experimental mammary neoplasms

Summary

Summary: Experimentally induced mammary neoplasms in animals to provide a model for studying human BREAST NEOPLASMS.

Top Publications

  1. pmc Gene expression analysis of immune-mediated arrest of tumorigenesis in a transgenic mouse model of HER-2/neu-positive basal-like mammary carcinoma
    Annalisa Astolfi
    Department of Experimental Pathology, Cancer Research Section, University of Bologna, Viale Filopanti 22, I 40126 Bologna, Italy
    Am J Pathol 166:1205-16. 2005
  2. ncbi A paracrine loop between tumor cells and macrophages is required for tumor cell migration in mammary tumors
    Jeffrey Wyckoff
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Cancer Res 64:7022-9. 2004
  3. pmc Progression to malignancy in the polyoma middle T oncoprotein mouse breast cancer model provides a reliable model for human diseases
    Elaine Y Lin
    Center for Study of Reproductive Biology and Women s Health, Departments of Developmental and Molecular Biology Obstetrics and Gynecology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Am J Pathol 163:2113-26. 2003
  4. pmc Expression of the neu protooncogene in the mammary epithelium of transgenic mice induces metastatic disease
    C T Guy
    Institute for Molecular Biology and Biotechnology, McMaster University, Hamilton, Ontario, Canada
    Proc Natl Acad Sci U S A 89:10578-82. 1992
  5. pmc Identification of conserved gene expression features between murine mammary carcinoma models and human breast tumors
    Jason I Herschkowitz
    Lineberger Comprehensive Cancer Center
    Genome Biol 8:R76. 2007
  6. ncbi Direct visualization of macrophage-assisted tumor cell intravasation in mammary tumors
    Jeffrey B Wyckoff
    Gruss Lipper Center for Biophotonics, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Cancer Res 67:2649-56. 2007
  7. ncbi Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis
    Jing Yang
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Cell 117:927-39. 2004
  8. ncbi Single-step induction of mammary adenocarcinoma in transgenic mice bearing the activated c-neu oncogene
    W J Muller
    Harvard Medical School Department of Genetics, Boston, Massachusetts 02115
    Cell 54:105-15. 1988
  9. ncbi Direct evidence for epithelial-mesenchymal transitions in breast cancer
    ANTHONY J TRIMBOLI
    Department of Molecular Genetics, College of Medicine, The Ohio State University, Columbus, OH 43210, USA
    Cancer Res 68:937-45. 2008
  10. ncbi Identification of selective inhibitors of cancer stem cells by high-throughput screening
    Piyush B Gupta
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Cell 138:645-59. 2009

Detail Information

Publications287 found, 100 shown here

  1. pmc Gene expression analysis of immune-mediated arrest of tumorigenesis in a transgenic mouse model of HER-2/neu-positive basal-like mammary carcinoma
    Annalisa Astolfi
    Department of Experimental Pathology, Cancer Research Section, University of Bologna, Viale Filopanti 22, I 40126 Bologna, Italy
    Am J Pathol 166:1205-16. 2005
    ..This gene expression analysis reveals the immune events associated with prevention of tumor development and shows that HER-2/neu transgenic mice represent a good model of a poor-prognosis group of human breast tumors...
  2. ncbi A paracrine loop between tumor cells and macrophages is required for tumor cell migration in mammary tumors
    Jeffrey Wyckoff
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Cancer Res 64:7022-9. 2004
    ..This work provides the first direct evidence for a synergistic interaction between macrophages and tumor cells during cell migration in vivo and indicates a mechanism for how macrophages may contribute to metastasis...
  3. pmc Progression to malignancy in the polyoma middle T oncoprotein mouse breast cancer model provides a reliable model for human diseases
    Elaine Y Lin
    Center for Study of Reproductive Biology and Women s Health, Departments of Developmental and Molecular Biology Obstetrics and Gynecology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Am J Pathol 163:2113-26. 2003
    ..An increased leukocytic infiltration was also closely associated with the malignant transition. This study demonstrates that the PyMT mouse model is an excellent one to understand the biology of tumor progression in humans...
  4. pmc Expression of the neu protooncogene in the mammary epithelium of transgenic mice induces metastatic disease
    C T Guy
    Institute for Molecular Biology and Biotechnology, McMaster University, Hamilton, Ontario, Canada
    Proc Natl Acad Sci U S A 89:10578-82. 1992
    ..Interestingly, many of the tumor-bearing transgenic mice developed secondary metastatic tumors in the lung. These observations suggest that overexpression of the unactivated neu protein can induce metastatic disease after long latency...
  5. pmc Identification of conserved gene expression features between murine mammary carcinoma models and human breast tumors
    Jason I Herschkowitz
    Lineberger Comprehensive Cancer Center
    Genome Biol 8:R76. 2007
    ..To address this need, we characterized mammary tumor gene expression profiles from 13 different murine models using DNA microarrays and compared the resulting data to those from human breast tumors...
  6. ncbi Direct visualization of macrophage-assisted tumor cell intravasation in mammary tumors
    Jeffrey B Wyckoff
    Gruss Lipper Center for Biophotonics, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Cancer Res 67:2649-56. 2007
    ..These results show that the interaction between macrophages and tumor cells lying in close proximity defines a microenvironment that is directly involved in the intravasation of cancer cells in mammary tumors...
  7. ncbi Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis
    Jing Yang
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Cell 117:927-39. 2004
    ..These results establish a mechanistic link between Twist, EMT, and tumor metastasis...
  8. ncbi Single-step induction of mammary adenocarcinoma in transgenic mice bearing the activated c-neu oncogene
    W J Muller
    Harvard Medical School Department of Genetics, Boston, Massachusetts 02115
    Cell 54:105-15. 1988
    ....
  9. ncbi Direct evidence for epithelial-mesenchymal transitions in breast cancer
    ANTHONY J TRIMBOLI
    Department of Molecular Genetics, College of Medicine, The Ohio State University, Columbus, OH 43210, USA
    Cancer Res 68:937-45. 2008
    ..These data provide the first direct evidence for EMT in breast cancer and suggest that its development is favored by myc-initiated events...
  10. ncbi Identification of selective inhibitors of cancer stem cells by high-throughput screening
    Piyush B Gupta
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Cell 138:645-59. 2009
    ..This study demonstrates the ability to identify agents with specific toxicity for epithelial CSCs...
  11. pmc Interleukin 12-mediated prevention of spontaneous mammary adenocarcinomas in two lines of Her-2/neu transgenic mice
    K Boggio
    Department of Clinical and Biological Sciences, University of Turin, 10043 Orbassano, Italy
    J Exp Med 188:589-96. 1998
    ....
  12. pmc Live tissue intrinsic emission microscopy using multiphoton-excited native fluorescence and second harmonic generation
    Warren R Zipfel
    Department of Applied and Engineering Physics, Cornell University, Ithaca, NY 14853, USA
    Proc Natl Acad Sci U S A 100:7075-80. 2003
    ....
  13. ncbi Transgenic Polyoma middle-T mice model premalignant mammary disease
    J E Maglione
    Department of Medicine, Cancer Center, School of Medicine, University of California-San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Cancer Res 61:8298-305. 2001
    ..These results support the use of PyV-mT transgenic mice as a model for investigating the multistep progression of malignant mammary tumorigenesis and metastasis...
  14. ncbi HER-2/neu is a tumor rejection target in tolerized HER-2/neu transgenic mice
    R T Reilly
    Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Cancer Res 60:3569-76. 2000
    ..These transgenic mice provide a spontaneous tumor model for identifying vaccine approaches potent enough to overcome mechanisms of immune tolerance that are likely to exist in patients with cancer...
  15. ncbi Lipopolysaccharide-induced metastatic growth is associated with increased angiogenesis, vascular permeability and tumor cell invasion
    Judith H Harmey
    Department of Cell Biology, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Int J Cancer 101:415-22. 2002
    ..LPS-induced growth and metastasis of 4T1 experimental lung metastases is associated with increased angiogenesis, vascular permeability and tumor cell invasion/migration with iNOS expression implicated in LPS-induced metastasis...
  16. ncbi Parity-induced mammary epithelial cells facilitate tumorigenesis in MMTV-neu transgenic mice
    MaLinda D Henry
    Eppley Institute for Research in Cancer and Allied Diseases and the Department of Pathology and Microbiology, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, NE 68198 6805, USA
    Oncogene 23:6980-5. 2004
    ....
  17. ncbi Myeloid cell expansion elicited by the progression of spontaneous mammary carcinomas in c-erbB-2 transgenic BALB/c mice suppresses immune reactivity
    Cecilia Melani
    Immunotherapy and Gene Therapy Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori, Via G Venezian 1, 20133 Milan, Italy
    Blood 102:2138-45. 2003
    ....
  18. ncbi Arzoxifene, a new selective estrogen receptor modulator for chemoprevention of experimental breast cancer
    N Suh
    Department of Pharmacology, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    Cancer Res 61:8412-5. 2001
    ..Arzoxifene is devoid of the uterotrophic effects of tamoxifen, suggesting that, in contrast to tamoxifen, it is unlikely that the clinical use of arzoxifene will increase the risk of developing endometrial carcinoma...
  19. ncbi p185(neu) protein is required for tumor and anchorage-independent growth, not for cell proliferation of transgenic mammary carcinoma
    P Nanni
    Institute of Cancer Research, University of Bologna, Bologna, Italy
    Int J Cancer 87:186-94. 2000
    ....
  20. ncbi Single cell behavior in metastatic primary mammary tumors correlated with gene expression patterns revealed by molecular profiling
    Weigang Wang
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Cancer Res 62:6278-88. 2002
    ..We conclude that aligning cell behavior in vivo with patterns of gene expression can lead to new insights into the microenvironment of carcinoma cells in the primary tumor and the molecular mechanisms behind cell behavior...
  21. ncbi Role of the tumor suppressor gene Brca1 in genetic stability and mammary gland tumor formation
    C X Deng
    Genetics of Development and Disease Branch, 10 9N105, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, MD 20892, USA
    Oncogene 19:1059-64. 2000
    ....
  22. ncbi Effect of conditional knockout of the type II TGF-beta receptor gene in mammary epithelia on mammary gland development and polyomavirus middle T antigen induced tumor formation and metastasis
    Elizabeth Forrester
    Department of Cancer Biology, Ingram Cancer Center, Nashville, Tennessee, USA
    Cancer Res 65:2296-302. 2005
    ....
  23. pmc Mammary epithelial-specific ablation of the focal adhesion kinase suppresses mammary tumorigenesis by affecting mammary cancer stem/progenitor cells
    Ming Luo
    Department of Internal Medicine, Division of Molecular Medicine and Genetics, Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, Michigan, USA
    Cancer Res 69:466-74. 2009
    ..Together, these results show a novel function of FAK in maintaining the mammary cancer stem/progenitor cell population and provide a novel mechanism by which FAK may promote breast cancer development and progression...
  24. pmc Immune-induced epithelial to mesenchymal transition in vivo generates breast cancer stem cells
    Marta Santisteban
    Department of Oncology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Cancer Res 69:2887-95. 2009
    ..These findings have several important implications related to disease progression and relapse...
  25. ncbi Estrogenic and antiestrogenic properties of resveratrol in mammary tumor models
    K P Bhat
    Program for Collaborative Research in the Pharmaceutical Sciences, Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    Cancer Res 61:7456-63. 2001
    ..In rodent models, carcinogen-induced preneoplastic lesions and mammary tumors are inhibited. These data suggest that resveratrol may have beneficial effects if used as a chemopreventive agent for breast cancer...
  26. ncbi Blocking tumor growth, invasion, and metastasis by maspin in a syngeneic breast cancer model
    H Y Shi
    Baylor College of Medicine, Department of Molecular and Cellular Biology, Houston, Texas 77030, USA
    Cancer Res 61:6945-51. 2001
    ..Thus, maspin can block primary tumor growth as well as invasion and metastasis. These data support the concept that maspin has a strong protective role against tumor progression...
  27. pmc Evidence that transgenes encoding components of the Wnt signaling pathway preferentially induce mammary cancers from progenitor cells
    Yi Li
    Department of Pathology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 100:15853-8. 2003
    ..Thus, the developmental heterogeneity of different breast cancers is in part a consequence of differential effects of oncogenes on distinct cell types in the breast...
  28. pmc Opposing effects of retinoic acid on cell growth result from alternate activation of two different nuclear receptors
    Thaddeus T Schug
    Division of Nutritional Sciences, Cornell University, Ithaca, NY 14850, USA
    Cell 129:723-33. 2007
    ..Opposing effects of RA on cell growth thus emanate from alternate activation of two different nuclear receptors...
  29. ncbi HER2/neu-induced mammary tumorigenesis and angiogenesis are reduced in cyclooxygenase-2 knockout mice
    Louise R Howe
    Department of Cell and Developmental Biology, Weill Medical College of Cornell University, NY, USA
    Cancer Res 65:10113-9. 2005
    ..This finding may help to explain the reduced risk of breast cancer associated with regular use of nonsteroidal anti-inflammatory drugs...
  30. pmc The role of endotoxin/lipopolysaccharide in surgically induced tumour growth in a murine model of metastatic disease
    G P Pidgeon
    Royal College of Surgeons in Ireland, Department of Surgery, Beaumont Hospital, Dublin, Ireland
    Br J Cancer 81:1311-7. 1999
    ..These data indicate that endotoxin introduced during surgery is associated with the enhanced growth of metastases following surgical trauma, by altering the critical balances governing cellular growth and angiogenesis...
  31. ncbi Targeted expression of MDM2 uncouples S phase from mitosis and inhibits mammary gland development independent of p53
    K Lundgren
    Cell Cycle Project, Glaxo Wellcome Research and Development, Research Triangle Park, North Carolina 27709, USA
    Genes Dev 11:714-25. 1997
    ..Additionally, multiple lines of BLGMDM2 transgenic mice developed mammary tumors, confirming that overproduction of MDM2 contributes to tumorigenesis in epithelial cells in vivo...
  32. ncbi Identification and testing of a gene expression signature of invasive carcinoma cells within primary mammary tumors
    Weigang Wang
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Cancer Res 64:8585-94. 2004
    ..ZBP1 reexpression also inhibited metastasis from tumors. These experiments support the involvement in metastasis of the pathways identified in invasive cells, which are regulated by ZBP1...
  33. pmc Effect of ablation or inhibition of stromal matrix metalloproteinase-9 on lung metastasis in a breast cancer model is dependent on genetic background
    Michelle D Martin
    Department of Cancer Biology, Vanderbilt University Medical Center, Nashville, Tennessee 37232 6840, USA
    Cancer Res 68:6251-9. 2008
    ..These strain-specific responses were also observed in a study using a highly selective pharmacologic inhibitor of MMP9 and thus suggest that responses to MMP inhibition are controlled by genetic differences...
  34. ncbi Antitumor activity of rapamycin in a transgenic mouse model of ErbB2-dependent human breast cancer
    Mei Liu
    Program in Signal Transduction Research, The Burnham Institute, La Jolla, California 92037, USA
    Cancer Res 65:5325-36. 2005
    ....
  35. pmc Inducible dimerization of FGFR1: development of a mouse model to analyze progressive transformation of the mammary gland
    Bryan E Welm
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    J Cell Biol 157:703-14. 2002
    ..These data indicate that acute iFGFR1 signaling results in increased lateral budding of the mammary ductal epithelium, and that sustained activation induces alveolar hyperplasia and invasive lesions...
  36. ncbi Invasive potential induced under long-term oxidative stress in mammary epithelial cells
    Kazunori Mori
    Department of Microbiology, Showa University School of Pharmaceutical Sciences, Tokyo, Japan
    Cancer Res 64:7464-72. 2004
    ....
  37. pmc Constitutive telomerase expression promotes mammary carcinomas in aging mice
    Steven E Artandi
    Department of Adult Oncology, Dana Farber Cancer Institute, Harvard Medical School, 44 Binney Street M413, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 99:8191-6. 2002
    ..These data indicate that enforced mTERT expression can promote the development of spontaneous cancers even in the setting of ample telomere reserve...
  38. ncbi A new nude mouse model for postmenopausal breast cancer using MCF-7 cells transfected with the human aromatase gene
    W Yue
    Department of Pharmacology and Experimental Therapeutics, University of Maryland School of Medicine, Baltimore 21201
    Cancer Res 54:5092-5. 1994
    ..Thus, it simulates the situation in the postmenopausal breast cancer patient and could be used to evaluate the effect of aromatase inhibitors and antiestrogens...
  39. pmc Role of cytokines in photodynamic therapy-induced local and systemic inflammation
    S O Gollnick
    PDT Center, Roswell Park Cancer Institute, Elm and Carlton St, Buffalo, NY 14263, USA
    Br J Cancer 88:1772-9. 2003
    ..They also lay the mechanistic groundwork for further ongoing studies that attempt to optimise PDT through the modulation of the critical inflammatory mediators...
  40. ncbi Tumor development by transgenic expression of a constitutively active insulin-like growth factor I receptor
    Joan M Carboni
    Oncology Drug Discovery and Discovery Toxicology, Bristol Myers Squibb Research Institute, Princeton, New Jersey 08534, USA
    Cancer Res 65:3781-7. 2005
    ..This new model should provide new opportunities for further understanding how aberrant IGF-IR signaling leads to tumorigenesis and for optimizing novel antagonists of the receptor kinase...
  41. pmc p53 is a potential mediator of pregnancy and hormone-induced resistance to mammary carcinogenesis
    L Sivaraman
    Department of Molecular and Cellular Biology, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 98:12379-84. 2001
    ..The proliferative block and induction of p53 are operative in both rats and mice, results that support the generality of the proposed hypothesis...
  42. ncbi Lack of sustained regression of c-MYC-induced mammary adenocarcinomas following brief or prolonged MYC inactivation
    Robert B Boxer
    Department of Cancer Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Cancer Cell 6:577-86. 2004
    ..Thus, MYC-induced mammary tumor cells subjected to either brief or prolonged MYC inactivation remain exquisitely sensitive to its oncogenic effects and characteristically progress to a state in which growth is MYC-independent...
  43. ncbi Suppression of 7,12-dimethylbenz(a)anthracene-induced mammary carcinogenesis in rats by resveratrol: role of nuclear factor-kappaB, cyclooxygenase 2, and matrix metalloprotease 9
    Sanjeev Banerjee
    Cytokine Research Laboratory, Department of Bioimmunotherapy, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 62:4945-54. 2002
    ..Overall, our results suggest that resveratrol suppresses DMBA-induced mammary carcinogenesis, which correlates with down-regulation of NF-kappaB, cyclooxygenase-2, and matrix metalloprotease-9 expression...
  44. pmc Mesenchyme Forkhead 1 (FOXC2) plays a key role in metastasis and is associated with aggressive basal-like breast cancers
    Sendurai A Mani
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA
    Proc Natl Acad Sci U S A 104:10069-74. 2007
    ..These observations indicate that FOXC2 plays a central role in promoting invasion and metastasis and that it may prove to be a highly specific molecular marker for human basal-like breast cancers...
  45. ncbi Tumor-derived platelet-derived growth factor-BB plays a critical role in osteosclerotic bone metastasis in an animal model of human breast cancer
    Bing Yi
    Division of Endocrinology and Metabolism, Department of Medicine, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    Cancer Res 62:917-23. 2002
    ..Our data suggest that MCF-7/Neu-derived hPDGF-BB plays a causative role in the development of osteosclerotic bone metastases in this model...
  46. ncbi Centrosome abnormalities, recurring deletions of chromosome 4, and genomic amplification of HER2/neu define mouse mammary gland adenocarcinomas induced by mutant HER2/neu
    Cristina Montagna
    Genetics Branch, Center for Cancer Research, National Cancer Institute NIH, Bldg 9, Rm 1N105, 9 Memorial Drive, Bethesda, MD 20892, USA
    Oncogene 21:890-8. 2002
    ..It is likely that this region contains putative tumor suppressor genes whose inactivation is required for tumor formation in this model of human breast cancer...
  47. ncbi Expression of the int-1 gene in transgenic mice is associated with mammary gland hyperplasia and adenocarcinomas in male and female mice
    A S Tsukamoto
    Department of Microbiology and Immunology, University of California, San Francisco 94143
    Cell 55:619-25. 1988
    ..Mammary and (less frequently) salivary adenocarcinomas occur in these animals at rates indicating that transcriptional activation of int-1 and associated hyperplasia are initiating events in multistep carcinogenesis...
  48. pmc Direct action of estrogen on sequence of progression of human preneoplastic breast disease
    M P Shekhar
    Breast Cancer Program, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Am J Pathol 152:1129-32. 1998
    ....
  49. pmc Heregulin induces transcriptional activation of the progesterone receptor by a mechanism that requires functional ErbB-2 and mitogen-activated protein kinase activation in breast cancer cells
    Leticia Labriola
    Instituto de Biologia y Medicina Experimental, Universidad de Buenos Aires, Buenos Aires 1428, Argentina
    Mol Cell Biol 23:1095-111. 2003
    ..Finally, we demonstrate here for the first time that HRG-activated MAPK can phosphorylate both human and mouse PR in vitro...
  50. ncbi Reducing mammary cancer risk through premature stem cell senescence
    C A Boulanger
    Laboratory of Tumor Immunology and Biology, National Cancer Institute, Bethesda, Maryland, MD 20892, USA
    Oncogene 20:2264-72. 2001
    ..The results suggest a positive correlation between the procreative life-span of mammary epithelial stem cells and mammary cancer risk...
  51. ncbi Transforming growth factor-beta regulates mammary carcinoma cell survival and interaction with the adjacent microenvironment
    Brian Bierie
    Department of Cancer Biology, Vanderbilt University, Nashville, TN 37232 6838, USA
    Cancer Res 68:1809-19. 2008
    ....
  52. ncbi Tamoxifen chemoprevention of a hormone-independent tumor in the proto-neu transgenic mice model
    S Menard
    Department of Experimental Oncology, Istituto Nazionale Tumori, Milan, Italy
    Cancer Res 60:273-5. 2000
    ..In conclusion, TAM can prevent the occurrence of hormone-independent breast carcinoma if given early enough to inhibit normal cells...
  53. ncbi Short-term exposure to estrogen and progesterone induces partial protection against N-nitroso-N-methylurea-induced mammary tumorigenesis in Wistar--Furth rats
    D Medina
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Cancer Lett 169:1-6. 2001
    ..The significance of these results are discussed in terms of the contradictory results in the literature and the role of morphological differentiation in conferring the protective effect...
  54. ncbi Identification and characterization of the immunodominant rat HER-2/neu MHC class I epitope presented by spontaneous mammary tumors from HER-2/neu-transgenic mice
    Anne M Ercolini
    Department of Oncology, Sidney Kimmel Cancer Center at Johns Hopkins, Graduate Program in Immunology, The Johns Hopkins School of Medicine, Baltimore, MD 21231, USA
    J Immunol 170:4273-80. 2003
    ..Discovery of this epitope allows for better characterization of the CD8(+) T cell responses in the neu-N mouse model in which neu-specific tolerance must be overcome to produce effective antitumor immunity...
  55. ncbi Cell proliferation, apoptosis, and expression of cyclin D1 and cyclin E as potential biomarkers in tamoxifen-treated mammary tumors
    Konstantin Christov
    Department of Surgical Oncology, University of Illinois, Chicago, IL, USA
    Breast Cancer Res Treat 77:253-64. 2003
    ....
  56. pmc Vascular endothelial growth factor (VEGF) upregulates BCL-2 and inhibits apoptosis in human and murine mammary adenocarcinoma cells
    G P Pidgeon
    Department of Surgery, Royal College of Surgeons in Ireland, Beaumont Hospital, Beaumont, Dublin 9, Ireland
    Br J Cancer 85:273-8. 2001
    ..Therefore, in addition to its role in angiogenesis and vessel permeability, VEGF acts as a survival factor for tumour cells, inducing Bcl-2 expression and inhibiting tumour cell apoptosis...
  57. ncbi Genetically obese MMTV-TGF-alpha/Lep(ob)Lep(ob) female mice do not develop mammary tumors
    Margot P Cleary
    The Hormel Institute, University of Minnesota, Austin, MN 55912, USA
    Breast Cancer Res Treat 77:205-15. 2003
    ..However, the finding that increased body weight is associated with increased oncogene-induced MT development within the normal weight range provides experimental support for the role of body weight in breast cancer...
  58. pmc Combined allogeneic tumor cell vaccination and systemic interleukin 12 prevents mammary carcinogenesis in HER-2/neu transgenic mice
    P Nanni
    Cancer Research Section, Department of Experimental Pathology, University of Bologna, Italy
    J Exp Med 194:1195-205. 2001
    ..In conclusion, our data show that an allogeneic HER-2/neu-expressing cell vaccine combined with IL-12 systemic treatment can prevent the onset of genetically determined tumors...
  59. ncbi The transcriptional repressor Snail promotes mammary tumor recurrence
    Susan E Moody
    Department of Cancer Biology, Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA
    Cancer Cell 8:197-209. 2005
    ..In aggregate, our observations strongly implicate Snail in the process of breast cancer recurrence...
  60. ncbi Reduced metastasis of Polyoma virus middle T antigen-induced mammary cancer in plasminogen-deficient mice
    T H Bugge
    Division of Developmental Biology, Children s Hospital Research Foundation, Cincinnati, Ohio 45229, USA
    Oncogene 16:3097-104. 1998
    ..The data provide direct evidence that plasmin(ogen) is a tumor progression factor in PymT-induced mammary cancer, and support the hypothesis that hemostatic factors play an important role in tumor biology...
  61. ncbi Altered expression of interleukin 6 and interleukin 10 as a result of photodynamic therapy in vivo
    S O Gollnick
    Department of Molecular Medicine, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Cancer Res 57:3904-9. 1997
    ..We propose that the enhanced IL-10 expression plays a role in the observed suppression of cell-mediated responses seen following PDT...
  62. pmc Elevated expression of activated forms of Neu/ErbB-2 and ErbB-3 are involved in the induction of mammary tumors in transgenic mice: implications for human breast cancer
    P M Siegel
    Institute for Molecular Biology and Biotechnology, McMaster University, Hamilton, Ontario, Canada L8S 4K1
    EMBO J 18:2149-64. 1999
    ....
  63. ncbi Mediators of peripheral blood neutrophilia induced by photodynamic therapy of solid tumors
    Ivana Cecic
    Cancer Imaging Department, BC Cancer Research Centre, 601 West 10th Avenue, BC V5Z 1L3, Vancouver, Canada
    Cancer Lett 183:43-51. 2002
    ..The latter include cytokines IL-1beta, TNF-alpha, IL-6, IL-10, G-CSF and KC, thromboxane, prostaglandins, leukotrienes, histamine, and coagulation factors...
  64. pmc Stromal regulation of neoplastic development: age-dependent normalization of neoplastic mammary cells by mammary stroma
    Maricel V Maffini
    Department of Anatomy and Cellular Biology, Tufts University School of Medicine, 136 Harrison Ave, Boston, MA 02111, USA
    Am J Pathol 167:1405-10. 2005
    ....
  65. ncbi The pea3 subfamily ets genes are required for HER2/Neu-mediated mammary oncogenesis
    T G Shepherd
    Institute for Molecular Biology and Biotechnology, McMaster University, 1280 Main Street, Hamilton, Ontario L8S 4K1, Canada
    Curr Biol 11:1739-48. 2001
    ..PEA3 is also overexpressed in various transgenic mouse models of this disease. Whether PEA3 plays an essential role in HER2/Neu-mediated oncogenesis has heretofore not been addressed...
  66. ncbi Mice expressing a mammary gland-specific R270H mutation in the p53 tumor suppressor gene mimic human breast cancer development
    Susan W P Wijnhoven
    Laboratory of Toxicology, Pathology and Genetics, National Institute of Public Health and the Environment, Bilthoven, The Netherlands
    Cancer Res 65:8166-73. 2005
    ..As such, p53(R270H/+)WAPCre mice provide a well-suited model system to study the role of p53 in breast tumorigenesis and the responsiveness of mammary gland tumors to chemotherapeutics...
  67. ncbi Misregulation of stromelysin-1 expression in mouse mammary tumor cells accompanies acquisition of stromelysin-1-dependent invasive properties
    A Lochter
    Life Sciences Division, Lawrence Berkeley National Laboratory, University of California, Berkeley, California 94720, USA
    J Biol Chem 272:5007-15. 1997
    ..Thus misregulation of stromelysin-1 expression appears to be an important aspect of mammary tumor cell progression to an invasive phenotype...
  68. ncbi Immunoprevention of HER-2/neu transgenic mammary carcinoma through an interleukin 12-engineered allogeneic cell vaccine
    Carla De Giovanni
    Department of Experimental Pathology, University of Bologna, Bologna
    Cancer Res 64:4001-9. 2004
    ..However, IL-12-engineered cell vaccine induced much lower circulating IL-12 and IFN-gamma, and therefore lower potential side effects and systemic toxicity...
  69. ncbi Oncogenic signaling pathways activated in DMBA-induced mouse mammary tumors
    Nicolas Currier
    Boston University School of Medicine, Department of Medicine, Boston, MA, USA
    Toxicol Pathol 33:726-37. 2005
    ..These data suggest that environmental carcinogens can produce long-lasting alterations in growth and anti-apoptotic pathways, leading to mammary tumorigenesis...
  70. ncbi Inhibition of in vivo breast cancer growth by antisense oligodeoxynucleotides to type I insulin-like growth factor receptor mRNA involves inactivation of ErbBs, PI-3K/Akt and p42/p44 MAPK signaling pathways but not modulation of progesterone receptor acti
    Mariana Salatino
    Laboratory of Molecular Mechanisms of Carcinogenesis, Instituto de Biología y Medicina Experimental IBYME, CONICET, Obligado 2490, Buenos Aires 1428, Argentina
    Oncogene 23:5161-74. 2004
    ..Our results for the first time demonstrated that breast cancer growth can be inhibited by direct in vivo administration of IGF-IR AS[S]ODNs...
  71. pmc A mouse mammary epithelial cell model to identify molecular mechanisms regulating breast cancer progression
    Vassiliki Karantza-Wadsworth
    Division of Medical Oncology, Department of Medicine, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, New Jersey, USA
    Methods Enzymol 446:61-76. 2008
    ....
  72. pmc Transgenes expressing the Wnt-1 and int-2 proto-oncogenes cooperate during mammary carcinogenesis in doubly transgenic mice
    H Kwan
    Department of Microbiology and Immunology, University of California, San Francisco 94143
    Mol Cell Biol 12:147-54. 1992
    ....
  73. ncbi Modeling human breast cancer metastasis in mice: maspin as a paradigm
    H Y Shi
    Baylor College of Medicine, Department of Molecular and Cellular Biology, Houston, Texas 77030, USA
    Histol Histopathol 18:201-6. 2003
    ..Elucidating the molecular mechanism of maspin action will shed light on our understanding of breast cancer invasion and metastasis...
  74. ncbi Destruction of nonimmunogenic mammary tumor cells by a fusogenic oncolytic herpes simplex virus induces potent antitumor immunity
    Mikihito Nakamori
    Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX 77030, USA
    Mol Ther 9:658-65. 2004
    ..We conclude that the fusogenic capacity of Synco-2D enables it to elicit antitumor immunity exceeding that induced by more conventional oncolytic viruses...
  75. ncbi Transcriptional cooperation between the transforming growth factor-beta and Wnt pathways in mammary and intestinal tumorigenesis
    Etienne Labbé
    Departments of Medical Biophysics and Biochemistry, University of Toronto, 160 College Street, Toronto, Ontario, Canada
    Cancer Res 67:75-84. 2007
    ..Our results indicate that the TGF-beta and Wnt/beta-catenin pathways are firmly intertwined and generate a unique gene expression pattern that can contribute to tumor progression...
  76. ncbi Rapamycin inhibits growth of premalignant and malignant mammary lesions in a mouse model of ductal carcinoma in situ
    Ruria Namba
    Department of Pathology and Laboratory Medicine, School of Medicine, University of California, Davis, Sacramento, CA 95817, USA
    Clin Cancer Res 12:2613-21. 2006
    ..Both of these models were derived from mammary lesions in Tg(MMTV-PyV-mT) mice...
  77. ncbi Activated neu induces rapid tumor progression
    C T Guy
    Institute for Molecular Biology and Biotechnology, McMaster University, Hamilton, Ontario, Canada
    J Biol Chem 271:7673-8. 1996
    ..These results indicate that tissue context is an important parameter in malignant progression and that expression of appropriate levels of activated neu is sufficient for rapid production of mammary tumors in transgenic mice...
  78. ncbi Estradiol promotes growth and angiogenesis in polyoma middle T transgenic mouse mammary tumor explants
    Charlotta Dabrosin
    Department of Pathology and Molecular Medicine, Centre for Gene Therapeutics, McMaster University, Hamilton, Ontario, Canada
    Breast Cancer Res Treat 78:1-6. 2003
    ..This immune-competent animal model offers the opportunity to study molecular events in estrogen dependent breast cancer...
  79. ncbi Twist is up-regulated in response to Wnt1 and inhibits mouse mammary cell differentiation
    Louise R Howe
    Department of Cell and Developmental Biology, Weill Medical College of Cornell University, New York, New York 10021, USA
    Cancer Res 63:1906-13. 2003
    ....
  80. ncbi Reduced metastasis of transgenic mammary cancer in urokinase-deficient mice
    Kasper Almholt
    Finsen Laboratory, Rigshospitalet 8621, Strand boulevarden 49, DK 2100 Copenhagen, Denmark
    Int J Cancer 113:525-32. 2005
    ..We show that metastasis is strongly and selectively decreased in uPA-deficient mice, suggesting that uPA-directed antimetastatic therapy would be efficacious and have limited side effects...
  81. pmc Tumor escape in a Wnt1-dependent mouse breast cancer model is enabled by p19Arf/p53 pathway lesions but not p16 Ink4a loss
    Michael T Debies
    Jake Gittlen Cancer Research Foundation, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    J Clin Invest 118:51-63. 2008
    ..Thus, p19 Arf/p53 pathway lesions may promote mammary cancer relapse even when inhibition of a targeted oncogenic signaling pathway remains in force...
  82. ncbi The tumor suppressor gene Brca1 is required for embryonic cellular proliferation in the mouse
    R Hakem
    Amgen Institute, Toronto, Ontario, Canada
    Cell 85:1009-23. 1996
    ..Thus, the death of Brca1(5-6) mutant embryos prior to gastrulation may be due to a failure of the proliferative burst required for the development of the different germ layers...
  83. ncbi Src phosphorylates Tyr284 in TGF-beta type II receptor and regulates TGF-beta stimulation of p38 MAPK during breast cancer cell proliferation and invasion
    Amy J Galliher
    Department of Pharmacology, University of Colorado Health Sciences Center, 12801 East 17th Avenue, Aurora, CO 80045, USA
    Cancer Res 67:3752-8. 2007
    ....
  84. ncbi Contribution of myeloid and lymphoid host cells to the curative outcome of mouse sarcoma treatment by photodynamic therapy
    M Korbelik
    Cancer Imaging Department, British Columbia Cancer Agency, Vancouver, Canada
    Cancer Lett 137:91-8. 1999
    ..These results provide direct evidence that the contribution of neutrophils, macrophages and T lymphocytes is essential for the maintenance of long-term control of PDT-treated tumors...
  85. ncbi Identification of tumorsphere- and tumor-initiating cells in HER2/Neu-induced mammary tumors
    Jeff C Liu
    Division of Cell and Molecular Biology, Toronto General Research Institute University Health Network, Toronto, Ontario, Canada
    Cancer Res 67:8671-81. 2007
    ..In addition, the similarity between TICs and TFUs in this system provides a rationale for TFU-based screens to target tumor-initiating cells in HER2(+) breast cancer...
  86. ncbi Overexpression of cyclooxygenase-2 is sufficient to induce tumorigenesis in transgenic mice
    C H Liu
    Center for Vascular Biology, Department of Physiology, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    J Biol Chem 276:18563-9. 2001
    ..These data indicate that enhanced Cox-2 expression is sufficient to induce mammary gland tumorigenesis. Therefore, inhibition of Cox-2 may represent a mechanism-based chemopreventive approach for carcinogenesis...
  87. pmc Selective estrogen receptor modulators inhibit growth and progression of premalignant lesions in a mouse model of ductal carcinoma in situ
    Ruria Namba
    Department of Pathology and Laboratory Medicine, School of Medicine, University of California, Davis, Sacramento, CA, USA
    Breast Cancer Res 7:R881-9. 2005
    ..We studied the ovarian-hormone-responsiveness of one of the lines with a particular focus on the effects of two related SERMs, tamoxifen and ospemifene...
  88. ncbi Insights from transgenic mouse models of ERBB2-induced breast cancer
    Josie Ursini-Siegel
    Departments of Medicine and Biochemistry, McGill University, Montreal, Quebec, Canada
    Nat Rev Cancer 7:389-97. 2007
    ..In addition, a mouse model has recently been described that accurately recapitulates many of the hallmarks associated with the early stages of the human disease...
  89. ncbi Mammary development and tumorigenesis in mice expressing a truncated human Notch4/Int3 intracellular domain (h-Int3sh)
    Ahmed Raafat
    Mammary Biology and Tumorigenesis Laboratory, National Cancer Institute, NIH, Bethesda, MD 2089, USA
    Oncogene 23:9401-7. 2004
    ..We speculate that the Notch4/Int3 ICD-induced block to mammary gland development and tumorigenesis are consequences of an increasing gradient of CBF1-dependent Notch4/Int3 signaling...
  90. ncbi Tumor-associated macrophages press the angiogenic switch in breast cancer
    Elaine Y Lin
    Department of Developmental and Molecular Biology, Center of Reproductive Biology and Women s Health, Albert Einstein Cancer Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Cancer Res 67:5064-6. 2007
    ..These findings establish a causal linkage to explain well-documented clinical correlations between macrophages, microvessel density, and poor prognosis in breast tumors...
  91. ncbi Osteopontin expression in mammary gland development and tumorigenesis
    S R Rittling
    Department of Cell, Developmental, and Neurobiology, Rutgers University, Piscataway, New Jersey 08855, USA
    Cell Growth Differ 8:1061-9. 1997
    ....
  92. ncbi Induction of systemic neutrophil response in mice by photodynamic therapy of solid tumors
    I Cecic
    Cancer Imaging Department, British Columbia Cancer Research Centre, 601 West 10th Avenue, Vancouver, British Columbia, Canada V5Z 1L3
    Photochem Photobiol 74:712-20. 2001
    ..This reaction reflects rapid and massive mobilization and activation of neutrophils for the destruction of PDT-treated tumor tissue...
  93. ncbi Genetic background affects susceptibility to mammary hyperplasias and carcinomas in Apc(min)/+ mice
    A R Moser
    Department of Human Oncology, University of Wisconsin Madison, 600 Highland Avenue, Madison, WI 53792, USA
    Cancer Res 61:3480-5. 2001
    ..Susceptibility to intestinal tumors was independent of mammary tumor susceptibility in most hybrids. These results indicate that genetic background can affect independently the phenotypes conferred by the Min allele of APC:..
  94. ncbi Development of mammary adenocarcinomas by tissue-specific knockout of Brca2 in mice
    T Ludwig
    Department of Anatomy and Cell Biology, Columbia University, New York, NY 10032, USA
    Oncogene 20:3937-48. 2001
    ..The implications of these observations in the context of models positing that Brca2 is involved in the maintenance of genomic stability are discussed...
  95. pmc Activation of Akt (protein kinase B) in mammary epithelium provides a critical cell survival signal required for tumor progression
    J Hutchinson
    MOBIX, McMaster University, Hamilton, Ontario, Canada
    Mol Cell Biol 21:2203-12. 2001
    ..Taken together these observations indicate that activation of Akt can contribute to tumor progression by providing an important cell survival signal but does not promote metastatic progression...
  96. ncbi Regulatory T cells prevent CD8 T cell maturation by inhibiting CD4 Th cells at tumor sites
    Nathalie Chaput
    Laboratoire de Biologie et Thérapeutique des Pathologies Immunitaires, Centre National de la Recherche Scientifique Unité Mixte de Recherche 7087, Universite Pierre et Marie Curie Paris 6, Hopital Pitie Salpetriere, Paris, France
    J Immunol 179:4969-78. 2007
    ..The Tregs in our model prevent Th cell activation and subsequent development of efficient CD8 T cell activity required for the control of tumor growth...
  97. ncbi Cellular responses of mammary carcinomas to aromatase inhibitors: effects of vorozole
    K Christov
    Department of Surgical Oncology, University of Illinois, Chicago 60612, USA
    Breast Cancer Res Treat 60:117-28. 2000
    ....
  98. pmc Six1 expands the mouse mammary epithelial stem/progenitor cell pool and induces mammary tumors that undergo epithelial-mesenchymal transition
    Erica L McCoy
    Program in Molecular Biology, University of Colorado School of Medicine, Aurora, Colorado 80045, USA
    J Clin Invest 119:2663-77. 2009
    ..Our data thus provide genetic evidence for a potent oncogenic role for Six1 in mammary epithelial neoplasia, including promotion of EMT and stem cell-like features...
  99. ncbi Vitamin D receptor (VDR) ablation alters carcinogen-induced tumorigenesis in mammary gland, epidermis and lymphoid tissues
    Glendon M Zinser
    Department of Biological Sciences, University of Notre Dame, 214 Galvin Life Sciences Building, Notre Dame, IN 46556, USA
    J Steroid Biochem Mol Biol 97:153-64. 2005
    ..These data indicate that VDR ablation alters susceptibility to DMBA-induced carcinogenesis in a tissue specific fashion, and provide support that optimal VDR signaling may act to suppress tumorigenesis...
  100. ncbi Knockdown of STAT3 expression by RNA interference inhibits the induction of breast tumors in immunocompetent mice
    Xiaoyang Ling
    Department of Molecular Pathology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 65:2532-6. 2005
    ..These studies suggest that stable expression of small interfering RNA for STAT3 has potential as a therapeutic strategy for breast cancer...
  101. ncbi Mouse mammary tumor biology: a short history
    Robert D Cardiff
    Center for Comparative Medicine, Department of Pathology and Laboratory Medicine, School of Medicine, University of California, Davis, California 95616, USA
    Adv Cancer Res 98:53-116. 2007
    ..If Einstein was correct in that "we stand on the shoulders of giants," the neophytes should meet their giants...

Research Grants71

  1. MAMMARY CANCER PREVENTION BY CONJUGATED LINOLEIC ACID
    Clement Ip; Fiscal Year: 2007
    ..abstract_text> ..
  2. Molecular biomarkers of selenium chemoprevention
    Clement Ip; Fiscal Year: 2006
    ..The goal is to broaden our understanding of the significance of clonal suppression of early transformed cells in selenium protection of cancer. ..
  3. BIOLOGY OF NEOPLASTIC TRANSFORMATION IN BREAST CANCER
    Robert Cardiff; Fiscal Year: 2005
    ..The goal of this project is to develop a well-characterized model for breast cancer development and to dissect the molecular pathways involved in tumor formation. ..
  4. CANCER PREVENTION BY SELENIUM-ENRICHED ALLIUM VEGETABLES
    Clement Ip; Fiscal Year: 2003
    ..The objective is to corroborate the significance of clonal suppression of preneoplastic lesions in selenium protection of cancer. ..
  5. Selenium molecular signaling in human prostate cancer
    Clement Ip; Fiscal Year: 2007
    ..Aim 4 is to study the transcriptional control of GADD153 by selenium. The proposed research is thus designed to examine systemically the impact of GADD153 induction as a result of selenium treatment. ..
  6. 25TH IABCR CONGRESS CONFERENCE: PERSONALIZED BREAST CANCER THERAPY
    Robert Cardiff; Fiscal Year: 2006
    ..The session will also include a plenary lecture from Dr. A Ullrich who pioneered the concept of targeting the HER2 oncogene in the treatment of breast cancer. [unreadable] [unreadable] [unreadable] [unreadable]..
  7. PRECLINICAL MODELS OF BREAST CANCER
    Robert Cardiff; Fiscal Year: 2003
    ..The theme of the workshop is "High Throughput Phenotyping: From Mouse to Molecule in One Day!" It will allow the student to examine and compare the best and fastest phenotyping technology currently available. ..
  8. MECHANISMS OF THE HORMONAL PREVENTION OF BREAST CANCER
    Daniel Medina; Fiscal Year: 2006
    ..The molecular understanding of the fundamental biological events involved in hormone-induced growth and differentiation will provide a rationale for developing new approaches for preventing human breast cancer. ..
  9. P53 AND MOUSE MAMMARY TUMORIGENESIS
    Daniel Medina; Fiscal Year: 2004
    ..In summary, this model allows one to analyze the biological, genetic and molecular consequences of p53 gene deletion in the in situ mammary gland by taking advantage of transplantation methods. ..
  10. In Utero Mammary Cancer Risk with Resveratrol and TCDD
    CORAL LAMARTINIERE; Fiscal Year: 2008
    ..Programming breast cancer chemoprevention from in utero exposure to a nutritional agent would be a novel breakthrough for women's health. [unreadable] [unreadable] [unreadable]..
  11. ANDROGEN SYNTHESIS INHIBITORS FOR PROSTATE CANCER
    Angela Brodie; Fiscal Year: 2008
    ..Determine effective doses, scheduling, and route of administration and b. Compare the effect of lead inhibitors and castration on apoptosis to identify the best compound. ..
  12. Genistein Impriting Against Prostate Cancer
    CORAL LAMARTINIERE; Fiscal Year: 2003
    ..We propose this in a dietary model at "physiological concentrations." ..
  13. In Utero TCDD Programming for Mammary Cancer
    CORAL LAMARTINIERE; Fiscal Year: 2005
    ..abstract_text> ..
  14. SELENIUM AND LUNG CANCER RISK
    Henry Thompson; Fiscal Year: 2004
    ..In addition, this work has the potential to provide new biomarkers with which to assess lung cancer risk and its modulation. ..
  15. Aspirin for Breast Cancer Prevention
    LOUISE HOWE; Fiscal Year: 2006
    ..abstract_text> ..
  16. TUMOR APOPTOSIS AS MAJOR DETERMINANT OF IMMUNOGENICITY
    Sandra Demaria; Fiscal Year: 2006
    ..These studies will provide the basis for further pre-clinical and clinical studies testing whether levels of apoptosis promoting anti-tumor immunity can be induced by chemotherapy and irradiation. ..
  17. Combination Chemoprevention of ER-Negative Breast Cancer
    LOUISE HOWE; Fiscal Year: 2004
    ..The results of this study will provide the basis for evaluating this combination approach in women at high risk for breast cancer. ..
  18. TUMOR OXYGENATION, VASCULARIZATION, AND RADIORESPONSE
    Bruce Fenton; Fiscal Year: 2009
    ..These results with lead to the more rational and optimal design of effective combined therapies, thereby ultimately accelerating their implementation into clinical protocols. ..
  19. Neoadjuvant Cytokine Immunotherapy by PLA Microspheres
    Michael Sabel; Fiscal Year: 2007
    ..I will pursue this area of investigation as a full-time faculty member, with full commitment from the Department of General Surgery and the Division of Surgical Oncology at the University of Michigan Medical Center. ..
  20. P27Kipl deficiency, potential promoter of carcinogenesis
    Konstantin Christov Tzelkov; Fiscal Year: 2003
    ..abstract_text> ..
  21. Tumor Diagnosis through Enhanced Ultrasound Imaging
    Michael Oelze; Fiscal Year: 2003
    ..6. Several techniques for combining typical ultrasound images with the quantification of tissue microstructures will be evaluated for facilitation of clinical detection and diagnosis of disease. ..
  22. Improving the spatial resolution of ultrasonic imaging using coded excitation
    Michael Oelze; Fiscal Year: 2008
    ..Effects of focusing, phase aberration and attenuation on performance of the REC technique will be quantified. [unreadable] [unreadable] [unreadable]..
  23. Omega-3 fat to reduce risk for breast cancer
    WANDA ELAINE HARDMAN; Fiscal Year: 2010
    ....
  24. HLA classl complex expression in breast cancer immunity
    Keith Knutson; Fiscal Year: 2009
    ..The results will likely lead to the identification of specific molecule associated with antigen presentation that could be either a novel therapeutic target or biomarker of disease outcome. ..
  25. Role of growth hormone in breast cancer
    Steven Swanson; Fiscal Year: 2006
    ..Results from these studies could be rapidly translated to the clinic since a GH antagonist (pegvisomant) is currently in phase III trials for the treatment of acromegaly. ..
  26. Tilting the balance in cancer immunotherapy and autoimmunity
    Wei Zen Wei; Fiscal Year: 2010
    ..Establish a vaccination regimen to inhibit spontaneous tumorigenesis and tumor metastasis, and 3. Amplify the immunogenicity of a growing tumor by in situ transfection with TetC DNA. ..
  27. scVEGF Targeted Radiotherapy of Mammary and Colonic Cancer
    FRANCIS GERARD BLANKENBERG; Fiscal Year: 2010
    ..Successful completion of our proposal will give the needed preclinical data for pursuing scVEGF targeted radiotherapy in other models and ultimately clinical applications. ..
  28. Tumor-induced immune suppression.
    Suzanne Ostrand Rosenberg; Fiscal Year: 2010
    ..abstract_text> ..
  29. IMAGING APOPTOSIS IN VIVO WITH TECHNETIUM 99M ANNEXIN
    Francis Blankenberg; Fiscal Year: 2007
    ..Completion of this proposal will aid in the design and planning of clinical trials that will study the use of serial annexin V imaging as a non-invasive marker of cellular injury and therapeutic efficacy. ..
  30. Ex vivo expansion of HER-2/neu specific T helper cells
    Keith Knutson; Fiscal Year: 2008
    ..abstract_text> ..
  31. Analysis of serum folate receptor and antibody level for ovarian cancer detection
    Keith Knutson; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  32. Pharmacogenetics of Sulfate Conjugation
    VIRGIL JORDAN; Fiscal Year: 2006
    ..These results will increase our understanding of the contribution of SULT1A1 pharmacogenetics to individual variation in response to estrogens and an important antiestrogen. ..
  33. POLYAMINE INVOLVEMENT IN MAMMARY CARCINOGENESIS
    Andrea Manni; Fiscal Year: 2001
    ....
  34. MAMMARY TUMOR CHEMOPREVENTION BY ANGIOGENIC INHIBITORS
    Sue Heffelfinger; Fiscal Year: 2003
    ..In addition, this study presents a non-hormonal approach to the problem of chemoprophylaxis in high-risk women. ..
  35. Tumor cell antigen presentation to CD4 + T lymphocytes
    Suzanne Ostrand Rosenberg; Fiscal Year: 2004
    ..of anti-tumor immunity? Which effector cells, cytokines, and chemokines are induced during therapy? 5) Does tumor burden correlate with tumor-induced immuno-suppression? Does surgical removal of primary tumor reverse mmuno-suppression? ..
  36. Polyamines and Breast Cancer Biology
    Andrea Manni; Fiscal Year: 2005
    ..The ultimate goal of these studies is to identify critical signaling molecules which can be targeted in conjunction with antipolyamine therapy to optimize prevention of metastasis from breast cancer. ..
  37. EFFECT OF RALOXIFENE ON SALIVARY STEROIDS
    VIRGIL JORDAN; Fiscal Year: 2002
    ..Most importantly, completion of the study will validate an important new methodology to monitor the ovarian effects of any new chemopreventive that can be used in premenopausal women. ..
  38. Interactions of Black Cohosh with Cancer Therapy
    Sara Rockwell; Fiscal Year: 2005
    ..This project will assess these possibilities. The findings will show whether this herb is inactive and harmless, potentially dangerous to breast cancer patients, or of potential value in the treatment of this disease. ..
  39. Role of growth hormone in prostate cancer: rodent models
    Steven Swanson; Fiscal Year: 2002
    ..Furthermore, these new genetically defined animal models could be used to address fundamental questions regarding the role of GH/IGF in prostate growth, differentiation and carcinogenesis. ..
  40. IMAGING APOPTOSIS IN VIVO WITH TECHNETIUM 99M ANNEXIN
    Francis Blankenberg; Fiscal Year: 2001
    ..abstract_text> ..
  41. DEVELOPMENTAL CONTROL OF CYTOKERATIN EXPRESSION
    Robert Oshima; Fiscal Year: 2002
    ....
  42. ONCOGENE SPECIFICITY IN ORGAN-DEFINED CANCERS
    Michael Gould; Fiscal Year: 2001
    ....
  43. Radioimmunotherapy of opportunistic infections
    Ekaterina Dadachova; Fiscal Year: 2003
    ..It will also provide some understanding of the fundamentals of interactions between microorganisms and antibodies radiolabeled with particulate-emitting radioisotopes in vitro and in vivo. ..
  44. PDEF and survivin: cancer prognosis, initiation, progression and metastasis
    Fengzhi Li; Fiscal Year: 2010
    ..These studies may provide novel approaches for cancer prognosis and personalized medicine, by considering survivin and PDEF as interconnected biomarkers and targets. ..
  45. Targeted Recombinant VSV Virus to Treat Breast Cancer
    Ira Bergman; Fiscal Year: 2008
    ..The proposal focuses on breast cancer but could be equally applied to many other cancers for which suitable cell surface targets exist. [unreadable] [unreadable]..
  46. Rhenium-188 therapy of NIS-expressing breast tumors
    Ekaterina Dadachova; Fiscal Year: 2003
    ..The long-term goal of this research is to contribute to the development of a novel cost-effective radionuclide therapy for treatment of breast cancer and, possibly, for other NIS-expressing cancers such as thyroid cancer. ..
  47. CHEMOPREVENTION OF MAMMARY TUMORS BY TAMOXIFEN AND SOY
    Andreas Constantinou; Fiscal Year: 2002
    ..2) Identify the mechanism of the anticipated additive/synergistic chemopreventive effect between tamoxifen and the active soy component. ..
  48. Treatment of lung cancer
    Derick Lau; Fiscal Year: 2008
    ..The long-term goal is to develop these peptide ligands as molecularly targeted therapy for lung cancer. 4. To recruit and train hematology and oncology specialists in clinical research of cancer therapy. ..
  49. Targeting GRP78/BIP As An Adjunct Therapy For EGFR-positive Breast Cancer
    Marina Backer; Fiscal Year: 2008
    ..We expect that this data establish feasibility of clinical development for EGF-SLiP. [unreadable] [unreadable] [unreadable]..
  50. High Resolution Gold Labels for EM
    James Hainfeld; Fiscal Year: 2007
    ..The gold labels will additionally be used to better align the complexes to improve reconstructions from conical tilt pairs using cryoEM. ..
  51. Mechanisms of Growth Factor-Estrogen Receptor Crosstalk
    Stephen Safe; Fiscal Year: 2006
    ..abstract_text> ..
  52. Analysis of New Dendritic Cell Costimulatory Molecule
    Drew Pardoll; Fiscal Year: 2006
    ....
  53. Estrogen Receptors and Maintenance of Lens Transparency
    Vicki Davis; Fiscal Year: 2005
    ..This study will provide the gateway for future studies to investigate how exposure to various estrogens influence risk of age-related cataracts and the potential of estrogens as a therapy for cataract prevention. ..
  54. Diffuse optical tomography system for molecular imaging
    Ralph Weissleder; Fiscal Year: 2005
    ....
  55. c-Myc, growth factor and breast cancer
    Dezhong Liao; Fiscal Year: 2007
    ..abstract_text> ..
  56. HIGH EFFICIENCY LYMPHOCYTE LABELING FOR IN VIVO TRACKING
    Ralph Weissleder; Fiscal Year: 2004
    ..Furthermore, the investigators believe that the proposed research is in the widest interest to the current NIAID program and other research programs in further developing robust tools to track immune cells in vivo. ..
  57. Very-High-Frequency Ultrasound Imaging With Coded Signals and Annular Arrays
    Jonathan Mamou; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  58. Quantitative Assessment of Murine Tumors with MicroPET.
    Craig Abbey; Fiscal Year: 2004
    ..The third study proposes a study in which a well-known therapeutic agent, tamoxifen, is introduced. The data from this study will allow evaluation of the magnitude and statistical significance of a therapeutic effect. ..
  59. Electric Field - Forced Gene Transfer In Solid Tumors
    Fan Yuan; Fiscal Year: 2006
    ..abstract_text> ..
  60. Local Delivery of Breast Cancer Chemopreventives Using Mesenchymal Stem Cells
    Teresa Rose Hellekant; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  61. RENAL CANCER ANTIGENS RECOGNIZED BY CD4 T CELLS
    Drew Pardoll; Fiscal Year: 2001
    ....
  62. IMAGING THROMBOEMBOLISM WITH FIBRIN AVID TC-99M-PEPTIDE
    Mathew Thakur; Fiscal Year: 2002
    ..Because there are no agents currently available than can scintigraphically provide "hot spot" images of old (24 hr or older) clots and PE, the commercial potential for this agent is very high. ..
  63. Precancerous Mammary Transcriptome in Mice after Estrog*
    Teresa Rose Hellekant; Fiscal Year: 2006
    ..Knowing more about cancer molecules will bring more preventive agents quickly to clinical trials. ..
  64. Survivin expression and cancer cell drug resistance
    Fengzhi Li; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  65. Physical Activity Measurement in Older Adults
    Lisa Colbert; Fiscal Year: 2007
    ..This methodology can then be incorporated into future studies examining the associations between doses of physical activity and various health outcomes. [unreadable] [unreadable]..
  66. Seasonal Plasticity of Brain and Behavior
    Leah Pyter; Fiscal Year: 2005
    ..3) To determine whether photoperiod also affects non-spatial learning and memory tasks. This research will provide insights into the mechanisms of seasonal plasticity of brain and behavior ..
  67. Modulation of a breast cancer pathway by pregnancy
    Teresa Rose Hellekant; Fiscal Year: 2005
    ..This application has the following specific aims: Aim 1. Develop transgenic mice that permit manipulation of TGFa expression in mammary epithelium. Aim 2. Establish how prior pregnancy affects TGFa -induced mammary tumorigenesis. ..
  68. Stromal TGFbeta in tumor progression
    Nikki Cheng; Fiscal Year: 2006
    ....