bacterial pneumonia

Summary

Summary: Pneumonia caused by various species of bacteria. Bacterial pneumonia commonly results from bronchogenic spread of infection following microaspiration of secretions. The largest category of this disease arises from community-acquired pneumonias.

Top Publications

  1. ncbi Infectious Diseases Society of America/American Thoracic Society consensus guidelines on the management of community-acquired pneumonia in adults
    Lionel A Mandell
    McMaster University Medical School, Hamilton, Ontario, Canada
    Clin Infect Dis 44:S27-72. 2007
  2. ncbi Community-acquired pneumonia
    Thomas M File
    Northeastern Ohio Universities College of Medicine, Rootstown, Ohio, and Infectious Disease Service, Summa Health System, Akron, Ohio, USA
    Lancet 362:1991-2001. 2003
  3. ncbi Soluble triggering receptor expressed on myeloid cells and the diagnosis of pneumonia
    Sebastien Gibot
    Service de Reanimation Medicale, Hopital Central, Nancy, France
    N Engl J Med 350:451-8. 2004
  4. ncbi Type III protein secretion is associated with poor clinical outcomes in patients with ventilator-associated pneumonia caused by Pseudomonas aeruginosa
    Alan R Hauser
    Department of Microbiology Immunology, Northwestern University, Chicago, IL, USA
    Crit Care Med 30:521-8. 2002
  5. ncbi Impact of the seven-valent pneumococcal conjugate vaccination (PCV7) programme on childhood hospital admissions for bacterial pneumonia and empyema in England: national time-trends study, 1997-2008
    Elizabeth Koshy
    Department of Primary Care and Public Health, Reynolds Building, Imperial College London, Charing Cross Campus, London W6 8RP, UK
    Thorax 65:770-4. 2010
  6. pmc Predominant role of bacterial pneumonia as a cause of death in pandemic influenza: implications for pandemic influenza preparedness
    David M Morens
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    J Infect Dis 198:962-70. 2008
  7. ncbi Microbial etiologies of hospital-acquired bacterial pneumonia and ventilator-associated bacterial pneumonia
    Ronald N Jones
    JMI Laboratories, North Liberty, Iowa 52317, USA
    Clin Infect Dis 51:S81-7. 2010
  8. ncbi Community-acquired pneumonia in Ugandan adults: short-term parenteral ampicillin therapy for bacterial pneumonia
    H Yoshimine
    Department of Internal Medicine and Information and Reference Center, Institute of Tropical Medicine, Nagasaki University, Japan
    Am J Trop Med Hyg 64:172-7. 2001
  9. pmc Increased circulating endothelial progenitor cells in patients with bacterial pneumonia: evidence that bone marrow derived cells contribute to lung repair
    M Yamada
    Department of Geriatric and Respiratory Medicine, Tohoku University School of Medicine, 1 1 Seiryoumachi, Aobaku, Sendai 980 8574, Japan
    Thorax 60:410-3. 2005
  10. pmc A systematic review on the diagnosis of pediatric bacterial pneumonia: when gold is bronze
    Tim Lynch
    Department of Pediatrics, Children s Hospital, University of Western Ontario, London, Ontario, Canada
    PLoS ONE 5:e11989. 2010

Detail Information

Publications278 found, 100 shown here

  1. ncbi Infectious Diseases Society of America/American Thoracic Society consensus guidelines on the management of community-acquired pneumonia in adults
    Lionel A Mandell
    McMaster University Medical School, Hamilton, Ontario, Canada
    Clin Infect Dis 44:S27-72. 2007
  2. ncbi Community-acquired pneumonia
    Thomas M File
    Northeastern Ohio Universities College of Medicine, Rootstown, Ohio, and Infectious Disease Service, Summa Health System, Akron, Ohio, USA
    Lancet 362:1991-2001. 2003
    ..The appropriate use of vaccines against pneumococcal disease and influenza should be encouraged. Several guidelines for management of CAP have recently been published, the recommendations of which are reviewed...
  3. ncbi Soluble triggering receptor expressed on myeloid cells and the diagnosis of pneumonia
    Sebastien Gibot
    Service de Reanimation Medicale, Hopital Central, Nancy, France
    N Engl J Med 350:451-8. 2004
    The diagnosis and treatment of bacterial pneumonia in patients who are receiving mechanical ventilation remain a difficult challenge...
  4. ncbi Type III protein secretion is associated with poor clinical outcomes in patients with ventilator-associated pneumonia caused by Pseudomonas aeruginosa
    Alan R Hauser
    Department of Microbiology Immunology, Northwestern University, Chicago, IL, USA
    Crit Care Med 30:521-8. 2002
    ..The objective of this study was to determine whether this system contributes to disease severity in humans with ventilator-associated pneumonia...
  5. ncbi Impact of the seven-valent pneumococcal conjugate vaccination (PCV7) programme on childhood hospital admissions for bacterial pneumonia and empyema in England: national time-trends study, 1997-2008
    Elizabeth Koshy
    Department of Primary Care and Public Health, Reynolds Building, Imperial College London, Charing Cross Campus, London W6 8RP, UK
    Thorax 65:770-4. 2010
    Childhood bacterial pneumonia and empyema rates have reportedly increased in recent years in Europe...
  6. pmc Predominant role of bacterial pneumonia as a cause of death in pandemic influenza: implications for pandemic influenza preparedness
    David M Morens
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    J Infect Dis 198:962-70. 2008
    ..Despite the availability of published data on 4 pandemics that have occurred over the past 120 years, there is little modern information on the causes of death associated with influenza pandemics...
  7. ncbi Microbial etiologies of hospital-acquired bacterial pneumonia and ventilator-associated bacterial pneumonia
    Ronald N Jones
    JMI Laboratories, North Liberty, Iowa 52317, USA
    Clin Infect Dis 51:S81-7. 2010
    Hospital-acquired bacterial pneumonia (HABP) and ventilator-associated bacterial pneumonia (VABP) can be caused by a wide variety of bacteria that originate from the patient flora or the health care environment...
  8. ncbi Community-acquired pneumonia in Ugandan adults: short-term parenteral ampicillin therapy for bacterial pneumonia
    H Yoshimine
    Department of Internal Medicine and Information and Reference Center, Institute of Tropical Medicine, Nagasaki University, Japan
    Am J Trop Med Hyg 64:172-7. 2001
    ..These data support the use of short-term parenteral ampicillin for patients with bacterial CAP irrespective of HIV-status...
  9. pmc Increased circulating endothelial progenitor cells in patients with bacterial pneumonia: evidence that bone marrow derived cells contribute to lung repair
    M Yamada
    Department of Geriatric and Respiratory Medicine, Tohoku University School of Medicine, 1 1 Seiryoumachi, Aobaku, Sendai 980 8574, Japan
    Thorax 60:410-3. 2005
    ..This study was undertaken to investigate the mobilisation of EPCs in humans following acute pneumonia...
  10. pmc A systematic review on the diagnosis of pediatric bacterial pneumonia: when gold is bronze
    Tim Lynch
    Department of Pediatrics, Children s Hospital, University of Western Ontario, London, Ontario, Canada
    PLoS ONE 5:e11989. 2010
    ..studies that have used single or multiple tests as a gold standard for assessing accuracy of other tests, and 2) given the 'gold standard' used, determine the accuracy of these other tests for diagnosing childhood bacterial pneumonia.
  11. ncbi Global strategies to prevent bacterial pneumonia in adults with HIV disease
    Daniel R Feikin
    Respiratory Diseases Branch, Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA
    Lancet Infect Dis 4:445-55. 2004
    We examined the peer-reviewed literature on the burden of bacterial pneumonia and the effectiveness of interventions for its prevention among HIV-infected adults in developed and developing countries...
  12. ncbi Epidemiology and etiology of community-acquired pneumonia
    Lionel A Mandell
    Division of Infectious Diseases, Department of Medicine, McMaster University, Henderson Site, 711 Concession Street, 40 Wing, 5th Floor, Room 503, Hamilton, ON Canada L8V 1C3
    Infect Dis Clin North Am 18:761-76, vii. 2004
    ..This article discusses the epidemiology and bacterial causes of CAP in immunocompetent adults and the severe acute respiratory syndrome coronavirus...
  13. ncbi Early mortality in patients with community-acquired pneumonia: causes and risk factors
    C Garcia-Vidal
    Infectious Disease Service, Hospital University of Bellvitge, Feixa Llarga s n 08907 L Hospitalet, Barcelona, Spain
    Eur Respir J 32:733-9. 2008
    ..Pneumococcal bacteraemia and discordant antibiotic therapy, mainly due to lack of coverage against Pseudomonas aeruginosa are also significant risk factors...
  14. ncbi What is ventilator-associated pneumonia and why is it important?
    Marin H Kollef
    Pulmonary and Critical Care Division, Washington University School of Medicine, Campus Box 8052, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Respir Care 50:714-21; discussion 721-4. 2005
    ..Additionally, clinical strategies aimed at the prevention of HAP and VAP should be employed in all hospital settings caring for patients at risk for these infections...
  15. ncbi Ventilator-associated pneumonia
    Jean Chastre
    Service de Reanimation Medicale, Groupe Hospitalier Pitie Salpetriere, France
    Am J Respir Crit Care Med 165:867-903. 2002
    ..Further trials will be needed to clarify the optimal duration of treatment and the circumstances in which monotherapy can be safely used...
  16. pmc Molecular analysis of oral and respiratory bacterial species associated with ventilator-associated pneumonia
    Farah K Bahrani-Mougeot
    Department of Oral Medicine, Carolinas Medical Center, P O Box 32861, Charlotte, NC 28232, USA
    J Clin Microbiol 45:1588-93. 2007
    ..Furthermore, it is clear that the diversity of bacterial pathogens for VAP is far more complex than the current literature suggests...
  17. ncbi A role for hydroxy-methylglutaryl coenzyme a reductase in pulmonary inflammation and host defense
    Michael B Fessler
    Department of Medicine, National Jewish Medical and Research Center, 1400 Jackson Street, D403 Neustadt, Denver, CO 80206, USA
    Am J Respir Crit Care Med 171:606-15. 2005
    ..No studies to date, however, have addressed whether statins modulate pulmonary inflammation triggered by aerogenic stimuli or whether they affect host defense...
  18. ncbi Secretion of the toxin ExoU is a marker for highly virulent Pseudomonas aeruginosa isolates obtained from patients with hospital-acquired pneumonia
    Grant S Schulert
    Department of Microbiology Immunology, Northwestern University, Chicago, Illinois 60611, USA
    J Infect Dis 188:1695-706. 2003
    ..Together, these findings suggest that secretion of ExoU is a marker for highly virulent strains of P. aeruginosa...
  19. ncbi Differential involvement of TLR2 and TLR4 in host survival during pulmonary infection with Chlamydia pneumoniae
    Nuria Rodriguez
    Institute of Medical Microbiology, Immunology and Hygiene, Technical University of Munich, Munich, Germany
    Eur J Immunol 36:1145-55. 2006
    ..All TLR2(-/-) x TLR4(d/d) mice succumbed to the infection, while about 50% of TLR2(-/-) mice died. Taken together, the function of TLR2 and TLR4 is required to survive pulmonary infection with C. pneumoniae...
  20. pmc Augmented lung inflammation protects against influenza A pneumonia
    Michael J Tuvim
    Department of Pulmonary Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    PLoS ONE 4:e4176. 2009
    ..We sought to determine whether lung inflammation promoted or impaired host survival in influenza pneumonia...
  21. pmc Bench-to-bedside review: bacterial pneumonia with influenza - pathogenesis and clinical implications
    Koenraad F Van Der Sluijs
    Departments of Pulmonology and Experimental Immunology, Academic Medical Center, Amsterdam, The Netherlands
    Crit Care 14:219. 2010
    ..Secondary bacterial respiratory infection can be subdivided into combined viral/bacterial pneumonia and post-influenza pneumonia, which differ in their pathogenesis...
  22. pmc Diagnostic and prognostic accuracy of clinical and laboratory parameters in community-acquired pneumonia
    Beat Muller
    Departments of Internal Medicine, University Hospital, Petersgraben 4, CH 4031, Basel, Switzerland
    BMC Infect Dis 7:10. 2007
    ..This study aims to evaluate the diagnostic and prognostic accuracy of clinical signs and symptoms and laboratory biomarkers for CAP...
  23. pmc Influenza virus neuraminidase contributes to secondary bacterial pneumonia
    Ville T Peltola
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    J Infect Dis 192:249-57. 2005
    Secondary bacterial pneumonia is a common cause of death during influenza epidemics. We hypothesized that virus-specific factors could contribute to differences in annual excess mortality...
  24. ncbi Associations between periodontal disease and risk for nosocomial bacterial pneumonia and chronic obstructive pulmonary disease. A systematic review
    Frank A Scannapieco
    Department of Oral Biology, School of Dental Medicine, University at Buffalo, State University of New York, Buffalo, New York, USA
    Ann Periodontol 8:54-69. 2003
    ..Several recent studies provide evidence that the oral cavity may influence the initiation and/or the progression of lung diseases such as pneumonia and chronic obstructive pulmonary disease (COPD)...
  25. pmc Automatic detection of acute bacterial pneumonia from chest X-ray reports
    M Fiszman
    The University of Utah, Salt Lake City, Utah, USA
    J Am Med Inform Assoc 7:593-604. 2000
    ..To evaluate the performance of a natural language processing system in extracting pneumonia-related concepts from chest x-ray reports...
  26. ncbi Inadequate antimicrobial treatment: an important determinant of outcome for hospitalized patients
    M H Kollef
    Department of Internal Medicine, Pulmonary and Critical Care Division, Washington University School of Medicine, St Louis, MO 63110, USA
    Clin Infect Dis 31:S131-8. 2000
    ..Further study evaluating the use of antibiotic practice guidelines and strategies to reduce inadequate treatment is necessary to determine their impact on patient outcomes...
  27. ncbi The influence of age and gender on the population-based incidence of community-acquired pneumonia caused by different microbial pathogens
    Felix Gutierrez
    Infectious Diseases Unit, Internal Medicine Department, Hospital General Universitario de Elche, Camí de la Almazara S N, 03203 Elche, Alicante, Spain
    J Infect 53:166-74. 2006
    ..To determine the population-based incidence of community-acquired pneumonia (CAP) in adults and to assess the relative importance of age and gender on the incidence of infections caused by different microbial pathogens...
  28. ncbi Outpatient care compared with hospitalization for community-acquired pneumonia: a randomized trial in low-risk patients
    Jordi Carratala
    IDIBELL Hospital Universitari de Bellvitge, University of Barcelona, and SCIAS Hospital de Barcelona, Barcelona, Spain
    Ann Intern Med 142:165-72. 2005
    ..The Pneumonia Severity Index (PSI) has been advocated as an objective measure of risk stratification to help determine the initial site of treatment for patients with community-acquired pneumonia...
  29. ncbi Bacterial pneumonia in HIV-infected patients: use of the pneumonia severity index and impact of current management on incidence, aetiology and outcome
    A Curran
    Infectious Diseases Department, Hospital Universitari Vall d Hebron, Autonomous University of Barcelona, P1 Valld Hebron, Barcelona, Spain
    HIV Med 9:609-15. 2008
    Despite a recent decrease, bacterial pneumonia (BP) is still the most common admission diagnosis in HIV patients. We analyse BP incidence, characteristics and prevention measures.
  30. ncbi Atypical pathogens in adult patients admitted with community-acquired pneumonia in Korea
    Seung Joon Lee
    Department of Internal Medicine, College of Medicine, Kangwon National University, Chunchon 200 701, Korea
    Jpn J Infect Dis 55:157-9. 2002
    ..In conclusion, of the atypical pathogens causing CAP, C. pneumoniae and M. pneumoniae appear to be the important etiologic pathogens in Korea...
  31. ncbi TLR9 is required for protective innate immunity in Gram-negative bacterial pneumonia: role of dendritic cells
    Urvashi Bhan
    Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan Medical Center, Ann Arbor, MI 48109, USA
    J Immunol 179:3937-46. 2007
    ....
  32. ncbi Leukotriene-deficient mice manifest enhanced lethality from Klebsiella pneumonia in association with decreased alveolar macrophage phagocytic and bactericidal activities
    M B Bailie
    Division of Pulmonary and Critical Care Medicine, University of Michigan Medical Center, Ann Arbor 48109, USA
    J Immunol 157:5221-4. 1996
    ..We conclude that endogenous LTs play a critical role in the defense against bacterial pneumonia in this murine model.
  33. ncbi Effect of Pseudomonas infection on weight loss, lung mechanics, and cytokines in mice
    A M van Heeckeren
    Departments of Pediatrics, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106 4948, USA
    Am J Respir Crit Care Med 161:271-9. 2000
    ..aeruginosa-infected mice was associated with the inflammatory process and not with altered pulmonary responsiveness. These findings may provide insights into the cause of cachexia and weight loss seen in patients with CF...
  34. ncbi Risk factors and clinical characteristics associated with hospitalization for community-acquired bacterial pneumonia in HIV-positive patients according to the presence of liver cirrhosis
    D Manno
    Dept of Infectious and Tropical Diseases, University of Brescia, Piazzale Spedali Civili 1, Brescia, Italy
    Infection 37:334-9. 2009
    Community-acquired bacterial pneumonia (CABP) represents an important cause of morbidity and mortality for cirrhotic and HIV-infected patients, respectively. However, little is known on CABP in HIV-positive patients with cirrhosis...
  35. ncbi Understanding the inflammatory cytokine response in pneumonia and sepsis: results of the Genetic and Inflammatory Markers of Sepsis (GenIMS) Study
    John A Kellum
    Department of Critical Care Medicine, University of Pittsburgh School of Medicine, 604 Scaife Hall, 3550 Terrace St, Pittsburgh, PA15261, USA
    Arch Intern Med 167:1655-63. 2007
    ..In this study we describe the systemic cytokine response to pneumonia and determine if specific patterns, including the balance of proinflammatory and anti-inflammatory markers, are associated with severe sepsis and death...
  36. ncbi Bacterial pneumonia in the AIDS patients
    A K Salami
    Department of Medicine, Faculty of Health Sciences, University of Ilorin P M B 1515, Ilorin, Nigeria
    West Afr J Med 25:1-5. 2006
    To determine the incidence, microbiological pattern and prognostic factor of bacterial pneumonia in AIDS patients.
  37. ncbi Epidemiology and outcomes of health-care-associated pneumonia: results from a large US database of culture-positive pneumonia
    Marin H Kollef
    Washington University School of Medicine, 660 South Euclid Ave, St Louis, MO 63110, USA
    Chest 128:3854-62. 2005
    ..Accumulating evidence suggests that health-care-associated infections are distinct from those that are truly community acquired...
  38. ncbi Resolution of ventilator-associated pneumonia: prospective evaluation of the clinical pulmonary infection score as an early clinical predictor of outcome
    Carlos M Luna
    Pulmonary and Critical Care Divisions, Department of Medicine, Hospital de Clinicas Jose de San Martin, Universidad de Buenos Aires, Argentina
    Crit Care Med 31:676-82. 2003
    ..To prospectively evaluate the performance of the Clinical Pulmonary Infection Score (CPIS) and its components to identify early in the hospital course of ventilator-associated pneumonia (VAP) which patients are responding to therapy...
  39. ncbi The innate immune rheostat: influence on lung inflammatory disease and secondary bacterial pneumonia
    Tracy Hussell
    Imperial College London, Leukocyte Biology Section, National Heart and Lung Institute, London SW7 2AZ, UK
    Biochem Soc Trans 37:811-3. 2009
    ..In the extreme, this leads to bacterial pneumonia, sepsis and death...
  40. ncbi Hospitalists and improved cost savings in patients with bacterial pneumonia at a state level
    Danielle B Scheurer
    Department of Internal Medicine, Hospitalist Program, Medical University of South Carolina, Charleston, SC 29425, USA
    South Med J 98:607-10. 2005
    ..In the hospitalist literature, most studies have focused on outcomes related to cost savings for individual hospital systems. This study sought to determine if hospitalists could improve cost savings at a state level...
  41. pmc Methicillin-resistant-Staphylococcus aureus hospitalizations, United States
    Matthew J Kuehnert
    Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Emerg Infect Dis 11:868-72. 2005
    ..95 per 1,000 hospital discharges. The method used in our analysis may provide a simple way to assess trends of the magnitude of MRSA infection nationally...
  42. ncbi Development of a multiplex real-time quantitative PCR assay to detect Chlamydia pneumoniae, Legionella pneumophila and Mycoplasma pneumoniae in respiratory tract secretions
    Martine Welti
    Institute of Microbiology, University Hospital of Lausanne, Lausanne, Switzerland
    Diagn Microbiol Infect Dis 45:85-95. 2003
    ..Of 19 serology-positive patients, 14 were confirmed by the multiplex real-time PCR to be infected by either one of the three pathogens. All samples from serology-negative patients were negative with the multiplex real-time PCR...
  43. ncbi Epidemiological survey on incidence and treatment of community acquired pneumonia in Italy
    Giovanni Viegi
    Pulmonary Environmental Epidemiology Unit, CNR Institute of Clinical Physiology, Pisa, Italy
    Respir Med 100:46-55. 2006
    ..To estimate annual incidence of community acquired pneumonia (CAP) in an Italian general population sample...
  44. pmc Differentiation of bacterial and viral pneumonia in children
    R Virkki
    Department of Diagnostic Imaging, Turku University Hospital, Kiinamyllynkatu 4 8, 20520 Turku, Finland
    Thorax 57:438-41. 2002
    ....
  45. pmc Severe community-acquired pneumonia due to Staphylococcus aureus, 2003-04 influenza season
    Jeffrey C Hageman
    Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Emerg Infect Dis 12:894-9. 2006
    ..In communities with a high prevalence of MRSA, empiric therapy of severe CAP during periods of high influenza activity should include consideration for MRSA...
  46. ncbi Incidence and risk factors of bacterial pneumonia requiring hospitalization in HIV-infected patients started on a protease inhibitor-containing regimen
    V Le Moing
    Infectious and Tropical Diseases Department, Hopital Gui de Chauliac, Montpellier, France
    HIV Med 7:261-7. 2006
    To describe the incidence and risk factors of bacterial pneumonia occurring in patients treated with antiretrovirals.
  47. ncbi Mixed community-acquired pneumonia in hospitalised patients
    A de Roux
    Servei de Pneumologia i Allergia Respiratoria, Institut Clinic del Torax, Facultad de Medicina, Universitat de Barcelona, and Servei de Malalties Infeccioses, Hospital Clinic i Provincial de Barcelona, Spain
    Eur Respir J 27:795-800. 2006
    ..In conclusion, mixed pneumonia occurs in >10% of cases with community-acquired pneumonia requiring hospitalisation...
  48. ncbi Pneumonic vs nonpneumonic acute exacerbations of COPD
    David Lieberman
    Pulmonary Unit, Division of Internal Medicine, Soroka University Medical Center, The Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel 84101
    Chest 122:1264-70. 2002
    ..To describe and compare the background, clinical manifestations, disease course, and infectious etiologies of pneumonic acute exacerbations (PNAE) vs nonpneumonic acute exacerbations (NPAE) of COPD...
  49. pmc Establishment of lethal inhalational infection with Francisella tularensis (tularaemia) in the common marmoset (Callithrix jacchus)
    Michelle Nelson
    Biomedical Sciences, Defence Science and Technology Laboratory Dstl, Porton Down, Salisbury, Wiltshire, UK
    Int J Exp Pathol 90:109-18. 2009
    ..The common marmoset may therefore be considered a suitable model for further studies of inhalational tularaemia...
  50. ncbi Radiologic progression of pulmonary infiltrates predicts a worse prognosis in severe community-acquired pneumonia than bacteremia
    Thiago Lisboa
    Critical Care Department, Joan XXIII University Hospital, CIBER Enfermedades Respiratorias, Carrer Mallafre Guasch, Tarragona, Spain
    Chest 135:165-72. 2009
    ..The objective of this study was to investigate the relative importance of these two factors in the outcome of patients with severe CAP (sCAP)...
  51. pmc Pneumonia in HIV-infected persons: increased risk with cigarette smoking and treatment interruption
    Fred M Gordin
    Infectious Diseases 151B, Veterans Affairs Medical Center, 50 Irving Street, NW, Washington, DC 20422, USA
    Am J Respir Crit Care Med 178:630-6. 2008
    b>Bacterial pneumonia is a major cause of morbidity for HIV-infected persons and contributes to excess mortality in this population.
  52. ncbi Diagnosis of ventilator-associated pneumonia: agreement between quantitative cultures of endotracheal aspiration and plugged telescoping catheter
    Souheil Elatrous
    Intensive Care Unit, centre hospitalo universitaire F Bourguiba, 5000 Monastir, Tunisia
    Intensive Care Med 30:853-8. 2004
    ..To evaluate the diagnostic agreement between quantitative cultures of samples obtained with endotracheal aspiration (ETA) and plugged telescoping catheter (PTC)...
  53. ncbi Alveolar macrophages that phagocytose apoptotic neutrophils produce hepatocyte growth factor during bacterial pneumonia in mice
    K Morimoto
    Department of Respiratory Medicine, Nijigaoka Hospital, Nagasaki, Japan
    Am J Respir Cell Mol Biol 24:608-15. 2001
    ..To evaluate the role of HGF in bacterial pneumonia, the kinetics of HGF production and the cellular sources of HGF have been examined in the lungs of mice ..
  54. ncbi Markers of treatment failure in hospitalised community acquired pneumonia
    R Menendez
    Servicio de Neumologia, Hospital Universitario La Fe, Avda de Campanar 21, 46009 Valencia, Spain
    Thorax 63:447-52. 2008
    ..We evaluated the systemic cytokine profile (tumour necrosis factor alpha, interleukin (IL)1, IL6, IL8 and IL10), C reactive protein (CRP) and procalcitonin (PCT) in patients with CAP who had treatment failure...
  55. ncbi Contribution of blinded, protected quantitative specimens to the diagnostic and therapeutic management of ventilator-associated pneumonia
    Christian Brun-Buisson
    Service de Reanimation Medicale, Hopital Henri Mondor, Assistance Publique Hopitaux de Paris, 51, avenue du Mal de Lattre de Tassigny, 94010 Creteil Cedex, France
    Chest 128:533-44. 2005
    ..Sampling techniques for microbiological diagnosis of ventilator-associated pneumonia (VAP) remain debated, and it is unclear to what extent invasive diagnostic techniques impact the management of patients...
  56. pmc Bacterial pneumonia among HIV-infected patients: decreased risk after tobacco smoking cessation. ANRS CO3 Aquitaine Cohort, 2000-2007
    Antoine Benard
    INSERM, U897, CIC EC7, Bordeaux, France
    PLoS ONE 5:e8896. 2010
    b>Bacterial pneumonia is still a substantial cause of morbidity and mortality in HIV-infected patients in the era of combination Antiretroviral Therapy...
  57. ncbi Complications of seasonal and pandemic influenza
    Michael B Rothberg
    Division of General Medicine, Department of Medicine, Baystate Medical Center, Springfield, MA, USA
    Crit Care Med 38:e91-7. 2010
    ..Staphylococcus aureus, including methicillin-resistant strains, is an important cause of secondary bacterial pneumonia with a high mortality rate. Treatment of pneumonia should include empirical coverage for this pathogen...
  58. ncbi Hospital-acquired pneumonia: risk factors, microbiology, and treatment
    J P Lynch
    Division of Pulmonary and Critical Care Medicine, University of Michigan Medical Center, 3916 Tubman Center, Ann Arbor, MI 48109, USA
    Chest 119:373S-384S. 2001
    ..For pseudomonal HAP, we advise combination therapy with an antipseudomonal beta-lactam plus an aminoglycoside or a fluoroquinolone (eg, ciprofloxacin)...
  59. ncbi Acute bacterial pneumonia is associated with the occurrence of acute coronary syndromes
    Vicente F Corrales-Medina
    Department of Medicine, Baylor College of Medicine, Houston, Texas, USA vfmedina bcm edu
    Medicine (Baltimore) 88:154-9. 2009
    ..cohort and self-controlled case series analyses to define the closeness of the association between acute bacterial pneumonia due to Streptococcus pneumoniae or Haemophilus influenzae and ACS...
  60. pmc Identification of Klebsiella pneumoniae genes uniquely expressed in a strain virulent using a murine model of bacterial pneumonia
    Helen Y Lau
    Department of Microbiology and Immunology, University of Michigan, Ann Arbor, MI 48109, USA
    Microb Pathog 42:148-55. 2007
    ....
  61. ncbi Staphylococcus aureus community-acquired pneumonia during the 2006 to 2007 influenza season
    Alexander J Kallen
    Division of Healthcare Quality Promotion, National Center for Preparedness, Detection and Control of Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA
    Ann Emerg Med 53:358-65. 2009
    ..In response to a number of cases reported to public health authorities in early 2007, additional case reports were solicited nationwide to better define S. aureus community-acquired pneumonia during the 2006 to 2007 influenza season...
  62. pmc Comparison of oral amoxicillin and intravenous benzyl penicillin for community acquired pneumonia in children (PIVOT trial): a multicentre pragmatic randomised controlled equivalence trial
    Maria Atkinson
    Division of Child Health, University of Nottingham, University Hospital Queen s Medical Centre, Nottingham, UK
    Thorax 62:1102-6. 2007
    ..To ascertain whether therapeutic equivalence exists for the treatment of paediatric community acquired pneumonia by the oral and intravenous (IV) routes...
  63. ncbi Bacterial pneumonia: comparison between diabetics and non-diabetics
    D H Akbar
    Department of Medicine, King Abdulaziz University Hospital, Jeddah, Kingdom of Saudi Arabia
    Acta Diabetol 38:77-82. 2001
    ..No significant difference in mortality was found between diabetics and non-diabetics, for either CAP or HAP...
  64. ncbi Prior statin therapy is associated with a decreased rate of severe sepsis
    Yaniv Almog
    Medical Intensive Care Unit, Soroka University Medical Center, Faculty of Health Sciences, Ben Gurion University, Beer Sheva, Israel
    Circulation 110:880-5. 2004
    ..The aim of this study was to determine whether patients treated with statins develop severe sepsis less frequently...
  65. ncbi Clinical predictors of occult pneumonia in the febrile child
    Charles G Murphy
    Division of Emergency Medicine, Children s Hospital Boston, Harvard Medical School, Boston, MA, USA
    Acad Emerg Med 14:243-9. 2007
    ....
  66. ncbi Macrophages, CD4+ or CD8+ cells are each sufficient for protection against Chlamydia pneumoniae infection through their ability to secrete IFN-gamma
    Antonio Gigliotti Rothfuchs
    Microbiology and Tumorbiology Center, Karolinska Institute, Stockholm, Sweden
    J Immunol 172:2407-15. 2004
    ..pneumoniae. IFN-gamma secreted by nonlymphoid cells was not required for T cell-mediated protection against C. pneumoniae; however, IFN-gamma regulated T cell protective functions...
  67. ncbi Pulmonary tuberculosis presenting as community-acquired pneumonia
    Chong Kin Liam
    Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
    Respirology 11:786-92. 2006
    ....
  68. ncbi Serum procalcitonin concentrations in bacterial pneumonia in children: a negative result in primary healthcare settings
    Matti Korppi
    Department of Paediatrics, Kuopio University Hospital, Kuopio University, Kuopio, Finland
    Pediatr Pulmonol 35:56-61. 2003
    ..viral infection). We conclude that serum PCT measurements have no role in the diagnosis of bacterial CAP in children in primary healthcare settings...
  69. pmc Interleukin-18 impairs the pulmonary host response to Pseudomonas aeruginosa
    Marc J Schultz
    Laboratory of Experimental Internal Medicine, Department of Intensive Care Medicine, C3 326, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Infect Immun 71:1630-4. 2003
    ..These results demonstrate that the presence of endogenous IL-18 activity facilitates inflammatory responses in the lung during Pseudomonas pneumonia, concurrently impairing bacterial clearance...
  70. ncbi Acid aspiration induces bacterial pneumonia by enhanced bacterial adherence in mice
    Hiroaki Mitsushima
    Department of Internal Medicine, Nagasaki University, 1 12 4 Sakamoto, Nagasaki, 852 8523, Japan
    Microb Pathog 33:203-10. 2002
    The issue of whether acid aspiration facilitates bacterial pneumonia caused by Pseudomonas aeruginosa by enhanced bacterial adherence was examined in mice...
  71. pmc Intrapulmonary expression of macrophage inflammatory protein 1alpha (CCL3) induces neutrophil and NK cell accumulation and stimulates innate immunity in murine bacterial pneumonia
    Xianying Zeng
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, The University of Michigan Medical School, Ann Arbor, Michigan 48109 0360, USA
    Infect Immun 71:1306-15. 2003
    ..Furthermore, the transgenic expression of MIP-1alpha during bacterial pneumonia resulted in enhanced expression of gamma interferon mRNA, compared to that observed in Klebsiella-..
  72. ncbi Moxifloxacin monotherapy compared to amoxicillin-clavulanate plus roxithromycin for nonsevere community-acquired pneumonia in adults with risk factors
    H Portier
    CHU de Dijon, Hopital du Bocage, BP 1542, 21034 Dijon Cedex, France
    Eur J Clin Microbiol Infect Dis 24:367-76. 2005
    ..4% and 21.1%. On the basis of these results, once-daily oral moxifloxacin alone is as effective as amoxicillin-clavulanate plus roxithromycin for the treatment of CAP in patients with risk factors...
  73. ncbi Total extracellular surfactant is increased but abnormal in a rat model of gram-negative bacterial pneumonia
    Thomas A Russo
    Department of Medicine, State University of New York at Buffalo, Buffalo 14214, USA
    Am J Physiol Lung Cell Mol Physiol 283:L655-63. 2002
    ..In vitro surface cycling studies with calf lung surfactant extract suggested that bacterially derived factors may have contributed in part to the surfactant alterations seen in vivo...
  74. ncbi Serum vascular endothelial growth factor is elevated in cystic fibrosis and decreases with treatment of acute pulmonary exacerbation
    S A McColley
    Department of Pediatrics, Northwestern University Medical School, Chicago, Illinois, USA
    Am J Respir Crit Care Med 161:1877-80. 2000
    ..We speculate that increased circulating VEGF is related to chronic inflammation, which is robust in CF. Elevated circulating VEGF may result in tissue angiogenesis, furthering the progression of pulmonary disease...
  75. ncbi Community acquired bacterial pneumonia
    Stavros Anevlavis
    Department of Pneumonology, University Hospital of Alexandroupolis, Democritus University of Thrace, Medical School, Alexandroupolis 68100, Greece
    Expert Opin Pharmacother 11:361-74. 2010
    ..Among infectious diseases, CAP is the leading cause of death in the world and is associated with a substantial economic burden to health are systems around the globe...
  76. ncbi A Comparison of group A Streptococcus versus Streptococcus pneumoniae pneumonia
    Nawal Al-Kaabi
    Chalmers Research Group, Statistical Division, Children s Hospital of Eastern Ontario, Ottawa, Ontario, Canada
    Pediatr Infect Dis J 25:1008-12. 2006
    ..St reptococcus pyogenes is an uncommon cause of community-acquired pneumonia in children. Further, its clinical course in comparison to pneumonia caused by Streptococcus pneumonia has not been previously highlighted...
  77. ncbi Accuracy of delayed cultures of plugged telescoping catheter samples for diagnosing bacterial pneumonia
    A De Lassence
    Service de Reanimation Medicale, Hopital Louis Mourier, Colombes, France
    Crit Care Med 29:1311-7. 2001
    ..We have evaluated the effect of delaying the culture of immediate plugged telescoping catheter (PTC) samples performed before starting antibiotherapy...
  78. ncbi Murine models of chronic Pseudomonas aeruginosa lung infection
    Anna M van Heeckeren
    Department of Pediatrics, Rainbow Babies and Childrens Hospital, Case Western Reserve University School of Medicine, 2109 Adelbert Road, Cleveland, OH 44106 4948, USA
    Lab Anim 36:291-312. 2002
    ..aeruginosa-laden agarose beads, since the histopathological features were similar, though further characterization is needed to evaluate its utility as an adequate model of cystic fibrosis...
  79. ncbi Diagnostic test for etiologic agents of community-acquired pneumonia
    John G Bartlett
    Division of Infectious Diseases, Department of Medicine, Johns Hopkins University School of Medicine, Johns Hopkins Hospital, 600 North Wolfe Street, Baltimore, MD 21205 2191, USA
    Infect Dis Clin North Am 18:809-27. 2004
    ..New tests that merit use in selected patients are the urinary antigen assay for S pneumoniae and the PCR test for L pneumophila. Anticipated developments in the near future are PCR tests for detection of C pneumoniae and M pneumoniae...
  80. ncbi The burden of community-acquired pneumonia in seniors: results of a population-based study
    Michael L Jackson
    Center for Health Studies, Group Health Cooperative, University of Washington, Seattle, USA
    Clin Infect Dis 39:1642-50. 2004
    ....
  81. ncbi Disease severity in patients with simultaneous influenza and bacterial pneumonia
    Masafumi Seki
    Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences
    Intern Med 46:953-8. 2007
    To determine the differences in the clinical features of bacterial pneumonia patients between patients co-infected with influenza virus or not co-infected.
  82. pmc Use of dynamic microsimulation to predict disease progression in patients with pneumonia-related sepsis
    Gorkem Saka
    Department of Industrial Engineering, University of Pittsburgh, 3700 Ohara St, 3700 Benedum Hall, Pittsburgh, PA 15261, USA
    Crit Care 11:R65. 2007
    ....
  83. ncbi Gram-negative bacterial pneumonia: aetiology and management
    Despoina Koulenti
    Critical Care Department, Joan XXIII University Hospital, University Rovira y Virgili Institut PereVirgili, Tarragona, Spain
    Curr Opin Pulm Med 12:198-204. 2006
    ..Recent articles of clinical and investigational interest on Gram-negative pneumonia, particularly hospital-acquired and ventilator-associated pneumonia, are reviewed...
  84. ncbi Etiology of severe pneumonia in the very elderly
    A A El-Solh
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, Erie County Medical Center and Kaleida Health Care System, University at Buffalo School of Medicine and Biomedical Sciences, Buffalo, New York 14215, USA
    Am J Respir Crit Care Med 163:645-51. 2001
    ..7; 95% CI, 1.8 to 15.6; p = 0.02), and inadequate antimicrobial therapy (OR, 2.6; 95% CI, 1.4 to 23.9; p = 0.034). Further studies should focus on identifying effective antimicrobial regimens in randomized trials...
  85. ncbi Community-acquired pneumonia in Christchurch and Waikato 1999-2000: microbiology and epidemiology
    R Laing
    Canterbury Respiratory Research Group, Christchurch School of Medicine and Health Sciences, University of Otago
    N Z Med J 114:488-92. 2001
    ..Ongoing surveillance of antibiotic resistance and variations in the prevalence of organisms causing community-acquired pneumonia is required to guide clinicians' empiric antibiotic use...
  86. ncbi Computed tomography for the diagnosis and treatment monitoring of bacterial pneumonia in Indian pythons (Python molurus)
    M Pees
    Clinic for Birds and Reptiles, University of Leipzig, An den Tierkliniken, 04103 Leipzig, Germany
    Vet Rec 163:152-6. 2008
    ..Except for one python with only mild clinical signs, the attenuation after successful treatment was still higher than in healthy pythons...
  87. ncbi Aetiology of community-acquired pneumonia: serological results of a paediatric survey
    Massimiliano Don
    Department of Paediatrics, School of Medicine DPMSC, University of Udine, Udine, Italy
    Scand J Infect Dis 37:806-12. 2005
    ..pneumoniae at >2 y of age and emphasize the emerging role of hMPV. The high proportion of mixed viral-bacterial infections highlights the need to treat all children with CAP with antibiotics...
  88. ncbi Severe community-acquired pneumonia
    Santiago Ewig
    Medizinische Universitäts Poliklinik, Bonn, Germany
    Curr Opin Crit Care 8:453-60. 2002
    ....
  89. ncbi Community-acquired pneumonia due to gram-negative bacteria and pseudomonas aeruginosa: incidence, risk, and prognosis
    Francisco Arancibia
    Hospital Clinic i Provincial, Servei de Pneumologia i Allergia Respiratoria, Villarroel, 170, E 08036 Barcelona, Spain
    Arch Intern Med 162:1849-58. 2002
    ..We determined the incidence of, prognosis of, and risk factors for CAP due to gram-negative bacteria (GNB), including Pseudomonas aeruginosa...
  90. pmc Detection of Pneumocystis DNA in samples from patients suspected of bacterial pneumonia--a case-control study
    Jannik Helweg-Larsen
    Copenhagen HIV Programme, Department of Infectious Diseases, Copenhagen, Denmark
    BMC Infect Dis 2:28. 2002
    ..To investigate the clinical importance of a positive Pneumocystis-PCR among HIV-uninfected patients suspected of bacterial pneumonia, a retrospective matched case-control study was conducted.
  91. ncbi HIV infection and chronic chest disease as risk factors for bacterial pneumonia: a case-control study
    Salome Charalambous
    Aurum Health Research, Welkom, South Africa
    AIDS 17:1531-7. 2003
    ..To investigate risk factors for severe acute pneumonia in South African gold miners...
  92. pmc Improving therapeutic strategies for secondary bacterial pneumonia following influenza
    Jonathan A McCullers
    Department of Infectious Diseases, St Jude Children s Research Hospital, 332 N Lauderdale St, Memphis, TN 38105 2794, USA
    Future Microbiol 3:397-404. 2008
    Secondary bacterial pneumonia following influenza is an old problem, which is re-emerging. Despite rapid advances in our armamentarium of antimicrobials, the case-fatality rate for this frequent complication of influenza remains high...
  93. ncbi Chlamydophila (Chlamydia) pneumoniae induces histidine decarboxylase production in the mouse lung
    Katalin Burian
    Department of Medical Microbiology and Immunobiology, University of Szeged, Szeged, Hungary
    Immunol Lett 89:229-36. 2003
    ..These results point to a strong association between local histamine production and other inflammatory mediators and are novel in demonstrating the role of histamine in the pathomechanism of C. pneumoniae infections...
  94. ncbi Impact of bacterial pneumonia and Pneumocystis carinii pneumonia on human immunodeficiency virus disease progression. Pulmonary Complications of HIV Study Group
    D H Osmond
    San Francisco General Hospital, California, USA
    Clin Infect Dis 29:536-43. 1999
    ..The median duration of survival among 150 individuals following initial bacterial pneumonia was 24 months, compared with 37 months among 299 human immunodeficiency virus (HIV)-infected control ..
  95. ncbi Tsunami lung: a necrotising pneumonia in survivors of the Asian tsunami
    Anthony M Allworth
    Med J Aust 182:364. 2005
  96. ncbi Aetiology and clinical presentation of mild community-acquired bacterial pneumonia
    B Beovic
    Department of Infectious Diseases, University Medical Centre Ljubljana, Japljeva 2, 1525 Ljubljana, Slovenia
    Eur J Clin Microbiol Infect Dis 22:584-91. 2003
    ..Patients with atypical aetiology of pneumonia differed from those with typical bacterial pneumonia or pneumonia of unknown aetiology in age, presence of dyspnea, and bronchial breathing on lung auscultation...
  97. ncbi Multiplexed serology in atypical bacterial pneumonia
    Frédérique Gouriet
    Faculte de Medecine, 27 Boulevard Jean Moulin, 13385 Marseille, France
    Ann N Y Acad Sci 1078:530-40. 2006
    ..This should prove to be a valuable tool for the rapid determination of patient status, allowing effective and efficient postexposure prophylaxis and treatment...
  98. ncbi The attributable morbidity and mortality of ventilator-associated pneumonia in the critically ill patient. The Canadian Critical Trials Group
    D K Heyland
    Department of Medicine, Queen s University, Kingston, ON, Canada
    Am J Respir Crit Care Med 159:1249-56. 1999
    ..We conclude that VAP prolongs ICU length of stay and may increase the risk of death in critically ill patients. The attributable risk of VAP appears to vary with patient population and infecting organism...
  99. ncbi Differential patterns of apoptosis in resolving and nonresolving bacterial pneumonia
    J A Kazzaz
    CardioPulmonary Research Institute, Mineola, NY 11501, USA
    Am J Respir Crit Care Med 161:2043-50. 2000
    ..These data indicate that the location and timing of apoptosis may determine whether pneumonia resolves or progresses to fibrosis...
  100. ncbi Antimicrobial resistance in Streptococcus pneumoniae: implications for patients with community-acquired pneumonia
    C E Chenoweth
    Department of Internal Medicine, University of Michigan Health System, Ann Arbor 48109 0378, USA
    Mayo Clin Proc 75:1161-8. 2000
    ..In this article, we provide an overview of the development of S pneumoniae resistance to commonly used antibiotics and discuss the implications of the development of resistance on treatment decisions...
  101. ncbi Impact of fluoroquinolones on the diagnosis of pulmonary tuberculosis initially treated as bacterial pneumonia
    Y S Yoon
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University College of Medicine, Republic of Korea
    Int J Tuberc Lung Dis 9:1215-9. 2005
    ..The aim of this study was to assess the effect of empiric fluoroquinolone therapy on delays in diagnosis in patients with PTB initially misdiagnosed as bacterial pneumonia.

Research Grants64

  1. Epidemiology and Etiology of Hospitalized Pneumonia in Children
    Krow Ampofo; Fiscal Year: 2010
    ..Salt Lake County, including primary viral pneumonia, viral and bacterial co-infection, and post-influenza bacterial pneumonia. Specific Aim 3: Document the etiology of pediatric pneumonia due to established and emerging pathogens ..
  2. Analogs of GTP as novel inhibitors of bacterial c-di-GMP-synthesizing enzymes
    George E Wright; Fiscal Year: 2010
    ..strains that resist conventional antibiotics and are associated with numerous infectious diseases such as bacterial pneumonia, stent blockage, catheter colonization, etc...
  3. Pulmonary Defenses Against Intracellular Infection
    Shawn J Skerrett; Fiscal Year: 2013
    ..Legionella pneumophila (Lp) is an important cause of bacterial pneumonia and an intracellular pathogen of alveolar macrophages (AM)...
  4. MIF AND THE HOST RESPONSE TO INFECTION
    RICHARD J BUCALA; Fiscal Year: 2013
    ..hope to show how genetic variation in MIF influences the host response to particular infections, including bacterial pneumonia and influenza...
  5. Mechanisms of adaptive immunity to P. aeruginosa in the lung
    Gregory P Priebe; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: The proposed studies investigate how vaccines prevent bacterial pneumonia. In mouse models of acute pneumonia, we focus on a type of helper T cell that makes the cytokine IL-17, ..
  6. Mechanisms of Pleural Fibrosis in Empyema
    Kamal A Mohammed; Fiscal Year: 2013
    ..knock out mouse model because defective HO-1 expression was associated with increased susceptibility to bacterial pneumonia in an older population3...
  7. Otitis media-associated pneumococcal genes
    Honggao Yan; Fiscal Year: 2013
    ..RELEVANCE: The bacterium Streptococcus pneumoniae is a major causative agent of middle ear infection, bacterial pneumonia, blood infection, and meningitis...
  8. Chicago Community-Acquired Pneumonia Consortium
    Richard G Wunderink; Fiscal Year: 2010
    ..The role of influenza in bacterial pneumonia, especially pneumococcal and CA-MRSA, will be aggressively explored with PCR, culture, and paired serology...
  9. Neutrophil Accumulation in Bacterial Pneumonia
    Samithamby Jeyaseelan; Fiscal Year: 2013
    ..Our preliminary data demonstrate that (1) human lungs with bacterial pneumonia show higher expression of NLR family pyrin domain containing 6 (NLRP6) inflammasome;(2) neutrophils show ..
  10. Influenza therapy by Au-nanorod 5'PPP-NS1-siRNA/cDNA targeting of bronchial cells
    Paul R Knight; Fiscal Year: 2010
    ..severity of symptoms of influenza including the highly pathogenic H5N1 "bird flu" and the risk of secondary bacterial pneumonia, which is the major cause of death secondary to influenza...
  11. Elucidating the A. baumannii response to calprotectin-mediated zinc starvation
    BRITTANY MORTENSEN; Fiscal Year: 2013
    ..Together these studies will improve our understanding of host nutritional immunity during bacterial pneumonia and define how A. baumannii subverts this host defense to cause disease...
  12. Longitudinal Studies of HIV-Associated Bacterial Pneumonia
    William N Rom; Fiscal Year: 2013
    ..Pulmonary infectious complications are still recognized: bacterial pneumonia, tuberculosis, CMV and PCP...
  13. Counter-Regulatory Lipid Mediators in Lung Disease
    Bruce D Levy; Fiscal Year: 2012
    ..Despite a robust inflammatory response, bacterial pneumonia is a frequent complication...
  14. Gram-Negative Pneumonia and Lipopolysaccharide Binding Protein
    MARK RICHARD HEMMILA; Fiscal Year: 2010
    ..The research project will focus on the pathogenesis of Gram-negative bacterial pneumonia, specifically with respect to the role of lipopolysaccharide binding protein (LBP)...
  15. Interactions of smoking, PD-1 and IL-10 in HIV-associated lung disease
    Brent E Palmer; Fiscal Year: 2013
    ..of HIV-1/AIDS continue to be a major cause of morbidity and mortality in HIV-1-infected patients, with bacterial pneumonia and chronic obstructive pulmonary disease (COPD) being the most commonly identified pulmonary diseases...
  16. Th17 Cytokines and Lung Immunity
    Jay K Kolls; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Bacterial pneumonia is an important clinical problem and host defense mechanisms against pneumonia are not fully understood...
  17. Treatment of bacterial pneumonia after influenza
    Jonathan A McCullers; Fiscal Year: 2010
    ..b>Bacterial pneumonia after influenza infection typically presents at a more advanced stage, has complex features including multi-..
  18. Plasma Gelsolin and Host Defense After Lung Injury
    Lester Kobzik; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Bacterial pneumonia is a frequent complication of acute lung injury...
  19. Protective activity of the lectin-like domain of TNF in permeability edema
    Rudolf Lucas; Fiscal Year: 2013
    ..of this research program can thus provide important information about mechanisms leading to permeability edema and dysfunctional ALC during bacterial pneumonia and can thus lead to the identification of novel therapeutic strategies.
  20. Influenza A Inhibits TH17 Host Defense Against Bacterial Pneumonia
    John F Alcorn; Fiscal Year: 2013
    ..aureus challenge our group has found that Influenza A exacerbates secondary bacterial pneumonia. We have shown that the mechanism is likely mediated by type I Interferon suppression of IL-23 production ..
  21. Cardiolipin, pneumonia, and a novel cardiolipin pump
    Rama K Mallampalli; Fiscal Year: 2013
    ..Sepsis due to bacterial pneumonia from virulent pathogens such as H. influenzae is the most common cause of ALI/ARDS...
  22. Inhaled aerosols for prevention and treatment of respiratory infections
    Robert W Clarke; Fiscal Year: 2013
    ..to: reduce exhaled bioaerosols in humans;arrest transmission of and treat porcine influenza;treat murine bacterial pneumonia;and alter the rheological properties of mucus mimetics, suggesting that additional aerosol therapies may be ..
  23. Targeting a leukocyte disintegrin metalloprotease during bacterial pneumonia
    Bruce K Walcheck; Fiscal Year: 2013
    ..The impact of these studies is that they will critically advance our understanding of the mechanisms of action of ADAM17 during lung infection, as well as indicate the therapeutic potential of this immune regulator. ..
  24. Role of Mkp-1 in pneumonia
    LYN MILLER WANCKET; Fiscal Year: 2013
    ..negatively regulates the innate immune response and limits clinical disease during primary and secondary bacterial pneumonia. In this mentored research award, this hypothesis will be tested using mouse models of Streptococcus ..
  25. 2012 Biology of Acute Respiratory Infection Gordon Research Conference
    Alice S Prince; Fiscal Year: 2012
    ..Topics will include major causes of bacterial pneumonia, Streptococcus pneumoniae, Staphylococcus aureus (especially MRSA) Mycoplasma pneumoniae and pertussis...
  26. Immune response to pneumococcal vaccination in aging HIV positive adults.
    M A JULIA WESTERINK; Fiscal Year: 2013
    DESCRIPTION: Streptococcus pneumonia is the most common cause of bacterial pneumonia in HIV+ individuals...
  27. Interferon-mediated reprogramming of Toll-like receptor signaling
    Lesley A Doughty; Fiscal Year: 2012
    ..A good example of which is bacterial pneumonia following influenza which was first noted to contribute to death from influenza as far back as the ..
  28. Sinusitis in Children and the Nasopharyngeal Microbiome
    Ellen Wald; Fiscal Year: 2013
    ..of the respiratory tract in which there is an antecedent viral infection (acute otitis media, acute bacterial pneumonia and acute bacterial sinusitis)...
  29. Mechanism and pathophysiological significance of mast cell regulated exocytosis
    Roberto Adachi; Fiscal Year: 2013
    ..mast cell degranulation- deficient mice in models of chronic allergic asthma, inflammatory arthritis, and bacterial pneumonia. Our genetically modified mice may reveal if mast cell degranulation is an attractive and safe therapeutic ..
  30. Epidemiology and Etiology of Hospitalized Pneumonia in Children
    Krow Ampofo; Fiscal Year: 2013
    ..Salt Lake County, including primary viral pneumonia, viral and bacterial co-infection, and post-influenza bacterial pneumonia. Specific Aim 3: Document the bacterial and viral etiology of pediatric pneumonia due to established and ..
  31. IL-23 / Il-17 and Lung Host Defense
    Jay Kolls; Fiscal Year: 2009
    b>Bacterial pneumonia is an important clinical problem and host defense mechanisms against pneumonia are not fully understood...
  32. Proteoglycans in Lung Innate Immunity and Host Defense
    Pyong Woo Park; Fiscal Year: 2012
    ..Streptococcus pneumoniae, the pneumococcus, is the most common causative agent of community-acquired bacterial pneumonia. It is estimated that this Gram-positive bacterium causes 500,000 cases of pneumonia and 40,000 deaths ..
  33. Regulation of alveolar barrier function by claudins
    James A Frank; Fiscal Year: 2013
    ..We will investigate the mechanism for the regulation of claudin-18 and claudin-4 using a bacterial pneumonia model in the ex vivo system...
  34. Epithelial Cell Bactercidal/Permeability Increasing Protein in Lung Injury
    Joan G Clark; Fiscal Year: 2010
    ..this basic information about the mechanisms by which BPI modulated LPS signaling to a murine model of bacterial pneumonia and LPS-induced lung inflammation...
  35. Multiscale Modeling of Pilin Subunit Recognition by Pneumoccus Sortase C enzymes
    JEFFERY WERESZCZYNSKI; Fiscal Year: 2013
    ..particularly among the young and the elderly, and is the leading cause of multiple diseases, including bacterial pneumonia, sepsis, and meningitis...
  36. The Biology of LIF During Pneumonia
    Lee Quinton; Fiscal Year: 2013
    ..We have recently shown that during bacterial pneumonia, the cytokine leukemia inhibitory factor (LIF) is critical for activation of the transcription factor STAT3,..
  37. Flagellin Stimulates Lung Innate Mucosal Immunity
    Theodore J Standiford; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Bacterial pneumonia is a frequent and deadly complication in hospitalized patients...
  38. Mechanisms of impaired neutrophil responses in postinfluenza bacterial pneumonia
    Jane C Deng; Fiscal Year: 2013
    ..post-influenza pulmonary infections by Streptococcal pneumoniae, which is the most significant cause of bacterial pneumonia worldwide...
  39. Alcohol intoxication &Shock;specific needs &targeted resuscitation strategies
    Jesse Sulzer; Fiscal Year: 2012
    ..during the early recovery as well as increased mortality in AAI-intoxicated animals in response to bacterial pneumonia during the recovery period Investigations into the mechanism of the AAI- induced impairment of hemodynamic ..
  40. Role of IRAK-M in sepsis-induced immunosuppression
    Jane C Deng; Fiscal Year: 2010
    ..Patients who survive sepsis remain highly susceptible to subsequent nosocomial infections, particularly bacterial pneumonia. Alveolar macrophages are functionally impaired following sepsis, characterized by diminished inflammatory ..
  41. The Promotion of Inflammation by Bacterial Sialidases After Influenza Infection
    NICHOLAS KORTEN BROWN; Fiscal Year: 2013
    ..in some of the most challenging infectious diseases, including AIDS, Ebola hemorrhagic fever, sepsis, and bacterial pneumonia secondary to influenza infection...
  42. Cross-serotype protection against Streptococcus pneumoniae by induction of neutra
    Edward N Janoff; Fiscal Year: 2012
    ..by applicant): Effective vaccination against Streptococcus pneumoniae, the most common and serious cause of bacterial pneumonia in children and adults, is complicated by the high number of antigenically-distinct capsular serotypes that ..
  43. Risk, Severity and Outcome of Bacterial Pneumonia in an HIV +/- Veteran Cohort
    KRISTINA ANNE CROTHERS; Fiscal Year: 2010
    ..data from the Veterans Aging Cohort Study (VACS) to examine risk factors for incidence and severity of bacterial pneumonia in HIV infected (HIV+) compared to HIV uninfected (HIV-) patients...
  44. Participation of Mucosal Type I Interferon Signaling in Pulmonary Disease
    Alice S Prince; Fiscal Year: 2010
    ..Activation of this cascade may be an important factor contributing to post-influenza bacterial pneumonia, the major cause of mortality associated with influenza infection.
  45. HIV activation in secondary pulmonary infection
    Michael D Weiden; Fiscal Year: 2013
    ..funded R01-supported study, for which I am a co-PI, is titled "Longitudinal Studies of HIV-Associated Bacterial Pneumonia." This study extends the work of the laboratory to investigate bacterial pneumonia...
  46. HIV Compromises Lung Macrophage TLR Host Defense Function
    Souvenir D Tachado; Fiscal Year: 2013
    ..The fact that HIV+ persons with relatively preserved CD4-T-cell counts remain at high risk for bacterial pneumonia suggest the possibility that impaired function of other lung immune cells such as alveolar macrophages (AM) ..
  47. MicroRNA uridylation by Zcchc11 regulates pulmonary inflammation
    MATTHEW ROBERT JONES; Fiscal Year: 2013
    ..The pulmonary immune response during bacterial pneumonia is a tightly regulated process that eliminates bacteria while preventing host tissue damage due to ..
  48. IDENTIFY ANTIGENIC DETERMINANTS OF HUMAN PERIODONTITIS
    YEN TUNG TENG; Fiscal Year: 2001
    ..and has been recognised as a significant risk factor associated with coronary heart disease, stroke and bacterial pneumonia. The long-term objective of this research program is to identify bacterial antigens important for immune ..
  49. Mulago Inpatient Noninvasive Diagnosis of Pneumocystis Pneumonia (MIND PCP) Study
    John Davis; Fiscal Year: 2007
    ..While tuberculosis (TB) and bacterial pneumonia are common, other processes may cause pneumonia in these patients, so bronchoscopy with bronchoalveolar ..
  50. Novel anti-bacterial therapy for gram negative pneumonia
    Kanneganti Murthy; Fiscal Year: 2001
    ..test the in vivo protective action of 14 proprietary murine mAb's in a murine model of acute gram negative bacterial pneumonia produced by intratracheal bacterial inoculation of E. coil...
  51. IMMUNOLOGY OF BACTERIAL PNEUMONIA IN HTLV-II INFECTION
    GARY JARVIS; Fiscal Year: 2002
    ..understand the immunologic basis for the epidemiological outcome observation of an increased incidence of bacterial pneumonia in HTLV-II-infected blood donors...
  52. IL-17 and Klebsiella Pneumonia
    JUDD SHELLITO; Fiscal Year: 2007
    ..of this project is to understand interactions between cellular and soluble factors in host defense against bacterial pneumonia. Preliminary data from our laboratory indicate that deposition of bacteria (Klebsiella pneumoniae) into the ..
  53. Mast Cells and the Host Response in the Lung
    Paul Wolters; Fiscal Year: 2007
    ..This knowledge can then be applied to the development of new treatments for bacterial pneumonia that modulate the activity of specific mast cells proteins in ways that improve survival.
  54. Therapeutic scFv antibody for human periodontitis
    YEN TUNG TENG; Fiscal Year: 2005
    ..disease has been shown to be associated with an increased risk for coronary heart disease, stroke, bacterial pneumonia, diabetes and undesired pregnant outcomes...
  55. NEW SYNTHETIC APPLICATION OF BENZENE PHOTOCHEMISTRY
    Richard Johnson; Fiscal Year: 1990
    ..Although bacterial pneumonia is one of the leading causes of death amongst alcoholics, little knowledge exists concerning alcohol-..
  56. Alcohol and Impairment of the Granulopoietic Response to Pneumonia
    Ping Zhang; Fiscal Year: 2010
    ..we will investigate the cell signaling mechanisms by which alcohol impairs the granulopoietic response to bacterial pneumonia. Our hypothesis is that alcohol suppresses the granulopoietic response to pneumococcal pneumonia by ..
  57. Host response to post-operative pneumonia
    Paul Knight; Fiscal Year: 2005
    ..Our focus is to examine cellular mechanisms during a viral RTI that predispose the host to a post-surgical bacterial pneumonia. We hypothesize that anesthesia/surgery will change host responses differently during distinct periods in ..
  58. MEDICAL CONSEQUENSES OF HTLV II IN DRUG ABUSERS
    Edward Murphy; Fiscal Year: 1999
    ..It is well recognized that IDU have a high incidence of infectious diseases, including bacterial pneumonia and skin and soft tissue abscess...
  59. Community correlates of pneumonia hospitalization and mortality
    FRANK LEMUS; Fiscal Year: 2006
    ..examine the effect of contextual factors on health care quality using two AHRQ quality of care indicators: bacterial pneumonia hospitalization rates and pneumonia in patient mortality rates...
  60. Alcohol, Pulmonary Cytokines, and Host Defense
    Kyle Happel; Fiscal Year: 2009
    ..current focus involves alcohol's effect on the development of a coordinated host defense response to bacterial pneumonia. Through inhibition of cytokines such as IL-12 which functionally link innate and adaptive immunity, ..
  61. Munc18 Proteins in Airway Mucus Hypersecretion
    Burton Dickey; Fiscal Year: 2006
    ..the protective and pathophysiologic roles of mucus hypersecretion in murine models of allergic asthma and bacterial pneumonia by reducing the capability of airway goblet cells to secrete mucus through reduction of Munc18B expression...
  62. The contribution of heat shock/stress pathways to acute lung injury
    Jeffrey D Hasday; Fiscal Year: 2010
    ..regulating CXC chemokines and GM-CSF in vitro and in the mouse intratracheal LPS challenge model of diffuse bacterial pneumonia and analyze how FRH increases neutrophil responsiveness to FRH...
  63. Analysis of F-box domain containing effector proteins from Legionella pneumophila
    Stanimir Ivanov; Fiscal Year: 2009
    ..The intracellular human pathogen Legionella pneumophila is the causative agent of the severe bacterial pneumonia known as Legionnaire's disease...
  64. SURFACTANT PROTEIN A IN PULMONARY HOST DEFENSE
    Francis McCormack; Fiscal Year: 2002
    b>Bacterial pneumonia is a leading cause of morbidity and mortality in the United States. Infection is initiated by inhaled microorganisms that are deposited in the aqueous lining film which coats the alveolar epithelium...