ape diseases

Summary

Summary: Diseases of chimpanzees, gorillas, and orangutans.

Top Publications

  1. pmc Origin of the human malaria parasite Plasmodium falciparum in gorillas
    Weimin Liu
    Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Nature 467:420-5. 2010
  2. ncbi Hybrid origin of SIV in chimpanzees
    Elizabeth Bailes
    University of Nottingham, Nottingham NG72UH, UK
    Science 300:1713. 2003
  3. pmc Frequent simian foamy virus infection in persons occupationally exposed to nonhuman primates
    William M Switzer
    HIV and Retrovirology Branch, Division of AIDS, STD, and TB Laboratory Research, National Center for HIV, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Virol 78:2780-9. 2004
  4. pmc Molecular ecology and natural history of simian foamy virus infection in wild-living chimpanzees
    Weimin Liu
    Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
    PLoS Pathog 4:e1000097. 2008
  5. pmc Diverse contexts of zoonotic transmission of simian foamy viruses in Asia
    Lisa Jones-Engel
    Division of International Programs, National Primate Research Center, University of Washington, Seattle, Washington 98195, USA
    Emerg Infect Dis 14:1200-8. 2008
  6. ncbi Screening for simian foamy virus infection by using a combined antigen Western blot assay: evidence for a wide distribution among Old World primates and identification of four new divergent viruses
    Althaf I Hussain
    HIV and Retrovirology Branch, Division of AIDS, STD, and TB Laboratory Research, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Virology 309:248-57. 2003
  7. ncbi Catastrophic ape decline in western equatorial Africa
    Peter D Walsh
    Department of Ecology and Evolutionary Biology, Guyot Hall, Princeton, New Jersey 08540, USA
    Nature 422:611-4. 2003
  8. ncbi Descriptive epidemiology of fatal respiratory outbreaks and detection of a human-related metapneumovirus in wild chimpanzees (Pan troglodytes) at Mahale Mountains National Park, Western Tanzania
    Taranjit Kaur
    Department of Biomedical Sciences and Pathobiology, Virginia Maryland Regional College of Veterinary Medicine, Virginia Tech, Blacksburg, Virginia 24061, USA
    Am J Primatol 70:755-65. 2008
  9. ncbi SIVcpz in wild chimpanzees
    Mario L Santiago
    University of Alabama at Birmingham, Birmingham, AL 35294 6024, USA
    Science 295:465. 2002
  10. pmc Wild chimpanzees infected with 5 Plasmodium species
    Marco Kaiser
    Robert Koch Institute, Berlin, Germany
    Emerg Infect Dis 16:1956-9. 2010

Research Grants

Detail Information

Publications150 found, 100 shown here

  1. pmc Origin of the human malaria parasite Plasmodium falciparum in gorillas
    Weimin Liu
    Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Nature 467:420-5. 2010
    ..falciparum formed a monophyletic lineage within the gorilla parasite radiation. These findings indicate that P. falciparum is of gorilla origin and not of chimpanzee, bonobo or ancient human origin...
  2. ncbi Hybrid origin of SIV in chimpanzees
    Elizabeth Bailes
    University of Nottingham, Nottingham NG72UH, UK
    Science 300:1713. 2003
  3. pmc Frequent simian foamy virus infection in persons occupationally exposed to nonhuman primates
    William M Switzer
    HIV and Retrovirology Branch, Division of AIDS, STD, and TB Laboratory Research, National Center for HIV, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Virol 78:2780-9. 2004
    ..Our data highlight the importance of studies to better define the public health implications of zoonotic SFV infections...
  4. pmc Molecular ecology and natural history of simian foamy virus infection in wild-living chimpanzees
    Weimin Liu
    Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
    PLoS Pathog 4:e1000097. 2008
    ....
  5. pmc Diverse contexts of zoonotic transmission of simian foamy viruses in Asia
    Lisa Jones-Engel
    Division of International Programs, National Primate Research Center, University of Washington, Seattle, Washington 98195, USA
    Emerg Infect Dis 14:1200-8. 2008
    ..Thus, SFV infections are likely to be prevalent among persons who live or work near nonhuman primates in Asia...
  6. ncbi Screening for simian foamy virus infection by using a combined antigen Western blot assay: evidence for a wide distribution among Old World primates and identification of four new divergent viruses
    Althaf I Hussain
    HIV and Retrovirology Branch, Division of AIDS, STD, and TB Laboratory Research, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Virology 309:248-57. 2003
    ..These results demonstrate the ability of the CA-WB assay to detect infection in a large number of NHP species, including previously uncharacterized infections with divergent SFVs...
  7. ncbi Catastrophic ape decline in western equatorial Africa
    Peter D Walsh
    Department of Ecology and Evolutionary Biology, Guyot Hall, Princeton, New Jersey 08540, USA
    Nature 422:611-4. 2003
    ..Without aggressive investments in law enforcement, protected area management and Ebola prevention, the next decade will see our closest relatives pushed to the brink of extinction...
  8. ncbi Descriptive epidemiology of fatal respiratory outbreaks and detection of a human-related metapneumovirus in wild chimpanzees (Pan troglodytes) at Mahale Mountains National Park, Western Tanzania
    Taranjit Kaur
    Department of Biomedical Sciences and Pathobiology, Virginia Maryland Regional College of Veterinary Medicine, Virginia Tech, Blacksburg, Virginia 24061, USA
    Am J Primatol 70:755-65. 2008
    ..In addition, descriptive epidemiology should be a major component of disease outbreak investigations...
  9. ncbi SIVcpz in wild chimpanzees
    Mario L Santiago
    University of Alabama at Birmingham, Birmingham, AL 35294 6024, USA
    Science 295:465. 2002
  10. pmc Wild chimpanzees infected with 5 Plasmodium species
    Marco Kaiser
    Robert Koch Institute, Berlin, Germany
    Emerg Infect Dis 16:1956-9. 2010
    ..We surveyed Plasmodium spp. diversity in wild chimpanzees living in an undisturbed tropical rainforest habitat and found 5 species: P. malariae, P. vivax, P. ovale, P. reichenowi, and P. gaboni...
  11. ncbi Multiple Ebola virus transmission events and rapid decline of central African wildlife
    Eric M Leroy
    Institut de Recherche pour le Developpement, UR034, Centre International de Recherches Medicales de Franceville, BP 769 Franceville, Gabon
    Science 303:387-90. 2004
    ..Surveillance of animal mortality may help to predict and prevent human Ebola outbreaks...
  12. ncbi Natural simian foamy virus infection in wild-caught gorillas, mandrills and drills from Cameroon and Gabon
    Sara Calattini
    Unité d Epidémiologie et Physiopathologie des Virus Oncogènes, Département EMMI, Institut Pasteur, Paris, France
    J Gen Virol 85:3313-7. 2004
    ....
  13. ncbi Noninvasive monitoring of respiratory viruses in wild chimpanzees
    Sophie Köndgen
    Robert Koch Institut, Berlin, Germany
    Ecohealth 7:332-41. 2010
    ..The methods presented here may also be applied for the investigation of further acute diseases in great apes and other species...
  14. pmc Identification of Plasmodium malariae, a human malaria parasite, in imported chimpanzees
    Toshiyuki Hayakawa
    Laboratory of Malariology, International Research Center of Infectious Diseases, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan
    PLoS ONE 4:e7412. 2009
    ..malariae infection in humans. To our knowledge, this is the first to report P. malariae infection in chimpanzees and a human malaria parasite from nonhuman primates imported to a nonendemic country...
  15. pmc Chimpanzee malaria parasites related to Plasmodium ovale in Africa
    Linda Duval
    Laboratoire de Biologie fonctionnelle des protozoaires, USM 504, Museum national d histoire naturelle, Paris, France
    PLoS ONE 4:e5520. 2009
    ..ovale strains isolated from humans. This study provides the first evidence of possibility of natural cross-species exchange of P. ovale between humans and chimpanzees of the subspecies Pan t. troglodytes...
  16. ncbi Lethal pneumonia in a captive juvenile chimpanzee (Pan troglodytes) due to human-transmitted human respiratory syncytial virus (HRSV) and infection with Streptococcus pneumoniae
    Claudia A Szentiks
    Leibniz Institute for Zoo and Wildlife Research, Berlin, Germany
    J Med Primatol 38:236-40. 2009
    ..One infant female chimpanzee with severe respiratory symptoms died despite immediate medical treatment and was submitted for necropsy...
  17. ncbi Pandemic human viruses cause decline of endangered great apes
    Sophie Köndgen
    Robert Koch Institut, Nordufer 20, D 13353 Berlin, Germany
    Curr Biol 18:260-4. 2008
    ..These observations illustrate the challenge of maximizing the benefit of research and tourism to great apes while minimizing the negative side effects...
  18. ncbi Molecular epidemiology of simian T-lymphotropic virus (STLV) in wild-caught monkeys and apes from Cameroon: a new STLV-1, related to human T-lymphotropic virus subtype F, in a Cercocebus agilis
    E Nerrienet
    Centre Pasteur du Cameroun, BP 1274, , Cameroon
    J Gen Virol 82:2973-7. 2001
    ....
  19. ncbi Ebola virus outbreak among wild chimpanzees living in a rain forest of Côte d'Ivoire
    P Formenty
    World Health Organization WHO Taï Forest Project, and Centre Suisse de recherches scientifiques, Abidjan, Cote d Ivoire
    J Infect Dis 179:S120-6. 1999
    ..A high mortality rate among apes tends to indicate that they are not the reservoir for the disease causing the illness. These points will have to be investigated by additional studies...
  20. ncbi Detection and molecular characterization of foamy viruses in Central African chimpanzees of the Pan troglodytes troglodytes and Pan troglodytes vellerosus subspecies
    Sara Calattini
    Unité d Epidémiologie et Physiopathologie des Virus Oncogènes, Département EEMI, Institut Pasteur, Paris, France
    J Med Primatol 35:59-66. 2006
    ..This zoonotic infection was demonstrated mainly after bites by chimpanzees [Pan troglodytes (P. t.)] of the West African P. t. verus subspecies in primatology centers or zoos in the USA...
  21. pmc Transmission of human and macaque Plasmodium spp. to ex-captive orangutans in Kalimantan, Indonesia
    Michael J C Reid
    Simon Fraser University, Burnaby, British Columbia, Canada
    Emerg Infect Dis 12:1902-8. 2006
    ..These data have potential implications for the conservation of orangutans and also for the bidirectional transmission of parasites between orangutans and humans visiting or living in the region...
  22. pmc Characterization of Bacillus anthracis-like bacteria isolated from wild great apes from Cote d'Ivoire and Cameroon
    Silke R Klee
    Robert Koch Institut, Centre for Biological Safety 2, Nordufer 20, 13353 Berlin, Germany
    J Bacteriol 188:5333-44. 2006
    ..We propose that the newly discovered atypical B. anthracis strains share a common ancestor with classic B. anthracis or that they emerged recently by transfer of the B. anthracis plasmids to a strain of the B. cereus group...
  23. ncbi The epidemiology of simian immunodeficiency virus infection in a large number of wild- and captive-born chimpanzees: evidence for a recent introduction following chimpanzee divergence
    William M Switzer
    HIV and Retrovirology Branch, Division of HIV AIDS Prevention, National Center for HIV, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    AIDS Res Hum Retroviruses 21:335-42. 2005
    ..The absence of SIVcpz infection in P. t. verus suggests that SIVcpz may not be endemic to this subspecies and implies that SIVcpz may have been introduced more recently into the chimpanzee subspecies following divergence...
  24. ncbi Non-invasive body temperature measurement of wild chimpanzees using fecal temperature decline
    Siv Aina Jensen
    Max Planck Institute for Evolutionary Anthropology, Leipzig 04103, Germany
    J Wildl Dis 45:542-6. 2009
    ..The method was successfully applied and the average estimated temperature of the chimpanzees was 37.2 C. This simple-to-use field method reliably estimates the body temperature of wild chimpanzees and probably also other large mammals...
  25. pmc Orangutans not infected with Plasmodium vivax or P. cynomolgi, Indonesia
    Balbir Singh
    Malaria Research Centre, Universiti Malaysia Sarawak, Sarawak, Malaysia
    Emerg Infect Dis 15:1657-8. 2009
    ..We found that these orangutans are not hosts of P. cynomolgi and P. vivax. Analysis of >or=1 genes is needed to identify Plasmodium spp. infecting orangutans...
  26. pmc Anthrax, but not Bacillus anthracis?
    Richard Okinaka
    Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America
    PLoS Pathog 2:e122. 2006
  27. ncbi Anthrax in Western and Central African great apes
    Fabian H Leendertz
    Great Ape Health Monitoring Unit, c o Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
    Am J Primatol 68:928-33. 2006
    ....
  28. pmc Simian T-cell leukemia virus (STLV) infection in wild primate populations in Cameroon: evidence for dual STLV type 1 and type 3 infection in agile mangabeys (Cercocebus agilis)
    Valerie Courgnaud
    UR36, IRD, and University of Montpellier I, Montpellier, France
    J Virol 78:4700-9. 2004
    ....
  29. ncbi Fruit bats as reservoirs of Ebola virus
    Eric M Leroy
    Centre International de Recherches Medicales de Franceville, BP 769 Franceville, Gabon
    Nature 438:575-6. 2005
    ..We find evidence of asymptomatic infection by Ebola virus in three species of fruit bat, indicating that these animals may be acting as a reservoir for this deadly virus...
  30. ncbi Non-invasive testing reveals a high prevalence of simian T-lymphotropic virus type 1 antibodies in wild adult chimpanzees of the Taï National Park, Côte d'Ivoire
    Fabian H Leendertz
    Zentrum für Biologische Sicherheit, Robert Koch Institut, Nordufer 20, 13353 Berlin, Germany
    J Gen Virol 85:3305-12. 2004
    ..The prevalence of STLV-1 antibodies in adults and adolescents was significantly higher (35/49, 71.4 %) than that in infant and juvenile chimpanzees (3/31, 9.7 %)...
  31. ncbi Climate-based health monitoring systems for eco-climatic conditions associated with infectious diseases
    E Pinzon
    Science Systems and Applications, Inc SSAI, USA
    Bull Soc Pathol Exot 98:239-43. 2005
    ..This article provides a condensed, and selective look at classical material and recent research about remote sensing and GIS (geographic information system) applications in public health...
  32. ncbi A serological survey of Ebola virus infection in central African nonhuman primates
    E M Leroy
    Centre International de Recherches Medicales de Franceville, Institut de Recherche pour le Developpement, UR034, Franceville, Gabon
    J Infect Dis 190:1895-9. 2004
    ..They also suggest that future Ebola outbreaks may occur anywhere in the central African forest region...
  33. ncbi The potential significance of adaptive evolution and dimerization in chimpanzee intercellular cell adhesion molecules (ICAMs)
    Nicole A R Walter
    Evolutionary Genomics, Colorado Bioscience Park Center, 12635 East Montview Boulevard, Aurora, Colorado 80010, USA
    J Theor Biol 232:339-46. 2005
    ....
  34. ncbi Contrasting histories of G6PD molecular evolution and malarial resistance in humans and chimpanzees
    Brian C Verrelli
    Center for Evolutionary Functional Genomics, The Biodesign Institute, Tempe, Arizona, USA
    Mol Biol Evol 23:1592-601. 2006
    ..These comparative analyses suggest that the recent signature of positive selection at G6PD in humans is unique...
  35. pmc Novel polyomavirus detected in the feces of a chimpanzee by nested broad-spectrum PCR
    Reimar Johne
    Institute for Virology, Faculty of Veterinary Medicine, University of Leipzig, An den Tierkliniken 29, D 04103 Leipzig, Germany
    J Virol 79:3883-7. 2005
    ....
  36. ncbi Molecular evidence for the infection of zoo chimpanzees by pig Ascaris
    Peter Nejsum
    Danish Centre for Experimental Parasitology, The Royal Veterinary and Agricultural University, Dyrlaegevej 100, DK 1870, Frederiksberg C, Copenhagen, Denmark
    Vet Parasitol 139:203-10. 2006
    ..Pigs as a potential source of Ascaris infections for both captive and wild chimpanzees and other animals, therefore needs to be considered and appropriate steps taken to prevent such infection...
  37. ncbi Ebola and great apes in Central Africa: current status and future needs
    W Karesh
    Field Veterinary Program Wildlife Conservation Society, 2300 Southern Blvd, Bronx, NY 10460, USA
    Bull Soc Pathol Exot 98:237-8. 2005
  38. ncbi Posaconazole therapy for systemic coccidioidomycosis in a chimpanzee (Pan troglodytes): a case report
    Kimberly Vinette Herrin
    Mycoses 48:447-52. 2005
    ..immitis serum antibody titre was noted. The successful suppression of coccidioidomycosis observed in this chimpanzee suggests that posaconazole may have a role in the treatment of CNS infections caused by susceptible fungi...
  39. pmc Evolutionary relationships of "Candidatus Riesia spp.," endosymbiotic enterobacteriaceae living within hematophagous primate lice
    Julie M Allen
    Zoology Department, Florida Museum of Natural History, University of Florida, Dickinson Hall, Gainesville, FL 32611, USA
    Appl Environ Microbiol 73:1659-64. 2007
    ..Given the evidence for cospeciation with primate lice and the evidence for fast evolutionary rates, this lineage of endosymbiotic bacteria can be evaluated as a fast-evolving marker of both louse and primate evolutionary histories...
  40. ncbi Sharing malarias
    N J White
    Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand
    Lancet 363:1006. 2004
  41. ncbi Clinical and pathologic manifestation of oesophagostomosis in African great apes: does self-medication in wild apes influence disease progression?
    Sabrina Krief
    USM 104 Eco anthropologie et Ethnobiologie, Département Hommes, Natures, sociétés, Museum national d histoire naturelle, Paris, France
    J Med Primatol 37:188-95. 2008
    ....
  42. pmc Hepatitis C virus JFH-1 strain infection in chimpanzees is associated with low pathogenicity and emergence of an adaptive mutation
    Takanobu Kato
    Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA
    Hepatology 48:732-40. 2008
    ..A common mutation G838R in the NS2 region emerged early in both chimpanzees. This mutation enhances viral assembly, leading to an increase in viral production in transfected or infected cells...
  43. ncbi Specific nature of cellular immune responses elicited by chimpanzees against HIV-1
    Sunita S Balla-Jhagjhoorsingh
    Department of Virology, Biomedical Primate Research Centre, Rijswijk, The Netherlands
    Hum Immunol 64:681-8. 2003
    ..Here we review the characteristics of the HIV-1-specific cell-mediated immune responses mounted by chimpanzees, and we postulate the mechanisms that have evolved that facilitate their resistance to acquired immunodeficiency syndrome...
  44. pmc Hepatitis C virus p7 protein is crucial for assembly and release of infectious virions
    Eike Steinmann
    Department of Molecular Virology, University of Heidelberg, Heidelberg, Germany
    PLoS Pathog 3:e103. 2007
    ....
  45. ncbi Characterization of a new simian T-lymphocyte virus type 1 (STLV-1) in a wild living chimpanzee (Pan troglodytes verus) from Ivory Coast: evidence of a new STLV-1 group?
    Fabian H Leendertz
    Retrovirology, Robert Koch Institut, Berlin, Germany
    AIDS Res Hum Retroviruses 19:255-8. 2003
    ..The tax sequences reveal two sequence differences that seem to be unique as they are not found in any of the HTLV-1 or STLV-1 tax sequences from the public databases...
  46. pmc Chimpanzee reservoirs of pandemic and nonpandemic HIV-1
    Brandon F Keele
    Departments of Medicine and Microbiology, University of Alabama at Birmingham, Birmingham, AL, USA
    Science 313:523-6. 2006
    ..These findings establish P. t. troglodytes as a natural reservoir of HIV-1...
  47. ncbi Nevus lipomatosus cutaneus superficialis (Hoffmann-Zurhelle) in a chimpanzee (Pan troglodytes)
    Robert Klopfleisch
    Friedrich Loeffler Institut, Federal Research Institute for Animal Health, Greifswald Insel Riems, Germany
    J Med Primatol 36:57-60. 2007
    ..After surgical removal, the mass recurred and extended progressively over a period of 5 years...
  48. ncbi Conservation biology. Ebola, hunting push ape populations to the brink
    Jocelyn Kaiser
    Science 300:232. 2003
  49. ncbi Potential for Ebola transmission between gorilla and chimpanzee social groups
    Peter D Walsh
    Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, 04103 Leipzig, Germany
    Am Nat 169:684-9. 2007
    ..These observations support a reassessment of ape-to-ape transmission as an amplifier of Ebola outbreaks...
  50. ncbi Reduced transmission and prevalence of simian T-cell lymphotropic virus in a closed breeding colony of chimpanzees (Pan troglodytes verus)
    H Niphuis
    Department of Virology, Biomedical Primate Research Centre, Lange Kleiweg 139, 2288 GJ Rijswijk, The Netherlands
    J Gen Virol 84:615-20. 2003
    ..In contrast, transmission from infected mother to child was not observed, suggesting that this is not a common route of transmission for STLV in this species, which is in contrast to HTLV-1 in humans...
  51. ncbi Epidemiology. Ebola outbreaks may have had independent sources
    Gretchen Vogel
    Science 303:298-9. 2004
  52. ncbi Cholesterol values in free-ranging gorillas (Gorilla gorilla gorilla and Gorilla beringei) and Bornean orangutans (Pongo pygmaeus)
    Debra A Schmidt
    Lincoln Park Zoo, Chicago, Illinois 60614, USA
    J Zoo Wildl Med 37:292-300. 2006
    ..The higher total cholesterol and low-density lipoprotein cholesterol concentrations in captive apes may predispose them to cardiovascular disease and might be attributed to diets, limited energy expenditure, and genetics...
  53. pmc Wild animal mortality monitoring and human Ebola outbreaks, Gabon and Republic of Congo, 2001-2003
    Pierre Rouquet
    Centre International de Recherches Medicales de Franceville, CIRMF BP 769, Franceville, Gabon
    Emerg Infect Dis 11:283-90. 2005
    ..Wild animal outbreaks began before each of the 5 human Ebola outbreaks. Twice we alerted the health authorities to an imminent risk for human outbreaks, weeks before they occurred...
  54. ncbi A new entodiniomorphid ciliate, Troglocorys cava n. g., n. sp., from the wild eastern chimpanzee (Pan troglodytes schweinfurthii) from Uganda
    Toshihiro Tokiwa
    Department of Parasitology, Nippon Veterinary and Life Science University, Musashino, Tokyo 180 8602, Japan
    J Eukaryot Microbiol 57:115-20. 2010
    ....
  55. ncbi Reactivation of lymphocryptovirus (Epstein-Barr virus chimpanzee) and dominance in chimpanzees
    Rain Yamamoto
    Department of Biological Sciences, Graduate School of Science, University of Tokyo, Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    J Gen Virol 91:2049-53. 2010
    ..001). The effect of the male dominance rank did not differ between the pre-Form and post-Form periods (t=-1.557, P=0.12). Reactivation of LCV (EBV) as an immunological stress marker for humans might also be applied to chimpanzees...
  56. ncbi Debilitating clinical disease in a wild-born captive western lowland gorilla (Gorilla gorilla gorilla) co-infected with varicella zoster virus (VZV) and simian T-lymphotropic virus (STLV)
    Nicholas Masters
    International Zoo Veterinary Group, Keighley Business Centre, South Street, Keighley, West Yorkshire, BD21 1AG, United Kingdom
    J Zoo Wildl Med 41:713-6. 2010
    ..It is hypothesized that recrudescence of VZV and other disease processes described were associated with chronic STLV infection and the end of a characteristically long incubation period...
  57. pmc Monitoring of hepatitis C virus quasispecies in chronic infection by matrix-assisted laser desorption ionization-time of flight mass spectrometry mutation detection
    Carmen Yea
    Metabolism Research Program, The Hospital for Sick Children, Toronto, Canada
    J Clin Microbiol 45:1053-7. 2007
    ..We also used the mass spectrometry method in the clinical follow-up of a chronically infected patient over a 5-year period...
  58. ncbi Acute appendicitis in a chimpanzee (Pan troglodytes)
    Jennifer D'Agostino
    College of Veterinary Medicine, The Veterinary Medical Teaching Hospital, Kansas State University, Manhattan, KS, USA
    J Med Primatol 36:119-23. 2007
    ..An irregular, mineral opacity was identified in the caudal right quadrant of the abdomen on radiographs and computed tomography scan, which appeared to be in the region of the cecal appendage...
  59. pmc Identification of a hepatitis B virus genome in wild chimpanzees (Pan troglodytes schweinfurthi) from East Africa indicates a wide geographical dispersion among equatorial African primates
    Jean Pierre Vartanian
    Unite de Retrovirologie Moleculaire, Institut Pasteur, Paris, France
    J Virol 76:11155-8. 2002
    ..An entire hepatitis B virus (HBV) genome was amplified and sequenced from samples taken from one animal. This indicates that HBV is distributed across the entire range of chimpanzee habitats...
  60. ncbi Leucoencephalopathy with cerebral calcinosis in a young chimpanzee (Pan troglodytes) - a case report
    M Zoller
    Department of Infectious Pathology, German Primate Center, Gottingen, Germany
    J Med Primatol 36:385-90. 2007
    ..A 4-year-old chimpanzee (Pan troglodytes) had a clinical history of a 2-year progressive central nervous dysfunction including convulsions and severe paralysis...
  61. ncbi Presence and species identification of the gapeworm Mammomonogamus laryngeus (Railliet, 1899) (Syngamidae: Nematoda) in a semi-wild population of Sumatran orangutan (Pongo abelii) in Indonesia
    I Foitova
    Institute of Botany and Zoology, Masaryk University, Kotlarska 2, 61137, Brno, Czech Republic
    Res Vet Sci 84:232-6. 2008
    ..Coprological monitoring of infection in rehabilitants in this area as well as among the wild population of orangutan is necessary...
  62. ncbi CD4+ immune escape and subsequent T-cell failure following chimpanzee immunization against hepatitis C virus
    Montserrat Puig
    Laboratory of Hepatitis Viruses, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    Hepatology 44:736-45. 2006
    ..Vaccines that can induce strong T-cell responses prior to challenge will not necessarily prevent persistent HCV infection...
  63. ncbi Morphological variability within Oesophagostomum bifurcum among different primate species from Ghana
    J M de Gruijter
    Department of Parasitology, Leiden University Medical Centre, University of Leiden, PO Box 9600, 2300 RC Leiden, The Netherlands
    J Helminthol 80:357-61. 2006
    ..These findings suggest that O. bifurcum from different species of primate host represent distinct population variants, also supported by recent epidemiological and genetic studies of O. bifurcum from such hosts...
  64. ncbi Using retrospective health data from the Gombe chimpanzee study to inform future monitoring efforts
    E V Lonsdorf
    Center for the Study and Conservation of Apes, Department of Conservation and Science, Lincoln Park Zoo, Chicago, Illinois 60614, USA
    Am J Primatol 68:897-908. 2006
    ..Here we present the types of data found during the survey, discuss the usefulness of these data in the context of risk assessment, and describe how our current monitoring effort at Gombe was designed based on our findings...
  65. ncbi Intestinal parasite infections and fecal steroid levels in wild chimpanzees
    Michael P Muehlenbein
    Department of Anthropology, University of Wisconsin Milwaukee, Milwaukee, Wisconsin 53211, USA
    Am J Phys Anthropol 130:546-50. 2006
    ..The utility of fecal samples for assessing immune-endocrine interactions is discussed...
  66. ncbi Sequence analysis of a highly divergent HIV-1-related lentivirus isolated from a wild captured chimpanzee
    M M Vanden Haesevelde
    Innogenetics N V, Industriepark 7, Gent, Belgium
    Virology 221:346-50. 1996
    ..Our data suggest multiple introductions of HIV-1 in the human population and shed new light on the origin of the HIV-1 pandemic...
  67. ncbi Linear enamel hypoplasia in the great apes: analysis by genus and locality
    Darcy Lee Hannibal
    Department of Anthropology, University of Oregon, Eugene, Oregon 97403, USA
    Am J Phys Anthropol 127:13-25. 2005
    ..It is likely that both biological and environmental factors influence the high frequencies of enamel hypoplasia exhibited in the great apes...
  68. ncbi Hepatitis C virus kinetics and host responses associated with disease and outcome of infection in chimpanzees
    Marian E Major
    Laboratory of Hepatitis Viruses, Division of Viral Products Center for Biologics Evaluation and Research Food and Drug Administration, Bethesda, MD, USA
    Hepatology 39:1709-20. 2004
    ..However, the pathogenesis of HCV may be determined by a more rapid onset of the induced response and the cell population that migrates to the liver...
  69. ncbi CpG DNA overcomes hyporesponsiveness to hepatitis B vaccine in orangutans
    H L Davis
    Loeb Health Research Institute at the Ottawa Hospital, 725 Parkdale Avenue, Ottawa, Canada
    Vaccine 18:1920-4. 2000
    ..This is the first demonstration of CpG DNA in a great ape and the results have important implications for the vaccination of humans against HBV and other diseases...
  70. ncbi A single genotype of Encephalitozoon intestinalis infects free-ranging gorillas and people sharing their habitats in Uganda
    Thaddeus K Graczyk
    The W Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
    Parasitol Res 88:926-31. 2002
    ..intestinalis. It is highly unlikely that these two identical Enc. intestinalis genotypes were acquired independently by gorillas and people; it is much more probable that one group initiated infection of the other...
  71. ncbi Endoparasites of western lowland gorillas (Gorilla gorilla gorilla) at Bai Hokou, Central African Republic
    Andrea S Freeman
    Field Veterinary Program, Wildlife Conservation Society, 185th Street and Southern Boulevard, Bronx, New York 10460, USA
    J Wildl Dis 40:775-81. 2004
    ..With the advent of ecotourism in this study area, continued monitoring is indicated for insuring the health of both gorillas and humans in the Bai Hokou study area...
  72. ncbi Cataract surgery with foldable intraocular lens implants in captive lowland gorillas (Gorilla gorilla gorilla)
    J T H N de Faber
    Rotterdam Eye Hospital, 3011 BH Rotterdam, The Netherlands
    J Zoo Wildl Med 35:520-4. 2004
    ..This animal developed bilateral after-cataract and therefore needed a second intervention in both eyes using Nd:YAG laser treatment. The genetic component of juvenile cataracts should be considered in breeding management programs...
  73. ncbi Intestinal parasites found in the research group of mountain gorillas in Bwindi Impenetrable National Park, Uganda: preliminary results
    Jessica M Rothman
    Cornell University, Ithaca New York 14853, USA
    Ann N Y Acad Sci 969:346-9. 2002
    ..An increasing threat to this group of gorillas is the presence of local field assistants and researchers. We found no evidence of human parasites in the fecal samples from this gorilla group...
  74. ncbi Simian T cell leukaemia virus type I subtype B in a wild-caught gorilla (Gorilla gorilla gorilla) and chimpanzee (Pan troglodytes vellerosus) from Cameroon
    Eric Nerrienet
    Laboratoire de Virologie, Centre Pasteur du Cameroun, , Cameroon
    J Gen Virol 85:25-9. 2004
    ..Such findings reinforce the hypothesis of interspecies transmission of STLV-I to humans, leading to the present day distribution of HTLV-I in central African inhabitants...
  75. ncbi Effects of repeated anthelmintic treatment on Enterobius vermicularis infection in chimpanzees
    Tadao Nakano
    Department of Infectious Diseases, Faculty of Medicine, Oita University, Hasama, Oita 879 5593, Japan
    J Parasitol 91:679-82. 2005
    ..Complete eradication was not achieved, however, presumably because of reinfection. The female proportion among discharged worms tended to increase as the treatment was repeated...
  76. ncbi Chronic hepatitis C virus infection established and maintained in chimpanzees independent of dendritic cell impairment
    Christine Rollier
    Department of Virology, Biomedical Primate Research Centre, 2280 GH Rijswijk, The Netherlands
    Hepatology 38:851-8. 2003
    ..Indeed, the maturation and allostimulatory impairment, as described in patient studies, are not necessary prerequisites but rather possible consequences of persistent and active HCV infection associated with disease progression...
  77. pmc Neoplasia in the chimpanzee (Pan spp.)
    S L Brown
    Southwest National Primate Research Center at the Southwest Foundation for Biomedical Research, San Antonio, TX 78245 0549, USA
    J Med Primatol 38:137-44. 2009
    ..There is minimal information concerning cancer in the chimpanzee and such information would be valuable to individuals caring for and using them for research...
  78. ncbi Environmental management procedures following fatal melioidosis in a captive chimpanzee (Pan troglodytes)
    Angkana Sommanustweechai
    Bureau of Research, Conservation and Education, Zoological Park Organization, Bangkok 10300, Thailand
    J Zoo Wildl Med 44:475-9. 2013
    ..pseudomallei. Following the soil treatment in the exhibit, all chimpanzees have remained free of clinical signs consistent with melioidosis...
  79. ncbi Scheuermann kyphosis in nonhuman primates
    Brian M Farrell
    St Mary s Medical Center, San Francisco, CA 94117, USA
    Spine (Phila Pa 1976) 37:E1432-7. 2012
    ..A cadaveric survey of the thoracic spines of extant species of nonbipedal primates for the presence of Scheuermann kyphosis...
  80. ncbi Clinical management of a western lowland gorilla (Gorilla gorilla gorilla) with a cardiac resynchronization therapy device
    Elizabeth Marie Rush
    Birmingham Zoo, Inc, 2630 Cahaba Road, Birmingham, Alabama 35223, USA
    J Zoo Wildl Med 42:263-76. 2011
    ..This describes the comprehensive medical, husbandry, and training techniques necessary to successfully manage this intense clinical case in conjunction with intracardiac device therapy...
  81. pmc Origins of HIV and the AIDS pandemic
    Paul M Sharp
    Institute of Evolutionary Biology and Centre for Immunity, Infection and Evolution, University of Edinburgh, Edinburgh EH9 3JT, United Kingdom
    Cold Spring Harb Perspect Med 1:a006841. 2011
    ..Tracing the genetic changes that occurred as SIVs crossed from monkeys to apes and from apes to humans provides a new framework to examine the requirements of successful host switches and to gauge future zoonotic risk...
  82. ncbi African Plasmodium vivax: distribution and origins
    Richard Culleton
    Malaria Unit, Institute of Tropical Medicine NEKKEN, Nagasaki University, Nagasaki, Japan
    Int J Parasitol 42:1091-7. 2012
    ..vivax as a human parasite. With the support of new evidence from mitochondrial genome sequencing, we propose that the evidence is consistent with current, extant P. vivax populations having their origins in Africa...
  83. pmc Probable transmission of coxsackie B3 virus from human to chimpanzee, Denmark
    Sandra C Abel Nielsen
    University of Copenhagen, Copenhagen, Denmark
    Emerg Infect Dis 18:1163-5. 2012
    ..Identification of coxsackie B3 virus, a common human pathogen, as the causative agent, and its severe manifestation, raise questions about pathogenicity and transmissibility among humans and other primates...
  84. ncbi Identification and molecular characterization of new STLV-1 and STLV-3 strains in wild-caught nonhuman primates in Cameroon
    Florian Liegeois
    UMR 145, Institut de Recherche pour le Developpement IRD and University of Montpellier 1, Montpellier, France
    Virology 371:405-17. 2008
    ..cephus. Finally, we identify relative divergence levels in the tax/rex phylogeny suggesting that additional types of PTLV should be defined, particularly for the highly divergent STLV-1(MarB43) strain that we provisionally name STLV-5...
  85. ncbi Validation of multiple diagnostic techniques to detect Cryptosporidium sp. and Giardia sp. in free-ranging western lowland gorillas (Gorilla gorilla gorilla) and observations on the prevalence of these protozoan infections in two populations in Gabon
    Martine van Zijll Langhout
    Mikongo Conservation Centre, Lope National Park, Gabon
    J Zoo Wildl Med 41:210-7. 2010
    ..and Giardia sp. infections in free-ranging western lowland gorillas and highlights the importance of verifying the accuracy of diagnostic techniques developed for human use before applying these to non-human primates...
  86. ncbi Scoliosis in an Orangutan
    Satyajit B Naique
    Imperial College School of Medicine, Charing Cross Hospital, London, United Kingdom
    Spine (Phila Pa 1976) 28:E143-5. 2003
    ..The first case of scoliosis in an Orangutan spine is reported...
  87. ncbi Tetraparesis resembling acute transverse myelitis in a captive chimpanzee (Pan troglodytes): long-term care and recovery
    T Miyabe-Nishiwaki
    Center for Human Evolution Modeling Research, Primate Research Institute, Kyoto University, Inuyama, Aichi, Japan
    J Med Primatol 39:336-46. 2010
    ..Magnetic resonance imaging showed a diffuse T2-weighted hyperintensive lesion, indicating inflammation at the C1-2 level. All infective, autoimmune, and vascular investigations were unremarkable...
  88. ncbi Causes of death in the Kasekela chimpanzees of Gombe National Park, Tanzania
    J M Williams
    The Jane Goodall Institute s Center for Primate Studies, Department of Ecology, Evolution and Behavior, University of Minnesota, St Paul, Minnesota, USA
    Am J Primatol 70:766-77. 2008
    ..Intercommunity lethal aggression involving the Kasekela community was observed most frequently during two periods. Other less common causes of death included injury, loss of mother, maternal disability, and poaching...
  89. ncbi Successful transabdominal subxiphoid pericardiostomy to relieve chronic pericardial effusion in a Sumatran orangutan (Pongo abelli)
    P K Robbins
    Veterinary Services, San Diego Zoo, 1354 Old Globe Way, San Diego, California 92101, USA
    J Zoo Wildl Med 40:564-7. 2009
    ..Transabdominal subxiphoid pericardiostomy offers a straightforward surgical approach that can provide significant relief in cases of chronic pericardial effusion in great apes...
  90. ncbi Medical and surgical management of reproductive neoplasia in two western lowland gorillas (Gorilla gorilla gorilla)
    Elizabeth M Stringer
    North Carolina State University, College of Veterinary Medicine, Raleigh, NC 27606, USA
    J Med Primatol 39:328-35. 2010
    ..Reports of female reproductive tract neoplasia are infrequent in great apes...
  91. pmc A genetic variant of hepatitis B virus divergent from known human and ape genotypes isolated from a Japanese patient and provisionally assigned to new genotype J
    Kanako Tatematsu
    Department of Clinical Molecular Informative Medicine, Nagoya, City University Graduate School of Medical Sciences, Mizuho, Nagoya, Japan
    J Virol 83:10538-47. 2009
    ..Since HBV/J is positioned phylogenetically in between human and ape genotypes, it may help to trace the origin of HBV and merits further epidemiological surveys...
  92. pmc Isolation and phylogenetic characterization of Ebola viruses causing different outbreaks in Gabon
    M C Georges Courbot
    , Franceville, Gabon
    Emerg Infect Dis 3:59-62. 1997
    ..As in earlier Ebola virus outbreaks, no genetic variability was detected between virus samples taken during an individual outbreak...
  93. pmc Evaluation of accumulation of hepatitis C virus mutations in a chronically infected chimpanzee: comparison of the core, E1, HVR1, and NS5b regions
    L Lu
    Hepatitis Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Virol 75:3004-9. 2001
    ..In the core and E1 regions, synonymous substitutions predominated and gradually increased over time. However, within the HVR1 region, nonsynonymous substitutions predominated but gradually decreased over time...
  94. ncbi Management of hepatitis B virus infections in two gibbons and a western lowland gorilla in a zoological collection
    S M Thornton
    Veterinary Science Unit, Institute of Zoology, Zoological Society of London
    Vet Rec 149:113-5. 2001
    ....
  95. ncbi Longitudinal comparison of virus load parameters and CD8 T-cell suppressive capacity in two SIVcpz-infected chimpanzees
    P Ondoa
    Institute of Tropical Medicine, Antwerp, Belgium
    J Med Primatol 30:243-53. 2001
    ....
  96. ncbi [The origin and evolution of HIV]
    Jun Takehisa
    Department of Medicine, University of Alabama at Birmingham, USA
    Nihon Rinsho 68:410-4. 2010
    ..Second, in vitro studies demonstrate that SIVcpz and SIVgor have many of the biological properties necessary for establishing a persistent infection in humans...
  97. ncbi Uterine adenomyosis in an orang-utan (Pongo abelii/pygmaeus)
    K J Graham
    North Shore Veterinary Specialist Centre, Crows Nest, New South Wales 2065, Australia
    Aust Vet J 87:66-9. 2009
    ....
  98. ncbi Chimpanzees in hepatitis C virus research: 1998-2007
    R H Bettauer
    Bettauer BioMed Research, Mc Lean, VA, USA
    J Med Primatol 39:9-23. 2010
    ..Chimpanzees have been widely used in hepatitis C virus (HCV) research, but their endangered status and high financial and ethical costs have prompted a closer review...
  99. ncbi Conservation biology. Can great apes be saved from Ebola?
    Gretchen Vogel
    Science 300:1645. 2003
  100. pmc Isolates of Zaire ebolavirus from wild apes reveal genetic lineage and recombinants
    Tatiana J Wittmann
    Centre International de Recherches Medicales de Franceville, BP 769 Franceville, Gabon
    Proc Natl Acad Sci U S A 104:17123-7. 2007
    ..The potential for recombination adds an additional level of complexity to unraveling and potentially controlling the emergence of ZEBOV in humans and wildlife species...
  101. ncbi Dientamoeba fragilis: initial evidence of pathogenicity in the western lowland gorilla (Gorilla gorilla gorilla)
    Felix Lankester
    Limbe Wildlife Centre, Limbe Botanic Garden Street, Limbe, South West Region, Cameroon
    J Zoo Wildl Med 41:350-2. 2010
    ..The report suggests that metronidazole was effective because it eliminated the protozoa, Dientamoeba fragilis. Dientamoeba fragilis should be considered on the differential diagnosis list of any captive gorilla with IBS-like symptoms...

Research Grants3

  1. PROPHYLACTIC & THERPEUTIC DNA IMMUNIZATION AGAINST HCV
    Alfred Prince; Fiscal Year: 2003
    ..The immunogenicity of HCV genes presented as fusion proteins with ubiquitin and secreting and non-secreting HCV gene-containing plasmids will be compared. ..
  2. Calorie Restriction Effects on Chromosomal Aberrations
    CHARLEEN MOORE; Fiscal Year: 2003
    ..The results will be essential in identifying potential mechanisms by which CR acts in cancer prevention and delay of the aging process in long-lived species such as the rhesus monkey and humans. ..
  3. Primate enteroviruses transmission in Bangladesh
    Lisa Jones Engel; Fiscal Year: 2007
    ..Ultimately, this data will provide insight into the potential emergence of NHP-borne pathogens and help to deter the spread of emerging zoonotic threats. [unreadable] [unreadable]..