fish diseases

Summary

Summary: Diseases of freshwater, marine, hatchery or aquarium fish. This term includes diseases of both teleosts (true fish) and elasmobranchs (sharks, rays and skates).

Top Publications

  1. ncbi Fish-borne parasitic zoonoses: status and issues
    Jong Yil Chai
    Department of Parasitology and Tropical Medicine, Seoul National University College of Medicine, and Institute of Endemic Diseases, Seoul National University Medical Research Center, Seoul 110 799, South Korea
    Int J Parasitol 35:1233-54. 2005
  2. pmc Expression and functional characterization of the RIG-I-like receptors MDA5 and LGP2 in Rainbow trout (Oncorhynchus mykiss)
    Mingxian Chang
    State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China
    J Virol 85:8403-12. 2011
  3. ncbi Immunogenic and protective effects of an oral DNA vaccine against infectious pancreatic necrosis virus in fish
    Ana I de Las Heras
    Centro de Investigaciones Biologicas, Departamento de Microbiología Molecular y Biología de las Infecciones, C Ramiro de Maeztu 9, 28040 Madrid, Spain
    Fish Shellfish Immunol 28:562-70. 2010
  4. pmc Emerging foodborne trematodiasis
    Jennifer Keiser
    Swiss Tropical Institute, Basel, Switzerland
    Emerg Infect Dis 11:1507-14. 2005
  5. pmc Mitochondrial antiviral signaling protein plays a major role in induction of the fish innate immune response against RNA and DNA viruses
    Stephane Biacchesi
    INRA, CRJ, Jouy en Josas, France
    J Virol 83:7815-27. 2009
  6. pmc Teleost fish mount complex clonal IgM and IgT responses in spleen upon systemic viral infection
    Rosario Castro
    Virologie et Immunologie Moléculaires, INRA, Jouy en Josas, France
    PLoS Pathog 9:e1003098. 2013
  7. ncbi Experimental evidence for direct in situ binding of IgM and IgT to early trophonts of Ichthyophthirius multifiliis (Fouquet) in the gills of rainbow trout, Oncorhynchus mykiss (Walbaum)
    L von Gersdorff Jørgensen
    Laboratory of Aquatic Pathobiology, Section of Biomedicine, Faculty of Life Sciences, University of Copenhagen, Frederiksberg C, Denmark
    J Fish Dis 34:749-55. 2011
  8. ncbi Cellular and humoral factors involved in the response of rainbow trout gills to Ichthyophthirius multifiliis infections: molecular and immunohistochemical studies
    Moonika M Olsen
    Laboratory of Aquatic Pathobiology, Department of Veterinary Disease Biology, Faculty of Life Sciences, University of Copenhagen, Stigbøjlen 7, DK 1870 Frederiksberg C, Denmark
    Fish Shellfish Immunol 30:859-69. 2011
  9. ncbi Early antiviral response and virus-induced genes in fish
    Eloi R Verrier
    INRA, Fish Infection and Immunity, Molecular Virology and Immunology, Domaine de Vilvert, 78352 Jouy en Josas, France
    Dev Comp Immunol 35:1204-14. 2011
  10. ncbi Control of puberty in farmed fish
    Geir Lasse Taranger
    Institute of Marine Research, PO Box 1870 Nordnes, 5817 Bergen, Norway
    Gen Comp Endocrinol 165:483-515. 2010

Detail Information

Publications372 found, 100 shown here

  1. ncbi Fish-borne parasitic zoonoses: status and issues
    Jong Yil Chai
    Department of Parasitology and Tropical Medicine, Seoul National University College of Medicine, and Institute of Endemic Diseases, Seoul National University Medical Research Center, Seoul 110 799, South Korea
    Int J Parasitol 35:1233-54. 2005
    ..The life cycles, distributions, epidemiology, clinical aspects, and, importantly, the research needed for improved risk assessments, clinical management and prevention and control of these important parasitic diseases are reviewed...
  2. pmc Expression and functional characterization of the RIG-I-like receptors MDA5 and LGP2 in Rainbow trout (Oncorhynchus mykiss)
    Mingxian Chang
    State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China
    J Virol 85:8403-12. 2011
    ..Interestingly, MDA5 expression was not affected by overexpressed LGP2 in transfected cells and vice versa, suggesting that they likely act in parallel as positive regulators for IFN production...
  3. ncbi Immunogenic and protective effects of an oral DNA vaccine against infectious pancreatic necrosis virus in fish
    Ana I de Las Heras
    Centro de Investigaciones Biologicas, Departamento de Microbiología Molecular y Biología de las Infecciones, C Ramiro de Maeztu 9, 28040 Madrid, Spain
    Fish Shellfish Immunol 28:562-70. 2010
    ..Thus, this study demonstrates the potential of the encapsulation technique for IPNV-DNA vaccine delivery and the relevance of the IPNV-VP2 gene for future plasmid constructs...
  4. pmc Emerging foodborne trematodiasis
    Jennifer Keiser
    Swiss Tropical Institute, Basel, Switzerland
    Emerg Infect Dis 11:1507-14. 2005
    ..This is supported by reviewing aquaculture development in countries endemic for foodborne trematodiasis over the past 10-50 years. Future and sustainable control of foodborne trematodiasis is discussed...
  5. pmc Mitochondrial antiviral signaling protein plays a major role in induction of the fish innate immune response against RNA and DNA viruses
    Stephane Biacchesi
    INRA, CRJ, Jouy en Josas, France
    J Virol 83:7815-27. 2009
    ..This report provides the first demonstration that teleost fish possess a functional RLR pathway in which MAVS may play a central role in the induction of the innate immune response...
  6. pmc Teleost fish mount complex clonal IgM and IgT responses in spleen upon systemic viral infection
    Rosario Castro
    Virologie et Immunologie Moléculaires, INRA, Jouy en Josas, France
    PLoS Pathog 9:e1003098. 2013
    ..Thus, it appears that the general properties of antibody responses were already in place in common ancestors of fish and mammals, and were globally conserved during evolution with possible functional convergences...
  7. ncbi Experimental evidence for direct in situ binding of IgM and IgT to early trophonts of Ichthyophthirius multifiliis (Fouquet) in the gills of rainbow trout, Oncorhynchus mykiss (Walbaum)
    L von Gersdorff Jørgensen
    Laboratory of Aquatic Pathobiology, Section of Biomedicine, Faculty of Life Sciences, University of Copenhagen, Frederiksberg C, Denmark
    J Fish Dis 34:749-55. 2011
    ..This study indicates that antibodies play an important part in the protection of immune fish against Ich although additional humoral and cellular factors may contribute to this reaction...
  8. ncbi Cellular and humoral factors involved in the response of rainbow trout gills to Ichthyophthirius multifiliis infections: molecular and immunohistochemical studies
    Moonika M Olsen
    Laboratory of Aquatic Pathobiology, Department of Veterinary Disease Biology, Faculty of Life Sciences, University of Copenhagen, Stigbøjlen 7, DK 1870 Frederiksberg C, Denmark
    Fish Shellfish Immunol 30:859-69. 2011
    ..multifiliis...
  9. ncbi Early antiviral response and virus-induced genes in fish
    Eloi R Verrier
    INRA, Fish Infection and Immunity, Molecular Virology and Immunology, Domaine de Vilvert, 78352 Jouy en Josas, France
    Dev Comp Immunol 35:1204-14. 2011
    ..Most of the ISG-based pathways remain to be directly determined in fish. Fish ISGs are often duplicated and the functional specialization of multigenic families will be of particular interest for future studies...
  10. ncbi Control of puberty in farmed fish
    Geir Lasse Taranger
    Institute of Marine Research, PO Box 1870 Nordnes, 5817 Bergen, Norway
    Gen Comp Endocrinol 165:483-515. 2010
    ..Further knowledge is needed on both basic and applied aspects of puberty control to refine existing methods and to develop new methods that are efficient in terms of production and acceptable in terms of fish welfare and sustainability...
  11. ncbi Dissection of a type VI secretion system in Edwardsiella tarda
    Jun Zheng
    Department of Biological Sciences, Faculty of Science, National University of Singapore, Singapore 117543
    Mol Microbiol 66:1192-206. 2007
    ..The interaction between EvpC and EvpP was demonstrated. Lastly, two proteins (EvpD and EvpJ) are not required for the T6SS-dependent secretion...
  12. ncbi Flavobacterium psychrophilum, invasion into and shedding by rainbow trout Oncorhynchus mykiss
    J Madetoja
    Institute of Parasitology, Department of Biology, Abo Akademi University, Finland
    Dis Aquat Organ 43:27-38. 2000
    ..In immunohistochemical examinations of organs and tissues of orally infected fish, F. psychrophilum cells were detected in only 1 fish out of 31 studied. Mortality of the orally challenged fish was not observed in the experiment...
  13. ncbi Iridovirus infections in finfish - critical review with emphasis on ranaviruses
    R J Whittington
    The University of Sydney, Australia
    J Fish Dis 33:95-122. 2010
    ....
  14. ncbi Innate host defense mechanisms of fish against viruses and bacteria
    A E Ellis
    FRS Marine Laboratory, PO Box 101, Victoria Road, Aberdeen AB11 9DB, Scotland, UK
    Dev Comp Immunol 25:827-39. 2001
    ....
  15. pmc Heart and skeletal muscle inflammation of farmed salmon is associated with infection with a novel reovirus
    Gustavo Palacios
    Center for Infection and Immunity, Columbia University, New York, New York, United States of America
    PLoS ONE 5:e11487. 2010
    ....
  16. ncbi Declining wild salmon populations in relation to parasites from farm salmon
    Martin Krkosek
    Centre for Mathematical Biology, Department of Mathematical and Statistical Sciences, University of Alberta, Edmonton, AB, Canada
    Science 318:1772-5. 2007
    ..These results suggest that salmon farms can cause parasite outbreaks that erode the capacity of a coastal ecosystem to support wild salmon populations...
  17. ncbi Comparison of vaccine efficacy for different antigen delivery systems for infectious pancreatic necrosis virus vaccines in Atlantic salmon (Salmo salar L.) in a cohabitation challenge model
    Hetron M Munang'andu
    Norwegian School of Veterinary Science, Department of Basic Sciences and Aquatic Medicine, Section of Aquatic Medicine and Nutrition, P O Box 8146 Dep, N 0033 Oslo, Norway
    Vaccine 30:4007-16. 2012
    ..Hence, there still remains the challenge of developing highly efficacious vaccines with the ability to eliminate the post challenge carrier state in IPNV vaccinology...
  18. pmc Cardiomyopathy syndrome of atlantic salmon (Salmo salar L.) is caused by a double-stranded RNA virus of the Totiviridae family
    Oyvind Haugland
    Department of Basic Sciences and Aquatic Medicine, Norwegian School of Veterinary Science, Oslo, Norway
    J Virol 85:5275-86. 2011
    ..The identification of the causative agent for CMS is important for improved disease surveillance and disease control and will serve as a basis for vaccine development against the disease...
  19. ncbi Temperature-dependent expression of immune-relevant genes in rainbow trout following Yersinia ruckeri vaccination
    Martin K Raida
    Department of Veterinary Pathobiology, Section of Fish Diseases, Faculty of Life Sciences, The University of Copenhagen, Stigbøjlen 7, 1870 Frederiksberg C, Denmark
    Dis Aquat Organ 77:41-52. 2007
    ..The study indicated that expression of both innate and specific adaptive immune-response genes are highly temperature-dependent in rainbow trout...
  20. pmc Genetic dissection of MHC-associated susceptibility to Lepeophtheirus salmonis in Atlantic salmon
    Karim Gharbi
    Institute of Comparative Medicine, University of Glasgow, Glasgow, UK
    BMC Genet 10:20. 2009
    ..In this study, we used quantitative trait locus (QTL) analysis to test the effect of genomic regions linked to MHC class I and II on linkage groups (LG) 15 and 6, respectively...
  21. pmc A novel totivirus and piscine reovirus (PRV) in Atlantic salmon (Salmo salar) with cardiomyopathy syndrome (CMS)
    Marie Løvoll
    Section for Virology and Serology, National Veterinary Institute, P, O, Box 750 Sentrum, 0106 Oslo, Norway
    Virol J 7:309. 2010
    ..In the present work we have studied whether PRV or other infectious agents may be involved in the etiology of CMS...
  22. ncbi The susceptibility of Atlantic salmon fry to freshwater infectious pancreatic necrosis is largely explained by a major QTL
    R D Houston
    The Roslin Institute and Royal Dick School of Veterinary Studies, University of Edinburgh, Roslin Biocentre, Midlothian, UK
    Heredity (Edinb) 105:318-27. 2010
    ..These results have clear scientific and practical implications for the control of IPN...
  23. ncbi Identification and expression profiling analysis of grass carp Ctenopharyngodon idella LGP2 cDNA
    Teng Huang
    College of Animal Science and Technology, Northwest A and F University, Shaanxi Key Laboratory of Molecular Biology for Agriculture, Yangling 712100, China
    Fish Shellfish Immunol 29:349-55. 2010
    ....
  24. ncbi Synopsis of the species of Myxobolus Butschli, 1882 (Myxozoa: Myxosporea: Myxobolidae)
    J C Eiras
    Departamento de Zoologia e Antropologia, Faculdade de Ciências and CIIMAR, Universidade do Porto, 4099 002, Porto, Portugal
    Syst Parasitol 61:1-46. 2005
    ..For each species, the relevant morphometric and morphological data are indicated, as well as the host(s), site(s) of infection within the host and type-locality...
  25. ncbi Phylogenetic analysis of infectious salmon anaemia virus isolates from Norway, Canada and Scotland
    B Krossøy
    Department of Fisheries and Marine Biology, University of Bergen, Norway
    Dis Aquat Organ 44:1-6. 2001
    ....
  26. ncbi Heart and skeletal muscle inflammation in Atlantic salmon, Salmo salar L: a new infectious disease
    R T Kongtorp
    National Veterinary Institute, Oslo, Norway
    J Fish Dis 27:351-8. 2004
    ..Further investigations are required in order to make conclusions regarding the cause and pathogenesis of HSMI...
  27. ncbi A comparative review on European-farmed finfish RNA viruses and their vaccines
    E Gomez-Casado
    Instituto Nacional Investigaciones Agrarias, Dpto Biotecnología, INIA, 28040 Madrid, Spain
    Vaccine 29:2657-71. 2011
    ....
  28. ncbi Saprophytism of a fish pathogen as a transmission strategy
    Heidi M T Kunttu
    University of Jyvaskyla, Department of Biological and Environmental Science, University of Jyvaskyla, Finland
    Epidemics 1:96-100. 2009
    ..columnare. Our findings also suggest that F. columnare may be able to persist in the rearing environment during antibiotic treatments of the living fish...
  29. ncbi Differential rejection of salmon lice by pink and chum salmon: disease consequences and expression of proinflammatory genes
    Simon R M Jones
    Pacific Biological Station, 3190 Hammond Bay Road, Fisheries and Oceans Canada, Nanaimo, British Columbia V9T 6N7, Canada
    Dis Aquat Organ 75:229-38. 2007
    ..Together, these observations indicate a relatively enhanced innate resistance to L. salmonis in the juvenile pink salmon compared with the juvenile chum salmon...
  30. ncbi Establishment and characterisation of salmon louse (Lepeophtheirus salmonis (Krøyer 1837)) laboratory strains
    Lars A Hamre
    Institute of Marine Research, Nordnes, Norway
    Parasitol Int 58:451-60. 2009
    ..It is suggested that the culturing system, and the strains produced represent a significant resource for future research on this parasite...
  31. ncbi Teleost fish interferons and their role in immunity
    Jun Zou
    Scottish Fish Immunology Research Centre, School of Biological Sciences, University of Aberdeen, Aberdeen AB24 2TZ, UK
    Dev Comp Immunol 35:1376-87. 2011
    ....
  32. pmc Confirmation and fine-mapping of a major QTL for resistance to infectious pancreatic necrosis in Atlantic salmon (Salmo salar): population-level associations between markers and trait
    Thomas Moen
    Aqua Gen AS, Trondheim, Norway
    BMC Genomics 10:368. 2009
    ..The aim of this study was to identify and fine-map QTL for IPN-resistance in Atlantic salmon, for use in marker-assisted selection to increase the rate of genetic improvement for this trait...
  33. pmc Fishborne zoonotic intestinal trematodes, Vietnam
    Do Trung Dung
    National Institute of Malariology, Parasitology and Entomology, Hanoi, Vietnam
    Emerg Infect Dis 13:1828-33. 2007
    ..90.4% of all worms recovered). These results demonstrate that fishborne intestinal parasites are an unrecognized food safety risk in a country whose people have a strong tradition of eating raw fish...
  34. pmc The efficacy of emamectin benzoate against infestations of Lepeophtheirus salmonis on farmed Atlantic salmon (Salmo salar L) in Scotland, 2002-2006
    Fiona Lees
    Department of Statistics and Modelling Science, University of Strathclyde, Glasgow, United Kingdom
    PLoS ONE 3:e1549. 2008
    ..This study investigates trends in the efficacy of the in-feed treatment emamectin benzoate in Scotland, the active ingredient most widely used across all salmon producing regions...
  35. pmc A major effect quantitative trait locus for whirling disease resistance identified in rainbow trout (Oncorhynchus mykiss)
    M R Baerwald
    Genomic Variation Laboratory, Department of Animal Science, University of California, Davis, CA 95616, USA
    Heredity (Edinb) 106:920-6. 2011
    ..This is the first genetic region discovered that contributes directly to the whirling disease phenotype and the finding moves the field closer to a mechanistic understanding of resistance to this important disease of salmonid fish...
  36. ncbi Activation of cytokine expression occurs through the TNFα/NF-κB-mediated pathway in birnavirus-infected cells
    Wei Lun Wang
    Institute of Cellular and Organismic Biology, Academia Sinica, Nankang 115, Taipei, Taiwan
    Fish Shellfish Immunol 31:10-21. 2011
    ..The modulation of TNFα/NF-κB-related mechanisms may provide a therapeutic strategy for inhibiting viral infection in teleosts...
  37. ncbi Comparative study of the immune effect of an Edwardsiella tarda antigen in two forms: subunit vaccine vs DNA vaccine
    Yun Sun
    Institute of Oceanology, Chinese Academy of Sciences, 7 Nanhai Road, Qingdao 266071, PR China Graduate University of the Chinese Academy of Sciences, Beijing 100049, PR China
    Vaccine 29:2051-7. 2011
    ..Taken together, these results indicate that both rEta2 and pCEta2 induce specific and nonspecific immunities, however, pCEta2 induces both B cell and T cell responses, whereas rEta2 induces mainly humoral response...
  38. ncbi A piscirickettsiosis-like syndrome in cultured Nile tilapia in Latin America with Francisella spp. as the pathogenic agent
    M J Mauel
    Thad Cochran National Warmwater Aquaculture Center, College of Veterinary Medicine, Mississippi State University, Post Office Box 197, Stoneville, Mississippi 38776, USA
    J Aquat Anim Health 19:27-34. 2007
    ..sequences previously identified in tilapias Oreochromis spp. (Taiwan), Atlantic cod Gadus morhua (Norway), and three-line grunts Parapristipoma trilineatum (Japan)...
  39. ncbi Is the population genetic structure of complex life cycle parasites determined by the geographic range of the most motile host?
    Katja Riikka Louhi
    Department of Biological and Environmental Science, Centre of Excellence in Evolutionary Research, University of Jyvaskyla, Finland
    Infect Genet Evol 10:1271-7. 2010
    ..Our results suggest that parasite dispersal in the definitive host may limit local cycling of the parasites in the intermediate host populations...
  40. ncbi Increasing water temperature and disease risks in aquatic systems: climate change increases the risk of some, but not all, diseases
    Anssi Karvonen
    Department of Biological and Environmental Science, Centre of Excellence in Evolutionary Research, University of Jyvaskyla, Jyvaskyla, Finland
    Int J Parasitol 40:1483-8. 2010
    ....
  41. pmc Fish-borne zoonotic trematodes in cultured and wild-caught freshwater fish from the Red River Delta, Vietnam
    Van Thi Phan
    Centre for Environment and Disease Monitoring in Aquaculture, Research Institute for Aquaculture No 1, Tu Son, Vietnam
    Vector Borne Zoonotic Dis 10:861-6. 2010
    ..These results underscore the need for greater awareness of the risk from raw fish dishes among public health agencies and consumers...
  42. ncbi Zebrafish as a model for infectious disease and immune function
    Con Sullivan
    Department of Biochemistry, University of Maine, Orono, ME 04469, USA
    Fish Shellfish Immunol 25:341-50. 2008
    ..In this review, the capabilities and potential of the zebrafish model system will be discussed and an overview of information on zebrafish infectious disease models will be presented...
  43. ncbi Yersinia ruckeri biotype 2 isolates from mainland Europe and the UK likely represent different clonal groups
    Richard W Wheeler
    CEFAS Weymouth Laboratory, The Nothe, Barrack Road, Weymouth, Dorset DT4 8UB, UK
    Dis Aquat Organ 84:25-33. 2009
    ..UK Atlantic salmon isolates were genetically and serologically diverse, with 12 distinct pulsotypes identified among 32 isolates...
  44. pmc Intensive fish farming and the evolution of pathogen virulence: the case of columnaris disease in Finland
    K Pulkkinen
    Department of Biological and Environmental Science, University of Jyvaskyla, PO Box 35, FI 40014 Jyvaskyla, Finland
    Proc Biol Sci 277:593-600. 2010
    ..columnare. This effect is intensified by the recent increases in summer water temperature. More generally, we predict that intensive fish farming will lead to the evolution of more virulent pathogens...
  45. pmc Whole-body analysis of a viral infection: vascular endothelium is a primary target of infectious hematopoietic necrosis virus in zebrafish larvae
    Marion Ludwig
    Macrophages et Développement de l Immunité, Institut Pasteur, Paris, France
    PLoS Pathog 7:e1001269. 2011
    ..This tractable system will allow the in vivo dissection of host-virus interactions at the whole organism scale, a feature unrivalled by other vertebrate models...
  46. pmc Transcription of reference genes used for quantitative RT-PCR in Atlantic salmon is affected by viral infection
    Marie Løvoll
    Section for immunoprophylaxis, National Veterinary Institute, P, O, Box 750 Sentrum, 0106 Oslo, Norway
    Vet Res 42:8. 2011
    ..The results emphasize the need for thorough method validation prior to transcriptional studies during viral infections...
  47. ncbi Individual fish tank arrays in studies of Lepeophtheirus salmonis and lice loss variability
    Lars Are Hamre
    Department of Biology, University of Bergen, PO Box 7800, Bergen 5020, Norway
    Dis Aquat Organ 97:47-56. 2011
    ..The loss of females appeared to be a process somewhat selective against large individuals. Inherent qualities of the host appeared to be of little significance in explaining the variability in loss of preadult/adult lice...
  48. ncbi Life history and virulence are linked in the ectoparasitic salmon louse Lepeophtheirus salmonis
    A Mennerat
    Department of Biology, University of Bergen, Bergen, Norway
    J Evol Biol 25:856-61. 2012
    ..Our study highlights that salmon lice, therefore, are a good model for studying how human activity may affect the evolution of parasite virulence...
  49. ncbi First detection of piscine reovirus (PRV) in marine fish species
    Christer R Wiik-Nielsen
    Norwegian Veterinary Institute, PO Box 750 Sentrum, 0106 Oslo, Norway
    Dis Aquat Organ 97:255-8. 2012
    ..The virus was found in few of the analyzed samples so there is probably a more complex relationship that involves several carriers and virus -reservoirs...
  50. pmc Evidence of an antimicrobial-immunomodulatory role of Atlantic salmon cathelicidins during infection with Yersinia ruckeri
    Andrew Bridle
    National Centre for Marine Conservation and Resource Sustainability, University of Tasmania, Tasmania, Australia
    PLoS ONE 6:e23417. 2011
    ..ruckeri . We propose that Atlantic salmon cathelicidins participate in the interplay between the innate and adaptive immune systems via the release of cytokines enabling a more effective response to invading pathogens...
  51. ncbi Vibrio anguillarum as a fish pathogen: virulence factors, diagnosis and prevention
    I Frans
    Laboratory for Process Microbial Ecology and Bioinspirational Management, Consortium for Industrial Microbiology and Biotechnology, Department of Microbial and Molecular Systems, K U Leuven Association, Lessius Mechelen, Sint Katelijne Waver, Belgium
    J Fish Dis 34:643-61. 2011
    ..This review summarizes the current state of knowledge pertaining to V. anguillarum, focusing on pathogenesis, known virulence factors, diagnosis, prevention and treatment...
  52. pmc Immunohistochemical detection of piscine reovirus (PRV) in hearts of Atlantic salmon coincide with the course of heart and skeletal muscle inflammation (HSMI)
    Oystein Wessel Finstad
    Department of Food Safety and Infection Biology, Norwegian School of Veterinary Science, Postboks 8146 Dep, N 0033 OSLO Norwegian, Norway
    Vet Res 43:27. 2012
    ..Immunohistochemical detection of PRV antigens will be beneficial for the understanding of the pathogenesis of HSMI as well as for diagnostic purposes...
  53. ncbi Immune gene expression in trout cell lines infected with the fish pathogenic oomycete Saprolegnia parasitica
    Irene de Bruijn
    Aberdeen Oomycete Laboratory, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, UK
    Dev Comp Immunol 38:44-54. 2012
    ..parasitica. These results demonstrate that particular immune genes are up-regulated in response to S. parasitica infection and that AMPs may play a crucial role in the first line of defence against oomycetes in fish...
  54. ncbi Molecular profiling of the gilthead sea bream (Sparus aurata L.) response to chronic exposure to the myxosporean parasite Enteromyxum leei
    Grace C Davey
    Ryan Institute, National University of Ireland Galway, Ireland
    Mol Immunol 48:2102-12. 2011
    ....
  55. pmc Genome sequence of the fish pathogen Flavobacterium columnare ATCC 49512
    Hasan C Tekedar
    College of Veterinary Medicine, Mississippi State University, Mississippi, USA
    J Bacteriol 194:2763-4. 2012
    ..Flavobacterium columnare is a Gram-negative, rod-shaped, motile, and highly prevalent fish pathogen causing columnaris disease in freshwater fish worldwide. Here, we present the complete genome sequence of F. columnare strain ATCC 49512...
  56. ncbi Analysis and management of resistance to chemotherapeutants in salmon lice, Lepeophtheirus salmonis (Copepoda: Caligidae)
    Ian Denholm
    Plant and Invertebrate Ecology Division, IACR Rothamsted, Harpenden AL5 2JQ, UK
    Pest Manag Sci 58:528-36. 2002
    ..An EU-funded project named SEARCH (QLK2-CT-2000-00809) has been initiated to explore in more detail the diagnosis, incidence, dynamics and management of resistance to chemotherapeutants in L salmonis...
  57. ncbi Low virulent infectious salmon anaemia virus (ISAV-HPR0) is prevalent and geographically structured in Norwegian salmon farming
    Trude M Lyngstad
    Norwegian Veterinary Institute, PO Box 750 Sentrum, 0106 Oslo, Norway
    Dis Aquat Organ 101:197-206. 2012
    ..Finally, we found a spatial association between fish groups with virulent ISAV (n = 21) and fish groups with ISAV-HPR0 (n = 27), supporting the hypothesis that ISAV-HPR0 may undergo a transition to virulent ISAV...
  58. pmc Prevention and control of fish-borne zoonotic trematodes in fish nurseries, Vietnam
    Jesper Hedegaard Clausen
    Department of Veterinary Disease Biology, Faculty of Health and Medical Sciences, University of Copenhagen, Grønnegaardsvej 15, DK 1870 Frederiksberg C, Denmark
    Emerg Infect Dis 18:1438-45. 2012
    ..These interventions can be used in the development of programs for sustained control of zoonotic trematodes in farmed fish...
  59. ncbi Gene expression profiles of the spleen, liver, and head kidney in turbot (Scophthalmus maximus) along the infection process with Aeromonas salmonicida using an immune-enriched oligo-microarray
    Adrián Millán
    Departamento de Genetica, Facultad de Veterinaria, Campus de Lugo, Universidad de Santiago de Compostela, 27002 Lugo, Spain
    Mar Biotechnol (NY) 13:1099-114. 2011
    ..The information obtained will aid to understand the turbot immune response and will specifically be valuable to develop strategies of defense to A. salmonicida to achieve more resistant broodstocks for turbot industry...
  60. ncbi Microarray-based identification of differentially expressed genes in families of turbot (Scophthalmus maximus) after infection with viral haemorrhagic septicaemia virus (VHSV)
    P Diaz-Rosales
    Instituto de Investigaciones Marinas, Consejo Superior de Investigaciones Cientificas, Eduardo Cabello 6, Vigo, Spain
    Mar Biotechnol (NY) 14:515-29. 2012
    ..The present study serves as an initial screen for genes of interest and provides an extensive overview of the genetic basis underlying the differences between families that are resistant or susceptible to VHSV infection...
  61. ncbi Interferon type I responses to virus infections in carp cells: In vitro studies on Cyprinid herpesvirus 3 and Rhabdovirus carpio infections
    Mikołaj Adamek
    Fish Disease Research Unit, Centre of Infectious Diseases, University of Veterinary Medicine Hannover, Bunteweg 17, D 30559 Hannover, Germany
    Fish Shellfish Immunol 33:482-93. 2012
    ..This would open the opportunity to treat the disease associated with CyHV-3 by an application of poly I:C in certain cases...
  62. ncbi Molecular evolutionary and epidemiological dynamics of a highly pathogenic fish rhabdovirus, the spring viremia of carp virus (SVCV)
    Abinash Padhi
    Center for Infectious Disease Dynamics, Department of Biology, 208 Mueller Laboratory, The Pennsylvania State University, University Park, PA 16802, USA
    Vet Microbiol 156:54-63. 2012
    ....
  63. ncbi Evolution of infectious salmon anaemia virus (ISA virus)
    Heidrun Plarre
    Department of Biology, University of Bergen, Thormøhlensgt 55, 5020 Bergen, Norway
    Arch Virol 157:2309-26. 2012
    ..The TMRCA data also suggest that the ISA viruses in Chile were transmitted from Norway in the period from 1995 to 2007, depending on which of the four genes were used in the analysis...
  64. ncbi Teleost TLR22 recognizes RNA duplex to induce IFN and protect cells from birnaviruses
    Aya Matsuo
    Department of Microbiology and Immunology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    J Immunol 181:3474-85. 2008
    ..TLR22 may be a functional substitute of human cell-surface TLR3 and serve as a surveillant for infection with dsRNA virus to alert the immune system for antiviral protection in fish...
  65. pmc Genetic resistance to rhabdovirus infection in teleost fish is paralleled to the derived cell resistance status
    Eloi R Verrier
    INRA, Molecular Virology and Immunology, Jouy en Josas, France
    PLoS ONE 7:e33935. 2012
    ..This collection of clonal fish and isogenic cell lines provides an interesting model to analyze the relative contribution of antiviral pathways to the resistance to different viruses...
  66. ncbi Differential immune response of rainbow trout (Oncorhynchus mykiss) at early developmental stages (larvae and fry) against the bacterial pathogen Yersinia ruckeri
    Jiwan K Chettri
    University of Copenhagen, Faculty of Life Sciences, Department of Veterinary Disease Biology, Frederiksberg C, Denmark
    Dev Comp Immunol 36:463-74. 2012
    ..A dense covering of surfaces of gill filaments by IgT antibody in the young fish suggest a role of this antibody as innate immune factor at early developmental stages...
  67. pmc Impact of early salmon louse, Lepeophtheirus salmonis, infestation and differences in survival and marine growth of sea-ranched Atlantic salmon, Salmo salar L., smolts 1997-2009
    O T Skilbrei
    Institute of Marine Research, Nordnes, Bergen, Norway
    J Fish Dis 36:249-60. 2013
    ..05) and equivalent to an odds ratio of the probability of being recaptured of 1.17 in favour of the treated smolts. Control fish also tended to be smaller as grilse (P = 0.057), possibly due to a sublethal effect of salmon lice...
  68. ncbi Gene expression profiling in naïve and vaccinated rainbow trout after Yersinia ruckeri infection: insights into the mechanisms of protection seen in vaccinated fish
    Nor Omaima Harun
    Scottish Fish Immunology Research Centre, University of Aberdeen, Institute of Biological and Environmental Sciences, Tillydrone Avenue, Aberdeen AB24 2TZ, Scotland, UK
    Vaccine 29:4388-99. 2011
    ..Thus, it is possible that different types of adaptive responses are on-going within the vaccinated fish during infection with Y. ruckeri, potentially affected by the site and stage of infection...
  69. ncbi Vibriosis vaccines based on various sero-subgroups of Vibrio anguillarum O2 induce specific protection in Atlantic cod (Gadus morhua L.) juveniles
    Helene Mikkelsen
    NOFIMA Marin, PO Box 6122, N 9291 Tromsø, Norway
    Fish Shellfish Immunol 30:330-9. 2011
    ..However, in groups vaccinated against V. anguillarum sero-subgroups O2b or O2, IL-12p40 and IFNγ gene expression were slightly increased 3 and 55 days post vaccination, respectively...
  70. ncbi Immunological responses of turbot (Psetta maxima) to nodavirus infection or polyriboinosinic polyribocytidylic acid (pIC) stimulation, using expressed sequence tags (ESTs) analysis and cDNA microarrays
    Kyoung C Park
    Institute for Marine Biosciences, National Research Council of Canada, Halifax, NS, Canada
    Fish Shellfish Immunol 26:91-108. 2009
    ..Our results indicate that certain genes in turbot have important roles in immune responses to nodavirus infection and dsRNA stimulation...
  71. ncbi Fish immunity and parasite infections: from innate immunity to immunoprophylactic prospects
    Pilar Alvarez-Pellitero
    Instituto de Acuicultura de Torre de la Sal, Consejo Superior de Investigaciones Cientificas, Torre de la Sal s n, 12595 Ribera de Cabanes, Castellon, Spain
    Vet Immunol Immunopathol 126:171-98. 2008
    ..The known information points to the need for integrated studies of the mechanisms involved in protection, in order to choose the optimum antigen candidates, adjuvants and formulations...
  72. ncbi Surveillance of health status on eight marine rainbow trout, Oncorhynchus mykiss (Walbaum), farms in Denmark in 2006
    K Pedersen
    National Veterinary Institute, Technical University of Denmark, Arhus N, Denmark
    J Fish Dis 31:659-67. 2008
    ..Both mortality and number of antimicrobial treatments during the period were considerably higher in unvaccinated compared with vaccinated fish. Resistance to commonly used antimicrobials was low or absent...
  73. ncbi Epitheliocystis in fish
    B F Nowak
    School of Aquaculture, University of Tasmania, Launceston, Tasmania, Australia
    J Fish Dis 29:573-88. 2006
    ..High stocking densities, presence of nutrients, season, temperature and fish age have been identified as potential risk factors for the manifestation of this condition...
  74. pmc Major quantitative trait loci affect resistance to infectious pancreatic necrosis in Atlantic salmon (Salmo salar)
    Ross D Houston
    Division of Genetics and Genomics, Roslin Institute and Royal Dick School of Veterinary Studies, Roslin Biocentre, Midlothian, United Kingdom
    Genetics 178:1109-15. 2008
    ..The identified QTL can be applied in marker-assisted selection programs to improve the resistance of salmon to IPN and reduce disease-related mortality...
  75. ncbi Modelling sea lice dispersion under varying environmental forcing in a Scottish sea loch
    T L Amundrud
    FRS Marine Laboratory, Aberdeen, UK
    J Fish Dis 32:27-44. 2009
    ....
  76. pmc Gene expression analyses of immune responses in Atlantic salmon during early stages of infection by salmon louse (Lepeophtheirus salmonis) revealed bi-phasic responses coinciding with the copepod-chalimus transition
    Tariku Markos Tadiso
    Department of Biology, University of Bergen, Norway
    BMC Genomics 12:141. 2011
    ....
  77. ncbi Immunohistochemistry and pathology of multiple Great Lakes fish from mortality events associated with viral hemorrhagic septicemia virus type IVb
    L Al-Hussinee
    Fish Pathology Laboratory, Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, Ontario, N1G 2W1, Canada
    Dis Aquat Organ 93:117-27. 2011
    ..By contrast, renal tubules and gonadal tissues (ovary and testis), were strongly immunopositive for VHSV IVb, but no lesions were noted...
  78. ncbi Differential expression and biological activity of two piscidin paralogues and a novel splice variant in Atlantic cod (Gadus morhua L.)
    Jareeporn Ruangsri
    Faculty of Biosciences and Aquaculture, University of Nordland, Mørkved, 8049 Bodø, Norway
    Fish Shellfish Immunol 32:396-406. 2012
    ..Moreover, the two pis paralogues have undergone structural diversification and it is likely that they play multifunctional roles in Atlantic cod...
  79. ncbi Transcriptome analysis of rainbow trout infected with high and low virulence strains of infectious hematopoietic necrosis virus
    Maureen K Purcell
    Western Fisheries Research Center, US Geological Survey, 6505 NE 65th Street, Seattle, WA 98115, USA
    Fish Shellfish Immunol 30:84-93. 2011
    ..Slower replication of the U virus may allow the host more time to induce protective anti-viral immune mechanisms...
  80. ncbi Novel Chlamydiales associated with epitheliocystis in a leopard shark Triakis semifasciata
    A Polkinghorne
    Institute of Veterinary Pathology, University of Zurich, Winterthurerstrasse 268, Zurich 8057, Switzerland
    Dis Aquat Organ 91:75-81. 2010
    ..A greater understanding of the genetic diversity of marine Chlamydiales will assist our attempts to manage and control epitheliocystis outbreaks and to understand the evolution of this unique obligate intracellular pathogen...
  81. ncbi Identification and characterization of Japanese flounder, Paralichthys olivaceus interferon-stimulated gene 15 (Jf-ISG15)
    Motoshige Yasuike
    Laboratory of Genome Science, Graduate School of Marine Science and Technology, Tokyo University of Marine Science and Technology, Konan, Minato, Japan
    Comp Immunol Microbiol Infect Dis 34:83-91. 2011
    ....
  82. pmc Molecular evidence for association of chlamydiales bacteria with epitheliocystis in leafy seadragon (Phycodurus eques), silver perch (Bidyanus bidyanus), and barramundi (Lates calcarifer)
    Adam Meijer
    Diagnostic Laboratory for Infectious Diseases and Screening, National Institute of Public Health and the Environment RIVM, PO Box 1, 3720 BA Bilthoven, The Netherlands
    Appl Environ Microbiol 72:284-90. 2006
    ..In addition, the results suggested that lymphocystis cysts, known to be caused by iridovirus infection, could be coinfected with the epitheliocystis agent...
  83. pmc Transcriptome profiling of immune responses to cardiomyopathy syndrome (CMS) in Atlantic salmon
    Gerrit Timmerhaus
    Nofima AS, As, Norway
    BMC Genomics 12:459. 2011
    ..Here we present the first characterisation of host immune responses to CMS assessed by microarray transcriptome profiling...
  84. ncbi Genomic survey of early responses to viruses in Atlantic salmon, Salmo salar L
    Aleksei Krasnov
    Nofima, 1432 As, Norway
    Mol Immunol 49:163-74. 2011
    ..Apparently, a number of genes involved in antiviral responses in salmon have acquired different functional roles in higher vertebrates...
  85. ncbi Epitheliocystis in Atlantic salmon, Salmo salar L., farmed in fresh water in Ireland is associated with 'Candidatus Clavochlamydia salmonicola' infection
    S O Mitchell
    Vet Aqua International, Oranmore, Ireland
    J Fish Dis 33:665-73. 2010
    ..Both RT-PCR and histopathological examination indicate that the organism disappears from the gills 4-6 weeks post-transfer...
  86. pmc IPNV with high and low virulence: host immune responses and viral mutations during infection
    Astrid Skjesol
    Norwegian College of Fishery Sciences, University of Tromsø, N 9037 Tromsø, Norway
    Virol J 8:396. 2011
    ..However little is known about the rates and modes of sequence divergence and molecular mechanisms that determine virulence. Also how the host response may influence IPNV virulence is poorly described...
  87. pmc Farm-level risk factors for fish-borne zoonotic trematode infection in integrated small-scale fish farms in northern Vietnam
    Van Thi Phan
    Department of Large Animal Sciences, Section of Veterinary Epidemiology, Faculty of Life Sciences, University of Copenhagen, Frederiksberg, Denmark
    PLoS Negl Trop Dis 4:e742. 2010
    ..Interventions in aquaculture should be based on knowledge of the main risk factors associated with FZT transmission...
  88. ncbi Cellular and molecular immune responses of the sea bass (Dicentrarchus labrax) experimentally infected with betanodavirus
    G Scapigliati
    Dipartimento di Scienze Ambientali, Largo dell Universita, Universita degli Studi della Tuscia, Viterbo 01100, Italy
    Fish Shellfish Immunol 28:303-11. 2010
    ..Overall, our work represents a first comprehensive analysis of cellular and molecular immune parameters in a fish species exposed to a pathogenic virus...
  89. ncbi Pathology of heart and skeletal muscle inflammation (HSMI) in farmed Atlantic salmon Salmo salar
    R T Kongtorp
    National Veterinary Institute, Oslo, Norway
    Dis Aquat Organ 59:217-24. 2004
    ..Microscopic lesions are compared and discussed in relation to published descriptions of pancreas disease (PD) and cardiomyopathy syndrome (CMS). It is concluded that HSMI is histopathologically distinguishable from PD and CMS...
  90. ncbi A framework for understanding the potential for emerging diseases in aquaculture
    Alexander G Murray
    Fisheries Research Services, P O Box 101, 357 Victoria Rd, Aberdeen, AB11 9DB, UK
    Prev Vet Med 67:223-35. 2005
    ..The rate and extent of emergence can be reduced by the application of biosecurity programmes designed to mitigate the risk factors for disease emergence...
  91. ncbi Francisella sp. (Family Francisellaceae) causing mortality in Norwegian cod (Gadus morhua) farming
    Are Nylund
    Department of Biology, University of Bergen, Thormohlensgt 55, 5020 Bergen, Norway
    Arch Microbiol 185:383-92. 2006
    ..philomiragia of 77.3 and 98.2%, respectively. Based on sequence data, culturing temperatures and pathogenicity for cod, it is suggested that this Francisella sp. from cod could be a new species of Francisella, Family Francisellaceae...
  92. ncbi Infectious pancreatic necrosis virus induces apoptosis in vitro and in vivo independent of VP5 expression
    Nina Santi
    Section for Pathology, National Veterinary Institute, 0033 Oslo, Norway
    Virology 342:13-25. 2005
    ....
  93. ncbi Infectious pancreatic necrosis virus: biology, pathogenesis, and diagnostic methods
    Sylvia Rodriguez Saint-Jean
    Laboratorio de Virus, Departamento de Microbiología Molecular Centro de Investigaciones Biológicas Consejo Superior de Investigaciones Científicas C Velazquez 144, 28006 Madrid, Spain
    Adv Virus Res 62:113-65. 2003
  94. ncbi Identification of putative motifs involved in the virulence of infectious pancreatic necrosis virus
    Nina Santi
    Department of Pathology, National Veterinary Institute, Oslo, Norway
    Virology 322:31-40. 2004
    ....
  95. ncbi Hosts and parasites as aliens
    H Taraschewski
    Zoologisches Institut I, Okologie Parasitologie, Universitat Karlsruhe, Kornblumenstrasse 13, 76128 Karlsruhe, Germany
    J Helminthol 80:99-128. 2006
    ..Summarizing all we know about hosts and parasites as aliens, tentative patterns and principles can be figured out, but individual case studies teach us that generalizations should be avoided...
  96. ncbi In vitro viral haemorrhagic septicaemia virus replication in excised fins of rainbow trout: correlation with resistance to waterborne challenge and genetic variation
    E Quillet
    , Institut National de la Recherche Agronomique, Jouy-en-Josas, France
    Dis Aquat Organ 45:171-82. 2001
    ....
  97. ncbi A star with stripes: zebrafish as an infection model
    Astrid M van der Sar
    Department of Medical Microbiology, Vrije Universiteit Medical Centre, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    Trends Microbiol 12:451-7. 2004
  98. ncbi Major histocompatibility complex (MHC) variation and susceptibility to the sea louse Lepeophtheirus salmonis in Atlantic salmon Salmo salar
    K A Glover
    Institute of Marine Research, PO Box 1870, Nordnes, 5817 Bergen, Norway
    Dis Aquat Organ 76:57-65. 2007
    ..Consequently, the results of this study indicate a link between MHC Class II and susceptibility to lice...
  99. ncbi Prevalence of fishborne zoonotic parasites in important cultured fish species in the Mekong Delta, Vietnam
    Pham Cu Thien
    Department of Veterinary Pathobiology, Faculty of Life Sciences, University of Copenhagen, 1870, Frederiksberg C, Denmark
    Parasitol Res 101:1277-84. 2007
    ..The results indicate that certain fish production systems are at risk for FZT, and control approaches will benefit from understanding these risk factors...
  100. pmc Characterization of "Candidatus piscichlamydia salmonis" (order Chlamydiales), a chlamydia-like bacterium associated with epitheliocystis in farmed Atlantic salmon (Salmo salar)
    Andrew Draghi
    Department of Pathobiology and Veterinary Science, University of Connecticut, Storrs, CT 06269 3089, USA
    J Clin Microbiol 42:5286-97. 2004
    ....
  101. pmc vig-1, a new fish gene induced by the rhabdovirus glycoprotein, has a virus-induced homologue in humans and shares conserved motifs with the MoaA family
    P Boudinot
    Institut National de la Recherche Agronomique, Unite de Virologie et Immunologie Moleculaires, 78352 Jouy en Josas Cedex, France
    J Virol 73:1846-52. 1999
    ..This suggests that the function of vig-1 may be involved in the nonspecific virus-induced synthesis of enzymatic cofactors of the nitric oxide pathway...

Research Grants22

  1. Specific Contribution of a New IG Isotype (IGT) in Teleost Fish Immune Responses
    J Oriol Sunyer; Fiscal Year: 2013
    ..Therefore, a better knowledge of the fish immune system is essential to the development of new therapeutic agents and vaccines to prevent fish diseases.
  2. MUTANT LINES OF ZEBRAFISH HIGHLY SENSITIVE TO NEOPLASIA
    Jan Spitsbergen; Fiscal Year: 2005
    ..These lines of zebrafish will provide an efficient and inexpensive system for development of new treatment and prevention strategies for cancer, and will help identify new genes controlling growth and differentiation. ..
  3. SYNTHESIS OF ANTITUMOR NATURAL PRODUCTS
    Yoshito Kishi; Fiscal Year: 2008
    ..These studies will provide clues for developing better antitumor drugs and/or will help to deliver a new anticancer drug to patients at an acceptable cost. [unreadable] [unreadable]..
  4. Intracellular mechanisms of reovirus genome replication and particle assembly
    MAX NIBERT; Fiscal Year: 2007
    ..abstract_text> ..
  5. Characteristics of a putative steroid membrane receptor
    Peter Thomas; Fiscal Year: 2010
    ..However, it is important to establish these points for the mPR. In addition, the studies should provide indications of important regulatory events that might occur in human cells. ..
  6. Molecular Mechanisms in Reovirus mRNA Synthesis
    MAX NIBERT; Fiscal Year: 2006
    ..The results of these studies will enhance our understanding of the reovirus core as an elegantly designed molecular machine for mRNA synthesis. ..
  7. REOVIRUS OUTER-CAPSID ASSEMBLY & FUNCTIONS IN CELL ENTRY
    MAX NIBERT; Fiscal Year: 2005
    ..These in vitro recoating methods have been adapted into a new style of molecular genetic analysis of reovirus outer-capsid structure and function by using mutant forms of recombinant proteins for recoating. ..
  8. Regulated expression of B. burgdorferi virulence genes
    FELIPE CARDENAS CABELLO; Fiscal Year: 2010
    ..burgdorferi. These tools will be used to identify genes that are potentially responsible for this organism's virulence and which could be targets for new vaccines and antibiotics against Lyme disease. ..
  9. SYNTHETIC STUDIES ON COMPLEX NATURAL PRODUCTS
    Yoshito Kishi; Fiscal Year: 2003
    ..These studies are again expected to stimulate progress in medicine. ..
  10. MECHANISMS OF REPRODUCTIVE NEUROENDOCRINE TOXICITY
    Peter Thomas; Fiscal Year: 2005
    ..The proposed study will investigate a novel mechanism of PCB neurotoxicity and neuroendocrine toxicity which may also have significance for other neural functions such as those associated with mental health. ..
  11. MAPPING ZEBRAFISH CHROMOSOMES USING MULTICOLOR FISH
    Ruth Phillips; Fiscal Year: 2002
    ..This would be very helpful in positional candidate cloning of zebrafish mutants. ..
  12. Uptake and Processing of Foreign DNA by Mitochondria, a Model System
    MICHAEL SCHMALE; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  13. PREVENTION OF NEURAL TUBE DEFECTS BY IMMUNE STIMULATION
    THERESA HRUBEC; Fiscal Year: 2007
    ..Steven Holladay and Ansar Ahmed of the Virginia-Maryland Regional College of Veterinary Medicine at the VPISU, and will offer excellent training and career development for Dr. Hrubec. ..
  14. Animal Model of Transmissable Neurofibromas
    MICHAEL SCHMALE; Fiscal Year: 2006
    ..The proposed studies should yield information on mechanisms of tumor development in the peripheral nervous system applicable to understanding these processes in human disorders such as neurofibromatosis type 1. ..
  15. Stringent response and bmp expression in B. burgdorferi
    Felipe Cabello; Fiscal Year: 2007
    ..burgdorferi from a descriptive paradigm to a paradigm framed by mechanistic and causal interpretations. ..
  16. AGING, GENE EXPRESSION AND OXIDATIVE STRESS
    Evan Keller; Fiscal Year: 2002
    ....
  17. Prostate Cancer Metastasis Suppressor: Role of RKIP
    Evan Keller; Fiscal Year: 2008
    ..when completed, we hope this work will lead to a better understanding of the mechanisms through which RKIP suppresses metastasis and hopefully identify specific targets to inhibit metastasis. [unreadable] [unreadable]..
  18. DEVELOPMENT OF MATURE ZEBRAFISH AS AN ANIMAL MODEL
    Evan Keller; Fiscal Year: 2006
    ....
  19. Overexpression of membrane proteins in Tetrahymena
    THEODORE CLARK; Fiscal Year: 2006
    ..The technology described here is intended to better understand how these proteins function, leading ultimately to strategies for the treatment of serious disorders ranging from cancer to stoke. [unreadable] [unreadable]..
  20. In vitro refinements for Cryptosporidium parvum
    STEVE UPTON; Fiscal Year: 2003
    ..abstract_text> ..
  21. ETHANOL MEDIATED OSTEOPOROSIS AND INTERLEUKIN 6
    Evan Keller; Fiscal Year: 2002
    ....