goat diseases

Summary

Summary: Diseases of the domestic or wild goat of the genus Capra.

Top Publications

  1. ncbi Comparison of Coxiella burnetii shedding in milk of dairy bovine, caprine, and ovine herds
    A Rodolakis
    INRA, UR1282, Infectiologie Animale et Sante Publique, Centre de Recherche de Tours, 37380 Nouzilly, France
    J Dairy Sci 90:5352-60. 2007
  2. ncbi The Q fever epidemic in The Netherlands: history, onset, response and reflection
    H I J Roest
    Department of Bacteriology and TSEs, Central Veterinary Institute of Wageningen UR, Lelystad, The Netherlands
    Epidemiol Infect 139:1-12. 2011
  3. ncbi Routes of transmission and consequences of small ruminant lentiviruses (SRLVs) infection and eradication schemes
    Ernst Peterhans
    Institute of Veterinary Virology, University of Bern, Bern, Switzerland
    Vet Res 35:257-74. 2004
  4. ncbi Small ruminant lentivirus genotype E is widespread in Sarda goat
    Ramses Reina
    Dipartimento di Produzioni Animali, Epidemiologia, Ecologia, Facolta di Medicina Veterinaria, Universita degli Studi di Torino, Via Leonardo da Vinci 44, 10095 Grugliasco, TO, Italy
    Vet Microbiol 144:24-31. 2010
  5. pmc Ovine TRIM5α can restrict visna/maedi virus
    P Jáuregui
    Instituto de Agrobiotecnologia, CSIC UPNA Gobierno de Navarra, Mutilva Baja, Navarra, Spain
    J Virol 86:9504-9. 2012
  6. ncbi Viral load, organ distribution, histopathological lesions, and cytokine mRNA expression in goats infected with a molecular clone of the caprine arthritis encephalitis virus
    Ana Paula Ravazzolo
    Institute of Veterinary Virology, University of Bern, Laenggass Str 122, CH 3012, Switzerland
    Virology 350:116-27. 2006
  7. ncbi Prevalence of Coxiella burnetii infection in domestic ruminants: a critical review
    Raphaël Guatteo
    INRA, UMR 1300 Bio Agression, Epidémiologie et Analyse de Risque, Nantes F 44307, France
    Vet Microbiol 149:1-16. 2011
  8. ncbi Genetic characterization of small ruminant lentivirus in Italian mixed flocks: evidence for a novel genotype circulating in a local goat population
    Elena Grego
    Dipartimento di Produzioni Animali, Epidemiologia, Ecologia, Facolta di Medicina Veterinaria, Universita degli Studi di Torino, Via Leonardo da Vinci 44, 10095 Grugliasco TO, Italy
    J Gen Virol 88:3423-7. 2007
  9. ncbi Characterization of new small ruminant lentivirus subtype B3 suggests animal trade within the Mediterranean Basin
    L Bertolotti
    Dipartimento di Produzioni Animali, Universita degli Studi di Torino, Grugliasco, Italy
    J Gen Virol 92:1923-9. 2011
  10. ncbi Transmission of small ruminant lentiviruses
    B A Blacklaws
    Department of Clinical Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 0ES, UK
    Vet Microbiol 101:199-208. 2004

Research Grants

  1. IMMUNE CONTROL OF CAE LENTIVIRUS
    Donald Knowles; Fiscal Year: 2005
  2. TRICHINELLOSIS AND REGULATION OF HOST GENE EXPRESSION
    Douglas Jasmer; Fiscal Year: 2001
  3. Novel Integrative Genetic Elements of Mycoplasmas
    Michael Calcutt; Fiscal Year: 2003
  4. GTPase Activating Proteins in Aging and Osteoarthritis
    Lisa Fortier; Fiscal Year: 2007
  5. Spiroplasma 16S rDNA in TSE Brain Tissues
    Frank Bastian; Fiscal Year: 2006
  6. Antigenic variation in rickettsial transmission
    Guy Palmer; Fiscal Year: 2008

Detail Information

Publications279 found, 100 shown here

  1. ncbi Comparison of Coxiella burnetii shedding in milk of dairy bovine, caprine, and ovine herds
    A Rodolakis
    INRA, UR1282, Infectiologie Animale et Sante Publique, Centre de Recherche de Tours, 37380 Nouzilly, France
    J Dairy Sci 90:5352-60. 2007
    ..The detection of antibodies in milk seems more sensitive than it is in serum...
  2. ncbi The Q fever epidemic in The Netherlands: history, onset, response and reflection
    H I J Roest
    Department of Bacteriology and TSEs, Central Veterinary Institute of Wageningen UR, Lelystad, The Netherlands
    Epidemiol Infect 139:1-12. 2011
    ..In general good monitoring and surveillance systems are necessary to assess the real magnitude of Q fever...
  3. ncbi Routes of transmission and consequences of small ruminant lentiviruses (SRLVs) infection and eradication schemes
    Ernst Peterhans
    Institute of Veterinary Virology, University of Bern, Bern, Switzerland
    Vet Res 35:257-74. 2004
    ..This paper brings together existing information regarding these questions and identifies areas for future research...
  4. ncbi Small ruminant lentivirus genotype E is widespread in Sarda goat
    Ramses Reina
    Dipartimento di Produzioni Animali, Epidemiologia, Ecologia, Facolta di Medicina Veterinaria, Universita degli Studi di Torino, Via Leonardo da Vinci 44, 10095 Grugliasco, TO, Italy
    Vet Microbiol 144:24-31. 2010
    ..Data presented suggest diffusion of genotype E is wider than previously thought...
  5. pmc Ovine TRIM5α can restrict visna/maedi virus
    P Jáuregui
    Instituto de Agrobiotecnologia, CSIC UPNA Gobierno de Navarra, Mutilva Baja, Navarra, Spain
    J Virol 86:9504-9. 2012
    ..Identification of TRIM5α active molecular species may open new prophylactic strategies against lentiviral infections...
  6. ncbi Viral load, organ distribution, histopathological lesions, and cytokine mRNA expression in goats infected with a molecular clone of the caprine arthritis encephalitis virus
    Ana Paula Ravazzolo
    Institute of Veterinary Virology, University of Bern, Laenggass Str 122, CH 3012, Switzerland
    Virology 350:116-27. 2006
    ..The mRNA expression analysis of several cytokines did not reveal differences between animals that could explain the considerable individual variations in viral load observed...
  7. ncbi Prevalence of Coxiella burnetii infection in domestic ruminants: a critical review
    Raphaël Guatteo
    INRA, UMR 1300 Bio Agression, Epidémiologie et Analyse de Risque, Nantes F 44307, France
    Vet Microbiol 149:1-16. 2011
    ..The present conclusions and the current situation support the persistent need of conducting well designed studies, aiming at estimating the true prevalence of C. burnetii infection in the three main domestic ruminant species...
  8. ncbi Genetic characterization of small ruminant lentivirus in Italian mixed flocks: evidence for a novel genotype circulating in a local goat population
    Elena Grego
    Dipartimento di Produzioni Animali, Epidemiologia, Ecologia, Facolta di Medicina Veterinaria, Universita degli Studi di Torino, Via Leonardo da Vinci 44, 10095 Grugliasco TO, Italy
    J Gen Virol 88:3423-7. 2007
    ..A recombinant subunit ELISA, based on genotype E-specific epitopes, was developed and a third independent flock carrying this genotype was identified, based on serology...
  9. ncbi Characterization of new small ruminant lentivirus subtype B3 suggests animal trade within the Mediterranean Basin
    L Bertolotti
    Dipartimento di Produzioni Animali, Universita degli Studi di Torino, Grugliasco, Italy
    J Gen Virol 92:1923-9. 2011
    ....
  10. ncbi Transmission of small ruminant lentiviruses
    B A Blacklaws
    Department of Clinical Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 0ES, UK
    Vet Microbiol 101:199-208. 2004
    ..However, such transmission has not been demonstrated to date. The application of control measures based on this information allows more efficient strategies to be developed which will reduce the rate of transmission...
  11. ncbi Prevention strategies against small ruminant lentiviruses: an update
    Ramses Reina
    Institute of Agrobiotechnology CSIC UPNA Government of Navarra, 31192 Mutilva Baja, Spain
    Vet J 182:31-7. 2009
    ..This review updates the knowledge on diagnosis, risk of infection, immunisation approaches and criteria for selecting the different strategies to control the spread of SRLVs...
  12. ncbi Diagnostic tests for small ruminant lentiviruses
    D de Andres
    Institute of Agrobiotechnology and Natural Resources, Pamplona, Spain
    Vet Microbiol 107:49-62. 2005
    ..Here we review recent developments in laboratory diagnostic methods and their use in field diagnosis. The results suggest that a combination of ELISA and PCR might afford optimal detection of SRLV infection...
  13. pmc The detection of antibodies against peste des petits ruminants virus in cattle, sheep and goats and the possible implications to rinderpest control programmes
    J Anderson
    ARFC Institute for Animal Health, Pirbright Laboratory, Woking, Surrey, UK
    Epidemiol Infect 112:225-31. 1994
    ....
  14. ncbi Phylogenetic analysis and reclassification of caprine and ovine lentiviruses based on 104 new isolates: evidence for regular sheep-to-goat transmission and worldwide propagation through livestock trade
    Cyril Shah
    Swiss National Center for Retroviruses, University of Zurich, Zurich, Switzerland
    Virology 319:12-26. 2004
    ..Furthermore, infection of goats by subtypes A3 or A4 was significantly associated with documented contact with sheep, which also harbor these subtypes, thus indicating regularly occurring sheep-to-goat transmission...
  15. pmc State-of-the-art review of goat TSE in the European Union, with special emphasis on PRNP genetics and epidemiology
    Gabriele Vaccari
    Department of Food Safety and Veterinary Public Health, Unit of Transmissible Spongiform Encephalopathies and Emerging Infectious Diseases of Animals, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161, Rome, Italy
    Vet Res 40:48. 2009
    ..This review presents the current knowledge of the epidemiology of caprine scrapie within the major European goat populations, and compiles the current data on genetic variability of PRNP...
  16. pmc The use of a geographic information system to identify a dairy goat farm as the most likely source of an urban Q-fever outbreak
    Barbara Schimmer
    Centre for Infectious Disease Control, National Institute for Public Health and the Environment, A van Leeuwenhoeklaan 9, PO Box 1, 3720 BA Bilthoven, The Netherlands
    BMC Infect Dis 10:69. 2010
    ..A generic geographic information system (GIS) was used to develop a method for source detection in the still evolving major epidemic of Q-fever in the Netherlands...
  17. pmc Molecular epidemiology of Coxiella burnetii from ruminants in Q fever outbreak, the Netherlands
    Hendrik I J Roest
    Central Veterinary Institute, part of Wageningen UR, Lelystad, The Netherlands
    Emerg Infect Dis 17:668-75. 2011
    ..On the basis of 4 loci, this genotype is similar to a human genotype from the Netherlands. This finding strengthens the probability that this genotype of C. burnetii is responsible for the human Q fever epidemic in the Netherlands...
  18. ncbi Novel polymorphisms at codons 146 and 151 in the prion protein gene of Cyprus goats, and their association with natural scrapie
    Penelope Papasavva-Stylianou
    Virology Laboratory, Veterinary Services, 1417 Nicosia, Cyprus
    Vet J 173:459-62. 2007
    ..The two novel polymorphisms at codon 146 were found only in the healthy control and scrapie-negative goats. By comparison, none of the scrapie-affected goats encoded these polymorphisms...
  19. ncbi The effect of caprine arthritis encephalitis virus infection on production in goats
    G Leitner
    National Mastitis Reference Center, Kimron Veterinary Institute, P O Box 12, Bet Dagan 50250, Israel
    Vet J 183:328-31. 2010
    ..This finding could be attributed to lateral virus transmission from seropositive to seronegative kids because of lack of segregation within the flock...
  20. ncbi First evidence of peste des petits ruminants (PPR) virus circulation in Algeria (Sahrawi territories): outbreak investigation and virus lineage identification
    M de Nardi
    Istituto Zooprofilattico Sperimentale delle Venezie, Legnaro PD, Italy
    Transbound Emerg Dis 59:214-22. 2012
    ..3% of the samples. Sequence analysis revealed that the virus belonged to Lineage IV and phylogenetic analysis indicated a close relationship (99.3%) with the PPRV isolated during the Moroccan outbreak in 2008...
  21. ncbi Mycoplasma conjunctivae infection is not maintained in alpine chamois in eastern Switzerland
    Marco Giacometti
    Wildvet Projects, CH 7605 Stampa, Switzerland
    J Wildl Dis 38:297-304. 2002
    ..The agent may originate in domestic sheep living in proximity to chamois during summer. Control of IKC in chamois should consider immunoprophylaxis in sheep or limiting interspecific transmission of M. conjunctivae...
  22. ncbi Use of the Capripoxvirus homologue of Vaccinia virus 30 kDa RNA polymerase subunit (RPO30) gene as a novel diagnostic and genotyping target: development of a classical PCR method to differentiate Goat poxvirus from Sheep poxvirus
    Charles Euloge Lamien
    Animal Production and Health Laboratory, FAO IAEA Agriculture and Biotechnology Laboratory, IAEA Laboratories Seibersdorf, International Atomic Energy Agency, Wagramer Strasse 5, P O Box 100, A1400 Vienna, Austria
    Vet Microbiol 149:30-9. 2011
    ....
  23. ncbi Prime-boost vaccination with plasmid DNA encoding caprine-arthritis encephalitis lentivirus env and viral SU suppresses challenge virus and development of arthritis
    W P Cheevers
    Department of Microbiology and Pathology, College of Veterinary Medicine, Washington State University, Pullman, WA 99164, USA
    Virology 306:116-25. 2003
    ..Goats receiving prime-boost vaccination with CAEV env plasmids and SU-FIA became infected but suppressed postchallenge virus replication, provirus loads in lymph node, and development of arthritis for at least 84 weeks...
  24. ncbi An epidemic of caprine arthritis encephalitis in Japan: isolation of the virus
    Misako Konishi
    National Institute of Animal Health, Tsukuba, Ibaraki, Japan
    J Vet Med Sci 66:911-7. 2004
    ..Goats inoculated with the culture fluid became antibody positive. These results suggested that a CAEV-infected goat had been introduced accidentally to the farm and that subclinical infection occurred among the flock...
  25. ncbi Usefulness of estimated surface area of damaged skin as a proxy of mite load in the monitoring of sarcoptic mange in free-ranging populations of Iberian wild goat, Capra pyrenaica
    Jesús M Pérez
    Departamento de Biologia Animal, Biología Vegetal y Ecología, Universidad de Jaen, Campus Las Lagunillas, S N, E 23071 Jaén, Spain
    Vet Parasitol 176:258-64. 2011
    ..Therefore, we conclude that revised classifications should be used in the monitoring of sarcoptic mange in wild populations, since data can be obtained in an inexpensive, fast and non-invasive fashion...
  26. pmc Resistance to classical scrapie in experimentally challenged goats carrying mutation K222 of the prion protein gene
    Pier Luigi Acutis
    CEA, Italian Reference Laboratory for TSEs, Neuroscienze Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d Aosta, Via Bologna 148, 10154 Torino, Italy
    Vet Res 43:8. 2012
    ....
  27. ncbi In vitro properties of small ruminant lentivirus genotype E
    M Juganaru
    Dipartimento di Produzioni Animali, Epidemiologia ed Ecologia, Universita di Torino, Italy
    Virology 410:88-95. 2011
    ....
  28. ncbi Occurrence, quantification, and genotyping of Mycoplasma conjunctivae in wild Caprinae with and without infectious keratoconjunctivitis
    Fabien Mavrot
    Centre for Fish and Wildlife Health, Vetsuisse Faculty, University of Bern, Langgass strasse 122, Postfach 8466, CH 3001 Bern, Switzerland
    J Wildl Dis 48:619-31. 2012
    ..We propose that individual or environmental factors influence the clinical expression of the disease and that persistence of M. conjunctivae in populations of wild Caprinae cannot be excluded...
  29. ncbi Diagnostic performance of ELISA and PCR in identifying SRLV-infected sheep and goats using serum, plasma and milk samples and in early detection of infection in dairy flocks through bulk milk testing
    J M A Brinkhof
    Department for Diagnostics, Research and Epidemiology, Animal Health Service Deventer, Deventer, The Netherlands
    Vet Microbiol 142:193-8. 2010
    ..These results demonstrate the potential of bulk milk testing as a cost effective tool for early detection of infection in dairy flocks, which is essential for SRLV-monitoring programs...
  30. ncbi Molecular characterization of lentiviruses from goats from Poland based on gag gene sequence analysis
    Jacek Kuzmak
    Department of Biochemistry, National Veterinary Research Institute, 24 100 Pulawy, Poland
    Comp Immunol Microbiol Infect Dis 30:211-23. 2007
    ..This might indicate a recent cross-species infection from sheep to goat...
  31. ncbi Matrix protein and glycoproteins F and H of Peste-des-petits-ruminants virus function better as a homologous complex
    M Mahapatra
    Institute for Animal Health, Pirbright, Woking, Surrey GU24 0NF, UK
    J Gen Virol 87:2021-9. 2006
    ..The neutralizing-antibody titre on the day of challenge was approximately 17 times higher than that in the RPV-PPRFH group, indicating RPV-PPRMFH as a promising marker-vaccine candidate...
  32. ncbi Plasmid DNA encoding caprine interferon gamma inhibits antibody response to caprine arthritis-encephalitis virus (CAEV) surface protein encoded by a co-administered plasmid expressing CAEV env and tat genes
    W P Cheevers
    Department of Veterinary Microbiology and Pathology, Washington State University, 99164 7040, Pullman, WA, USA
    Vaccine 19:3209-15. 2001
    ..Results indicate that synergistic effects of CAEV Tat and IFNgamma suppress the primary adaptive B cell response to plasmid encoded SU...
  33. ncbi Immune responses in goats to recombinant hemagglutinin-neuraminidase glycoprotein of Peste des petits ruminants virus: identification of a T cell determinant
    G Sinnathamby
    Department of Microbiology and Cell Biology, Indian Institute of Science, 560 012, Bangalore, India
    Vaccine 19:4816-23. 2001
    ....
  34. ncbi The detection of antibody against peste des petits ruminants virus in sheep, goats, cattle and buffaloes
    Haider Ali Khan
    Department of Veterinary Microbiology, Faculty of Veterinary Science, University of Agriculture, Street No 2, Khalsa College, Faisalabad, Pakistan
    Trop Anim Health Prod 40:521-7. 2008
    ....
  35. ncbi Leptospirosis as the most frequent infectious disease impairing productivity in small ruminants in Rio de Janeiro, Brazil
    Gabriel Martins
    Veterinary Bacteriology Laboratory, Universidade Federal Fluminense, Niteroi, RJ 24210 130, Brazil
    Trop Anim Health Prod 44:773-7. 2012
    ..6% of goats and 3.2% of sheep samples were positive for CAE and MV, respectively. Leptospirosis was the major infectious problem in the small ruminants sampled and may contribute to impaired productivity of these animals...
  36. ncbi Development of one-step real-time RT-PCR assay for detection and quantitation of peste des petits ruminants virus
    Jingyue Bao
    China Animal Health and Epidemiology Center, Qingdao, Shandong 266032, China
    J Virol Methods 148:232-6. 2008
    ..7% to 73.3% by use of the real-time qRT-PCR. The real-time qRT-PCR assay described in this report allows the rapid, specific and sensitive laboratory detection of PPRV in tissue samples from field cases...
  37. ncbi Early detection of viral excretion from experimentally infected goats with peste-des-petits ruminants virus
    E Couacy-Hymann
    LANADA Laboratoire Central de Pathologie Animale de Bingerville, Cote d Ivoire
    Prev Vet Med 78:85-8. 2007
    ..This experiment indicates that incubatory carriers therefore might play a role in the transmission of PPRV among small ruminants...
  38. pmc Direct evidence for natural transmission of small-ruminant lentiviruses of subtype A4 from goats to sheep and vice versa
    Cyril Shah
    Swiss National Center for Retroviruses, University of Zurich, Zurich, Switzerland
    J Virol 78:7518-22. 2004
    ..These findings present for the first time direct evidence that natural interspecies transmission of SRLV is ongoing in both directions. The findings are of relevance to virus eradication programs in both species...
  39. ncbi Outbreak of tuberculosis caused by Mycobacterium bovis in golden Guernsey goats in Great Britain
    R Daniel
    Veterinary Laboratories Agency VLA Carmarthen, Job s Well Road, Johnstown, Carmarthen SA31 3EZ
    Vet Rec 165:335-42. 2009
    ..There was a perfect correlation between the SICCT test and culture results in all slaughtered goats. Grossly visible tubercular lesions were observed at postmortem examination in all but one reactor...
  40. ncbi First-time detection of mycobacterium species from goats in Ethiopia
    Adem Hiko
    Faculty of Veterinary Medicine, Department of Epidemiology, Microbiology and Veterinary Public Health, Haramaya University, Haramaya, Ethiopia
    Trop Anim Health Prod 43:133-9. 2011
    ..To the best of our knowledge, this is the first report of caprine tuberculosis from Ethiopia. Further studies are required at the farm level to determine the prevalence of tuberculosis in the general goat population...
  41. ncbi Tissue tropism and promoter sequence variation in caprine arthritis encephalitis virus infected goats
    B Murphy
    Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California, Davis, CA 95616 USA
    Virus Res 151:177-84. 2010
    ..These results therefore do not provide evidence for the study hypothesis. However, multiple motifs within the U3 promoter region were highly conserved both within the entire collection of sequences and within tissue-specific groups...
  42. ncbi The virus causing encephalomyelitis in sheep in Spain: a new member of the tick-borne encephalitis group
    M S Marin
    Institute of Virology and Environmental Microbiology, Edinburgh
    Res Vet Sci 58:11-3. 1995
    ..It is concluded that the cause of sheep encephalomyelitis in Spain is a distinct species in the tick-borne encephalitis virus group...
  43. ncbi Caprine PRNP polymorphisms at codons 171, 211, 222 and 240 in a Greek herd and their association with classical scrapie
    Ilias G Bouzalas
    Laboratory of Microbiology and Infectious Diseases, Faculty of Veterinary Medicine, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece
    J Gen Virol 91:1629-34. 2010
    ..Resistant alleles that include K(222) and Q(211) are absent or rare in sheep and can provide the basis for the development of a feasible breeding programme for scrapie eradication in goats...
  44. pmc Peste des petits ruminants virus in Tibet, China
    Zhiliang Wang
    China Animal Health and Epidemiology Center, Qingdao, People s Republic of China
    Emerg Infect Dis 15:299-301. 2009
    ..Phylogenetic analysis confirms that the PPRV strain from Tibet is classified as lineage 4 and is closely related to viruses currently circulating in neighboring countries of southern Asia...
  45. ncbi Prevalence and distribution of peste des petits ruminants virus infection in small ruminants in India
    R P Singh
    Indian Veterinary Research Institute, Izatnagar, Bareilly UP 243122, India
    Rev Sci Tech 23:807-19. 2004
    ..These findings may be correlated with variations in the sheep and goat husbandry practices within different geographic regions, the topography of different states and the socio-economic status of individual Indian farmers...
  46. pmc Reduction of Coxiella burnetii prevalence by vaccination of goats and sheep, The Netherlands
    Lenny Hogerwerf
    Department of Farm Animal Health, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands
    Emerg Infect Dis 17:379-86. 2011
    ..These effects were most pronounced in animals during their first pregnancy. Results indicate that vaccination may reduce bacterial load in the environment and human exposure to C. burnetii...
  47. ncbi Goats may experience reproductive failures and shed Coxiella burnetii at two successive parturitions after a Q fever infection
    M Berri
    INRA Tours Nouzilly, Infectiologie Animale et Sante Publique, 37380 Nouzilly, France
    Res Vet Sci 83:47-52. 2007
    ..Furthermore, the bacteria were found into 14 vaginal swabs and 12 milk samples taken from infected females at both kidding seasons...
  48. pmc Coxiella burnetii shedding routes and antibody response after outbreaks of Q fever-induced abortion in dairy goat herds
    Elodie Rousset
    Agence Française de Sécurité Sanitaire des Aliments French Food Safety Agency AFSSA, Unité Pathologie des Ruminants Laboratory of Pathologies in Ruminants, Sophia Antipolis, France
    Appl Environ Microbiol 75:428-33. 2009
    ..Two opposite shedding trends were thus apparent for the milk and vaginal-fecal routes. Moreover, this study showed that a nonnegligible proportion of seronegative animals that delivered normally could excrete C. burnetii...
  49. ncbi Spatial risk assessment of Rift Valley fever in Senegal
    Archie C A Clements
    Epidemiology Division, Department of Veterinary Clinical Sciences, Royal Veterinary College, Hatfield, Hertfordshire, United Kingdom
    Vector Borne Zoonotic Dis 7:203-16. 2007
    ..These risk maps are suitable for use in planning improved sentinel surveillance systems in Senegal, although further data collection is required in large areas of Senegal to better define the spatial distribution of RVF...
  50. ncbi Q Fever in dairy animals
    Annie Rodolakis
    INRA, UR 1282 Infectiologie Animale et Santé Publique, F 37380 Nouzilly
    Ann N Y Acad Sci 1166:90-3. 2009
    ..The number of Coxiella shed in milk is generally low. The phase I vaccine prevented abortion and greatly decreased the shedding of C. burnetii in milk...
  51. ncbi Capripoxviruses: an emerging worldwide threat to sheep, goats and cattle
    S Babiuk
    National Centre for Foreign Animal Disease, Winnipeg MB, Canada
    Transbound Emerg Dis 55:263-72. 2008
    ..Capripoxviruses have the potential to become emerging disease threats because of global climate change and changes in patterns of trade in animals and animal products. They also could be used as economic bioterrorism agents...
  52. pmc Characterization of Mycobacterium caprae isolates from Europe by mycobacterial interspersed repetitive unit genotyping
    Wolfgang M Prodinger
    Department of Hygiene, Microbiology, and Social Medicine, Innsbruck Medical University, Fritz Pregl Strasse 3, A 6020 Innsbruck, Austria
    J Clin Microbiol 43:4984-92. 2005
    ..tuberculosis. The analysis did not reflect geographic patterns indicative of origin or spread of M. caprae. Altogether, our data confirm M. caprae as a distinct phylogenetic lineage within the Mycobacterium tuberculosis complex...
  53. ncbi Identification of seven haplotypes of the caprine PrP gene at codons 127, 142, 154, 211, 222 and 240 in French Alpine and Saanen breeds and their association with classical scrapie
    F Barillet
    INRA, UR 631, Station d Amélioration Génétique des Animaux, BP 52627, 31326 Castanet Tolosan Cedex, France
    J Gen Virol 90:769-76. 2009
    ..However, mutated allele frequencies in French Alpine and Saanen breeds were low (0.5-18.5 %), which prevent us from assessing the influence of all the possible genotypes in natural exposure conditions...
  54. ncbi Identification of prion protein gene polymorphisms in goats from Italian scrapie outbreaks
    P L Acutis
    CEA Centro di referenza per le Encefalopatie Animali, Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d Aosta, Via Bologna 148, 10154 Turin, Italy
    J Gen Virol 87:1029-33. 2006
    ..Twelve alleles were determined by cloning. Statistical analysis suggested a possible protective role against scrapie for the glutamine to lysine mutation at codon 222...
  55. ncbi Evidence for persistent Bovine viral diarrhea virus infection in a captive mountain goat (Oreamnos americanus)
    Danielle D Nelson
    Washington Animal Disease Diagnostic Laboratory, College Station, Pullman, WA 99165 2037, USA
    J Vet Diagn Invest 20:752-9. 2008
    ..These findings provide evidence of persistent infection in a mountain goat, underscoring the need for pestivirus control strategies for wild ruminants in zoological collections...
  56. ncbi Serological evidence for BVDV-1 infection in goats in Poland - short communication
    Michał Czopowicz
    Warsaw University of Life Sciences, Department of Large Animal Diseases with the Clinic, Nowoursynowska, Warsaw, Poland
    Acta Vet Hung 59:399-404. 2011
    ..This is the first report on the diagnosis of BVDV-1 infection in Polish goats...
  57. ncbi Differentiation of sheep pox and goat poxviruses by sequence analysis and PCR-RFLP of P32 gene
    Madhusudan Hosamani
    Pox virus Laboratory, Division of Virology, Indian Veterinary Research Institute, Mukteswar 263 138, Nainital, Uttaranchal State
    Virus Genes 29:73-80. 2004
    ..Using this information, a PCR-RFLP method has been developed for unequivocal genomic differentiation of SPV and GPV...
  58. ncbi Detection of Coxiella burnetii, the agent of Q fever, in oviducts and uterine flushing media and in genital tract tissues of the non pregnant goat
    Ashraf Alsaleh
    LUNAM University, ONIRIS, Nantes Atlantic National College of Veterinary Medicine, Food Science and Engineering, Department of Research into the Health Risk and Biotechnology of Reproduction, Nantes, France
    Comp Immunol Microbiol Infect Dis 34:355-60. 2011
    ..The infection of genital tract flushing media and tissues is a risk factor for the transmission of C. burnetii from donor to recipient during embryo transfer or to the embryo and fetus when gestation is pursued to term...
  59. pmc Prevalence, distribution, and host range of Peste des petits ruminants virus, Turkey
    Aykut Ozkul
    Ankara University, Turkey
    Emerg Infect Dis 8:708-12. 2002
    ..4% and 6.28%, respectively. Two PPRVs of lineage 4, which comprises many other PPRVs whose origins are in the Middle East, the Arabian Peninsula, and southern Asia, were isolated from Turkish sheep...
  60. ncbi Development of a loop-mediated isothermal amplification method for rapid detection of caprine arthritis-encephalitis virus proviral DNA
    Jinhai Huang
    School of Chemical Engineering and Technology, Tianjin University, Nankai District, Tianjin 300072, China
    Arch Virol 157:1463-9. 2012
    ..Furthermore, the LAMP assay can be performed in less-well-equipped laboratories as well as in the field...
  61. ncbi Bovine viral diarrhea virus abortion in goats housed with persistently infected cattle
    C C Broaddus
    Department of Clinical Sciences, Center for Veterinary Health Sciences, Oklahoma State University, Stillwater, OK 74076, USA
    Vet Pathol 46:45-53. 2009
    ..As supported by the findings in this case, BVDV-2a should be included as a differential for abortion in goats. This is the first report of abortion in goats after exposure to persistently infected cattle...
  62. ncbi Phylogenetic analysis of small ruminant lentiviruses detected in Slovenia
    Urška Kuhar
    University of Ljubljana, Veterinary Faculty, Gerbiceva 60, SI 1115 Ljubljana, Slovenia
    Vet Microbiol 162:201-6. 2013
    ..We propose two new subtypes within genotype A, subtype A14 (SLO 2) and A15 (SLO 31)...
  63. ncbi Staphylococcus aureus subsp. anaerobius isolates from different countries are clonal in nature
    Ricardo de la Fuente
    Departamento de Sanidad Animal, Facultad de Veterinaria, Universidad Complutense de Madrid, Avda Puerta de Hierro s n, 28040 Madrid, Spain
    Vet Microbiol 150:198-202. 2011
    ..Our results support the view that abscess disease is caused by a single bacterial clone worldwide. This bacterium has existed for at least a century and, thus, has undergone long-term small ruminant host restriction...
  64. pmc The genomes of sheeppox and goatpox viruses
    E R Tulman
    Plum Island Animal Disease Center, Agricultural Research Service, U S Department of Agriculture, Greenport, New York 11944, USA
    J Virol 76:6054-61. 2002
    ..These comparative genomic data indicate the close genetic relationship among capripoxviruses, and they suggest that SPPV and GTPV are distinct and likely derived from an LSDV-like ancestor...
  65. ncbi Protection of goats against peste des petits ruminants with recombinant capripoxviruses expressing the fusion and haemagglutinin protein genes of rinderpest virus
    C H Romero
    BBSRC Institute for Animal Health, Pirbright Laboratory, Woking, Surrey, UK
    Vaccine 13:36-40. 1995
    ..A similar response to the two recombinant vaccines has previously been reported for cattle. Neither recombinant produced detectable levels of specific antibodies to PPR virus...
  66. ncbi Natural infection with peste des petits ruminants virus: a pre and post vaccinal assessment following an outbreak scenario
    Muhammad Abubakar
    PARC Institute of Advance Studies in Agriculture, National Agriculture Research Center, Park Road, Islamabad, Pakistan
    Virus Res 167:43-7. 2012
    ....
  67. ncbi Specific detection of small ruminant lentiviral nucleic acid sequences located in the proviral long terminal repeat and leader-gag regions using real-time polymerase chain reaction
    J M A Brinkhof
    Animal Health Service Ltd, Arnsbergstraat 7, Deventer, The Netherlands
    J Virol Methods 147:338-44. 2008
    ..Real-time PCR testing, especially the application of oligonucleotides for priming the leader-gag region appeared promising in detecting SRLV specific proviral DNA in blood samples from both sheep and goats...
  68. ncbi Effect of an inactivated paratuberculosis vaccine on the intradermal testing of goats for tuberculosis
    Christophe Chartier
    ONIRIS, UMR 1300 Bio Agression, Epidémiologie et Analyse de Risque en santé animale, 44307 Nantes, France
    Vet J 191:360-3. 2012
    ..The study findings demonstrate that the use of an inactivated paratuberculosis vaccine in goats <1 month-old in a TB-free herd does not result in false positives to a CID test for TB when performed in animals ≥20 months-old...
  69. ncbi Prevalence and molecular characterisation of Cryptosporidium and Giardia in lambs and goat kids in Belgium
    Thomas Geurden
    Laboratory of Parasitology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B 9820 Merelbeke, Belgium
    Vet Parasitol 155:142-5. 2008
    ....
  70. ncbi Immunological parameters in goats experimentally infected with SRLV genotype E, strain Roccaverano
    Ramses Reina
    Instituto de Agrobiotecnologia, CSIC Universidad Pública de Navarra Gobierno de Navarra, Mutilva Baja, Navarra, Spain
    Vet Immunol Immunopathol 139:237-44. 2011
    ..This is the first study reporting experimentally induced immunological changes in SRLV genotype E infection and indicates that CTL activity may be the adaptive immune response able to induce protection against heterologous infection...
  71. ncbi First report of Mycoplasma conjunctivae from wild Caprinae with infectious keratoconjunctivitis in the Pyrenees (NE Spain)
    Ignasi Marco
    Servei d Ecopatologia de Fauna Salvatge, Facultat de Veterinaria, Universitat Autonoma de Barcelona, 08193 Bellaterra, Barcelona, Spain
    J Wildl Dis 45:238-41. 2009
    ..This is the first report of M. conjunctivae in Pyrenean chamois, and it supports the hypothesis that M. conjunctivae also could be the main cause of infectious keratoconjunctivitis in areas other than the Alps, such as the Pyrenees...
  72. ncbi Evidence of peste des petits ruminants virus (PPRV) infection in Sindh Ibex (Capra aegagrus blythi) in Pakistan as confirmed by detection of antigen and antibody
    Muhammad Abubakar
    National Veterinary Laboratory, Park Road, Islamabad, Pakistan
    Trop Anim Health Prod 43:745-7. 2011
    ..The disease threatened the huge population of ibex in the wild life park, which was spread over a large area, but vaccination of the domestic population of sheep and goats in the surrounding villages appeared to control the disease...
  73. ncbi Benefits of urea-molasses block supplementation and symptomatic and tactical anthelmintic treatments of communally grazed indigenous goats in the Bulwer area, Kwazulu-Natal Province, South Africa
    A F Vatta
    Onderstepoort Veterinary Institute, Private Bag X05, Onderstepoort, 0110, South Africa
    J S Afr Vet Assoc 78:81-9. 2007
    ..It is considered that the routine symptomatic treatment of anaemic goats may have been a key factor. More detailed investigations into the routine symptomatic treatment of anaemic goats are therefore recommended...
  74. ncbi Application of PCR technique in diagnosis of small ruminant lentivirus infection in sheep and goats
    A Gil
    Department of Biochemistry, National Veterinary Research Institute, al Partyzantow 57, 24 100 Pulawy, Poland
    Pol J Vet Sci 9:213-7. 2006
    ..In conclusion, the data demonstrated that combinations of both ELISA and PCR might afford optimal detection of SRLVs infection...
  75. ncbi Multiple anthelmintic resistance and the possible contributory factors in Beetal goats in an irrigated area (Pakistan)
    Muhammad Saeed
    Department of Parasitology, University of Agriculture, Faisalabad 38040, Pakistan
    Res Vet Sci 88:267-72. 2010
    ..Step-wise logistic regression of the data on worm control practices revealed significant role of under-dosing, low-protein diets, healthcare supervision by the traditional healers and mass treatments...
  76. ncbi Granulomatous encephalitis in a neurologically impaired goat kid associated with degeneration of Neospora caninum tissue cysts
    L G Corbellini
    Department of Pathology, Veterinary Faculty, Universidade Federal do Rio Grande do Sul, RS, Brazil
    J Vet Diagn Invest 13:416-9. 2001
    ..caninum and the presence of granulomatous inflammation with rare giant cells associated with degeneration of tissue cysts...
  77. ncbi Testing for clinical anaemia caused by Haemonchus spp. in goats farmed under resource-poor conditions in South Africa using an eye colour chart developed for sheep
    A F Vatta
    Onderstepoort Veterinary Institute, Private Bag X05, 0110, Onderstepoort, South Africa
    Vet Parasitol 99:1-14. 2001
    ..The validation of the FAMACHA system for goats for use by resource-poor farmers, which this paper describes, may have wide application in the tropics and subtropics of sub-Saharan Africa and elsewhere...
  78. ncbi Serological study of contagious agalactia in herds of goats in the Canary Islands
    P Assunção
    Unit of Epidemiology and Preventive Medicine, Veterinary Faculty, University of Las Palmas, Transmontaña s n 35416 Arucas, Las Palmas de Gran Canaria, Spain
    Vet Rec 154:684-7. 2004
    ..The results indicated that the seroprevalence of both organisms is high on all the islands; average values of 55 per cent and 67 per cent were recorded, respectively, for M agalactiae and MmmLC...
  79. ncbi Outbreak of Q fever associated with a horse-boarding ranch, Colorado, 2005
    Wendy M Bamberg
    Epidemic Intelligence Service, Colorado Department of Public Health and Environment, Centers for Disease Control and Prevention, Atlanta, GA, USA
    Vector Borne Zoonotic Dis 7:394-402. 2007
    ..This is the first time an IS1111 PCR assay has been used in an outbreak investigation in the United States...
  80. ncbi A classical inactivated vaccine induces protection against caprine herpesvirus 1 infection in goats
    M Tempesta
    Department of Health and Animal Well being, Faculty of Veterinary Medicine, University of Bari, Strada per Casamassima Km 3, 70010 Valenzano, Italy
    Vaccine 19:3860-4. 2001
    ..Protection against infection depended on the number of injections of vaccine and the route of challenge...
  81. ncbi A preliminary study on the pathogenicity of a strain of caprine herpesvirus-1
    M Tempesta
    Department of Health and Animal Welfare, Faculty of Veterinary Medicine, University of Bari, Valenzano, Italy
    Comp Immunol Microbiol Infect Dis 22:137-43. 1999
    ..All isolates from the experimental goats were identical in their restriction patterns to the original BA-1 and were similar to the reference E/CH strains of CpHV-1...
  82. pmc Seroepidemiological study of Q fever in domestic ruminants in semi-extensive grazing systems
    Francisco Ruiz-Fons
    NEIKER Instituto Vasco de Investigación y Desarrollo Agrario, Department of Animal Health, Bizkaia, Spain
    BMC Vet Res 6:3. 2010
    ..Serum antibodies were analysed by ELISA and positive samples were retested by Complement Fixation test (CFT) to detect recent infections...
  83. ncbi Presence of caprine arthritis-encephalitis virus (CAEV) proviral DNA in genital tract tissues of superovulated dairy goat does
    F Fieni
    Department of Population Health and Reproduction, University of California, Davis 95616, USA
    Theriogenology 59:1515-23. 2003
    ..01). This study demonstrated the presence of CAEV-infected cells in the goat genital tract. The presence of CAEV-infected cells in the uterus and oviducts suggests potential for vertical transmission of CAEV from doe to embryo or fetus...
  84. ncbi Domestic animals as potential reservoir hosts of Trypanosoma brucei gambiense in sleeping sickness foci in Cameroon
    F Njiokou
    General Biology Laboratory, Department of Biology and Animal Physiology, Faculty of Science, BP 812, University of Yaounde 1, Yaounde, Cameroon
    Parasite 17:61-6. 2010
    ..92%) animals from Bipindi, 15 (4.83%) from Campo, 4 (2.59%) from FontemCenter and none from Doumé. The infection rates significantly differed between the localities, and correlated with the intensity of HAT transmission in the foci...
  85. ncbi Elimination of small ruminant lentivirus infection from sheep flocks and goat herds aided by health schemes in Great Britain
    B A Synge
    Mill Grange, Ballinglen, Tinahely, County Wicklow, Ireland
    Vet Rec 167:739-43. 2010
    ..A strategy was devised to interpret the ELISA results depending upon the prevalence of infection at the time. Eighteen of the 33 flocks/herds (54.5 per cent) that had introductions of infection also owned non-accredited stock...
  86. ncbi Risk factors associated with Mycoplasma agalactiae infection of small ruminants in northern Jordan
    Waleed Al-Momani
    University of Nizwa, Barkat Al Mauz, Nizwa, Oman
    Prev Vet Med 83:1-10. 2008
    ..04) with M. agalactiae seropositivity. Educating small ruminant farmers to avoid the use of outsider rams, ensuring adequate cleaning of milking utensils and separating the young from dams would enhance the health of small ruminants...
  87. ncbi Experimental Coxiella burnetii infection in pregnant goats: a histopathological and immunohistochemical study
    J Sanchez
    Departamento de Anatomia y Anatomia Patologica Comparadas, Universidad de Murcia, Campus de Espinardo, 30100 Murcia, Spain
    J Comp Pathol 135:108-15. 2006
    ..Neither lesions nor C. burnetii DNA were found in maternal organs in animals maintained until day 120 post-abortion...
  88. ncbi Efficacy of copper oxide wire particles against gastrointestinal nematodes in sheep and goats
    F Soli
    Fort Valley State University, Fort Valley, GA 31030, USA
    Vet Parasitol 168:93-6. 2010
    ..In this study, COWP treatment was equally effective against H. contortus infection in lambs and kids and appears to be an effective method of controlling H. contortus infection for up to 6 weeks in small ruminants following weaning...
  89. ncbi Microbiological survey for Mycoplasma spp. in a contagious agalactia endemic area
    C de la Fe
    Unit of Epidemiology and Preventive Medicine, Veterinary Faculty, University of Las Palmas, Trasmontaña s n 35416 Arucas, Gran Canaria, Spain
    Vet J 170:257-9. 2005
    ....
  90. ncbi Proviral DNA of caprine arthritis encephalitis virus (CAEV) is detected in cumulus oophorus cells but not in oocytes from naturally infected goats
    M Z Ali Al Ahmad
    Department of Research into the Health Risks and Biotechnology of Reproduction ENVN DGER, National Veterinary School, BP 40706, 44307 Nantes Cedex 03, France
    Theriogenology 64:1656-66. 2005
    ....
  91. pmc Detection of Coxiella burnetii DNA on small-ruminant farms during a Q fever outbreak in the Netherlands
    A de Bruin
    National Institute for Public Health and the Environment RIVM, Centre for Infectious Disease Control CIb, Bilthoven, Netherlands
    Appl Environ Microbiol 78:1652-7. 2012
    ..burnetii to humans...
  92. ncbi Evaluation of specificity of tuberculosis diagnostic assays in caprine flocks under different epidemiological situations
    Javier Bezos
    Centro VISAVET, Universidad Complutense de Madid, 28040 Madrid, Spain
    Res Vet Sci 93:636-40. 2012
    ..However, certain factors such as C. pseudotuberculosis infection and paratuberculosis vaccination can have a negative impact in the most sensitive tests...
  93. ncbi Extended surveillance for CBPP in a free country: Challenges and solutions regarding the potential caprine reservoir
    Florence Tardy
    Anses, Lyon Laboratory, UMR Mycoplasmoses of Ruminants, 31 Avenue Tony Garnier F 69364 Lyon cedex 07, France
    Prev Vet Med 101:89-95. 2011
    ..In conclusion, the commercially available cELISA can be considered specific enough to be used as a primary test to monitor passage of the CBPP agent in goats, but its sensitivity in goats requires further investigation...
  94. ncbi Pestivirus infection in sheep and goats in West Austria
    R Krametter-Froetscher
    Clinic for Ruminants, Department for Farm Animals and Veterinary Public Health, University of Veterinary Medicine, Veterinaerplatz 1, A 1210 Vienna, Austria
    Vet J 186:342-6. 2010
    ..The results underline the need for the immediate consideration of small ruminants in eradication programmes...
  95. pmc Experimental model of tuberculosis in the domestic goat after endobronchial infection with Mycobacterium caprae
    Bernat de Val Pérez
    Centre de Recerca en Sanitat Animal, UAB IRTA, Campus de la Universitat Autonoma de Barcelona, 08193 Bellaterra, Catalonia, Spain
    Clin Vaccine Immunol 18:1872-81. 2011
    ..bovis over a similar period of time. The present work proposes a reliable new experimental animal model for a better understanding of caprine tuberculosis and future development of vaccine trials in this and other species...
  96. pmc The potential to control Haemonchus contortus in indigenous South African goats with copper oxide wire particles
    A F Vatta
    Onderstepoort Veterinary Institute, Onderstepoort 0110, South Africa
    Vet Parasitol 162:306-13. 2009
    ..contortus infections in indigenous South African goats, but their use as part of an integrated approach to control H. contortus in the field must be fully investigated...
  97. ncbi Natural peste des petits ruminants virus infection: novel pathologic findings resembling other morbillivirus infections
    O Kul
    Department of Pathology, Kirikkale University, Faculty of Veterinary Medicine, 71451, Yahsihan, Kirikkale, Turkey
    Vet Pathol 44:479-86. 2007
    ..7 %). Phylogenetic analysis showed that viruses belong to lineage 4 in the peste des petits ruminants virus common phylogenetic tree...
  98. ncbi Assessment of genetic variability of resistance to gastrointestinal nematode parasites in Creole goats in the humid tropics
    N Mandonnet
    Institut National de la Recherche Agronomique, Station de Recherches Zootechniques, Domaine Duclos, Guadeloupe, French West Indies
    J Anim Sci 79:1706-12. 2001
    ..Genetic correlations between packed cell volume and live weight decreased from 0.47 to 0.10 from weaning to 10 mo of age. These results demonstrated the feasibility of breeding for improved resistance to nematodes in Creole kids...
  99. ncbi Phylogenetic analysis of small-ruminant lentivirus subtype B1 in mixed flocks: evidence for natural transmission from goats to sheep
    Giuliano Pisoni
    Department of Animal Pathology, Hygiene and Veterinary Public Health, University of Milano, Via Celoria 10, 20133 Milano, Italy
    Virology 339:147-52. 2005
    ..This implies that SRLV control programs targeting only sheep or goats can no longer be proposed (based on a putative species specificity of the SRLV subtype B1)...
  100. ncbi Histidine at codon 154 of the prion protein gene is a risk factor for Nor98 scrapie in goats
    Silvia Colussi
    Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d Aosta, Via Bologna 148, Torino, Italy
    J Gen Virol 89:3173-6. 2008
    ..The results revealed that histidine at codon 154 is also strongly associated with the disease in goats...
  101. ncbi Mycoplasma mycoides subsp. mycoides biotype large colony isolates from healthy and diseased goats: prevalence and typing
    F Tardy
    UMR AFSSA ENVL Mycoplasmoses des Ruminants, Agence Francaise de Securite Sanitaire des Aliments, Site de Lyon, 31 avenue Tony Garnier, 69364 Lyon Cedex 07, France
    Vet Microbiol 121:268-77. 2007
    ..Whether this reflects differences in virulence between different field strains of MmmLC remains to be demonstrated...

Research Grants6

  1. IMMUNE CONTROL OF CAE LENTIVIRUS
    Donald Knowles; Fiscal Year: 2005
    ..Therefore, the second objective of this proposal is to evaluate virus replication following CAEV challenge of goats co-immunized with plasmid DNA expressing CAEV env and tat genes and caprine IFN. ..
  2. TRICHINELLOSIS AND REGULATION OF HOST GENE EXPRESSION
    Douglas Jasmer; Fiscal Year: 2001
    ..Understanding these mechanisms may also contribute unique insight on mechanisms of muscle differentiation and cell cycle regulation in mammalian cells. ..
  3. Novel Integrative Genetic Elements of Mycoplasmas
    Michael Calcutt; Fiscal Year: 2003
    ....
  4. GTPase Activating Proteins in Aging and Osteoarthritis
    Lisa Fortier; Fiscal Year: 2007
    ..We anticipate that these findings will facilitate identification of target molecules for development of therapeutics modalities for OA. [unreadable] [unreadable] [unreadable]..
  5. Spiroplasma 16S rDNA in TSE Brain Tissues
    Frank Bastian; Fiscal Year: 2006
    ..involved. Although the role of Spiroplasma in TSE cannot be determined from these experiments, the presence of this microbe in all cases of TSE and not in controls would provide the basis for developing a test for TSE ..
  6. Antigenic variation in rickettsial transmission
    Guy Palmer; Fiscal Year: 2008
    ..This hypothesis will be addressed using comprehensive identification of the variant population in the reservoir host and tick vector and testing whether immune responses against a broad array of variants prevents superinfection. ..