chlamydia infections

Summary

Summary: Infections with bacteria of the genus CHLAMYDIA.

Top Publications

  1. pmc Chlamydial persistence: beyond the biphasic paradigm
    Richard J Hogan
    Infectious Diseases Program and Cooperative Research Centre for Diagnostics, School of Life Sciences, Queensland University of Technology, Brisbane, Australia
    Infect Immun 72:1843-55. 2004
  2. pmc Whole-genome analysis of diverse Chlamydia trachomatis strains identifies phylogenetic relationships masked by current clinical typing
    Simon R Harris
    Pathogen Genomics, The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK
    Nat Genet 44:413-9, S1. 2012
  3. pmc Chlamydia trachomatis persistence in vitro: an overview
    Priscilla B Wyrick
    Department of Microbiology, J H Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA
    J Infect Dis 201:S88-95. 2010
  4. pmc Effectiveness of yearly, register based screening for chlamydia in the Netherlands: controlled trial with randomised stepped wedge implementation
    Ingrid V F van den Broek
    Unit of Epidemiology and Surveillance, RIVM Centre for Infectious Disease Control Netherlands, PO Box 1, 3720 BA Bilthoven, Netherlands
    BMJ 345:e4316. 2012
  5. ncbi Risk of sequelae after Chlamydia trachomatis genital infection in women
    Catherine L Haggerty
    Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    J Infect Dis 201:S134-55. 2010
  6. ncbi Histopathologic changes related to fibrotic oviduct occlusion after genital tract infection of mice with Chlamydia muridarum
    Anita A Shah
    Department of Microbiology, Chicago College of Osteopathic Medicine, Midwestern University, 555 31st Street, Downers Grove, IL 60515, USA
    Sex Transm Dis 32:49-56. 2005
  7. ncbi Prevalence of Chlamydia trachomatis: results from the first national population-based survey in France
    V Goulet
    Institut de Veille Sanitaire, 12 Rue du Val d Osne, Saint Maurice 94410, France
    Sex Transm Infect 86:263-70. 2010
  8. ncbi Sexual behaviour in Britain: reported sexually transmitted infections and prevalent genital Chlamydia trachomatis infection
    K A Fenton
    Centre for Infectious Disease Epidemiology, Department of Primary Care, Royal Free and University College London Medical School, London, UK
    Lancet 358:1851-4. 2001
  9. ncbi The cellular paradigm of chlamydial pathogenesis
    Richard S Stephens
    Division of Infectious Diseases, School of Public Health, 140 Earl Warren Hall, University of California, Berkeley 94720, USA
    Trends Microbiol 11:44-51. 2003
  10. pmc Mechanisms of host cell exit by the intracellular bacterium Chlamydia
    Kevin Hybiske
    Division of Infectious Diseases, School of Public Health, University of California, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 104:11430-5. 2007

Detail Information

Publications286 found, 100 shown here

  1. pmc Chlamydial persistence: beyond the biphasic paradigm
    Richard J Hogan
    Infectious Diseases Program and Cooperative Research Centre for Diagnostics, School of Life Sciences, Queensland University of Technology, Brisbane, Australia
    Infect Immun 72:1843-55. 2004
  2. pmc Whole-genome analysis of diverse Chlamydia trachomatis strains identifies phylogenetic relationships masked by current clinical typing
    Simon R Harris
    Pathogen Genomics, The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK
    Nat Genet 44:413-9, S1. 2012
    ..We used our phylogenetic framework to show how genetic exchange has manifested itself in ocular, urogenital and LGV C. trachomatis strains, including the epidemic LGV serotype L2b...
  3. pmc Chlamydia trachomatis persistence in vitro: an overview
    Priscilla B Wyrick
    Department of Microbiology, J H Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA
    J Infect Dis 201:S88-95. 2010
    ....
  4. pmc Effectiveness of yearly, register based screening for chlamydia in the Netherlands: controlled trial with randomised stepped wedge implementation
    Ingrid V F van den Broek
    Unit of Epidemiology and Surveillance, RIVM Centre for Infectious Disease Control Netherlands, PO Box 1, 3720 BA Bilthoven, Netherlands
    BMJ 345:e4316. 2012
    ..To evaluate the effectiveness of register based, yearly chlamydia screening...
  5. ncbi Risk of sequelae after Chlamydia trachomatis genital infection in women
    Catherine L Haggerty
    Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    J Infect Dis 201:S134-55. 2010
    ..trachomatis infection; better tools to measure PID and tubal damage; and studies on the natural history of repeated chlamydial infections are needed...
  6. ncbi Histopathologic changes related to fibrotic oviduct occlusion after genital tract infection of mice with Chlamydia muridarum
    Anita A Shah
    Department of Microbiology, Chicago College of Osteopathic Medicine, Midwestern University, 555 31st Street, Downers Grove, IL 60515, USA
    Sex Transm Dis 32:49-56. 2005
    ..We sought to determine if intraluminal occluding fibrosis of the oviduct occurs after urogenital Chlamydia muridarum infection in mice...
  7. ncbi Prevalence of Chlamydia trachomatis: results from the first national population-based survey in France
    V Goulet
    Institut de Veille Sanitaire, 12 Rue du Val d Osne, Saint Maurice 94410, France
    Sex Transm Infect 86:263-70. 2010
    ..Few studies have estimated Chlamydia trachomatis (CT) prevalence in the general population, most prevalence studies being based on people already attending healthcare settings...
  8. ncbi Sexual behaviour in Britain: reported sexually transmitted infections and prevalent genital Chlamydia trachomatis infection
    K A Fenton
    Centre for Infectious Disease Epidemiology, Department of Primary Care, Royal Free and University College London Medical School, London, UK
    Lancet 358:1851-4. 2001
    ..The results have potentially wide application for proposed chlamydia screening programmes which, given the demonstrated prevalence, must now proactively seek to involve men...
  9. ncbi The cellular paradigm of chlamydial pathogenesis
    Richard S Stephens
    Division of Infectious Diseases, School of Public Health, 140 Earl Warren Hall, University of California, Berkeley 94720, USA
    Trends Microbiol 11:44-51. 2003
    ....
  10. pmc Mechanisms of host cell exit by the intracellular bacterium Chlamydia
    Kevin Hybiske
    Division of Infectious Diseases, School of Public Health, University of California, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 104:11430-5. 2007
    ..The participation of Rho was unique in that it functioned late in extrusion. The dual nature of release characterized for Chlamydia has not been observed as a strategy for intracellular bacteria...
  11. pmc Secretion of proinflammatory cytokines by epithelial cells in response to Chlamydia infection suggests a central role for epithelial cells in chlamydial pathogenesis
    S J Rasmussen
    Francis I Proctor Foundation, University of California, San Francisco 94143, USA
    J Clin Invest 99:77-87. 1997
    ..These findings suggest a novel pathophysiologic concept wherein the acute host response to Chlamydia at mucosal surfaces is primarily initiated and sustained by epithelial cells, the first and major targets of chlamydial infection...
  12. pmc Transmission of Chlamydia trachomatis through sexual partnerships: a comparison between three individual-based models and empirical data
    Christian L Althaus
    Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland
    J R Soc Interface 9:136-46. 2012
    ..We suggest that the Gini coefficient is a useful measure for calibrating infectious disease models that include risk structure and highlight the need to estimate this measure for other STIs...
  13. pmc The role of reinfection and partner notification in the efficacy of Chlamydia screening programs
    Janneke C M Heijne
    Division of Clinical Epidemiology and Biostatistics, Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland
    J Infect Dis 203:372-7. 2011
    ..Effective management of sex partners to prevent reinfection might need to be strengthened in chlamydia control programs...
  14. ncbi Typing Chlamydia trachomatis: from egg yolk to nanotechnology
    Lisbeth Nørum Pedersen
    Department of Clinical Microbiology, Aarhus University Hospital, Skejby, Denmark
    FEMS Immunol Med Microbiol 55:120-30. 2009
    ..However, it is important to realize that culture of C. trachomatis may still be needed to detect and characterize new variants of C. trachomatis...
  15. pmc Tumor necrosis factor alpha production from CD8+ T cells mediates oviduct pathological sequelae following primary genital Chlamydia muridarum infection
    Ashlesh K Murthy
    South Texas Center for Emerging Infectious Diseases, Department of Biology, University of Texas at San Antonio, San Antonio, Texas 78249, USA
    Infect Immun 79:2928-35. 2011
    ..These results provide compelling new evidence supporting the contribution of CD8(+) T cells and TNF-α production to Chlamydia-induced reproductive tract sequelae...
  16. ncbi Duration of untreated, uncomplicated Chlamydia trachomatis genital infection and factors associated with chlamydia resolution: a review of human studies
    William M Geisler
    Department of Medicine, Division of Infectious Diseases, University of Alabama at Birmingham, Birmingham, AL 35294 0007, USA
    J Infect Dis 201:S104-13. 2010
    ..This article summarizes the key questions posed and the evidence reviewed on the duration of untreated, uncomplicated genital chlamydial infection in humans and the factors associated with chlamydia resolution...
  17. pmc Pathogenesis of genital tract disease due to Chlamydia trachomatis
    Toni Darville
    Departments of Pediatrics and Immunology, University of Pittsburgh Medical Cente, USA
    J Infect Dis 201:S114-25. 2010
    ....
  18. ncbi The natural history of untreated Chlamydia trachomatis infection in the interval between screening and returning for treatment
    William M Geisler
    Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294 0007, USA
    Sex Transm Dis 35:119-23. 2008
    ..An improved understanding of chlamydial natural history may influence recommendations for elements of control efforts such as chlamydia screening frequency or time parameters for partner notification...
  19. pmc Expression of matrix metalloproteinases subsequent to urogenital Chlamydia muridarum infection of mice
    K H Ramsey
    Department of Microbiology and Immunology, Chicago College of Osteopathic Medicine, Midwestern University, IL 60516, USA
    Infect Immun 73:6962-73. 2005
    ..These differences may account for disparate outcomes with regard to chronic sequelae of the disease...
  20. ncbi Using quantitative polymerase chain reaction to correlate Chlamydia pecorum infectious load with ocular, urinary and reproductive tract disease in the koala (Phascolarctos cinereus)
    C Wan
    Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, Brisbane, Australia
    Aust Vet J 89:409-12. 2011
    ..These results suggest a complex disease pathogenesis and clinical course in C. pecorum-infected koalas...
  21. ncbi Chlamydia trachomatis trends in the United States among persons 14 to 39 years of age, 1999-2008
    S Deblina Datta
    National Center for HIV AIDS, Viral Hepatitis, STD and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA
    Sex Transm Dis 39:92-6. 2012
    ..We report the first population-based assessment of national trends in chlamydia prevalence in the United States...
  22. pmc The hypothetical protein CT813 is localized in the Chlamydia trachomatis inclusion membrane and is immunogenic in women urogenitally infected with C. trachomatis
    Chaoqun Chen
    Department of Microbiology and Immunology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, Texas 78229, USA
    Infect Immun 74:4826-40. 2006
    ..Thus, the CT813 protein may represent an important candidate for understanding C. trachomatis pathogenesis and developing intervention and prevention strategies for controlling C. trachomatis infection...
  23. pmc Interleukin-13 promotes susceptibility to chlamydial infection of the respiratory and genital tracts
    Kelly L Asquith
    Centre for Asthma and Respiratory Disease and Hunter Medical Research Institute, University of Newcastle, Newcastle, Australia
    PLoS Pathog 7:e1001339. 2011
    ..Collectively our findings demonstrate that innate IL-13 release promotes infection that results in enhanced inflammation and have broad implications for the treatment of chlamydial infections and IL-13-associated diseases...
  24. pmc Chlamydia trachomatis genital tract infection of antibody-deficient gene knockout mice
    H Su
    Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA
    Infect Immun 65:1993-9. 1997
    ..Therefore, these data suggest that both humoral and cell-mediated immune responses were important mediators of immune protection in this model, though cell-mediated immune responses appear to play a more dominant role...
  25. ncbi Epidemiology of Chlamydia trachomatis infection in women and the cost-effectiveness of screening
    J A Land
    Department of Obstetrics and Gynaecology, University Medical Center Groningen, Groningen, The Netherlands
    Hum Reprod Update 16:189-204. 2010
    ..There is considerable debate over the exact complication rates after chlamydia infections, and more precise estimates of PID and tubal infertility are needed, for instance to be inserted in ..
  26. ncbi Evidence for long-term cervical persistence of Chlamydia trachomatis by omp1 genotyping
    D Dean
    Children s Hospital Oakland Research Institute, Oakland, CA 94609, USA
    J Infect Dis 182:909-16. 2000
    ..These data demonstrate that cervical infections with C class serovars can persist for years and may have specific biologic properties that allow for modulation of the major outer membrane protein in response to immune selection...
  27. ncbi Toll-like receptor-2, but not Toll-like receptor-4, is essential for development of oviduct pathology in chlamydial genital tract infection
    Toni Darville
    Division of Pediatric Infectious Diseases, Arkansas Children s Hospital and University of Arkansas for Medical Sciences, Little Rock, AR 72202, USA
    J Immunol 171:6187-97. 2003
    ..TLR2 is an important mediator in the innate immune response to C. trachomatis infection and appears to play a role in both early production of inflammatory mediators and development of chronic inflammatory pathology...
  28. ncbi Prevalence of chlamydial and gonococcal infections among young adults in the United States
    William C Miller
    Department of Medicine, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill 27599 7435, USA
    JAMA 291:2229-36. 2004
    ..Although screening for Chlamydia trachomatis is widely recommended among young adult women, little information is available regarding the prevalence of chlamydial and gonococcal infections in the general young adult population...
  29. ncbi Genital Chlamydia trachomatis infections
    C Bebear
    Laboratoire de Bactériologie EA 3671, Infections Humaines à Mycoplasmes et Chlamydiae, CNR des Infections à Chlamydiae, Universite Victor Segalen Bordeaux 2, Bordeaux, France
    Clin Microbiol Infect 15:4-10. 2009
    ..Single-dose therapy has been a significant development for treatment of an uncomplicated infection of the patient and his or her sexual partner...
  30. pmc Specific chlamydial inclusion membrane proteins associate with active Src family kinases in microdomains that interact with the host microtubule network
    Jeffrey Mital
    Host Parasite Interactions Section, Laboratory of Intracellular Parasites, National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratories, NIAID, NIH, Hamilton, MT 59840, USA
    Cell Microbiol 12:1235-49. 2010
    ..Together, the data suggest that a specific structure on the C. trachomatis inclusion membrane may be responsible for the known interactions of chlamydiae with the microtubule network and resultant effects on centrosome stability...
  31. pmc Randomised controlled trial of screening for Chlamydia trachomatis to prevent pelvic inflammatory disease: the POPI (prevention of pelvic infection) trial
    Pippa Oakeshott
    Division of Community Health Sciences, St George s, University of London SW17 0RE
    BMJ 340:c1642. 2010
    ..To determine whether screening and treating women for chlamydial infection reduces the incidence of pelvic inflammatory disease over the subsequent 12 months...
  32. pmc Caspase-1 contributes to Chlamydia trachomatis-induced upper urogenital tract inflammatory pathologies without affecting the course of infection
    Wen Cheng
    Department of Microbiology and Immunology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    Infect Immun 76:515-22. 2008
    ....
  33. ncbi Animal chlamydioses and zoonotic implications
    D Longbottom
    Moredun Research Institute, Pentlands Science Park, Bush Loan, Penicuik, Midlothian EH26 0PZ, UK
    J Comp Pathol 128:217-44. 2003
  34. pmc Chlamydia trachomatis in the United Kingdom: a systematic review and analysis of prevalence studies
    E J Adams
    Statistics, Modelling and Economics Department, Communicable Disease Surveillance Centre, Health Protection Agency, 61 Colindale Avenue, London NW9 5EQ, UK
    Sex Transm Infect 80:354-62. 2004
    ....
  35. ncbi Rectal gonorrhea and chlamydia reinfection is associated with increased risk of HIV seroconversion
    Kyle T Bernstein
    Epidemiology, Research and Surveillance, STD Prevention and Control Services, San Francisco Department of Public Health, San Francisco, CA 94103, USA
    J Acquir Immune Defic Syndr 53:537-43. 2010
    ..HIV infection continues to disproportionately affect men who have sex with men (MSM). Identification of modifiable risk factors for HIV infection among MSM is critical for effective prevention...
  36. pmc Efficacy of interventions to increase the uptake of chlamydia screening in primary care: a systematic review
    Rebecca J Guy
    The Kirby Institute, Sydney, New South Wales, Australia
    BMC Infect Dis 11:211. 2011
    As most genital chlamydia infections are asymptomatic, screening is the main way to detect and cases for treatment...
  37. pmc Using educational outreach and a financial incentive to increase general practices' contribution to chlamydia screening in South-East London 2003-2011
    Sebastian Kalwij
    Amersham Vale Practice, Waldron Health Centre, London SE14 6LD, United Kingdom
    BMC Public Health 12:802. 2012
    ....
  38. pmc Knowledge of Chlamydia trachomatis among men and women approached to participate in community-based screening, Scotland, UK
    Karen Lorimer
    Institute for Applied Health Research, Glasgow Caledonian University, Glasgow, UK
    BMC Public Health 10:794. 2010
    ..This study aimed to determine the level of awareness and knowledge of chlamydia among young people who were being approached in a variety of community settings and offered opportunistic screening...
  39. pmc Trends in chlamydia and gonorrhea positivity among heterosexual men and men who have sex with men attending a large urban sexual health service in Australia, 2002-2009
    Lenka A Vodstrcil
    Melbourne School of Population Health, The University of Melbourne, Vic, Australia
    BMC Infect Dis 11:158. 2011
    ..To determine whether chlamydia positivity among heterosexual men (MSW) and chlamydia and gonorrhea positivity among men who have sex with men (MSM), are changing...
  40. ncbi Chlamydia infection, pelvic inflammatory disease, ectopic pregnancy and infertility: cross-national study
    Nicole Bender
    Institute of Social and Preventive Medicine, University of Bern, Bern CH 3012, Switzerland
    Sex Transm Infect 87:601-8. 2011
    ....
  41. pmc Immunity to murine chlamydial genital infection
    Richard P Morrison
    Department of Microbiology, Montana State University, Bozeman 59717, USA
    Infect Immun 70:2741-51. 2002
  42. pmc Generation of targeted Chlamydia trachomatis null mutants
    Laszlo Kari
    Laboratory of Intracellular Parasites, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    Proc Natl Acad Sci U S A 108:7189-93. 2011
    ..Additionally, this strategy could be applied to other medically important bacterial pathogens with no or difficult genetic systems...
  43. pmc Coverage and uptake of systematic postal screening for genital Chlamydia trachomatis and prevalence of infection in the United Kingdom general population: cross sectional study
    John Macleod
    Department of Primary Care and General Practice, University of Birmingham, Birmingham B15 2TT
    BMJ 330:940. 2005
    ..To measure the coverage and uptake of systematic postal screening for genital Chlamydia trachomatis and the prevalence of infection in the general population in the United Kingdom. To investigate factors associated with these measures...
  44. ncbi Mice deficient in MyD88 Develop a Th2-dominant response and severe pathology in the upper genital tract following Chlamydia muridarum infection
    Lili Chen
    Department of Microbiology and Immunology, University of Texas Health Science Center, San Antonio, TX 78229, USA
    J Immunol 184:2602-10. 2010
    ....
  45. pmc Internet-based screening for sexually transmitted infections to reach nonclinic populations in the community: risk factors for infection in men
    Shua J Chai
    Department of Epidemiology, Johns Hopkins School of Public Health, Baltimore, MD 21205, USA
    Sex Transm Dis 37:756-63. 2010
    ..We studied whether internet-based screening was acceptable and reached a high-risk population, and what risk factors were associated with STI positivity...
  46. ncbi Comparative model-based analysis of screening programs for Chlamydia trachomatis infections
    M Kretzschmar
    Department of Infectious Disease Epidemiology, National Institute of Public Health and the Environment RIVM, Bilthoven, The Netherlands
    Am J Epidemiol 153:90-101. 2001
    ..Partner referral contributes substantially to prevalence reduction...
  47. ncbi Endogenous IFN-gamma production is induced and required for protective immunity against pulmonary chlamydial infection in neonatal mice
    Madhulika Jupelli
    South Texas Center for Emerging Infectious Diseases, Department of Biology, University of Texas, San Antonio, TX 78249, USA
    J Immunol 180:4148-55. 2008
    ..The enhanced IFN-gamma induction in the immature neonatal lung also may be relevant to the development of respiratory sequelae in adult life...
  48. pmc Rationale, design, and results of the first screening round of a comprehensive, register-based, Chlamydia screening implementation programme in the Netherlands
    Jan E A M van Bergen
    STI AIDS Netherlands, Amsterdam, The Netherlands
    BMC Infect Dis 10:293. 2010
    ..Here, we describe the rationale, design, and implementation of a Chlamydia screening demonstration programme...
  49. ncbi Who participates in the Dutch Chlamydia screening? A study on demographic and behavioral correlates of participation and positivity
    Eline L M Op de Coul
    Epidemiology and Surveillance Unit, Centre for Infectious Disease Control, National Institute of Public Health and the Environment, Bilthoven, The Netherlands
    Sex Transm Dis 39:97-103. 2012
    ..We studied who was reached in the first screening round by relating participation and chlamydia positivity to sociodemographic and sexual risk factors...
  50. pmc Repeated Chlamydia trachomatis genital infections in adolescent women
    Byron E Batteiger
    Divisions of Infectious Diseases, Indiana University School of Medicine, Indianapolis, Indiana 46202 5112, USA
    J Infect Dis 201:42-51. 2010
    ..Repeated Chlamydia trachomatis infections are common among young sexually active women. The relative frequency of reinfection and antibiotic treatment failure is undefined...
  51. pmc Performance of the Abbott RealTime CT/NG for detection of Chlamydia trachomatis and Neisseria gonorrhoeae
    C A Gaydos
    Johns Hopkins University, 855 North Wolfe St, 530 Rangos Building, Baltimore, MD 21205, USA
    J Clin Microbiol 48:3236-43. 2010
    ..trachomatis and N. gonorrhoeae dual detection with high sensitivity and specificity. The automated assay provides a useful alternative nucleic acid amplification assay for clinical laboratories and clinicians...
  52. pmc Hypoxia abrogates antichlamydial properties of IFN-γ in human fallopian tube cells in vitro and ex vivo
    Anna Roth
    Institute of Medical Microbiology and Hygiene, Center for Structural and Cell Biology in Medicine, University of Luebeck, 23538 Luebeck, Germany
    Proc Natl Acad Sci U S A 107:19502-7. 2010
    ..trachomatis depend on the environmental oxygen supply, which could explain inadequate bacterial clearance and subsequent chronic infections eventually occurring in the UGT of women...
  53. ncbi The arrested immunity hypothesis and the epidemiology of chlamydia control
    Robert C Brunham
    Sex Transm Dis 35:53-4. 2008
  54. pmc The Chlamydia trachomatis plasmid is a transcriptional regulator of chromosomal genes and a virulence factor
    John H Carlson
    Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 903 South 4th Street, Hamilton, MT 59840, USA
    Infect Immun 76:2273-83. 2008
    ..Our findings have important implications in understanding a role for the plasmid in the pathogenesis of human infection and disease...
  55. pmc Vaccination with the Chlamydia trachomatis major outer membrane protein can elicit an immune response as protective as that resulting from inoculation with live bacteria
    Sukumar Pal
    Department of Pathology and Laboratory Medicine, Medical Sciences I, Room D440, University of California, Irvine, Irvine, CA 92697 4800, USA
    Infect Immun 73:8153-60. 2005
    ..05). In conclusion, immunization with a purified preparation of the MOMP is as effective as vaccination with viable C. trachomatis in eliciting a protective immune response against a genital challenge in mice...
  56. pmc Isolates of Chlamydia trachomatis that occupy nonfusogenic inclusions lack IncA, a protein localized to the inclusion membrane
    R J Suchland
    Division of Allergy and Infectious Diseases, School of Medicine, University of Washington, Seattle, Washington, USA
    Infect Immun 68:360-7. 2000
    ..trachomatis isolates that form nonfusing inclusions; the variant phenotype is associated with the absence of detectable IncA and with an altered incA sequence that modifies the characteristic hydrophobic domain of the IncA protein...
  57. pmc Modelling the effectiveness of chlamydia screening in England
    K M E Turner
    Health Protection Agency, Centre for Infections, 61 Colindale Ave, Colindale, London NW9 5EQ, UK
    Sex Transm Infect 82:496-502. 2006
    ..Mathematical models can incorporate these non-linear effects and estimate the likely impact of different screening programmes and identify areas where more data are needed...
  58. pmc Predicting phenotype and emerging strains among Chlamydia trachomatis infections
    Deborah Dean
    Children s Global Health Initiativ, Children s Hospital Oakland Research Institute, Oakland, California 94609, USA
    Emerg Infect Dis 15:1385-94. 2009
    ..Multilocus and SNP typing can now be used to detect diverse and emerging C. trachomatis strains for epidemiologic and evolutionary studies of trachoma and STI populations worldwide...
  59. ncbi Interleukin-1 is the initiator of Fallopian tube destruction during Chlamydia trachomatis infection
    Malene Hvid
    Institute of Medical Microbiology and Immunology, University of Aarhus, The Bartholin Building, 8000 Aarhus C, Denmark
    Cell Microbiol 9:2795-803. 2007
    ..trachomatis infection. Because leukocytes are absent in the ex vivo model, this study strongly indicates that IL-1 is the initial proinflammatory cytokine activated by C. trachomatis infection...
  60. ncbi Transmission dynamics of Chlamydia trachomatis affect the impact of screening programmes
    Christian L Althaus
    Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland
    Epidemics 2:123-31. 2010
    ..However, due to the slower turnover of the infection, a substantial reduction in prevalence can only be achieved after screening for several years or decades...
  61. ncbi Acceptability of the internet-based Chlamydia screening implementation in the Netherlands and insights into nonresponse
    Katie E Greenland
    Epidemiology and Surveillance Unit, Centre for Infectious Disease Control, National Institute of Public Health and the Environment, Bilthoven, The Netherlands
    Sex Transm Dis 38:467-74. 2011
    ....
  62. pmc Chlamydia trachomatis strains and virulence: rethinking links to infection prevalence and disease severity
    Gerald I Byrne
    Department of Molecular Sciences, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    J Infect Dis 201:S126-33. 2010
    ....
  63. pmc Restricted fusion of Chlamydia trachomatis vesicles with endocytic compartments during the initial stages of infection
    Marci A Scidmore
    Host Parasite Interactions Section, Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, Montana 59840, USA
    Infect Immun 71:973-84. 2003
    ....
  64. pmc High frequency of chlamydial co-infections in clinically healthy sheep flocks
    Hannah Lenzko
    Institut für bakterielle Infektionen und Zoonosen, Friedrich Loeffler Institut, Naumburger Strasse 96a, 07743 Jena, Germany
    BMC Vet Res 7:29. 2011
    ..Seven vaccinated flocks were reviewed separately...
  65. ncbi Chlamydia trachomatis uses host cell dynein to traffic to the microtubule-organizing center in a p50 dynamitin-independent process
    Scott S Grieshaber
    Host Parasite Interactions Section, Laboratory of Intracellular Parasites, NIAID, NIH, Rocky Mountain Laboratories, Hamilton, MT 59840, USA
    J Cell Sci 116:3793-802. 2003
    ....
  66. ncbi The natural course of Chlamydia trachomatis infection in asymptomatic Colombian women: a 5-year follow-up study
    Monica Molano
    Department of Pathology, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    J Infect Dis 191:907-16. 2005
    ..4 [95% CI, 0.1-0.9]), compared with that for serovars of the intermediate group (F and G). At 4 years of follow-up, 94% of the women had cleared their infections...
  67. ncbi Australian general practitioner chlamydia testing rates among young people
    Fabian Y S Kong
    Centre for Population Health, Burnet Institute, Melbourne, Vic, Australia
    Med J Aust 194:249-52. 2011
    ..To describe the proportion of 16-29-year-olds tested for chlamydia by Australian general practitioners in a 12-month period...
  68. pmc Risk of cervical cancer associated with Chlamydia trachomatis antibodies by histology, HPV type and HPV cofactors
    Margaret M Madeleine
    Program in Epidemiology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Int J Cancer 120:650-5. 2007
    ..0-5.1), but not for the 4 types (C, F, H, and K) that were present at very low prevalence in this population. There was an increased risk of SCC, but not AC, associated with antibodies to C. trachomatis that was not serotype specific...
  69. pmc Toll-like receptor 2 activation by Chlamydia trachomatis is plasmid dependent, and plasmid-responsive chromosomal loci are coordinately regulated in response to glucose limitation by C. trachomatis but not by C. muridarum
    CATHERINE M O'CONNELL
    Department of Pediatrics, Children s Hospital of Pittsburgh of UPMC, 3705 Fifth Avenue, Pittsburgh, PA 15213, USA
    Infect Immun 79:1044-56. 2011
    ..Glucose-limited C. trachomatis displayed reduced TLR2 stimulation in an in vitro assay. During human chlamydial infection, glucose limitation may decrease chlamydial virulence through its effects on plasmid-responsive chromosomal genes...
  70. ncbi Gonorrhea and chlamydia in the United States among persons 14 to 39 years of age, 1999 to 2002
    S Deblina Datta
    Division of STD Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Ann Intern Med 147:89-96. 2007
    ..Nationally representative surveys of chlamydia and gonorrhea are an important measure of disease burden and progress of screening programs...
  71. pmc Simplifying chlamydia testing: an innovative Chlamydia trachomatis testing approach using the internet and a home sampling strategy: population based study
    D P Novak
    Department of Public Health and Clinical Medicine, Family Medicine, University of Umea, SE 901 85 Umea, Sweden
    Sex Transm Infect 82:142-7; discussion 152-3. 2006
    ..To investigate factors associated with these measures...
  72. pmc A predominant role for antibody in acquired immunity to chlamydial genital tract reinfection
    Sandra G Morrison
    Division of Infectious Diseases, Department of Medicine, University of Alabama, Birmingham 35294 0007, USA
    J Immunol 175:7536-42. 2005
    ..These results impact our understanding of immunity to chlamydial genital infection and may provide important insight into vaccine development...
  73. pmc Actin and intermediate filaments stabilize the Chlamydia trachomatis vacuole by forming dynamic structural scaffolds
    Yadunanda Kumar
    Department of Molecular Genetics and Microbiology and Center for Microbial Pathogenesis, Duke University Medical Center, Durham, NC 27710, USA
    Cell Host Microbe 4:159-69. 2008
    ..We propose that Chlamydia has co-opted the function of F-actin and IFs to stabilize the inclusion with a dynamic, structural scaffold while minimizing the exposure of inclusion contents to cytoplasmic innate immune-surveillance pathways...
  74. pmc Keeping participants on board: increasing uptake by automated respondent reminders in an Internet-based chlamydia screening in the Netherlands
    Nynke F B Dokkum
    Cluster of Infectious Diseases, Amsterdam Health Service, Amsterdam, The Netherlands
    BMC Public Health 12:176. 2012
    ....
  75. pmc "...they should be offering it": a qualitative study to investigate young peoples' attitudes towards chlamydia screening in GP surgeries
    Angela H Hogan
    Health Protection Agency, Primary Care Unit, Gloucester Royal Hospital, Gloucester, UK
    BMC Public Health 10:616. 2010
    ..This study aimed to identify the attitudes to, and preferences for, chlamydia screening in 15-24 year old men and women attending GP surgeries (the target group)...
  76. pmc Evaluation of the Abbott RealTime CT/NG assay in comparison to the Roche Cobas Amplicor CT/NG assay
    Annie Cheng
    Department of Pathology, Beth Israel Deaconess Medical Center, 330 Brookline Ave, YA309, Boston, MA 02215, USA
    J Clin Microbiol 49:1294-300. 2011
    ..gonorrhoeae and small amounts of C. trachomatis organisms. In summary, we conclude that the Abbott RealTime CT/NG assay is an accurate and automated new addition to the available testing options for C. trachomatis and N. gonorrhoeae...
  77. ncbi A multi-subunit chlamydial vaccine induces antibody and cell-mediated immunity in immunized koalas (Phascolarctos cinereus): comparison of three different adjuvants
    Alison J Carey
    Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, QLD, Australia
    Am J Reprod Immunol 63:161-72. 2010
    ..Little is known about the immune response in koalas, or the safety of commonly used adjuvants for induction of protective systemic and mucosal immunity...
  78. ncbi Willingness to offer chlamydia testing in general practice in New South Wales
    Asaduzzaman Khan
    Department of Statistics, University of Dhaka, Bangladesh
    Aust N Z J Public Health 30:226-30. 2006
    ..To assess willingness of general practitioners (GPs) to offer chlamydia testing to patients, and to identify demographic and practice correlates associated with willingness to offer chlamydia testing...
  79. ncbi Describing the progression from Chlamydia trachomatis and Neisseria gonorrhoeae to pelvic inflammatory disease: systematic review of mathematical modeling studies
    Sereina A Herzog
    Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland
    Sex Transm Dis 39:628-37. 2012
    ..A systematic review was conducted to determine how the natural history of Chlamydia trachomatis or Neisseria gonorrhoeae infection and progression to PID have been described in mathematical modeling studies...
  80. pmc Risk of pelvic inflammatory disease following Chlamydia trachomatis infection: analysis of prospective studies with a multistate model
    Malcolm J Price
    School of Health and Population Sciences, Public Health Building, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom
    Am J Epidemiol 178:484-92. 2013
    ..Assuming a piecewise homogenous model with a higher rate during the first 60 days, corresponding results were 0.16 (95% CrI: 0.07, 0.26) and 55% (95% CrI: 32, 72), respectively. ..
  81. pmc Chlamydia trachomatis infection causes mitotic spindle pole defects independently from its effects on centrosome amplification
    Andrea E Knowlton
    Department of Oral Biology, College of Dentistry, University of Florida, Gainesville, FL 32610, USA
    Traffic 12:854-66. 2011
    ..We hypothesize that these combined effects on mitotic spindle architecture identifies a possible mechanism for Chlamydia as a cofactor in cervical cancer formation...
  82. ncbi Chlamydia trachomatis infection & female infertility
    Abida Malik
    Department of Microbiology, Aligarh Muslim University, Aligarh, India
    Indian J Med Res 123:770-5. 2006
    ..trachomatis is increasingly being associated with long-term complications like infertility. The present study was undertaken to assess the role of C. trachomatis in female infertility as such data are lacking...
  83. ncbi Association of CCR5, TLR2, TLR4 and MBL genetic variations with genital tract infections and tubal factor infertility
    Triin Laisk
    Department of Obstetrics and Gynecology, University of Tartu, L Puusepa 8, 51014 Tartu, Estonia
    J Reprod Immunol 87:74-81. 2010
    ..Overall, these data suggest that polymorphisms in TLR4 and MBL2 play a role in receptiveness to pathogens causing genital tract infections, while MBL2 genotypes contribute to susceptibility to tubal factor infertility...
  84. ncbi The efficacy of clinic-based interventions aimed at increasing screening for bacterial sexually transmitted infections among men who have sex with men: a systematic review
    Huachun Zou
    Sexual Health Unit, School of Population Health, University of Melbourne, Melbourne, Vic, Australia
    Sex Transm Dis 39:382-7. 2012
    ..We undertook a systematic review to identify clinic-based strategies for increasing screening and detection of bacterial STIs among MSM...
  85. ncbi Population-based outreach for Chlamydia screening in men: results from a randomized trial
    Delia Scholes
    Center for Health Studies, Group Health Cooperative, Seattle, WA 98101, USA
    Sex Transm Dis 34:837-9. 2007
    ..To evaluate the feasibility and efficacy of population-based outreach strategies to improve genital Chlamydia trachomatis (CT) screening in men...
  86. pmc Interaction of microbiology and pathology in women undergoing investigations for infertility
    Joseph Debattista
    Sexual Health and AIDS Service, Prince Charles Hospital, Health Service District, Brisbane, Australia
    Infect Dis Obstet Gynecol 12:135-45. 2004
    ....
  87. pmc Caspase-1 dependent IL-1β secretion is critical for host defense in a mouse model of Chlamydia pneumoniae lung infection
    Kenichi Shimada
    Division of Pediatrics Infectious Disease and Immunology, Cedars Sinai Medical Center and David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 6:e21477. 2011
    ..Interestingly, Caspase-1 activation during CP infection occurs with mitochondrial dysfunction indicating a possible mechanism involving the mitochondria for CP-induced inflammasome activation...
  88. pmc CXCR3 and CCR5 are both required for T cell-mediated protection against C. trachomatis infection in the murine genital mucosa
    A J Olive
    Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts, USA
    Mucosal Immunol 4:208-16. 2011
    ..These results show that CXCR3 and CCR5 are the predominant chemokine receptors that act cooperatively to promote homing to the genital mucosa during Chlamydia infection...
  89. pmc Multi locus sequence typing of Chlamydiales: clonal groupings within the obligate intracellular bacteria Chlamydia trachomatis
    Yvonne Pannekoek
    Department of Medical Microbiology, Center for Infection and Immunity Amsterdam CINIMA, Academic Medical Center, Amsterdam, The Netherlands
    BMC Microbiol 8:42. 2008
    ..We developed a multi locus sequence typing (MLST) scheme to understand the population genetic structure and diversity of these species and to evaluate the association between genotype and disease...
  90. pmc Population prevalence of Chlamydia trachomatis and Neisseria gonorrhoeae in the Netherlands. Should asymptomatic persons be tested during population-based Chlamydia screening also for gonorrhoea or only if chlamydial infection is found?
    Jan E A M van Bergen
    STI AIDS Netherlands Soa Aids Nederland, Amsterdam, The Netherlands
    BMC Infect Dis 6:42. 2006
    ..Screening and active case finding for Chlamydia trachomatis (CT) is recommended to prevent reproductive morbidity. However insight in community prevalence of gonococcal infections and co-infections with Neisseria gonorrhoea (NG) is lacking...
  91. pmc Contact tracing to control infectious disease: when enough is enough
    Benjamin Armbruster
    Department of Management Science and Engineering, Stanford University, Stanford, CA 94305 4026, USA
    Health Care Manag Sci 10:341-55. 2007
    ..We present an example application to contact tracing for chlamydia control...
  92. pmc Detection of Chlamydia trachomatis and Neisseria gonorrhoeae by enzyme immunoassay, culture, and three nucleic acid amplification tests
    E Van Dyck
    STD HIV Research and Intervention Unit, Department of Microbiology, Institute of Tropical Medicine, Nationalestraat 155, B 2000 Antwerp, Belgium
    J Clin Microbiol 39:1751-6. 2001
    ..trachomatis EIA. The accuracies of the different NAATs were quite similar. SDA was the only amplification assay with 100% specificity for detection of both N. gonorrhoeae and C. trachomatis in endocervical specimens...
  93. ncbi Neonatal chlamydial pneumonia induces altered respiratory structure and function lasting into adult life
    Madhulika Jupelli
    Department of Biology, South Texas Center for Emerging Infectious Disease, University of Texas at San Antonio, San Antonio, TX 78249, USA
    Lab Invest 91:1530-9. 2011
    ..The results of our studies also emphasize the importance of prenatal screening and treatment of pregnant women for C. trachomatis in order to prevent the infection of neonates...
  94. ncbi Genotyping of Chlamydia trachomatis from clinical specimens in Taiwan
    Min Chih Hsu
    Laboratory for Bacteriology and Mycology, Center for Laboratory Research and Diagnostics, Center for Disease Control, Taipei, Taiwan
    J Med Microbiol 55:301-8. 2006
    ..018) between northern and southern Taiwan. Sequence mutation analysis by blast searching against GenBank reference sequences identified 12 genetic variants from a total of 102 omp1 gene sequences...
  95. ncbi Fitz-Hugh-Curtis syndrome. Radiologic manifestation
    Akihiro Nishie
    Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Comput Assist Tomogr 27:786-91. 2003
    ..To clarify radiologic findings of Fitz-Hugh-Curtis syndrome (FHCS)...
  96. ncbi Characterisation of Chlamydia trachomatis by ompA sequencing and multilocus sequence typing in a Swedish county before and after identification of the new variant
    Margaretha Jurstrand
    Clinical Research Centre, Orebro University Hospital, Orebro SE 70185, Sweden
    Sex Transm Infect 86:56-60. 2010
    ..The study also aimed to evaluate the discriminatory capacity of multilocus sequence typing (MLST) compared with ompA sequencing...
  97. ncbi Predicting the population impact of chlamydia screening programmes: comparative mathematical modelling study
    M Kretzschmar
    Julius Centre for Health Sciences and Primary Care, University Medical Centre Utrecht, Utrecht, The Netherlands
    Sex Transm Infect 85:359-66. 2009
    ..The objective of this study was to conduct a direct comparison of the effect of organised chlamydia screening in different models...
  98. ncbi Prevalence of Mycoplasma genitalium among female students in vocational schools in Japan
    R Hamasuna
    Division of Urology, Department of Surgery, Faculty of Medicine, University of Miyazaki, Kiyotake, Miyazaki 889 1692, Japan
    Sex Transm Infect 84:303-5. 2008
    ..The objective of this study was to determine the prevalence of M genitalium infection among younger females and to determine risk factors for this infection...
  99. ncbi Untreated gonococcal and chlamydial infection in a probability sample of adults
    Charles F Turner
    Program in Health and Behavior Measurement, Research Triangle Institute, 1615 M St NW, Washington, DC 20036, USA
    JAMA 287:726-33. 2002
    ..Development of nucleic acid amplification tests, such as the ligase chain reaction assay, provides new opportunities to estimate the prevalence of untreated infections in the population...
  100. ncbi Chlamydia muridarum infection subverts dendritic cell function to promote Th2 immunity and airways hyperreactivity
    Gerard E Kaiko
    School of Biomedical Sciences and The Asthma and Respiratory Diseases Priority Research Centre, University of Newcastle and Hunter Medical Research Institute, Newcastle, Australia
    J Immunol 180:2225-32. 2008
    ..In the setting of allergic airways inflammation, this infection may then contribute to exacerbation of the asthmatic phenotype...
  101. ncbi Neonatal chlamydial infection induces mixed T-cell responses that drive allergic airway disease
    Jay C Horvat
    Priority Research Centre for Asthma and Respiratory Disease, School of Biomedical Sciences, Faculty of Health, University of Newcastle, Newcastle, Australia
    Am J Respir Crit Care Med 176:556-64. 2007
    ..Chlamydial lung infection has been associated with asthma in children and adults. However, how chlamydial infection influences the development of immune responses that promote asthma remains unknown...

Research Grants64

  1. Chaperone Mining of the Chlamydia Type Three Secretion System
    ELLENA MARIE PETERSON; Fiscal Year: 2010
    ..in host cells is fundamental to our efforts to design effective therapies that can aid in the prevention of Chlamydia infections. It has recently been shown that Chlamydia possesses genes for a type three secretion (TTS) system...
  2. A Point of Care, Nucleic Acid Test for Chlamydia to Ensure Prompt Treatment of He
    LAURA T MAZZOLA; Fiscal Year: 2013
    ..test into a community clinic testing program, toward the goal of increasing early identification of chlamydia infections in populations that are disproportionately affected...
  3. High throughput proteomics to dissect Chlamydia-host cell interactions
    Joanne N Engel; Fiscal Year: 2013
    ..will yield important clues into the pathogenesis of Chlamydia respiratory infections, the role of Chlamydia infections in atherosclerotic heart disease, and the role of Chlamydia infections in lung cancer...
  4. Mechanism of Chlamydia-induced centrosome amplification
    Ming Tan; Fiscal Year: 2010
    b>Chlamydia infections are the most commonly reported infectious disease in the U.S...
  5. Immunomodulation and Vaccine Optimization against Chlamydia
    Qing He; Fiscal Year: 2013
    ..In the United States 1,108,374 Chlamydia infections were reported to the Centers for Disease Prevention and Control in 2007...
  6. Regulation of Virulence Gene Expression in Chlamydia
    P Scott Hefty; Fiscal Year: 2013
    ..will allow in the future for rationale design of novel molecules that interrupt the function of ChxR and Chlamydia infections. PUBLIC HEALTH RELEVANCE: Proposed studies will facilitate our understanding of how and what controls the ..
  7. Immunoregulatory Networks in Chlamydia Genital Tract Infection
    Amy M Scurlock; Fiscal Year: 2013
    ..devastating reproductive complications, such as infertility and ectopic pregnancy, associated with Chlamydia infections. The research plan will evaluate the expanding diversity of effector and regulatory CD4+ T-cell responses ..
  8. Can Chlamydial Infection Increase Host Mutation Frequency?
    ROBERT SCHOBORG; Fiscal Year: 2009
    ..This proposal will begin to evaluate the possibility that chlamydia infections may damage host cell DNA, leading to mutations and, possibly, to cancer...
  9. Combination Antibotics as a Treatment for Chlamydia-Induced Reactive Arthritis
    John Carter; Fiscal Year: 2007
    ..This project will be a critical pathway in discovering a cure for persistent Chlamydia infections in the joint and at other anatomic sites...
  10. Functional Genomic Analysis of the Chlamydia Inclusion
    RAPHAEL VALDIVIA; Fiscal Year: 2005
    ..We will raise antibodies to these Chlamydia proteins to determine their subcellular localization during Chlamydia infections. In the last stage of the screen, we will use the antibodies and cell lines generated to determine if these ..
  11. Single Cell Expression Profiling of Chlamydia Genes
    MICHAEL STARNBACH; Fiscal Year: 2004
    ..expression in these organisms during their developmental cycle because of the difficulty in synchronizing Chlamydia infections. The use of FISH technology circumvents the problem of asynchronous infections because we will be able to ..
  12. MID AMERICA ADOLESCENT STD COOPERATIVE RESEARCH CENTER
    Donald Orr; Fiscal Year: 2003
    ..The other will examine the relationships of omp1 genotype, immune factors and repeated lower genital tract chlamydia infections in adolescent women...
  13. HIV Risk-reduction with Drug-using Youth
    Daniel Pilowsky; Fiscal Year: 2005
    ..use; and (4) To gather descriptive epidemiological data on the prevalence and incidence of gonorrheal and Chlamydia infections among the index NIDUs enrolled in the clinical trial...
  14. Immune Responses in Genital Chlamydia Prior to Therapy
    WILLIAM GEISLER; Fiscal Year: 2005
    ..abstract_text> ..
  15. Host response to Chlamydia genital infection in the male
    Roger Rank; Fiscal Year: 2008
    ..abstract_text> ..
  16. Potential for HIV transmission in relationships of drug-using women in Russia
    Linda Niccolai; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  17. BLOCKING INFECTIOUS ENTRY OF STD PATHOGENS
    Richard Cone; Fiscal Year: 2003
    ..lines, to determine whether monoclonals that have been taken up by epithelial cells are effective for blocking HIV, HSV-2, and chlamydia infections, and for blocking adhesions and transepithelial migration of leukocytes.
  18. Host Factors in Susceptibility to Chlamydial Disease
    KYLE RAMSEY; Fiscal Year: 2006
    ....
  19. LOCAL IMMUNE RESPONSE IN CHLAMYDIA SALPINGITIS
    Dorothy Patton; Fiscal Year: 2003
    ..trachomatis- induced PID. If one chlamydial antigen is the major cause of the DTH response in PID, diagnostic or immunomodulatory efforts can be directed towards that antigen. ..
  20. Improved Macaque Safety Model for Topical Microbicides: Post-coital Assessments
    Dorothy Patton; Fiscal Year: 2008
    ..In addition, we will collect parallel assessments, when mating has occurred with a placebo gel (HEC universal placebo) in place. These studies will provide urgently needed data regarding topical microbicide use with coital activity. ..
  21. The Acquisition of Bacterial Vaginosis in Lesbians
    Jeanne Marrazzo; Fiscal Year: 2006
    ..Lesbian couples provide a unique opportunity to conduct comparative studies of vaginal microbial ecology in sex partners, and to directly analyze determinants of transmission. ..
  22. Inflammation and Ovarian Cancer
    Clareann Bunker; Fiscal Year: 2008
    ..In particular, NSAID use may prove to be a potentially important chemopreventative for this often-fatal disease. ..
  23. Spatial Epidemiology of Syphilis and Gonorrhea in North Carolina
    William C Miller; Fiscal Year: 2010
    ..Furthermore, we will obtain critical, new information regarding STI epidemiology in southeastern U.S., a region with disproportionate burden of these infections. ..
  24. CELLULAR TRAFFICKING TO INFLAMED FEMALE GENITAL MUCOSA
    Kathleen Kelly; Fiscal Year: 2007
    ..Insight into CXCL13 secretion will impact public health and the welfare of women in the US by aiding the development of therapeutics to prevent tubal infertility. ..
  25. Chlamydia trachomatis, Genital Flora, & STD Pathogenesis
    Gerald Byrne; Fiscal Year: 2004
    ..This hypothesis will be tested by determining the effects of indole-producing normal flora on chlamydial genital tract disease in a well-characterized murine model. ..
  26. A community-level RCT of expedited partner treatment for gonorrhea and chlamydia
    Matthew R Golden; Fiscal Year: 2010
    ..abstract_text> ..
  27. Prevention of Infertility in Women With Subclinical PID
    HAROLD WIESENFELD; Fiscal Year: 2007
    ..During this study, very real public health questions will be asked and answered which will affect the way that lower genital tract infections are routinely managed, potentially enhancing fertility among American women. ..
  28. Oral Contraceptive Use and Bone Density in Young Women
    Delia Scholes; Fiscal Year: 2008
    ..abstract_text> ..
  29. Urinary Symptoms in Adolescent Females: STI or UTI?
    Jill Huppert; Fiscal Year: 2004
    ..The findings of this study will strengthen the evidence base for symptom-based STI testing of SA adolescent females and will promote care that addresses both individual patient and public health needs. ..
  30. C. trachomatis genomics, strain typing, and evolution
    Deborah Dean; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  31. Pathogenesis of Persistent Chlamydial STDs
    Deborah Dean; Fiscal Year: 2007
    ..1 Description, ..
  32. PATHOGENIC MECHANISMS IN UTI
    Walter Stamm; Fiscal Year: 2007
    ..Face Page .................................................................................................. 1 B. Description, ..
  33. Prophylactic Ibuprofen: Effect on IUD Continuation Rates
    David Hubacher; Fiscal Year: 2003
    ..In the US, ibuprofen may help spur renewed interest in the most cost effective and efficacious reversible contraceptive method available. ..
  34. Immunobiology of Chlamydia
    Raymond Johnson; Fiscal Year: 2004
    ..T cell culture system that he developed during prior training to study the mucosal immune response to chlamydia infections of the reproductive tract...
  35. PATHOGENESIS OF CHLAMYDIAL OCULAR INFECTIONS
    Deborah Dean; Fiscal Year: 2004
    ..A greater understanding of the pathogenesis of trachoma will aid in developing public health interventions and a vaccine that can be implemented in trachoma endemic areas throughout the world. ..
  36. Exacerbation of Atherosclerosis
    Guangming Zhong; Fiscal Year: 2004
    ..pneumoniae exacerbation of atherosclerosis will be evaluated. These studies may provide the essential information on designing effective approaches for preventing and controlling C. pneumoniae-exacerbated atherosclerosis. ..
  37. Cellular Immunity to Chlamydua at the Epithelial Interface
    RAYMOND MORRIS JOHNSON; Fiscal Year: 2010
    ..Defining what protective T cells look like, and how they function, will be critical for designing and assessing future Chlamydia candidate vaccines. ..
  38. Chlamydial Manipulation of Host Apoptosis
    Guangming Zhong; Fiscal Year: 2010
    ..abstract_text> ..
  39. Ectopic Pregnancy: Assessing Long-Term Trends in Rates and Risk Factors
    Delia Scholes; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  40. MEASURING HIV RISK IN A CLINIC POPULATION
    Susan Rogers; Fiscal Year: 2001
    ..They will use the new sperm assay plus urine-based assays for gonorrhea and chlamydial infection to validate measures of recent unprotected intercourse. ..
  41. Chlamydia-infected Epithelial Cell Secretion of Immunoregulatory Cytokines
    WILBERT DERBIGNY; Fiscal Year: 2008
    ..unreadable] DESCRIPTION (provided by applicant): NO ABSTRACT WAS PROVIDED BY THE PI. [unreadable] [unreadable] [unreadable] [unreadable]..
  42. Monitoring STI's in the Population
    Susan Rogers; Fiscal Year: 2009
    ..This research takes the next step toward this goal - moving from studying the prevalence of untreated infections to tracking changes over time in the prevalence, distribution, and correlates of these untreated infections. ..
  43. VIRULENCE FACTORS OF CHLAMYDIAE
    PRISCILLA WYRICK; Fiscal Year: 2009
    ....
  44. AFFECT AND MARIJUANA USE IN ADOLESCENTS AND YOUNG ADULTS
    Lydia Shrier; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  45. Therapy and Prevention for Bacterial Vaginosis
    Jane Schwebke; Fiscal Year: 2006
    ..We will also utilize specimens from these prospective studies to further study the association of Mobiluncus, an organism strongly associated with BV using sensitive PCR technology. ..
  46. STD Screening in Young Women: A Stage-based Intervention
    MARIAM CHACKO; Fiscal Year: 2003
    ..Secondary outcomes will include progression through the Stages of Change for STH screening, the frequency of consistent condom use during the past 30 days and number of episodes of gonococcal or chlamydial infections over 12 months. ..
  47. MENTAL HEALTH AND BEHAVIOR IN ADOLESCENT STD PREVENTION
    Lydia Shrier; Fiscal Year: 2003
    ....
  48. Concordance Rates of Mobiluncus Among Sexual Partners
    Jane Schwebke; Fiscal Year: 2004
    ..Our hypothesis is that Mobiluncus curtisii is important in the pathogenesis of BV and high concordance rates among sexual partners will be found suggesting sexual transmission. ..
  49. REDUCING HIV RISK IN FEMALE TEENS: A TAILORED APPROACH
    Ralph DiClemente; Fiscal Year: 2004
    ..abstract_text> ..
  50. Transmissibility of GC and Ct Diagnosed using NAAT
    Susan Rogers; Fiscal Year: 2004
    ....
  51. ATTENDED CITY SCHOOLYARDS TO INCREASE PHYSICAL ACTIVITY
    Thomas Farley; Fiscal Year: 2004
    ....
  52. Validating Sexual Behavior by Y-chromosome PCR
    Jonathan Zenilman; Fiscal Year: 2005
    ..Since Yc sampling requires only a vaginal swab, and is stable under field conditions, this test promises to be a practical and easily used biomarker for sexual behavior research. ..
  53. Teens and Exposure to HIV Risk on the Web
    Ralph DiClemente; Fiscal Year: 2005
    ..Given the controversy surrounding teens' exposure to sexual content on the Web, there is a compelling need to examine the impact of these exposures on teens' sexual health. ..
  54. Recovery of Vaginal Flora after Douching Cessation
    Jonathan Zenilman; Fiscal Year: 2006
    ..Data from this research will begin to describe the natural history of BV and aid in the design of behavioral interventions for vaginal douching. [unreadable] [unreadable]..
  55. Reiter's syndrome mechanism of chlamydial pathogenesis
    Alan Hudson; Fiscal Year: 2008
    ....
  56. Tinidazole for the Treatment of Bacterial Vaginosis
    Jane Schwebke; Fiscal Year: 2007
    ..In addition, we will measure vaginal and serum concentrations of drug during treatment and correlate with cure rates, short-term recurrence of BV, and severity of infection. ..
  57. Role of Chlamydia Pneumoniae in Atherosclerosis
    Cho Chou Kuo; Fiscal Year: 2007
    ..pneumoniae infection and reduction of atherosclerosis and coronary heart disease. ..
  58. CLINICAL RESEARCH IN STDS
    Jonathan Zenilman; Fiscal Year: 2007
    ..Mentees at all levels are expected to develop an independent research project resulting in presentation at national meetings and publication. ..
  59. Control of Trichomoniasis -A Paradigm for STD Control
    Jane Schwebke; Fiscal Year: 2006
    ..vaginalis, to examine strain differences using PFGE, and to examine the prevalence of resistance strains and their potential contribution to treatment failure. ..
  60. Mood and HIV Risk in Depressed Adolescents
    Lydia Shrier; Fiscal Year: 2006
    ..Enhancing our understanding of the associations of mood and risk behavior among depressed adolescents will be essential to the development ns designed specifically for this at-risk population. ..
  61. CHLAMYDIA PNEUMONIAE--A PATHOGEN IN ALZHEIMERS DISEASE
    Alan Hudson; Fiscal Year: 2002
    ..Such new information may well provide important new insights for development of novel therapeutic modalities to prevent or ameliorate late-onset AD. ..
  62. HOMELESS YOUTH: STREET CULTURE/SOCIAL NETWORKS/HIV-RISK
    Colette Auerswald; Fiscal Year: 2005
    ..An understanding of how social network connections promote and prevent risky behaviors would also have significant implications for the designing of interventions with this population. ..
  63. HIV Risk Among Homeless Mothers
    CAROL CATON; Fiscal Year: 2007
    ..The study will inform the design of HIV risk behavior preventive interventions appropriate to the life circumstances of homeless mothers. ..