canine hip dysplasia

Summary

Summary: A hereditary disease of the hip joints in dogs. Signs of the disease may be evident any time after 4 weeks of age.

Top Publications

  1. pmc The femoral head and neck ostectomy
    Greg Harasen
    Animal Clinic of Regina, 1800 Garnet Street, Regina, Saskatchewan S4T 2Z2
    Can Vet J 45:163-4. 2004
  2. ncbi Repeatability and reproducibility of distraction indices in PennHIP examinations of the hip joint in dogs
    M M D Ginja
    Department of Veterinary Sciences CETAV, University of Tras os Montes e Alto Douro, Portugal
    Acta Vet Hung 54:387-92. 2006
  3. ncbi Sciatic neurapraxia as a complication in 1000 consecutive canine total hip replacements
    Chad M Andrews
    Gulf Coast Veterinary Specialists, Houston, TX 77027, USA
    Vet Surg 37:254-62. 2008
  4. ncbi Puppy line, metaphyseal sclerosis, and caudolateral curvilinear and circumferential femoral head osteophytes in early detection of canine hip dysplasia
    Amanda Risler
    College of Agricultural and Life Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI 53706, USA
    Vet Radiol Ultrasound 50:157-66. 2009
  5. ncbi Estimation of heritabilities, genetic correlations, and breeding values of four traits that collectively define hip dysplasia in dogs
    Zhiwu Zhang
    Institute for Genomic Diversity, College of Veterinary Medicine, Cornell University, Ithaca, NY 14850, USA
    Am J Vet Res 70:483-92. 2009
  6. ncbi Complex segregation analysis of canine hip dysplasia in German shepherd dogs
    V Janutta
    Institute for Animal Breeding and Genetics, University of Veterinary Medicine Hannover, Foundation, Bunteweg 17p, 30559 Hannover, Germany
    J Hered 97:13-20. 2006
  7. ncbi Diagnosis, genetic control and preventive management of canine hip dysplasia: a review
    M M D Ginja
    Department of Veterinary Science CITAB, University of Tras os Montes e Alto Douro, 5001 801 Vila Real, Portugal
    Vet J 184:269-76. 2010
  8. ncbi Mapping quantitative trait loci for canine hip dysplasia in German Shepherd dogs
    Yvonne Marschall
    Institute for Animal Breeding and Genetics, University of Veterinary Medicine, Bünteweg 17 p, 30559, Hannover, Germany
    Mamm Genome 18:861-70. 2007
  9. ncbi Genetic structure of susceptibility traits for hip dysplasia and microsatellite informativeness of an outcrossed canine pedigree
    R J Todhunter
    Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14850, USA
    J Hered 94:39-48. 2003
  10. ncbi Prevalence of canine hip dysplasia in a veterinary teaching hospital population
    J L Rettenmaier
    Veterinary Services, Columbia, MO 65201, USA
    Vet Radiol Ultrasound 43:313-8. 2002

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Scientific Experts

Detail Information

Publications146 found, 100 shown here

  1. pmc The femoral head and neck ostectomy
    Greg Harasen
    Animal Clinic of Regina, 1800 Garnet Street, Regina, Saskatchewan S4T 2Z2
    Can Vet J 45:163-4. 2004
  2. ncbi Repeatability and reproducibility of distraction indices in PennHIP examinations of the hip joint in dogs
    M M D Ginja
    Department of Veterinary Sciences CETAV, University of Tras os Montes e Alto Douro, Portugal
    Acta Vet Hung 54:387-92. 2006
    ..Distraction indices measured in different PennHIP studies, using this DI measurement method and performed by trained researchers, can be considered interchangeable...
  3. ncbi Sciatic neurapraxia as a complication in 1000 consecutive canine total hip replacements
    Chad M Andrews
    Gulf Coast Veterinary Specialists, Houston, TX 77027, USA
    Vet Surg 37:254-62. 2008
    ..To report the frequency of sciatic neurapraxia (SN) associated with total hip replacement (THR), to determine outcome (recovery rate) after SN associated with THR, and to identify potential causes of THR-associated SN in dogs...
  4. ncbi Puppy line, metaphyseal sclerosis, and caudolateral curvilinear and circumferential femoral head osteophytes in early detection of canine hip dysplasia
    Amanda Risler
    College of Agricultural and Life Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI 53706, USA
    Vet Radiol Ultrasound 50:157-66. 2009
    ..risk (Greyhounds) and high risk (Foxhounds) of developing early degenerative joint disease associated with canine hip dysplasia. Though 44% of Greyhound hips had puppy lines and 28% had femoral metaphyseal sclerosis at 15-17 weeks of ..
  5. ncbi Estimation of heritabilities, genetic correlations, and breeding values of four traits that collectively define hip dysplasia in dogs
    Zhiwu Zhang
    Institute for Genomic Diversity, College of Veterinary Medicine, Cornell University, Ithaca, NY 14850, USA
    Am J Vet Res 70:483-92. 2009
    ....
  6. ncbi Complex segregation analysis of canine hip dysplasia in German shepherd dogs
    V Janutta
    Institute for Animal Breeding and Genetics, University of Veterinary Medicine Hannover, Foundation, Bunteweg 17p, 30559 Hannover, Germany
    J Hered 97:13-20. 2006
    Complex segregation analyses were carried out to clarify the mode of inheritance of canine hip dysplasia (CHD) in German shepherd dogs. Data were used from 8,567 animals examined for CHD from 20 families with three to four generations...
  7. ncbi Diagnosis, genetic control and preventive management of canine hip dysplasia: a review
    M M D Ginja
    Department of Veterinary Science CITAB, University of Tras os Montes e Alto Douro, 5001 801 Vila Real, Portugal
    Vet J 184:269-76. 2010
    ..The implementation of breeding programmes based on BVs and further research into early prediction/diagnosis of HD and effective preventive treatment approaches are essential...
  8. ncbi Mapping quantitative trait loci for canine hip dysplasia in German Shepherd dogs
    Yvonne Marschall
    Institute for Animal Breeding and Genetics, University of Veterinary Medicine, Bünteweg 17 p, 30559, Hannover, Germany
    Mamm Genome 18:861-70. 2007
    b>Canine hip dysplasia (CHD) is a common hereditary developmental disease of the coxofemoral joints. CHD is characterized by subluxation of the femoral head and deformation of the acetabulum leading to a painful osteoarthrosis...
  9. ncbi Genetic structure of susceptibility traits for hip dysplasia and microsatellite informativeness of an outcrossed canine pedigree
    R J Todhunter
    Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14850, USA
    J Hered 94:39-48. 2003
    ..When combined with previous power and quantitative genetic analyses, these estimates indicate that this pedigree is informative for QTL mapping of hip dysplasia traits...
  10. ncbi Prevalence of canine hip dysplasia in a veterinary teaching hospital population
    J L Rettenmaier
    Veterinary Services, Columbia, MO 65201, USA
    Vet Radiol Ultrasound 43:313-8. 2002
    ..16; P = 0.29). Degenerative joint disease (DJD) was the most common radiographic manifestation of HD and there appeared to be a threshold at 12 months of age after which the presence of DJD was the primary diagnostic criteria...
  11. ncbi Inheritance of canine hip dysplasia: review of estimation methods and of heritability estimates and prospects on further developments
    V Janutta
    Institute for Animal Breeding and Genetics, University of Veterinary Medicine Hannover, Foundation, Germany
    Dtsch Tierarztl Wochenschr 113:6-12. 2006
    b>Canine hip dysplasia is a long-known, widespread degenerative skeletal disease...
  12. ncbi Canine hip dysplasia treated by juvenile pubic symphysiodesis. Part I: two year results of computed tomography and distraction index
    R T Dueland
    Department of Surgical Sciences, University of Wisconsin, Madison, Wisconsin, USA
    Vet Comp Orthop Traumatol 23:306-17. 2010
    ..measure one and two year effects of juvenile pubic symphysiodesis (JPS) in puppies defined as 'at-risk' for canine hip dysplasia (CHD) using the following objective hip conformation criteria: Acetabular angle (AA), dorsal acetabular rim ..
  13. ncbi Canine hip dysplasia treated by juvenile pubic symphysiodesis. Part II: two year clinical results
    R T Dueland
    Department of Surgical Sciences, University of Wisconsin, Madison, Wisconsin, USA
    Vet Comp Orthop Traumatol 23:318-25. 2010
    ..To determine the clinical effects of juvenile pubic symphysiodesis (JPS) treatment in hip dysplasia-prone puppies with comparison to similar untreated control puppies...
  14. ncbi Simultaneous bilateral femoral head and neck ostectomy for the treatment of canine hip dysplasia
    Elizabeth A Rawson
    Veterinary Specialists of South Florida, Cooper City, Florida 33024, USA
    J Am Anim Hosp Assoc 41:166-70. 2005
    ..Simultaneous bilateral FHO was a viable surgical option for the treatment of painful bilateral hip disease in dogs, especially when other surgical options were not indicated or were cost prohibitive...
  15. ncbi A retrospective study of canine hip dysplasia in 116 military working dogs. Part I: Angle measurements and orthopedic foundation for animals (OFA) grading
    C M Banfield
    Department of Defense Military Working Dog Veterinary Services, Lackland Air Force Base, San Antonio, Texas 78236 5631, USA
    J Am Anim Hosp Assoc 32:413-22. 1996
    ..0001). Angles of inclination and joint space width measurements did not demonstrate a correlation to canine hip dysplasia. Dysplastic dogs had a significant estimated risk for development of DJD compared to normal dogs (p less ..
  16. ncbi Selection for breed-specific long-bodied phenotypes is associated with increased expression of canine hip dysplasia
    Taryn Roberts
    Faculty of Veterinary Science Room 206, B19, University of Sydney, NSW 2006, Australia
    Vet J 183:266-72. 2010
    ....
  17. ncbi Estimates of prevalence of hip dysplasia in Golden Retrievers and Rottweilers and the influence of bias on published prevalence figures
    Erin R Paster
    Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104 6010, USA
    J Am Vet Med Assoc 226:387-92. 2005
    To estimate prevalence of canine hip dysplasia (CHD) in Golden Retrievers and Rottweilers and identify sources of bias in published reports.
  18. ncbi Evaluation of risk factors for degenerative joint disease associated with hip dysplasia in German Shepherd Dogs, Golden Retrievers, Labrador Retrievers, and Rottweilers
    G K Smith
    Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia 19104, USA
    J Am Vet Med Assoc 219:1719-24. 2001
    ..This association was breed-specific, indicating that breed-specific information on disease susceptibility should be incorporated when making breeding decisions and when deciding on possible surgical treatment of hip dysplasia...
  19. ncbi Biomarkers of joint tissue metabolism in canine osteoarthritic and arthritic joint disorders
    N Hegemann
    Institute of Immunology and Molecular Biology, Faculty of Veterinary Medicine, Free University of Berlin, Germany
    Osteoarthritis Cartilage 10:714-21. 2002
    ..To explore the levels of matrix metalloprotease-3 (MMP-3), tissue inhibitor of metalloproteases-1 (TIMP-1), 5D4 keratan sulfate, and two 3B3 chondroitin-sulfate epitopes in several canine osteoarthritic and inflammatory arthropathies...
  20. pmc Evaluation of serum chondroitin sulfate and hyaluronan: biomarkers for osteoarthritis in canine hip dysplasia
    Korakot Nganvongpanit
    Department of Veterinary Preclinical Science, Faculty of Veterinary Medicine, Chiang Mai University, Chiang Mai 50100, Thailand
    J Vet Sci 9:317-25. 2008
    ..74 +/- 59.71 ng/ml) was lower than that in the non HD group (245.45 +/- 97.84 ng/ml) (p < 0.05). The results indicate that the serum CS and HA levels might be used as biomarkers for osteoarthritis in HD dogs...
  21. ncbi Effect of month of birth on hip dysplasia in labrador retrievers and Gordon setters
    J L N Wood
    Epidemiology Unit, Animal Health Trust, Lanwades Park, Kentford, Newmarket, Suffolk CB8 7UU
    Vet Rec 152:69-72. 2003
    ..Enlarging the model by including its age when examined made it possible to quantify the significant genetic parental effects and the effects of the animal's month of birth and its age when examined...
  22. ncbi A random model for mapping imprinted quantitative trait loci in a structured pedigree: an implication for mapping canine hip dysplasia
    Tian Liu
    Department of Statistics, University of Florida, Gainesville, FL 32611, USA
    Genomics 90:276-84. 2007
    ..The model was employed to map iQTL responsible for canine hip dysplasia in a multihierarchical canine pedigree, founded with seven greyhounds and six Labrador retrievers...
  23. ncbi Heritability of canine hip-dysplasia score and its components in Gordon setters
    J L Wood
    Animal Health Trust, Lanwades Park, Kentford, Suffolk, CB8 7UU, Newmarket, UK
    Prev Vet Med 46:87-97. 2000
    ..The models reported here provide quantitative predictions of likely health benefits from selective breeding...
  24. ncbi Heritability and epidemiology of canine hip-dysplasia score in flat-coated retrievers and Newfoundlands in the United Kingdom
    J L Wood
    Animal Health Trust, Epidemiology Unit, Lanwades Park, Kentford, Suffolk CB8 7UU, Newmarket, UK
    Prev Vet Med 46:75-86. 2000
    ..The breeders in UK tended to use healthy sires for breeding but they have taken less care in selecting dams. Our regression models emphasise the need for both sires and dams, particularly dams, to be healthy with very small hip scores...
  25. ncbi Genetic and phenotypic trends in canine hip dysplasia in the German population of German shepherd dogs
    Verena Janutta
    Institute for Animal Breeding and Genetics, University of Veterinary Medicine Hannover
    Berl Munch Tierarztl Wochenschr 121:102-9. 2008
    ..in 157,455 German shepherd dogs of the German population born between 1985 and 2003 which were Xrayed for canine hip dysplasia (CHD)...
  26. ncbi Laxity of canine hip joint in two positions with computed tomography
    Makoto Fujiki
    Department of Veterinary Surgery, Kagoshima University, Korimoto, Japan
    J Vet Med Sci 66:1003-6. 2004
    ..Further, CT scanning in the weight-bearing position was more sensitive than in the normal-standing position for the detection of laxity in hips with normal or only slightly abnormal DARA...
  27. ncbi Use of the caudolateral curvilinear osteophyte as an early marker for future development of osteoarthritis associated with hip dysplasia in dogs
    Michelle Y Powers
    Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104 6010, USA
    J Am Vet Med Assoc 225:233-7. 2004
    ..To determine the relationship between the caudolateral curvilinear osteophyte (CCO) and osteoarthritis associated with hip dysplasia in dogs...
  28. ncbi Double-blind, placebo-controlled trial of the pain-relieving effects of the implantation of gold beads into dogs with hip dysplasia
    G T Jaeger
    Department of Companion Animal Clinical Sciences, Norwegian School of Veterinary Science, PO Box 8146 Dep, N 0033 Oslo, Norway
    Vet Rec 158:722-6. 2006
    ..There were significantly greater improvements in mobility and greater reductions in the signs of pain in the dogs treated with gold implantation than in the placebo group. The veterinarian's and the owners' assessments corresponded well...
  29. ncbi Early hip laxity examination in predicting moderate and severe hip dysplasia in Estrela mountain dog
    M M D Ginja
    Department of Veterinary Science CITAB, University of Tras os Montes e Alto Douro, Vila Real, Portugal
    J Small Anim Pract 49:641-6. 2008
    ..To determine the reliability of early passive hip laxity examination in predicting moderate and severe hip dysplasia...
  30. ncbi Update of a retrospective cohort study of changes in hip joint phenotype of dogs evaluated by the OFA in the United States, 1989-2003
    John B Kaneene
    Center for Comparative Epidemiology and the Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, MI 48824 1314, USA
    Vet Surg 38:398-405. 2009
    ....
  31. pmc The long (and winding) road to gene discovery for canine hip dysplasia
    Lan Zhu
    Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Vet J 181:97-110. 2009
    ....
  32. ncbi Evaluation of a radiographic caudolateral curvilinear osteophyte on the femoral neck and its relationship to degenerative joint disease and distraction index in dogs
    Philipp D Mayhew
    Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia 19104 6010, USA
    J Am Vet Med Assoc 220:472-6. 2002
    ....
  33. ncbi Controlling canine hip dysplasia in Finland
    M Leppanen
    Department of Clinical Veterinary Science Animal Hygiene, University of Helsinki, Yliopisto, Finland
    Prev Vet Med 42:121-31. 1999
    ..Modern society has high demands for animal welfare and consumer issues, and breeders and kennel societies should pay more attention to health issues in breeding pedigreed dogs...
  34. ncbi Juvenile pubic symphysiodesis in dysplastic puppies at 15 and 20 weeks of age
    Alison J Patricelli
    Department of Surgical Sciences, School of Veterinary Medicine, University of Wisconsin Madison, Madison, WI, USA
    Vet Surg 31:435-44. 2002
    ..To examine the effects of juvenile pubic symphysiodesis (JPS) on hip joint conformation, hip laxity, gait, and the development of degenerative joint disease (DJD) in dysplastic puppies operated at 15 and 20 weeks of age...
  35. ncbi Quantitative evaluation of hip joint laxity in 22 Border Collies using computed tomography
    Miori Kishimoto
    Department of Clinical Veterinary Science, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido, Japan
    J Vet Med Sci 71:247-50. 2009
    ..We consider CT evaluation in a weight-bearing position to be a useful method for multidirectional evaluation of hips...
  36. pmc Stratification, blinding and placebo effect in a randomized, double blind placebo-controlled clinical trial of gold bead implantation in dogs with hip dysplasia
    G T Jaeger
    Department of Companion Animal Clinical Sciences, Norwegian School of Veterinary Science, Oslo, Norway
    Acta Vet Scand 46:57-68. 2005
    ..Eighty dogs with canine hip dysplasia (CHD) were included in a randomized, placebo-controlled and double blind clinical trial with stratified ..
  37. ncbi Double-blind evaluation of implants of gold wire at acupuncture points in the dog as a treatment for osteoarthritis induced by hip dysplasia
    A Hielm-Bjorkman
    Faculty of Veterinary Medicine, Department of Clinical Sciences, University of Helsinki, Finland
    Vet Rec 149:452-6. 2001
    ..0001 and P=0.0034 for the owners' evaluation of locomotion and pain, respectively), there were no statistically significant differences between the treated and control groups (P=0.19 and P=0.41, P=0.24, respectively)...
  38. ncbi Ground reaction force analysis of unilateral coxofemoral denervation for the treatment of canine hip dysplasia
    S A Lister
    College of Veterinary Medicine, Kansas State University, Manhattan, Kansas 66506, USA
    Vet Comp Orthop Traumatol 22:137-41. 2009
    ..Longer follow-up would be required in improved dogs in order to document continued efficacy...
  39. ncbi Passive hip laxity in Estrela Mountain Dog--distraction index, heritability and breeding values
    Mário M D Ginja
    Department of Veterinary Sciences CITAB, University of Tras os Montes e Alto Douro, Portugal
    Acta Vet Hung 56:303-12. 2008
    ..The data confirm high PHL in breeds with high prevalence and severity of canine hip dysplasia. The high heritability indicates that the DI could be reduced in the breed if PHL were used as a selection ..
  40. ncbi Quantitative trait loci for hip dysplasia in a cross-breed canine pedigree
    Rory J Todhunter
    Department of Clinical Sciences, Box 32 College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA
    Mamm Genome 16:720-30. 2005
    b>Canine hip dysplasia is a common developmental inherited trait characterized by hip laxity, subluxation or incongruity of the femoral head and acetabulum in affected hips...
  41. ncbi Canine hip dysplasia radiographic screening. Prevalence of rotation of the pelvis along its length axis in 7,012 conventional hip extended radiographs
    J P Genevois
    Small Animal Department, Surgery, School of Veterinary Medicine, Lyon, France
    Vet Comp Orthop Traumatol 20:296-8. 2007
    ..2%. The consequences of the pelvis rotation on the Norberg-Olsson angle, on the dorsal femoral head coverage, and in the aspect of cranial acetabular edge have to be taken into account when scoring the dog for hip dysplasia...
  42. ncbi Developmental orthopedic disease
    Jennifer Demko
    Department of Clinical Sciences, College of Veterinary Medicine, Mississippi State University, Mississippi State, MS 39762, USA
    Vet Clin North Am Small Anim Pract 35:1111-35, v. 2005
    ....
  43. ncbi Evaluation of a circumferential femoral head osteophyte as an early indicator of osteoarthritis characteristic of canine hip dysplasia in dogs
    Stephanie D Szabo
    Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104 6010, USA
    J Am Vet Med Assoc 231:889-92. 2007
    ..the relationship between a circumferential femoral head osteophyte (CFHO) and osteoarthritis characteristic of canine hip dysplasia, and to ascertain whether CFHO, like osteoarthritis, varies between diet-restricted and control-fed dogs.
  44. ncbi What is your diagnosis? Benign bone cysts
    Tiffany J MacInnes
    Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville 32610 0126, USA
    J Am Vet Med Assoc 227:1561-2. 2005
  45. ncbi BVA/KC hip and elbow dysplasia schemes
    John E F Houlton
    Vet Rec 157:853. 2005
  46. ncbi Comparison of estimates of hip dysplasia genetic parameters in Estrela Mountain Dog using linear and threshold models
    A M Silvestre
    Department of Animal Science CECAV, University of Tras os Montes e Alto Douro, 5001 801 Vila Real, Portugal
    J Anim Sci 85:1880-4. 2007
    ..were individually scored, according to the Fédération Cynologic Internationale grading rules of the canine hip dysplasia system, as normal (1), borderline (2), slight (3), moderate (4), and severe (5 and 6)...
  47. ncbi Retrospective evaluation of the long-term outcome of non-surgical management of 74 dogs with clinical hip dysplasia
    M Farrell
    Department of Veterinary Clinical Studies, University of Glasgow, Bearsden Road, Glasgow
    Vet Rec 160:506-11. 2007
    The long-term outcome for dogs treated non-surgically for clinical signs of canine hip dysplasia were evaluated retrospectively; 74 dogs were evaluated by a postal questionnaire sent to their owners, and 24 of these were also evaluated by ..
  48. ncbi Technical note: Use of marker-based relationships with multiple-trait derivative-free restricted maximal likelihood
    Z Zhang
    Institute for Genetic Diversity, Cornell University, Ithaca, NY 14853, USA
    J Anim Sci 85:881-5. 2007
    ..The strategy behind this modification and its design is described. An application is illustrated in a QTL association study for canine hip dysplasia.
  49. ncbi Lifelong diet restriction and radiographic evidence of osteoarthritis of the hip joint in dogs
    Gail K Smith
    Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, 19104 6010, USA
    J Am Vet Med Assoc 229:690-3. 2006
    ..To evaluate the effects of diet restriction on development of radiographic evidence of hip joint osteoarthritis in dogs...
  50. ncbi Radiographic evaluation of the Zurich cementless total hip acetabular component
    Steven P Hanson
    Affiliated Veterinary Specialists PA and Central Florida Veterinary Radiology PA, Maitland, 32751, USA
    Vet Surg 35:550-8. 2006
    ..To radiographically evaluate the Zurich cementless total hip (ZCTH) cup and correlate lucency with clinical signs of implant instability, time since surgery, and implant generation, using zonal analysis...
  51. pmc Modeling extent and distribution of zygotic disequilibrium: implications for a multigenerational canine pedigree
    Tian Liu
    Department of Statistics, University of Florida, Gainesville, Florida 32611, USA
    Genetics 174:439-53. 2006
    ..The results from this study provide scientific guidance about the determination of the number of markers used for whole-genome association studies...
  52. ncbi Risk factors for ventral luxation in canine total hip replacement
    Laura L Nelson
    Department of Veterinary Clinical Sciences, Veterinary Hospital, The Ohio State University, Columbus, OH 43212, USA
    Vet Surg 36:644-53. 2007
    ..To identify risk factors associated with ventral luxation (VL) of canine total hip replacement (THR), and outcome...
  53. ncbi Evaluation of the Norberg angle threshold: a comparison of Norberg angle and distraction index as measures of coxofemoral degenerative joint disease susceptibility in seven breeds of dogs
    William T N Culp
    Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA
    Vet Surg 35:453-9. 2006
    ..To evaluate the thresholds of 2 radiographic methods used to determine coxofemoral joint laxity in 7 breeds of dogs...
  54. ncbi Heritability and epidemiology of canine hip-dysplasia score and its components in Labrador retrievers in the United Kingdom
    J L N Wood
    Animal Health Trust, Lanwades Park, Newmarket, Kentford CB8 7UU, Suffolk, UK
    Prev Vet Med 55:95-108. 2002
    ..Offspring hip score could be reduced substantially by using only parents with zero hip score...
  55. pmc Bilaterally asymmetric effects of quantitative trait loci (QTLs): QTLs that affect laxity in the right versus left coxofemoral (hip) joints of the dog (Canis familiaris)
    Kevin Chase
    Department of Biology, University of Utah, Salt Lake City, Utah 84102, USA
    Am J Med Genet A 124:239-47. 2004
    ..The other, associated with FH2598, was significant for the right but not the left hip. For both QTLs, some extreme phenotypes were best explained by specific interactions between haplotypes...
  56. ncbi Comparison of three distraction methods and conventional radiography for early diagnosis of canine hip dysplasia
    S Ohlerth
    Section of Radiology, Department of Veterinary Clinical Sciences, University of Bern, Langgasse 124, 3001 Bern, Switzerland
    J Small Anim Pract 44:524-9. 2003
    ..Both the PennHip and lath method were also clinically reliable techniques in predicting true negatives. The ultrasonographic distraction method was moderately reliable...
  57. ncbi Effects of postoperative administration of ketoprofen or carprofen on short- and long-term results of femoral head and neck excision in dogs
    Emmanuelle Grisneaux
    Departement de Sciences Cliniques, Faculte de Medecine Veterinaire, Universite de Montreal, Saint Hyacinthe, QC, Canada J2S 7C6
    J Am Vet Med Assoc 223:1006-12. 2003
    ..To determine whether postoperative administration of ketoprofen or carprofen had any effects on short- or long-term results of femoral head and neck excision (FHNE) in dogs...
  58. ncbi Volume of the ligamentum capitis femoris in osteoarthritic hip joints of adult dogs
    J D Mande
    Department of Clinical Studies, Faculty of Veterinary Medicine, University of Nairobi, PO Box 29053, Nairobi, Kenya
    J S Afr Vet Assoc 74:11-3. 2003
    ..Assessment of the volume of the ligamentum capitis femoris revealed that it is an important tool for research in canine hip dysplasia and osteoarthritis.
  59. ncbi Effect of dorsal hip loading, sedation, and general anesthesia on the dorsolateral subluxation score in dogs
    Rory J Todhunter
    Departments of Clinical Sciences and Population Medicine and Diagnostic Sciences and the James A Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Vet Surg 32:196-205. 2003
    ..To determine whether dorsal loading of the pelvis and type of chemical restraint affected the dorsolateral subluxation (DLS) score of dog hips. STYDY DESIGN: In vivo testing of diagnostic method...
  60. ncbi Power of a Labrador Retriever-Greyhound pedigree for linkage analysis of hip dysplasia and osteoarthritis
    Rory J Todhunter
    Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Am J Vet Res 64:418-24. 2003
    ..To estimate the number of dogs required to find linkage to heritable traits of hip dysplasia in dogs from an experimental pedigree...
  61. ncbi Positive intraoperative cultures and canine total hip replacement: risk factors, periprosthetic infection, and surgical success
    Karla C L Lee
    Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia 19104 6010, USA
    J Am Anim Hosp Assoc 38:271-8. 2002
    ..The duration of the clinical signs of hip disease prior to THR was significantly greater for those cases with a positive culture (P=0.034). The incidence of positive cultures was not related to surgical success...
  62. ncbi Breed susceptibility for developmental orthopedic diseases in dogs
    Elizabeth LaFond
    Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Purdue University, West Lafayette, Indiana 47907, USA
    J Am Anim Hosp Assoc 38:467-77. 2002
    ..Developmental orthopedic diseases investigated included canine hip dysplasia (CHD); craniomandibular osteopathy (CMO); fragmented coronoid process; hypertrophic osteodystrophy; Legg-..
  63. ncbi Hip dysplasia in labrador retrievers: the effects of age at scoring
    J L N Wood
    Epidemiology Unit, Animal Health Trust, Lanwades Park, Kentford, Newmarket, Suffolk CB8 7UU
    Vet Rec 152:37-40. 2003
    ..The mean hip score of the dogs was positively and significantly correlated with their age. If this relationship with age is ignored, various offspring/parental relationships and the estimates of heritability are likely to be distorted...
  64. ncbi The effect of stem length on femoral component positioning in canine total hip arthroplasty
    Michael G Dearmin
    Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California Davis, One Shields Avenue, Davis, CA 95616, USA
    Vet Surg 33:272-8. 2004
    ..To determine the effects of femoral prosthesis stem length on positioning of the femoral component within the canine femur...
  65. ncbi An epidemiological approach to prevention and control of three common heritable diseases in canine pedigree breeds in the United Kingdom
    J L N Wood
    Animal Health Trust, Lanwades Park, Kentford, Newmarket, Suffolk CB8 7UU, UK
    Vet J 168:14-27. 2004
    ..Insight, even for these complex diseases, can be derived from further detailed statistical evaluation of datasets such as those described in this paper...
  66. ncbi Comparison of femoral inclination angle measurements in dysplastic and nondysplastic dogs of different breeds
    M Sarierler
    Department of Surgery, Faculty of Veterinary Medicine, University of Adnan Menderes, 09016 Aydin, Turkey
    Acta Vet Hung 52:245-52. 2004
    ..001). Age and sex did not affect the femoral neck angle...
  67. ncbi Incidence, risk factors, and heritability estimates of hind limb lameness caused by hip dysplasia in a birth cohort of boxers
    Marjan A E van Hagen
    Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, P O Box 80154, 3508 TD Utrecht, The Netherlands
    Am J Vet Res 66:307-12. 2005
    ..To determine incidence, risk factors, and heritability estimates of hind limb lameness caused by hip dysplasia in a birth cohort of Boxers...
  68. ncbi A prospective study on canine hip dysplasia and growth in a cohort of four large breeds in Norway (1998-2001)
    Randi I Krontveit
    Department of Companion Animal Clinical Sciences, Norwegian School of Veterinary Science, P O Box 8146 Dep, N 0033 Oslo, Norway
    Prev Vet Med 97:252-63. 2010
    ..was to measure the effect of weight and growth related parameters on the risk of development of Canine Hip Dysplasia (CHD)...
  69. pmc Retrospective analysis for genetic improvement of hip joints of cohort labrador retrievers in the United States: 1970-2007
    Yali Hou
    College of Animal Science and Technology, China Agricultural University, Beijing, China
    PLoS ONE 5:e9410. 2010
    b>Canine Hip Dysplasia (CHD) is a common inherited disease that affects dog wellbeing and causes a heavy financial and emotional burden to dog owners and breeders due to secondary hip osteoarthritis...
  70. ncbi Inflammation-responsive transcription factors SAF-1 and c-Jun/c-Fos promote canine MMP-1 gene expression
    Alpana Ray
    Department of Veterinary Pathobiology, University of Missouri, Columbia, MO 65211, USA
    Biochim Biophys Acta 1732:53-61. 2005
    ..b>Canine hip dysplasia, a developmental orthopedic disease which results in arthritic condition as is seen in human OA is an ..
  71. pmc Differential genetic regulation of canine hip dysplasia and osteoarthritis
    Zhengkui Zhou
    College of Animal Science and Technology, Northwest A and F University, Yangling, China
    PLoS ONE 5:e13219. 2010
    b>Canine hip dysplasia (HD) is a common polygenic trait characterized by hip malformation that results in osteoarthritis (OA). The condition in dogs is very similar to developmental dysplasia of the human hip which also leads to OA.
  72. ncbi An outcrossed canine pedigree for linkage analysis of hip dysplasia
    R J Todhunter
    Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    J Hered 90:83-92. 1999
    b>Canine hip dysplasia (CHD) is a prevalent, debilitating, polygenic disease characterized by hip subluxation and laxity which results in osteoarthritis. We are developing an informative pedigree for linkage analysis of CHD...
  73. ncbi Juvenile pubic symphysiodesis and juvenile pubic symphysiodesis associated with pectineus myotomy: short-term outcome in 56 dysplastic puppies
    Antoine Bernardé
    Clinique Vétérinaire des Quais, Blois, France
    Vet Surg 39:158-64. 2010
    ....
  74. ncbi Effects of pubic symphysiodesis in dysplastic puppies
    R T Dueland
    Department of Surgical Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI 53706, USA
    Vet Surg 30:201-17. 2001
    ..CLINICAL SIGNIFICANCE--Dysplastic hips in young dogs were significantly improved by JPS...
  75. ncbi Evaluation of methods for assessment of pain associated with chronic osteoarthritis in dogs
    Anna K Hielm-Björkman
    Department of Clinical Veterinary Sciences, Faculty of Veterinary Medicine, University of Helsinki, Finland FIN 00014
    J Am Vet Med Assoc 222:1552-8. 2003
    ..To identify variables and evaluate methods for assessing chronic pain in dogs...
  76. ncbi The effects of positioning, reason for screening and the referring veterinarian on prevalence estimates of canine hip dysplasia
    B J G Broeckx
    Laboratory of Pharmaceutical Biotechnology, Faculty of Pharmaceutical Sciences, Ghent University, Harelbekestraat 72, 9000 Ghent, Belgium
    Vet J 201:378-84. 2014
    Although the prevalence of canine hip dysplasia (HD) has been the subject of a number of published studies, estimates vary widely. This study evaluated several possible causes for these differences...
  77. pmc Genome wide analysis indicates genes for basement membrane and cartilage matrix proteins as candidates for hip dysplasia in Labrador Retrievers
    Ineke C M Lavrijsen
    Department of Clinical Sciences of Companion Animal, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands
    PLoS ONE 9:e87735. 2014
    ..b>Canine hip dysplasia is considered multifactorial and polygenic, and a variety of chromosomal regions have been associated with ..
  78. ncbi Risk of simultaneous phenotypic expression of hip and elbow dysplasia in dogs: a study of 1,411 radiographic examinations sent for official scoring
    T Cachon
    Ecole Nationale Veterinaire de Lyon, Surgery, Small Animal Department, Marcy l Etoile, France
    Vet Comp Orthop Traumatol 23:28-30. 2010
    ..Due to the low, yet positive correlation, selection against one trait will not affect the other trait sufficiently. Therefore selection has to be conducted at reduction of HD as well as reduction of ED...
  79. ncbi Effect of adipose-derived mesenchymal stem and regenerative cells on lameness in dogs with chronic osteoarthritis of the coxofemoral joints: a randomized, double-blinded, multicenter, controlled trial
    Linda L Black
    Vet Stem, Inc, Poway, CA 92064, USA
    Vet Ther 8:272-84. 2007
    ..This is the first randomized, blinded, placebo-controlled clinical trial reporting on the effectiveness of stem cell therapy in dogs...
  80. ncbi Evaluation of a fibrillin 2 gene haplotype associated with hip dysplasia and incipient osteoarthritis in dogs
    Steven G Friedenberg
    Department of Clinical Sciences, College of Arts and Sciences, Oklahoma State University, Stillwater, OK 74078, USA
    Am J Vet Res 72:530-40. 2011
    To determine whether a mutation in the fibrillin 2 gene (FBN2) is associated with canine hip dysplasia (CHD) and osteoarthritis in dogs.
  81. ncbi Total hip replacement in a dog
    Nam Soo Kim
    Department of Surgery and Radiology, College of Veterinary Medicine, Chonbuk National University, Jeonju, Korea
    J Vet Sci 6:169-71. 2005
    ..THR resulted in satisfactory clinical functions with 6 months follow up and no complications were observed. Canine modular THR could be a successful modality for the management of disabling conditions of the coxofemoral joint...
  82. ncbi Mechanical devices to help in PennHIP examination
    M M D Ginja
    Department of Veterinary Science CETAV, University of Tras os Montes e Alto Douro, 5001 801 Vila Real, Portugal
    Acta Vet Hung 55:199-205. 2007
    ..7 +/- 1.2 (mean +/- SD) for MPP and SPM, respectively. In conclusion, the MPP needs fewer EIXXR than the SPM and complies with the new recommendations in X-ray protection, which introduce the ALARA (as-low-as-reasonably-achievable) idea...
  83. ncbi BVA/KC Hip and Elbow Dysplasia Schemes
    John Houlton
    Vet Rec 154:31. 2004
  84. ncbi A systematic review of the literature describing the efficacy of surgical treatments for canine hip dysplasia (1948-2012)
    Mary Sarah Bergh
    Department of Veterinary Clinical Sciences, Iowa State University College of Veterinary Medicine, Ames, Iowa
    Vet Surg 43:501-6. 2014
    To systematically evaluate the literature reporting outcome of surgical treatments for canine hip dysplasia (CHD) and to evaluate whether adequate evidence exists to support a procedure that will allow a consistent return to normal ..
  85. ncbi Morphometric assessment of the canine hip joint using the dorsal acetabular rim view and the centre-edge angle
    L Meomartino
    Centro di Radiologia Veterinaria, Dipartimento di Scienze Cliniche Veterinarie, Facolta di Medicina Veterinaria, Universita degli Studi di Napoli Federico II, Italy
    J Small Anim Pract 43:2-6. 2002
    ..It is concluded that the CE angle is more reliable than the AS angle in the evaluation of acetabular coverage, and that the DAR view provides valuable data compared with the VD view alone in the early stages of canine hip dysplasia.
  86. ncbi The canine trochanteric fossa: a radiographic and anatomic study
    E M Frame
    Clinic of Radiology, University of Veterinary Medicine, Vienna, Austria
    Vet Radiol Ultrasound 42:297-304. 2001
    ..Dissection identified a small number of minor branches of the medial circumflex femoral artery entering these...
  87. pmc Estimated breeding values for canine hip dysplasia radiographic traits in a cohort of Australian German Shepherd dogs
    Bethany J Wilson
    Faculty of Veterinary Science, The University of Sydney, Sydney, New South Wales, Australia
    PLoS ONE 8:e77470. 2013
    b>Canine hip dysplasia (CHD) is a serious and common musculoskeletal disease of pedigree dogs and therefore represents both an important welfare concern and an imperative breeding priority...
  88. ncbi Isolation, characterization and molecular screening of canine SLC26A2 (sulphate transporter) in German Shepherd dogs with hip dysplasia
    Shin Aeh Lee
    Section of Internal Medicine, School of Veterinary Medicine, Kangwon National University, Chuncheon 200 701, Korea
    J Genet 86:285-8. 2007
  89. pmc Genetic correlations among canine hip dysplasia radiographic traits in a cohort of Australian German Shepherd Dogs, and implications for the design of a more effective genetic control program
    Bethany J Wilson
    Faculty of Veterinary Science, The University of Sydney, Sydney, New South Wales, Australia
    PLoS ONE 8:e78929. 2013
    b>Canine hip dysplasia (CHD) is a common musculoskeletal disease in pedigree dog populations...
  90. ncbi Worldwide screening for canine hip dysplasia: where are we now?
    Geert Verhoeven
    Europees Specialist Chirurgie Gezelschapsdieren, Ghent University, Medical Imaging and Orthopedics, Salisburylaan 133, Merelbeke, Belgium
    Vet Surg 41:10-9. 2012
    To critically review the different screening systems used for canine hip dysplasia (CHD) and their impact on the prevalence of the disease.
  91. pmc Interobserver repeatability of measurements on computed tomography images of lax canine hip joints from youth to maturity
    Mandi J Lopez
    Laboratory for Equine and Comparative Orthopedic Research, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA 70803, USA
    Vet Surg 38:920-6. 2009
    ..To determine interobserver repeatability of measurements on computed tomography (CT) images of lax canine hip joints at different ages and in the presence of degenerative joint disease at maturity...
  92. ncbi Results of single-session bilateral triple pelvic osteotomy with an eight-hole iliac bone plate in dogs: 95 cases (1996-1999)
    Frank Borostyankoi
    All Care Animal Referral Center, 18440 Amistad St, Fountain Valley, CA 92708, USA
    J Am Vet Med Assoc 222:54-9. 2003
    ..To evaluate feasibility of single-session bilateral triple pelvic osteotomy with 8-hole iliac bone plates in dogs with bilateral hip dysplasia...
  93. ncbi Selection against canine hip dysplasia: success or failure?
    Bethany Wilson
    Faculty of Veterinary Science, University of Sydney, NSW 2006, Australia
    Vet J 189:160-8. 2011
    b>Canine hip dysplasia (CHD) is a multifactorial skeletal disorder which is very common in pedigree dogs and represents a huge concern for canine welfare. Control schemes based on selective breeding have been in operation for decades...
  94. ncbi Static and dynamic ultrasonography for the early diagnosis of canine hip dysplasia
    A Fischer
    Department of Veterinary Clinical Sciences, Small Animal Clinic, Justus Liebig University, Frankfurter Straße 108, 35392 Giessen, Germany
    J Small Anim Pract 51:582-8. 2010
    To determine the feasibility of sonographical examination of hip joints in non-sedated puppies and to assess the value of static and dynamic ultrasonography for the early diagnosis of canine hip dysplasia (CHD).
  95. ncbi Hip dysplasia in Estrela mountain dogs: prevalence and genetic trends 1991-2005
    M M D Ginja
    Department of Veterinary Science CITAB, University of Tras os Montes e Alto Douro, 5001 801 Vila Real, Portugal
    Vet J 182:275-82. 2009
    ..It also confirms an initial favourable change in BVs that is a likely consequence of the voluntary radiographic hip-screening programme...
  96. ncbi [Multivariate genetic analysis of canine hip and elbow dysplasia as well as humeral osteochondrosis in the Bernese mountain dog]
    Peter Hartmann
    Institut für Tierzucht und Vererbungsforschung, Stiftung Tierarztliche Hochschule Hannover
    Berl Munch Tierarztl Wochenschr 123:488-95. 2010
    In the present study genetic parameters for canine hip dysplasia (CHD), canine elbow dysplasia (CED) and osteochondrosis dissecans of the humeral head (OCD) were analysed in Bernese mountain dogs...
  97. ncbi A radiological study of the incidence of unilateral canine hip dysplasia
    S Citi
    Department of Veterinary Clinical Sciences, University of Pisa, Italy
    Schweiz Arch Tierheilkd 147:173-8. 2005
    ..reviewed pelvic radiographs of 891 dogs in a retrospective study, to determine the incidence of Unilateral Canine Hip Dysplasia (UCHD). Results show that 149 (16.7%) dogs had UCHD...
  98. ncbi Relation of the Norberg angle and position of the femoral head centre to the dorsal acetabular edge in evaluation of canine hip dysplasia
    L Skurková
    Small Animal Clinic, Department of Surgery, Orthopaedics and Radiology, University of Veterinary Medicine and Pharmacy, Komenskeho 73, 041 81 Kosice, Slovakia
    Vet Comp Orthop Traumatol 23:433-8. 2010
    b>Canine hip dysplasia (CHD) is a locomotive-system disease in dogs, which in many countries is the target of screening programs aimed at reducing the prevalence of CHD among descendants of predisposed dog breeds...
  99. ncbi A retrospective study of canine hip dysplasia in 116 military working dogs. Part II: Clinical signs and performance data
    C M Banfield
    Department of Defense Military Working Dog Veterinary Services, Lackland Air Force Base, San Antonio, Texas 78236 5631, USA
    J Am Anim Hosp Assoc 32:423-30. 1996
    ..The mean months of work for normal and dysplastic dogs were evaluated using the Student's t-test. No significant difference was found in the total number of months worked between normal and dysplastic dogs (p greater than 0.05)...
  100. ncbi Interobserver agreement on the assessability of standard ventrodorsal hip-extended radiographs and its effect on agreement in the diagnosis of canine hip dysplasia and on routine FCI scoring
    Geert E C Verhoeven
    Department of Medical Imaging, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium
    Vet Radiol Ultrasound 50:259-63. 2009
    ..Therefore, the credibility of the FCI screening method for canine hip dysplasia, using the standard hip-extended radiographic view, as currently applied in most European countries, is ..
  101. ncbi Current developments in canine genetics
    Yvonne Marschall
    Institute for Animal Breeding and Genetics, University of Veterinary Medicine Hannover
    Berl Munch Tierarztl Wochenschr 123:325-38. 2010
    ..QTL for skeletal size variations and for canine hip dysplasia have been already identified and for these complex traits the responsible genes and their possible ..

Research Grants3

  1. Prevention of Hip Dysplasia with Thermal Energy
    MANDI LOPEZ; Fiscal Year: 2005
    ..The University of Wisconsin provides an exceptional environment for interaction with experts in a variety of fields, and it is well known for its exceptional research programs, especially in the medical sciences. ..
  2. Impact Damage, Apoptosis, and Early Osteoarthritis
    Nancy Burton Wurster; Fiscal Year: 2003
    ..The in vivo model, in which canine hip dysplasia is invariably accompanied by OA, gives the unique opportunity to look very early at changes in a ..
  3. Fibrillin 2 and Developmental Genetics of Hip Dysplasia in a Canine Model
    Rory Todhunter; Fiscal Year: 2009
    ..Mb on CFA11 influence hip development by interacting with genes on CFA01 and when mutated contribute to canine hip dysplasia. We propose: (1) To measure expression of fibrillin 2 in the round ligament of the femoral head and in the ..