Genomes and Genes
animal salmonella infections
Summary: Infections in animals with bacteria of the genus SALMONELLA.
Publications273 found, 100 shown here
- Analysis of cells targeted by Salmonella type III secretion in vivoKaoru Geddes
Department of Microbiology and Immunology, Oregon Health and Science University, Portland, Oregon, United States of America
PLoS Pathog 3:e196. 2007..These findings suggest that Salmonella specifically target splenic neutrophils presumably to attenuate their microbicidal functions, thereby promoting intracellular survival and replication in the mouse...
- Non-typhoidal Salmonella infections in pigs: a closer look at epidemiology, pathogenesis and controlF Boyen
Department of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium
Vet Microbiol 130:1-19. 2008....
- Antimicrobial actions of the NADPH phagocyte oxidase and inducible nitric oxide synthase in experimental salmonellosis. II. Effects on microbial proliferation and host survival in vivoP Mastroeni
Centre for Veterinary Science, University of Cambridge, Cambridge CB3 0ES, United Kingdom
J Exp Med 192:237-48. 2000..The NADPH phagocye oxidase and iNOS are both required for host resistance to wild-type Salmonella, but appear to operate principally at different stages of infection...
- Salmonella enterica serovar gallinarum requires ppGpp for internalization and survival in animal cellsJae Ho Jeong
Department of Microbiology, Chonnam National University Medical College, Gwangju 501 746, South Korea
J Bacteriol 190:6340-50. 2008..It was concluded that Salmonella serovar Gallinarum internalizes animal cells by a mechanism independent of SPI-1 genes but dependent on ppGpp. Intracellular growth also required ppGpp for the transcription of genes encoded in SPI-2...
- Phenotype of mice and macrophages deficient in both phagocyte oxidase and inducible nitric oxide synthaseM U Shiloh
Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York 10021, USA
Immunity 10:29-38. 1999..Their killing of S. typhimurium, E. coli, and attenuated Listeria was markedly diminished but demonstrable, establishing the existence of a mechanism of macrophage antibacterial activity independent of phox and NOS2...
- Dynamics of bacterial growth and distribution within the liver during Salmonella infectionMark Sheppard
Bacterial Infection Group, Centre for Veterinary Science, Department of Clinical Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 0ES, UK
Cell Microbiol 5:593-600. 2003..These findings suggest a novel mechanism underlying growth of salmonellae in vivo with important consequences for understanding mechanisms of resistance and immunity...
- Chicken cecum immune response to Salmonella enterica serovars of different levels of invasivenessAngela Berndt
Friedrich Loeffler Institute, Institute of Molecular Pathogenesis, Naumburger Str 96a, D 07743 Jena, Germany
Infect Immun 75:5993-6007. 2007..The data indicate that the capability of Salmonella serovars to enter the cecal mucosa and invade lower regions affects both the level and character of the immune response in tissue...
- Comparative genome analysis of Salmonella Enteritidis PT4 and Salmonella Gallinarum 287/91 provides insights into evolutionary and host adaptation pathwaysNicholas R Thomson
The Pathogen Sequencing Unit, The Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, United Kingdom
Genome Res 18:1624-37. 2008..Enteritidis-harboring mutations in functional homologs of the pseudogenes present in S. Gallinarum could provide an experimentally tractable route toward unraveling the genetic basis of host adaptation in S. enterica...
- Identification and functional characterization of chicken toll-like receptor 5 reveals a fundamental role in the biology of infection with Salmonella enterica serovar typhimuriumMuhammad Iqbal
Division of Immunology and Pathology, Institute for Animal Health, Compton, Newbury, Berkshire RG20 7NN, United Kingdom
Infect Immun 73:2344-50. 2005..Collectively, the data represent the identification and functional characterization of a nonmammalian TLR5 and indicate a role in restricting the entry of flagellated Salmonella into systemic sites of the chicken...
- The Ity/Lsh/Bcg locus: natural resistance to infection with intracellular parasites is abrogated by disruption of the Nramp1 geneS Vidal
Department of Biochemistry, McGill University, Montreal, Quebec, Canada
J Exp Med 182:655-66. 1995....
- Animal models of Salmonella infections: enteritis versus typhoid feverR L Santos
Department of Veterinary Pathobiology, College of Veterinary Medicine, Texas A and M University, College Station, TX 77843-4467, USA
Microbes Infect 3:1335-44. 2001..This article reviews murine typhoid and bovine enteritis and discusses strengths, limitations and distinctive features of these animal models...
- Salmonella typhimurium persists within macrophages in the mesenteric lymph nodes of chronically infected Nramp1+/+ mice and can be reactivated by IFNgamma neutralizationDenise M Monack
Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford University, Stanford, CA 94305, USA
J Exp Med 199:231-41. 2004..Thus, interferon-gamma, which may affect the level of macrophage activation, plays an essential role in the control of the persistent S. typhimurium infection in mice...
- Mechanisms of egg contamination by Salmonella EnteritidisInne Gantois
Department of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, Research Group Veterinary Public Health and Zoonoses, Ghent University, Merelbeke, Belgium
FEMS Microbiol Rev 33:718-38. 2009..This appears to require a unique combination of genes encoding for improved cell wall protection and repairing cellular and molecular damage, among others...
- The immunobiology of avian systemic salmonellosisLucy Chappell
Division of Immunology, Institute for Animal Health, Compton, Newbury, RG20 7NN, UK
Vet Immunol Immunopathol 128:53-9. 2009..In carrier animals persistence may lead to reproductive tract and egg infection associated with a decline in CD4+ T cell numbers and function associated with the onset of sexual maturity in hens...
- Mechanisms of quinolone resistance in Escherichia coli and Salmonella: recent developmentsKatie L Hopkins
Antimicrobial Resistance and Molecular Epidemiology Unit, Laboratory of Enteric Pathogens, Health Protection Agency Centre for Infections, 61 Colindale Avenue, London NW9 5HT, UK
Int J Antimicrob Agents 25:358-73. 2005....
- Age at primary infection with Salmonella enterica serovar Typhimurium in the chicken influences persistence of infection and subsequent immunity to re-challengeR K Beal
Division of Immunology and Immunopathology, Institute for Animal Health, Compton Laboratory, Compton, Newbury RG20 7NN, UK
Vet Immunol Immunopathol 100:151-64. 2004..This feature of the development of protective immunity needs to be considered when developing vaccines for the broiler sector of the poultry industry...
- Acidification of phagosomes containing Salmonella typhimurium in murine macrophagesM Rathman
Department of Microbiology and Immunology, Stanford University School of Medicine, California 94305, USA
Infect Immun 64:2765-73. 1996..Thus, we conclude that Salmonella-containing phagosomes acidify soon after formation and hypothesize that an acidic environment is necessary for survival and replication of the bacteria within the macrophage...
- IL-12 and IFN-gamma in host defense against mycobacteria and salmonella in mice and menE Jouanguy
Institut National de la Santé et de la Recherche Médicale Unité 429, Hopital Necker Enfants Malades, 149 rue de Sevres, 75015, Paris, France, EU
Curr Opin Immunol 11:346-51. 1999..The axis formed between IL-12 and IFN-gamma is essential for protective immunity against mycobacteria and salmonella in mice and men...
- Clearance of enteric Salmonella enterica serovar Typhimurium in chickens is independent of B-cell functionRichard K Beal
Division of Immunology, Institute for Animal Health, Compton, Newbury, Berkshire, United Kingdom
Infect Immun 74:1442-4. 2006..Infection induces high levels of specific antibody, but B cells do not play an essential role in clearance of primary infection or in the enhanced clearance after secondary challenge...
- Chicken gallinacin gene cluster associated with Salmonella response in advanced intercross lineJ R Hasenstein
Department of Animal Science, Iowa State University, Ames, IA 50010, USA
Avian Dis 51:561-7. 2007..The use of gallinacin single-nucleotide polymorphisms as molecular markers for genetic selection for Salmonella Enteritidis resistance might result in reduced bacterial burden via development of an enhanced innate immune response...
- Genetic regulation of host responses to Salmonella infection in miceM F Roy
Department of Human Genetics, McGill University Health Center, Montreal, Quebec, Canada
Genes Immun 3:381-93. 2002..In parallel, the relevant information pertaining to genes involved in resistance to Salmonella in humans will be discussed...
- Gene expression profiling in Salmonella Choleraesuis-infected porcine lung using a long oligonucleotide microarrayShu Hong Zhao
Department of Animal Science, Iowa State University, 2255 Kildee Hall, Ames, 50011, USA
Mamm Genome 17:777-89. 2006..These data represent the first thorough investigation of gene regulation pathways that control an important porcine respiratory and foodborne bacterial infection...
- 'Form variation' of the O12 antigen is critical for persistence of Salmonella Typhimurium in the murine intestineLydia M Bogomolnaya
Department of Microbial and Molecular Pathogenesis, College of Medicine, Texas A and M University System Health Science Center, College Station, TX 77843 1114, USA
Mol Microbiol 70:1105-19. 2008..Our data suggest that the 12-2 antigen is a S. enterica subspecies I-specific LPS modification that enhances long-term intestinal colonization, and is in contrast to the role of O-antigen variation described for Shigella...
- Isocitrate lyase (AceA) is required for Salmonella persistence but not for acute lethal infection in miceFerric C Fang
Department of Laboratory Medicine, University of Washington School of Medicine, Seattle, WA 98195 7242, USA
Infect Immun 73:2547-9. 2005..Substrate availability in the phagosome appears to evolve over time, with increasing fatty acid dependence during chronic infection...
- Virulence potential of five major pathogenicity islands (SPI-1 to SPI-5) of Salmonella enterica serovar Enteritidis for chickensIvan Rychlik
Veterinary Research Institute, Hudcova 70, 621 00 Brno, Czech Republic
BMC Microbiol 9:268. 2009..e. with the remaining four deleted) and a mutant with all 5 SPIs deleted, and assessed their virulence in one-day-old chickens, together with the innate immune response of this host...
- Slc11a1-mediated resistance to Salmonella enterica serovar Typhimurium and Leishmania donovani infections does not require functional inducible nitric oxide synthase or phagocyte oxidase activityJacqueline K White
Wellcome Trust MRC Building, University of Cambridge School of Clinical Medicine, Addenbrookes Hospital, Hills Road, Cambridge CB2 2XY, UK
J Leukoc Biol 77:311-20. 2005..This highlights the adaptive differences in tissue and cellular tropisms between L. donovani and L. major and the different genes and mechanisms that regulate visceral versus cutaneous forms of the disease...
- Role of neutrophils in murine salmonellosisCedric Cheminay
Institut fur Klinische Mikrobiologie, Immunologie und Hygiene, FAU Erlangen Nürnberg, D 91054 Erlangen, Germany
Infect Immun 72:468-77. 2004..In the latter conditions, rapid neutrophil attraction efficiently prevents the spread of the pathogen, whereas the neutrophil influx is delayed during systemic infections and cannot protect against lethal bacteremia...
- Intracellular demography and the dynamics of Salmonella enterica infectionsSam P Brown
Department of Zoology, University of Cambridge, Cambridge, United Kingdom
PLoS Biol 4:e349. 2006....
- Salmonella infections: immune and non-immune protection with vaccinesP A Barrow
School of Veterinary Medicine and Science, University of Nottingham Loughborough, Sutton Bonington, LE12 5RD, UK
Avian Pathol 36:1-13. 2007..There are additional areas of concern associated with the use of live vaccines, particularly if these are generated by genetic manipulation...
- Characterization of Salmonella enterica serovar typhimurium DT104 isolated from Denmark and comparison with isolates from Europe and the United StatesD L Baggesen
Danish Veterinary Laboratory, DK 1790 Copenhagen V, Denmark
J Clin Microbiol 38:1581-6. 2000..Thus, a more sensitive technique for subtyping of strains of DT104 and a broader investigation may help in elucidating the epidemiological spread of DT104 in different parts of the world...
- Comparative analysis of Salmonella enterica serovar Enteritidis mutants with a vaccine potentialD Karasova
Veterinary Research Institute, Hudcova 70, 621 00 Brno, Czech Republic
Vaccine 27:5265-70. 2009..Furthermore, when a detailed comparison of polymyxin and serum sensitive mutants was performed, the serum sensitive mutants were more immunogenic...
- QTL for resistance to Salmonella carrier state confirmed in both experimental and commercial chicken linesF Calenge
INRA, Unité de Recherches Avicoles, 37380 Nouzilly, France
Anim Genet 40:590-7. 2009..Genetic studies conducted on experimental lines can therefore be of potential interest for marker-assisted selection in commercial lines...
- Characterization of the expression of Salmonella Type III secretion system factor PrgI, SipA, SipB, SopE2, SpaO, and SptP in cultures and in miceHao Gong
Division of Infectious Diseases, School of Public Health, University of California, Berkeley, CA 94720, USA
BMC Microbiol 9:73. 2009..However, the expression of these proteins has not been extensively studied in vivo, especially during the later stages of salmonellosis when the infection is established...
- Targeting QseC signaling and virulence for antibiotic developmentDavid A Rasko
Department of Microbiology, University of Texas UT Southwestern Medical Center, Dallas, TX 75390, USA
Science 321:1078-80. 2008..Inhibition of signaling offers a strategy for the development of broad-spectrum antimicrobial drugs...
- Use of pulsed-field gel electrophoresis of conserved XbaI fragments for identification of swine Salmonella serotypesStephen B Gaul
Department of Animal Science, Iowa State University, 11 Kildee Hall, Ames, IA 50011, USA
J Clin Microbiol 45:472-6. 2007..PFGE using XbaI restriction provided a possible alternative method for screening and identifying swine Salmonella serotypes...
- Prevalence of Salmonella spp. in pet reptiles in JapanAya Nakadai
Division of Animal Life Science, Institute of Symbiotic Science and Technology, Tokyo University of Agriculture and Technology, Saiwai cho, Fuchu, Tokyo, Japan
J Vet Med Sci 67:97-101. 2005..The predominant serovars were found to be S. Bardo, S. Newport and S. Panama, which cause human salmonellosis. These results indicate that pet reptiles may be a potential infectious source of human salmonellosis in Japan...
- Norepinephrine augments Salmonella enterica-induced enteritis in a manner associated with increased net replication but independent of the putative adrenergic sensor kinases QseC and QseEGillian D Pullinger
Division of Microbiology, Institute for Animal Health, Compton, Berkshire, RG20 7NN, United Kingdom
Infect Immun 78:372-80. 2010....
- Autophagy recognizes intracellular Salmonella enterica serovar Typhimurium in damaged vacuolesCheryl L Birmingham
Infection, Immunity, Injury and Repair Program, The Hospital for Sick Children, Toronto, Ontario, Canada
Autophagy 2:156-8. 2006..Results of our in vitro infection studies are consistent with autophagy playing a role in cellular defense against S. Typhimurium that become exposed to the cytosol...
- The chicken, the egg and Salmonella enteritidisJ Guard-Petter
US Department of Agriculture, Agricultural Research Service, 934 College Station Road, Athens, GA 30605, USA
Environ Microbiol 3:421-30. 2001..This review highlights the stages of transmission and discusses evidence that altered bacterial growth patterns and specific cell surface characteristics contribute to the adaptation of S. enteritidis to these diverse environments...
- SseK1 and SseK2 are novel translocated proteins of Salmonella enterica serovar typhimuriumSonya L Kujat Choy
Biotechnology Laboratory, University of British Columbia, Room 237, Wesbrook Building, 6174 University Blvd, Vancouver, BC, Canada V6T 1Z3
Infect Immun 72:5115-25. 2004..In summary, this work demonstrates that SseK1 and SseK2 are novel translocated proteins of serovar Typhimurium...
- SipA, SopA, SopB, SopD and SopE2 effector proteins of Salmonella enterica serovar Typhimurium are synthesized at late stages of infection in miceM N Giacomodonato
Centro de Estudios Farmacológicos y Botánicos CEFYBO CONICET, Universidad de Buenos Aires, Facultad de Medicina, Departamento de Microbiologia, Parasitología e Immunología, Buenos Aires, Argentina
Microbiology 153:1221-8. 2007..Together, these results indicate that SPI-1 effector proteins may participate in the late stages of Salmonella infection in mice...
- Induction of a novel chicken Toll-like receptor following Salmonella enterica serovar Typhimurium infectionRowan Higgs
Education and Research Centre, St Vincent s University Hospital, Elm Park, Dublin 4, Ireland
Infect Immun 74:1692-8. 2006..We hypothesize that TLR15 may represent an avian-specific TLR that has been either retained in chicken and lost in other taxa or gained in the chicken...
- Global transcriptional response of porcine mesenteric lymph nodes to Salmonella enterica serovar TyphimuriumYanfang Wang
Department of Animal Science and Center for Integrated Animal Genomics Iowa State University, Ames, IA 50010, USA
Genomics 90:72-84. 2007..We propose that such NFkappaB suppression in antigen-presenting cells may be the mechanism by which S. Typhimurium eludes a strong inflammatory response to establish a carrier status in pigs...
- Pathogenesis of enteric Salmonella infectionsGuntram A Grassl
Michael Smith Laboratories, Canada
Curr Opin Gastroenterol 24:22-6. 2008..The use of various animal models has greatly advanced understanding of Salmonella pathogenesis at intestinal and systemic sites. This review will emphasize recent advances in the understanding of intestinal Salmonella infections...
- Fecal shedding of Salmonella spp. by dairy cows on farm and at cull cow marketsS J Wells
Department of Clinical and Population Sciences, College of Veterinary Medicine, University of Minnesota, St Paul 55108, USA
J Food Prot 64:3-11. 2001..This study provides information describing the distribution of Salmonella fecal shedding from dairy cows on farm and at markets and will serve as a baseline for future studies...
- Colonization of specific regions of the reproductive tract and deposition at different locations inside eggs laid by hens infected with Salmonella enteritidis or Salmonella heidelbergRichard K Gast
United States Department of Agriculture, Agricultural Research Service, Egg Safety and Quality Research Unit, Russell Research Center, 950 College Station Road, Athens, GA 30605, USA
Avian Dis 51:40-4. 2007....
- Multilocus sequence typing lacks the discriminatory ability of pulsed-field gel electrophoresis for typing Salmonella enterica serovar TyphimuriumMohamed K Fakhr
Department of Veterinary and Microbiological Sciences, North Dakota State University, Fargo, ND 58105, USA
J Clin Microbiol 43:2215-9. 2005..enterica serovar Typhimurium LT2 strain. Therefore, MLST, using these genes, lacks the discriminatory power of PFGE for typing Salmonella enterica serovar Typhimurium...
- Effect of metC mutation on Salmonella Gallinarum virulence and invasiveness in 1-day-old White Leghorn chickensDevendra H Shah
Bio Safety Research Institute, College of Veterinary Medicine, Chonbuk National University, Jeonju, Jeonbuk 561 756, South Korea
Vet Microbiol 119:352-7. 2007..01) bacterial burden in the reticuloendothelial organs when compared with the wild-type parent. These results indicate that metC gene is important for virulence of S. Gallinarum in chickens...
- QseC mediates Salmonella enterica serovar typhimurium virulence in vitro and in vivoCristiano G Moreira
University of Texas Southwestern Medical Center, Department of Microbiology, Dallas, TX 75390 9048, USA
Infect Immun 78:914-26. 2010..Elucidation of the role of this interkingdom signaling system in Salmonella serovar Typhimurium should contribute to a better understanding of the complex interplay between the pathogen and the host during infection...
- Absence of all components of the flagellar export and synthesis machinery differentially alters virulence of Salmonella enterica serovar Typhimurium in models of typhoid fever, survival in macrophages, tissue culture invasiveness, and calf enterocolitisC K Schmitt
Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, F. Edward Hebert School of Medicine, Bethesda, Maryland 20814, USA
Infect Immun 69:5619-25. 2001....
- Localization to chicken chromosome 5 of a novel locus determining salmonellosis resistanceP Mariani
Department of Veterinary Pathobiology, Universityof Minnesota, St Paul, 55108, USA
Immunogenetics 53:786-91. 2001..The homologous human and mouse regions at present contain no likely candidate genes for this trait. Thus this appears to be a novel resistance gene, which we designate SAL1...
- A limited role for SsrA/B in persistent Salmonella Typhimurium infections in pigsFilip Boyen
Department of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B 9820 Merelbeke, Belgium
Vet Microbiol 128:364-73. 2008..These results suggest that the ssrA/B gene of Salmonella Typhimurium plays a limited role in the persistent intestinal colonization of pigs...
- Early epithelial invasion by Salmonella enterica serovar Typhimurium DT104 in the swine ileumD K Meyerholz
Department of Veterinary Microbiology, Iowa State University, Ames, USA
Vet Pathol 39:712-20. 2002..Furthermore, the combination of SEM and TEM data suggests that Salmonella serovar Typhimurium may use sites of cell extrusion as an additional mechanism for early invasion...
- Risk factors for clinical salmonellosis in Virginia, USA cattle herdsL D Warnick
Virginia Maryland Regional College of Veterinary Medicine, Blacksburg, VA, USA
Prev Vet Med 49:259-75. 2001..01, 0.98), poultry manure spread on bordering property (OR=4.00; CI 1.00, 26.50), signs of rodents in cattle-housing or feed-storage areas (OR=2.75; CI 0.94, 9.92), and contact of wild geese with cattle or feed (OR=4.5; 1.16, 29.51)...
- The spv genes on the Salmonella dublin virulence plasmid are required for severe enteritis and systemic infection in the natural hostS J Libby
Department of Medicine, University of California, San Diego, La Jolla 92093 0640, USA
Infect Immun 65:1786-92. 1997..These results suggest that the spv genes of S. dublin promote enhanced intracellular proliferation in intestinal tissues and at extraintestinal sites in the natural host...
- Salmonella enterica isolates from faeces of domestic reptiles and a study of their antimicrobial in vitro sensitivityV V Ebani
Department of Animal Pathology, Prophylaxis and Food Hygiene, University of Pisa, Viale delle Piagge 2, 56124 Pisa, Italy
Res Vet Sci 78:117-21. 2005..51%) and ampicillin (27.40%). All but one of the isolates were sensitive to chloramphenicol. A high percentages of isolates were sensitive to enrofloxacin (84.93%), nitrofurantoin (80.82%), trimethoprim (76.71%) and tetracycline (75.34%)...
- Salmonella enterica serovar Choleraesuis infection of the porcine jejunal Peyer's patch rapidly induces IL-1beta and IL-8 expressionKendra A Hyland
Department of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, 1971 Commonwealth Avenue, St Paul, MN 55108, USA
Vet Immunol Immunopathol 109:1-11. 2006....
- Toward standardization of diagnostic PCR testing of fecal samples: lessons from the detection of salmonellae in pigsB Malorny
Federal Institute for Risk Assessment BfR, D 12277 Berlin, Germany
J Clin Microbiol 43:3033-7. 2005
- Salmonella typhimurium infections in mice deficient in interleukin-4 production: role of IL-4 in infection-associated pathologyP Everest
Department of Biochemistry, Imperial College of Science Technology, and Medicine, London, United Kingdom
J Immunol 159:1820-7. 1997..The immune response in both IL-4(-/-) and IL-4(+/+) mice was of the Th1-type. Viable salmonella bacteria could be found associated with abscesses. Both IL-4(-/-) and IL-4(+/+) mice were resistant to killing by S. typhimurium aroA...
- RosE represses Std fimbrial expression in Salmonella enterica serotype TyphimuriumDaniela Chessa
Department of Medical Microbiology and Immunology, School of Medicine, University of California at Davis, One Shields Ave, Davis, CA 95616 8645, USA
Mol Microbiol 68:573-87. 2008..These data suggest that a tight control of Std fimbrial expression mediated by RosE is required during host pathogen interaction...
- Solitary intestinal lymphoid tissue provides a productive port of entry for Salmonella enterica serovar TyphimuriumStephan Halle
Institute of Immunology, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
Infect Immun 75:1577-85. 2007..In conclusion, SILT, a lymphoid compartment mostly neglected in earlier studies, represents a major site for Salmonella invasion and ensuing mucosal pathology...
- Relative distribution and conservation of genes encoding aminoglycoside-modifying enzymes in Salmonella enterica serotype typhimurium phage type DT104T S Frana
Department of Veterinary Microbiology and Preventive Medicine, Iowa State University College of Veterinary Medicine, Ames, Iowa 50011, USA
Appl Environ Microbiol 67:445-8. 2001..The data from this study indicate that pentaresistant DT104 does not acquire extra-integron genes in species- or geography-related foci, which supports the hypothesis that clonal expansion is the method of spread of this organism...
- A probabilistic transmission model of Salmonella in the primary broiler production chainJukka Ranta
Department of Risk Assessment, National Veterinary and Food Research Institute, Helsinki, Finland
Risk Anal 22:47-58. 2002..3%-17.4%] (no intervention), and [0.9%-5.8%] (with intervention). In the scenario of one infected grandparent flock, these were [2.8%-43.1%] and [1.0%-5.9%], respectively. Computations were performed using WinBUGS and Matlab softwares...
- Net replication of Salmonella enterica serovars Typhimurium and Choleraesuis in porcine intestinal mucosa and nodes is associated with their differential virulenceSusan M Paulin
Enteric Bacterial Pathogens Laboratory, Division of Microbiology, Institute for Animal Health, Compton, Berkshire, United Kingdom
Infect Immun 75:3950-60. 2007....
- Salmonella enterica in reptiles of German and Austrian originL Geue
Bundesforschungsanstalt fur Viruskrankheiten der Tiere, Institut für epidemiologische Diagnostik, Seestr 55, D 16868 Wusterhausen, Germany
Vet Microbiol 84:79-91. 2002..8% in samples from wild-caught animals. The high percentage of Salmonella in reptiles in our study confirms the risk for the transmission of the infection to humans...
- Effect of type 1 fimbriae of Salmonella enterica serotype Enteritidis on bacteraemia and reproductive tract infection in laying hensJeroen De Buck
Department of Pathology, Bacteriology and Poultry Diseases, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium
Avian Pathol 33:314-20. 2004..Thus, the absence of type 1 fimbriae prolongs bacteraemia, modifies reproductive tract infection and reduces egg shell contamination by Salmonella enterica serovar Enteritidis...
- Sublethal infection of C57BL/6 mice with Salmonella enterica Serovar Typhimurium leads to an increase in levels of Toll-like receptor 1 (TLR1), TLR2, and TLR9 mRNA as well as a decrease in levels of TLR6 mRNA in infected organsSabine Tötemeyer
Centre for Veterinary Science, Department of Clinical Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 0ES, United Kingdom
Infect Immun 73:1873-8. 2005..enterica serovar Typhimurium infection. During infection, the Toll-lie receptor 1 (TLR1), TLR2, and TLR9 mRNA levels increased, while TLR6 mRNA expression decreased...
- Salmonella typhimurium aroA- infection in gene-targeted immunodeficient mice: major role of CD4+ TCR-alpha beta cells and IFN-gamma in bacterial clearance independent of intracellular locationJ Hess
Department of Immunology, University of Ulm, Germany
J Immunol 156:3321-6. 1996..typhimurium SL7207 Hlys and control strains did not differ in beta 2m-/- mutants. This finding argues against direct correlation of cytosolic location of S. typhimurium SL7207 Hlys with CD8+ T cell dependency of protection...
- Epidemiological analysis of Salmonella enterica ssp. enterica serovars Hadar, Brancaster and Enteritidis from humans and broiler chickens in Senegal using pulsed-field gel electrophoresis and antibiotic susceptibilityE Cardinale
Programme Productions Animales, CIRAD EMVT, Montpellier Cedex, France
J Appl Microbiol 99:968-77. 2005..Our objective was to analyse the pulsed-field gel electrophoresis (PFGE) and antibioresistance patterns of strains belonging to these serovars and to assess the significance of broiler-chicken meat as a source of human infection...
- Cell-mediated and humoral immune responses to a virulent plasmid-cured mutant strain of Salmonella enterica serotype gallinarum in broiler chickensNeeraj Rana
Department of Veterinary Public Health and Epidemiology, CCS Haryana Agricultural University, Hisar 125 004, Haryana, India
Vet Microbiol 115:156-62. 2006..These findings indicate that the live attenuated mutant vaccine induced a strong cellular and humoral immunity, which may play a role in the protection of fowl typhoid in broiler chickens...
- The genetics of Salmonella genomic island 1Michael R Mulvey
National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Canada
Microbes Infect 8:1915-22. 2006..Drug-resistant variants of SGI1 have been identified in numerous serotypes. Strains harboring SGI1 may be more virulent and have a tendency to rapidly disseminate...
- Occurrence and characterization of resistance to extended-spectrum cephalosporins mediated by beta-lactamase CMY-2 in Salmonella isolated from food-producing animals in CanadaKevin J Allen
OIE Reference Laboratory for Salmonellosis, Laboratory for Foodborne Zoonoses, Population and Public Health Branch, Health Canada, Guelph, Ontario
Can J Vet Res 66:137-44. 2002..Pulsed-field gel electrophoresis and plasmid profiles indicated that both clonal dispersion and horizontal transfer of blaCMY-2 may have caused dissemination of the resistance determinant...
- Mucosal innate immune response to intragastric infection by Salmonella enterica serovar CholeraesuisKendra A Hyland
Department of Microbiology, University of Minnesota, 1460 Mayo Memorial Building, 420 Delaware Street, S E, Minneapolis, MN 55455, USA
Mol Immunol 43:1890-9. 2006..These data indicate that IL-1beta and IL-8 expression in the IPP plays a key role early in the interaction between Salmonella serovar Choleraesuis and the small intestine...
- Identification of genetic loci controlling bacterial clearance in experimental Salmonella enteritidis infection: an unexpected role of Nramp1 (Slc11a1) in the persistence of infection in miceJ Caron
Department of Human Genetics, McGill University, Montreal, Canada
Genes Immun 3:196-204. 2002..These mice have a significantly lower spleen bacterial load compared to the wild-type 129sv mice, strongly suggesting the involvement of Nramp1 in controlling S. enteritidis clearance during the late phase of infection...
- Differential mRNA expression of the avian-specific toll-like receptor 15 between heterophils from Salmonella-susceptible and -resistant chickensJessica R Nerren
USDA ARS, Southern Plains Agricultural Research Center, 2881 F and B Road, College Station, TX 77845, USA
Immunogenetics 61:71-7. 2009..These data indicate that differences in the gene expression of TLR 15 by heterophils likely accounts for some of the observed differences between the lines in their susceptibility to infection...
- Comparison of intestinal invasion and macrophage response of Salmonella Gallinarum and other host-adapted Salmonella enterica serovars in the avian hostMark S Chadfield
Department of Veterinary Microbiology, The Royal Veterinary and Agricultural University, Stigbøjlen 4, 1870 Frederiksberg C, Denmark
Vet Microbiol 92:49-64. 2003..Gallinarum host specificity in the chicken correlates with systemic infection, intestinal and lymphoid tissue invasion in the bursa and caeca, and macrophage survival does not influence this outcome...
- CD4+-T-cell responses generated during murine Salmonella enterica serovar Typhimurium infection are directed towards multiple epitopes within the natural antigen FliCMolly A Bergman
Department of Microbiology, University of Washington Medical Center, Box 357110, 1959 NE Pacific Street, Seattle, WA 98195, USA
Infect Immun 73:7226-35. 2005..Together, these data suggest that FliC-specific CD4+ T cells may contribute to cell-mediated host defenses against Salmonella...
- Epidemiologic and pathologic aspects of Salmonella typhimurium infection in passerine birds in NorwayThorbjørn Refsum
Section of Bacteriology, National Veterinary Institute, P O Box 8156, Dep, N 0033 Oslo, Norway
J Wildl Dis 39:64-72. 2003..Typhimurium 4, 12: i:1, 2 in their intestines. The carrier species largely reflected the species most often suffering from fatal infection...
- Rapid protection of gnotobiotic pigs against experimental salmonellosis following induction of polymorphonuclear leukocytes by avirulent Salmonella entericaN Foster
Division of Environmental Microbiology, Institute for Animal Health, Compton Laboratory, Compton, Newbury, Berkshire RG20 7NN, United Kingdom
Infect Immun 71:2182-91. 2003..They also demonstrate that PMN induction is not necessarily associated with clinical symptoms and/or intestinal pathology...
- Age-stratified validation of an indirect Salmonella Dublin serum enzyme-linked immunosorbent assay for individual diagnosis in cattleLiza Rosenbaum Nielsen
Department of Animal Science and Animal Health, The Royal Veterinary and Agricultural University, 1870 Frederiksberg C, Denmark
J Vet Diagn Invest 16:212-8. 2004..Purpose-related test sensitivities and specificities were evaluated at different cutoff values...
- Testing of bulk tank milk for Salmonella Dublin infection in Danish dairy herdsA Wedderkopp
Cattle Health Laboratory, Danish Dairy Board, Brørup
Can J Vet Res 65:15-21. 2001..It was concluded that the investigated ELISA method was in general accordance with the cases of clinical S. Dublin infection recorded, and that the method has a potential for national screening purposes...
- Salmonella serovar specific upregulation of porcine defensins 1 and 2 in a jejunal epithelial cell lineEdwin J A Veldhuizen
Department of Infectious Diseases and Immunology, Utrecht University, Utrecht, The Netherlands
Vet Microbiol 136:69-75. 2009..These results provide further insight into the porcine innate immune response towards Salmonella infections, and could partially explain the different epidemiology of Salmonella infections in pig...
- Sero types, phage types and antibiotic susceptibilities of Salmonella strains isolated from horses in The Netherlands from 1993 to 2000E van Duijkeren
Department of Infectious Diseases and Immunology, Bacteriology Division, Faculty of Veterinary Medicine, Utrecht University, P O Box 80165, 3508 TD Utrecht, The Netherlands
Vet Microbiol 86:203-12. 2002..The most common S. Typhimurium phage types in horses corresponded with those found in humans, pigs and cattle in the same period in The Netherlands...
- SseL is a salmonella-specific translocated effector integrated into the SsrB-controlled salmonella pathogenicity island 2 type III secretion systemBrian K Coombes
Department of Biochemistry and Biomedical Sciences, McMaster University, Health Sciences Centre, Room 4H17, 1200 Main St West, Hamilton, Ontario L8N 3Z5, Canada
Infect Immun 75:574-80. 2007..Animal infection experiments with sseL mutant bacteria indicate that integration of SseL into the SsrB response regulatory system contributes to systemic virulence of this pathogen...
- Virulence attenuation and live vaccine potential of aroA, crp cdt cya, and plasmid-cured mutants of Salmonella enterica serovar Abortusovis in mice and sheepSergio Uzzau
Dipartimento di Scienze Biomediche, Center for Biotechnology Development and Biodiversity Research, Universita di Sassari, Italy
Infect Immun 73:4302-8. 2005..All three vaccine candidates appear to be safe for use in sheep and provide a model for the development of live vaccine candidates against naturally occurring ovine salmonellosis...
- Molecular characterization of multiresistant d-tartrate-positive Salmonella enterica serovar paratyphi B isolatesAngelika Miko
National Salmonella Reference Laboratory, Federal Institute for Health Protection of Consumers and Veterinary Medicine, 12277 Berlin, Germany
J Clin Microbiol 40:3184-91. 2002..Today, a particular clone predominates in some German poultry production lines, poultry products, and various other sources. It was also detected in contemporary isolates from two neighboring countries as well...
- A rat model of infection by Salmonella typhimurium or Salm. enteritidisP J Naughton
Division of Nutritional Sciences, Rowett Research Institute, Bucksburn, Aberdeen, UK
J Appl Bacteriol 81:651-6. 1996..The rat model may therefore provide a means to test in vivo interventionist strategies, designed to block binding of the pathogens in the gastrointestinal tract...
- Microsatellites linked to Salmonella enterica Serovar Enteritidis burden in spleen and cecal content of young F1 broiler-cross chicksM G Kaiser
Department of Animal Science, Iowa State University, Ames 50011 3150, USA
Poult Sci 81:657-63. 2002..All four microsatellites had a significant (P < or = 0.05) main effect or interaction with dam line or sex on the level of SE in spleen and cecal contents...
- Molecular and phenotypic analysis of the CS54 island of Salmonella enterica serotype typhimurium: identification of intestinal colonization and persistence determinantsRobert A Kingsley
Department of Medical Microbiology and Immunology, College of Medicine, Texas A and M University System Health Science Center, College Station 77843 1114, USA
Infect Immun 71:629-40. 2003..These data suggest that colonization of the murine cecum is required for efficient fecal shedding in mice...
- Salmonella typhimurium disseminates within its host by manipulating the motility of infected cellsMicah J Worley
Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
Proc Natl Acad Sci U S A 103:17915-20. 2006..This is a previously uncharacterized mechanism by which an intracellular pathogen overcomes host defenses designed to immobilize infected cells...
- Homocysteine antagonism of nitric oxide-related cytostasis in Salmonella typhimuriumM A De Groote
Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
Science 272:414-7. 1996..Homocysteine may act as an endogenous NO antagonist in diverse processes including infection, atherosclerosis, and neurologic disease...
- Analysis of the contribution of Salmonella pathogenicity islands 1 and 2 to enteric disease progression using a novel bovine ileal loop model and a murine model of infectious enterocolitisBrian K Coombes
Michael Smith Laboratories, 301 2185 East Mall, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada
Infect Immun 73:7161-9. 2005..These data delineate novel phenotypes for SPI-1 and SPI-2 mutants in the intestinal phase of bovine and murine salmonellosis and provide working models to further investigate the effector contribution to these pathologies...
- Salmonella enterica serotype Enteritidis and eggs: a national epidemic in the United StatesChristopher R Braden
Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
Clin Infect Dis 43:512-7. 2006..Since 1996, the incidence of SE infection in humans has decreased greatly, although many cases and outbreaks due to SE contaminated eggs continue to occur...
- Intracellular Salmonella inhibit antigen presentation by dendritic cellsCedric Cheminay
Institut fur Klinische Mikrobiologie, Immunologie und Hygiene, Friedrich Alexander Universitat Erlangen Nurnberg, Erlangen, Germany
J Immunol 174:2892-9. 2005..The subversion of DC functions is a novel strategy deployed by this pathogen to escape immune defense, colonize host organs, and persist in the infected host...
- Identification of a Salmonella virulence gene required for formation of filamentous structures containing lysosomal membrane glycoproteins within epithelial cellsM A Stein
Biotechnology Laboratory, University of British Columbia, Vancouver, Canada
Mol Microbiol 20:151-64. 1996..Collectively, these results suggest that sifA arose by horizontal gene transfer into Salmonella and its product is involved in a virulence-associated intracellular phenotype related to Salmonella-induced filament formation...
- Genes encoding putative effector proteins of the type III secretion system of Salmonella pathogenicity island 2 are required for bacterial virulence and proliferation in macrophagesM Hensel
Lehrstuhl für Bakteriologie, Max von Pettenkofer Institut fur Hygiene und Medizinische Mikrobiologie, Munich, Germany
Mol Microbiol 30:163-74. 1998..These data suggest that, in vivo, one of the functions of the SPI-2 secretion system is to enable intracellular bacterial proliferation...
- Macrophage-dependent induction of the Salmonella pathogenicity island 2 type III secretion system and its role in intracellular survivalD M Cirillo
Department of Microbiology and Immunology, Stanford University School of Medicine, CA 94305, USA
Mol Microbiol 30:175-88. 1998..We conclude that SPI-2 genes are specifically expressed upon entry into mammalian cells and are required for intracellular growth in host cells in vivo and in vitro...
- Membrane vesicles are immunogenic facsimiles of Salmonella typhimurium that potently activate dendritic cells, prime B and T cell responses, and stimulate protective immunity in vivoRobert C Alaniz
Department of Laboratory Medicine, University of Washington, Seattle, WA 98195, USA
J Immunol 179:7692-701. 2007..Our findings also reveal MVs are a functional nonviable complex vaccine for Salmonella by their ability to prime protective B and T cell responses in vivo...
- Genome-wide screen for Salmonella genes required for long-term systemic infection of the mouseTrevor D Lawley
Department of Microbiology and Immunology, Stanford University, Stanford, California, USA
PLoS Pathog 2:e11. 2006....
- Contribution of target gene mutations and efflux to decreased susceptibility of Salmonella enterica serovar typhimurium to fluoroquinolones and other antimicrobialsSheng Chen
Department of Nutrition and Food Science, 0112 Skinner Building, University of Maryland, College Park, MD 20742, USA
Antimicrob Agents Chemother 51:535-42. 2007....
- The Salmonella pathogenicity island-1 type III secretion systemC P Lostroh
Department of Microbiology and Molecular Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, Massachusetts 02115, USA
Microbes Infect 3:1281-91. 2001..The expression of SPI1 genes is controlled by many global regulatory pathways that affect the expression/activity of transcriptional regulators encoded on SPI1...
- Helicobacter Host Interactions in Animal ModelsStanley Falkow; Fiscal Year: 2009....
- 37th Annual Meeting of the Society for Leukocyte BiologyJoshua Fierer; Fiscal Year: 2004..We encourage students and other trainees to submit abstracts; the SLB gives awards for the best abstracts submitted by students. One of the main purposes of the meeting is to encourage young scientists. ..
- GENETIC AND MOLECULAR BASIS OF BACTERIAL INVASIONStanley Falkow; Fiscal Year: 2007..unreadable] [unreadable]..
- Innate Immunity to Salmonella InfectionsJoshua Fierer; Fiscal Year: 2005..We will compare isogenic strains of salmonella that express either the group B or 0 LPS antigens in C3 deficient and neutropenic mice, in order to determine how the structure of the LPS affects virulence in mice. ..
- MUCOSAL DEFENSE MECHANISMS IN SUBSTANCE ABUSEDavid R Brown; Fiscal Year: 2010....
- Interaction of Yersinia with dendritic cellsIgor Brodsky; Fiscal Year: 2007..This knowledge will be important in the development of future strategies against human pathogens. ..
- Flow Cytometry Core Center BD FACSAriaMark Soloski; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- Analysis of CD81-PGRL complex on T cellsSTEPHEN CHAPES; Fiscal Year: 2007..The coordinated effect of CD81, PGRL and EP3 on T cell integrin activity measured by adhesion to or motility on ICAMs. ..
- T Cell Initiated Gastric PathologyROBINNA LORENZ; Fiscal Year: 2007..1 Description, ..
- Innate Cellular Elements and Enteric Bacterial InfectionMark Soloski; Fiscal Year: 2006..Given that many of the cellular receptors in the mouse model have human counterparts, we argue that this murine model will yield valuable information that may be applied to the human setting. ..
- DNA DAMAGE AND REPAIR IN SALMONELLA PATHOGENESISFerric Fang; Fiscal Year: 2007..unreadable] [unreadable]..
- Mucosal Lymphocyte Homing in the Head and NeckDavid Pascual; Fiscal Year: 2008..n. challenge with CT. From this work, we will learn how routes of immunizations can be used to effectively target vaccines to nonintestinal mucosal sites. ..
- Genetics of Programmed Cell Death in ArabidoposisJeffery L Dangl; Fiscal Year: 2010..This is the first definition of a function for these proteins, and allows us to propose a detailed characterization of their action as positive cell death regulators. ..
- Iron Homeostasis in Salmonella-Host InteractionsFerric C Fang; Fiscal Year: 2010..This work will have fundamental implications for understanding the strategies by which pathogenic microbes evade innate immunity by minimizing iron- dependent cell damage and maintaining iron homeostasis. ..
- Mucosal Therapy for AutoimmunityDavid Pascual; Fiscal Year: 2008..Studies in Specific Aim 3 will determine the responsible dendritic cell subset that supports regulatory T cell development. ..
- Pandemic influenza control at the borders of island countries and in householdMichael Baker; Fiscal Year: 2008..Findings from the housing cohort would be used to guide advice about reducing influenza transmission in households, particularly in terms of crowding levels and exposure to active and passive smoking. ..
- T CELL RESPONSES TO INTRACELLULAR BACTERIAL PATHOGENSMark Soloski; Fiscal Year: 2008..Given that many of the cellular receptors in the mouse model have human counterparts, we argue that this murine model will yield valuable information that may be applied to the human setting. ..
- Regulation Paneth cell defensins by bacterial infectionNita Salzman; Fiscal Year: 2009....
- Corticotropin Releasing Factor-Norepinephrine Interactions in Stress & DepressionADRIAN DUNN; Fiscal Year: 2008..The results should establish a model and indicate the nature of the cerebral structures involved, so that we can subsequently test the feed-forward hypothesis [unreadable] [unreadable]..
- Repair of methionine residues in H. pylori catalaseRobert Maier; Fiscal Year: 2008..It is proposed to understand what factors influence the need for this repair in a key protein. [unreadable] [unreadable] [unreadable] [unreadable]..
- Mammalian metal transporters & Salmonella infectionBOBBY CHERAYIL; Fiscal Year: 2006..These studies will identify new aspects of the Salmonella-host cell interaction, shed light on the role of mammalian metal transporters in Salmonella infection, and suggest novel approaches to treating salmonellosis. ..
- OPIOIDS, OPIOID RECEPTORS, AND SEPSISTOBY EISENSTEIN; Fiscal Year: 2001..It relates to events associated with both the therapeutic and non-therapeutic use of morphine and other opioid drugs. ..
- MUCOSAL TRANSGENE VACCINATION FOR HIVDavid Pascual; Fiscal Year: 2003..These studies will provide the basis for future development of subunit vaccines to target the NALT for eliciting protective immunity via the common mucosal immune system. ..
- IMMUNOBIOLOGY OF CLASS IB MOLECULESMark Soloski; Fiscal Year: 2004..abstract_text> ..
- TARGETED DNA DELIVERY FOR SALIVARY IGA RESPONSESDavid Pascual; Fiscal Year: 2004..These studies will provide the basis for future development of subunit vaccines to target the NALT for eliciting protective immunity in the oral cavity and SALT. ..
- Virulence Determinants in Helicobacter hepaticusRobert Maier; Fiscal Year: 2004..If specific mutants can be created, then virulence determinants can begin to be systematically studied. ..
- MECHANISM OF BCL-X EXPRESSION IN LYMPHOCYTES AND CANCERLAWRENCE BOISE; Fiscal Year: 2002..In addition determination of the methylation state of bcl-x in tumors may be a good indicator of the outcome of cancer chemotherapy of a given tumor. ..
- C REACTIVE PROTEIN IN HOST DEFENSEALEXANDER SZALAI; Fiscal Year: 2002..These studies will increase the understanding of innate host defense mechanisms and their interaction with acquired immunity. ..
- AUTOIMMUNE GASTRITIS INITIATED BY HELICOBACTER INFECTIONROBINNA LORENZ; Fiscal Year: 2002....
- CD4+ T CELLS RESPONDING TO SALMONELLA INFECTIONBrad Cookson; Fiscal Year: 2005..The protective Ags identified will be excellent candidates for components of subunit vaccines and markers of cellular immunity in humans. ..
- 2005 Antimicrobial Peptides Gordon ConferenceAndre Ouellette; Fiscal Year: 2005..The organizational philosophy is to encourage diverse participation, and maintain an eye towards gender issues, junior scientists, minorities, and individuals with physical limitations. ..
- Mucosal Vaccines for PlagueDavid Pascual; Fiscal Year: 2006..pestis challenge. From these studies, we will produce efficacious vaccines to plague, as well as a supporting vaccine regimen, that will confer protective immunity in the mucosal and systemic immune compartments. ..
- Nickel Metabolism in Helicobacter pyloriRobert Maier; Fiscal Year: 2006..The role of a DNA binding and nickel-sensing protein (NikR) is of particular interest as it may play a global regulatory role in metal homeostasis, in turn affecting many processes of cell metabolism. ..
- Oxidative Stress and Survival of Helicobacter pyloriRobert Maier; Fiscal Year: 2005....
- Induction of Macrophage iNOS by SalmonellaBOBBY CHERAYIL; Fiscal Year: 2006..The results of these studies will shed light on a novel function of SopE and SopE2 and will also improve understanding of the mechanisms that regulate iNOS expression. ..
- MUCOSAL IMMUNITY ELICITED BY SALMONELLA VACCINE DELIVERYDavid Pascual; Fiscal Year: 2009..Thus, from these studies we will learn the specific mechanisms induced by this anti-inflammatory vaccine. ..
- Targeted tumoricidal bacteriaMing Zhao; Fiscal Year: 2007..Future human trials of the tumor-killing bacteria can be held after the Phase I and Phase II grant periods are completed. [unreadable] [unreadable] [unreadable]..
- Orthotopic models of tumor angiogenesis and blood flowMeng Yang; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- Enzyme therapy for hyperhomocysteinemiaYuying Tan; Fiscal Year: 2005..Phase II results will lead to an IND for MEGC-PEG-rMETase for end stage renal disease patients and other patients with intractable hyperhomocysteinemia and high cardiovascular disease mortality. ..
- Opioid Dependence, Immunity and InfectionTOBY EISENSTEIN; Fiscal Year: 2005..Dissection of the mechanisms and pathways by which opioids interface with the immune system during withdrawal should elucidate fundamental interconnections between the neural and immune systems. ..
- RHOMOCYCSTEINASE FOR HOMOCYSTEINE ASSAYYuying Tan; Fiscal Year: 2002..The tHCY enzymatic kits for these applications will be ready for commercial launch at this point. PROPOSED COMMERCIAL APPLICATION: Not Available ..
- Inhibitors of 5alpha-reductase for acne therapyLingna Li; Fiscal Year: 2002..PROPOSED COMMERCIAL APPLICATIONS: Liposomal 4-MA will be developed as a topical selectively targeted therapeutic for acne for which they should be a very market. ..
- Discovery of novel fluorescent reporter genesMing Zhao; Fiscal Year: 2004..Reporters with spectral properties that can be used for whole-body imaging of tumors in the lung and their metastases will be candidates for further development for numerous applications of multi-color imaging. ..
- Adenoviral GFP targeting of metastatic human tumors using multiple delivery routeHiroyuki Kishimoto; Fiscal Year: 2008..Having obtained these results, we can move forward in the Phase II grant application with experiments to bring OBP-401 to the clinic for use in cancer surgery in human patients. [unreadable] [unreadable] [unreadable]..
- Therapeutic hair follicle-derived neurospheresMeng Yang; Fiscal Year: 2007..Human hair- follicle bulge cells will be further characterized and developed for therapeutic potential for nerve regeneration in Phase III. [unreadable]..
- Dual-color tumor-host imaging modelsMeng Yang; Fiscal Year: 2007..These models have significant commercial potential for discovery and development of stroma-targeted and anti-angiogenesis drugs. [unreadable] [unreadable] [unreadable]..
- Imageable tumor-targeting bacteriaMing Zhao; Fiscal Year: 2006..unreadable] [unreadable] [unreadable]..