monkey diseases

Summary

Summary: Diseases of Old World and New World monkeys. This term includes diseases of baboons but not of chimpanzees or gorillas (= APE DISEASES).

Top Publications

  1. ncbi A large focus of naturally acquired Plasmodium knowlesi infections in human beings
    Balbir Singh
    Faculty of Medicine and Health Sciences, Universiti Malaysia Sarawak, Kuching, Sarawak, Malaysia
    Lancet 363:1017-24. 2004
  2. pmc Cross-species transmission of a novel adenovirus associated with a fulminant pneumonia outbreak in a new world monkey colony
    Eunice C Chen
    Department of Laboratory Medicine, University of California San Francisco, San Francisco, California, United States of America
    PLoS Pathog 7:e1002155. 2011
  3. pmc Novel simian foamy virus infections from multiple monkey species in women from the Democratic Republic of Congo
    William M Switzer
    Division of HIV AIDS Prevention, National Center for HIV AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Retrovirology 9:100. 2012
  4. pmc The macaque gut microbiome in health, lentiviral infection, and chronic enterocolitis
    Philip McKenna
    Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
    PLoS Pathog 4:e20. 2008
  5. pmc Modes of transmission and genetic diversity of foamy viruses in a Macaca tonkeana colony
    Sara Calattini
    Unité d Epidémiologie et Physiopathologie des Virus Oncogènes, Departement de Virologie, Institut Pasteur, Paris, France
    Retrovirology 3:23. 2006
  6. ncbi Screening for simian foamy virus infection by using a combined antigen Western blot assay: evidence for a wide distribution among Old World primates and identification of four new divergent viruses
    Althaf I Hussain
    HIV and Retrovirology Branch, Division of AIDS, STD, and TB Laboratory Research, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Virology 309:248-57. 2003
  7. pmc Human Infections with Plasmodium knowlesi, the Philippines
    Jennifer Luchavez
    Research Institute for Tropical Medicine Parasitology, Fillinvest Compound, Alabang, Muntinlupa City, Muntinlupa 1781, The Philippines
    Emerg Infect Dis 14:811-3. 2008
  8. ncbi Natural infection with canine distemper virus in hand-feeding Rhesus monkeys in China
    Zhaozeng Sun
    Laboratory Animal Center of the Academy of Military Medical Science, No 20, Dongdajie Street, Fengtai District, Beijing 100071, China
    Vet Microbiol 141:374-8. 2010
  9. ncbi Treponema infection associated with genital ulceration in wild baboons
    S Knauf
    Justus Liebig University, Clinic for Obstetrics, Gynecology and Andrology of Large and Small Animals, Frankfurterstrasse 106, 35393 Giessen, Germany
    Vet Pathol 49:292-303. 2012
  10. ncbi Differential detection of B virus and rhesus cytomegalovirus in rhesus macaques
    J L Huff
    Department of Medical Microbiology and Immunology, University of California Davis, Davis, CA 95616, USA
    J Gen Virol 84:83-92. 2003

Research Grants

Detail Information

Publications195 found, 100 shown here

  1. ncbi A large focus of naturally acquired Plasmodium knowlesi infections in human beings
    Balbir Singh
    Faculty of Medicine and Health Sciences, Universiti Malaysia Sarawak, Kuching, Sarawak, Malaysia
    Lancet 363:1017-24. 2004
    ..We aimed to investigate whether such infections could be attributable to a variant form of P malariae or a newly emergent Plasmodium species...
  2. pmc Cross-species transmission of a novel adenovirus associated with a fulminant pneumonia outbreak in a new world monkey colony
    Eunice C Chen
    Department of Laboratory Medicine, University of California San Francisco, San Francisco, California, United States of America
    PLoS Pathog 7:e1002155. 2011
    ..The discovery of TMAdV, a novel adenovirus with the capacity to infect both monkeys and humans, suggests that adenoviruses should be monitored closely as potential causes of cross-species outbreaks...
  3. pmc Novel simian foamy virus infections from multiple monkey species in women from the Democratic Republic of Congo
    William M Switzer
    Division of HIV AIDS Prevention, National Center for HIV AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Retrovirology 9:100. 2012
    ..Phylogenetic analysis was used to define the NHP species origin of SFV. Participants completed questionnaires to capture NHP exposure information...
  4. pmc The macaque gut microbiome in health, lentiviral infection, and chronic enterocolitis
    Philip McKenna
    Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
    PLoS Pathog 4:e20. 2008
    ..This work provides comprehensive data and improved methods for studying the role of commensal microbiota in macaque models of GI diseases and provides a model for the large-scale screening of the human gut microbiome...
  5. pmc Modes of transmission and genetic diversity of foamy viruses in a Macaca tonkeana colony
    Sara Calattini
    Unité d Epidémiologie et Physiopathologie des Virus Oncogènes, Departement de Virologie, Institut Pasteur, Paris, France
    Retrovirology 3:23. 2006
    ....
  6. ncbi Screening for simian foamy virus infection by using a combined antigen Western blot assay: evidence for a wide distribution among Old World primates and identification of four new divergent viruses
    Althaf I Hussain
    HIV and Retrovirology Branch, Division of AIDS, STD, and TB Laboratory Research, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Virology 309:248-57. 2003
    ..These results demonstrate the ability of the CA-WB assay to detect infection in a large number of NHP species, including previously uncharacterized infections with divergent SFVs...
  7. pmc Human Infections with Plasmodium knowlesi, the Philippines
    Jennifer Luchavez
    Research Institute for Tropical Medicine Parasitology, Fillinvest Compound, Alabang, Muntinlupa City, Muntinlupa 1781, The Philippines
    Emerg Infect Dis 14:811-3. 2008
    ..This study suggests that this zoonotic infection is found across a relatively wide area in Palawan and documents autochthonous cases in the country...
  8. ncbi Natural infection with canine distemper virus in hand-feeding Rhesus monkeys in China
    Zhaozeng Sun
    Laboratory Animal Center of the Academy of Military Medical Science, No 20, Dongdajie Street, Fengtai District, Beijing 100071, China
    Vet Microbiol 141:374-8. 2010
    ..This is the first report we are aware of documenting Rhesus monkeys infected with CDV in China. Urgent work should be done to prevent the possibly epidemic of CDV in non-human primate...
  9. ncbi Treponema infection associated with genital ulceration in wild baboons
    S Knauf
    Justus Liebig University, Clinic for Obstetrics, Gynecology and Andrology of Large and Small Animals, Frankfurterstrasse 106, 35393 Giessen, Germany
    Vet Pathol 49:292-303. 2012
    ....
  10. ncbi Differential detection of B virus and rhesus cytomegalovirus in rhesus macaques
    J L Huff
    Department of Medical Microbiology and Immunology, University of California Davis, Davis, CA 95616, USA
    J Gen Virol 84:83-92. 2003
    ..Detection of B virus DNA shedding is a relatively rare event associated with the breeding season, while RhCMV DNA is persistently detected in mucosal fluids of most monkeys...
  11. ncbi Human infection with foamy viruses
    W Heneine
    HIV and Retrovirology Branch, Centers for Disease Control and Prevention, 1600 Clifton Road, Mail Stop G19, Atlanta, GA 30333, USA
    Curr Top Microbiol Immunol 277:181-96. 2003
    ..Additional studies are needed to better define the prevalence and natural history of SFV in humans...
  12. pmc Adenoviruses in fecal samples from asymptomatic rhesus macaques, United States
    Soumitra Roy
    Department of Pathology and Laboratory Medicine, Division of Transfusion Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Emerg Infect Dis 18:1081-8. 2012
    ..The high prevalence of adenoviruses in fecal samples from asymptomatic rhesus macaques and the similarity of the isolates to human strains indicates the possibility of animal-to-human transmission of SAdVs...
  13. ncbi Coprologic evidence of gastrointestinal helminths of forest baboons, Papio anubis, in Kibale National Park, Uganda
    Marisa Bezjian
    Department of Infectious Diseases and Pathology, College of Veterinary Medicine, University of Florida, Gainesville, Florida 32610, USA
    J Wildl Dis 44:878-87. 2008
    ..Strongyloides sp., and Trichostrongylus sp. The high prevalence of nematodes recovered in this study seems to support previous theories of high nematode infections in forested habits...
  14. ncbi A serological survey of Ebola virus infection in central African nonhuman primates
    E M Leroy
    Centre International de Recherches Medicales de Franceville, Institut de Recherche pour le Developpement, UR034, Franceville, Gabon
    J Infect Dis 190:1895-9. 2004
    ..They also suggest that future Ebola outbreaks may occur anywhere in the central African forest region...
  15. pmc Proteome-scale antibody responses and outcome of Mycobacterium tuberculosis infection in nonhuman primates and in tuberculosis patients
    Shajo Kunnath-Velayudhan
    Public Health Research Institute, New Jersey Medical School, 225 Warren St, Newark, New Jersey 07103, USA
    J Infect Dis 206:697-705. 2012
    ..We assessed correlations between infection outcome and antibody responses in macaques and humans by high-throughput, proteome-scale serological studies...
  16. pmc Recognition of ESAT-6 sequences by antibodies in sera of tuberculous nonhuman primates
    G V Kanaujia
    Public Health Research Institute, Newark, New Jersey Merck Research Laboratories, West Point, Pennsylvania Department of Comparative Medicine, Stanford University, Stanford, California Statens Serum Institute, Copenhagen, Denmark
    Clin Diagn Lab Immunol 11:222-6. 2004
    ..The data support use of synthetic peptides in lieu of the full-length ESAT-6 protein in diagnostic antibody detection assays...
  17. pmc Evolution of a TRIM5-CypA splice isoform in old world monkeys
    Ruchi M Newman
    Department of Microbiology and Molecular Genetics, New England Primate Research Center, Harvard Medical School, Southborough, Massachusetts, United States of America
    PLoS Pathog 4:e1000003. 2008
    ..Whether the formation of novel genes through alternative splicing has played a wider role in the evolution of the TRIM family remains to be investigated...
  18. pmc Two distinct variants of simian foamy virus in naturally infected mandrills (Mandrillus sphinx) and cross-species transmission to humans
    Augustin Mouinga-Ondeme
    Unité de Rétrovirologie, Centre International de Recherches Medicales de Franceville, Franceville, Gabon
    Retrovirology 7:105. 2010
    ..We evaluated the natural history of the virus in a free-ranging colony of mandrills and investigated possible transmission of mandrill SFV to humans...
  19. ncbi Host range studies of GB virus-B hepatitis agent, the closest relative of hepatitis C virus, in New World monkeys and chimpanzees
    J Bukh
    Hepatitis Viruses Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 0740, USA
    J Med Virol 65:694-7. 2001
    ..Finally, we failed to detect GBV-B in acute-phase serum from surgeon GB. Our data suggest that GBV-B is not a human virus and that GBV-B, like GBV-A, is a virus of New World monkeys...
  20. pmc Genetic stability of foamy viruses: long-term study in an African green monkey population
    M Schweizer
    Abteilung Virologie, Institut fur Medizinische Mikrobiologie und Hygiene, University of Freiburg, Freiburg, Germany
    J Virol 73:9256-65. 1999
    ..5 to 100%), and only a minimal genetic drift was recognized within the series of isolates. In conclusion, the low in vivo divergency of FV SU suggests that genetic variability is not important for the maintenance of FV persistence...
  21. pmc Primate-to-human retroviral transmission in Asia
    Lisa Jones-Engel
    University of Washington National Primate Research Center, Seattle, Washington 98195, USA
    Emerg Infect Dis 11:1028-35. 2005
    ..This study raises concerns that persons who work at or live around monkey temples are at risk for infection with SFV...
  22. ncbi Diagnosis of tuberculosis in macaques, using whole-blood in vitro interferon-gamma (PRIMAGAM) testing
    Manuel A Garcia
    Stanford University School of Medicine, Department of Comparative Medicine, RAF 1, Quad 7, Bldg 330, Stanford, California 94305 5410, USA
    Comp Med 54:86-92. 2004
    ..Fortunately, they were different animals; therefore, we recommend the parallel use of the TST and PRIMAGAM test for maximal overall sensitivity in a tuberculosis screening program, especially for cynomolgus macaques...
  23. ncbi Phylogenetic analysis of SIV and STLV type I in mandrills (Mandrillus sphinx): indications that intracolony transmissions are predominantly the result of male-to-male aggressive contacts
    E Nerrienet
    , Gabon
    AIDS Res Hum Retroviruses 14:785-96. 1998
    ....
  24. ncbi Considering human-primate transmission of measles virus through the prism of risk analysis
    Lisa Jones-Engel
    Washington National Primate Research Center, University of Washington, Seattle, Washington 98195, USA
    Am J Primatol 68:868-79. 2006
    ..Here the contrasting seroprevalences of the two sites are analyzed using risk analysis. These case studies show how risk analysis can be used to approach the phenomenon of cross-species pathogen transmission...
  25. ncbi Antigen recognition by serum antibodies in non-human primates experimentally infected with Mycobacterium tuberculosis
    Pier Natale Brusasca
    Public Health Research Institute, 225 Warren Street, Newark, New Jersy 07103, USA
    Comp Med 53:165-72. 2003
    ..These results provide experimental evidence of the potential value of ESAT-6 as an antigen for use in serodiagnosis of tuberculosis in non-human primates...
  26. pmc Spontaneous pathology of the common marmoset (Callithrix jacchus) and tamarins (Saguinus oedipus, Saguinus mystax)
    John M David
    College of Veterinary Medicine, Western University of Health Science, Pomona, CA, USA
    J Med Primatol 38:347-59. 2009
    ..Marmosets and tamarins are increasingly used in research, but their pathology remains poorly defined compared with Old World primates...
  27. ncbi Life on the edge: gastrointestinal parasites from the forest edge and interior primate groups
    Colin A Chapman
    Anthropology Department and McGill School of Environment, McGill University, Montreal, Canada
    Am J Primatol 68:397-409. 2006
    ....
  28. ncbi Outbreak of Mycobacterium bovis in a conditioned colony of rhesus (Macaca mulatta) and cynomolgus (Macaca fascicularis) macaques
    Manuel A Garcia
    Department of Comparative Medicine, Stanford University School of Medicine, Stanford, California 94305, USA
    Comp Med 54:578-84. 2004
    ....
  29. ncbi Idiopathic bilateral optic atrophy in the rhesus macaque
    Brad Fortune
    Discoveries in Sight, Devers Eye Institute, Legacy Health System, Portland, OR 97232, USA
    Invest Ophthalmol Vis Sci 46:3943-56. 2005
    ..To document the existence of idiopathic bilateral optic atrophy (BOA) in rhesus macaque monkeys and to characterize the structural and functional consequences of this condition...
  30. pmc Rabies in marmosets (Callithrix jacchus), Ceará, Brazil
    S R Favoretto
    , Brazil
    Emerg Infect Dis 7:1062-5. 2001
    ..The marmoset, Callithrix jacchus acchus, was determined to be the source of exposure...
  31. ncbi Exposure of hooded capuchin monkeys (Cebus apella cay) to a rabid bat at a zoological park
    D E Kenny
    Animal Health Department, Denver Zoological Gardens, Denver, Colorado 80205-4899, USA
    J Zoo Wildl Med 32:123-6. 2001
    ..Although a serologic titer of 0.05 IU/ml indicates an adequate human response after rabies vaccination, no similar information is available for nonhuman primates. To date, none of the monkeys has succumbed to rabies...
  32. ncbi Inactivated suckling mouse brain rabies vaccine provides short-term immunity in capuchin monkeys (Cebus apella)
    E C Passos
    Instituto Pasteur, Av. Paulista, 393, , SP, Brazil 01311-000
    J Zoo Wildl Med 32:55-7. 2001
    ..5 IU/ml after vaccination, but the immune response persisted for only 122.3 +/- 32.6 days. The SMBV was able to induce immune response in the capuchin monkeys, but protection was short-lived...
  33. ncbi Natural simian foamy virus infection in wild-caught gorillas, mandrills and drills from Cameroon and Gabon
    Sara Calattini
    Unité d Epidémiologie et Physiopathologie des Virus Oncogènes, Département EMMI, Institut Pasteur, Paris, France
    J Gen Virol 85:3313-7. 2004
    ....
  34. pmc B-virus from pet macaque monkeys: an emerging threat in the United States?
    S R Ostrowski
    Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Emerg Infect Dis 4:117-21. 1998
    ..A common observation was that children were more than three times as likely to be bitten than adults. The virus must be assumed to be a potential health hazard in macaque bite wounds; this risk makes macaques unsuitable as pets...
  35. ncbi Detection of Mycobacterium tuberculosis infection in chacma baboons (Papio ursinus) using the QuantiFERON-TB gold (in-tube) assay
    Sven D C Parsons
    DST NRF Centre of Excellence for Biomedical TB Research MRC Centre for Molecular and Cellular Biology Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Health Sciences, Stellenbosch University, Cape Town, South Africa
    J Med Primatol 38:411-7. 2009
    ..Early diagnosis of simian tuberculosis (TB) is vital to prevent transmission of this disease. We evaluated the ability of the QuantiFERON-TB Gold (In-Tube Method) assay (QFG-IT) to detect TB in chacma baboons (Papio ursinus)...
  36. pmc Splenic angioleiomyoma in an owl monkey (Aotus nancymae)
    Alfonso S Gozalo
    Comparative Medicine Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Med Primatol 39:385-8. 2010
    ..An adult male owl monkey (Aotus nancymae) underwent a splenectomy. When the spleen was removed, a small, nodular mass slightly bulging over the splenic surface was noted...
  37. pmc A small nonhuman primate model for filovirus-induced disease
    Ricardo Carrion
    Department of Virology and Immunology, Texas Biomedical Research Institute, 7620 NW Loop 410, San Antonio, TX 78227, USA
    Virology 420:117-24. 2011
    ..Lymphoid necrosis and lymphocytic depletion observed in spleen. These findings provide support for the use of the common marmoset as a small nonhuman primate model for filovirus induced hemorrhagic fever...
  38. pmc Naturally acquired human Plasmodium knowlesi infection, Singapore
    Oon Tek Ng
    Department of Infectious Disease, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, Singapore 308433
    Emerg Infect Dis 14:814-6. 2008
    ..In industrialized countries, free-ranging primates are a potential source of P. knowlesi human infection. P. knowlesi infection is a differential diagnosis of febrile illness acquired in Singapore...
  39. pmc Bionomics of Anopheles latens in Kapit, Sarawak, Malaysian Borneo in relation to the transmission of zoonotic simian malaria parasite Plasmodium knowlesi
    Cheong H Tan
    Infectious Diseases Research Centre, Institute for Medical Research Jalan Pahang, 50588 Kuala Lumpur, Malaysia
    Malar J 7:52. 2008
    ..A study was initiated to identify the vectors of malaria, to elucidate where transmission is taking place and to understand the bionomics of the vectors in Kapit...
  40. ncbi Seroepidemiologic, molecular, and phylogenetic analyses of simian T-cell leukemia viruses (STLV-I) from various naturally infected monkey species from central and western Africa
    N K Saksena
    Department of Medicine, SUNY Health Science Center, Syracuse 13210
    Virology 198:297-310. 1994
    ..Comparative amino acid analyses indicated that there was marked conservation of the TAX protein regardless of host species, while the pol and REX proteins exhibited increasing levels of diversity...
  41. ncbi Ebola (subtype Reston) virus among quarantined nonhuman primates recently imported from the Philippines to the United States
    P E Rollin
    Special Pathogens Branch and Molecular Pathology and Ultrastructure Activity, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Infect Dis 179:S108-14. 1999
    ....
  42. ncbi Risk assessment: A model for predicting cross-species transmission of simian foamy virus from macaques (M. fascicularis) to humans at a monkey temple in Bali, Indonesia
    Gregory Engel
    National Primate Research Center, University of Washington, Seattle, Washington 98195, USA
    Am J Primatol 68:934-48. 2006
    ..This model sets the stage for a discussion about modeling as a risk assessment tool and the kinds of data that are required to accurately predict transmission...
  43. pmc Immunoglobulin G enzyme-linked immunosorbent assay using truncated nucleoproteins of Reston Ebola virus
    T Ikegami
    Special Pathogens Laboratory, Department of Virology 1, National Institute of Infectious Diseases, 4 7 1 Gakuen, Musashimurayama, Tokyo 208 0011, Japan
    Epidemiol Infect 130:533-9. 2003
    ..The results indicate that this IgG ELISA is useful for detecting EBO-R specific antibody, and may have a potential to discriminate EBO-R infection from other subtypes...
  44. ncbi Histopathology of natural Ebola virus subtype Reston infection in cynomolgus macaques during the Philippine outbreak in 1996
    Tetsuro Ikegami
    Special Pathogens Laboratory, Department of Virology 1, National Institute of Infectious Diseases, 4 7 1 Gakuen, Musashimurayama, Tokyo 208 0011, Japan
    Exp Anim 51:447-55. 2002
    ..These results indicate that EBO-R infection is characterized by systemic coagulopathy and an increase in blood-derived macrophages/monocytes in accordance with the EBO-R propagation in macrophages/monocytes...
  45. ncbi Intestinal stromal tumors in a simian immunodeficiency virus-infected, simian retrovirus-2 negative rhesus macaque (Macaca mulatta)
    H Bielefeldt-Ohmann
    Washington National Primate Research Center, University of Washington, Box 357331, Seattle, WA 98195, USA
    Vet Pathol 42:391-6. 2005
    ..Collectively, these findings suggest a relation to but not absolute identity with simian mesenchymoproliferative disorders (MPD) or typical gastrointestinal stromal tumors (GISTs)...
  46. ncbi Development of an immunofluorescence method for the detection of antibodies to Ebola virus subtype Reston by the use of recombinant nucleoprotein-expressing HeLa cells
    Tetsuro Ikegami
    Department of Virology 1, National Institute of Infectious Diseases, Musashimurayama, Tokyo, Japan
    Microbiol Immunol 46:633-8. 2002
    ..These results suggest that this new IFA is useful for seroepidemiological studies of EBO-R infection among monkeys...
  47. pmc Identification of rhesus macaque genital microbiota by 16S pyrosequencing shows similarities to human bacterial vaginosis: implications for use as an animal model for HIV vaginal infection
    Gregory T Spear
    Department of Immunology Microbiology, Rush University Medical Center, Chicago, IL 60612, USA
    AIDS Res Hum Retroviruses 26:193-200. 2010
    ..These results also suggest macaques could be used as an animal model to study some aspects of bacterial vaginosis...
  48. ncbi Immunogenicity of a DNA vaccine against herpes B virus in mice and rhesus macaques
    J E Loomis-Huff
    Center for Comparative Medicine, School of Medicine, University of California-Davis, 95616, USA
    Vaccine 19:4865-73. 2001
    ..These results demonstrated that DNA immunization can be used to generate an immune response against a B virus glycoprotein in uninfected macaques...
  49. pmc Classic AIDS in a sooty mangabey after an 18-year natural infection
    Binhua Ling
    Tulane National Primate Research Center, 18703 Three Rivers Rd, Covington, LA 70433, USA
    J Virol 78:8902-8. 2004
    ..Therefore, the results also suggest that SMs have a special mechanism for resisting AIDS development...
  50. pmc B-virus (Cercopithecine herpesvirus 1) infection in humans and macaques: potential for zoonotic disease
    Jennifer L Huff
    Department of Medical Microbiology and Immunology, University of California, Davis, California 95616, USA
    Emerg Infect Dis 9:246-50. 2003
    ..Knowledge of the clinical signs and risk factors for human B-virus disease allows early initiation of antiviral therapy and prevents severe disease or death...
  51. ncbi Anopheles dirus co-infection with human and monkey malaria parasites in Vietnam
    Shusuke Nakazawa
    Department of Protozoology, Institute of Tropical Medicine and the Global Center of Excellence Program, Nagasaki University, Japan
    Int J Parasitol 39:1533-7. 2009
    ..This study also shows that the preservation of mosquito salivary glands on filter paper, and the down-stream extraction of parasite DNA and RNA from those, offers a powerful resource for molecular epidemiological studies on malaria...
  52. ncbi Serological detection of adenoviruses in non-human primates maintained in a colony in Kenya
    J M Mwenda
    Institute of Primate Research, P O Box 24481 00502, Karen, Nairobi, Kenya
    East Afr Med J 82:371-5. 2005
    ..To date, limited studies have been done to determine the prevalence of adenovirus infection in non-human primates with the goal of developing a non-human primate model that can be used to study the mechanisms of infection...
  53. ncbi Kuru experiments triggered the emergence of pathogenic SIVmac
    Cristian Apetrei
    Division of Microbiology, Tulane National Primate Research Center, Covington, Louisiana 70433, USA
    AIDS 20:317-21. 2006
  54. ncbi High simian T-cell leukemia virus type 1 proviral loads combined with genetic stability as a result of cell-associated provirus replication in naturally infected, asymptomatic monkeys
    Anne Sophie Gabet
    Unité d Oncogenèse Virale, Centre Leon Berard, Lyon, France
    Int J Cancer 107:74-83. 2003
    ....
  55. ncbi Antibody responses to rhesus cytomegalovirus glycoprotein B in naturally infected rhesus macaques
    Yujuan Yue
    Center for Comparative Medicine, University of California, Davis, County Road 98 and Hutchison Drive, Davis, CA 95616, USA
    J Gen Virol 84:3371-9. 2003
    ..Thus, the rhesus macaque model of HCMV infection is relevant for testing gB-based immune therapies...
  56. ncbi Multiplex analysis of cytokines in the blood of cynomolgus macaques naturally infected with Ebola virus (Reston serotype)
    K L Hutchinson
    Special Pathogens Branch, Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road NE, Mail stop G14, Atlanta, GA 30333, USA
    J Med Virol 65:561-6. 2001
    ..High levels of MCP-1 and MIP-1beta, and RANTES were found in infected primates and, while levels were more variable, IL-1beta was detected only in infected animals...
  57. ncbi The putative haemobartonella that influences Plasmodium falciparum parasitaemia in squirrel monkeys is a haemotrophic mycoplasma
    Harold Neimark
    Department of Microbiology and Immunology, Morse Institute for Molecular Biology, Campus Box 44, College of Medicine, State University of New York, Brooklyn, NY 11203, USA
    Microbes Infect 4:693-8. 2002
    ..Haemotrophic mycoplasmas are a newly identified group of mycoplasmas that parasitise the surfaces of erythrocytes of a wide variety of vertebrate hosts...
  58. ncbi Surgical technique for ambulatory management of airsacculitis in a chimpanzee (Pan troglodytes)
    L R Hill
    Department of Veterinary Sciences, The University of Texas M. D. Anderson Cancer Center, Bastrop, Texas 78602, USA
    Comp Med 51:80-4. 2001
    ..This method allowed treatment without interfering with social standing or subjection to repeated anesthetic and treatment episodes. This method could be a simple, useful alternative for managing airsacculitis in nonhuman primates...
  59. ncbi Molecular detection of novel adenoviruses in fecal specimens of captive monkeys with diarrhea in China
    K Banyai
    Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Vet Microbiol 142:416-9. 2010
    ..A better understanding of the epidemiology of SAdVs and their potential role in gastroenteritis is critical to the implementation of advanced prevention strategies against AdV infection in captive primates...
  60. ncbi Comparison of tamarins and marmosets as hosts for GBV-B infections and the effect of immunosuppression on duration of viremia
    Robert E Lanford
    Department of Virology and Immunology, Southwest National Primate Research Center, and Southwest Foundation for Biomedical Research, San Antonio, TX 78227, USA
    Virology 311:72-80. 2003
    ..The greater availability of marmosets in comparison to tamarins will greatly facilitate future research efforts with this model...
  61. ncbi Immunity against the GBV-B hepatitis virus in tamarins can prevent productive infection following rechallenge and is long-lived
    Jens Bukh
    Hepatitis Viruses Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 8009, USA
    J Med Virol 80:87-94. 2008
    ..We also demonstrated that the immunity was long-lived: 1 year after the fourth challenge, the animal with sterilizing immunity had low titer viremia for only 1 week following an additional challenge...
  62. ncbi Isolation of cytomegalovirus and foamy virus from the drill monkey (Mandrillus leucophaeus) and prevalence of antibodies to these viruses amongst wild-born and captive-bred individuals
    E L Blewett
    Department of Biochemistry and Microbiology, College of Osteopathic Medicine, Oklahoma State University, Tulsa, Oklahoma 74107, U S A
    Arch Virol 148:423-33. 2003
    ..ELISA testing of sera from wild-born and captive-bred drills indicated that the prevalence of antibodies reactive with these two viruses was 93.2% for DrCMV and 20.3% for SFV-drl...
  63. ncbi Human culture and monkey behavior: Assessing the contexts of potential pathogen transmission between macaques and humans
    Agustin Fuentes
    Department of Anthropology, University of Notre Dame, Notre Dame, Indiana 46556, USA
    Am J Primatol 68:880-96. 2006
    ..These similarities and differences are interpreted as resulting from differences in macaque species and behaviors, and human demography, culture, and behavioral patterns...
  64. pmc Infectious agent and immune response characteristics of chronic enterocolitis in captive rhesus macaques
    Karol Sestak
    Division of Microbiology and Immunolgy, Tulane National Primate Research Center, Covington, Louisiana 70433, USA
    Infect Immun 71:4079-86. 2003
    ..The data also suggest that chronic colitis in rhesus macaques may have potential as a model of inflammatory bowel disease in humans...
  65. ncbi Prevalence of enzootic simian viruses among urban performance monkeys in Indonesia
    Michael A Schillaci
    Department of Social Sciences, University of Toronto at Scarborough, Toronto, Ontario, Canada
    Trop Med Int Health 10:1305-14. 2005
    ..No evidence of infection with simian immunodeficiency virus was detected in these macaques. These results suggest that urban performance monkeys are a reservoir for enzootic simian viruses known to be capable of infecting humans...
  66. pmc Temple monkeys and health implications of commensalism, Kathmandu, Nepal
    Lisa Jones-Engel
    University of Washington National Primate Research Center, Seattle, Washington 98195, USA
    Emerg Infect Dis 12:900-6. 2006
    ..Humans who come into contact with macaques at Swoyambhu risk exposure to enzootic primateborne viruses. We discuss implications for public health and primate management strategies that would reduce contact between humans and primates...
  67. ncbi Identification of multiple simian immunodeficiency virus (SIV)-specific CTL epitopes in sooty mangabeys with natural and experimentally acquired SIV infection
    A Kaur
    Division of Immunology, New England Regional Primate Research Center, Harvard Medical School, Southborough, MA 01772, USA
    J Immunol 164:934-43. 2000
    ..Longitudinal studies of viral load and sequence variation in CTL epitopes may provide useful information on the role of CTL in control or persistence of SIV infection in sooty mangabeys...
  68. pmc Novel TRIM5 isoforms expressed by Macaca nemestrina
    Greg Brennan
    Department of Microbiology, University of Washington, Seattle, WA 98121, USA
    J Virol 81:12210-7. 2007
    ..The expression of TRIM5 alleles incapable of restricting HIV-1 infection may contribute to the previously reported increased susceptibility of M. nemestrina to HIV-1 infection in vivo...
  69. ncbi Genomic evolution, patterns of global dissemination, and interspecies transmission of human and simian T-cell leukemia/lymphotropic viruses
    J P Slattery
    Laboratory of Genomic Diversity, National Cancer Institute Frederick Research Development Center Frederick, Maryland 21702 USA
    Genome Res 9:525-40. 1999
    ..Together, these patterns generate a model of HTLV/STLV emergence marked by an ancient ancestry, differential rates of divergence, and continued global expansion...
  70. pmc Simian T-cell lymphotropic virus type 1 from Mandrillus sphinx as a simian counterpart of human T-cell lymphotropic virus type 1 subtype D
    R Mahieux
    , Institut Pasteur, 75724 Paris Cedex 15, France
    J Virol 72:10316-22. 1998
    ..Due to the quasi-identity of both human and monkey viruses, interspecies transmission episodes leading to such a clade may have occurred recently...
  71. ncbi Molecular epidemiology of simian T-lymphotropic virus (STLV) in wild-caught monkeys and apes from Cameroon: a new STLV-1, related to human T-lymphotropic virus subtype F, in a Cercocebus agilis
    E Nerrienet
    Centre Pasteur du Cameroun, BP 1274, , Cameroon
    J Gen Virol 82:2973-7. 2001
    ....
  72. ncbi Identification and molecular characterization of new STLV-1 and STLV-3 strains in wild-caught nonhuman primates in Cameroon
    Florian Liegeois
    UMR 145, Institut de Recherche pour le Developpement IRD and University of Montpellier 1, Montpellier, France
    Virology 371:405-17. 2008
    ..cephus. Finally, we identify relative divergence levels in the tax/rex phylogeny suggesting that additional types of PTLV should be defined, particularly for the highly divergent STLV-1(MarB43) strain that we provisionally name STLV-5...
  73. ncbi Two distinct STLV-1 subtypes infecting Mandrillus sphinx follow the geographic distribution of their hosts
    M Makuwa
    Laboratoire de Virologie, UGENET, CDP, SEGC Lopé, Centre International de Recherches Medicales, Franceville, Gabon
    AIDS Res Hum Retroviruses 20:1137-43. 2004
    ..The clustering of these new STLV-1mnd sequences with HTLV-1 subtype D and F suggests first, past simian-to-human transmissions in Central Africa and second, that species barriers are easier to cross over than geographic barriers...
  74. ncbi A novel, divergent simian T-cell lymphotropic virus type 3 in a wild-caught red-capped mangabey (Cercocebus torquatus torquatus) from Nigeria
    L Meertens
    , , Batiment Lwoff, Institut Pasteur, 25 28 Rue du Dr Roux, 75724 Paris Cedex 15, France
    J Gen Virol 84:2723-7. 2003
    ....
  75. doi A novel fusion gene, TRIM5-Cyclophilin A in the pig-tailed macaque determines its susceptibility to HIV-1 infection
    Cheng Hong Liao
    Kunming Primate Research Center, Chinese Academy of Sciences, Kunming, Yunnan, China
    AIDS 21:S19-26. 2007
    ..However, the pig-tailed macaque (Macaca nemestrina) is an exception and is susceptible to HIV-1 infection. This study dissects the molecular mechanism of the pig-tailed macaque's susceptibility to HIV-1 infection...
  76. pmc Simian T-cell leukemia virus (STLV) infection in wild primate populations in Cameroon: evidence for dual STLV type 1 and type 3 infection in agile mangabeys (Cercocebus agilis)
    Valerie Courgnaud
    UR36, IRD, and University of Montpellier I, Montpellier, France
    J Virol 78:4700-9. 2004
    ....
  77. pmc Gastrointestinal disease in simian immunodeficiency virus-infected rhesus macaques is characterized by proinflammatory dysregulation of the interleukin-6-Janus kinase/signal transducer and activator of transcription3 pathway
    Mahesh Mohan
    Division of Comparative Pathology, Tulane National Primate Research Center, 18703 Three Rivers Rd, Covington, LA 70433, USA
    Am J Pathol 171:1952-65. 2007
    ..Despite high SOCS-3 expression, STAT3 remained constitutively active, providing a possible explanation for persistent intestinal inflammation and immune activation that may favor viral replication and disease pro-gression...
  78. pmc Unique pattern of enzootic primate viruses in Gibraltar macaques
    Gregory A Engel
    University of Washington National Primate Research Center, Seattle, Washington, USA
    Emerg Infect Dis 14:1112-5. 2008
    ..All macaques were seronegative for herpesvirus B, simian T-cell lymphotropic virus, simian retrovirus, simian immunodeficiency virus, and rhesus cytomegalovirus. Seroprevalence of simian foamy virus reached 88% among adult animals...
  79. ncbi Malaria and Hepatocystis species in wild macaques, southern Thailand
    Sunee Seethamchai
    Department of Biology, Faculty of Science, Naresuan University, Pitsanulok Province, Thailand
    Am J Trop Med Hyg 78:646-53. 2008
    ..These findings indicate regional differences in malaria distribution among these macaques, as well as differences in potential risk of disease transmission to humans...
  80. pmc Viruses from nonhuman primates
    Regis A Vilchez
    Emerg Infect Dis 12:1802-3; author reply 1803. 2006
  81. ncbi Reactivation of a Trypanosoma cruzi infection in a rhesus monkey (Macaca mulatta) experimentally infected with SIV
    E Kunz
    Department of Primate Veterinary Medicine and Primate Husbandry, German Primate Center, 37077 Gottingen, Germany
    Vet Pathol 39:721-5. 2002
    ..The animal developed no specific clinical symptoms of American trypanosomiasis, but histologically a chagasic myocarditis was detected. Analysis of the small subunit rRNA gene of the trypanosome identified the protozoan as T. cruzi...
  82. ncbi The role of the armadillo and sooty mangabey monkey in human leprosy
    Heather K Hamilton
    Department of Dermatology and Baylor Clinic, Baylor College of Medicine, Houston, Texas, USA
    Int J Dermatol 47:545-50. 2008
    ..Recently, molecular methods have been developed for leprosy and may help resolve the role of zoonoses in leprosy...
  83. pmc Th-1-type cytotoxic CD8+ T-lymphocyte responses to simian immunodeficiency virus (SIV) are a consistent feature of natural SIV infection in sooty mangabeys
    Zichun Wang
    Division of Immunology, New England Primate Research Center, Harvard Medical School, One Pine Hill Dr, Southborough, Massachusetts 01772, USA
    J Virol 80:2771-83. 2006
    ....
  84. ncbi Coat condition, housing condition and measurement of faecal cortisol metabolites--a non-invasive study about alopecia in captive rhesus macaques (Macaca mulatta)
    Hanspeter W Steinmetz
    Division of Zoo Animals and Exotic Pets, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland
    J Med Primatol 35:3-11. 2006
    ..Previous studies have characterized alopecia in captive rhesus macaques (Macaca mulatta) by a mixed partial to complete alopecia in a bilateral symmetric pattern...
  85. ncbi Central memory CD4 T cells are the predominant cell subset resistant to anergy in SIV disease resistant sooty mangabeys
    Pavel Bostik
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    AIDS 20:181-8. 2006
    ....
  86. ncbi A case report: Entamoeba histolytica infections in the rhesus macaque, China
    Bo Jiang
    Department of Parasitology, College of Veterinary Medicine, Sichuan Agricultural University, Ya an 625014, China
    Parasitol Res 103:915-7. 2008
    ..The early diagnosis of an E. histolytica infection allowed a proper antiamoebic treatment in an early stage of infection resulting in a successful outcome after therapy...
  87. ncbi Diagnostic exercise: papulovesicular dermatitis in rhesus macaques (Macaca mulatta)
    T R Schoeb
    Department of Genetics, Univeresity of Alabama at Birmingham, Birmingham, AL 35294, USA
    Vet Pathol 45:592-4. 2008
    ..Simian varicella virus was identified as the cause by polymerase chain reaction analysis and serologic testing...
  88. ncbi Comparison of efficacy of moxidectin and ivermectin in the treatment of Strongyloides fulleborni infection in rhesus macaques
    Jason P Dufour
    Division of Veterinary Medicine, Tulane National Primate Research Center, Covington, LA 70433, USA
    J Med Primatol 35:172-6. 2006
    ..There is presently a Strongyloides fulleborni infection rate of approximately 27% in the Tulane National Primate Research Center's breeding colonies despite the routine therapeutic and prophylactic use of ivermectin...
  89. ncbi Immunological concepts in tuberculosis diagnostics for non-human primates: a review
    Philana Ling Lin
    Department of Pediatrics, Children s Hospital of Pittsburgh, 3705 Fifth Avenue, Pittsburgh, PA 15213, USA
    J Med Primatol 37:44-51. 2008
    ..Lastly, the risk and benefits to the primate colony, staff and resources must be carefully weighed when deciding to euthanize monkeys to make the diagnosis of tuberculosis...
  90. pmc Disseminated simian varicella virus infection in an irradiated rhesus macaque (Macaca mulatta)
    Krishnan Kolappaswamy
    Program of Comparative Medicine, Department of Pathology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Virol 81:411-5. 2007
    ..These findings parallel those from humans with disseminated varicella infection and support the usefulness of SVV infection as a model for human varicella-zoster virus infection, particularly virus reactivation after gamma-irradiation...
  91. pmc Early resolution of acute immune activation and induction of PD-1 in SIV-infected sooty mangabeys distinguishes nonpathogenic from pathogenic infection in rhesus macaques
    Jacob D Estes
    Department of Microbiology, Medical School, School of Public Health, University of Minnesota, Minneapolis, MN 55455, USA
    J Immunol 180:6798-807. 2008
    ..These findings point to early control of immune activation by host immunoregulatory mechanisms as a major determinant of the different disease outcomes in SIV infection of natural vs non-natural hosts...
  92. ncbi Dermatologic investigation of alopecia in rhesus macaques (Macaca mulatta)
    Hanspeter W Steinmetz
    Division of Zoo Animals and Exotic Pets, University of Zurich, Winterthurerstrasse 260, 8057 Zurich, Switzerland
    J Zoo Wildl Med 36:229-38. 2005
    ..Future studies should try to identify disturbances in extrinsic or intrinsic factors influencing hair follicle activity in rhesus macaques...
  93. ncbi CD4+ T cells from simian immunodeficiency virus disease-resistant sooty mangabeys produce more IL-2 than cells from disease-susceptible species: involvement of p300 and CREB at the proximal IL-2 promoter in IL-2 up-regulation
    Pavel Bostik
    Department of Pathology and Laboratory Medicine, Emory University, 101 Woodruff Circle, Atlanta, GA 30322, USA
    J Immunol 178:7720-9. 2007
    ..These unique characteristics of the proximal IL-2 promoter in SM therefore can represent one of the mechanisms contributing to the resistance of these cells to undergo anergy...
  94. ncbi Corynebacterial necrohemorrhagic cystitis in two female macaques
    Edward L Stevens
    Pathology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, USA
    J Am Assoc Lab Anim Sci 46:65-9. 2007
    ..Corynebacterial necrohemorrhagic cystitis therefore was determined to be the cause of death in both animals. To our knowledge, this is the fi rst report of corynebacterial cystitis in nonhuman primates...
  95. ncbi [Observation on Rhesus monkeys infected second time with H5N1 avian influenza virus]
    Wei bo Zhao
    Guangdong Laboratory Animal Monitoring Institute, Guangzhou 510260, China
    Bing Du Xue Bao 23:282-6. 2007
    ....
  96. ncbi Amyloidosis in macaques in adler primatological center
    E S Naumenko
    Institute of Medical Primatology, Russian Academy of Medical Sciences, Sochi Adler
    Bull Exp Biol Med 136:80-3. 2003
    ..8%) was hepatic amyloidosis. Simian and human amyloidosis are compared. Amyloidosis in macaques can be used as the model process for studies of amyloidosis in humans...
  97. ncbi Detection of Cyclospora cayetanensis in animal fecal isolates from Nepal using an FTA filter-base polymerase chain reaction method
    Dan My T Chu
    Division of Microbiological Studies, and Division of Virulence Assessment, Center for Food Safety and Applied Nutrition, Food and Drug Administration, College Park, MD 20704, USA
    Am J Trop Med Hyg 71:373-9. 2004
    ..cayetanensis in the dog and monkey samples. However, in the absence of tissue analysis, the assignment of these animals as a natural reservoir host for C. cayetanensis remains to be determined...
  98. ncbi Rhesus rhadinovirus infection in healthy and SIV-infected macaques at Tulane National Primate Research Center
    K Ruff
    Department of Microbiology and Immunology, Program in Molecular Pathogenesis and Immunity, Tulane Cancer Center, Tulane University Health Sciences Center, New Orleans, LA 70112, USA
    J Med Primatol 32:1-6. 2003
    ..The results indicate that RRV infection in PBMC is not predictive of, and is apparently not required for, development of lymphoma or hyperplastic lymphadenopathy in SIV-infected animals at TNPRC...
  99. ncbi Herpes B-virus seroreactivity in a colony of Macaca mulatta: data from the Sabana Seca Field Station, a new specific pathogen-free program
    Carlos A Sariol
    Caribbean Primate Research Center, Unit of Comparative Medicine, University of Puerto Rico Medical Sciences Campus, San Juan, PR 00936, USA
    J Med Primatol 34:13-9. 2005
    ..6% of animals recruited to this SPF program showed serovariability to B-virus over the initial 2 years of examination. Implications for all SPF programs are discussed in this article...
  100. ncbi Prevalence of antibodies to selected viruses in a long-term closed breeding colony of rhesus macaques (Macaca mulatta) in Brazil
    Marcia Ribeiro Andrade
    Oswaldo Cruz Foundation, Centro de Criação de Animais de Loboratório, Rio de Janeiro, Brazil
    Am J Primatol 59:123-8. 2003
    ..All samples were negative for antibodies against the simian retroviruses. The overall prevalence of antibodies was 95% for RhCMV, 45% for B virus, 35% for HAV, and 1% for MV. Prevalence was found to vary by age group...
  101. ncbi Trichomonad gastritis in rhesus macaques (Macaca mulatta) infected with simian immunodeficiency virus
    I Kondova
    Division of Comparative Pathology, New England Primate Research Center, Harvard Medical School, Southborough, MA 01772 9102, USA
    Vet Pathol 42:19-29. 2005
    ..On the basis of these observations, we conclude that Tritrichomonas can be a significant cofactor in the development of necrosuppurative gastritis in SIV-infected rhesus macaques...

Research Grants42

  1. Primate enteroviruses transmission in Bangladesh
    Lisa Jones Engel; Fiscal Year: 2007
    ..Ultimately, this data will provide insight into the potential emergence of NHP-borne pathogens and help to deter the spread of emerging zoonotic threats. [unreadable] [unreadable]..
  2. Caloric Restriction and Aging in Eyes
    Peter Gouras; Fiscal Year: 2010
    ..Because many of these primates are near the end of their lifespan, there is an element of urgency in our goal to correlate noninvasive clinical testing prior with post mortem histology. ..
  3. Viral Etiology of Kaposi's sarcoma-like Tumors
    TIMOTHY ROSE; Fiscal Year: 2005
    ..Additional training and focused research in virology would allow Dr. Rose to expand upon his initial discovery and make further significant contributions in the fields of herpesviruses and viral pathogenicity. ..
  4. A macaque model for AIDS-related oral malignancies
    TIMOTHY ROSE; Fiscal Year: 2007
    ..Such a model could directly impact the prevention, diagnosis, and treatment of this devastating human disease. [unreadable] [unreadable]..
  5. Resolution of Acute Hepatitis B Virus Infections in Chimpanzees
    Robert Lanford; Fiscal Year: 2008
    ..Our long-term objective is to apply our understanding of the resolution of acute HBV infection to the development of effective new immunotherapies for chronic HBV infections. [unreadable] [unreadable] [unreadable]..
  6. GBV-B: A SMALL PRIMATE MODEL FOR HEPATITIS C INFECTION
    Robert Lanford; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  7. Gene Expression Analyses During IFN Antiviral Therapy
    Robert Lanford; Fiscal Year: 2005
    ..These data will help determine why interferon therapy is often unsuccessful for chronic HCV infections and provide cellular targets for future therapies. ..
  8. A New DNA Vaccine Against HIV Disease in Macaques
    Edward Stephens; Fiscal Year: 2008
    ..Vaccine boosts will continue after drug therapy had been withdrawn. These studies will be applicable to HIV infected persons under HAART. ..
  9. Replication and Persistence of Primate Lentiviruses
    Welkin Johnson; Fiscal Year: 2009
    ....
  10. Social and psychological risk for infectious illness
    Sheldon A Cohen; Fiscal Year: 2010
    ..abstract_text> ..
  11. Role of Targeted Mutations in ViF on SHIV Pathogenesis
    Edward Stephens; Fiscal Year: 2006
    ..The proposed studies will provide new information on the role of this Vif motif in pathogenesis using a relevant macaque model. ..
  12. INTERACTIONS BETWEEN CMV AND SIV IN RHESUS MACAQUES
    Amitinder Kaur; Fiscal Year: 2007
    ..Specific Aim #3: To examine mechanisms of restoration of CMV-specific immunity in SIV-infected macaques treated with HAART. ..
  13. Modular Chimeric Vaccines tailored for malaria parasites
    Alberto Moreno; Fiscal Year: 2010
    ..The emergence of P. vivax chloroquine and primaquine drug resistant strains has brought increased emphasis to the need for alternative prophylactic and therapeutic strategies to control this infection. ..
  14. THE PROTEIN C RECEPTOR AND WEGENER'S VASCULOPATHY
    Shinichiro Kurosawa; Fiscal Year: 2003
    ..In addition, the results will provide a foundation for future studies investigating potential therapeutic targets that modulate neutrophil-mediated endothelial injury, particularly for cANCA-mediated vasculitis. ..
  15. SHIV ASSOCIATED ENCEPHALOPATHY
    Edward Stephens; Fiscal Year: 2003
    ..It is anticipated that the proposed studies will provide valuable information which will improve our understanding of HIV-1 neuropathogenesis. ..
  16. Calorie Restriction Effects on Chromosomal Aberrations
    CHARLEEN MOORE; Fiscal Year: 2003
    ..The results will be essential in identifying potential mechanisms by which CR acts in cancer prevention and delay of the aging process in long-lived species such as the rhesus monkey and humans. ..
  17. HCV-ALCOHOL INTERACTIONS-- PATHOGENESIS AND EPIDEMIOLOGY
    Jack Stapleton; Fiscal Year: 2001
    ..These studies may lead to insights on the mechanism of liver injury and help define those patients who are most likely to have progressive liver injury. ..
  18. Pathogen-Host Standoff: Persistent and Latent Infection
    Joanne Flynn; Fiscal Year: 2004
    ..This meeting seeks to bring together researchers from a variety of fields, with the common goal of understanding how persistent pathogens survive and how the host responds to such pathogens. ..
  19. Cell immune responses in SIV-infected sooty mangabeys
    Amitinder Kaur; Fiscal Year: 2004
    ..abstract_text> ..
  20. Effect of Alcohol on SHIV Neuroinvasion
    Edward Stephens; Fiscal Year: 2004
    ..The results of these studies should provide direct evidence on the effect of ethanol on primate lentivirus neuroinvasion and neuropathogenesis. ..
  21. Novel Linear Peptide Universal Malaria Vaccines
    Alberto Moreno; Fiscal Year: 2005
    ..falciparum, respectively. These approaches will provide strong data to evaluate the LPC approach as a ways forward for clinical trials, whether used singly or in combination with other malaria vaccine platforms. ..
  22. Maternal flu infection and brain development in primates
    Christopher L Coe; Fiscal Year: 2010
    ....
  23. A NON-HUMAN PRIMATE MODEL OF TUBERCULOSIS AND AIDS
    Joanne Flynn; Fiscal Year: 2004
    ..Once a non-human primate model for tuberculosis is established, it could be used to test vaccines, immunotherapy, and new treatment options for tuberculosis. ..
  24. Influence of SIV gp120 on Mycobacterial Pathogenesis
    ELIZABETH HENDRICKS; Fiscal Year: 2004
    ..To work with Drs. Mansfield, Desrosiers, and Bloom, who have extensive experience in the field of infectious disease, offers an exceptional opportunity to train with some of the foremost researchers in their field. ..
  25. Supporting Human ART Through Basic Science
    Barry Bavister; Fiscal Year: 2004
    ..This Symposium will attract members of the human ART community and scientists working in animal ART, and will provide a basis for continued and expanded interactions between these two groups. ..
  26. Transgenic mouse for modifying antiviral mAb specificity
    Welkin Johnson; Fiscal Year: 2006
    ..In the second case, the hypothesis to be tested is that native envelope complexes contain conformationally induced epitopes that are not present in the monomeric envelope protein. ..
  27. Animal models to design & evaluate improved VZV vaccines
    WAYNE GRAY; Fiscal Year: 2007
    ..The study may also provide support for use of the VZV vaccine as a recombinant vector for immunization against other infectious agents, particularly human immunodeficiency virus (HIV). ..
  28. CHEMOKINE RECEPTORS AND SIV NEUROPATHOGENESIS
    Susan Westmoreland; Fiscal Year: 2003
    ..We will then assess neuronal cultures for cellular injury and induction of apoptosis. ..
  29. Latent and Reactivation Tuberculosis
    Joanne Flynn; Fiscal Year: 2007
    ..These studies are the first to study reactivation in an immunologically tractable animal model that is similar to human latent tuberculosis. ..
  30. Molecular Mechanisms of Antigenic Variation in Malaria
    Mary R Galinski; Fiscal Year: 2010
    ....
  31. A BABOON MODEL FOR THE GENETICS OF CORTICAL BONE MATERIAL PROPERTIES
    LORENA HAVILL; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  32. COMPARATIVE MEDICAL SCIENTIST POSTDOCTORAL TRAINING
    Trenton Schoeb; Fiscal Year: 2006
    ..abstract_text> ..
  33. Mechanisms of HIV-Induced PNS Disease: The SIV Macaque Model
    Joseph Mankowski; Fiscal Year: 2009
    ..The goal of these comprehensive, integrated studies of HIV sensory neuropathy in our novel SIV primate model is to advance the understanding of HIV-SN pathogenesis to foster new therapeutic approaches. ..
  34. ANTI-HIV-1 ACTIVITY OF MANNAN-BINDING LECTIN
    Gregory Spear; Fiscal Year: 2003
    ..3. Utilize inhibitors of glycosylation to enhance biological effects of MBL. Exarnine the interaction of MBL with anti-viral antibodies in mediating anti-viral effects. Deterrnine the interaction of HIV-1 with MBL in vivo. ..
  35. PRIMATE MODEL AND PATHOGENESIS OF ANTHRAX SEPSIS
    Shinichiro Kurosawa; Fiscal Year: 2009
    ..anthracis, provide clinically-relevant animal models for future evaluation of new therapeutic approaches, and determine the role of APC and the protein C pathway in regulating anthrax-mediated pathogenesis. ..
  36. Viral Host Interactions in SIV Cardiac Dysfunction
    Joseph Mankowski; Fiscal Year: 2008
    ..These studies will set the stage for performing interventive studies in SIV-infected macaques using approaches to target specific MMPs to prevent cardiac dysfunction. [unreadable] [unreadable] [unreadable]..
  37. EMBRYO TECHNOLOGIES FOR PROPAGATION OF RHESUS MONKEYS
    Barry Bavister; Fiscal Year: 2006
    ..abstract_text> ..
  38. PLASMODIUM VIVAX MSP-3 AND MSP-9 AS VACCINE IMMUNOGENES
    Mary Galinski; Fiscal Year: 2007
    ..vivax vaccine candidates based on these antigens and also serve to establish reliable procedures to test and evaluate antigens in non-human primate models for safety, immunogenicity and efficacy. ..
  39. HIV 1 Gene Polymorphisms Associated with Non Progression
    Thomas Greenough; Fiscal Year: 2002
    ....