsLaszlo Kari
Laboratory of Intracellular Parasites, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
Proc Natl Acad Sci U S A 108:7189-93. 2011..Additionally, this strategy could be applied to other medically important bacterial pathogens with no or difficult genetic systems...
- Coverage and uptake of systematic postal screening for genital Chlamydia trachomatis and prevalence of infection in the United Kingdom general population: cross sectional studyJohn Macleod
Department of Primary Care and General Practice, University of Birmingham, Birmingham B15 2TT
BMJ 330:940. 2005..To measure the coverage and uptake of systematic postal screening for genital Chlamydia trachomatis and the prevalence of infection in the general population in the United Kingdom. To investigate factors associated with these measures...
- Mice deficient in MyD88 Develop a Th2-dominant response and severe pathology in the upper genital tract following Chlamydia muridarum infectionLili Chen
Department of Microbiology and Immunology, University of Texas Health Science Center, San Antonio, TX 78229, USA
J Immunol 184:2602-10. 2010....
- Internet-based screening for sexually transmitted infections to reach nonclinic populations in the community: risk factors for infection in menShua J Chai
Department of Epidemiology, Johns Hopkins School of Public Health, Baltimore, MD 21205, USA
Sex Transm Dis 37:756-63. 2010..We studied whether internet-based screening was acceptable and reached a high-risk population, and what risk factors were associated with STI positivity...
- Comparative model-based analysis of screening programs for Chlamydia trachomatis infectionsM Kretzschmar
Department of Infectious Disease Epidemiology, National Institute of Public Health and the Environment RIVM, Bilthoven, The Netherlands
Am J Epidemiol 153:90-101. 2001..Partner referral contributes substantially to prevalence reduction...
- Endogenous IFN-gamma production is induced and required for protective immunity against pulmonary chlamydial infection in neonatal miceMadhulika Jupelli
South Texas Center for Emerging Infectious Diseases, Department of Biology, University of Texas, San Antonio, TX 78249, USA
J Immunol 180:4148-55. 2008..The enhanced IFN-gamma induction in the immature neonatal lung also may be relevant to the development of respiratory sequelae in adult life...
- Rationale, design, and results of the first screening round of a comprehensive, register-based, Chlamydia screening implementation programme in the NetherlandsJan E A M van Bergen
STI AIDS Netherlands, Amsterdam, The Netherlands
BMC Infect Dis 10:293. 2010..Here, we describe the rationale, design, and implementation of a Chlamydia screening demonstration programme...
- Who participates in the Dutch Chlamydia screening? A study on demographic and behavioral correlates of participation and positivityEline L M Op de Coul
Epidemiology and Surveillance Unit, Centre for Infectious Disease Control, National Institute of Public Health and the Environment, Bilthoven, The Netherlands
Sex Transm Dis 39:97-103. 2012..We studied who was reached in the first screening round by relating participation and chlamydia positivity to sociodemographic and sexual risk factors...
- Repeated Chlamydia trachomatis genital infections in adolescent womenByron E Batteiger
Divisions of Infectious Diseases, Indiana University School of Medicine, Indianapolis, Indiana 46202 5112, USA
J Infect Dis 201:42-51. 2010..Repeated Chlamydia trachomatis infections are common among young sexually active women. The relative frequency of reinfection and antibiotic treatment failure is undefined...
- Performance of the Abbott RealTime CT/NG for detection of Chlamydia trachomatis and Neisseria gonorrhoeaeC A Gaydos
Johns Hopkins University, 855 North Wolfe St, 530 Rangos Building, Baltimore, MD 21205, USA
J Clin Microbiol 48:3236-43. 2010..trachomatis and N. gonorrhoeae dual detection with high sensitivity and specificity. The automated assay provides a useful alternative nucleic acid amplification assay for clinical laboratories and clinicians...
- Hypoxia abrogates antichlamydial properties of IFN-γ in human fallopian tube cells in vitro and ex vivoAnna Roth
Institute of Medical Microbiology and Hygiene, Center for Structural and Cell Biology in Medicine, University of Luebeck, 23538 Luebeck, Germany
Proc Natl Acad Sci U S A 107:19502-7. 2010..trachomatis depend on the environmental oxygen supply, which could explain inadequate bacterial clearance and subsequent chronic infections eventually occurring in the UGT of women...
- The arrested immunity hypothesis and the epidemiology of chlamydia controlRobert C Brunham
Sex Transm Dis 35:53-4. 2008
- The Chlamydia trachomatis plasmid is a transcriptional regulator of chromosomal genes and a virulence factorJohn H Carlson
Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 903 South 4th Street, Hamilton, MT 59840, USA
Infect Immun 76:2273-83. 2008..Our findings have important implications in understanding a role for the plasmid in the pathogenesis of human infection and disease...
- Vaccination with the Chlamydia trachomatis major outer membrane protein can elicit an immune response as protective as that resulting from inoculation with live bacteriaSukumar Pal
Department of Pathology and Laboratory Medicine, Medical Sciences I, Room D440, University of California, Irvine, Irvine, CA 92697 4800, USA
Infect Immun 73:8153-60. 2005..05). In conclusion, immunization with a purified preparation of the MOMP is as effective as vaccination with viable C. trachomatis in eliciting a protective immune response against a genital challenge in mice...
- Isolates of Chlamydia trachomatis that occupy nonfusogenic inclusions lack IncA, a protein localized to the inclusion membraneR J Suchland
Division of Allergy and Infectious Diseases, School of Medicine, University of Washington, Seattle, Washington, USA
Infect Immun 68:360-7. 2000..trachomatis isolates that form nonfusing inclusions; the variant phenotype is associated with the absence of detectable IncA and with an altered incA sequence that modifies the characteristic hydrophobic domain of the IncA protein...
- Modelling the effectiveness of chlamydia screening in EnglandK M E Turner
Health Protection Agency, Centre for Infections, 61 Colindale Ave, Colindale, London NW9 5EQ, UK
Sex Transm Infect 82:496-502. 2006..Mathematical models can incorporate these non-linear effects and estimate the likely impact of different screening programmes and identify areas where more data are needed...
- Predicting phenotype and emerging strains among Chlamydia trachomatis infectionsDeborah Dean
Children s Global Health Initiativ, Children s Hospital Oakland Research Institute, Oakland, California 94609, USA
Emerg Infect Dis 15:1385-94. 2009..Multilocus and SNP typing can now be used to detect diverse and emerging C. trachomatis strains for epidemiologic and evolutionary studies of trachoma and STI populations worldwide...
- Interleukin-1 is the initiator of Fallopian tube destruction during Chlamydia trachomatis infectionMalene Hvid
Institute of Medical Microbiology and Immunology, University of Aarhus, The Bartholin Building, 8000 Aarhus C, Denmark
Cell Microbiol 9:2795-803. 2007..trachomatis infection. Because leukocytes are absent in the ex vivo model, this study strongly indicates that IL-1 is the initial proinflammatory cytokine activated by C. trachomatis infection...
- Transmission dynamics of Chlamydia trachomatis affect the impact of screening programmesChristian L Althaus
Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland
Epidemics 2:123-31. 2010..However, due to the slower turnover of the infection, a substantial reduction in prevalence can only be achieved after screening for several years or decades...
- Acceptability of the internet-based Chlamydia screening implementation in the Netherlands and insights into nonresponseKatie E Greenland
Epidemiology and Surveillance Unit, Centre for Infectious Disease Control, National Institute of Public Health and the Environment, Bilthoven, The Netherlands
Sex Transm Dis 38:467-74. 2011....
- Chlamydia trachomatis strains and virulence: rethinking links to infection prevalence and disease severityGerald I Byrne
Department of Molecular Sciences, University of Tennessee Health Science Center, Memphis, TN 38163, USA
J Infect Dis 201:S126-33. 2010....
- Restricted fusion of Chlamydia trachomatis vesicles with endocytic compartments during the initial stages of infectionMarci A Scidmore
Host Parasite Interactions Section, Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, Montana 59840, USA
Infect Immun 71:973-84. 2003....
- High frequency of chlamydial co-infections in clinically healthy sheep flocksHannah Lenzko
Institut für bakterielle Infektionen und Zoonosen, Friedrich Loeffler Institut, Naumburger Strasse 96a, 07743 Jena, Germany
BMC Vet Res 7:29. 2011..Seven vaccinated flocks were reviewed separately...
- Chlamydia trachomatis uses host cell dynein to traffic to the microtubule-organizing center in a p50 dynamitin-independent processScott S Grieshaber
Host Parasite Interactions Section, Laboratory of Intracellular Parasites, NIAID, NIH, Rocky Mountain Laboratories, Hamilton, MT 59840, USA
J Cell Sci 116:3793-802. 2003....
- The natural course of Chlamydia trachomatis infection in asymptomatic Colombian women: a 5-year follow-up studyMonica Molano
Department of Pathology, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
J Infect Dis 191:907-16. 2005..4 [95% CI, 0.1-0.9]), compared with that for serovars of the intermediate group (F and G). At 4 years of follow-up, 94% of the women had cleared their infections...
- Australian general practitioner chlamydia testing rates among young peopleFabian Y S Kong
Centre for Population Health, Burnet Institute, Melbourne, Vic, Australia
Med J Aust 194:249-52. 2011..To describe the proportion of 16-29-year-olds tested for chlamydia by Australian general practitioners in a 12-month period...
- Risk of cervical cancer associated with Chlamydia trachomatis antibodies by histology, HPV type and HPV cofactorsMargaret M Madeleine
Program in Epidemiology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
Int J Cancer 120:650-5. 2007..0-5.1), but not for the 4 types (C, F, H, and K) that were present at very low prevalence in this population. There was an increased risk of SCC, but not AC, associated with antibodies to C. trachomatis that was not serotype specific...
- Toll-like receptor 2 activation by Chlamydia trachomatis is plasmid dependent, and plasmid-responsive chromosomal loci are coordinately regulated in response to glucose limitation by C. trachomatis but not by C. muridarumCATHERINE M O'CONNELL
Department of Pediatrics, Children s Hospital of Pittsburgh of UPMC, 3705 Fifth Avenue, Pittsburgh, PA 15213, USA
Infect Immun 79:1044-56. 2011..Glucose-limited C. trachomatis displayed reduced TLR2 stimulation in an in vitro assay. During human chlamydial infection, glucose limitation may decrease chlamydial virulence through its effects on plasmid-responsive chromosomal genes...
- Gonorrhea and chlamydia in the United States among persons 14 to 39 years of age, 1999 to 2002S Deblina Datta
Division of STD Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
Ann Intern Med 147:89-96. 2007..Nationally representative surveys of chlamydia and gonorrhea are an important measure of disease burden and progress of screening programs...
- Simplifying chlamydia testing: an innovative Chlamydia trachomatis testing approach using the internet and a home sampling strategy: population based studyD P Novak
Department of Public Health and Clinical Medicine, Family Medicine, University of Umea, SE 901 85 Umea, Sweden
Sex Transm Infect 82:142-7; discussion 152-3. 2006..To investigate factors associated with these measures...
- A predominant role for antibody in acquired immunity to chlamydial genital tract reinfectionSandra G Morrison
Division of Infectious Diseases, Department of Medicine, University of Alabama, Birmingham 35294 0007, USA
J Immunol 175:7536-42. 2005..These results impact our understanding of immunity to chlamydial genital infection and may provide important insight into vaccine development...
- Actin and intermediate filaments stabilize the Chlamydia trachomatis vacuole by forming dynamic structural scaffoldsYadunanda Kumar
Department of Molecular Genetics and Microbiology and Center for Microbial Pathogenesis, Duke University Medical Center, Durham, NC 27710, USA
Cell Host Microbe 4:159-69. 2008..We propose that Chlamydia has co-opted the function of F-actin and IFs to stabilize the inclusion with a dynamic, structural scaffold while minimizing the exposure of inclusion contents to cytoplasmic innate immune-surveillance pathways...
- Keeping participants on board: increasing uptake by automated respondent reminders in an Internet-based chlamydia screening in the NetherlandsNynke F B Dokkum
Cluster of Infectious Diseases, Amsterdam Health Service, Amsterdam, The Netherlands
BMC Public Health 12:176. 2012....
- "...they should be offering it": a qualitative study to investigate young peoples' attitudes towards chlamydia screening in GP surgeriesAngela H Hogan
Health Protection Agency, Primary Care Unit, Gloucester Royal Hospital, Gloucester, UK
BMC Public Health 10:616. 2010..This study aimed to identify the attitudes to, and preferences for, chlamydia screening in 15-24 year old men and women attending GP surgeries (the target group)...
- Evaluation of the Abbott RealTime CT/NG assay in comparison to the Roche Cobas Amplicor CT/NG assayAnnie Cheng
Department of Pathology, Beth Israel Deaconess Medical Center, 330 Brookline Ave, YA309, Boston, MA 02215, USA
J Clin Microbiol 49:1294-300. 2011..gonorrhoeae and small amounts of C. trachomatis organisms. In summary, we conclude that the Abbott RealTime CT/NG assay is an accurate and automated new addition to the available testing options for C. trachomatis and N. gonorrhoeae...
- A multi-subunit chlamydial vaccine induces antibody and cell-mediated immunity in immunized koalas (Phascolarctos cinereus): comparison of three different adjuvantsAlison J Carey
Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, QLD, Australia
Am J Reprod Immunol 63:161-72. 2010..Little is known about the immune response in koalas, or the safety of commonly used adjuvants for induction of protective systemic and mucosal immunity...
- Willingness to offer chlamydia testing in general practice in New South WalesAsaduzzaman Khan
Department of Statistics, University of Dhaka, Bangladesh
Aust N Z J Public Health 30:226-30. 2006..To assess willingness of general practitioners (GPs) to offer chlamydia testing to patients, and to identify demographic and practice correlates associated with willingness to offer chlamydia testing...
- Describing the progression from Chlamydia trachomatis and Neisseria gonorrhoeae to pelvic inflammatory disease: systematic review of mathematical modeling studiesSereina A Herzog
Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland
Sex Transm Dis 39:628-37. 2012..A systematic review was conducted to determine how the natural history of Chlamydia trachomatis or Neisseria gonorrhoeae infection and progression to PID have been described in mathematical modeling studies...
- Risk of pelvic inflammatory disease following Chlamydia trachomatis infection: analysis of prospective studies with a multistate modelMalcolm J Price
School of Health and Population Sciences, Public Health Building, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom
Am J Epidemiol 178:484-92. 2013..Assuming a piecewise homogenous model with a higher rate during the first 60 days, corresponding results were 0.16 (95% CrI: 0.07, 0.26) and 55% (95% CrI: 32, 72), respectively. ..
- Chlamydia trachomatis infection causes mitotic spindle pole defects independently from its effects on centrosome amplificationAndrea E Knowlton
Department of Oral Biology, College of Dentistry, University of Florida, Gainesville, FL 32610, USA
Traffic 12:854-66. 2011..We hypothesize that these combined effects on mitotic spindle architecture identifies a possible mechanism for Chlamydia as a cofactor in cervical cancer formation...
- Chlamydia trachomatis infection & female infertilityAbida Malik
Department of Microbiology, Aligarh Muslim University, Aligarh, India
Indian J Med Res 123:770-5. 2006..trachomatis is increasingly being associated with long-term complications like infertility. The present study was undertaken to assess the role of C. trachomatis in female infertility as such data are lacking...
- Association of CCR5, TLR2, TLR4 and MBL genetic variations with genital tract infections and tubal factor infertilityTriin Laisk
Department of Obstetrics and Gynecology, University of Tartu, L Puusepa 8, 51014 Tartu, Estonia
J Reprod Immunol 87:74-81. 2010..Overall, these data suggest that polymorphisms in TLR4 and MBL2 play a role in receptiveness to pathogens causing genital tract infections, while MBL2 genotypes contribute to susceptibility to tubal factor infertility...
- The efficacy of clinic-based interventions aimed at increasing screening for bacterial sexually transmitted infections among men who have sex with men: a systematic reviewHuachun Zou
Sexual Health Unit, School of Population Health, University of Melbourne, Melbourne, Vic, Australia
Sex Transm Dis 39:382-7. 2012..We undertook a systematic review to identify clinic-based strategies for increasing screening and detection of bacterial STIs among MSM...
- Population-based outreach for Chlamydia screening in men: results from a randomized trialDelia Scholes
Center for Health Studies, Group Health Cooperative, Seattle, WA 98101, USA
Sex Transm Dis 34:837-9. 2007..To evaluate the feasibility and efficacy of population-based outreach strategies to improve genital Chlamydia trachomatis (CT) screening in men...
- Interaction of microbiology and pathology in women undergoing investigations for infertilityJoseph Debattista
Sexual Health and AIDS Service, Prince Charles Hospital, Health Service District, Brisbane, Australia
Infect Dis Obstet Gynecol 12:135-45. 2004....
- Caspase-1 dependent IL-1β secretion is critical for host defense in a mouse model of Chlamydia pneumoniae lung infectionKenichi Shimada
Division of Pediatrics Infectious Disease and Immunology, Cedars Sinai Medical Center and David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California, United States of America
PLoS ONE 6:e21477. 2011..Interestingly, Caspase-1 activation during CP infection occurs with mitochondrial dysfunction indicating a possible mechanism involving the mitochondria for CP-induced inflammasome activation...
- CXCR3 and CCR5 are both required for T cell-mediated protection against C. trachomatis infection in the murine genital mucosaA J Olive
Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts, USA
Mucosal Immunol 4:208-16. 2011..These results show that CXCR3 and CCR5 are the predominant chemokine receptors that act cooperatively to promote homing to the genital mucosa during Chlamydia infection...
- Multi locus sequence typing of Chlamydiales: clonal groupings within the obligate intracellular bacteria Chlamydia trachomatisYvonne Pannekoek
Department of Medical Microbiology, Center for Infection and Immunity Amsterdam CINIMA, Academic Medical Center, Amsterdam, The Netherlands
BMC Microbiol 8:42. 2008..We developed a multi locus sequence typing (MLST) scheme to understand the population genetic structure and diversity of these species and to evaluate the association between genotype and disease...
- Population prevalence of Chlamydia trachomatis and Neisseria gonorrhoeae in the Netherlands. Should asymptomatic persons be tested during population-based Chlamydia screening also for gonorrhoea or only if chlamydial infection is found?Jan E A M van Bergen
STI AIDS Netherlands Soa Aids Nederland, Amsterdam, The Netherlands
BMC Infect Dis 6:42. 2006..Screening and active case finding for Chlamydia trachomatis (CT) is recommended to prevent reproductive morbidity. However insight in community prevalence of gonococcal infections and co-infections with Neisseria gonorrhoea (NG) is lacking...
- Contact tracing to control infectious disease: when enough is enoughBenjamin Armbruster
Department of Management Science and Engineering, Stanford University, Stanford, CA 94305 4026, USA
Health Care Manag Sci 10:341-55. 2007..We present an example application to contact tracing for chlamydia control...
- Detection of Chlamydia trachomatis and Neisseria gonorrhoeae by enzyme immunoassay, culture, and three nucleic acid amplification testsE Van Dyck
STD HIV Research and Intervention Unit, Department of Microbiology, Institute of Tropical Medicine, Nationalestraat 155, B 2000 Antwerp, Belgium
J Clin Microbiol 39:1751-6. 2001..trachomatis EIA. The accuracies of the different NAATs were quite similar. SDA was the only amplification assay with 100% specificity for detection of both N. gonorrhoeae and C. trachomatis in endocervical specimens...
- Neonatal chlamydial pneumonia induces altered respiratory structure and function lasting into adult lifeMadhulika Jupelli
Department of Biology, South Texas Center for Emerging Infectious Disease, University of Texas at San Antonio, San Antonio, TX 78249, USA
Lab Invest 91:1530-9. 2011..The results of our studies also emphasize the importance of prenatal screening and treatment of pregnant women for C. trachomatis in order to prevent the infection of neonates...
- Genotyping of Chlamydia trachomatis from clinical specimens in TaiwanMin Chih Hsu
Laboratory for Bacteriology and Mycology, Center for Laboratory Research and Diagnostics, Center for Disease Control, Taipei, Taiwan
J Med Microbiol 55:301-8. 2006..018) between northern and southern Taiwan. Sequence mutation analysis by blast searching against GenBank reference sequences identified 12 genetic variants from a total of 102 omp1 gene sequences...
- Fitz-Hugh-Curtis syndrome. Radiologic manifestationAkihiro Nishie
Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
J Comput Assist Tomogr 27:786-91. 2003..To clarify radiologic findings of Fitz-Hugh-Curtis syndrome (FHCS)...
- Characterisation of Chlamydia trachomatis by ompA sequencing and multilocus sequence typing in a Swedish county before and after identification of the new variantMargaretha Jurstrand
Clinical Research Centre, Orebro University Hospital, Orebro SE 70185, Sweden
Sex Transm Infect 86:56-60. 2010..The study also aimed to evaluate the discriminatory capacity of multilocus sequence typing (MLST) compared with ompA sequencing...
- Predicting the population impact of chlamydia screening programmes: comparative mathematical modelling studyM Kretzschmar
Julius Centre for Health Sciences and Primary Care, University Medical Centre Utrecht, Utrecht, The Netherlands
Sex Transm Infect 85:359-66. 2009..The objective of this study was to conduct a direct comparison of the effect of organised chlamydia screening in different models...
- Prevalence of Mycoplasma genitalium among female students in vocational schools in JapanR Hamasuna
Division of Urology, Department of Surgery, Faculty of Medicine, University of Miyazaki, Kiyotake, Miyazaki 889 1692, Japan
Sex Transm Infect 84:303-5. 2008..The objective of this study was to determine the prevalence of M genitalium infection among younger females and to determine risk factors for this infection...
- Untreated gonococcal and chlamydial infection in a probability sample of adultsCharles F Turner
Program in Health and Behavior Measurement, Research Triangle Institute, 1615 M St NW, Washington, DC 20036, USA
JAMA 287:726-33. 2002..Development of nucleic acid amplification tests, such as the ligase chain reaction assay, provides new opportunities to estimate the prevalence of untreated infections in the population...
- Chlamydia muridarum infection subverts dendritic cell function to promote Th2 immunity and airways hyperreactivityGerard E Kaiko
School of Biomedical Sciences and The Asthma and Respiratory Diseases Priority Research Centre, University of Newcastle and Hunter Medical Research Institute, Newcastle, Australia
J Immunol 180:2225-32. 2008..In the setting of allergic airways inflammation, this infection may then contribute to exacerbation of the asthmatic phenotype...
- Neonatal chlamydial infection induces mixed T-cell responses that drive allergic airway diseaseJay C Horvat
Priority Research Centre for Asthma and Respiratory Disease, School of Biomedical Sciences, Faculty of Health, University of Newcastle, Newcastle, Australia
Am J Respir Crit Care Med 176:556-64. 2007..Chlamydial lung infection has been associated with asthma in children and adults. However, how chlamydial infection influences the development of immune responses that promote asthma remains unknown...
- Chaperone Mining of the Chlamydia Type Three Secretion SystemELLENA MARIE PETERSON; Fiscal Year: 2010..in host cells is fundamental to our efforts to design effective therapies that can aid in the prevention of Chlamydia infections. It has recently been shown that Chlamydia possesses genes for a type three secretion (TTS) system...
- A Point of Care, Nucleic Acid Test for Chlamydia to Ensure Prompt Treatment of HeLAURA T MAZZOLA; Fiscal Year: 2013..test into a community clinic testing program, toward the goal of increasing early identification of chlamydia infections in populations that are disproportionately affected...
- High throughput proteomics to dissect Chlamydia-host cell interactionsJoanne N Engel; Fiscal Year: 2013..will yield important clues into the pathogenesis of Chlamydia respiratory infections, the role of Chlamydia infections in atherosclerotic heart disease, and the role of Chlamydia infections in lung cancer...
- Mechanism of Chlamydia-induced centrosome amplificationMing Tan; Fiscal Year: 2010b>Chlamydia infections are the most commonly reported infectious disease in the U.S...
- Immunomodulation and Vaccine Optimization against ChlamydiaQing He; Fiscal Year: 2013..In the United States 1,108,374 Chlamydia infections were reported to the Centers for Disease Prevention and Control in 2007...
- Regulation of Virulence Gene Expression in ChlamydiaP Scott Hefty; Fiscal Year: 2013..will allow in the future for rationale design of novel molecules that interrupt the function of ChxR and Chlamydia infections. PUBLIC HEALTH RELEVANCE: Proposed studies will facilitate our understanding of how and what controls the ..
- Immunoregulatory Networks in Chlamydia Genital Tract InfectionAmy M Scurlock; Fiscal Year: 2013..devastating reproductive complications, such as infertility and ectopic pregnancy, associated with Chlamydia infections. The research plan will evaluate the expanding diversity of effector and regulatory CD4+ T-cell responses ..
- Can Chlamydial Infection Increase Host Mutation Frequency?ROBERT SCHOBORG; Fiscal Year: 2009..This proposal will begin to evaluate the possibility that chlamydia infections may damage host cell DNA, leading to mutations and, possibly, to cancer...
- Combination Antibotics as a Treatment for Chlamydia-Induced Reactive ArthritisJohn Carter; Fiscal Year: 2007..This project will be a critical pathway in discovering a cure for persistent Chlamydia infections in the joint and at other anatomic sites...
- Functional Genomic Analysis of the Chlamydia InclusionRAPHAEL VALDIVIA; Fiscal Year: 2005..We will raise antibodies to these Chlamydia proteins to determine their subcellular localization during Chlamydia infections. In the last stage of the screen, we will use the antibodies and cell lines generated to determine if these ..
- Single Cell Expression Profiling of Chlamydia GenesMICHAEL STARNBACH; Fiscal Year: 2004..expression in these organisms during their developmental cycle because of the difficulty in synchronizing Chlamydia infections. The use of FISH technology circumvents the problem of asynchronous infections because we will be able to ..
- MID AMERICA ADOLESCENT STD COOPERATIVE RESEARCH CENTERDonald Orr; Fiscal Year: 2003..The other will examine the relationships of omp1 genotype, immune factors and repeated lower genital tract chlamydia infections in adolescent women...
- HIV Risk-reduction with Drug-using YouthDaniel Pilowsky; Fiscal Year: 2005..use; and (4) To gather descriptive epidemiological data on the prevalence and incidence of gonorrheal and Chlamydia infections among the index NIDUs enrolled in the clinical trial...
- Immune Responses in Genital Chlamydia Prior to TherapyWILLIAM GEISLER; Fiscal Year: 2005..abstract_text> ..
- Host response to Chlamydia genital infection in the maleRoger Rank; Fiscal Year: 2008..abstract_text> ..
- Potential for HIV transmission in relationships of drug-using women in RussiaLinda Niccolai; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- BLOCKING INFECTIOUS ENTRY OF STD PATHOGENSRichard Cone; Fiscal Year: 2003..lines, to determine whether monoclonals that have been taken up by epithelial cells are effective for blocking HIV, HSV-2, and chlamydia infections, and for blocking adhesions and transepithelial migration of leukocytes.
- Host Factors in Susceptibility to Chlamydial DiseaseKYLE RAMSEY; Fiscal Year: 2006....
- LOCAL IMMUNE RESPONSE IN CHLAMYDIA SALPINGITISDorothy Patton; Fiscal Year: 2003..trachomatis- induced PID. If one chlamydial antigen is the major cause of the DTH response in PID, diagnostic or immunomodulatory efforts can be directed towards that antigen. ..
- Improved Macaque Safety Model for Topical Microbicides: Post-coital AssessmentsDorothy Patton; Fiscal Year: 2008..In addition, we will collect parallel assessments, when mating has occurred with a placebo gel (HEC universal placebo) in place. These studies will provide urgently needed data regarding topical microbicide use with coital activity. ..
- The Acquisition of Bacterial Vaginosis in LesbiansJeanne Marrazzo; Fiscal Year: 2006..Lesbian couples provide a unique opportunity to conduct comparative studies of vaginal microbial ecology in sex partners, and to directly analyze determinants of transmission. ..
- Inflammation and Ovarian CancerClareann Bunker; Fiscal Year: 2008..In particular, NSAID use may prove to be a potentially important chemopreventative for this often-fatal disease. ..
- Spatial Epidemiology of Syphilis and Gonorrhea in North CarolinaWilliam C Miller; Fiscal Year: 2010..Furthermore, we will obtain critical, new information regarding STI epidemiology in southeastern U.S., a region with disproportionate burden of these infections. ..
- CELLULAR TRAFFICKING TO INFLAMED FEMALE GENITAL MUCOSAKathleen Kelly; Fiscal Year: 2007..Insight into CXCL13 secretion will impact public health and the welfare of women in the US by aiding the development of therapeutics to prevent tubal infertility. ..
- Chlamydia trachomatis, Genital Flora, & STD PathogenesisGerald Byrne; Fiscal Year: 2004..This hypothesis will be tested by determining the effects of indole-producing normal flora on chlamydial genital tract disease in a well-characterized murine model. ..
- A community-level RCT of expedited partner treatment for gonorrhea and chlamydiaMatthew R Golden; Fiscal Year: 2010..abstract_text> ..
- Prevention of Infertility in Women With Subclinical PIDHAROLD WIESENFELD; Fiscal Year: 2007..During this study, very real public health questions will be asked and answered which will affect the way that lower genital tract infections are routinely managed, potentially enhancing fertility among American women. ..
- Oral Contraceptive Use and Bone Density in Young WomenDelia Scholes; Fiscal Year: 2008..abstract_text> ..
- Urinary Symptoms in Adolescent Females: STI or UTI?Jill Huppert; Fiscal Year: 2004..The findings of this study will strengthen the evidence base for symptom-based STI testing of SA adolescent females and will promote care that addresses both individual patient and public health needs. ..
- C. trachomatis genomics, strain typing, and evolutionDeborah Dean; Fiscal Year: 2008..unreadable] [unreadable]..
- Pathogenesis of Persistent Chlamydial STDsDeborah Dean; Fiscal Year: 2007..1 Description, ..
- PATHOGENIC MECHANISMS IN UTIWalter Stamm; Fiscal Year: 2007..Face Page .................................................................................................. 1 B. Description, ..
- Prophylactic Ibuprofen: Effect on IUD Continuation RatesDavid Hubacher; Fiscal Year: 2003..In the US, ibuprofen may help spur renewed interest in the most cost effective and efficacious reversible contraceptive method available. ..
- Immunobiology of ChlamydiaRaymond Johnson; Fiscal Year: 2004..T cell culture system that he developed during prior training to study the mucosal immune response to chlamydia infections of the reproductive tract...
- PATHOGENESIS OF CHLAMYDIAL OCULAR INFECTIONSDeborah Dean; Fiscal Year: 2004..A greater understanding of the pathogenesis of trachoma will aid in developing public health interventions and a vaccine that can be implemented in trachoma endemic areas throughout the world. ..
- Exacerbation of AtherosclerosisGuangming Zhong; Fiscal Year: 2004..pneumoniae exacerbation of atherosclerosis will be evaluated. These studies may provide the essential information on designing effective approaches for preventing and controlling C. pneumoniae-exacerbated atherosclerosis. ..
- Cellular Immunity to Chlamydua at the Epithelial InterfaceRAYMOND MORRIS JOHNSON; Fiscal Year: 2010..Defining what protective T cells look like, and how they function, will be critical for designing and assessing future Chlamydia candidate vaccines. ..
- Chlamydial Manipulation of Host ApoptosisGuangming Zhong; Fiscal Year: 2010..abstract_text> ..
- Ectopic Pregnancy: Assessing Long-Term Trends in Rates and Risk FactorsDelia Scholes; Fiscal Year: 2008..unreadable] [unreadable] [unreadable] [unreadable]..
- MEASURING HIV RISK IN A CLINIC POPULATIONSusan Rogers; Fiscal Year: 2001..They will use the new sperm assay plus urine-based assays for gonorrhea and chlamydial infection to validate measures of recent unprotected intercourse. ..
- Chlamydia-infected Epithelial Cell Secretion of Immunoregulatory CytokinesWILBERT DERBIGNY; Fiscal Year: 2008..unreadable] DESCRIPTION (provided by applicant): NO ABSTRACT WAS PROVIDED BY THE PI. [unreadable] [unreadable] [unreadable] [unreadable]..
- Monitoring STI's in the PopulationSusan Rogers; Fiscal Year: 2009..This research takes the next step toward this goal - moving from studying the prevalence of untreated infections to tracking changes over time in the prevalence, distribution, and correlates of these untreated infections. ..
- VIRULENCE FACTORS OF CHLAMYDIAEPRISCILLA WYRICK; Fiscal Year: 2009....
- AFFECT AND MARIJUANA USE IN ADOLESCENTS AND YOUNG ADULTSLydia Shrier; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Therapy and Prevention for Bacterial VaginosisJane Schwebke; Fiscal Year: 2006..We will also utilize specimens from these prospective studies to further study the association of Mobiluncus, an organism strongly associated with BV using sensitive PCR technology. ..
- STD Screening in Young Women: A Stage-based InterventionMARIAM CHACKO; Fiscal Year: 2003..Secondary outcomes will include progression through the Stages of Change for STH screening, the frequency of consistent condom use during the past 30 days and number of episodes of gonococcal or chlamydial infections over 12 months. ..
- MENTAL HEALTH AND BEHAVIOR IN ADOLESCENT STD PREVENTIONLydia Shrier; Fiscal Year: 2003....
- Concordance Rates of Mobiluncus Among Sexual PartnersJane Schwebke; Fiscal Year: 2004..Our hypothesis is that Mobiluncus curtisii is important in the pathogenesis of BV and high concordance rates among sexual partners will be found suggesting sexual transmission. ..
- REDUCING HIV RISK IN FEMALE TEENS: A TAILORED APPROACHRalph DiClemente; Fiscal Year: 2004..abstract_text> ..
- Transmissibility of GC and Ct Diagnosed using NAATSusan Rogers; Fiscal Year: 2004....
- ATTENDED CITY SCHOOLYARDS TO INCREASE PHYSICAL ACTIVITYThomas Farley; Fiscal Year: 2004....
- Validating Sexual Behavior by Y-chromosome PCRJonathan Zenilman; Fiscal Year: 2005..Since Yc sampling requires only a vaginal swab, and is stable under field conditions, this test promises to be a practical and easily used biomarker for sexual behavior research. ..
- Teens and Exposure to HIV Risk on the WebRalph DiClemente; Fiscal Year: 2005..Given the controversy surrounding teens' exposure to sexual content on the Web, there is a compelling need to examine the impact of these exposures on teens' sexual health. ..
- Recovery of Vaginal Flora after Douching CessationJonathan Zenilman; Fiscal Year: 2006..Data from this research will begin to describe the natural history of BV and aid in the design of behavioral interventions for vaginal douching. [unreadable] [unreadable]..
- Reiter's syndrome mechanism of chlamydial pathogenesisAlan Hudson; Fiscal Year: 2008....
- Tinidazole for the Treatment of Bacterial VaginosisJane Schwebke; Fiscal Year: 2007..In addition, we will measure vaginal and serum concentrations of drug during treatment and correlate with cure rates, short-term recurrence of BV, and severity of infection. ..
- Role of Chlamydia Pneumoniae in AtherosclerosisCho Chou Kuo; Fiscal Year: 2007..pneumoniae infection and reduction of atherosclerosis and coronary heart disease. ..
- CLINICAL RESEARCH IN STDSJonathan Zenilman; Fiscal Year: 2007..Mentees at all levels are expected to develop an independent research project resulting in presentation at national meetings and publication. ..
- Control of Trichomoniasis -A Paradigm for STD ControlJane Schwebke; Fiscal Year: 2006..vaginalis, to examine strain differences using PFGE, and to examine the prevalence of resistance strains and their potential contribution to treatment failure. ..
- Mood and HIV Risk in Depressed AdolescentsLydia Shrier; Fiscal Year: 2006..Enhancing our understanding of the associations of mood and risk behavior among depressed adolescents will be essential to the development ns designed specifically for this at-risk population. ..
- CHLAMYDIA PNEUMONIAE--A PATHOGEN IN ALZHEIMERS DISEASEAlan Hudson; Fiscal Year: 2002..Such new information may well provide important new insights for development of novel therapeutic modalities to prevent or ameliorate late-onset AD. ..
- HOMELESS YOUTH: STREET CULTURE/SOCIAL NETWORKS/HIV-RISKColette Auerswald; Fiscal Year: 2005..An understanding of how social network connections promote and prevent risky behaviors would also have significant implications for the designing of interventions with this population. ..
- HIV Risk Among Homeless MothersCAROL CATON; Fiscal Year: 2007..The study will inform the design of HIV risk behavior preventive interventions appropriate to the life circumstances of homeless mothers. ..