bacterial infections

Summary

Summary: Infections by bacteria, general or unspecified.

Top Publications

  1. ncbi Biofilms in chronic infections - a matter of opportunity - monospecies biofilms in multispecies infections
    Mette Burmølle
    Department of Biology, University of Copenhagen, Denmark
    FEMS Immunol Med Microbiol 59:324-36. 2010
  2. pmc Pyogenic bacterial infections in humans with MyD88 deficiency
    Horst von Bernuth
    Human Genetics of Infectious Diseases, INSERM U550, Paris, France
    Science 321:691-6. 2008
  3. ncbi Modulating immunity as a therapy for bacterial infections
    Robert E W Hancock
    Department of Microbiology and Immunology, Centre for Microbial Diseases and Immunity Research, Room 232, 2259 Lower Mall Research Station, University of British Columbia, Vancouver, V6T 1Z4 British Columbia, Canada
    Nat Rev Microbiol 10:243-54. 2012
  4. ncbi The mammalian microRNA response to bacterial infections
    Ana Eulalio
    Institute for Molecular Infection Biology IMIB and Research Centre for Infection Diseases ZINF, University of Wurzburg, Wurzburg, Germany
    RNA Biol 9:742-50. 2012
  5. ncbi Community-based treatment of serious bacterial infections in newborns and young infants: a randomized controlled trial assessing three antibiotic regimens
    Anita K M Zaidi
    Department of Pediatrics and Child Health, Aga Khan University, Karachi, Pakistan
    Pediatr Infect Dis J 31:667-72. 2012
  6. ncbi Detection of anaerobic bacteria in high numbers in sputum from patients with cystic fibrosis
    Michael M Tunney
    School of Pharmacy, Medical Biology Centre, Queen s University Belfast, Belfast, United Kingdom
    Am J Respir Crit Care Med 177:995-1001. 2008
  7. pmc The accuracy of clinical symptoms and signs for the diagnosis of serious bacterial infection in young febrile children: prospective cohort study of 15 781 febrile illnesses
    Jonathan C Craig
    Screening and Test Evaluation Program, School of Public Health, University of Sydney, Sydney, Australia
    BMJ 340:c1594. 2010
  8. pmc Survey of bacterial diversity in chronic wounds using pyrosequencing, DGGE, and full ribosome shotgun sequencing
    Scot E Dowd
    United States Department of Agriculture ARS Livestock Issues Research Unit, Lubbock, TX, USA
    BMC Microbiol 8:43. 2008
  9. ncbi Childhood asthma after bacterial colonization of the airway in neonates
    Hans Bisgaard
    Danish Pediatric Asthma Center, Copenhagen University Hospital, Gentofte, Copenhagen
    N Engl J Med 357:1487-95. 2007
  10. doi Federal funding for the study of antimicrobial resistance in nosocomial pathogens: no ESKAPE
    Louis B Rice
    J Infect Dis 197:1079-81. 2008

Detail Information

Publications303 found, 100 shown here

  1. ncbi Biofilms in chronic infections - a matter of opportunity - monospecies biofilms in multispecies infections
    Mette Burmølle
    Department of Biology, University of Copenhagen, Denmark
    FEMS Immunol Med Microbiol 59:324-36. 2010
    ..We discuss these differences from both the diagnostic and the scientific point of view...
  2. pmc Pyogenic bacterial infections in humans with MyD88 deficiency
    Horst von Bernuth
    Human Genetics of Infectious Diseases, INSERM U550, Paris, France
    Science 321:691-6. 2008
    ..children with autosomal recessive MyD88 deficiency suffered from life-threatening, often recurrent pyogenic bacterial infections, including invasive pneumococcal disease...
  3. ncbi Modulating immunity as a therapy for bacterial infections
    Robert E W Hancock
    Department of Microbiology and Immunology, Centre for Microbial Diseases and Immunity Research, Room 232, 2259 Lower Mall Research Station, University of British Columbia, Vancouver, V6T 1Z4 British Columbia, Canada
    Nat Rev Microbiol 10:243-54. 2012
    ..A range of potential immune modulators have been proposed, including innate defence regulator peptides and agonists of innate immune components such as Toll-like receptors and NOD-like receptors...
  4. ncbi The mammalian microRNA response to bacterial infections
    Ana Eulalio
    Institute for Molecular Infection Biology IMIB and Research Centre for Infection Diseases ZINF, University of Wurzburg, Wurzburg, Germany
    RNA Biol 9:742-50. 2012
    ..In this review, we discuss the emerging roles of microRNAs in mammalian host signaling and defense against bacterial pathogens...
  5. ncbi Community-based treatment of serious bacterial infections in newborns and young infants: a randomized controlled trial assessing three antibiotic regimens
    Anita K M Zaidi
    Department of Pediatrics and Child Health, Aga Khan University, Karachi, Pakistan
    Pediatr Infect Dis J 31:667-72. 2012
    ....
  6. ncbi Detection of anaerobic bacteria in high numbers in sputum from patients with cystic fibrosis
    Michael M Tunney
    School of Pharmacy, Medical Biology Centre, Queen s University Belfast, Belfast, United Kingdom
    Am J Respir Crit Care Med 177:995-1001. 2008
    ..Pulmonary infection in cystic fibrosis (CF) is polymicrobial and it is possible that anaerobic bacteria, not detected by routine aerobic culture methods, reside within infected anaerobic airway mucus...
  7. pmc The accuracy of clinical symptoms and signs for the diagnosis of serious bacterial infection in young febrile children: prospective cohort study of 15 781 febrile illnesses
    Jonathan C Craig
    Screening and Test Evaluation Program, School of Public Health, University of Sydney, Sydney, Australia
    BMJ 340:c1594. 2010
    ..infection are diagnosed and treated, and to develop and test a multivariable model to distinguish serious bacterial infections from self limiting non-bacterial illnesses. Design Two year prospective cohort study...
  8. pmc Survey of bacterial diversity in chronic wounds using pyrosequencing, DGGE, and full ribosome shotgun sequencing
    Scot E Dowd
    United States Department of Agriculture ARS Livestock Issues Research Unit, Lubbock, TX, USA
    BMC Microbiol 8:43. 2008
    ....
  9. ncbi Childhood asthma after bacterial colonization of the airway in neonates
    Hans Bisgaard
    Danish Pediatric Asthma Center, Copenhagen University Hospital, Gentofte, Copenhagen
    N Engl J Med 357:1487-95. 2007
    ..We conducted a study to investigate a possible association between bacterial colonization of the hypopharynx in asymptomatic neonates and later development of recurrent wheeze, asthma, and allergy during the first 5 years of life...
  10. doi Federal funding for the study of antimicrobial resistance in nosocomial pathogens: no ESKAPE
    Louis B Rice
    J Infect Dis 197:1079-81. 2008
  11. ncbi Characteristics and outcomes of public campaigns aimed at improving the use of antibiotics in outpatients in high-income countries
    Benedikt Huttner
    Infection Control Programme, Geneva University Hospitals and Medical School, Geneva, Switzerland
    Lancet Infect Dis 10:17-31. 2010
    ..Although the most effective interventions and potential adverse outcomes remain unclear, public campaigns can probably contribute to more careful use of antibiotics in outpatients, at least in high-prescribing countries...
  12. ncbi Manipulation of host cell death pathways during microbial infections
    Mohamed Lamkanfi
    Department of Biochemistry, Ghent University, B 9000 Ghent, Belgium
    Cell Host Microbe 8:44-54. 2010
    ..Herein, we discuss the signaling pathways underlying the principal host cell death mechanisms and provide an overview of the strategies employed by viral and microbial pathogens to manipulate these cell death processes...
  13. ncbi Metagenomic analysis of bacterial infections by means of high-throughput DNA sequencing
    Shota Nakamura
    Department of Infection Metagenomics, Genome Information Research Center, Osaka University, 3 1 Yamadaoka, Suita, Osaka 565 0871, Japan
    Exp Biol Med (Maywood) 236:968-71. 2011
    ..We have been applying these new sequencers to the analysis of infectious diseases, especially bacterial infections. We review the efficacy of these sequencers, mainly based on our own experiences...
  14. pmc The epidemiology of antibiotic resistance in hospitals: paradoxes and prescriptions
    M Lipsitch
    Department of Biology, Emory University, 1510 Clifton Road, Atlanta, GA 30322, USA
    Proc Natl Acad Sci U S A 97:1938-43. 2000
    ..The predictions of the model are compared with those of other models and published data. The implications for resistance control and study design are discussed, along with the limitations and assumptions of the model...
  15. pmc Vector-borne diseases--constant challenge for practicing veterinarians: recommendations from the CVBD World Forum
    Gad Baneth
    Koret School of Veterinary Medicine, The Robert H Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem Rehovot, Israel
    Parasit Vectors 5:55. 2012
    ..As a result of these discussions, we, the members of the CVBD Forum have developed the following recommendations to veterinarians for the management of CVBDs...
  16. ncbi The damage-response framework of microbial pathogenesis
    Arturo Casadevall
    Departments of Medicine Division of Infectious Diseases and Microbiology and Immunology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
    Nat Rev Microbiol 1:17-24. 2003
    ..To address this impediment to studies of host-microorganism interactions, we propose a new theoretical approach to understanding microbial pathogenesis, known as the 'damage-response' framework...
  17. pmc Metagenomic diagnosis of bacterial infections
    Shota Nakamura
    International Research Center for Infectious Diseases, Research Institute for Microbial Diseases, Osaka University, Suita, Japan
    Emerg Infect Dis 14:1784-6. 2008
    ..Sequences showing best matches for Campylobacter jejuni were detected only in the illness sample. Various bacteria may be detectable with this metagenomic approach...
  18. ncbi Eater, a transmembrane protein mediating phagocytosis of bacterial pathogens in Drosophila
    Christine Kocks
    Laboratory of Developmental Immunology, Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Cell 123:335-46. 2005
    ..Our results suggest that Eater is a major phagocytic receptor for a broad range of bacterial pathogens in Drosophila and provide a powerful model to address the role of phagocytosis in vivo...
  19. pmc Stroke-induced immunodeficiency promotes spontaneous bacterial infections and is mediated by sympathetic activation reversal by poststroke T helper cell type 1-like immunostimulation
    Konstantin Prass
    Department of Experimental Neurology, Charite Hospital, Humboldt University, Schumannstrasse 20 21, D 10098 Berlin, Germany
    J Exp Med 198:725-36. 2003
    ..ischemia, we tested the hypothesis that a stroke-induced immunodeficiency increases the susceptibility to bacterial infections. 3 d after ischemia, all animals developed spontaneous septicemia and pneumonia...
  20. ncbi Meta-analysis: antibiotic prophylaxis reduces mortality in neutropenic patients
    Anat Gafter-Gvili
    Rabin Medical Center, Petah Tiqva, Israel
    Ann Intern Med 142:979-95. 2005
    b>Bacterial infections are a major cause of illness and death in patients who are neutropenic after chemotherapy treatment for cancer...
  21. pmc p38 MAPK regulates expression of immune response genes and contributes to longevity in C. elegans
    Emily R Troemel
    Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Genet 2:e183. 2006
    ..The contribution of the PMK-1 pathway to the enhanced lifespan of daf-2 mutants suggests that innate immunity is an important determinant of longevity...
  22. ncbi Population and evolutionary dynamics of phage therapy
    Bruce R Levin
    Department of Biology, Emory University, Atlanta, Georgia 30307, USA
    Nat Rev Microbiol 2:166-73. 2004
    ..hiatus in western medicine, bacteriophages (phages) are again being advocated for treating and preventing bacterial infections. Are attempts to use phages for clinical and environmental applications more likely to succeed now than in ..
  23. ncbi Antimicrobial peptides: new candidates in the fight against bacterial infections
    Orsolya Toke
    Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St Louis, MO 63110, USA
    Biopolymers 80:717-35. 2005
    ..The emphasis will be on linear AMPs but representatives of cysteine-bridged AMPs will also be discussed...
  24. pmc WHO guidelines for antimicrobial treatment in children admitted to hospital in an area of intense Plasmodium falciparum transmission: prospective study
    Behzad Nadjm
    London School of Hygiene and Tropical Medicine, London WCIE 7HT
    BMJ 340:c1350. 2010
    To assess the performance of WHO's "Guidelines for care at the first-referral level in developing countries" in an area of intense malaria transmission and identify bacterial infections in children with and without malaria.
  25. pmc Etiology of acute, non-malaria, febrile illnesses in Jayapura, northeastern Papua, Indonesia
    Narain H Punjabi
    U S Naval Medical Research Unit No 2, Jakarta, Indonesia
    Am J Trop Med Hyg 86:46-51. 2012
    ..There were 17 deaths, 7 (46.7%) were caused by meningitis/encephalitis. Multiple positive serologic results and few confirmed diagnoses indicate the need for improved diagnostics...
  26. pmc The application of biofilm science to the study and control of chronic bacterial infections
    William Costerton
    Center for Biofilm Engineering, Montana State University, Bozeman, Montana 59717 3980, USA
    J Clin Invest 112:1466-77. 2003
    ..We discuss the potential benefits of the application of the new methods and concepts developed by biofilm science and engineering to the clinical management of infectious diseases...
  27. ncbi Antibiotic heterogeneity: from concept to practice
    A M Bal
    Departments of Medical Microbiology, Crosshouse Hospital, Kilmarnock, Scotland, United Kingdom
    Ann N Y Acad Sci 1213:81-91. 2010
    ..This review summarizes the available information on antibiotic heterogeneity (antibiotic cycling, antibiotic mixing, and other types of antibiotic protocols) with a critical analysis of the published studies...
  28. ncbi Is procalcitonin useful in early diagnosis of serious bacterial infections in children?
    Sudhin Thayyil
    Department of Paediatrics and Chemical Pathology, University Hospital of North Tees and Hartlepool, UK
    Acta Paediatr 94:155-8. 2005
    ..To compare diagnostic accuracy of procalcitonin for early diagnosis of serious bacterial infection (SBI) in children presenting with fever and no focus of infection...
  29. ncbi Induction of the human cathelicidin LL-37 as a novel treatment against bacterial infections
    Anne M van der Does
    Departments of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
    J Leukoc Biol 92:735-42. 2012
    ..Here, we summarize current data on the effects that LL-37 and its inducers display on the innate immune response and discuss the feasibility for development of these inducers as possible drugs to prevent or treat infections...
  30. pmc The burden of invasive bacterial infections in Pemba, Zanzibar
    Kamala Thriemer
    International Vaccine Institute, Seoul, Republic of Korea
    PLoS ONE 7:e30350. 2012
    ..We conducted a surveillance study to determine the leading causes of bloodstream infection in febrile patients seeking treatment at three district hospitals in Pemba Island, Zanzibar, Tanzania, an area with low malaria transmission...
  31. ncbi Management of bacterial infections in cirrhosis
    Javier Fernandez
    Liver Unit, IMDiM, Hospital Clinic, Universidad de Barcelona, IDIBAPS and Ciberehd, Barcelona, Spain
    J Hepatol 56:S1-12. 2012
    b>Bacterial infections are very frequent in advanced cirrhosis and become the first cause of death of these patients...
  32. ncbi Lectin complement pathway gene profile of donor and recipient determine the risk of bacterial infections after orthotopic liver transplantation
    Bert Jan F de Rooij
    Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, The Netherlands
    Hepatology 52:1100-10. 2010
    ..We assessed the relationship between these polymorphic genes and clinically significant bacterial infections, i.e...
  33. ncbi An in vitro model of bacterial infections in wounds and other soft tissues
    Maria Werthén
    Molnlycke Health Care, Goteborg, Sweden
    APMIS 118:156-64. 2010
    ..This model may be used to study biofilm development in chronic wounds and to develop novel diagnostic tools as well as treatment strategies...
  34. pmc Prevalence of Dirofilaria immitis, Ehrlichia canis, Borrelia burgdorferi sensu lato, Anaplasma spp. and Leishmania infantum in apparently healthy and CVBD-suspect dogs in Portugal--a national serological study
    Luis Cardoso
    Department of Veterinary Sciences, School of Agrarian and Veterinary Sciences, University of Tras os Montes e Alto Douro, Vila Real, Portugal
    Parasit Vectors 5:62. 2012
    ..The present study aimed at assessing the seroprevalence of infection with or exposure to Dirofilaria immitis, Ehrlichia canis, Borrelia burgdorferi sensu lato, Anaplasma spp. and Leishmania infantum in dogs in Portugal...
  35. ncbi Respiratory viruses predisposing to bacterial infections: role of neuraminidase
    Ville T Peltola
    Department of Infectious Diseases, St Judes Children s Research Hospital, Memphis, TN, USA
    Pediatr Infect Dis J 23:S87-97. 2004
    ..This article focuses on viral and bacterial combinations, particularly synergism between influenza and Streptococcus pneumoniae...
  36. ncbi Targeting of immune signalling networks by bacterial pathogens
    Igor E Brodsky
    Section of Immunobiology, Yale University School of Medicine New Haven, CT 06520, USA
    Nat Cell Biol 11:521-6. 2009
    ..By contrast, pathogens that cause chronic or persistent infections tend to target more peripheral signalling network components (nodes) to promote pathogen persistence...
  37. pmc Innate immune detection of the type III secretion apparatus through the NLRC4 inflammasome
    Edward A Miao
    Institute for Systems Biology, Seattle, WA 98103, USA
    Proc Natl Acad Sci U S A 107:3076-80. 2010
    ..Furthermore, the specific detection of the virulence machinery permits the discrimination between pathogenic and nonpathogenic bacteria...
  38. pmc Pharmacological inhibition of quorum sensing for the treatment of chronic bacterial infections
    Morten Hentzer
    Center for Biomedical Microbiology, BioCentrum, Building 301, Technical University of Denmark, DK 2800 Lyngby, Denmark
    J Clin Invest 112:1300-7. 2003
    ..Herein we discuss the known signaling mechanisms and potential antipathogenic drugs that specifically target quorum-sensing systems in a manner unlikely to pose a selective pressure for the development of resistant mutants...
  39. ncbi Levofloxacin to prevent bacterial infection in patients with cancer and neutropenia
    Giampaolo Bucaneve
    Policlinico Monteluce, Perugia, Italy
    N Engl J Med 353:977-87. 2005
    ..The prophylactic use of fluoroquinolones in patients with cancer and neutropenia is controversial and is not a recommended intervention...
  40. pmc Clinical features and outcome of patients with IRAK-4 and MyD88 deficiency
    Capucine Picard
    Study Center of Primary Immunodeficiencies, Assistance Publique Hopitaux de Paris, Paris, France
    Medicine (Baltimore) 89:403-25. 2010
    ..There were no severe viral, parasitic, and fungal diseases, and the range of bacterial infections was narrow...
  41. ncbi Bacterial infections in cirrhosis: epidemiological changes with invasive procedures and norfloxacin prophylaxis
    Javier Fernandez
    Liver Unit, IMD, and Department of Microbiology and IDIBAPS, Hospital Clinic, University of Barcelona, Barcelona, Spain
    Hepatology 35:140-8. 2002
    ..norfloxacin prophylaxis in the management of cirrhotic patients may have influenced the epidemiology of bacterial infections in cirrhosis...
  42. ncbi Optimizing drug exposure to minimize selection of antibiotic resistance
    Sara K Olofsson
    Antibiotic Research Unit, Department of Medical Sciences, Clinical Bacteriology and Infectious Diseases, Uppsala University, Uppsala, Sweden
    Clin Infect Dis 45:S129-36. 2007
    ....
  43. ncbi The melanization reaction is not required for survival of Anopheles gambiae mosquitoes after bacterial infections
    Anna K D Schnitger
    Imperial College London, Division of Cell and Molecular Biology, Exhibition Road, London, UK
    J Biol Chem 282:21884-8. 2007
    ..bacteria are efficiently melanized in the hemocoel, but the contribution of melanization to survival after bacterial infections has not been established...
  44. ncbi Procalcitonin for guidance of antibiotic therapy
    Philipp Schuetz
    Harvard School of Public Health, MA, USA
    Expert Rev Anti Infect Ther 8:575-87. 2010
    ..This review aims to provide physicians with an overview of the strengths and limitations of procalcitonin guidance for antibiotic therapy when used in different clinical settings and in patients with different underlying infections...
  45. pmc Quorum sensing and the population-dependent control of virulence
    P Williams
    Institute of Infections and Immunity, Queen s Medical Centre, University of Nottingham, UK
    Philos Trans R Soc Lond B Biol Sci 355:667-80. 2000
    One crucial feature of almost all bacterial infections is the need for the invading pathogen to reach a critical cell population density sufficient to overcome host defences and establish the infection...
  46. ncbi Diversity of endodontic microbiota revisited
    J F Siqueira
    Department of Endodontics and Molecular Microbiology, Faculty of Dentistry, Estacio de Sa University, Av Alfredo Baltazar da Silveira, 580 Cobertura, Recreio, Rio de Janeiro, RJ, Brazil
    J Dent Res 88:969-81. 2009
    ....
  47. pmc The p47phox mouse knock-out model of chronic granulomatous disease
    S H Jackson
    Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 1886, USA
    J Exp Med 182:751-8. 1995
    ..This model mirrors human CGD and confirms a critical role for the phagocyte NADPH oxidase in mammalian host defense...
  48. ncbi Rotating antibiotics selects optimally against antibiotic resistance, in theory
    Robert E Beardmore
    Department of Mathematics, Imperial College London, SW7 2AZ, London, United Kingdom
    Math Biosci Eng 7:527-52. 2010
    ....
  49. ncbi Bacterial infections, sepsis, and multiorgan failure in cirrhosis
    Puneeta Tandon
    Division of Gastroenterology, University of Alberta, Edmonton, Alberta, Canada
    Semin Liver Dis 28:26-42. 2008
    b>Bacterial infections are an important complication of cirrhosis, particularly in hospitalized patients...
  50. pmc Sustained desensitization to bacterial Toll-like receptor ligands after resolution of respiratory influenza infection
    Arnaud Didierlaurent
    Kennedy Institute of Rheumatology, Imperial College London, London W6 8LH, England, UK
    J Exp Med 205:323-9. 2008
    ..Our data therefore suggests that post-viral desensitization to TLR signals may be one possible contributor to the common secondary bacterial pneumonia associated with pandemic and seasonal influenza infection...
  51. ncbi Critical shortage of new antibiotics in development against multidrug-resistant bacteria-Time to react is now
    Laura Freire-Moran
    European Medicines Agency EMA, London, United Kingdom
    Drug Resist Updat 14:118-24. 2011
    ..There is an urgent need to address the lack of effective treatments to meet the increasing public health burden caused by multidrug-resistant bacteria, in particular against Gram-negative bacteria...
  52. ncbi Procalcitonin algorithms for antibiotic therapy decisions: a systematic review of randomized controlled trials and recommendations for clinical algorithms
    Philipp Schuetz
    Department of Emergency Medicine, Harvard School of Public Health, Boston, MA 02115, USA
    Arch Intern Med 171:1322-31. 2011
    ..controlled trials suggest that using clinical algorithms based on procalcitonin levels, a marker of bacterial infections, results in reduced antibiotic use without a deleterious effect on clinical outcomes...
  53. ncbi The challenge of treating biofilm-associated bacterial infections
    J L del Pozo
    Division of Infectious Diseases, Mayo Clinic, Rochester, Minnesota, USA
    Clin Pharmacol Ther 82:204-9. 2007
    Biofilm formation is a crucial step in the pathogenesis of many subacute and chronic bacterial infections, including foreign body-related infections. Biofilms are difficult to eradicate with conventional antimicrobial agents...
  54. ncbi Antibiotic prophylaxis for the prevention of bacterial infections in cirrhotic patients with gastrointestinal bleeding: a meta-analysis
    B Bernard
    Service d Hepato Gastroenterologie, Hopital Pitie Salpetriere, Paris, France
    Hepatology 29:1655-61. 1999
    ..In cirrhotic patients with gastrointestinal bleeding, short-term antibiotic prophylaxis significantly increases the mean percentage of patients free of infection and significantly increases short-term survival rate...
  55. ncbi Transgenic zebrafish reporter lines reveal conserved Toll-like receptor signaling potential in embryonic myeloid leukocytes and adult immune cell lineages
    Chris Hall
    Department of Molecular Medicine and Pathology, School of Medical Sciences, The University of Auckland, Auckland, New Zealand
    J Leukoc Biol 85:751-65. 2009
    ..These lines will provide a valuable resource for further resolving the contribution of MyD88 to early vertebrate immunity...
  56. ncbi Cigarette smoking and infection
    Lidia Arcavi
    Clinical Pharmacology Unit, Kaplan Medical Center, Rehovot, Israel
    Arch Intern Med 164:2206-16. 2004
    ..We reviewed mechanisms by which smoking increases the risk of infection and the epidemiology of smoking-related infection, and delineated implications of this increased risk of infection among cigarette smokers...
  57. ncbi The relationship between antimicrobial resistance and patient outcomes: mortality, length of hospital stay, and health care costs
    Sara E Cosgrove
    Division of Infectious Diseases, The Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    Clin Infect Dis 42:S82-9. 2006
    ..Strategies to prevent nosocomial emergence and spread of antimicrobial-resistant organisms are essential...
  58. ncbi Diagnosis and treatment of diabetic foot infections
    Benjamin A Lipsky
    Medical Service, Veterans Affairs Puget Sound Health Care System, and Division of General Internal Medicine, Department of Medicine, University of Washington School of Medicine, Seattle, Washington 98108 9804, USA
    Clin Infect Dis 39:885-910. 2004
  59. pmc Epigenetics and bacterial infections
    Helene Bierne
    Institut Pasteur, Unité des Interactions Bactéries Cellules, Paris F 75015, France
    Cold Spring Harb Perspect Med 2:a010272. 2012
    ..Their effects might generate specific, long-lasting imprints on host cells, leading to a memory of infection that influences immunity and might be at the origin of unexplained diseases...
  60. ncbi Procalcitonin, IL-6, IL-8, IL-1 receptor antagonist and C-reactive protein as identificators of serious bacterial infections in children with fever without localising signs
    A G Lacour
    Département de Pédiatrie HUG, H pital des Enfants, Geneve, Switzerland
    Eur J Pediatr 160:95-100. 2001
    ..PCT showed a sensitivity of 93% and a specificity of 78% for detection of SBI and CRP had a sensitivity of 89% and a specificity of 75%...
  61. ncbi The critical influence of the intermediate category on interpretation errors in revised EUCAST and CLSI antimicrobial susceptibility testing guidelines
    M Hombach
    Institute of Medical Microbiology, University of Zurich, Zurich, Switzerland
    Clin Microbiol Infect 19:E59-71. 2013
    ..Laboratories should know their epidemiology settings to be able to detect problems of individual species/drug/clinical breakpoint combinations and take measures to improve precision of diameter measurements...
  62. ncbi Clinical significance of serum procalcitonin levels in patients with acute or chronic liver disease
    Ioannis S Elefsiniotis
    Department of Internal Medicine, Hippokration Hospital of Athens, Carchidonos 9, A Glyfada, GR 16562 Greece
    Eur J Gastroenterol Hepatol 18:525-30. 2006
    ..diagnostic value of serum procalcitonin levels in patients with acute or chronic liver disease, with or without bacterial infections and to correlate the results with the clinical outcome and the laboratory findings for these patients.
  63. ncbi Practice guidelines for the diagnosis and management of skin and soft-tissue infections
    Dennis L Stevens
    Infectious Diseases Section, Veterans Affairs Medical Center, Boise, Idaho 83702, USA
    Clin Infect Dis 41:1373-406. 2005
  64. ncbi Multiplex PCR and emerging technologies for the detection of respiratory pathogens
    Angela M Caliendo
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Emory Center for AIDS Research, Emory University, Atlanta, Georgia 30322, USA
    Clin Infect Dis 52:S326-30. 2011
    ..This review will focus on emerging multiplex molecular technologies and their clinical utility for the detection of respiratory pathogens...
  65. ncbi Early-onset infections of very-low-birth-weight infants in Polish neonatal intensive care units
    Jadwiga Wójkowska-Mach
    Microbiology, Jagiellonian University Medical College, Krakow, Poland
    Pediatr Infect Dis J 31:691-5. 2012
    ..The objective of this study was to investigate the incidence, causes, the risk factors, etiologic agents and the outcomes of early-onset infections (EOIs) in very-low-birth-weight newborns in Polish neonatal intensive care units...
  66. ncbi Procalcitonin behaves as a fast responding acute phase protein in vivo and in vitro
    M W Nijsten
    Department of Surgery, University Hospital Groningen, and the Groningen Institute for Drug Studies, The Netherlands
    Crit Care Med 28:458-61. 2000
    ..The source of production and its mechanism of induction are unknown. We investigated the inducibility of PCT both in vivo and in vitro and compared the behavior of PCT with those of SAA and CRP...
  67. pmc Rapid 16S rRNA next-generation sequencing of polymicrobial clinical samples for diagnosis of complex bacterial infections
    Stephen J Salipante
    Department of Laboratory Medicine, University of Washington, Seattle, Washington, USA
    PLoS ONE 8:e65226. 2013
    ..The described method is sufficiently rapid (theoretically compatible with same-day turnaround times) and inexpensive for routine clinical use...
  68. ncbi The complex interplay between stress and bacterial infections in animals
    Elin Verbrugghe
    University of Ghent, Faculty of Veterinary Medicine, Department of Pathology, Bacteriology and Avian Diseases, Salisburylaan 133, 9820 Merelbeke, Belgium
    Vet Microbiol 155:115-27. 2012
    ..In this manuscript an overview of how and when stress influences the outcome of bacterial infections in animals is provided.
  69. ncbi Consensus review of the epidemiology and appropriate antimicrobial therapy of complicated urinary tract infections in Asia-Pacific region
    Po Ren Hsueh
    Departments of Laboratory Medicine and Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan
    J Infect 63:114-23. 2011
    ..Because of considerable variability in different countries, local epidemiological data is critical in the effective management of UTIs in the Asia-Pacific region...
  70. ncbi Are pleuromutilin antibiotics finally fit for human use?
    Rodger Novak
    Nabriva Therapeutics AG, Vienna, Austria
    Ann N Y Acad Sci 1241:71-81. 2011
    ..This review will discuss key aspects of this antibacterial class and provide some insight into the question of why it took half a century to develop a systemic pleuromutilin for human use...
  71. ncbi Clinical impact of cycling the administration of antibiotics for febrile neutropenia in Japanese patients with hematological malignancy
    S Hashino
    Department of Gastroenterology and Hematology, Hokkaido University Graduate School of Medicine, Kita 15 Nishi 7, Kita ku, Sapporo 060 8638, Japan
    Eur J Clin Microbiol Infect Dis 31:173-8. 2012
    ..We conclude that cycling the administration of antibiotics in patients with FN is useful for suppressing the appearance of multi-drug-resistant bacteria and for obtaining excellent clinical efficacy...
  72. pmc Ion mobility spectrometry for microbial volatile organic compounds: a new identification tool for human pathogenic bacteria
    Melanie Jünger
    Department of Anesthesiology, Emergency and Intensive Care Medicine, University of Gottingen, Gottingen, Germany
    Appl Microbiol Biotechnol 93:2603-14. 2012
    ..In a hospital routine, this method could enable the identification of pathogens already after 24 h with the consequence that a specific therapy could be initiated significantly earlier...
  73. ncbi Cytosolic phospholipase A2 as a mediator of disease pathogenesis
    Amanda Linkous
    Neuro Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Cell Microbiol 12:1369-77. 2010
    ..This review briefly discusses the role of cPLA(2) in the biological response to disease-causing pathogens and injury, the immunological process and tumour progression...
  74. pmc Use of plasma C-reactive protein, procalcitonin, neutrophils, macrophage migration inhibitory factor, soluble urokinase-type plasminogen activator receptor, and soluble triggering receptor expressed on myeloid cells-1 in combination to diagnose infections
    Kristian Kofoed
    Clinical Research Unit, Copenhagen University Hospital, Hvidovre, Kettegaard Alle 30, DK 2650 Hvidovre, Denmark
    Crit Care 11:R38. 2007
    Accurate and timely diagnosis of community-acquired bacterial infections in patients with systemic inflammation remains challenging both for clinician and laboratory...
  75. ncbi International variations in infection supportive care practices for paediatric patients with acute myeloid leukaemia
    Thomas Lehrnbecher
    Paediatric Haematology and Oncology, University of Frankfurt, Frankfurt, Germany
    Br J Haematol 147:125-8. 2009
    ..0%, P = 0.03). There were systematic differences in infection-related supportive care practices. This information may be used to encourage harmonization of supportive care practices and future randomized trials...
  76. ncbi Scottish Antimicrobial Prescribing Group (SAPG): development and impact of the Scottish National Antimicrobial Stewardship Programme
    Dilip Nathwani
    Infection Unit, East Block, Level 4, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
    Int J Antimicrob Agents 38:16-26. 2011
    ....
  77. ncbi Molecular diagnostics and personalised medicine in wound care: assessment of outcomes
    S E Dowd
    Research and Testing Laboratory and Pathogenius Diagnostics, Lubbock, TX, USA
    J Wound Care 20:232, 234-9. 2011
    ....
  78. ncbi Biofilms and bacterial imbalances in chronic wounds: anti-Koch
    Steven L Percival
    Advanced Medical Solutions, Winsford Industrial Estate, Cheshire, UK
    Int Wound J 7:169-75. 2010
    ..We also present two possible hypotheses which could explain the role microorganisms play in non healing chronic wounds and offer possible strategies for combating harmful and detrimental biofilms...
  79. pmc Infectious diseases in patients with IRAK-4, MyD88, NEMO, or IκBα deficiency
    Capucine Picard
    Study Center of Primary Immunodeficiencies, Assistance Publique Hoˆpitaux de Paris, Necker Hospital, France
    Clin Microbiol Rev 24:490-7. 2011
    ..These disorders were initially thought to be rare but have now been diagnosed in over 170 patients worldwide. We review here the infectious diseases affecting patients with inborn errors of NF-κB-dependent TLR and IL-1R immunity...
  80. pmc A recessive mutation, immune deficiency (imd), defines two distinct control pathways in the Drosophila host defense
    B Lemaitre
    Institut de Biologie Moleculaire et Cellulaire, Unité Propre de Recherche 9022 du Centre National de la Recherche Scientifique, Strasbourg, France
    Proc Natl Acad Sci U S A 92:9465-9. 1995
    ..These results point to the existence of two different pathways leading to the expression of two types of target genes, encoding either the antibacterial peptides or the antifungal peptide drosomycin...
  81. ncbi Efficacy, safety, and pharmacokinetics of a 10% liquid immune globulin preparation (GAMMAGARD LIQUID, 10%) administered subcutaneously in subjects with primary immunodeficiency disease
    Richard L Wasserman
    Pediatrics Allergy Immunology Assoc, PA, Dallas, TX 75230, USA
    J Clin Immunol 31:323-31. 2011
    ..The overall infection rate during subcutaneous treatment was 4.1 per subject-year. Three acute serious bacterial infections were reported, resulting in a rate of 0.067 per subject-year...
  82. ncbi Fibrinolysis and host response in bacterial infections
    Simone Bergmann
    Max von Pettenkofer Institute, Ludwig Maximilians University of Munich, Munich, Germany
    Thromb Haemost 98:512-20. 2007
    ..Moreover, the role of factors of the fibrinolytic cascade in inflammatory host response due to different bacterial infections will be presented.
  83. pmc Malnutrition and gastrointestinal and respiratory infections in children: a public health problem
    Leonor Rodríguez
    Departamento de Ciencias de la Salud, Universidad Autonoma Metropolitana Iztapalapa, Avenida San Rafael Atlixco 186, CP 09340, Mexico, DF, Mexico
    Int J Environ Res Public Health 8:1174-205. 2011
    ..The consequences of malnutrition are diverse and included: increased susceptibility to infection, impaired child development, increased mortality rate and individuals who come to function in suboptimal ways...
  84. pmc DNA vaccines for targeting bacterial infections
    Mariana Ingolotti
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Expert Rev Vaccines 9:747-63. 2010
    ..Although few DNA vaccines against bacterial infections have been tested, the results are encouraging...
  85. pmc Immunopathogenesis of polymicrobial otitis media
    Lauren O Bakaletz
    The Research Institute at Nationwide Children s Hospital, Center for Microbial Pathogenesis, The Ohio State University College of Medicine, Columbus, OH 43205 2696, USA
    J Leukoc Biol 87:213-22. 2010
    ....
  86. ncbi Bacteriophages: an appraisal of their role in the treatment of bacterial infections
    Geoffrey William Hanlon
    School of Pharmacy and Biomolecular Sciences, University of Brighton, Moulsecoomb, Brighton BN2 4GJ, UK
    Int J Antimicrob Agents 30:118-28. 2007
    Bacteriophages were first used successfully to treat bacterial infections a decade before penicillin was discovered...
  87. ncbi Efficacy, pharmacokinetics, safety, and tolerability of Flebogamma 10% DIF, a high-purity human intravenous immunoglobulin, in primary immunodeficiency
    Melvin Berger
    Case Western Reserve University, Cleveland, OH, USA
    J Clin Immunol 30:321-9. 2010
    ..Pathogen safety is enhanced by the combination of multiple methods with different mechanisms of action...
  88. pmc Molecular analysis of volatile metabolites released specifically by Staphylococcus aureus and Pseudomonas aeruginosa
    Wojciech Filipiak
    Breath Research Institute of the Austrian Academy of Sciences, Rathausplatz 4, A 6850, Dornbirn, Austria
    BMC Microbiol 12:113. 2012
    ..e. Staphylococcus aureus and Pseudomonas aeruginosa, were performed to investigate the release or consumption of volatile organic compounds (VOCs)...
  89. ncbi Antiviral therapy increases the risk of bacterial infections in HCV-infected cirrhotic patients awaiting liver transplantation: A retrospective study
    José A Carrión
    Liver Unit, Institut de Malalties Digestives, Hospital Clinic, Ciberehd and IDIBAPS, University of Barcelona, Villarroel 170, 08036 Barcelona, Spain
    J Hepatol 50:719-28. 2009
    ..Recurrence of hepatitis C after liver transplantation (LT) is universal and may cause premature graft loss. We evaluated the efficacy and safety of antiviral therapy in HCV-infected patients with decompensated cirrhosis awaiting LT...
  90. ncbi Novel Chlamydiales associated with epitheliocystis in a leopard shark Triakis semifasciata
    A Polkinghorne
    Institute of Veterinary Pathology, University of Zurich, Winterthurerstrasse 268, Zurich 8057, Switzerland
    Dis Aquat Organ 91:75-81. 2010
    ..A greater understanding of the genetic diversity of marine Chlamydiales will assist our attempts to manage and control epitheliocystis outbreaks and to understand the evolution of this unique obligate intracellular pathogen...
  91. ncbi Preventive antibiotics for infections in acute stroke: a systematic review and meta-analysis
    Diederik van de Beek
    Department of Neurology, Center of Infection and Immunity Amsterdam CINIMA, Academic Medical Center, Amsterdam, The Netherlands
    Arch Neurol 66:1076-81. 2009
    ..To provide a systematic overview and meta-analysis of randomized clinical trials evaluating preventive antibiotics in patients with acute stroke...
  92. ncbi Prevalence of nosocomial infections in The Netherlands, 2007-2008: results of the first four national studies
    T I I van der Kooi
    RIVM National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    J Hosp Infect 75:168-72. 2010
    ..The use of antibiotics as well as medical devices differed considerably between hospitals. Both the prevalence of NI in The Netherlands and the use of antibiotics and devices were comparable to other European countries...
  93. ncbi The expansion of the microbiological spectrum of brain abscesses with use of multiple 16S ribosomal DNA sequencing
    Mouhamad Al Masalma
    Pôle des Maladies Infectieuses, Assistance Publique Hôpitaux de Marseille and URMITE, Centre National de la Recherche Scientifique, Unite Mixte de Recherche 6236, Institut pour la Recherche et le Développement 198, Universite de la Mediterranee, France
    Clin Infect Dis 48:1169-78. 2009
    ..Mycoplasma species are common and should be detected in this situation. These findings led us to question the accuracy of the current empirical treatment of brain abscess...
  94. ncbi Levofloxacin: a review of its use in the treatment of bacterial infections in the United States
    Katherine F Croom
    Adis International Limited, Auckland, New Zealand
    Drugs 63:2769-802. 2003
    ....
  95. ncbi International Nosocomial Infection Control Consortium (INICC) report, data summary for 2003-2008, issued June 2009
    Victor D Rosenthal
    International Nosocomial Infection Control Consortium, Buenos Aires, Argentina
    Am J Infect Control 38:95-104.e2. 2010
    ..0% vs 20.2%, respectively) were also far higher in the consortium's ICUs, and the crude unadjusted excess mortalities of device-related infections ranged from 23.6% (CVC-associated bloodstream infections) to 29.3% (VAP)...
  96. ncbi Procalcitonin and C-reactive protein as diagnostic markers of severe bacterial infections in febrile infants and children in the emergency department
    Barbara Andreola
    Department of Pediatrics, University of Padova, Italy
    Pediatr Infect Dis J 26:672-7. 2007
    ..PCT) and C-reactive protein (CRP), compared with that of total white-blood cell count (WBC) and absolute neutrophil count (ANC), in predicting severe bacterial infections (SBIs) in febrile children admitted to Emergency Department.
  97. ncbi Beta-lactams and beta-lactamase-inhibitors in current- or potential-clinical practice: a comprehensive update
    M Shahid
    Section of Antimicrobial Resistance Researches and Molecular Biology, Department of Microbiology, Jawaharlal Nehru Medical College and Hospital, Aligarh Muslim University, Aligarh 202002, Uttar Pradesh, India
    Crit Rev Microbiol 35:81-108. 2009
    ..This review will fill the gap since previously published reviews and will serve as a comprehensive update on the current topic...
  98. ncbi Infections in patients with multiple myeloma in the era of high-dose therapy and novel agents
    Marcio Nucci
    University Hospital, Universidade Federal do Rio de Janeiro, Brazil
    Clin Infect Dis 49:1211-25. 2009
    ....
  99. ncbi A pilot study of antibiotic cycling in the community hospital setting
    Lou Ann Bruno-Murtha
    Department of Medicine, Cambridge Health Alliance Harvard Medical School, Cambridge, Massachusetts, USA
    Infect Control Hosp Epidemiol 26:81-7. 2005
    ..To assess the feasibility of a quarterly antibiotic cycling program at two community hospitals and to evaluate its safety and impact on antibiotic use, expenditures, and resistance...
  100. ncbi Synthetic cationic peptide IDR-1002 provides protection against bacterial infections through chemokine induction and enhanced leukocyte recruitment
    Anastasia Nijnik
    Department of Microbiology and Immunology, Centre for Microbial Diseases and Immunity Research, University of British Columbia, Vancouver, British Columbia, Canada
    J Immunol 184:2539-50. 2010
    ....
  101. ncbi Recurrent postnatal infections are associated with progressive white matter injury in premature infants
    Hannah C Glass
    Department of Neurology, University of California, San Francisco, USA
    Pediatrics 122:299-305. 2008
    ..Our objective was to identify clinical predictors of progressive white matter injury...

Research Grants81

  1. MOLECULAR MECHANISMS OF SEPTIC SHOCK
    JACK HAWIGER; Fiscal Year: 2003
    ..In many cases these bacterial infections occur in the setting of indwelling catheters coated with bacterial biofilms following their insertion for ..
  2. Periodontal Biomaterials with BITE (Biofilm Immunity via T-cell Enhancement)
    James D Bryers; Fiscal Year: 2012
    ..Our goal is to develop tissue regenerative biomaterials that will also provide a short-term defense and life long immune response to specific bacterial infections
  3. Optimized Growth Media to Detect Intracellular Bacteria Implicated in Chronic Dis
    PATRICIA MASCARELLI; Fiscal Year: 2011
    ..Traditional methods for detecting bacterial infections in patient samples have proven to be largely ineffective for the accurate diagnosis of Bartonellosis...
  4. Targeting superbugs: discovery and development of new broad-spectrum lipopeptides
    Jian Li; Fiscal Year: 2013
    ..There simply aren't enough new drugs in the pharmaceutical pipeline to keep pace with drug-resistant bacterial infections, so-called 'superbugs'...
  5. Fatty acid related regulation of enteric infectious disease
    FREDRICK JON KULL; Fiscal Year: 2012
    ..pathogenic activity, thereby laying the groundwork for development of therapeutics that could be broadly applied to treat enteric bacterial infections causing diseases such as travelers'diarrhea, dysentery, and typhoid fever.
  6. Characterizing TLR Function of Human Dendritic Cells in the Elderly
    Alexander Panda; Fiscal Year: 2012
    ..decline in immune function (immunosenescence) resulting in increased susceptibility to viral and bacterial infections and decreased response to vaccines...
  7. Mucosal Memory T Cells at the Vanguard of Human Host Defense
    Donna L Farber; Fiscal Year: 2010
    ..and intestinal pathogens such as influenza, respiratory syncytical virus (RSV), rotavirus and numerous bacterial infections that pose substantial threats to world health...
  8. The Electricidal Effect, a Novel Anti-Biofilm Strategy
    Robin Patel; Fiscal Year: 2013
    ..and supporting data for the use of the electricidal effect for prevention and treatment of device-related bacterial infections in humans...
  9. Anti-Bacterial Innate Responses Enhance Paramyxovirus Replication
    Griffith D Parks; Fiscal Year: 2010
    ..Thus, there is a gap in our understanding of interactions between viral and bacterial infections as well as the impact of these microbes on immune responses...
  10. Role of the neurogenic inflammatory pathway in the genital tract immune response
    Roger G Rank; Fiscal Year: 2010
    ..It has been well known that these molecules can initiate an inflammatory response, but their role in bacterial infections at mucosal surfaces has not been addressed to a great extent...
  11. Insights from Comparative Genomics for the Treatment of Pneumococcal Infections
    Natalia Luisa Hiller; Fiscal Year: 2011
    ..is responsible for the major paradigm shift that states that culture-negative, antibiotic-resistant chronic bacterial infections result from a metabolic change from a planktonic to a biofilm form...
  12. Epidemiology and Etiology of Hospitalized Pneumonia in Children
    Krow Ampofo; Fiscal Year: 2010
    ..Understanding the frequency and etiology of bacterial infections following influenza will aid in pandemic planning...
  13. Therapeutics for Drug-Resistant Bacteria: Myxopyronins
    Richard H Ebright; Fiscal Year: 2013
    ..Drug-resistant bacterial infections are a major and growing threat...
  14. Insights from Comparative Genomics for the Treatment of Pneumococcal Infections
    Natalia Luisa Hiller; Fiscal Year: 2013
    ..is responsible for the major paradigm shift that states that culture-negative, antibiotic-resistant chronic bacterial infections result from a metabolic change from a planktonic to a biofilm form...
  15. OmpR and SsrB Regulation of Salmonella Virulence
    Linda J Kenney; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: Impact on Veteran's Health Veterans suffer from both acute and chronic bacterial infections. Our studies are mechanistic and have implications beyond Salmonella, extending to other pathogens...
  16. Localization and characterization of the Clostridium difficile biofilm
    Adam Driks; Fiscal Year: 2013
    ..A critical early step in many bacterial infections is attachment to specific host tissues, which guards against host defenses that may remove or kill the ..
  17. Fic-mediated Adenylylation
    CAROLYN ANN WORBY; Fiscal Year: 2013
    ..This covalent addition of AMP blocks signal transduction pathways in the host that are important for combating bacterial infections.
  18. Recombinant hepatic argininosuccinate synthase (rASS) for treatment of sepsis/end
    Stanislav I Svetlov; Fiscal Year: 2012
    ..result in significant morbidity and mortality, especially in pediatric and elderly patients with severe bacterial infections. Pathogenesis of endotoxic shock/sepsis has not been understood in great detail, moreover its therapy, ..
  19. A common denominator of pathogenesis;a rare opportunity for novel therapeutic de
    DOUGLAS ALAN MITCHELL; Fiscal Year: 2011
    ..Perhaps most important were the discovery of antibiotics for bacterial infections and effective vaccines for several major viruses...
  20. Group B. Streptococci and Toll-like Receptors
    Douglas T Golenbock; Fiscal Year: 2012
    ..of these studies will allow us to understand how Group B streptococcus, a leading cause of severe bacterial infections in newborn infants, is recognized by the immune system...
  21. Developing a New Antioxidant Activator to Intervene in Lung Inflammatory Diseases
    JOHN WILLIMANN; Fiscal Year: 2009
    ..S. These diseases include allergic asthma, chronic obstructive pulmonary disease, viral and bacterial infections, and related sepsis-induced acute lung injury...
  22. Disease-related defects in dendritic cell processing of bacterial antigens
    Michael S Marks; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Bacterial infections are largely cleared by phagocytosis within specialized phagocytic cell types...
  23. Rapid, Highly Multiplexed and Sensitive Blood Test for Drug-resistant Bacteria
    ARMIN H REITMAIR; Fiscal Year: 2010
    ..quantitative, cost-effective, and fully automated, nucleic acid- and protein-based diagnostic system for bacterial infections, to allow quick and accurate pathogen identification in clinical samples, including acquired genetic traits ..
  24. Novel immunotherapeutics for the management of otitis media due to H. influenzae
    Steven D Goodman; Fiscal Year: 2013
    ..will continue our long-standing efforts to "explore the pathogenesis, treatment and prevention of viral and bacterial infections that contribute to communication disorders" (i.e...
  25. Reciprocal Control of Motility and Adherence in UTI
    Harry L Mobley; Fiscal Year: 2013
    ..Indeed, urinary tract infection is one of the most common bacterial infections of humans and the most common kidney and urologic disease in the US...
  26. MECHANISM AND CONTROL OF UREA BIOSYNTHESIS
    Frank M Raushel; Fiscal Year: 2011
    ..These studies may lead to the development of new antibiotics in the defense of bacterial infections.
  27. National surveillance of emerging MDR in pediatric Enterobacteriaceae infections
    Danielle M Zerr; Fiscal Year: 2013
    ..This information has the potential to inform treatment, especially empiric treatment, of serious bacterial infections in children...
  28. Biofilm matrix-degrading enzymes for the treatment and prevention of S. aureus-as
    Jeffrey B Kaplan; Fiscal Year: 2013
    ..Project Narrative Bacterial infections are a serious complication of wound injuries...
  29. Exploiting deep ocean biology for biomedical discovery
    David C Rowley; Fiscal Year: 2011
    ..goal of the project is the discovery of new antimicrobial agents useful in the treatment of drug-resistant bacterial infections. Our ability to treat infectious disease is increasingly compromised by the emergence of drug-resistant ..
  30. Antifibrotic Therapy to Improve Immune reconstitution in HIV
    Timothy W Schacker; Fiscal Year: 2013
    ..function among people treated with antiretroviral therapy including poor vaccine responsiveness, increased bacterial infections, and poor control of mucosal pathogens like human papilloma virus and herpes simplex virus...
  31. NICHD INTERNATIONAL & DOMESTIC PEDIATRIC &MATERNAL HIV STUDIES COORDINATING CTR
    CAROL NESEL; Fiscal Year: 2013
    ..to conduct a single clinical trial evaluating the use of intravenous immunoglobulin (IVIG) prophylaxis for bacterial infections in 376 HIV-infected children...
  32. Cell wall synthesis enzymes and beta-lactam resistance in Enterococcus faecium
    Louis B Rice; Fiscal Year: 2013
    ..High-level ? lactam resistance expressed by E. faecium not only compromises therapy of bacterial infections, it promotes gastrointestinal colonization and further dissemination of resistant strains...
  33. MECHANISM OF PATHOGENIC ACTIVITY OF PEPTIDOGLYCAN
    Roman Dziarski; Fiscal Year: 2012
    b>Bacterial infections are still the major cause of morbidity and mortality, and innate immunity is the first line of host defense against infections...
  34. Research and Development of a Novel System to Produce Polysaccharide Conjugate Va
    Peng George Wang; Fiscal Year: 2013
    ..Polysaccharides (PSs) of bacteria have great potentials to be used as vaccines for preventing bacterial infections. Although traditional chemical conjugation of polysaccharides with carrier proteins to make PS-protein ..
  35. Re-Wiring Cellular Metabolism to Control Biofilm Formation and Virulence BY...
    Thomas K Wood; Fiscal Year: 2011
    ..If virulence genes can also be controlled in biofilms, then novel treatments can be envisioned for the 80% of bacterial infections that occur in biofilms where antibiotics are often ineffective.
  36. Mechanism of Bach1-Mediated Transcriptional Regulation and Immune Function
    David Baltimore; Fiscal Year: 2013
    ..2) Second, the role of Bach1 during viral and bacterial infections will be determined...
  37. Functional genomics of human variation to Salmonella invasion
    DENNIS CHUN YONE KO; Fiscal Year: 2013
    ..Dennis Ko, is to determine the genetic basis for differences in susceptibility to bacterial infections. This knowledge is important for determining why some individuals are resistant to different infections and ..
  38. Genes Mediating Innate Immune Suppression by Hypercapnia in Mammals and Flies
    PETER H SPORN; Fiscal Year: 2013
    ..genes required for host defense in human, mouse and Drosophila cells, and increases mortality due to bacterial infections in mice and Drosophila...
  39. Role of Protein Kinase C in Macrophage Activation
    Michelle R Lennartz; Fiscal Year: 2012
    ..Mice lacking protein kinase C-epsilon (PKC-e) are highly susceptible to bacterial infections and fail to mount an effective inflammatory response...
  40. Molecular Basis of Bacterial Quorum Sensing Gene Regulation
    MAIR E CHURCHILL; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: Current treatments of gram-negative bacterial infections will be greatly improved when the formation of bacterial biofilms and production of virulence factors can ..
  41. Genetics and Genomics of the yidC paralogs in Streptococcus mutans
    SARA MARIE RASER PALMER; Fiscal Year: 2013
    ..The data generated will provide essential new information that can be used to design novel and more effective therapies to combat dental caries and other bacterial infections.
  42. Modular Subunit Vaccine for Salmonella
    MARC KEVIN JENKINS; Fiscal Year: 2011
    ..anatomically confined chronic infection is the best way to generate multifunctional Th1 cells capable of controlling intracellular bacterial infections and because it will be pursued with novel T cell tracking technology.
  43. Microenvironmental changes on NK cell responses to primary HSV-1
    Andrew J Tarr; Fiscal Year: 2011
    ..e., social disruption stress) innate immunity can be enhanced to both viral and bacterial infections. Natural killer (NK) cells are innate- lymphocytes that are known to be potent mediators of anti-HSV-1 ..
  44. SPLUNC1 protein in host defense against Mycoplasma pneumoniae infection
    HONG W CHU; Fiscal Year: 2012
    ..To date, the mechanisms by which asthmatics are susceptible to bacterial infections are largely unknown. Airway epithelial cells are critical in host defense against the invading pathogens...
  45. Diphthamide biosynthesis
    Hening Lin; Fiscal Year: 2012
    ..During certain bacterial infections, this modified residue (but not the unmodified histidine residue) is specifically recognized by bacterial ..
  46. CYTOTOXIC RESPONSE TO HISTOCOMPATIBILITY ANTIGENS
    Michael J Bevan; Fiscal Year: 2012
    ..Subsets of T lymphocytes, helpers and killers, must cooperate to achieve protection against many viral and bacterial infections. Our research will shed light on this cooperation for the promotion of long-lived protective immunity...
  47. Gene Targeted Therapy of Brain Tumors
    John H Sampson; Fiscal Year: 2010
    ..This is not much different than in other biologic systems, for example AIDS, leukemia, or bacterial infections, where the potency of combinatorial therapy has been evident in many early and dramatic treatment successes...
  48. C. trachomatis-mediated signaling pathways required for Type I IFN responses
    JEFFREY RYAN BARKER; Fiscal Year: 2013
    ..The exact role Type I IFNs play in the outcome of bacterial infections remains unclear as these cytokines can both prevent and enhance pathogen replication...
  49. The Role of PtdIns-5-P in Cell Function and Signaling
    LUCIA RAMEH-PLANT; Fiscal Year: 2012
    ..Our aim is to understand the function of this lipid under physiological and pathological conditions, with the goal of designing new strategies to prevent and treat diseases such as diabetes and bacterial infections.
  50. Augmentation of Innate Anti-Microbial Immunity by TLR4 Agonists
    Edward R Sherwood; Fiscal Year: 2013
    ..However, the mechanisms by which MPLA augments the host response to systemic bacterial infections are not well understood and further work is needed to translate the use of MPLA in high risk patients to ..
  51. Role of influenza-induced prothrombosis in Streptococcus pyogenes superinfections
    Michael S Chaussee; Fiscal Year: 2012
    ..virus poses a significant annual global health threat, especially when they are complicated by secondary bacterial infections. During the recent H1N1 pandemic, S...
  52. Fibronectin-binding Protein of Treponema Denticola in Periodontal Disease
    Xiaoping Xu; Fiscal Year: 2012
    ..denticola to periodontal tissues and to characterize the biological function of the FbpA protein family in order to provide new strategies to prevent bacterial infections.
  53. A novel Salmonella vaccine to protect against extra intestinal pathogenic E. coli
    Melha Mellata; Fiscal Year: 2011
    ..of this system are very encouraging and suggest the success of using attenuated Salmonella to prevent bacterial infections;however more studies are needed to increase both the safety and efficacy of the treatment in humans...
  54. Validating metabolic pathways in the intracellular pathogen Chlamydia trachomatis
    DEREK JAMES FISHER; Fiscal Year: 2010
    ..Chlamydia is the number one cause of bacterial infections in the United States and the leading cause of blindness and bacterial STD worldwide...
  55. Structure and Function of Endothelial Fenestrae
    RADU VIRGIL STAN; Fiscal Year: 2010
    ..of several human diseases such as tumor angiogenesis, acute and chronic inflammation (both viral and bacterial infections, transplant rejection, allergic encephalomyelytis, Alzheimer disease), atherosclerosis, preeclampsia, toxic ..
  56. RENAL FUNCTION AND DISEASE
    Bruce A Stanton; Fiscal Year: 2013
    ..S. In addition, bacterial infections of the kidney and lung produce significant morbidity and mortality in the U.S...
  57. Bordetella Biofilms and Pathogenesis
    RAJENDAR K DEORA; Fiscal Year: 2011
    ..coli and Yersinia Spp, and possibly others, our results will contribute towards the treatment and the understanding of a wide variety of bacterial infections.
  58. Structural Biology of Enterotoxin Secretion from Bacterial Cells
    WILHELMUS G J HOL; Fiscal Year: 2013
    ..At the same time, our structural data will provide a new basis for developing future therapeutic interventions against bacterial infections.
  59. Pneumococcal capsule and host innate immunity
    Moon H Nahm; Fiscal Year: 2012
    ..in many different pneumococcal serotypes and because very little is known about L-ficolin's role in bacterial infections. Our work is also directly relevant to pneumococcal vaccin development because 11A has become one of the ..
  60. Synthetic saccharides to study immunological properties of Streptococcus pneumoni
    Alexei V Demchenko; Fiscal Year: 2010
    ..Amongst over ninety elucidated SPn serotypes, 6A and 6B are nearly equally important causes of bacterial infections. Serotypes SPn6A and 6B account for 4...
  61. The Mycobacterium Tuberculosis Dormancy Program
    MARTIN INUA VOSKUIL; Fiscal Year: 2013
    ..In addition, tuberculosis is one of the most difficult bacterial infections to treat and continues to cause more deaths than any other bacterial infection...
  62. An Integrated Diagnostic System for Rapid Antimicrobial Susceptibility Testing
    VINCENT JEN JR GAU; Fiscal Year: 2013
    ..clinicians to direct point-of-care (POC), evidence-based selection of antibiotics for treatment of acute bacterial infections. RAST addresses the major limitations of standard phenotypic AST platforms (e.g...
  63. Broad-Spectrum Antimicrobials Targeting the D-Alanine Pathway
    KAREN G ANTHONY; Fiscal Year: 2013
    ..See instructions): The long-term product goal of this project is a broad-spectrum therapeutic to treat bacterial infections of public health and biodefense importance...
  64. Bacteriolytic phage enzymes as novel antibacterials against Yersinia pestis
    Ian Molineux; Fiscal Year: 2009
    ..Phage-encoded bacteriolytic enzymes are promising reagents to treat a wide range of bacterial infections because their mechanisms of action are different from those of antibiotics...
  65. EFFECT OF CRANBERRY CONSTITUENTS ON UTI PATHOGENESIS
    Scott Hultgren; Fiscal Year: 2007
    Urinary tract infections (UTIs) are among the most common bacterial infections, with symptoms that can include dysuria, urgency and frequency of urination, flank pain and fever...
  66. Protective Role of Interleukin 10 in Neuroborreliosis
    Diego Cadavid; Fiscal Year: 2009
    b>Bacterial infections of the central nervous system (CNS) are an important cause of morbidity and mortality...
  67. ARF BINDING IN THE ACTION OF CHOLERA AND E COLI TOXINS
    Richard Kahn; Fiscal Year: 2002
    ..Both cholera and the less virulent "travelers diarrhea" result from bacterial infections (by Vibrio cholerae and E...
  68. Diet and the Calcium Channel TRPV6 in Colon Hyperplasia
    Sara Peleg; Fiscal Year: 2010
    ..These factors combine to compromise the innate immunity of the gut and to increase the susceptibility to bacterial infections and chronic inflammation...
  69. Phase 2 Pharmacodynamic Study of High-dose Levofloxacin in MDR-TB Treatment
    C Robert Horsburgh; Fiscal Year: 2010
    ..Maximizing AUC/MIC ratio is likely to lead to optimal antimycobacterial effect, as it does in serious bacterial infections. The investigators, Drs...
  70. Pheresis Treatment of Bioterrorism-Induced Sepsis
    Stephen Ash; Fiscal Year: 2005
    ..can also induce Systemic Inflammatory Response Syndrome (SIRS) and septic shock because of secondary bacterial infections. An effective therapy for SIRS and MODS would spare many of the victims of bioterrorism from a tragic death...
  71. Chronic alcohol and pulmonary immunity
    Kevin L Legge; Fiscal Year: 2010
    ..While much is known about the role that chronic alcohol plays in increasing the severity of respiratory bacterial infections, much less is understood about how chronic ethanol (EtOH) consumption alters the severity of pulmonary ..
  72. E COLI TRANSLOCATION ACROSS INTESTINAL EPITHELIUM
    Michelle Pietzak; Fiscal Year: 2003
    ..E. coli is a leading cause of severe bacterial infections in premature infants, neonates, immunocompromised hosts, and children with central lines and primary ..
  73. Functional similarities in renal and cochlear epithelia
    PETER STEYGER; Fiscal Year: 2004
    Aminoglycosides are clinically essential for treating life-threatening Gram-negative bacterial infections, e.g., meningitis, and in preventing infection in burns and premature babies...
  74. DNA Repair Defects in IgA Deficiency
    REUBEN HARRIS; Fiscal Year: 2009
    ..in humans, and it is characterized by the absence of serum IgA and an increased frequency of bacterial infections in the respiratory and gastrointestinal tracts...
  75. THE EFFICACY OF CONJUGATE VACCINES AGAINST H INFLUENZAE
    Eugene Shapiro; Fiscal Year: 1993
    Haemophilus influenzae type b is the most common cause of bacterial meningitis and other serious invasive bacterial infections in children...
  76. Antibiotic Potentiators Targeting SOS Induction
    Timothy Opperman; Fiscal Year: 2009
    ..This approach represents an innovation in the way bacterial infections will be treated...
  77. PROOF OF CONCEPT FOR ANTIMICROBIAL PROPERTIES OF LACRITIN IN VIVO
    John D Sheppard; Fiscal Year: 2010
    ..the past sixty years, antibiotics have comprised a key component in both the treatment and prophylaxis of bacterial infections. Since that time the continuous development of new antibiotics has been necessary to limit toxicity, ..
  78. ACTIVATION OF PERIODONTAL FIBROBLASTS VIA CD40
    Timothy Blieden; Fiscal Year: 2000
    Periodontal bacterial infections induce chronic inflammation which leads to a massive infiltration of acute and chronic inflammatory cells...
  79. Production of Polysaccharide-Protein Conjugates as Vaccines
    Wen Yi; Fiscal Year: 2009
    ..coli O157. Bacterial infections constitute one of the major health problems worldwide...
  80. A novel model for the study of primary immunodeficiency: the equine CVID
    MARIA FLAMINIO; Fiscal Year: 2009
    ..characterized by late-onset B cell lymphopenia or depletion, hypo- or agammaglobulinemia, and recurrent bacterial infections. Although these equine patients do not respond to tetanus-toxoid vaccination with specific-immunoglobulin ..
  81. Biofilm Formation And P. aeruginosa infection of the eye
    Michael Zegans; Fiscal Year: 2006
    DESCRIPTION: (Applicant's Abstract) Bacterial infections of the eye can have vision-threatening complications and often are associated with prosthetic devices such as contact lenses, scleral buckles, and intraocular lenses...