experimental arthritis

Summary

Summary: ARTHRITIS that is induced in experimental animals. Immunological methods and infectious agents can be used to develop experimental arthritis models. These methods include injections of stimulators of the immune response, such as an adjuvant (ADJUVANTS, IMMUNOLOGIC) or COLLAGEN.

Top Publications

  1. ncbi Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand
    Y Y Kong
    Amgen Institute, Toronto, Ontario, Canada
    Nature 402:304-9. 1999
  2. ncbi Inhibition of interleukin-33 signaling attenuates the severity of experimental arthritis
    Gaby Palmer
    University Hospital of Geneva, and University of Geneva School of Medicine, Geneva, Switzerland
    Arthritis Rheum 60:738-49. 2009
  3. pmc T cell self-reactivity forms a cytokine milieu for spontaneous development of IL-17+ Th cells that cause autoimmune arthritis
    Keiji Hirota
    Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606 8507, Japan
    J Exp Med 204:41-7. 2007
  4. ncbi Novel suppressive function of transitional 2 B cells in experimental arthritis
    Jamie G Evans
    Centre for Rheumatology Research, Department of Medicine, University College London, 46 Cleveland Street, London, United Kingdom
    J Immunol 178:7868-78. 2007
  5. pmc Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction
    Kojiro Sato
    Department of Cell Signaling, Graduate School, and COE Program for Frontier Research on Molecular Destruction and Reconstruction of Tooth and Bone, Tokyo Medical and Dental University, Tokyo 113 8549, Japan
    J Exp Med 203:2673-82. 2006
  6. pmc Preferential recruitment of CCR6-expressing Th17 cells to inflamed joints via CCL20 in rheumatoid arthritis and its animal model
    Keiji Hirota
    Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606 8507, Japan
    J Exp Med 204:2803-12. 2007
  7. pmc Enhanced autoimmunity, arthritis, and encephalomyelitis in mice with a reduced oxidative burst due to a mutation in the Ncf1 gene
    Malin Hultqvist
    Section for Medical Inflammation Research, Lund University, SE 22184 Lund, Sweden
    Proc Natl Acad Sci U S A 101:12646-51. 2004
  8. pmc Dipeptidyl peptidase I activates neutrophil-derived serine proteases and regulates the development of acute experimental arthritis
    April M Adkison
    Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri, USA
    J Clin Invest 109:363-71. 2002
  9. pmc Mast cell deficiency in Kit(W-sh) mice does not impair antibody-mediated arthritis
    Joseph S Zhou
    Department of Medicine, Harvard Medical School, and Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Exp Med 204:2797-802. 2007
  10. ncbi Utility of animal models for identification of potential therapeutics for rheumatoid arthritis
    M Hegen
    Inflammation Discovery Research, Wyeth Research, Cambridge, MA 02140 2311, USA
    Ann Rheum Dis 67:1505-15. 2008

Detail Information

Publications363 found, 100 shown here

  1. ncbi Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand
    Y Y Kong
    Amgen Institute, Toronto, Ontario, Canada
    Nature 402:304-9. 1999
    ..These results show that both systemic and local T-cell activation can lead to OPGL production and subsequent bone loss, and they provide a novel paradigm for T cells as regulators of bone physiology...
  2. ncbi Inhibition of interleukin-33 signaling attenuates the severity of experimental arthritis
    Gaby Palmer
    University Hospital of Geneva, and University of Geneva School of Medicine, Geneva, Switzerland
    Arthritis Rheum 60:738-49. 2009
    ..The aim of this study was to examine IL-33 production in human and mouse joints and to investigate the role of IL-33 and T1/ST2 in experimental arthritis.
  3. pmc T cell self-reactivity forms a cytokine milieu for spontaneous development of IL-17+ Th cells that cause autoimmune arthritis
    Keiji Hirota
    Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606 8507, Japan
    J Exp Med 204:41-7. 2007
    ..Extrinsic or intrinsic stimuli further expand these cells, thereby triggering autoimmune disease. Intervention in these events at cellular and molecular levels is useful to treat and prevent autoimmune disease, in particular RA...
  4. ncbi Novel suppressive function of transitional 2 B cells in experimental arthritis
    Jamie G Evans
    Centre for Rheumatology Research, Department of Medicine, University College London, 46 Cleveland Street, London, United Kingdom
    J Immunol 178:7868-78. 2007
    ..The ability to regulate an established immune response by T2-MZP B cells endows this subset of B cells with a striking and previously unrecognized immunoregulatory potential...
  5. pmc Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction
    Kojiro Sato
    Department of Cell Signaling, Graduate School, and COE Program for Frontier Research on Molecular Destruction and Reconstruction of Tooth and Bone, Tokyo Medical and Dental University, Tokyo 113 8549, Japan
    J Exp Med 203:2673-82. 2006
    ..Thus, Th17 is a powerful therapeutic target for the bone destruction associated with T cell activation...
  6. pmc Preferential recruitment of CCR6-expressing Th17 cells to inflamed joints via CCL20 in rheumatoid arthritis and its animal model
    Keiji Hirota
    Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606 8507, Japan
    J Exp Med 204:2803-12. 2007
    ..These results indicate that CCR6 expression contributes to Th17 cell function in autoimmune disease, especially in autoimmune arthritis such as RA...
  7. pmc Enhanced autoimmunity, arthritis, and encephalomyelitis in mice with a reduced oxidative burst due to a mutation in the Ncf1 gene
    Malin Hultqvist
    Section for Medical Inflammation Research, Lund University, SE 22184 Lund, Sweden
    Proc Natl Acad Sci U S A 101:12646-51. 2004
    ....
  8. pmc Dipeptidyl peptidase I activates neutrophil-derived serine proteases and regulates the development of acute experimental arthritis
    April M Adkison
    Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri, USA
    J Clin Invest 109:363-71. 2002
    ..These results implicate DPPI and polymorphonuclear neutrophil-derived serine proteases in the regulation of cytokine production at sites of inflammation...
  9. pmc Mast cell deficiency in Kit(W-sh) mice does not impair antibody-mediated arthritis
    Joseph S Zhou
    Department of Medicine, Harvard Medical School, and Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Exp Med 204:2797-802. 2007
    ..Thus, a conclusion for an absolute mast cell role in a pathobiologic process requires evidence from both strains...
  10. ncbi Utility of animal models for identification of potential therapeutics for rheumatoid arthritis
    M Hegen
    Inflammation Discovery Research, Wyeth Research, Cambridge, MA 02140 2311, USA
    Ann Rheum Dis 67:1505-15. 2008
    ....
  11. ncbi Gamma/delta T cells are the predominant source of interleukin-17 in affected joints in collagen-induced arthritis, but not in rheumatoid arthritis
    Yoshinaga Ito
    Center for Innovation in Immunoregulative Technology and Therapeutics, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Arthritis Rheum 60:2294-303. 2009
    ..The involvement of IL-17-producing gamma/delta T cells in SKG mice with autoimmune arthritis and patients with rheumatoid arthritis (RA) was also investigated...
  12. pmc Bone destruction in arthritis
    E M Gravallese
    Department of Medicine, Beth Israel Deaconess Medical Center, New England Baptist Bone and Joint Institute, Harvard Institutes of Medicine, 4 Blackfan Circle, Room 241, Boston, MA 02115, USA
    Ann Rheum Dis 61:ii84-6. 2002
    ....
  13. ncbi Cathepsin K-dependent toll-like receptor 9 signaling revealed in experimental arthritis
    Masataka Asagiri
    Department of Cell Signaling, Graduate School, Tokyo Medical and Dental University, Tokyo 113 8549, Japan
    Science 319:624-7. 2008
    ..These results suggest that cathepsin K plays an important role in the immune system and may serve as a valid therapeutic target in autoimmune diseases...
  14. ncbi How interferon-gamma keeps autoimmune diseases in check
    Hilde Kelchtermans
    Laboratory of Immunobiology, Rega Institute for Medical Research, University of Leuven, Leuven, Belgium
    Trends Immunol 29:479-86. 2008
    ..We conclude that endogenous production of IFN-gamma during inflammatory and autoimmune diseases should be considered as a process with bidirectional immunoregulatory consequences, often resulting in moderation of pathology...
  15. ncbi Efficient new cationic liposome formulation for systemic delivery of small interfering RNA silencing tumor necrosis factor alpha in experimental arthritis
    Maroun Khoury
    INSERM U475 and University of Montpellier I, Montpellier, France
    Arthritis Rheum 54:1867-77. 2006
    ..The aim of this study was to determine the therapeutic effect of systemic administration of TNFalpha siRNA in an experimental model of RA, optimizing its delivery using new liposome formulations...
  16. ncbi Expression of mouse HtrA1 serine protease in normal bone and cartilage and its upregulation in joint cartilage damaged by experimental arthritis
    Akiho Tsuchiya
    Division of Gene Function in Animals, Nara Institute of Science and Technology, 8916 5 Takayama, Ikoma, Nara 630 0192, Japan
    Bone 37:323-36. 2005
    ..HtrA1 expression pattern during bone and cartilage development and in articular cartilage affected by experimental arthritis. HtrA1 is not expressed in mesenchymal or cartilage condensations before initiation of ossification...
  17. pmc Divergent pro- and antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation
    Craig A Murphy
    Discovery Research, DNAX Research Inc, Palo Alto, CA 94304, USA
    J Exp Med 198:1951-7. 2003
    ..The data presented here indicate that IL-23 is an essential promoter of end-stage joint autoimmune inflammation, whereas IL-12 paradoxically mediates protection from autoimmune inflammation...
  18. pmc Collagen-induced arthritis in C57BL/6 mice is associated with a robust and sustained T-cell response to type II collagen
    Julia J Inglis
    Kennedy Institute of Rheumatology, Imperial College London, 1 Aspenlea Road, London W6 8LH, UK
    Arthritis Res Ther 9:R113. 2007
    ....
  19. ncbi Inhibition of endogenous TGF-beta during experimental osteoarthritis prevents osteophyte formation and impairs cartilage repair
    Alwin Scharstuhl
    Rheumatology Research Laboratory, Department of Rheumatology, University Medical Center, Nijmegen, The Netherlands
    J Immunol 169:507-14. 2002
    ..In conclusion, we show for the first time that endogenous TGF-beta is a crucial factor in the process of osteophyte formation and has an important function in protection against cartilage loss...
  20. ncbi Invariant NKT cells produce IL-17 through IL-23-dependent and -independent pathways with potential modulation of Th17 response in collagen-induced arthritis
    Y Yoshiga
    Division of Clinical Immunology, Major of Advanced Biomedical Applications, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan
    Int J Mol Med 22:369-74. 2008
    ..Our findings indicate that iNKT cells are producers and activators of IL-17 via IL-23- dependent and -independent pathways, suggesting that they are key cells in the pathogenesis of CIA through IL-17...
  21. ncbi Implication of cartilage intermediate layer protein in cartilage destruction in subsets of patients with osteoarthritis and rheumatoid arthritis
    J Tsuruha
    St Marianna University School of Medicine, Kawasaki, Japan
    Arthritis Rheum 44:838-45. 2001
    ....
  22. ncbi CD25+ cell depletion hastens the onset of severe disease in collagen-induced arthritis
    Mary E Morgan
    Leiden University Medical Center, Leiden, The Netherlands
    Arthritis Rheum 48:1452-60. 2003
    ..We wished to evaluate their potential for influencing systemic and chronic joint inflammation by investigating their involvement in collagen-induced arthritis (CIA)...
  23. ncbi Interleukin-1 drives pathogenic Th17 cells during spontaneous arthritis in interleukin-1 receptor antagonist-deficient mice
    Marije I Koenders
    Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Arthritis Rheum 58:3461-70. 2008
    ..In this study, the role of Th17 cells and the effect of neutralization of IL-17, IL-1, and tumor necrosis factor alpha (TNFalpha) were investigated in this IL-1-driven murine arthritis model...
  24. ncbi Antiinflammatory and analgesic effects of somatostatin released from capsaicin-sensitive sensory nerve terminals in a Freund's adjuvant-induced chronic arthritis model in the rat
    Zsuzsanna Helyes
    Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Pecs, H 7643 Pecs, Szigeti u 12, Hungary
    Arthritis Rheum 50:1677-85. 2004
    ..This study was undertaken to examine this systemic "sensocrine" function of neuronally derived somatostatin in chronic inflammation in the Freund's complete adjuvant (CFA)-induced arthritis model...
  25. ncbi Magnetic resonance imaging can accurately assess the long-term progression of knee structural changes in experimental dog osteoarthritis
    C Boileau
    Osteoarthritis Research Unit, University of Montreal Hospital Centre, Notre Dame Hospital, 1560 Sherbrooke Street East, Montreal, Quebec, Canada
    Ann Rheum Dis 67:926-32. 2008
    ..In this study, we investigated the reliability of quantitative MRI in assessing knee OA structural changes in the experimental anterior cruciate ligament (ACL) dog model of OA...
  26. ncbi The therapeutic activity of low-dose irradiation on experimental arthritis depends on the induction of endogenous regulatory T cell activity
    Ling Weng
    Kennedy Institute of Rheumatology, Imperial College, London, UK
    Ann Rheum Dis 69:1519-26. 2010
    ..In the present work it is demonstrated that partial myeloablation induces a relative expansion of T(regs) that is sufficient to mediate immunological tolerance...
  27. ncbi Mice lacking mature T and B lymphocytes develop arthritic lesions after immunization with type II collagen
    D Plows
    Laboratory of Molecular Genetics, Hellenic Pasteur Institute, Athens, Greece
    J Immunol 162:1018-23. 1999
    ..We conclude that adaptive immune responses are not the only arthritogenic mechanism and hypothesize that the nonantigenic properties of type II collagen can also lead to arthritis...
  28. ncbi Treatment with a neutralizing anti-murine interleukin-17 antibody after the onset of collagen-induced arthritis reduces joint inflammation, cartilage destruction, and bone erosion
    Erik Lubberts
    University Medical Center Nijmegen, Nijmegen, The Netherlands
    Arthritis Rheum 50:650-9. 2004
    ..This T cell cytokine is implicated in the initiation phase of arthritis. However, the role of IL-17 during the effector phase of arthritis has still not been identified; this was the objective of the present study...
  29. ncbi Folate-targeted imaging of activated macrophages in rats with adjuvant-induced arthritis
    Mary Jo Turk
    Purdue University, West Lafayette, Indiana 47907, USA
    Arthritis Rheum 46:1947-55. 2002
    ..To determine whether overexpression of the high-affinity folate receptor (FR) on activated macrophages can be exploited to selectively target imaging agents to sites of inflammation in rats with adjuvant-induced arthritis (AIA)...
  30. ncbi Association of arthritis with a gene complex encoding C-type lectin-like receptors
    Johnny C Lorentzen
    Department of Medicine, Rheumatology Unit, Karolinska Institutet, Karolinska University Hospital, S 17176 Stockholm, Sweden
    Arthritis Rheum 56:2620-32. 2007
    ..To identify susceptibility genes in a rat model of rheumatoid arthritis (RA) and to determine whether the corresponding human genes are associated with RA...
  31. ncbi The chemokine receptors CXCR1/CXCR2 modulate antigen-induced arthritis by regulating adhesion of neutrophils to the synovial microvasculature
    Fernanda M Coelho
    Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
    Arthritis Rheum 58:2329-37. 2008
    ..We undertook this study to investigate the role of these receptors in mediating neutrophil adhesion, subsequent migration, and neutrophil-dependent hypernociception in a murine model of monarticular antigen-induced arthritis (AIA)...
  32. pmc Exacerbation of collagen-induced arthritis by oligoclonal, IL-17-producing gamma delta T cells
    Christina L Roark
    Integrated Department of Immunology, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Immunol 179:5576-83. 2007
    ..A decrease in total IgG and IgG2a anti-collagen Abs was also seen. These results suggest that Vgamma4/Vdelta4(+) gammadelta T cells exacerbate CIA through their production of IL-17...
  33. ncbi Gait analysis as an objective measure in a chronic pain model
    Paul Coulthard
    University Dental Hospital of Manchester, Higher Cambridge Street, Manchester, M15 6FH, UK
    J Neurosci Methods 116:197-213. 2002
    ..These behavioural changes were significant at a very early stage (day 10), before the development of physical deformities and increase in paw volume and might permit an earlier detection of pain than other models...
  34. pmc Interleukin-10 expression and chemokine regulation during the evolution of murine type II collagen-induced arthritis
    T Kasama
    Department of Pathology, University of Michigan Medical School, Ann Arbor 48109, USA
    J Clin Invest 95:2868-76. 1995
    ..These data suggest that MIP-1 alpha and MIP-2 play a crucial role in the initiation and maintenance, while IL-10 appears to play a regulatory role during the development of experimental arthritis.
  35. pmc Green tea protects rats against autoimmune arthritis by modulating disease-related immune events
    Hong Ro Kim
    Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Nutr 138:2111-6. 2008
    ..Thus, green tea induced changes in arthritis-related immune responses. We suggest further systematic exploration of dietary supplementation with PGT as an adjunct nutritional strategy for the management of RA...
  36. ncbi Comparative study of flavonoids in experimental models of inflammation
    Alejandra Ester Rotelli
    Catedra de Farmacologia, Facultad de Quimica, Bioquimica y Farmacia, Universidad Nacional de San Luis, Chacabuco y Pedernera, 5700 San Luis, Argentina
    Pharmacol Res 48:601-6. 2003
    ..The most important compound in reducing paw oedema induced by carrageenan was quercetin...
  37. ncbi Lactobacillus casei suppresses experimental arthritis by down-regulating T helper 1 effector functions
    Jae Seon So
    Department of Life Sciences, Gwangju Institute of Science and Technology, 1 Oryong dong, Buk Gu, Gwangju 500 712, Republic of Korea
    Mol Immunol 45:2690-9. 2008
    ..Our results suggest that oral administration of L. casei suppresses the type II collagen-reactive effector function of Th1-type cellular and humoral immune responses in arthritic inflammation...
  38. ncbi Particularities of the vasculature can promote the organ specificity of autoimmune attack
    Bryce A Binstadt
    Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Immunol 7:284-92. 2006
    ..We propose that regionally distinct vascular properties 'interface' with immune effector pathways to foster organ-specific autoimmune damage, perhaps explaining why arthritis accompanies many human infectious and autoimmune disorders...
  39. ncbi Leptin signaling deficiency impairs humoral and cellular immune responses and attenuates experimental arthritis
    Nathalie Busso
    Laboratory of Rheumatology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    J Immunol 168:875-82. 2002
    ..In conclusion, leptin contributes to the mechanisms of joint inflammation in Ag-induced arthritis by regulating both humoral and cell-mediated immune responses...
  40. ncbi Dominant-negative inhibitors of soluble TNF attenuate experimental arthritis without suppressing innate immunity to infection
    Jonathan Zalevsky
    Xencor, Monrovia, CA 91016, USA
    J Immunol 179:1872-83. 2007
    ....
  41. ncbi B7RP-1 blockade ameliorates autoimmunity through regulation of follicular helper T cells
    Yi Ling Hu
    Department of Inflammation, Amgen, Inc, Thousand Oaks, CA 91320, USA
    J Immunol 182:1421-8. 2009
    ..These findings further support the role of ICOS in autoimmunity and suggest that the expansion of the T(FH) cell pool is an important mechanism by which ICOS regulates Ab production...
  42. ncbi Synergistic protection against cartilage destruction by low dose prednisolone and interleukin-10 in established murine collagen arthritis
    L A Joosten
    Department of Rheumatology, University Hospital Nijmegen, The Netherlands
    Inflamm Res 48:48-55. 1999
    ..To investigate potential synergy of low dosages glucocorticosteroids (GC's) and interleukin-10 (IL-10), using established murine collagen-induced arthritis (CIA) as a model...
  43. ncbi Effectiveness of the soluble form of the interleukin-1 receptor accessory protein as an inhibitor of interleukin-1 in collagen-induced arthritis
    R L Smeets
    University Medical Center Nijmegen, Nijmegen, The Netherlands
    Arthritis Rheum 48:2949-58. 2003
    ....
  44. ncbi Complete remission of experimental arthritis by joint targeting of glucocorticoids with long-circulating liposomes
    Josbert M Metselaar
    Utrecht Institute of Pharmaceutical Sciences, Utrecht, The Netherlands
    Arthritis Rheum 48:2059-66. 2003
    To increase the therapeutic activity of glucocorticoids in experimental arthritis by encapsulation in long-circulating polyethylene glycol liposomes, which have shown the ability to preferentially accumulate in inflamed joints after ..
  45. pmc The role of substance P in microvascular responses in murine joint inflammation
    Julie Keeble
    Centre for Cardiovascular Biology and Medicine, New Hunt s House, King s College London, Guy s Campus, London SE1 1UL
    Br J Pharmacol 144:1059-66. 2005
    ....
  46. ncbi Liposomal superoxide dismutases and their use in the treatment of experimental arthritis
    M Eugénia M Cruz
    Instituto Nacional de Engenharia e Tecnologia Industrial, Departmento de Biotecnologia, Lisbon, Portugal
    Methods Enzymol 391:395-413. 2005
    ..Different methodologies for the preparation of SOD and Ac-SOD liposomal formulations (conventional and long circulating) have been established and are described in detail here...
  47. ncbi Antiinflammatory effect of A3 adenosine receptor agonists in murine autoimmune arthritis models
    Ehud Baharav
    Can Fite BioPharma Ltd, 10 Bareket Street, Kiryat Matalon, Petach Tikva, Tel Aviv, Israel 49170
    J Rheumatol 32:469-76. 2005
    ..We evaluated its therapeutic potential and antiinflammatory effects in 3 murine models of adjuvant induced arthritis (AIA)...
  48. pmc Apremilast, a novel PDE4 inhibitor, inhibits spontaneous production of tumour necrosis factor-alpha from human rheumatoid synovial cells and ameliorates experimental arthritis
    Fiona E McCann
    The Kennedy Institute of Rheumatology, Imperial College London, 65 Aspenlea Road, London, W6 8LH, UK
    Arthritis Res Ther 12:R107. 2010
    ..We assessed the anti-inflammatory effects of a novel PDE4 inhibitor, apremilast, in human synovial cells from rheumatoid arthritis (RA) patients, as well as two murine models of arthritis...
  49. ncbi Animal models of arthritis: relevance to human disease
    A Bendele
    BoulderPATH, Inc, Boulder, Colorado 80309, USA
    Toxicol Pathol 27:134-42. 1999
    ..Efficacy data and features of the various models of RA and OA are discussed with emphasis on their proven relevance to human disease...
  50. ncbi S100A8 causes a shift toward expression of activatory Fcγ receptors on macrophages via toll-like receptor 4 and regulates Fcγ receptor expression in synovium during chronic experimental arthritis
    Peter L van Lent
    Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Arthritis Rheum 62:3353-64. 2010
    ..This study was undertaken to study the active involvement of S100A8, S100A9, and S100A8/S100A9 in FcγR regulation in murine macrophages and synovium during AIA...
  51. ncbi Activated CD4+CD25+ regulatory T cells inhibit osteoclastogenesis and collagen-induced arthritis
    H Kelchtermans
    Laboratory of Immunobiology, Rega Institute, Leuven, Belgium
    Ann Rheum Dis 68:744-50. 2009
    ..A similar situation has been described in collagen-induced arthritis (CIA). In this study, it was investigated whether a single transfer of polyclonally activated T(reg) cells inhibits CIA and osteoclastogenesis...
  52. pmc Functional analysis of an arthritogenic synovial fibroblast
    Vassilis Aidinis
    Institute of Immunology, Biomedical Sciences Research Center Alexander Fleming, Athens, Greece
    Arthritis Res Ther 5:R140-57. 2003
    ..Our findings support an aggressive role for the SF in the development of the disease and reinforce the perspective of a transformed-like character of the SF...
  53. ncbi The molecular signature of oxidative metabolism and the mode of macrophage activation determine the shift from acute to chronic disease in experimental arthritis: critical role of interleukin-12p40
    Nozomi Takahashi
    Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Arthritis Rheum 58:3471-84. 2008
    ..The objective of this study was to identify genes and pathways that determine disease progression based on gene expression profiling in this model...
  54. pmc TLR2 modulates inflammation in zymosan-induced arthritis in mice
    Matthias E Frasnelli
    Laboratoire de Rhumatologie, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Arthritis Res Ther 7:R370-9. 2005
    ..These results show that ZIA is more prolonged than was originally described and involves both the innate and acquired immune pathways. C3 does not seem to have a major role in this model of joint inflammation...
  55. pmc A crucial role for tumor necrosis factor receptor 1 in synovial lining cells and the reticuloendothelial system in mediating experimental arthritis
    Onno J Arntz
    Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Radboud University Nijmegen Medical Centre, 6525 GA Nijmegen, The Netherlands
    Arthritis Res Ther 12:R61. 2010
    ..TNFR1) in mediating the TNFalpha effects in RA has not been elucidated and conflicting data exist in experimental arthritis models...
  56. ncbi Anti-neuropilin-1 peptide inhibition of synoviocyte survival, angiogenesis, and experimental arthritis
    Jin Sun Kong
    The Catholic University of Korea, Seoul, South Korea
    Arthritis Rheum 62:179-90. 2010
    ..To delineate the role of neuropilin-1 (NP-1), a vascular endothelial growth factor receptor (VEGFR), in rheumatoid inflammation and to determine whether blockade of NP-1 could suppress synoviocyte survival and angiogenesis...
  57. ncbi The mouse model of collagen-induced arthritis
    David D Brand
    Department of Medicine, University of Tennessee Health Sciences Center, Memphis, USA
    Methods Mol Med 102:295-312. 2004
    ....
  58. ncbi Blocking the effects of IL-1 in rheumatoid arthritis protects bone and cartilage
    S B Abramson
    Department of Rheumatology, Hospital for Joint Diseases, New York University of Medicine, 301 East 17th Street, New York, NY 10003, USA
    Rheumatology (Oxford) 41:972-80. 2002
    ..These results demonstrate that blocking IL-1 protects bone and cartilage from progressive destruction in RA...
  59. ncbi Lactobacillus casei potentiates induction of oral tolerance in experimental arthritis
    Jae Seon So
    Department of Life Sciences, Gwangju Institute of Science and Technology GIST, Gwangju 500 712, Republic of Korea
    Mol Immunol 46:172-80. 2008
    ..clinical symptoms, paw swelling, lymphocyte infiltration and destruction of cartilage tissues of experimental arthritis than the rats treated with CII alone...
  60. ncbi Quantitative analysis of micro-CT imaging and histopathological signatures of experimental arthritis in rats
    Matthew D Silva
    Millennium Pharmaceuticals Inc, 45 Sidney Street, Cambridge, MA 02139, USA
    Mol Imaging 3:312-8. 2004
    ....
  61. ncbi Schistosoma mansoni infection reduces severity of collagen-induced arthritis via down-regulation of pro-inflammatory mediators
    Yoshio Osada
    Department of Immunology and Parasitology, University of Occupational and Environmental Health, Yahatanishi ku, Kitakyushu, Japan
    Int J Parasitol 39:457-64. 2009
    ....
  62. ncbi Prostacyclin antagonism reduces pain and inflammation in rodent models of hyperalgesia and chronic arthritis
    Anne Marie Pulichino
    Merck Frosst Centre for Therapeutic Research, Kirkland, Quebec, Canada
    J Pharmacol Exp Ther 319:1043-50. 2006
    ..The results also suggest that the inhibition of PGI(2) synthesis by NSAIDs and COX-2 inhibitors, in addition to that of PGE(2), contributes to their efficacy in treating the signs of arthritis...
  63. ncbi Clinical and immunomodulatory effects of fun-boi, an herbal medicine, on collagen-induced arthritis in vivo
    A Niizawa
    Department of Japanese Oriental Medicine, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Toyama, Japan
    Clin Exp Rheumatol 21:57-62. 2003
    ..The objective of this study was therefore to evaluate the efficacy of Fun-boi against arthritis and its effect on the immune system...
  64. ncbi Increased corticosterone pulse frequency during adjuvant-induced arthritis and its relationship to alterations in stress responsiveness
    R J Windle
    Department of Medicine, University of Bristol, Bristol Royal Infirmary, Bristol, UK
    J Neuroendocrinol 13:905-11. 2001
    ..v. lipopolysaccharide. Thus, altered basal pulse frequency is a major factor influencing HPA activation during acute psychological stress...
  65. ncbi Interleukin-23 promotes Th17 differentiation by inhibiting T-bet and FoxP3 and is required for elevation of interleukin-22, but not interleukin-21, in autoimmune experimental arthritis
    Adriana M C Mus
    Erasmus MC, University Medical Center, 3015 CE Rotterdam, The Netherlands
    Arthritis Rheum 62:1043-50. 2010
    ..To examine the role of interleukin-23 (IL-23) in subgroup polarization of IL-17A-positive and/or interferon-gamma (IFNgamma)-positive T cells in autoimmune disease-prone DBA/1 mice with and without collagen-induced arthritis...
  66. ncbi Expression of osteopontin at sites of bone erosion in a murine experimental arthritis model of collagen-induced arthritis: possible involvement of osteopontin in bone destruction in arthritis
    Shiro Ohshima
    Osaka University Medical School, Suita City, Osaka, Japan
    Arthritis Rheum 46:1094-101. 2002
    To investigate the involvement of osteopontin (OPN) in bone destruction in a murine experimental arthritis model of collagen-induced arthritis (CIA).
  67. ncbi Inhibition of fractalkine ameliorates murine collagen-induced arthritis
    Toshihiro Nanki
    Department of Medicine and Rheumatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    J Immunol 173:7010-6. 2004
    ..Our results suggest that anti-FKN mAb ameliorates arthritis by inhibiting infiltration of inflammatory cells into the synovium. Thus, FKN can be a new target molecule for the treatment of RA...
  68. ncbi Effects of combination M40403 and dexamethasone therapy on joint disease in a rat model of collagen-induced arthritis
    Salvatore Cuzzocrea
    University of Messina, Messina, Italy
    Arthritis Rheum 52:1929-40. 2005
    ..To investigate the effects of combination therapy with M40403, a superoxide dismutase mimetic (SODm), and dexamethasone (DEX) on collagen-induced arthritis (CIA) in rats...
  69. pmc Protective effect of an extract from Ascaris suum in experimental arthritis models
    Francisco Airton Castro Rocha
    Department of Internal Medicine, Faculty of Medicine, Federal University of Ceara, Fortaleza 60115281, Brazil
    Infect Immun 76:2736-45. 2008
    ..This A. suum effect is species independent and functions orally and parenterally. The results show clinical and structural benefits when A. suum extract is given either prophylactically or therapeutically...
  70. ncbi IL-1-independent role of IL-17 in synovial inflammation and joint destruction during collagen-induced arthritis
    E Lubberts
    Rheumatology Research Laboratory, Department of Rheumatology, University Medical Center St Radboud, Nijmegen, The Netherlands
    J Immunol 167:1004-13. 2001
    ..These findings suggest IL-17 to be a novel target for the treatment of destructive arthritis and may have implications for tissue destruction in other autoimmune diseases...
  71. ncbi Cu/Zn superoxide dismutase plays important role in immune response
    Moshe Marikovsky
    Department of Animal Sciences, Faculty of Agricultural, Food, and Environmental Quality Sciences, Hebrew University of Jerusalem, Rehovot, Israel
    J Immunol 170:2993-3001. 2003
    ....
  72. ncbi Potent adjuvant effect by anti-CD40 in collagen-induced arthritis. Enhanced disease is accompanied by increased production of collagen type-II reactive IgG2a and IFN-gamma
    A C Tellander
    Active Biotech Research AB, Lund, Sweden
    J Autoimmun 14:295-302. 2000
    ..In conclusion, our results indicate that the level of CD40 activation during the induction of an autoimmune response may determine the severity of the resulting disease...
  73. pmc Amelioration of rat adjuvant-induced arthritis by Met-RANTES
    Shiva Shahrara
    Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Arthritis Rheum 52:1907-19. 2005
    ..The aim of this study was to investigate whether Met-RANTES could ameliorate adjuvant-induced arthritis (AIA) in the rat...
  74. ncbi Anticytokine treatment of established type II collagen-induced arthritis in DBA/1 mice: a comparative study using anti-TNFalpha, anti-IL-1alpha/beta and IL-1Ra
    Leo A B Joosten
    University Hospital Nijimegen, Nijimegen, The Netherlands
    Arthritis Rheum 58:S110-22. 2008
    ..To examine the role of tumor necrosis factor alpha (TNF alpha), interleukin-1 alpha (IL-1 alpha), and IL-1 beta in collagen-induced arthritis (CIA), immediately after onset and during the phase of established arthritis...
  75. ncbi Suppression of immune induction of collagen-induced arthritis in IL-17-deficient mice
    Susumu Nakae
    Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    J Immunol 171:6173-7. 2003
    ..Thus, these observations suggest that IL-17 plays a crucial role in the development of CIA by activating autoantigen-specific cellular and humoral immune responses...
  76. pmc The role of regulatory T cells in antigen-induced arthritis: aggravation of arthritis after depletion and amelioration after transfer of CD4+CD25+ T cells
    Oliver Frey
    Institut fur Pathologie, Friedrich Schiller Universitat, Jena, Germany
    Arthritis Res Ther 7:R291-301. 2005
    ..However, transferred Treg cells appear to be unable to counteract established acute or chronic inflammation. This is of considerable importance for the timing of Treg cell transfer in potential therapeutic applications...
  77. pmc Transcription factor T-bet regulates inflammatory arthritis through its function in dendritic cells
    Jingsong Wang
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    J Clin Invest 116:414-21. 2006
    ..T-bet provides an attractive new target for the development of novel therapeutics for inflammatory arthritis...
  78. ncbi Complement activation by both classical and alternative pathways is critical for the effector phase of arthritis
    Max Albert Hietala
    Department of Medical Biochemistry, Goteborg University, Goteborg, Sweden
    Eur J Immunol 34:1208-16. 2004
    ..We conclude that both the classical and the alternative pathways of complement activation are involved in the effector phase of arthritis...
  79. ncbi The balance of Th1/Th2 cytokines in rheumatoid arthritis
    H Schulze-Koops
    Nikolaus Fiebiger Center for Molecular Medicine, Clinical Research Group III and Department of Internal Medicine III and Institute for Clinical Immunology, Glueckstrasse 6, Erlangen, 91054, Germany
    Best Pract Res Clin Rheumatol 15:677-91. 2001
    ..The accumulating evidence for a T helper type 1 driven inflammation and the implications for future therapy are delineated...
  80. ncbi A highly selective inhibitor of I kappa B kinase, BMS-345541, blocks both joint inflammation and destruction in collagen-induced arthritis in mice
    Kim W McIntyre
    Bristol Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey 08543, USA
    Arthritis Rheum 48:2652-9. 2003
    ....
  81. pmc Liposomal targeting of glucocorticoids to synovial lining cells strongly increases therapeutic benefit in collagen type II arthritis
    J M Metselaar
    Department of Pharmaceutics, Utrecht Institute of Pharmaceutical Sciences, The Netherlands
    Ann Rheum Dis 63:348-53. 2004
    ....
  82. pmc TNF-alpha is crucial for the development of autoimmune arthritis in IL-1 receptor antagonist-deficient mice
    Reiko Horai
    Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    J Clin Invest 114:1603-11. 2004
    ..These findings suggest that IL-1 receptor antagonist deficiency in T cells disrupts homeostasis of the immune system and that TNF-alpha plays an important role in activating T cells through induction of OX40...
  83. ncbi Suppression of collagen-induced arthritis by natural killer T cell activation with OCH, a sphingosine-truncated analog of alpha-galactosylceramide
    Asako Chiba
    National Institute of Neuroscience, NCNP and Juntendo University School of Medicine, Tokyo, Japan
    Arthritis Rheum 50:305-13. 2004
    ..Thus, OCH may be a potential agent for the treatment of Th1-mediated autoimmune diseases. This study was designed to evaluate the protective effects of OCH on collagen-induced arthritis (CIA) in mice...
  84. pmc IFNgamma deficient C57BL/6 (H-2b) mice develop collagen induced arthritis with predominant usage of T cell receptor Vbeta6 and Vbeta8 in arthritic joints
    C Q Chu
    Department of Internal Medicine, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Ann Rheum Dis 62:983-90. 2003
    ..Transgenic deficiency in interferon gamma (IFNgamma) or IFNgamma receptor makes resistant strains of mice bearing H-2(b) or H-2(d) susceptible to collagen induced arthritis (CIA)...
  85. ncbi Type II collagen autoimmunity in a mouse model of human rheumatoid arthritis
    Young Gyu Cho
    Department of Medicine, Division of Rheumatology, Center for Rheumatoid Diseases and Rheumatism Research Center RhRC, Catholic Research Institutes of Medical Sciences, Catholic University of Korea, Seoul, Republic of Korea
    Autoimmun Rev 7:65-70. 2007
    ..In the present report, we summarize the available information on anti-CII immunity and discuss recent updates regarding pathogenesis in the CIA model, including the role of Th17 cells...
  86. ncbi Interferon-gamma protects against the development of structural damage in experimental arthritis by regulating polymorphonuclear neutrophil influx into diseased joints
    Anwen S Williams
    Wales College of Medicine, Cardiff University, Heath Park, Cardiff, UK
    Arthritis Rheum 56:2244-54. 2007
    ....
  87. pmc Critical roles for interleukin 1 and tumor necrosis factor alpha in antibody-induced arthritis
    Hong Ji
    Section on Immunology and Immunogenetics, Joslin Diabetes Center and Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    J Exp Med 196:77-85. 2002
    ..The variability in the requirement for TNF-alpha, reminiscent of that observed in treated rheumatoid arthritis patients, did not appear genetically programmed but related instead to subtle environmental changes...
  88. ncbi Cell therapy using allogeneic bone marrow mesenchymal stem cells prevents tissue damage in collagen-induced arthritis
    Andrea Augello
    Department of Oncology, Biology, and Genetics, University of Genoa, National Institute for Cancer Research, Genoa, Italy
    Arthritis Rheum 56:1175-86. 2007
    ..We explored the feasibility of using allogeneic MSCs as therapy for collagen-induced arthritis, a mouse model for human rheumatoid arthritis...
  89. ncbi Fibroblast growth factor-2 determines severity of joint disease in adjuvant-induced arthritis in rats
    Akihisa Yamashita
    Division of Pathophysiological and Experimental Pathology, Department of Pathology, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    J Immunol 168:450-7. 2002
    ..FGF-2 may prove to be a possible therapeutic target to treat subjects with RA...
  90. ncbi The cyclopentenone prostaglandin 15-deoxy-Delta(12,14)-prostaglandin J(2) attenuates the development of acute and chronic inflammation
    Salvatore Cuzzocrea
    Institute of Pharmacology, School of Medicine, University of Messina, Messina, Italy
    Mol Pharmacol 61:997-1007. 2002
    ..Thus, 15d-PGJ(2) reduces the development of acute and chronic inflammation. Therefore, the cyclopentenone prostaglandin 15d-PGJ(2) may be useful in the therapy of acute and chronic inflammation...
  91. ncbi Dual role of CCR2 during initiation and progression of collagen-induced arthritis: evidence for regulatory activity of CCR2+ T cells
    Hilke Bruhl
    Medical Policlinic, University of Munich, Pettenkoferstrasse 8a, 80336 Munich, Germany
    J Immunol 172:890-8. 2004
    ..These findings identify CCR2+ T cells as regulatory T cells and indicate that CCR2 also plays an important role in down-modulating an inflammatory response...
  92. ncbi An analog peptide that suppresses collagen-induced arthritis
    Linda K Myers
    Department of Pediatrics and Medicine, University of Tennessee, and from the Research Service of the Veterans Affairs Medical Center, Memphis, Tennessee, USA
    Am J Med Sci 327:212-6. 2004
    ..An analog peptide of CII recognized by T cells in the context of a human major histocompatibility complex molecule should have therapeutic significance for autoimmune arthritis...
  93. ncbi Splenic suppressor of cytokine signaling 3 transgene expression affects T cell responses and prevents development of collagen-induced arthritis
    Sharon Veenbergen
    Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Arthritis Rheum 58:3742-52. 2008
    ..The aim of this study was to investigate modulation of T cell immunity for the treatment of experimental arthritis, via enhanced expression of SOCS-3 in splenic antigen-presenting cells (APCs) obtained after intravenous ..
  94. ncbi A novel anti-inflammatory role for simvastatin in inflammatory arthritis
    Bernard P Leung
    Department of Immunology, Glasgow Royal Infirmary, University of Glasgow, Glasgow, United Kingdom
    J Immunol 170:1524-30. 2003
    ..These data clearly illustrate the therapeutic potential of statin-sensitive pathways in inflammatory arthritis...
  95. pmc Developmental stage, phenotype, and migration distinguish naive- and effector/memory-like CD4+ regulatory T cells
    Jochen Huehn
    Experimentelle Rheumatologie, Medizinische Klinik, Charite, Humboldt Universitaet, Schumannstr 21 22, 10117 Berlin, Germany
    J Exp Med 199:303-13. 2004
    ..Accordingly, alphaE -expressing cells were found to be the most potent suppressors of inflammatory processes in disease models such as antigen-induced arthritis...
  96. ncbi Inhibition of synovial hyperplasia, rheumatoid T cell activation, and experimental arthritis in mice by sulforaphane, a naturally occurring isothiocyanate
    Jin Sun Kong
    Catholic University of Korea, Seoul, South Korea
    Arthritis Rheum 62:159-70. 2010
    ..To investigate whether sulforaphane (SFN), an isothiocyanate derived from cruciferous vegetables such as broccoli, regulates synoviocyte hyperplasia and T cell activation in rheumatoid arthritis (RA)...
  97. ncbi Interleukin-6 blockade suppresses autoimmune arthritis in mice by the inhibition of inflammatory Th17 responses
    Minoru Fujimoto
    National Institute of Biomedical Innovation, Osaka, Japan
    Arthritis Rheum 58:3710-9. 2008
    ....
  98. ncbi Joint damage and inflammation in c-Jun N-terminal kinase 2 knockout mice with passive murine collagen-induced arthritis
    Zuoning Han
    University of California San Diego School of Medicine, La Jolla 92093, USA
    Arthritis Rheum 46:818-23. 2002
    ..The present study was undertaken to investigate whether selective loss of JNK-2 function decreases joint destruction in JNK-2 knockout mice, in order to determine the role of this isoform in inflammatory arthritis...
  99. ncbi IL-10-deficient B10.Q mice develop more severe collagen-induced arthritis, but are protected from arthritis induced with anti-type II collagen antibodies
    - Johansson AC
    Section for Medical Inflammation Research, University of Lund, Lund, Sweden
    J Immunol 167:3505-12. 2001
    ..These data emphasize the importance of studying IL-10 in a defined genetic context in vivo, to understand its role in a complex disease like arthritis...
  100. ncbi Cytokine production profile of splenocytes derived from zymosan A-treated SKG mice developing arthritis
    K Kobayashi
    Department of Allergy, Pharmaceutical Research Center, Kyowa Hakko Kogyo Co, Ltd, 1188 Shimotogari, Shizuoka ken, 411 8731, Japan
    Inflamm Res 55:335-41. 2006
    ..The purpose of this study was to investigate the cytokine production from splenocytes in SKG mice developing arthritis under the SPF condition...
  101. ncbi Behavior and severity of adjuvant arthritis in four rat strains
    M Dimitrijevic
    Immunology Research Center Branislav Jankovic, 11221 Belgrade, Yugoslavia
    Brain Behav Immun 15:255-65. 2001
    ....

Research Grants62

  1. MAPPING OF ARTHRITIS SUSCEPTIBILITY GENES
    Tibor T Glant; Fiscal Year: 2013
    ..In the genomic research history of experimental arthritis, we have identified probably the smallest size of arthritis-associated genomic regions, and now we are in ..
  2. Innate and Adaptive Immune Mechanisms in Arthritis
    RICHARD J BUCALA; Fiscal Year: 2013
    ..We showed that anti-MIF is protective in experimental arthritis and we reported on MIF's ability to override glucocorticoid immunosuppression, induce sustained ..
  3. Pro-inflammatory role of megakaryocytes in arthritis
    Peter A Nigrovic; Fiscal Year: 2013
    ..The present submission provides evidence linking megakaryocytes directly to murine experimental arthritis. Among mature hematopoietic lineages, the stem cell factor/KitL receptor Kit is expressed most prominently ..
  4. Identification of CNS-homing peptides for therapeutic use in multiple sclerosis
    Kamal D Moudgil; Fiscal Year: 2013
    ..We believe that the results of this study would advance our understanding of the pathogenesis of EAE/MS, and pave the way for designing novel peptide-directed therapeutics for MS through translational research. . ..
  5. CYTOKINE REGULATION IN EXPERIMENTAL ARTHRITIS
    Alison Finnegan; Fiscal Year: 2013
    ..These studies aim to develop novel insights into the autoimmune disease process that will facilitate the diagnosis and treatment of RA. ..
  6. Therapeutic Role for P21 in Suppressing IL-1 Beta Mediated Pathologies
    HARRIS R PERLMAN; Fiscal Year: 2013
    ..administration of a p21 peptide mimetic suppresses activation of macrophages and prevents development of experimental arthritis. Mechanistically, the increased activation in p21-/- macrophages is associated with the reduction in the ..
  7. Immune Suppression of Collagen Arthritis
    Linda K Myers; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: This R01 is a new application in which we use humanized mice bearing DRB1*0101 and DRB1*0401 transgenes and the collagen-induced arthritis (CIA) model to develop a collagen-based immunotherapy. ..
  8. Mechanisms of Rheumatoid Synovial Fibroblast Activation
    RICHARD J BUCALA; Fiscal Year: 2013
    ..We will define the phenotype of DDT-KO and MIF-DDT double-knockout (DKO) mice in experimental arthritis and compare them to MIF-KO and MIF receptor-KO (CD74-KO) mice...
  9. Chemokines in pathogenesis of Experimental Arthritis
    SEEMA SINGH AHUJA; Fiscal Year: 2010
    ..the following two Specific Aims : Aim #1 will test the hypothesis that the regulatory role of CCR2 in experimental arthritis is mediated in part via its effects on DCs and/or monocyte macrophage biology...
  10. Innate Immunity in Experimental Arthritis of Kininogen
    Robert Colman; Fiscal Year: 2007
    ..Fischer rats with variable degrees of kininogen cleavage I during experimental arthritis and systemic inflammation induced by PG-APS...
  11. alpha4beta1 Intergrin Signaling In Immunity And Arthritis
    GREGG JOSHUA SILVERMAN; Fiscal Year: 2010
    ..that the a4-paxillin interaction is involved in arthritis pathogenesis by examining the development of experimental arthritis in these mice. ...
  12. A Novel Immune Stimulatory Ligand in Autoimmunity-Associated Angiogenesis
    HENRY ISAAC MOSBERG; Fiscal Year: 2013
    ..is a signal transduction ligand that activates Th17 polarization and increases disease severity in experimental arthritis. Moreover, based on these data, we have rationally designed a prototypic small inhibitory molecule that ..
  13. Development of UTL-5b for Rheumatoid Arthritis: Mechanism of Action
    Jiajiu Shaw; Fiscal Year: 2007
    ..the proposed in vivo study; (3) To evaluate the anti-arthritic activity of UTL- 5b in the collagen-induced experimental arthritis model...
  14. MECHANISMS OF ANTIFOLATE EFFICACY IN ARTHRITIS
    Sarah Morgan; Fiscal Year: 2000
    ..The information obtained from the proposed research will enhance the understanding of the biochemical action of antifolates/antimetabolites that are effective in the treatment of human and animal arthritis. ..
  15. Novel xanthine oxidase inhibitor for arthritis
    Zsuzsanna Zsengeller; Fiscal Year: 2004
    ..In a Phase 2 SBIR, we will carry out a Phase IIa clinical investigation to establish the efficacy of AN-260 in reversing symptomatic clinical RA. ..
  16. IMMUNOLOGIC BASIS ENIVR MODULATION OF AUTOIM ARTHRITIS
    KAMAL MOUDGIL; Fiscal Year: 2001
    ....
  17. MULTIPURPOSE ARTHRITIS & MUSCULOSKELETAL DISEASE CENTER
    HARRY BLUESTEIN; Fiscal Year: 2000
    ..P.I., L. Feng, (Scripps) will dissect the role of the chemoattractant proteins IL-8 and MCP-1 in experimental arthritis. P.I., D. Green, (L.J.I.A.I...
  18. Lanthanides as Novel Anti-Arthritic Agents
    Christopher Evans; Fiscal Year: 2004
    ..A successful outcome to these studies will have identified the basis for a potential new, very inexpensive anti-rheumatic agent whose mode of action differs from that of existing drugs. ..
  19. HEAT SHOCK PROTEINS IN E COLI CELL ENVELOPE
    MARY LUCKEY; Fiscal Year: 1993
    ..These hsps are highly immunogenic: in pathogens such as Borrelia burgdorferi (lyme disease) and Mycobacterium tuberculosis (adjuvant arthritis in rats) the hsps are the dominant antigens in the host. ..
  20. MULTIPURPOSE ARTHRITIS & MUSCULOSKELETAL DISEASES CENTER
    JOHN WINFIELD; Fiscal Year: 2001
    ..to disease pathogenesis; immunosuppression; inciting agents in autoimmunity; inflammation in experimental arthritis and its therapy; biochemistry and cell biology of cartilage; pathophysiology of mechanical joint injury ..
  21. Membrane Proteins and Mycoplasma arthritidis
    LEIGH WASHBURN; Fiscal Year: 2006
    ..Although natural infections are now rare, experimental arthritis can be induced by intravenous or intraperitoneal injections...
  22. Cellular therapy of autoimmunity using antigen-expressing B cells
    KAMAL MOUDGIL; Fiscal Year: 2009
    ..The results of this study would help develop novel treatment regimens for arthritis and other autoimmune diseases. ..
  23. Novel Small Molecule Inhibitor of Rheumatoid Arthritis
    Jun Hayashi; Fiscal Year: 2009
    ..The ultimate goal is development of an effective drug candidate for these chronic inflammatory diseases that will be substantially more cost effective than the breakthrough biologics. ..
  24. Inosine pro-drug: novel therapy for arthritis
    Andrew Salzman; Fiscal Year: 2004
    ..The Specific Aims of this Fast-Track proposal are: Phase I: Establish that IMS reverses established experimental arthritis and is effective in combination with current clinical anti-arthritic therapies...
  25. Pyrin in Arthritis: Exression and Modulatory Role
    Arturo Diaz; Fiscal Year: 2004
    ..Aim 3: To determine whether wild type pyrin modulates inflammation and/or apoptosis in experimental arthritis and peritonitis produced in mouse models (mice that over-express human pyrin; pyrin deficient mice; mice ..
  26. The role of Mcl-1 in the macrophages and RA
    Richard Pope; Fiscal Year: 2007
    ..We propose to determine if the forced downregulation of Mcl-1 will ameliorate experimental arthritis, which would indicate that Mcl-1 is a contributor to the initiation and/or progression of arthritis...
  27. COLLAGEN INDUCED ARTHRITIS--SPECIFICITY OF T CELLS
    Ernest Brahn; Fiscal Year: 1992
    ..These studies should expand our understanding of T cell mediated processes in the pathogenesis of a chronic inflammatory synovitis...
  28. REGULATION OF INFLAMMATION IN EXPERIMENTAL ARTHRITIS
    JOHN SCHWAB; Fiscal Year: 1993
    ..Another specific aim is to characterize an interleukin 1 inhibitor produced by rat macrophages stimulated by PG-APS and to determine its role in regulation of joint inflammation induced by PG-APS...
  29. Mycoplasma Superantigen & RA MHC Susceptibility Alleles
    BARRY COLE; Fiscal Year: 2006
    ..arthritidis in these "humanized" mice and determine strategies to overcome the effect of the superantigen MAM in initiating disease pathogenesis by modification of the cytokine milieu. ..
  30. Celastrus: Immunologic Basis of Anti-Arthritic Activity
    Li Tong; Fiscal Year: 2006
    ..The results of this study would help in establishing a reliable scientific basis for use of Celastrus in autoimmune arthritis, and in developing better therapeutic approaches for patients with RA. ..
  31. AUTOIMMUNE ARTHRITIS DISEASE/PROTECTION BY T CELL CLONES
    Irun Cohen; Fiscal Year: 1991
    ..Treatment of established arthritis b. Vaccines prepared from arthritic rats. c. Passive transfer of vaccinated state. d. Anti-idiotypic T cells e. Effects of responses to antigens 4. Inhibition of arthritis using T cell defined epitopes..
  32. REGULATION OF AUTOIMMUNITY BY MODULATING ANTIGEN PROCESS
    KAMAL MOUDGIL; Fiscal Year: 2000
    ....
  33. CD44-MEDIATED ADHESION IN CHRONIC INFLAMMATORY DISEASE
    Mark Siegelman; Fiscal Year: 2000
    ..With these studies the proposal aims to determine new methods for intervening in the often detrimental effects of this kind of lymphocyte traffic. ..
  34. IDO: A Novel Endogenous Suppressor of Inflammation
    John Varga; Fiscal Year: 2002
    ..in vivo murine collagen-induced arthritis using a competitive IDO inhibitor modulated the course of experimental arthritis. The potential of IDO and TRP starvation to modulate both early and late steps in the synovial ..
  35. COLLAGEN PEPTIDES AND SUPPRESSION OF COLLAGEN ARTHRITIS
    Andrew Kang; Fiscal Year: 2001
    ..abstract_text> ..
  36. MOLECULAR ANALYSIS OF P/ANTIP
    Keith Elkon; Fiscal Year: 1999
    ..Characterization of the ternary complex would allow the dramatic advances in therapy of experimental autoimmune diseases (EAE, collagen arthritis) to be applied to SLE. ..
  37. SELF-DETERMINANTS & INDIRECTION OF ANTI-SELF IMMUNITY
    KAMAL MOUDGIL; Fiscal Year: 2001
    ..They believe that such predetermined, experimentally programmed control of the display hierarchy of cryptic self determinants would pave the way for novel immunotherapeutic strategies for prevention and treatment of cancer. ..
  38. Modulation of Autoimmunity by Green Tea Polyphenols
    KAMAL MOUDGIL; Fiscal Year: 2006
    ..The results of this study would help in establishing a reliable scientific basis for the use of PGT in autoimmune arthritis, and in developing better therapeutic approaches for RA. ..
  39. REGULATION OF AUTOIMMUNITY THROUGH EPITOPE SPREADING
    KAMAL MOUDGIL; Fiscal Year: 2006
    ..This in turn would contribute to developing novel therapeutic approaches for RA and other autoimmune diseases. [unreadable] [unreadable]..
  40. PROFILING SYNOVIAL VASCULATURE IN ARTHRITIS-PRONE RATS
    KAMAL MOUDGIL; Fiscal Year: 2005
    ..abstract_text> ..
  41. IKKi expression and regulation in rheumatoid arthritis
    Gary Firestein; Fiscal Year: 2005
    ..We propose to test the hypothesis that IKKi is an important signal transduction pathway that regulates inflammation in chronic arthritis and is a novel target for development of anti-rheumatic agents. ..
  42. SYNOVIAL DYSFUNCTION DUE TO P53 ABNORMALITIES IN RA
    Gary Firestein; Fiscal Year: 2006
    ..abstract_text> ..
  43. REGULATION OF PERIPHERAL INFLAMMATION BY THE CNS
    Gary Firestein; Fiscal Year: 2002
    ..These studies will provide a basis for understanding the central nervous system-immune system connection as well as explore novel therapeutic targets. ..
  44. Chemokine receptor antagonists in inflammatory disease
    Shiva Shahrara; Fiscal Year: 2007
    ..Achieving these goals may give us valuable information in regard to molecular inflammatory mechanisms involved in atherosclerosis and RA. ..
  45. Eicosanoid regulation of experimental Lyme arthritis
    Charles R Brown; Fiscal Year: 2010
    ..This information will further our understanding of how inflammation is regulated and allow the design of more effective anti-inflammatory treatments. ..
  46. MECHANISMS OF AUTOIMMUNE ARTHRITIS
    EDWARD ROSLONIEC; Fiscal Year: 2001
    ..These recombinant DR molecules will be tested for their ability to alter T-cell responses to hCII in vitro, and prevent the development of autoimmune arthritis in the DR transgenic mice. ..
  47. Innate immunity and experimental Lyme arthritis
    Charles Brown; Fiscal Year: 2007
    ..As such these studies; may have important implications not only for Lyme disease, but for other inflammatory diseases as well. ..
  48. Accelerated arthritis in E and P selectin deficient mice
    Jeffrey Ruth; Fiscal Year: 2007
    ..While common dogma suggests IL-1beta regulates selectins, this study proposes the novel hypothesis that in vivo E- and P-selectins regulate IL-1beta production and CIA development. [unreadable] [unreadable] [unreadable]..
  49. FRZB PROFILES AS OSTEOARTHRITIS BIOMARKERS
    MARY CORR; Fiscal Year: 2004
    ..The results of these studies will both contribute to, and will utilize, the resources of the OA biomarker consortium. ..
  50. Tyrosine Kinase Pathways in Autoimmune Arthritis.
    Ricardo Paniagua; Fiscal Year: 2008
    ....
  51. Investigation of Nod2: Implications for Uveitis
    Holly Rosenzweig; Fiscal Year: 2008
    ..Together, these studies will provide valuable new information on how Nod2 is involved in autoimmunity and the pathogeneis of uveitis. ..
  52. MYCOBACTERIUM TUBERCULOSIS;INDUCED MACROPHAGE SIGNALLING
    John Imboden; Fiscal Year: 2001
    ..The proposed experiments will enhance the understanding of the pathogenesis of tuberculosis, and will provide insight essential for developing effective approaches to enhancing the protective immune response to M. tuberculosis. ..
  53. Mechanism of Action of Inhibitory CpG Oligonucleotides
    Petar Lenert; Fiscal Year: 2009
    ..abstract_text> ..