horse diseases

Summary

Summary: Diseases of domestic and wild horses of the species Equus caballus.

Top Publications

  1. pmc Tick-borne encephalitis virus in horses, Austria, 2011
    James O Rushton
    University of Veterinary Medicine, Vienna, Austria
    Emerg Infect Dis 19:635-7. 2013
  2. pmc Whole-genome SNP association in the horse: identification of a deletion in myosin Va responsible for Lavender Foal Syndrome
    Samantha A Brooks
    Department of Animal Science, College of Agriculture and Life Sciences, Cornell University, Ithaca, New York, United States of America
    PLoS Genet 6:e1000909. 2010
  3. pmc Seroprevalence of Toxoplasma gondii infection among horses in Tunisia
    Sonia Boughattas
    Laboratoire de Recherche 05SP03, Laboratoire de Parasitologie, Institut Pasteur de Tunis, 13 Place Pasteur BP74, 1002 Tunis Belvédères, Tunisia
    Parasit Vectors 4:218. 2011
  4. ncbi Establishment and characterization of equine fibroblast cell lines transformed in vivo and in vitro by BPV-1: model systems for equine sarcoids
    Z Q Yuan
    Institute of Comparative Medicine, University of Glasgow Faculty of Veterinary Medicine, Bearsden Road, Glasgow G61 1QH, UK
    Virology 373:352-61. 2008
  5. ncbi Expression of platelet-derived growth factor-beta receptor and bovine papillomavirus E5 and E7 oncoproteins in equine sarcoid
    G Borzacchiello
    Department of Pathology and Animal Health, Faculty of Veterinary Medicine, Naples University Federico II, Via F Delpino 1, 80137 Naples
    J Comp Pathol 139:231-7. 2008
  6. ncbi West Nile virus: epidemiology and ecology in North America
    Nicholas Komar
    Centers for Disease Control and Prevention, Division of Vector Borne Infectious Diseases, Fort Collins, Colorado 80522, USA
    Adv Virus Res 61:185-234. 2003
  7. ncbi West Nile virus lineage 2 as a cause of zoonotic neurological disease in humans and horses in southern Africa
    Marietjie Venter
    Department of Medical Virology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa
    Vector Borne Zoonotic Dis 10:659-64. 2010
  8. ncbi The ecology and epidemiology of Kunjin virus
    R A Hall
    Department of Microbiology and Parasitology, School of Molecular and Microbial Sciences, The University of Queensland, St Lucia, Queensland 4072, Australia
    Curr Top Microbiol Immunol 267:253-69. 2002
  9. pmc Comparative molecular analysis substantiates zoonotic potential of equine methicillin-resistant Staphylococcus aureus
    Birgit Walther
    Institute of Microbiology and Epizootics IMT, Free University Berlin, Philippstrasse 13, 10115 Berlin, Germany
    J Clin Microbiol 47:704-10. 2009
  10. ncbi High subclinical West Nile virus incidence among nonvaccinated horses in northern California associated with low vector abundance and infection
    Carrie F Nielsen
    Graduate Group in Epidemiology, Center for Vectorborne Diseases, Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine, and Department of Entomology, University of California, Davis, CA 95616, USA
    Am J Trop Med Hyg 78:45-52. 2008

Detail Information

Publications374 found, 100 shown here

  1. pmc Tick-borne encephalitis virus in horses, Austria, 2011
    James O Rushton
    University of Veterinary Medicine, Vienna, Austria
    Emerg Infect Dis 19:635-7. 2013
    ..1%) of tick-borne encephalitis virus (TBEV) was identified in a herd of 257 horses of the same breed distributed among 3 federal states in Austria. Young age (p<0.001) and male sex (p=0.001) were positively associated with infection...
  2. pmc Whole-genome SNP association in the horse: identification of a deletion in myosin Va responsible for Lavender Foal Syndrome
    Samantha A Brooks
    Department of Animal Science, College of Agriculture and Life Sciences, Cornell University, Ithaca, New York, United States of America
    PLoS Genet 6:e1000909. 2010
    ..The RFLP assay can be used to assist breeders in avoiding carrier-to-carrier matings and thus in preventing the birth of affected foals...
  3. pmc Seroprevalence of Toxoplasma gondii infection among horses in Tunisia
    Sonia Boughattas
    Laboratoire de Recherche 05SP03, Laboratoire de Parasitologie, Institut Pasteur de Tunis, 13 Place Pasteur BP74, 1002 Tunis Belvédères, Tunisia
    Parasit Vectors 4:218. 2011
    ..horses from three major regions: a neighbourhood of a city in the North (Sidi Thabet), a neighbourhood of a city on the coast (Monastir) and a neighbourhood of a city in the middle (Battan) of Tunisia (North of Africa)...
  4. ncbi Establishment and characterization of equine fibroblast cell lines transformed in vivo and in vitro by BPV-1: model systems for equine sarcoids
    Z Q Yuan
    Institute of Comparative Medicine, University of Glasgow Faculty of Veterinary Medicine, Bearsden Road, Glasgow G61 1QH, UK
    Virology 373:352-61. 2008
    ..These findings confirm that the virus has an active role in the induction of sarcoids and the lines will be invaluable for further studies on the role of BPV-1 in sarcoid pathology...
  5. ncbi Expression of platelet-derived growth factor-beta receptor and bovine papillomavirus E5 and E7 oncoproteins in equine sarcoid
    G Borzacchiello
    Department of Pathology and Animal Health, Faculty of Veterinary Medicine, Naples University Federico II, Via F Delpino 1, 80137 Naples
    J Comp Pathol 139:231-7. 2008
    ..These findings add further weight to the theory that BPV and the PDGF-betaR may have a role in the pathogenesis of this disease...
  6. ncbi West Nile virus: epidemiology and ecology in North America
    Nicholas Komar
    Centers for Disease Control and Prevention, Division of Vector Borne Infectious Diseases, Fort Collins, Colorado 80522, USA
    Adv Virus Res 61:185-234. 2003
  7. ncbi West Nile virus lineage 2 as a cause of zoonotic neurological disease in humans and horses in southern Africa
    Marietjie Venter
    Department of Medical Virology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa
    Vector Borne Zoonotic Dis 10:659-64. 2010
    ..Collectively, these studies suggest that lineage 2 WNV may be significantly under estimated as a cause of neurological disease in South Africa...
  8. ncbi The ecology and epidemiology of Kunjin virus
    R A Hall
    Department of Microbiology and Parasitology, School of Molecular and Microbial Sciences, The University of Queensland, St Lucia, Queensland 4072, Australia
    Curr Top Microbiol Immunol 267:253-69. 2002
  9. pmc Comparative molecular analysis substantiates zoonotic potential of equine methicillin-resistant Staphylococcus aureus
    Birgit Walther
    Institute of Microbiology and Epizootics IMT, Free University Berlin, Philippstrasse 13, 10115 Berlin, Germany
    J Clin Microbiol 47:704-10. 2009
    ..These data provide evidence for the adaptation of certain MRSA genotypes to more than one mammalian species, reflecting their extended host spectra...
  10. ncbi High subclinical West Nile virus incidence among nonvaccinated horses in northern California associated with low vector abundance and infection
    Carrie F Nielsen
    Graduate Group in Epidemiology, Center for Vectorborne Diseases, Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine, and Department of Entomology, University of California, Davis, CA 95616, USA
    Am J Trop Med Hyg 78:45-52. 2008
    ..pipiens and Cx. tarsalis, which served as both enzootic and bridge vectors amplifying WNV among birds and transmitting WNV to horses...
  11. ncbi High occurrence of methicillin-resistant Staphylococcus aureus ST398 in equine nasal samples
    A Van den Eede
    Department of Surgery and Anaesthesiology of Domestic Animals, Ghent University, Faculty of Veterinary Medicine, Salisburylaan 133, B 9820 Merelbeke, Belgium
    Vet Microbiol 133:138-44. 2009
    ..Due to its known interspecies transmission and the structure of the equine industry, the presence of this clone in horses poses a substantial health hazard for both animals and humans...
  12. ncbi Equine hospital data as a source for study of prevalence and heritability of osteochondrosis and palmar/plantar osseous fragments of Swedish Warmblood horses
    L Jonsson
    Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Sweden
    Equine Vet J 43:695-700. 2011
    ..However, there are few reports of such findings for epidemiological analyses or breeding purposes...
  13. ncbi Effect of adipose-derived nucleated cell fractions on tendon repair in horses with collagenase-induced tendinitis
    Alan J Nixon
    Comparative Orthopaedics Laboratory, Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853 6401, USA
    Am J Vet Res 69:928-37. 2008
    ..To assess the potential of adipose-derived nucleated cell (ADNC) fractions to improve tendon repair in horses with collagenase-induced tendinitis...
  14. ncbi Mesenchymal stem cells and insulin-like growth factor-I gene-enhanced mesenchymal stem cells improve structural aspects of healing in equine flexor digitorum superficialis tendons
    Lauren V Schnabel
    Comparative Orthopaedics Laboratory, Department of Clinical Sciences, C3 187 Veterinary Medical Center, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA
    J Orthop Res 27:1392-8. 2009
    ..Both MSC and AdIGF-MSC injection resulted in significantly improved tendon histological scores. These findings indicate a benefit to the use of MSCs and AdIGF-MSCs for the treatment of tendinitis...
  15. ncbi Bovine papillomaviruses: their role in the aetiology of cutaneous tumours of bovids and equids
    Lubna Nasir
    Division of Pathological Sciences, Institute of Comparative Medicine, University of Glasgow, Garscube Estate, Glasgow G61 1QH
    Vet Dermatol 19:243-54. 2008
    ..Only limited information on the clinical or pathological aspects of either bovine or equine tumours will be provided as this subject has been extensively addressed previously...
  16. ncbi Equine herpesvirus-1 consensus statement
    D P Lunn
    Department of Clinical Sciences, James L Voss Veterinary Teaching Hospital, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523 1620, USA
    J Vet Intern Med 23:450-61. 2009
    ..This consensus statement draws together current knowledge in the areas of pathogenesis, strain variation, epidemiology, diagnostic testing, vaccination, outbreak prevention and control, and treatment...
  17. ncbi Implantation of bone marrow-derived mesenchymal stem cells demonstrates improved outcome in horses with overstrain injury of the superficial digital flexor tendon
    E E Godwin
    Department of Veterinary Clinical Sciences, The Royal Veterinary College, Hatfield, UK
    Equine Vet J 44:25-32. 2012
    ..Mesenchymal stem (progenitor; stromal) cell (MSC) therapy has gained popularity for the treatment of equine tendon injuries but without reports of long-term follow-up...
  18. ncbi Bovine papillomavirus E7 oncoprotein binds to p600 in naturally occurring equine sarcoids
    Annunziata Corteggio
    Department of Pathology and Animal Health, Faculty of Veterinary Medicine, University of Naples Federico II, Via Veterinaria 1, 80137 Naples, Italy
    J Gen Virol 92:378-82. 2011
    ..Finally, the system provides a suitable animal model of papillomavirus-associated cancer to test therapeutic vaccination against E7...
  19. pmc Persistently infected horses are reservoirs for intrastadial tick-borne transmission of the apicomplexan parasite Babesia equi
    Massaro W Ueti
    Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164 7040, USA
    Infect Immun 76:3525-9. 2008
    ..equi transmission and that persistently infected horses are an important reservoir for transmission. Consequently, R. microplus male ticks and persistently infected horses should be targeted for disease control...
  20. ncbi Analysis of local spread of equine influenza in the Park Ridge region of Queensland
    J Davis
    Office of the Chief Veterinary Officer, Department of Agriculture Fisheries and Forestry, Canberra, Australia
    Transbound Emerg Dis 56:31-8. 2009
    ..The findings were consistent with the conclusion that EI will routinely spread over 1-2 km via wind-borne aerosol...
  21. pmc West Nile outbreak in horses in southern France, 2000: the return after 35 years
    B Murgue
    Centre National de Référence des Arbovirus et des Fièvres hémorragiques virales, Institut Pasteur 25, rue du Dr Roux, 75724 Paris Cedex 15, France
    Emerg Infect Dis 7:692-6. 2001
    ..No human case has been confirmed among clinically suspected patients, nor have abnormal deaths of birds been reported. A serosurvey has been undertaken in horses in the infected area, and other studies are in progress...
  22. pmc Lineage 2 west nile virus as cause of fatal neurologic disease in horses, South Africa
    Marietjie Venter
    University of Pretoria, Pretoria, South Africa
    Emerg Infect Dis 15:877-84. 2009
    ..In 5/7 horses, no other pathogen was detected. DNA sequencing for all 5 RT-PCR-positive cases showed the virus belonged to lineage 2. WNV lineage 2 may cause neurologic disease in horses in South Africa...
  23. ncbi Histopathological characteristics of five clinical types of equine sarcoid
    A Martens
    Department of Large Animal Surgery and Anaesthesiology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium
    Res Vet Sci 69:295-300. 2000
    ..The presence of other microscopic alterations was variable but could not be used in the differentiation of the clinical types based on histology...
  24. pmc Human Hendra virus encephalitis associated with equine outbreak, Australia, 2008
    Elliott G Playford
    Pathology Queensland, Brisbane, Queensland, Australia
    Emerg Infect Dis 16:219-23. 2010
    ..Emergence of Hendra virus is a serious medical, veterinary, and public health challenge...
  25. pmc West Nile virus isolation from equines in Argentina, 2006
    Maria Alejandra Morales
    Instituto Nacional de Enfermedades Virales Humanas, Dr Julio I Malztegui, Pergainino, Buenos Aires, Argentina
    Emerg Infect Dis 12:1559-61. 2006
    ..The horses were from different farms in central Argentina and had not traveled outside the country. This is the first isolation of WNV in South America...
  26. ncbi Methicillin-resistant Staphylococcus aureus in horses and horse personnel: an investigation of several outbreaks
    E van Duijkeren
    Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, PO Box 80165, 3508 TD Utrecht, Utrecht University, The Netherlands
    Vet Microbiol 141:96-102. 2010
    ..Our results show that nosocomial transmission occurs in equine clinics and suggests that personnel play a role in the transmission...
  27. ncbi West Nile virus activity in Latin America and the Caribbean
    Nicholas Komar
    Division of Vector Borne Infectious Diseases, Centers for Disease Control and Prevention, PO Box 2087, Fort Collins, Colorado 80522, USA
    Rev Panam Salud Publica 19:112-7. 2006
    ..West Nile virus (Flavivirus: Flaviviridae; WNV) has spread rapidly throughout the Caribbean Basin since its initial detection there in 2001. This report summarizes our current knowledge of WNV transmission in tropical America...
  28. ncbi Evaluation of prevalence and risk factors for methicillin-resistant Staphylococcus aureus colonization in veterinary personnel attending an international equine veterinary conference
    Maureen E C Anderson
    Department of Clinical Studies, Ontario Veterinary College, University of Guelph, Guelph, ON, Canada
    Vet Microbiol 129:410-7. 2008
    ..This is the first study to demonstrate a statistically significant association between hand hygiene practices and a measurable clinical outcome in veterinary medicine...
  29. ncbi Occurrence of Leishmania sp. in cutaneous lesions of horses in Central Europe
    Norbert Muller
    Institute of Parasitology, Vetsuisse Faculty, University of Berne, Länggass Str 122, CH 3012 Berne, Switzerland
    Vet Parasitol 166:346-51. 2009
    ..Future investigations will demonstrate if this form of leishmaniasis represents an emerging, and perhaps zoonotic, disease of European, or even global, importance...
  30. ncbi Neutrophil function of neonatal foals is enhanced in vitro by CpG oligodeoxynucleotide stimulation
    Angela I Bordin
    Department of Large Animal Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, TX 77843 4475, USA
    Vet Immunol Immunopathol 145:290-7. 2012
    ..05) increased IL-6 and IL-17 mRNA expression. We concluded that in vitro stimulation of foal neutrophils with CpG enhances their function by promoting degranulation and inducing mRNA expression of IL-6 and IL-17, regardless of age...
  31. ncbi The bacterial community of the horse gastrointestinal tract and its relation to fermentative acidosis, laminitis, colic, and stomach ulcers
    Rafat A M Al Jassim
    School of Animal Studies, The Faculty of Natural Resources, Agricultural and Veterinary Science, The University of Queensland, Gatton Campus, Queensland 4343, Australia
    Vet Clin North Am Equine Pract 25:199-215. 2009
    ....
  32. pmc Seroprevalence of Toxoplasma gondii in slaughtered horses and donkeys in Liaoning province, northeastern China
    Na Yang
    College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang, Liaoning Province 110866, China
    Parasit Vectors 6:140. 2013
    ..However, limited information is available about T. gondii infection in horses and donkeys in China. In the present study, we report the seroprevalence of T. gondii infection in horses and donkeys in Liaoning province, northeastern China...
  33. ncbi Post mortem evaluation of palmar osteochondral disease (traumatic osteochondrosis) of the metacarpo/metatarsophalangeal joint in Thoroughbred racehorses
    E D Barr
    Division of Veterinary Clinical Science, University of Liverpool, Leahurst, Neston, Cheshire, UK
    Equine Vet J 41:366-71. 2009
    ..The relationship between pathologies has not been elucidated, although it is widely accepted that POD is a manifestation of traumatic overload arthrosis...
  34. ncbi The relationship between in vivo limb and in vitro tendon mechanics after injury: a potential novel clinical tool for monitoring tendon repair
    S G Dakin
    Department of Veterinary Clinical Sciences, The Royal Veterinary College, Hertfordshire, UK
    Equine Vet J 43:418-23. 2011
    ..This study investigated the consequences of SDF tendinopathy on limb mechanics in relation to the mechanical properties of injured tendon...
  35. ncbi A genome-wide association study of osteochondritis dissecans in the Thoroughbred
    Laura J Corbin
    The Roslin Institute and Royal Dick School of Veterinary Studies, University of Edinburgh, Easter Bush Campus, Midlothian, EH25 9RG, Scotland, UK
    Mamm Genome 23:294-303. 2012
    ..The results of this study suggest that a significant challenge faced by equine researchers is the generation of sufficiently large data sets to effectively study complex diseases such as osteochondrosis...
  36. ncbi Horse owners'/managers' perceptions about effectiveness of biosecurity measures based on their experiences during the 2007 equine influenza outbreak in Australia
    K Schemann
    Faculty of Veterinary Science, The University of Sydney, 425 Werombi Road, Camden 2570, NSW, Australia
    Prev Vet Med 106:97-107. 2012
    ..This study identified factors associated with horse owners' and managers' perception of effectiveness of biosecurity measures. These findings should be considered in the design of infection control programs...
  37. ncbi Streptococcus equi subspecies zooepidemicus meningitis--a case report and review of the literature
    D W Eyre
    Infectious Diseases and Medical Microbiology, John Radcliffe Hospital, Oxford Radcliffe Hospitals NHS Trust, Headington, Oxford OX3 9DU, UK
    Eur J Clin Microbiol Infect Dis 29:1459-63. 2010
    ..Only 38% of patients made a complete recovery. Treatment regimes commonly included benzylpenicillin or a third-generation cephalosporin, with a mean treatment duration in survivors of 23 days...
  38. ncbi Equine multinodular pulmonary fibrosis: a newly recognized herpesvirus-associated fibrotic lung disease
    K J Williams
    College of Veterinary Medicine, Michigan State University, East Lansing, MI 48824, USA
    Vet Pathol 44:849-62. 2007
    ..Further, we propose that this newly described disease develops in association with infection by the equine gamma-herpesvirus, EHV-5...
  39. ncbi Real-time PCR for detection and differentiation of Streptococcus equi subsp. equi and Streptococcus equi subsp. zooepidemicus
    V Båverud
    Department of Bacteriology, National Veterinary Institute, SE 751 89 Uppsala, Sweden
    Vet Microbiol 124:219-29. 2007
    ..The real-time PCR system was found to be more sensitive than conventional cultivation as two additional field isolates of S. equi and four of S. zooepidemicus were detected...
  40. ncbi Chemoprophylactic effects of azithromycin against Rhodococcus equi-induced pneumonia among foals at equine breeding farms with endemic infections
    M Keith Chaffin
    Equine Infectious Disease Laboratory, Department of Large Animal Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, TX 77843 4475, USA
    J Am Vet Med Assoc 232:1035-47. 2008
    ....
  41. ncbi Evaluation of a multiplex polymerase chain reaction assay for simultaneous detection of Rhodococcus equi and the vapA gene
    Natalie D Halbert
    Department of Large Animal Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, TX 77843 4475, USA
    Am J Vet Res 66:1380-5. 2005
    ....
  42. pmc Equine piroplasmosis associated with Amblyomma cajennense Ticks, Texas, USA
    Glen A Scoles
    US Department of Agriculture and Washington State University, Pullman, Washington, USA
    Emerg Infect Dis 17:1903-5. 2011
    ..Amblyomma cajennense was the predominant tick and experimentally transmitted Theileria equi to an uninfected horse. We suggest that transmission by this tick species played a role in this outbreak...
  43. pmc Genome-wide association study among four horse breeds identifies a common haplotype associated with in vitro CD3+ T cell susceptibility/resistance to equine arteritis virus infection
    Yun Young Go
    Maxwell H Gluck Equine Research Center, Department of Veterinary Science, University of Kentucky, Lexington, KY 40546 0099, USA
    J Virol 85:13174-84. 2011
    ..To our knowledge, this is the first GWAS of an equine infectious disease and the first GWAS of equine viral arteritis...
  44. ncbi Analysis of multiyear studies in horses in Kentucky to ascertain whether counts of eggs and larvae per gram of feces are reliable indicators of numbers of strongyles and ascarids present
    M K Nielsen
    Department of Large Animal Sciences, Faculty of Life Sciences, University of Copenhagen, 5 Højbakkegård Alle, DK 2630 Taastrup, Denmark
    Vet Parasitol 174:77-84. 2010
    ..This supports usage of cutoffs for treatment in the 0-500 EPG range. Altogether, the present study yields unique and useful information of widely used methods for parasite surveillance and diagnosis in equine establishments...
  45. ncbi Evolution of multidrug-resistant Staphylococcus aureus infections in horses and colonized personnel in an equine clinic between 2005 and 2010
    Sandra Sieber
    Institute of Veterinary Bacteriology, University of Bern, Bern, Switzerland
    Microb Drug Resist 17:471-8. 2011
    ..Hygiene measures should, therefore, be maintained to limit the transmission of S. aureus between personnel and horses...
  46. ncbi Mapping of equine cerebellar abiotrophy to ECA2 and identification of a potential causative mutation affecting expression of MUTYH
    Leah S Brault
    Veterinary Genetics Laboratory, School of Veterinary Medicine, University of California, Davis, Davis, CA 95616, USA
    Genomics 97:121-9. 2011
    ..This SNP may therefore have a function effect on TOE1, or a regulatory effect on MUTYH by negatively affecting the binding affinity of GATA2...
  47. pmc Staphylococcus aureus colonization in healthy horses in Atlantic Canada
    Shelly Burton
    Atlantic Veterinary College, University of Prince Edward Island, 550 University Ave, Charlottetown, Prince Edward Island C1A 4P3
    Can Vet J 49:797-9. 2008
    ..Methicillin-susceptible S. aureus (MSSA) was isolated from a subsample of 19/242 (7.9%) horses. Colonization with MSSA is relatively common in healthy horses in Atlantic Canada, but MRSA is currently rare or absent...
  48. ncbi Outbreak of equine piroplasmosis in Florida
    Michael A Short
    Division of Animal Industry, Florida Department of Agriculture and Consumer Services, 407 S Calhoun St, Mayo Building, Tallahassee, FL 32399, USA
    J Am Vet Med Assoc 240:588-95. 2012
    ..The subsequent investigation included quarantine and testing of potentially exposed horses for B equi and Babesia caballi infections, tick surveillance, and owner-agent interviews...
  49. ncbi A review of tendon injury: why is the equine superficial digital flexor tendon most at risk?
    C T Thorpe
    University College London, Division of Surgery and Interventional Science, Institute of Orthopaedics and Musculoskeletal Science, Stanmore Campus, Royal National Orthopaedic Hospital, Stanmore, London HA7 4LP
    Equine Vet J 42:174-80. 2010
    ..An understanding of the mechanisms leading to matrix degeneration and subsequent tendon gross failure is the key to developing appropriate treatment and preventative measures...
  50. ncbi Activated platelet-derived growth factor beta receptor expression, PI3K-AKT pathway molecular analysis, and transforming signals in equine sarcoids
    G Borzacchiello
    Department of Pathology and Animal Health, Faculty of Veterinary Medicine, University of Naples Federico II, Via F Delpino, 1 80137, Naples, Italy
    Vet Pathol 46:589-97. 2009
    ..Our results provide new insights into the pathogenesis of equine sarcoids and support the validity of this in-vivo model to further characterize the molecular pathways underlying BPV E5-induced carcinogenesis...
  51. pmc Serology-enabled discovery of genetically diverse hepaciviruses in a new host
    Peter D Burbelo
    Neurobiology and Pain Therapeutics Section, Laboratory of Sensory Biology, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA
    J Virol 86:6171-8. 2012
    ..Together, these findings suggest a promising new nonprimate animal model and provide a database that will aid creation of functional NPHV cDNA clones and other novel tools for hepacivirus studies...
  52. ncbi Fatal encephalitis due to novel paramyxovirus transmitted from horses
    J D O'Sullivan
    Department of Neurology, Royal Brisbane Hospital, Herston, Queensland, Australia
    Lancet 349:93-5. 1997
    ..Fourteen horses and one human being died. A novel virus was isolated from those affected and named equine morbillivirus (EMV). We report a case of encephalitis caused by this virus...
  53. ncbi The equine influenza epidemic in Australia: spatial and temporal descriptive analyses of a large propagating epidemic
    Brendan Cowled
    Office of the Chief Veterinary Officer, Department of Agriculture, Fisheries and Forestry, GPO Box 858, Canberra, ACT 2601, Australia
    Prev Vet Med 92:60-70. 2009
    ..04 versus 1.99), cumulative incidence (27.4 versus 26.9) and incidence rates (1.36 versus 1.54) were similar. The relative impact of vaccination and national movement restrictions in controlling this epidemic needs further investigation...
  54. ncbi Results of a haplotype-based GWAS for recurrent laryngeal neuropathy in the horse
    Marie Capucine Dupuis
    Unit of Animal Genetics, GIGA Research, Faculty of Veterinary Medicine, University of Liege, 1 Avenue de l Hopital, B 4000 Liege, Belgium
    Mamm Genome 22:613-20. 2011
    ..62 × 10(-6)) and 31 (p = 1.69 × 10(-5)). The two signals were driven by the enrichment of a "protective" haplotype in controls compared to cases...
  55. ncbi A cross-sectional study of colic in horses on thoroughbred training premises in the British Isles in 1997
    M H Hillyer
    Equine Centre, Department of Clinical Veterinary Science, University of Bristol, Langford, North Somerset, UK
    Equine Vet J 33:380-5. 2001
    ....
  56. ncbi Prevalence of superficial digital flexor tendonitis and suspensory desmitis in Japanese Thoroughbred flat racehorses in 1999
    Y Kasashima
    Equine Research Institute, Japan Racing Association, 321 4, Tokami cho, Utsunomiya Shi, Tochigi, 320 0856, Japan
    Equine Vet J 36:346-50. 2004
    ..However, since tendon injury during training is seen commonly in clinical practice, it is appropriate to determine the overall prevalence of tendon injury sustained during both training and racing...
  57. ncbi Application of Sartwell's model (lognormal distribution of incubation periods) to age at onset and age at death of foals with Rhodococcus equi pneumonia as evidence of perinatal infection
    M L Horowitz
    Department of Large Animal Medicine and Surgery, College of Veterinary Medicine, Texas A and M University, College Station 77843-4475, USA
    J Vet Intern Med 15:171-5. 2001
    ..These results were consistent with the hypothesis that foals are infected with R. equi during the 1st several days of life, similar to a point-source exposure...
  58. pmc Evaluation of widely used diagnostic tests to detect West Nile virus infections in horses previously infected with St. Louis encephalitis virus or dengue virus type 2
    Jeremy P Ledermann
    Centers for Disease Control and Prevention, Division of Vector Borne Infectious Diseases, 3150 Rampart Road, Fort Collins, CO 80521, USA
    Clin Vaccine Immunol 18:580-7. 2011
    ..Of great importance, we demonstrated that timing of sample collection and the need for multiple samples are important, as the infecting etiology could be misdiagnosed if only a single sample is tested...
  59. ncbi Survival and complication rates in 300 horses undergoing surgical treatment of colic. Part 1: Short-term survival following a single laparotomy
    T S Mair
    Bell Equine Veterinary Clinic, Mereworth, Maidstone, Kent ME18 5GS, UK
    Equine Vet J 37:296-302. 2005
    ..Such information is required for owners and veterinary surgeons to make informed decisions about the most appropriate treatment for individual cases...
  60. ncbi Epidemiology of Rhodococcus equi infections: a review
    S Takai
    Department of Animal Hygiene, School of Veterinary Medicine and Animal Sciences, Kitasato University, Aomori, Japan
    Vet Microbiol 56:167-76. 1997
    ..equi, so regular examination of foals and their environment by virulence markers might be the most practical approach to control R. equi infection on endemic farms...
  61. ncbi Clusters of infections in horses with MRSA ST1, ST254, and ST398 in a veterinary hospital
    Christiane Cuny
    Wernigerode Branch, Robert Koch Institute, Wernigerode, Germany
    Microb Drug Resist 14:307-10. 2008
    ..The infections were caused by different MRSA clones (ST1, ST254, and ST398). In the same time, nasal colonization of veterinarians, veterinary personnel, and students was observed indicating transmission to humans...
  62. pmc Differential gene expression of TRPM1, the potential cause of congenital stationary night blindness and coat spotting patterns (LP) in the Appaloosa horse (Equus caballus)
    Rebecca R Bellone
    Department of Biology, University of Tampa, Tampa, FL 33606, USA
    Genetics 179:1861-70. 2008
    ..Decreased expression of TRPM1 in the eye and the skin may alter bipolar cell signaling as well as melanocyte function, thus causing both CSNB and LP in horses...
  63. ncbi A glycosylated peptide in the West Nile virus envelope protein is immunogenic during equine infection
    Jody Hobson-Peters
    School of Molecular and Microbial Sciences, The University of Queensland, St Lucia, Queensland 4072, Australia
    J Gen Virol 89:3063-72. 2008
    ..Together, these results suggest that the induction of antibodies to the WN19 epitope during WNV infection of horses is generally associated with E protein glycosylation of the infecting viral strain...
  64. ncbi The prevalence of methicillin-resistant staphylococci in healthy horses in the Netherlands
    J F Busscher
    Faculty of Veterinary Medicine, Utrecht University, Utrecht, Netherlands
    Vet Microbiol 113:131-6. 2006
    ..Further studies are needed in order to investigate whether horses can be a reservoir for MRS or the mecA gene for humans...
  65. ncbi Risk factors to tick infestations and their occurrence on horses in the state of São Paulo, Brazil
    M B Labruna
    Departamento de Medicina Veterinaria Preventiva e Saude Animal, Faculdade de Medicina Veterinaria e Zootecnia, Universidade de Sao Paulo, Av Prof Orlando Marques de Paiva, 87 Cidade Universitária, SP 05508 000, Sao Paulo, Brazil
    Vet Parasitol 97:1-14. 2001
    ..cajennense on the horses...
  66. pmc Epitope-blocking enzyme-linked immunosorbent assays for detection of west nile virus antibodies in domestic mammals
    Bradley J Blitvich
    Arthropod Borne and Infectious Diseases Laboratory, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado 80523, USA
    J Clin Microbiol 41:2676-9. 2003
    ..Sera were collected from experimentally infected horses, cats, and pigs at regular intervals and screened in ELISAs and plaque reduction neutralization tests. The diagnostic efficacies of these techniques were similar...
  67. ncbi Rhodococcus equi
    Wim G Meijer
    Department of Industrial Microbiology, Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin 4, Ireland
    Vet Res 35:383-96. 2004
    ..equi subverts normal macrophage killing mechanisms and cell-mediated immunity...
  68. pmc Ability of the vector tick Boophilus microplus to acquire and transmit Babesia equi following feeding on chronically infected horses with low-level parasitemia
    Massaro W Ueti
    Program in Vector Borne Diseases, Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164 7040, USA
    J Clin Microbiol 43:3755-9. 2005
    ..The results unequivocally demonstrated that chronically infected horses with low-level parasitemia are competent mammalian reservoirs for tick transmission of B. equi...
  69. pmc Analysis of equid herpesvirus 1 strain variation reveals a point mutation of the DNA polymerase strongly associated with neuropathogenic versus nonneuropathogenic disease outbreaks
    J Nugent
    Animal Health Trust, Lanwades Park, Kentford, Newmarket, Suffolk CB8 7UU, United Kingdom
    J Virol 80:4047-60. 2006
    ..Strikingly, this variant amino acid occurs at a highly conserved position for herpesvirus DNA polymerases, suggesting an important functional role...
  70. pmc West Nile virus, Venezuela
    Irene Bosch
    Emerg Infect Dis 13:651-3. 2007
  71. ncbi A dinucleotide mutation in the endothelin-B receptor gene is associated with lethal white foal syndrome (LWFS); a horse variant of Hirschsprung disease
    G C Yang
    Department of Surgical Research, Royal Alexandra Hospital for Children, Westmead, NSW 2145, Australia
    Hum Mol Genet 7:1047-52. 1998
    ..This was associated with LWFS when homozygous and with the overo phenotype when heterozygous...
  72. ncbi Comparison of owner-reported health problems with veterinary assessment of geriatric horses in the United Kingdom
    J L Ireland
    Department of Epidemiology and Public Health, University of Liverpool, Leahurst Campus, UK
    Equine Vet J 44:94-100. 2012
    ..Previous studies suggest that owners underestimate or incorrectly recognise or report health problems in geriatric horses. However, few studies have directly compared owner-reported and veterinary assessed disease...
  73. ncbi Congenital stationary night blindness is associated with the leopard complex in the Miniature Horse
    Lynne S Sandmeyer
    Department of Small Animal Clinical Sciences, University of Saskatchewan, Quill Lake, Saskatchewan, Canada
    Vet Ophthalmol 15:18-22. 2012
    ....
  74. ncbi Overview of current laminitis research
    Susan C Eades
    Department of Veterinary Clinical Sciences, Equine Health Studies Program, Louisiana State University, Baton Rouge, LA 70803, USA
    Vet Clin North Am Equine Pract 26:51-63. 2010
    ..However, scientific investigations are occurring at a phenomenal rate and shedding light on the pathophysiologic events involved with laminitis...
  75. ncbi Neospora spp. and Toxoplasma gondii antibodies in horses in the Czech Republic
    Eva Bartova
    Department of Biology and Wildlife Diseases, Faculty of Veterinary Hygiene and Ecology, University of Veterinary and Pharmaceutical Sciences, Palackeho 1 3, 612 42, Brno, Czech Republic
    Parasitol Res 107:783-5. 2010
    ..Antibodies against T. gondii were found in 125 (23%) horses. This is the first serologic survey for Neospora spp. antibodies performed on horses in the Czech Republic...
  76. ncbi Environmental risk factors for equine West Nile virus disease cases in Texas
    Michael P Ward
    Department of Veterinary Integrative Biosciences, Texas A and M University, College Station, TX 77843 4458, USA
    Vet Res Commun 33:461-71. 2009
    ..An understanding of environmental factors that increase equine WNV disease risk can be used to design and target disease control programs...
  77. ncbi Laminar inflammatory gene expression in the carbohydrate overload model of equine laminitis
    B S Leise
    Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, OH, USA
    Equine Vet J 43:54-61. 2011
    ..There is a need to assess the laminar inflammatory response in a laminitis model that more closely resembles clinical cases of sepsis-related laminitis than the black walnut extract (BWE) model...
  78. pmc Partners with bad temper: reject or cure? A study of chronic pain and aggression in horses
    Carole Fureix
    Universite Rennes 1, UMR CNRS 6552, Laboratoire Ethologie Animale et Humaine, Rennes, France
    PLoS ONE 5:e12434. 2010
    ....
  79. ncbi BPV-1 infection is not confined to the dermis but also involves the epidermis of equine sarcoids
    Sabine Brandt
    Equine Biotechnology Unit of Equine Clinic, University of Veterinary Medicine, Veterinaerplatz 1, A 1210 Vienna, Austria
    Vet Microbiol 150:35-40. 2011
    ..These findings indicate that BPV infection also involves the epidermis, where it may occasionally be productive...
  80. ncbi Detection of Lawsonia intracellularis by real-time PCR in the feces of free-living animals from equine farms with documented occurrence of equine proliferative enteropathy
    Nicola Pusterla
    Department of Medicine and Epidemiology, University of California, Davis, California 95616, USA
    J Wildl Dis 44:992-8. 2008
    ..Because the fecal samples were collected at equine farms with confirmed cases of EPE, striped skunks, Virginian opossums, jackrabbits, and coyotes may act as potential sources of infection to susceptible weanlings...
  81. pmc Cotton rats and house sparrows as hosts for North and South American strains of eastern equine encephalitis virus
    Nicole C Arrigo
    Institute for Human Infections and Immunity and Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555 0609, USA
    Emerg Infect Dis 16:1373-80. 2010
    ..Our findings suggested that each species has the potential to serve as amplification hosts for North and South America EEEVs...
  82. ncbi Frequency distributions of 174 fractures of the distal condyles of the third metacarpal and metatarsal bones in 167 Thoroughbred racehorses (1999-2009)
    B D Jacklin
    Newmarket Equine Hospital, Suffolk, UK
    Equine Vet J 44:707-13. 2012
    ..Additionally, grouped analyses of previous studies from the UK and USA would permit comparison between study groups and the creation of a substantial pool of international data...
  83. pmc Human cases of methicillin-resistant Staphylococcus aureus CC398, Finland
    Saara Salmenlinna
    National Institute for Health and Welfare, Department of Infectious Disease Surveillance and Control, Helsinki, Finland
    Emerg Infect Dis 16:1626-9. 2010
    ..These findings may indicate unrecognized community transmission...
  84. ncbi Clara cell secretory protein is reduced in equine recurrent airway obstruction
    P Katavolos
    Department of Pathobiology, University of Guelph, Guelph, ON, N1G 2W1, Canada
    Vet Pathol 46:604-13. 2009
    ..Together, these preliminary findings suggest that reduced production of CCSP and subcellular changes in Clara cells are features of chronic environmentally induced lung inflammation in horses...
  85. ncbi Pathological studies of cheek teeth apical infections in the horse: 4. Aetiopathological findings in 41 apically infected mandibular cheek teeth
    I T Dacre
    Division of Veterinary Clinical Science, The Royal Dick School of Veterinary Studies, The University of Edinburgh, Easter Bush Veterinary Centre, Midlothian EH25 9RG, UK
    Vet J 178:341-51. 2008
    ....
  86. ncbi Equine gammaherpesviruses: pathogenesis, epidemiology and diagnosis
    Guillaume Fortier
    Frank Duncombe Laboratory, 14053 Caen Cedex 4, France
    Vet J 186:148-56. 2010
    ..Future molecular biological studies will further elucidate the virulence mechanisms of these equine pathogens...
  87. ncbi Genetic parameters of insect bite hypersensitivity in Dutch Friesian broodmares
    A Schurink
    Animal Breeding and Genomics Centre, Wageningen University, PO Box 338, 6700 AH Wageningen, The Netherlands
    J Anim Sci 89:1286-93. 2011
    ..The dam affected the IBH development of her offspring through an additive genetic influence but also by being part of their rearing environment...
  88. ncbi Attempted eradication of methicillin-resistant staphylococcus aureus colonisation in horses on two farms
    J S Weese
    Department of Clinical Studies, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada
    Equine Vet J 37:510-4. 2005
    ..Infection control protocols can be used to control MRSA in human hospitals, but measures to eradicate MRSA on horse farms have not been evaluated...
  89. ncbi Rotavirus-associated diarrhoea in foals in Greece
    V Ntafis
    Agricultural University of Athens, Faculty of Animal Science and Aquaculture, Iera Odos 75, 118 55 Athens, Greece
    Vet Microbiol 144:461-5. 2010
    ..All Greek equine rotavirus isolates were genetically identical, suggesting persistence of the same viral strain in the stud farm, over the two consecutive foaling periods...
  90. ncbi A case-control study of risk factors for equine influenza spread onto horse premises during the 2007 epidemic in Australia
    Simon M Firestone
    Faculty of Veterinary Science, The University of Sydney, Camden, NSW 2570, Australia
    Prev Vet Med 100:53-63. 2011
    ..In future outbreaks, in addition to broader disease control measures, on-farm biosecurity practices should be adopted by horse owners and managers to prevent equine influenza spread...
  91. ncbi Gastrointestinal parasitic worms in equines in the Paraíba Valley, State of São Paulo, Brazil
    J R Pereira
    APTA, São Paulo State Agribusiness Technology Agency, Paraíba Valley Regional Agribusiness Technological Regional Development Hub PO Box 07, 12 411 010 Pindamonhangaba, SP, Brazil
    Vet Parasitol 140:289-95. 2006
    ..No specimens of flukes (Trematoda) were found in any of the animals studied...
  92. ncbi Equine recurrent uveitis--a spontaneous horse model of uveitis
    Cornelia A Deeg
    Institute of Animal Physiology, LMU Munich, Munich, Germany
    Ophthalmic Res 40:151-3. 2008
    ....
  93. pmc Glycoproteins D of equine herpesvirus type 1 (EHV-1) and EHV-4 determine cellular tropism independently of integrins
    Walid Azab
    Institut fur Virologie, Freie Universitat Berlin, Berlin, Germany
    J Virol 86:2031-44. 2012
    ..Cumulatively, we provide evidence that efficient EHV-1 and EHV-4 entry is dependent mainly on gD, which can bind to multiple cell surface receptors, and that gD has a defining role with respect to cellular host range of EHV-1 and EHV-4...
  94. pmc Experimental infection of horses with West Nile virus
    Michel L Bunning
    Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Emerg Infect Dis 8:380-6. 2002
    ..Horses infected with the NY99 strain of WNV develop low viremia levels of short duration; therefore, infected horses are unlikely to serve as important amplifying hosts for WNV in nature...
  95. ncbi Prevalence of antibodies to Toxoplasma gondii in horses in Riyadh Province, Saudi Arabia
    Abdulah D Alanazi
    Department of Quality Inspection, Ministry of Commerce, P O Box 122331, Riyadh 11721, Saudi Arabia
    J Parasitol 97:943-5. 2011
    ..Horses are not a direct source of infection for human toxoplasmosis in this region. Usually human infection is facilitated via cats, which are the reservoir hosts for this parasite...
  96. ncbi Prevalence of Clostridium difficile in horses
    Carlos E Medina-Torres
    Department of Clinical Studies, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada
    Vet Microbiol 152:212-5. 2011
    ..01% for C. difficile was identified in 742 fecal samples. PCR-ribotyping and toxin gene identification was performed and seventeen 17 PCR-ribotypes were identified among the 52 C. difficile isolates...
  97. ncbi Report of the 3rd Havemeyer workshop on allergic diseases of the Horse, Hólar, Iceland, June 2007
    E Marti
    Department of Clinical Veterinary Medicine, Vetsuisse Faculty, University of Berne, 3001 Berne, Switzerland
    Vet Immunol Immunopathol 126:351-61. 2008
    ..This suggests that environmental or epigenetic factors may contribute to this response. This report summarizes the present state of knowledge and summarizes important issues discussed at the workshop...
  98. ncbi Ulcerative keratitis in thoroughbred racehorses in Japan from 1997 to 2008
    Shinya Wada
    Clinical Science and Pathobiology Division, Equine Research Institute ERI, Japan Racing Association JRA, 321 4, Tokami cho, Utsunomiya, Tochigi 320 0856, Japan
    Vet Ophthalmol 13:99-105. 2010
    ..To describe the number of cases, etiologies, healing times, and results of microbial culture and susceptibility testing of corneal ulcers in thoroughbred racehorses in Japan...
  99. ncbi Diagnosis, treatment, control, and prevention of infections caused by Rhodococcus equi in foals
    S Giguere
    Department of Large Animal Medicine, University of Georgia, Athens, GA 30602, USA
    J Vet Intern Med 25:1209-20. 2011
    ..equi may be very high. The purpose of this consensus statement is to provide recommendations regarding the diagnosis, treatment, control, and prevention of infections caused by R. equi in foals...
  100. ncbi Hendra virus infection in a veterinarian
    Jeffrey N Hanna
    Queensland Health, Cairns, QLD, Australia
    Med J Aust 185:562-4. 2006
    ..Nevertheless, she remains well 2 years after her initial illness. Recently emerged zoonotic viruses, such as HeV, necessitate appropriate working procedures and personal protective equipment in veterinary practice...
  101. ncbi Fluorescence in situ hybridization analysis of hindgut bacteria associated with the development of equine laminitis
    Gabriel J Milinovich
    Australian Equine Laminitis Research Unit, School of Veterinary Science, The University of Queensland, Brisbane, QLD, Australia
    Environ Microbiol 9:2090-100. 2007
    ....

Research Grants35

  1. PTHrP on normal osteoblast differentiation and function
    RAMIRO TORIBIO; Fiscal Year: 2008
    ..Dr. Thomas Rosol's laboratory will provide an excellent environment for developing the skills necessary to become a successful independent researcher. ..
  2. Small Laboratory Animal Imaging: High Resolution Microcomputed Tomography System
    RAMIRO TORIBIO; Fiscal Year: 2006
    ..Salary and benefits for the Supervisor and Space and utilities for the instrument will be provided by Department of Veterinary Biosciences and the College of Veterinary Medicine. [unreadable] [unreadable]..
  3. Etiologic studies on EMND: An animal model for ALS
    Hussni Mohammed; Fiscal Year: 2004
    ..Data obtained from these pilot studies will represent a major breakthrough towards the understanding of the mechanism of the motor neuron disease and lay the foundation for more thorough investigation. ..
  4. GTPase Activating Proteins in Aging and Osteoarthritis
    Lisa Fortier; Fiscal Year: 2007
    ..We anticipate that these findings will facilitate identification of target molecules for development of therapeutics modalities for OA. [unreadable] [unreadable] [unreadable]..
  5. EIAV Control by DNA Vaccine-Induced CTL
    ROBERT MEALEY; Fiscal Year: 2006
    ..The information obtained from the proposed studies should have implications for HIV-1 vaccine design, where experiments of this type may be more difficult. [unreadable] [unreadable]..
  6. MICROARRAY ANALYSIS OF RETINAL DEGENERATION IN MICE
    Caroline Zeiss; Fiscal Year: 2007
    ..Colin Barnstable, Professor of Neurobiology and Ophthalmology, who is an internationally recognized molecular biologist using mouse models of retinal development and degeneration. ..
  7. Comparison of Human Ehrlichiosis Agent Genomes
    Yasuko Rikihisa; Fiscal Year: 2010
    ..chaffeensis virulence determinants and their pathogenic mechanisms. The results may point to potential chemotherapy, chemopreventive and/or vaccine candidates for treatment and prevention of human ehrlichiosis. ..
  8. Adeno-associated virus for IGF-I cartilage gene therapy
    Alan Nixon; Fiscal Year: 2003
    ..abstract_text> ..
  9. MOLECULAR ANALYSIS OF A NEUROTROPIC AGENT--BORNA VIRUS
    WALTER LIPKIN; Fiscal Year: 2002
    ....
  10. ROLES OF EHRLICHIAL OUTER MEMBRANE PROTEIN IN PARASITISM
    Yasuko Rikihisa; Fiscal Year: 2001
    ..Aim 5 addresses hypothesis 3 by examining the effects of immunization with the ehrlichial OMP in a mouse model of human ehrlichiosis. ..
  11. MUSCLE CAPILLARY GEOMETRY, FLOW, AND OXYGEN TRANSFER
    David Poole; Fiscal Year: 2001
    ....
  12. Pathogen Discovery in Chronic Lung Disease by Mass Tag PCR and Microarray
    W Ian Lipkin; Fiscal Year: 2009
    ....
  13. GENES CONTROLLING VIRUS INDUCED ASTHMA IN RATS
    William Castleman; Fiscal Year: 2002
    ....
  14. GENE EXPRESSION BY HUMAN GRANULOCYTIC EHRLICHIOSIS AG
    Yasuko Rikihisa; Fiscal Year: 2004
    ..These efforts are expected to reveal an important role for the p44-multigene family in strategies of adaptive surface variation and avoidance of host immune responses. ..
  15. Ehrilchiacidal Mechanisms In Leukocytes
    Yasuko Rikihisa; Fiscal Year: 2009
    ..The results may point to a potential target for new treatment and prevention of HME and HGE. ..
  16. Glioma Therapeutics Targeting Glioma Pathogenesis-related Protein
    Nathalie Bonafe; Fiscal Year: 2008
    ..Our project is designed to develop new therapeutics to combat the highly aggressive and invasive malignant behavior of brain tumors. [unreadable] [unreadable] [unreadable]..
  17. A Staged Strategy for Virus Identification and Discovery
    W Ian Lipkin; Fiscal Year: 2005
    ..Our initial focus will be two chronic diseases where specific viral taxa are associated and potentially implicated in pathogenesis: bronchioalveolar cell carcinoma and amyotrophic lateral sclerosis. ..
  18. ECOLOGY AND GENETICS OF VENEZUELAN EQUINE ENCEPHALITIS
    Scott Weaver; Fiscal Year: 2005
    ..This information will be invaluable in targeting prevention and control resources, especially for obtaining maximum benefit in developing countries with limited resources. ..
  19. Mass Tag PCR Detection of Respiratory Pathogens
    W Ian Lipkin; Fiscal Year: 2004
    ..abstract_text> ..
  20. BORNA DISEASE VIRUS AND NEUROPSYCHIATRIC DISEASE
    WALTER LIPKIN; Fiscal Year: 2002
    ..This study will be the first to collect and process human sera and PBMC samples in clinical laboratories with no history of BDV research and dispense aliquots to a central laboratory for randomized, blinded analysis. ..
  21. MECHANISMS OF PROSTAGLANDIN INDUCED INTESTINAL REPAIR
    Anthony Blikslager; Fiscal Year: 2002
    ..These experiments will provide insight into the signaling pathways and mechanisms by which prostaglandins trigger repair of acutely-injured intestinal epithelium. ..
  22. A Staged Strategy for Virus Identification and Discovery
    WALTER LIPKIN; Fiscal Year: 2004
    ..Consistent with aims proposed in AI51292, our initial clinical application will be to analyze enteroviral serotypes implicated in human disease in North America. ..
  23. A DEVELOPMENTAL MODEL FOR AUTISM BASED ON CNS INFECTION
    WALTER LIPKIN; Fiscal Year: 2004
    ..4) Determine how opoptosis contributes to the neuropathology observed after neonatal infection. (5) Analyze regional changes in neurotransmitter systems following neonatal infection. ..
  24. ARBOVIRUS PERSISTENCE IN SEASONAL WETLANDS
    William Reisen; Fiscal Year: 2002
    ..Virus ecology at wetlands in the Coachella Valley of southeastern California with consistent enzootic activity will be compared with wetlands in the southern San Joaquin Valley where virus activity currently is intermittent. ..
  25. Thioredoxin in Neutrophil-Airway Epithelial Interactions
    Karen Oslund; Fiscal Year: 2008
    ..She hopes to use a career research award to gain additional knowledge and training in molecular biology while transitioning to an independent researcher who will be competitive for R01 funding. [unreadable] [unreadable] [unreadable]..
  26. HOST COMPETENCE FACTORS AFFECT ARBOVIRUS TRANSMISSION
    William Reisen; Fiscal Year: 2003
    ..Studies will assess how alternating sequential infections between vertebrate and vector species that are part of the natural transmission cycle may alter virus genetics and fitness. ..
  27. Mechanisms Causing Cryptorchidism and Fetal Transformation of Testicular Cells
    D N Rao Veeramachaneni; Fiscal Year: 2007
    ..Results will clarify the interaction of genetics and EDAs as cause of cryptorchidism. [unreadable] [unreadable] [unreadable]..
  28. Growth factor gene mediated cartilage repair
    LAURIE GOODRICH; Fiscal Year: 2004
    ..abstract_text> ..
  29. The molecular basis for an animal model of inherited hyperuricosuria
    Danika Bannasch; Fiscal Year: 2007
    ..The elucidation of a novel gene function should provide new avenues of investigation for the treatment of the human condition. [unreadable] [unreadable] [unreadable]..
  30. Fetal Basis of Sexual Dysfunction: Brain Differentiation
    D N Rao Veeramachaneni; Fiscal Year: 2007
    ..By using a relevant and yet practical animal model the proposed studies will advance the knowledge base in pollutant-induced sexual/erectile dysfunction, an area pivotal to reproductive health/success in humans. [unreadable] [unreadable]..
  31. EIAV Control by High Avidity Rev-Specific CTL Clones
    ROBERT MEALEY; Fiscal Year: 2005
    ..The information obtained from the proposed studies should have implications for HIV-1 immunotherapy and vaccine design, where experiments of this type may be more difficult. ..
  32. MOLECULAR MECHANISMS OF EIAV PERSISTENCE
    JERALD OAKS; Fiscal Year: 2001
    ..These studies will provide insight into HIV persistence in HAART patients, and potentially provide a model that can be used to evaluate strategies for actual elimination of lentiviral infections. ..
  33. Photoperiod, melatonin, and reproductive aging
    NED PLACE; Fiscal Year: 2008
    ..Once the objectives of this award have been met, the candidate will work as an independent investigator, and carry out research on reproductive aging that is truly integrative. ..
  34. Functional analysis of C. perfringens epsilon toxin
    J Songer; Fiscal Year: 2006
    ..This information can be used to model the mode of action of ETX, and to define regions of the molecule that could be targeted for immunoprophylaxis and treatment. ..