Genomes and Genes
Summary: Diseases of chimpanzees, gorillas, and orangutans.
Publications150 found, 100 shown here
- Origin of the human malaria parasite Plasmodium falciparum in gorillasWeimin Liu
Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
Nature 467:420-5. 2010..falciparum formed a monophyletic lineage within the gorilla parasite radiation. These findings indicate that P. falciparum is of gorilla origin and not of chimpanzee, bonobo or ancient human origin...
- Hybrid origin of SIV in chimpanzeesElizabeth Bailes
University of Nottingham, Nottingham NG72UH, UK
Science 300:1713. 2003
- Frequent simian foamy virus infection in persons occupationally exposed to nonhuman primatesWilliam M Switzer
HIV and Retrovirology Branch, Division of AIDS, STD, and TB Laboratory Research, National Center for HIV, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
J Virol 78:2780-9. 2004..Our data highlight the importance of studies to better define the public health implications of zoonotic SFV infections...
- Molecular ecology and natural history of simian foamy virus infection in wild-living chimpanzeesWeimin Liu
Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
PLoS Pathog 4:e1000097. 2008....
- Diverse contexts of zoonotic transmission of simian foamy viruses in AsiaLisa Jones-Engel
Division of International Programs, National Primate Research Center, University of Washington, Seattle, Washington 98195, USA
Emerg Infect Dis 14:1200-8. 2008..Thus, SFV infections are likely to be prevalent among persons who live or work near nonhuman primates in Asia...
- Screening for simian foamy virus infection by using a combined antigen Western blot assay: evidence for a wide distribution among Old World primates and identification of four new divergent virusesAlthaf I Hussain
HIV and Retrovirology Branch, Division of AIDS, STD, and TB Laboratory Research, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
Virology 309:248-57. 2003..These results demonstrate the ability of the CA-WB assay to detect infection in a large number of NHP species, including previously uncharacterized infections with divergent SFVs...
- Catastrophic ape decline in western equatorial AfricaPeter D Walsh
Department of Ecology and Evolutionary Biology, Guyot Hall, Princeton, New Jersey 08540, USA
Nature 422:611-4. 2003..Without aggressive investments in law enforcement, protected area management and Ebola prevention, the next decade will see our closest relatives pushed to the brink of extinction...
- Descriptive epidemiology of fatal respiratory outbreaks and detection of a human-related metapneumovirus in wild chimpanzees (Pan troglodytes) at Mahale Mountains National Park, Western TanzaniaTaranjit Kaur
Department of Biomedical Sciences and Pathobiology, Virginia Maryland Regional College of Veterinary Medicine, Virginia Tech, Blacksburg, Virginia 24061, USA
Am J Primatol 70:755-65. 2008..In addition, descriptive epidemiology should be a major component of disease outbreak investigations...
- SIVcpz in wild chimpanzeesMario L Santiago
University of Alabama at Birmingham, Birmingham, AL 35294 6024, USA
Science 295:465. 2002
- Wild chimpanzees infected with 5 Plasmodium speciesMarco Kaiser
Robert Koch Institute, Berlin, Germany
Emerg Infect Dis 16:1956-9. 2010..We surveyed Plasmodium spp. diversity in wild chimpanzees living in an undisturbed tropical rainforest habitat and found 5 species: P. malariae, P. vivax, P. ovale, P. reichenowi, and P. gaboni...
- Multiple Ebola virus transmission events and rapid decline of central African wildlifeEric M Leroy
Institut de Recherche pour le Developpement, UR034, Centre International de Recherches Medicales de Franceville, BP 769 Franceville, Gabon
Science 303:387-90. 2004..Surveillance of animal mortality may help to predict and prevent human Ebola outbreaks...
- Natural simian foamy virus infection in wild-caught gorillas, mandrills and drills from Cameroon and GabonSara Calattini
Unité d Epidémiologie et Physiopathologie des Virus Oncogènes, Département EMMI, Institut Pasteur, Paris, France
J Gen Virol 85:3313-7. 2004....
- Noninvasive monitoring of respiratory viruses in wild chimpanzeesSophie Köndgen
Robert Koch Institut, Berlin, Germany
Ecohealth 7:332-41. 2010..The methods presented here may also be applied for the investigation of further acute diseases in great apes and other species...
- Identification of Plasmodium malariae, a human malaria parasite, in imported chimpanzeesToshiyuki Hayakawa
Laboratory of Malariology, International Research Center of Infectious Diseases, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan
PLoS ONE 4:e7412. 2009..malariae infection in humans. To our knowledge, this is the first to report P. malariae infection in chimpanzees and a human malaria parasite from nonhuman primates imported to a nonendemic country...
- Chimpanzee malaria parasites related to Plasmodium ovale in AfricaLinda Duval
Laboratoire de Biologie fonctionnelle des protozoaires, USM 504, Museum national d histoire naturelle, Paris, France
PLoS ONE 4:e5520. 2009..ovale strains isolated from humans. This study provides the first evidence of possibility of natural cross-species exchange of P. ovale between humans and chimpanzees of the subspecies Pan t. troglodytes...
- Lethal pneumonia in a captive juvenile chimpanzee (Pan troglodytes) due to human-transmitted human respiratory syncytial virus (HRSV) and infection with Streptococcus pneumoniaeClaudia A Szentiks
Leibniz Institute for Zoo and Wildlife Research, Berlin, Germany
J Med Primatol 38:236-40. 2009..One infant female chimpanzee with severe respiratory symptoms died despite immediate medical treatment and was submitted for necropsy...
- Pandemic human viruses cause decline of endangered great apesSophie Köndgen
Robert Koch Institut, Nordufer 20, D 13353 Berlin, Germany
Curr Biol 18:260-4. 2008..These observations illustrate the challenge of maximizing the benefit of research and tourism to great apes while minimizing the negative side effects...
- Molecular epidemiology of simian T-lymphotropic virus (STLV) in wild-caught monkeys and apes from Cameroon: a new STLV-1, related to human T-lymphotropic virus subtype F, in a Cercocebus agilisE Nerrienet
Centre Pasteur du Cameroun, BP 1274, , Cameroon
J Gen Virol 82:2973-7. 2001....
- Ebola virus outbreak among wild chimpanzees living in a rain forest of Côte d'IvoireP Formenty
World Health Organization WHO Taï Forest Project, and Centre Suisse de recherches scientifiques, Abidjan, Cote d Ivoire
J Infect Dis 179:S120-6. 1999..A high mortality rate among apes tends to indicate that they are not the reservoir for the disease causing the illness. These points will have to be investigated by additional studies...
- Detection and molecular characterization of foamy viruses in Central African chimpanzees of the Pan troglodytes troglodytes and Pan troglodytes vellerosus subspeciesSara Calattini
Unité d Epidémiologie et Physiopathologie des Virus Oncogènes, Département EEMI, Institut Pasteur, Paris, France
J Med Primatol 35:59-66. 2006..This zoonotic infection was demonstrated mainly after bites by chimpanzees [Pan troglodytes (P. t.)] of the West African P. t. verus subspecies in primatology centers or zoos in the USA...
- Transmission of human and macaque Plasmodium spp. to ex-captive orangutans in Kalimantan, IndonesiaMichael J C Reid
Simon Fraser University, Burnaby, British Columbia, Canada
Emerg Infect Dis 12:1902-8. 2006..These data have potential implications for the conservation of orangutans and also for the bidirectional transmission of parasites between orangutans and humans visiting or living in the region...
- Characterization of Bacillus anthracis-like bacteria isolated from wild great apes from Cote d'Ivoire and CameroonSilke R Klee
Robert Koch Institut, Centre for Biological Safety 2, Nordufer 20, 13353 Berlin, Germany
J Bacteriol 188:5333-44. 2006..We propose that the newly discovered atypical B. anthracis strains share a common ancestor with classic B. anthracis or that they emerged recently by transfer of the B. anthracis plasmids to a strain of the B. cereus group...
- The epidemiology of simian immunodeficiency virus infection in a large number of wild- and captive-born chimpanzees: evidence for a recent introduction following chimpanzee divergenceWilliam M Switzer
HIV and Retrovirology Branch, Division of HIV AIDS Prevention, National Center for HIV, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
AIDS Res Hum Retroviruses 21:335-42. 2005..The absence of SIVcpz infection in P. t. verus suggests that SIVcpz may not be endemic to this subspecies and implies that SIVcpz may have been introduced more recently into the chimpanzee subspecies following divergence...
- Non-invasive body temperature measurement of wild chimpanzees using fecal temperature declineSiv Aina Jensen
Max Planck Institute for Evolutionary Anthropology, Leipzig 04103, Germany
J Wildl Dis 45:542-6. 2009..The method was successfully applied and the average estimated temperature of the chimpanzees was 37.2 C. This simple-to-use field method reliably estimates the body temperature of wild chimpanzees and probably also other large mammals...
- Orangutans not infected with Plasmodium vivax or P. cynomolgi, IndonesiaBalbir Singh
Malaria Research Centre, Universiti Malaysia Sarawak, Sarawak, Malaysia
Emerg Infect Dis 15:1657-8. 2009..We found that these orangutans are not hosts of P. cynomolgi and P. vivax. Analysis of >or=1 genes is needed to identify Plasmodium spp. infecting orangutans...
- Anthrax, but not Bacillus anthracis?Richard Okinaka
Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America
PLoS Pathog 2:e122. 2006
- Anthrax in Western and Central African great apesFabian H Leendertz
Great Ape Health Monitoring Unit, c o Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
Am J Primatol 68:928-33. 2006....
- Simian T-cell leukemia virus (STLV) infection in wild primate populations in Cameroon: evidence for dual STLV type 1 and type 3 infection in agile mangabeys (Cercocebus agilis)Valerie Courgnaud
UR36, IRD, and University of Montpellier I, Montpellier, France
J Virol 78:4700-9. 2004....
- Fruit bats as reservoirs of Ebola virusEric M Leroy
Centre International de Recherches Medicales de Franceville, BP 769 Franceville, Gabon
Nature 438:575-6. 2005..We find evidence of asymptomatic infection by Ebola virus in three species of fruit bat, indicating that these animals may be acting as a reservoir for this deadly virus...
- Non-invasive testing reveals a high prevalence of simian T-lymphotropic virus type 1 antibodies in wild adult chimpanzees of the Taï National Park, Côte d'IvoireFabian H Leendertz
Zentrum für Biologische Sicherheit, Robert Koch Institut, Nordufer 20, 13353 Berlin, Germany
J Gen Virol 85:3305-12. 2004..The prevalence of STLV-1 antibodies in adults and adolescents was significantly higher (35/49, 71.4 %) than that in infant and juvenile chimpanzees (3/31, 9.7 %)...
- Climate-based health monitoring systems for eco-climatic conditions associated with infectious diseasesE Pinzon
Science Systems and Applications, Inc SSAI, USA
Bull Soc Pathol Exot 98:239-43. 2005..This article provides a condensed, and selective look at classical material and recent research about remote sensing and GIS (geographic information system) applications in public health...
- A serological survey of Ebola virus infection in central African nonhuman primatesE M Leroy
Centre International de Recherches Medicales de Franceville, Institut de Recherche pour le Developpement, UR034, Franceville, Gabon
J Infect Dis 190:1895-9. 2004..They also suggest that future Ebola outbreaks may occur anywhere in the central African forest region...
- The potential significance of adaptive evolution and dimerization in chimpanzee intercellular cell adhesion molecules (ICAMs)Nicole A R Walter
Evolutionary Genomics, Colorado Bioscience Park Center, 12635 East Montview Boulevard, Aurora, Colorado 80010, USA
J Theor Biol 232:339-46. 2005....
- Contrasting histories of G6PD molecular evolution and malarial resistance in humans and chimpanzeesBrian C Verrelli
Center for Evolutionary Functional Genomics, The Biodesign Institute, Tempe, Arizona, USA
Mol Biol Evol 23:1592-601. 2006..These comparative analyses suggest that the recent signature of positive selection at G6PD in humans is unique...
- Novel polyomavirus detected in the feces of a chimpanzee by nested broad-spectrum PCRReimar Johne
Institute for Virology, Faculty of Veterinary Medicine, University of Leipzig, An den Tierkliniken 29, D 04103 Leipzig, Germany
J Virol 79:3883-7. 2005....
- Molecular evidence for the infection of zoo chimpanzees by pig AscarisPeter Nejsum
Danish Centre for Experimental Parasitology, The Royal Veterinary and Agricultural University, Dyrlaegevej 100, DK 1870, Frederiksberg C, Copenhagen, Denmark
Vet Parasitol 139:203-10. 2006..Pigs as a potential source of Ascaris infections for both captive and wild chimpanzees and other animals, therefore needs to be considered and appropriate steps taken to prevent such infection...
- Ebola and great apes in Central Africa: current status and future needsW Karesh
Field Veterinary Program Wildlife Conservation Society, 2300 Southern Blvd, Bronx, NY 10460, USA
Bull Soc Pathol Exot 98:237-8. 2005
- Posaconazole therapy for systemic coccidioidomycosis in a chimpanzee (Pan troglodytes): a case reportKimberly Vinette Herrin
Mycoses 48:447-52. 2005..immitis serum antibody titre was noted. The successful suppression of coccidioidomycosis observed in this chimpanzee suggests that posaconazole may have a role in the treatment of CNS infections caused by susceptible fungi...
- Evolutionary relationships of "Candidatus Riesia spp.," endosymbiotic enterobacteriaceae living within hematophagous primate liceJulie M Allen
Zoology Department, Florida Museum of Natural History, University of Florida, Dickinson Hall, Gainesville, FL 32611, USA
Appl Environ Microbiol 73:1659-64. 2007..Given the evidence for cospeciation with primate lice and the evidence for fast evolutionary rates, this lineage of endosymbiotic bacteria can be evaluated as a fast-evolving marker of both louse and primate evolutionary histories...
- Sharing malariasN J White
Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand
Lancet 363:1006. 2004
- Clinical and pathologic manifestation of oesophagostomosis in African great apes: does self-medication in wild apes influence disease progression?Sabrina Krief
USM 104 Eco anthropologie et Ethnobiologie, Département Hommes, Natures, sociétés, Museum national d histoire naturelle, Paris, France
J Med Primatol 37:188-95. 2008....
- Hepatitis C virus JFH-1 strain infection in chimpanzees is associated with low pathogenicity and emergence of an adaptive mutationTakanobu Kato
Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA
Hepatology 48:732-40. 2008..A common mutation G838R in the NS2 region emerged early in both chimpanzees. This mutation enhances viral assembly, leading to an increase in viral production in transfected or infected cells...
- Specific nature of cellular immune responses elicited by chimpanzees against HIV-1Sunita S Balla-Jhagjhoorsingh
Department of Virology, Biomedical Primate Research Centre, Rijswijk, The Netherlands
Hum Immunol 64:681-8. 2003..Here we review the characteristics of the HIV-1-specific cell-mediated immune responses mounted by chimpanzees, and we postulate the mechanisms that have evolved that facilitate their resistance to acquired immunodeficiency syndrome...
- Hepatitis C virus p7 protein is crucial for assembly and release of infectious virionsEike Steinmann
Department of Molecular Virology, University of Heidelberg, Heidelberg, Germany
PLoS Pathog 3:e103. 2007....
- Characterization of a new simian T-lymphocyte virus type 1 (STLV-1) in a wild living chimpanzee (Pan troglodytes verus) from Ivory Coast: evidence of a new STLV-1 group?Fabian H Leendertz
Retrovirology, Robert Koch Institut, Berlin, Germany
AIDS Res Hum Retroviruses 19:255-8. 2003..The tax sequences reveal two sequence differences that seem to be unique as they are not found in any of the HTLV-1 or STLV-1 tax sequences from the public databases...
- Chimpanzee reservoirs of pandemic and nonpandemic HIV-1Brandon F Keele
Departments of Medicine and Microbiology, University of Alabama at Birmingham, Birmingham, AL, USA
Science 313:523-6. 2006..These findings establish P. t. troglodytes as a natural reservoir of HIV-1...
- Nevus lipomatosus cutaneus superficialis (Hoffmann-Zurhelle) in a chimpanzee (Pan troglodytes)Robert Klopfleisch
Friedrich Loeffler Institut, Federal Research Institute for Animal Health, Greifswald Insel Riems, Germany
J Med Primatol 36:57-60. 2007..After surgical removal, the mass recurred and extended progressively over a period of 5 years...
- Conservation biology. Ebola, hunting push ape populations to the brinkJocelyn Kaiser
Science 300:232. 2003
- Potential for Ebola transmission between gorilla and chimpanzee social groupsPeter D Walsh
Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, 04103 Leipzig, Germany
Am Nat 169:684-9. 2007..These observations support a reassessment of ape-to-ape transmission as an amplifier of Ebola outbreaks...
- Reduced transmission and prevalence of simian T-cell lymphotropic virus in a closed breeding colony of chimpanzees (Pan troglodytes verus)H Niphuis
Department of Virology, Biomedical Primate Research Centre, Lange Kleiweg 139, 2288 GJ Rijswijk, The Netherlands
J Gen Virol 84:615-20. 2003..In contrast, transmission from infected mother to child was not observed, suggesting that this is not a common route of transmission for STLV in this species, which is in contrast to HTLV-1 in humans...
- Epidemiology. Ebola outbreaks may have had independent sourcesGretchen Vogel
Science 303:298-9. 2004
- Cholesterol values in free-ranging gorillas (Gorilla gorilla gorilla and Gorilla beringei) and Bornean orangutans (Pongo pygmaeus)Debra A Schmidt
Lincoln Park Zoo, Chicago, Illinois 60614, USA
J Zoo Wildl Med 37:292-300. 2006..The higher total cholesterol and low-density lipoprotein cholesterol concentrations in captive apes may predispose them to cardiovascular disease and might be attributed to diets, limited energy expenditure, and genetics...
- Wild animal mortality monitoring and human Ebola outbreaks, Gabon and Republic of Congo, 2001-2003Pierre Rouquet
Centre International de Recherches Medicales de Franceville, CIRMF BP 769, Franceville, Gabon
Emerg Infect Dis 11:283-90. 2005..Wild animal outbreaks began before each of the 5 human Ebola outbreaks. Twice we alerted the health authorities to an imminent risk for human outbreaks, weeks before they occurred...
- A new entodiniomorphid ciliate, Troglocorys cava n. g., n. sp., from the wild eastern chimpanzee (Pan troglodytes schweinfurthii) from UgandaToshihiro Tokiwa
Department of Parasitology, Nippon Veterinary and Life Science University, Musashino, Tokyo 180 8602, Japan
J Eukaryot Microbiol 57:115-20. 2010....
- Reactivation of lymphocryptovirus (Epstein-Barr virus chimpanzee) and dominance in chimpanzeesRain Yamamoto
Department of Biological Sciences, Graduate School of Science, University of Tokyo, Hongo, Bunkyo ku, Tokyo 113 0033, Japan
J Gen Virol 91:2049-53. 2010..001). The effect of the male dominance rank did not differ between the pre-Form and post-Form periods (t=-1.557, P=0.12). Reactivation of LCV (EBV) as an immunological stress marker for humans might also be applied to chimpanzees...
- Debilitating clinical disease in a wild-born captive western lowland gorilla (Gorilla gorilla gorilla) co-infected with varicella zoster virus (VZV) and simian T-lymphotropic virus (STLV)Nicholas Masters
International Zoo Veterinary Group, Keighley Business Centre, South Street, Keighley, West Yorkshire, BD21 1AG, United Kingdom
J Zoo Wildl Med 41:713-6. 2010..It is hypothesized that recrudescence of VZV and other disease processes described were associated with chronic STLV infection and the end of a characteristically long incubation period...
- Monitoring of hepatitis C virus quasispecies in chronic infection by matrix-assisted laser desorption ionization-time of flight mass spectrometry mutation detectionCarmen Yea
Metabolism Research Program, The Hospital for Sick Children, Toronto, Canada
J Clin Microbiol 45:1053-7. 2007..We also used the mass spectrometry method in the clinical follow-up of a chronically infected patient over a 5-year period...
- Acute appendicitis in a chimpanzee (Pan troglodytes)Jennifer D'Agostino
College of Veterinary Medicine, The Veterinary Medical Teaching Hospital, Kansas State University, Manhattan, KS, USA
J Med Primatol 36:119-23. 2007..An irregular, mineral opacity was identified in the caudal right quadrant of the abdomen on radiographs and computed tomography scan, which appeared to be in the region of the cecal appendage...
- Identification of a hepatitis B virus genome in wild chimpanzees (Pan troglodytes schweinfurthi) from East Africa indicates a wide geographical dispersion among equatorial African primatesJean Pierre Vartanian
Unite de Retrovirologie Moleculaire, Institut Pasteur, Paris, France
J Virol 76:11155-8. 2002..An entire hepatitis B virus (HBV) genome was amplified and sequenced from samples taken from one animal. This indicates that HBV is distributed across the entire range of chimpanzee habitats...
- Leucoencephalopathy with cerebral calcinosis in a young chimpanzee (Pan troglodytes) - a case reportM Zoller
Department of Infectious Pathology, German Primate Center, Gottingen, Germany
J Med Primatol 36:385-90. 2007..A 4-year-old chimpanzee (Pan troglodytes) had a clinical history of a 2-year progressive central nervous dysfunction including convulsions and severe paralysis...
- Presence and species identification of the gapeworm Mammomonogamus laryngeus (Railliet, 1899) (Syngamidae: Nematoda) in a semi-wild population of Sumatran orangutan (Pongo abelii) in IndonesiaI Foitova
Institute of Botany and Zoology, Masaryk University, Kotlarska 2, 61137, Brno, Czech Republic
Res Vet Sci 84:232-6. 2008..Coprological monitoring of infection in rehabilitants in this area as well as among the wild population of orangutan is necessary...
- CD4+ immune escape and subsequent T-cell failure following chimpanzee immunization against hepatitis C virusMontserrat Puig
Laboratory of Hepatitis Viruses, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
Hepatology 44:736-45. 2006..Vaccines that can induce strong T-cell responses prior to challenge will not necessarily prevent persistent HCV infection...
- Morphological variability within Oesophagostomum bifurcum among different primate species from GhanaJ M de Gruijter
Department of Parasitology, Leiden University Medical Centre, University of Leiden, PO Box 9600, 2300 RC Leiden, The Netherlands
J Helminthol 80:357-61. 2006..These findings suggest that O. bifurcum from different species of primate host represent distinct population variants, also supported by recent epidemiological and genetic studies of O. bifurcum from such hosts...
- Using retrospective health data from the Gombe chimpanzee study to inform future monitoring effortsE V Lonsdorf
Center for the Study and Conservation of Apes, Department of Conservation and Science, Lincoln Park Zoo, Chicago, Illinois 60614, USA
Am J Primatol 68:897-908. 2006..Here we present the types of data found during the survey, discuss the usefulness of these data in the context of risk assessment, and describe how our current monitoring effort at Gombe was designed based on our findings...
- Intestinal parasite infections and fecal steroid levels in wild chimpanzeesMichael P Muehlenbein
Department of Anthropology, University of Wisconsin Milwaukee, Milwaukee, Wisconsin 53211, USA
Am J Phys Anthropol 130:546-50. 2006..The utility of fecal samples for assessing immune-endocrine interactions is discussed...
- Sequence analysis of a highly divergent HIV-1-related lentivirus isolated from a wild captured chimpanzeeM M Vanden Haesevelde
Innogenetics N V, Industriepark 7, Gent, Belgium
Virology 221:346-50. 1996..Our data suggest multiple introductions of HIV-1 in the human population and shed new light on the origin of the HIV-1 pandemic...
- Linear enamel hypoplasia in the great apes: analysis by genus and localityDarcy Lee Hannibal
Department of Anthropology, University of Oregon, Eugene, Oregon 97403, USA
Am J Phys Anthropol 127:13-25. 2005..It is likely that both biological and environmental factors influence the high frequencies of enamel hypoplasia exhibited in the great apes...
- Hepatitis C virus kinetics and host responses associated with disease and outcome of infection in chimpanzeesMarian E Major
Laboratory of Hepatitis Viruses, Division of Viral Products Center for Biologics Evaluation and Research Food and Drug Administration, Bethesda, MD, USA
Hepatology 39:1709-20. 2004..However, the pathogenesis of HCV may be determined by a more rapid onset of the induced response and the cell population that migrates to the liver...
- CpG DNA overcomes hyporesponsiveness to hepatitis B vaccine in orangutansH L Davis
Loeb Health Research Institute at the Ottawa Hospital, 725 Parkdale Avenue, Ottawa, Canada
Vaccine 18:1920-4. 2000..This is the first demonstration of CpG DNA in a great ape and the results have important implications for the vaccination of humans against HBV and other diseases...
- A single genotype of Encephalitozoon intestinalis infects free-ranging gorillas and people sharing their habitats in UgandaThaddeus K Graczyk
The W Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
Parasitol Res 88:926-31. 2002..intestinalis. It is highly unlikely that these two identical Enc. intestinalis genotypes were acquired independently by gorillas and people; it is much more probable that one group initiated infection of the other...
- Endoparasites of western lowland gorillas (Gorilla gorilla gorilla) at Bai Hokou, Central African RepublicAndrea S Freeman
Field Veterinary Program, Wildlife Conservation Society, 185th Street and Southern Boulevard, Bronx, New York 10460, USA
J Wildl Dis 40:775-81. 2004..With the advent of ecotourism in this study area, continued monitoring is indicated for insuring the health of both gorillas and humans in the Bai Hokou study area...
- Cataract surgery with foldable intraocular lens implants in captive lowland gorillas (Gorilla gorilla gorilla)J T H N de Faber
Rotterdam Eye Hospital, 3011 BH Rotterdam, The Netherlands
J Zoo Wildl Med 35:520-4. 2004..This animal developed bilateral after-cataract and therefore needed a second intervention in both eyes using Nd:YAG laser treatment. The genetic component of juvenile cataracts should be considered in breeding management programs...
- Intestinal parasites found in the research group of mountain gorillas in Bwindi Impenetrable National Park, Uganda: preliminary resultsJessica M Rothman
Cornell University, Ithaca New York 14853, USA
Ann N Y Acad Sci 969:346-9. 2002..An increasing threat to this group of gorillas is the presence of local field assistants and researchers. We found no evidence of human parasites in the fecal samples from this gorilla group...
- Simian T cell leukaemia virus type I subtype B in a wild-caught gorilla (Gorilla gorilla gorilla) and chimpanzee (Pan troglodytes vellerosus) from CameroonEric Nerrienet
Laboratoire de Virologie, Centre Pasteur du Cameroun, , Cameroon
J Gen Virol 85:25-9. 2004..Such findings reinforce the hypothesis of interspecies transmission of STLV-I to humans, leading to the present day distribution of HTLV-I in central African inhabitants...
- Effects of repeated anthelmintic treatment on Enterobius vermicularis infection in chimpanzeesTadao Nakano
Department of Infectious Diseases, Faculty of Medicine, Oita University, Hasama, Oita 879 5593, Japan
J Parasitol 91:679-82. 2005..Complete eradication was not achieved, however, presumably because of reinfection. The female proportion among discharged worms tended to increase as the treatment was repeated...
- Chronic hepatitis C virus infection established and maintained in chimpanzees independent of dendritic cell impairmentChristine Rollier
Department of Virology, Biomedical Primate Research Centre, 2280 GH Rijswijk, The Netherlands
Hepatology 38:851-8. 2003..Indeed, the maturation and allostimulatory impairment, as described in patient studies, are not necessary prerequisites but rather possible consequences of persistent and active HCV infection associated with disease progression...
- Neoplasia in the chimpanzee (Pan spp.)S L Brown
Southwest National Primate Research Center at the Southwest Foundation for Biomedical Research, San Antonio, TX 78245 0549, USA
J Med Primatol 38:137-44. 2009..There is minimal information concerning cancer in the chimpanzee and such information would be valuable to individuals caring for and using them for research...
- Environmental management procedures following fatal melioidosis in a captive chimpanzee (Pan troglodytes)Angkana Sommanustweechai
Bureau of Research, Conservation and Education, Zoological Park Organization, Bangkok 10300, Thailand
J Zoo Wildl Med 44:475-9. 2013..pseudomallei. Following the soil treatment in the exhibit, all chimpanzees have remained free of clinical signs consistent with melioidosis...
- Scheuermann kyphosis in nonhuman primatesBrian M Farrell
St Mary s Medical Center, San Francisco, CA 94117, USA
Spine (Phila Pa 1976) 37:E1432-7. 2012..A cadaveric survey of the thoracic spines of extant species of nonbipedal primates for the presence of Scheuermann kyphosis...
- Clinical management of a western lowland gorilla (Gorilla gorilla gorilla) with a cardiac resynchronization therapy deviceElizabeth Marie Rush
Birmingham Zoo, Inc, 2630 Cahaba Road, Birmingham, Alabama 35223, USA
J Zoo Wildl Med 42:263-76. 2011..This describes the comprehensive medical, husbandry, and training techniques necessary to successfully manage this intense clinical case in conjunction with intracardiac device therapy...
- Origins of HIV and the AIDS pandemicPaul M Sharp
Institute of Evolutionary Biology and Centre for Immunity, Infection and Evolution, University of Edinburgh, Edinburgh EH9 3JT, United Kingdom
Cold Spring Harb Perspect Med 1:a006841. 2011..Tracing the genetic changes that occurred as SIVs crossed from monkeys to apes and from apes to humans provides a new framework to examine the requirements of successful host switches and to gauge future zoonotic risk...
- African Plasmodium vivax: distribution and originsRichard Culleton
Malaria Unit, Institute of Tropical Medicine NEKKEN, Nagasaki University, Nagasaki, Japan
Int J Parasitol 42:1091-7. 2012..vivax as a human parasite. With the support of new evidence from mitochondrial genome sequencing, we propose that the evidence is consistent with current, extant P. vivax populations having their origins in Africa...
- Probable transmission of coxsackie B3 virus from human to chimpanzee, DenmarkSandra C Abel Nielsen
University of Copenhagen, Copenhagen, Denmark
Emerg Infect Dis 18:1163-5. 2012..Identification of coxsackie B3 virus, a common human pathogen, as the causative agent, and its severe manifestation, raise questions about pathogenicity and transmissibility among humans and other primates...
- Identification and molecular characterization of new STLV-1 and STLV-3 strains in wild-caught nonhuman primates in CameroonFlorian Liegeois
UMR 145, Institut de Recherche pour le Developpement IRD and University of Montpellier 1, Montpellier, France
Virology 371:405-17. 2008..cephus. Finally, we identify relative divergence levels in the tax/rex phylogeny suggesting that additional types of PTLV should be defined, particularly for the highly divergent STLV-1(MarB43) strain that we provisionally name STLV-5...
- Validation of multiple diagnostic techniques to detect Cryptosporidium sp. and Giardia sp. in free-ranging western lowland gorillas (Gorilla gorilla gorilla) and observations on the prevalence of these protozoan infections in two populations in GabonMartine van Zijll Langhout
Mikongo Conservation Centre, Lope National Park, Gabon
J Zoo Wildl Med 41:210-7. 2010..and Giardia sp. infections in free-ranging western lowland gorillas and highlights the importance of verifying the accuracy of diagnostic techniques developed for human use before applying these to non-human primates...
- Scoliosis in an OrangutanSatyajit B Naique
Imperial College School of Medicine, Charing Cross Hospital, London, United Kingdom
Spine (Phila Pa 1976) 28:E143-5. 2003..The first case of scoliosis in an Orangutan spine is reported...
- Tetraparesis resembling acute transverse myelitis in a captive chimpanzee (Pan troglodytes): long-term care and recoveryT Miyabe-Nishiwaki
Center for Human Evolution Modeling Research, Primate Research Institute, Kyoto University, Inuyama, Aichi, Japan
J Med Primatol 39:336-46. 2010..Magnetic resonance imaging showed a diffuse T2-weighted hyperintensive lesion, indicating inflammation at the C1-2 level. All infective, autoimmune, and vascular investigations were unremarkable...
- Causes of death in the Kasekela chimpanzees of Gombe National Park, TanzaniaJ M Williams
The Jane Goodall Institute s Center for Primate Studies, Department of Ecology, Evolution and Behavior, University of Minnesota, St Paul, Minnesota, USA
Am J Primatol 70:766-77. 2008..Intercommunity lethal aggression involving the Kasekela community was observed most frequently during two periods. Other less common causes of death included injury, loss of mother, maternal disability, and poaching...
- Successful transabdominal subxiphoid pericardiostomy to relieve chronic pericardial effusion in a Sumatran orangutan (Pongo abelli)P K Robbins
Veterinary Services, San Diego Zoo, 1354 Old Globe Way, San Diego, California 92101, USA
J Zoo Wildl Med 40:564-7. 2009..Transabdominal subxiphoid pericardiostomy offers a straightforward surgical approach that can provide significant relief in cases of chronic pericardial effusion in great apes...
- Medical and surgical management of reproductive neoplasia in two western lowland gorillas (Gorilla gorilla gorilla)Elizabeth M Stringer
North Carolina State University, College of Veterinary Medicine, Raleigh, NC 27606, USA
J Med Primatol 39:328-35. 2010..Reports of female reproductive tract neoplasia are infrequent in great apes...
- A genetic variant of hepatitis B virus divergent from known human and ape genotypes isolated from a Japanese patient and provisionally assigned to new genotype JKanako Tatematsu
Department of Clinical Molecular Informative Medicine, Nagoya, City University Graduate School of Medical Sciences, Mizuho, Nagoya, Japan
J Virol 83:10538-47. 2009..Since HBV/J is positioned phylogenetically in between human and ape genotypes, it may help to trace the origin of HBV and merits further epidemiological surveys...
- Isolation and phylogenetic characterization of Ebola viruses causing different outbreaks in GabonM C Georges Courbot
, Franceville, Gabon
Emerg Infect Dis 3:59-62. 1997..As in earlier Ebola virus outbreaks, no genetic variability was detected between virus samples taken during an individual outbreak...
- Evaluation of accumulation of hepatitis C virus mutations in a chronically infected chimpanzee: comparison of the core, E1, HVR1, and NS5b regionsL Lu
Hepatitis Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
J Virol 75:3004-9. 2001..In the core and E1 regions, synonymous substitutions predominated and gradually increased over time. However, within the HVR1 region, nonsynonymous substitutions predominated but gradually decreased over time...
- Management of hepatitis B virus infections in two gibbons and a western lowland gorilla in a zoological collectionS M Thornton
Veterinary Science Unit, Institute of Zoology, Zoological Society of London
Vet Rec 149:113-5. 2001....
- Longitudinal comparison of virus load parameters and CD8 T-cell suppressive capacity in two SIVcpz-infected chimpanzeesP Ondoa
Institute of Tropical Medicine, Antwerp, Belgium
J Med Primatol 30:243-53. 2001....
- [The origin and evolution of HIV]Jun Takehisa
Department of Medicine, University of Alabama at Birmingham, USA
Nihon Rinsho 68:410-4. 2010..Second, in vitro studies demonstrate that SIVcpz and SIVgor have many of the biological properties necessary for establishing a persistent infection in humans...
- Uterine adenomyosis in an orang-utan (Pongo abelii/pygmaeus)K J Graham
North Shore Veterinary Specialist Centre, Crows Nest, New South Wales 2065, Australia
Aust Vet J 87:66-9. 2009....
- Chimpanzees in hepatitis C virus research: 1998-2007R H Bettauer
Bettauer BioMed Research, Mc Lean, VA, USA
J Med Primatol 39:9-23. 2010..Chimpanzees have been widely used in hepatitis C virus (HCV) research, but their endangered status and high financial and ethical costs have prompted a closer review...
- Conservation biology. Can great apes be saved from Ebola?Gretchen Vogel
Science 300:1645. 2003
- Isolates of Zaire ebolavirus from wild apes reveal genetic lineage and recombinantsTatiana J Wittmann
Centre International de Recherches Medicales de Franceville, BP 769 Franceville, Gabon
Proc Natl Acad Sci U S A 104:17123-7. 2007..The potential for recombination adds an additional level of complexity to unraveling and potentially controlling the emergence of ZEBOV in humans and wildlife species...
- Dientamoeba fragilis: initial evidence of pathogenicity in the western lowland gorilla (Gorilla gorilla gorilla)Felix Lankester
Limbe Wildlife Centre, Limbe Botanic Garden Street, Limbe, South West Region, Cameroon
J Zoo Wildl Med 41:350-2. 2010..The report suggests that metronidazole was effective because it eliminated the protozoa, Dientamoeba fragilis. Dientamoeba fragilis should be considered on the differential diagnosis list of any captive gorilla with IBS-like symptoms...
- PROPHYLACTIC & THERPEUTIC DNA IMMUNIZATION AGAINST HCVAlfred Prince; Fiscal Year: 2003..The immunogenicity of HCV genes presented as fusion proteins with ubiquitin and secreting and non-secreting HCV gene-containing plasmids will be compared. ..
- Calorie Restriction Effects on Chromosomal AberrationsCHARLEEN MOORE; Fiscal Year: 2003..The results will be essential in identifying potential mechanisms by which CR acts in cancer prevention and delay of the aging process in long-lived species such as the rhesus monkey and humans. ..
- Primate enteroviruses transmission in BangladeshLisa Jones Engel; Fiscal Year: 2007..Ultimately, this data will provide insight into the potential emergence of NHP-borne pathogens and help to deter the spread of emerging zoonotic threats. [unreadable] [unreadable]..