animal mammary neoplasms

Summary

Summary: Tumors or cancer of the MAMMARY GLAND in animals (MAMMARY GLANDS, ANIMAL).

Top Publications

  1. ncbi Disruption of Ca2+-dependent cell-matrix adhesion enhances c-Src kinase activity, but causes dissociation of the c-Src/FAK complex and dephosphorylation of tyrosine-577 of FAK in carcinoma cells
    Eva H Lin
    Division of Cancer Biology and Genetics, Cancer Research Institute, Queen s University, Kingston, Ontario, Canada
    Exp Cell Res 293:1-13. 2004
  2. pmc Stromal effects on mammary gland development and breast cancer
    Bryony S Wiseman
    Department of Anatomy, University of California, 513 Parnassus Avenue, San Francisco, CA 94143, USA
    Science 296:1046-9. 2002
  3. pmc Colony-stimulating factor 1 promotes progression of mammary tumors to malignancy
    E Y Lin
    Department of Developmental and Molecular Biology, Center for the Study of Reproductive Biology and Women s Health, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA
    J Exp Med 193:727-40. 2001
  4. ncbi Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer
    J Jonkers
    Division of Molecular Genetics and Centre of Biomedical Genetics, Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands
    Nat Genet 29:418-25. 2001
  5. ncbi p63: a novel myoepithelial cell marker in canine mammary tissues
    A Gama
    Department of Pathology and Veterinary Clinics, University of Trás os Montes e Alro Douro, Vila Real, Portugal
    Vet Pathol 40:412-20. 2003
  6. ncbi A prospective analysis of immunohistochemically determined estrogen receptor alpha and progesterone receptor expression and host and tumor factors as predictors of disease-free period in mammary tumors of the dog
    J Martín de las Mulas
    Dpto de Anatomía y Anatomía Patológica Comparadas, Facultad de Veterinaria, Universidad de Cordoba, Sanidad Animal, Campus de Rabanales, Carretera de Madrid Cádiz, Km 396, 14014 Cordoba, Spain
    Vet Pathol 42:200-12. 2005
  7. ncbi Increased expression of BRCA2 and RAD51 in lymph node metastases of canine mammary adenocarcinomas
    R Klopfleisch
    Institute of Veterinary Pathology, Freie Universitat Berlin, Robert von Ostertag Strasse 15, 14163 Berlin, Germany
    Vet Pathol 46:416-22. 2009
  8. ncbi Comparison of steroid receptor expression in normal, dysplastic, and neoplastic canine and feline mammary tissues
    F Millanta
    Department of Animal Pathology, School of Veterinary Medicine, University of Pisa, Viale delle Piagge, 2, I 56124 Pisa, Italy
    Res Vet Sci 79:225-32. 2005
  9. pmc Sca-1 identifies the tumor-initiating cells in mammary tumors of BALB-neuT transgenic mice
    Cristina Grange
    Department of Internal Medicine, Molecular Biotechnology Center, University of Torino, Torino, Italy
    Neoplasia 10:1433-43. 2008
  10. ncbi High incidence of breast and endometrial neoplasia resembling human Cowden syndrome in pten+/- mice
    V Stambolic
    Amgen Research Institute and Ontario Cancer Institute, Toronto, Canada
    Cancer Res 60:3605-11. 2000

Research Grants

  1. Apoptotic Mechanisms of Tocotrienols in Mammary Cancer
    Paul Sylvester; Fiscal Year: 2004
  2. P53 AND MOUSE MAMMARY TUMORIGENESIS
    Daniel Medina; Fiscal Year: 2004
  3. MECHANISMS OF THE HORMONAL PREVENTION OF BREAST CANCER
    Daniel Medina; Fiscal Year: 2006
  4. BIO-ACTIVATION OF VITAMIN D IN MAMMARY GLAND
    JoEllen Welsh; Fiscal Year: 2004
  5. Characterization of the MMTV Receptor
    Susan Ross; Fiscal Year: 2006
  6. Genistein Impriting Against Prostate Cancer
    CORAL LAMARTINIERE; Fiscal Year: 2003
  7. Genetics of Susceptibility to MMTV-Induced Mammary Tumor
    Susan Ross; Fiscal Year: 2006
  8. Role of ITAM repeats in virus-induced breast cancer
    Susan R Ross; Fiscal Year: 2010
  9. In Utero Mammary Cancer Risk with Resveratrol and TCDD
    CORAL LAMARTINIERE; Fiscal Year: 2008
  10. In Utero TCDD Programming for Mammary Cancer
    CORAL LAMARTINIERE; Fiscal Year: 2005

Detail Information

Publications225 found, 100 shown here

  1. ncbi Disruption of Ca2+-dependent cell-matrix adhesion enhances c-Src kinase activity, but causes dissociation of the c-Src/FAK complex and dephosphorylation of tyrosine-577 of FAK in carcinoma cells
    Eva H Lin
    Division of Cancer Biology and Genetics, Cancer Research Institute, Queen s University, Kingston, Ontario, Canada
    Exp Cell Res 293:1-13. 2004
    ..These findings indicate an important role of integrin-based cell-matrix adhesion in regulating c-Src/FAK signaling under decreased anchorage conditions...
  2. pmc Stromal effects on mammary gland development and breast cancer
    Bryony S Wiseman
    Department of Anatomy, University of California, 513 Parnassus Avenue, San Francisco, CA 94143, USA
    Science 296:1046-9. 2002
    ..To find cures for diseases like breast cancer that rely on epithelial-stromal crosstalk, we must understand how these different cell types communicate with each other...
  3. pmc Colony-stimulating factor 1 promotes progression of mammary tumors to malignancy
    E Y Lin
    Department of Developmental and Molecular Biology, Center for the Study of Reproductive Biology and Women s Health, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA
    J Exp Med 193:727-40. 2001
    ..Our data suggest that agents directed at CSF-1/CSF-1R activity could have important therapeutic effects...
  4. ncbi Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer
    J Jonkers
    Division of Molecular Genetics and Centre of Biomedical Genetics, Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands
    Nat Genet 29:418-25. 2001
    ..Our results show that inactivation of BRCA2 and of p53 combine to mediate mammary tumorigenesis, and indicate that disruption of the p53 pathway is pivotal in BRCA2-associated breast cancer...
  5. ncbi p63: a novel myoepithelial cell marker in canine mammary tissues
    A Gama
    Department of Pathology and Veterinary Clinics, University of Trás os Montes e Alro Douro, Vila Real, Portugal
    Vet Pathol 40:412-20. 2003
    ..In conclusion, the present study reveals p63 as a sensitive and highly specific marker of myoepithelial cells in canine mammary tissues, and the authors suggest p63 as an additional marker for defining myoepithelial histogenesis...
  6. ncbi A prospective analysis of immunohistochemically determined estrogen receptor alpha and progesterone receptor expression and host and tumor factors as predictors of disease-free period in mammary tumors of the dog
    J Martín de las Mulas
    Dpto de Anatomía y Anatomía Patológica Comparadas, Facultad de Veterinaria, Universidad de Cordoba, Sanidad Animal, Campus de Rabanales, Carretera de Madrid Cádiz, Km 396, 14014 Cordoba, Spain
    Vet Pathol 42:200-12. 2005
    ..The most frequent groups of hormone receptors-positive tumors were the ERalpha-positive and PR-positive group among benign and the ERalpha-negative and PR-positive group among malignant tumors...
  7. ncbi Increased expression of BRCA2 and RAD51 in lymph node metastases of canine mammary adenocarcinomas
    R Klopfleisch
    Institute of Veterinary Pathology, Freie Universitat Berlin, Robert von Ostertag Strasse 15, 14163 Berlin, Germany
    Vet Pathol 46:416-22. 2009
    ..Further experimental studies are needed to clarify whether these changes in gene expression are a direct carcinogenetic stimulus or a protective response due to genetic instability during tumor progression...
  8. ncbi Comparison of steroid receptor expression in normal, dysplastic, and neoplastic canine and feline mammary tissues
    F Millanta
    Department of Animal Pathology, School of Veterinary Medicine, University of Pisa, Viale delle Piagge, 2, I 56124 Pisa, Italy
    Res Vet Sci 79:225-32. 2005
    ..The low percentage of ER-positive invasive carcinomas further demonstrated the aggressive phenotype and behaviour of feline mammary tumours...
  9. pmc Sca-1 identifies the tumor-initiating cells in mammary tumors of BALB-neuT transgenic mice
    Cristina Grange
    Department of Internal Medicine, Molecular Biotechnology Center, University of Torino, Torino, Italy
    Neoplasia 10:1433-43. 2008
    ..The data of the present study indicate that a Sca-1(+) population derived from mammary BALB-neuT tumors is responsible for sphere generation in culture and for initiating tumors in vivo...
  10. ncbi High incidence of breast and endometrial neoplasia resembling human Cowden syndrome in pten+/- mice
    V Stambolic
    Amgen Research Institute and Ontario Cancer Institute, Toronto, Canada
    Cancer Res 60:3605-11. 2000
    ..Taken together, our results establish pten+/- mice as an excellent animal model system for the investigation of PTEN-related hamartoma syndromes, as well as the role of PTEN in breast and endometrial carcinogenesis...
  11. ncbi Induction of strong antitumor immunity by an HSV-2-based oncolytic virus in a murine mammary tumor model
    Hongtao Li
    Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA
    J Gene Med 9:161-9. 2007
    ..We conclude that the HSV-2-based FusOn-H2 oncolytic virus may be an effective agent for the treatment of both primary and metastatic breast cancer...
  12. ncbi Of humans and canines: Immunohistochemical analysis of PCNA, Bcl-2, p53, cytokeratin and ER in mammary tumours
    R Kumaraguruparan
    Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar 608 002, Chidambaram, Tamil Nadu, India
    Res Vet Sci 81:218-24. 2006
    ..The changes in proliferation, apoptosis and differentiation associated proteins in human and canine mammary tumours validate use of the canine model to understand the molecular mechanisms of mammary carcinogenesis...
  13. pmc Hormone-induced protection of mammary tumorigenesis in genetically engineered mouse models
    Lakshmanaswamy Rajkumar
    Department of Pathology, Texas Tech University Health Sciences Center, 4800 Alberta Avenue, El Paso, TX 79905, USA
    Breast Cancer Res 9:R12. 2007
    ..The experiments reported here address the question of whether a short-term hormone treatment can prevent mammary tumorigenesis in two different genetically engineered mouse models...
  14. ncbi The role of Tbx2 and Tbx3 in mammary development and tumorigenesis
    Matthew Rowley
    Department of Laboratory Medicine and Pathology, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    J Mammary Gland Biol Neoplasia 9:109-18. 2004
    ..Here we review the current information on the roles of Tbx2 and Tbx3 in mammary gland development and tumorigenesis...
  15. ncbi DNA vaccination with full-length or truncated neu induces protective immunity against the development of spontaneous mammary tumors in HER-2/neu transgenic mice
    A Amici
    General Physiology Laboratory of Genetic Immunization, Department of Biology MCA, University of Camerino, Camerino, Italy
    Gene Ther 7:703-6. 2000
    ..Our data demonstrate the effectiveness of DNA vaccination using truncated Neu plasmids in inducing antitumor protection in a spontaneous mammary tumor model...
  16. ncbi Protein kinase CK2 in mammary gland tumorigenesis
    E Landesman-Bollag
    Department of Medicine, Boston Medical Center, Boston, Massachusetts, MA 02118 2394, USA
    Oncogene 20:3247-57. 2001
    ..Thus, in mice, rats, and humans, dysregulated expression of CK2 is associated with and is capable of contributing to mammary tumorigenesis. Targeted inhibition of CK2 could be useful in the treatment of breast cancer...
  17. ncbi Immunohistologic detection of estrogen receptor alpha in canine mammary tumors: clinical and pathologic associations and prognostic significance
    A Nieto
    Department of Animal Pathology II, Veterinary School, Universidad Complutense de Madrid, Spain
    Vet Pathol 37:239-47. 2000
    ..The immunohistochemical detection of ER-alpha in canine mammary tumors is a simple technique with prognostic value that could be useful in selecting appropriate hormonal therapy...
  18. pmc Genetic mechanisms in Apc-mediated mammary tumorigenesis
    Mari Kuraguchi
    Harvard Partners Center for Genetics and Genomics, Harvard Medical School, Boston, Massachusetts, USA
    PLoS Genet 5:e1000367. 2009
    ....
  19. pmc Adipocyte-derived collagen VI affects early mammary tumor progression in vivo, demonstrating a critical interaction in the tumor/stroma microenvironment
    Puneeth Iyengar
    Department of Cell Biology, Albert Einstein Cancer Center, Albert Einstein College of Medicine, New York, New York 10461, USA
    J Clin Invest 115:1163-76. 2005
    ..Therefore, adipocytes play a vital role in defining the ECM environment for normal and tumor-derived ductal epithelial cells and contribute significantly to tumor growth at early stages through secretion and processing of collagen VI...
  20. pmc Concordant morphologic and gene expression data show that a vaccine halts HER-2/neu preneoplastic lesions
    Elena Quaglino
    Department of Clinical and Biological Sciences, University of Turin, Orbassano, Italy
    J Clin Invest 113:709-17. 2004
    ..This finding suggests that a new way can be found to secure the immunologic control of the progression of HER-2/neu preneoplastic lesions...
  21. ncbi Secreted frizzled-related protein 2 (SFRP2) is highly expressed in canine mammary gland tumors but not in normal mammary glands
    Jia Lin Lee
    Department and Graduate Institute of Veterinary Medicine, College of Bio Resources and Agriculture, National Taiwan University, Taiwan, ROC
    Breast Cancer Res Treat 84:139-49. 2004
    ....
  22. pmc Blockade of TGF-beta inhibits mammary tumor cell viability, migration, and metastases
    Rebecca S Muraoka
    Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 27232, USA
    J Clin Invest 109:1551-9. 2002
    ..Therefore, blockade of TGF-beta signaling may reduce tumor cell viability and migratory potential and represents a testable therapeutic approach against metastatic carcinomas...
  23. ncbi Immunohistochemical expression of p63 and deltaNp63 in mixed tumors of canine mammary glands and its relation with p53 expression
    A C Bertagnolli
    Laboratory of Comparative Pathology, Depto De Patologia Geral ICB UFMG Cx postal 486, CEP 31270 901, Brazil
    Vet Pathol 46:407-15. 2009
    ..Our data support the notion that the decrease of p63 expression, in particular of its isoform DeltaNp63, seems to be an important factor in the development of carcinomas in mixed tumors...
  24. ncbi Metformin decelerates aging and development of mammary tumors in HER-2/neu transgenic mice
    V N Anisimov
    Prof N N Petrov Institute of Oncology, Ministry of Health of the Russian Federation, St Petersburg, Moscow
    Bull Exp Biol Med 139:721-3. 2005
    ..Hence, we first demonstrated a geroprotective effect of metformin and its suppressive effect towards the development of mammary tumors...
  25. ncbi Adjuvant post-operative chemotherapy in bitches with mammary cancer
    M Karayannopoulou
    Department of Clinical Sciences, Clinic of Surgery, Faculty of Veterinary Medicine, Aristotle University of Thessaloniki, St Voutyra 11, 546 27 Thessaloniki
    J Vet Med A Physiol Pathol Clin Med 48:85-96. 2001
    ..05) but within normal limits. Creatinine was also increased significantly (P < 0.01) but the mean creatinine concentrations were within normal limits, although in half of the bitches the concentrations occasionally rose above normal...
  26. ncbi Genetic interactions between tumor suppressors Brca1 and p53 in apoptosis, cell cycle and tumorigenesis
    X Xu
    Genetics of Development and Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, 10 9N105, Bethesda, Maryland, USA
    Nat Genet 28:266-71. 2001
    ..These findings provide a mechanism for BRCA1-associated breast carcinogenesis...
  27. ncbi gamma-Tocotrienol inhibits ErbB3-dependent PI3K/Akt mitogenic signalling in neoplastic mammary epithelial cells
    G V Samant
    College of Pharmacy, University of Louisiana at Monroe, Monroe, LA 71209 0470, USA
    Cell Prolif 39:563-74. 2006
    ....
  28. pmc Human recombinant erythropoietin (rEpo) has no effect on tumour growth or angiogenesis
    M E Hardee
    Department of Pathology, Duke University Medical Center, Box 3893, Durham, NC 27710, USA
    Br J Cancer 93:1350-5. 2005
    ..These studies also suggest that further preclinical studies need to examine rEpo's direct tumour effects in efforts to improve the therapeutic benefits of Epo in solid tumour patients...
  29. ncbi Prognostic factors associated with survival two years after surgery in dogs with malignant mammary tumors: 79 cases (1998-2002)
    Shih Chieh Chang
    Department of Veterinary Medicine, Veterinary Medical Teaching Hospital, Taiwan National Chung Hsing University, Taichung
    J Am Vet Med Assoc 227:1625-9. 2005
    ..To identify prognostic factors for female dogs that have undergone surgical removal of malignant mammary tumors...
  30. ncbi Progesterone receptors in normal, dysplastic and tumourous feline mammary glands. Comparison with oestrogen receptors status
    J Martin de las Mulas
    Department of Comparative Pathology, University of Cordoba, Spain
    Res Vet Sci 72:153-61. 2002
    ..02). Oestrogen receptors, detected by either method, were also detected in half the cases in which PR had been detected. In malignant tumours, the most prevalent groups were the ER + PR + and ER-PR + groups...
  31. ncbi Mechanisms mediating the antiproliferative and apoptotic effects of vitamin E in mammary cancer cells
    Paul W Sylvester
    School of Pharmacy, 700 University Avenue, University of Louisiana at Monroe, Monroe, LA 71209 0470, USA
    Front Biosci 10:699-709. 2005
    ....
  32. pmc ErbB2 is required for ductal morphogenesis of the mammary gland
    Amy J Jackson-Fisher
    Department of Pathology, Yale University School of Medicine, New Haven, CT 06520 8023, USA
    Proc Natl Acad Sci U S A 101:17138-43. 2004
    ..Lobuloalveolar development was not affected in glands that developed from ErbB2(-/-) transplanted tissue. The results may have implications for the aggressive phenotypes associated with ERBB2-overexpressing mammary carcinomas...
  33. ncbi Expression of connexins 26 and 43 in canine hyperplastic and neoplastic mammary glands
    L N Torres
    Department of Pathology, Faculty of Veterinary Medicine and Zootechny, University of Sao Paulo, Av Prof Orlando Marques de Paiva, 87 Cidade Universitária CEP 05508 900, Sao Paulo SP, Brazil
    Vet Pathol 42:633-41. 2005
    ....
  34. ncbi Inflammatory mammary carcinoma in dogs: 33 cases (1995-1999)
    M D Perez Alenza
    Department of Animal Pathology II, Veterinary Teaching Hospital, School of Veterinary Medicine, Complutense University, Madrid, Spain
    J Am Vet Med Assoc 219:1110-4. 2001
    ..To determine epidemiologic, clinical, and pathologic characteristics of inflammatory mammary carcinoma (IC) in dogs...
  35. ncbi An epistatic interaction controls the latency of a transgene-induced mammary tumor
    T Le Voyer
    Division of Population Science, Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, Pennsylvania 19111, USA
    Mamm Genome 11:883-9. 2000
    ..These loci, designated Apmt1 and Apmt2, map to homologous regions associated with LOH in human breast cancer. These results suggest that allelic variants of genes in these regions may contribute to age of onset in human breast cancer...
  36. ncbi c-erbB-2 expression and nuclear pleomorphism in canine mammary tumors
    A P Dutra
    Laboratorio de Patologia Comparada, Departamento de Patologia Geral, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil
    Braz J Med Biol Res 37:1673-81. 2004
    ..It was also possible to show that the immunoexpression of c-erbB-2 can be a factor in mammary carcinogenesis. This fact opens the possibility of using anti-c-erbB-2 antibodies in the treatment of canine mammary tumors...
  37. ncbi Immunobiology of her-2/neu transgenic mice
    Tania Pannellini
    Aging Research Center, University G d Annunzio Foundation, Chieti, Italy
    Breast Dis 20:33-42. 2004
    ..This suggests that induction of a specific immune reaction against a tumor target antigen may provide a way of preventing the onset of tumours in subjects with a high genetic risk of developing cancer...
  38. ncbi Cure of mammary carcinomas in Her-2 transgenic mice through sequential stimulation of innate (neoadjuvant interleukin-12) and adaptive (DNA vaccine electroporation) immunity
    Michela Spadaro
    Department of Clinical and Biological Sciences, University of Turin, Ospedale San Luigi Gonzaga, Regione Gonzole 10, I 10043 Orbassano, Italy
    Clin Cancer Res 11:1941-52. 2005
    ..In a model of Her-2 spontaneous mammary cancer, we investigated the efficacy of neoadjuvant interleukin 12 (IL-12) followed by "immune-surgery" of the residual tumor...
  39. ncbi Factors that influence the penetration of methotrexate through solid tissue
    D S Cowan
    Department of Medicine, Ontario Cancer Institute and University of Toronto, Ontario, Canada
    Int J Cancer 91:120-5. 2001
    ..Our data provide evidence that tissue penetration of methotrexate is through the extracellular space, that its distribution in solid tissue may be limited and that it may be possible to improve its tissue penetration...
  40. ncbi Phosphatidylinositol 3' kinase signaling in mammary tumorigenesis
    M P Scheid
    Ontario Cancer Institute, Toronto, Canada
    J Mammary Gland Biol Neoplasia 6:83-99. 2001
    ..This review summarizes the players involved, their importance in human cancer and their specific involvement in breast cancer...
  41. ncbi E-cadherin expression in canine malignant mammary tumours: relationship to other clinico-pathological variables
    A J F Matos
    Institute of Biomedical Sciences of Abel Salazar ICBAS, University of Porto, Portugal
    J Comp Pathol 134:182-9. 2006
    ..The significant relationship between E-cadherin and other known factors of poor prognosis suggests that the loss of E-cadherin expression may have prognostic value in canine malignant mammary tumours...
  42. ncbi Methylseleninic acid, a potent growth inhibitor of synchronized mouse mammary epithelial tumor cells in vitro
    R Sinha
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, 77030, Houston, TX, USA
    Biochem Pharmacol 61:311-7. 2001
    ..The results provide experimental support for the hypothesis that monomethylated forms of Se are the critical effector molecules in Se-mediated growth inhibition in vitro...
  43. pmc Pregnancy-induced changes in cell-fate in the mammary gland
    Melanie R Ginger
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA
    Breast Cancer Res 5:192-7. 2003
    ..Recent studies signify a dramatic advance in our understanding of this phenomenon, and indicate a 'cell fate' model for parity-related changes that lead to protection against breast cancer...
  44. ncbi Of humans and canines: a comparative evaluation of heat shock and apoptosis-associated proteins in mammary tumors
    Ramasamy Kumaraguruparan
    Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar 608 002, Tamil Nadu, India
    Clin Chim Acta 365:168-76. 2006
    ..We investigated the expression of heat shock proteins (Hsps) as well as apoptosis-associated proteins in both human and canine mammary tumors...
  45. pmc Lifetime exposure to a soluble TGF-beta antagonist protects mice against metastasis without adverse side effects
    Yu An Yang
    Laboratory of Cell Regulation and Carcinogenesis, National Cancer Institute, Bethesda, Maryland 20892, USA
    J Clin Invest 109:1607-15. 2002
    ..Thus this soluble TGF-beta antagonist has potential for long-term clinical use in the prevention of metastasis...
  46. ncbi The role of C/EBPbeta in mammary gland development and breast cancer
    Sandra L Grimm
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Mammary Gland Biol Neoplasia 8:191-204. 2003
    ..Thus, C/EBPbeta appears to play a role in the specification of progenitor cell fate not only in the mammary gland, but also in a number of other tissues...
  47. pmc The transforming activity of Wnt effectors correlates with their ability to induce the accumulation of mammary progenitor cells
    Bob Y Liu
    McArdle Laboratory for Cancer Research, University of Wisconsin Medical School, 1400 University Avenue, Madison, WI 53706 1599, USA
    Proc Natl Acad Sci U S A 101:4158-63. 2004
    ..We propose that the growth dynamic of the stem cell fraction is a major determinant of tumor susceptibility...
  48. ncbi Next stop, the twilight zone: hedgehog network regulation of mammary gland development
    Michael T Lewis
    Baylor College of Medicine, Houston, Texas 77030, USA
    J Mammary Gland Biol Neoplasia 9:165-81. 2004
    ..Further, studies suggest a role for misregulated network function in the progression of breast cancer...
  49. ncbi Deregulation of Stat5 expression and activation causes mammary tumors in transgenic mice
    Elena Iavnilovitch
    Institute of Animal Science, Agricultural Research Organization, Volcani Center, Bet Dagan, Israel
    Int J Cancer 112:607-19. 2004
    ..The transactivation function of Stat5 is involved in the determination of tumors with a more differentiated phenotype...
  50. pmc Induction of mammary gland ductal hyperplasias and carcinoma in situ following fetal bisphenol A exposure
    Tessa J Murray
    Department of Anatomy and Cellular Biology, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, United States
    Reprod Toxicol 23:383-90. 2007
    ..Thus, fetal bisphenol A exposure is sufficient to induce the development of preneoplastic and neoplastic lesions in the mammary gland in the absence of any additional treatment aimed at increasing tumor development...
  51. pmc ApcMin, a mutation in the murine Apc gene, predisposes to mammary carcinomas and focal alveolar hyperplasias
    A R Moser
    McArdle Laboratory for Cancer Research, University of Wisconsin, Madison 53706
    Proc Natl Acad Sci U S A 90:8977-81. 1993
    ..Long-term grafts of Min/+ mammary glands also gave rise to focal alveolar hyperplasias, indicating that the presence of the Min mutation also has a role in the development of these lesions...
  52. pmc Host microenvironment in breast cancer development: epithelial-mesenchymal transition in breast cancer development
    Anne Vincent-Salomon
    Medical Division, Department of Tumor Biology, Institut Curie, Paris, France
    Breast Cancer Res 5:101-6. 2003
    ..DNA profiling technology is also being applied to uncover pathways that lead to a metastatic phenotype...
  53. pmc The mouse mammary carcinoma 4T1: characterization of the cellular landscape of primary tumours and metastatic tumour foci
    Sally A Dupré
    Department of Microbiology and Immunology, University of Nevada School of Medicine, Reno, NV 89557, USA
    Int J Exp Pathol 88:351-60. 2007
    ..This pathologic presentation correlated with the expression of tumour-derived chemokines...
  54. pmc IL-1 is required for tumor invasiveness and angiogenesis
    Elena Voronov
    Department of Microbiology and Immunology, Faculty of Health Sciences, The Cancer Research Center, Ben Gurion University of the Negev, Beer Sheva 84105, Israel
    Proc Natl Acad Sci U S A 100:2645-50. 2003
    ..Furthermore, the anti-angiogenic effects of IL-1 receptor antagonist, shown here, suggest a possible therapeutic role in cancer, in addition to its current use in rheumatoid arthritis...
  55. ncbi The genetic background modifies the spontaneous and X-ray-induced tumor spectrum in the Apc1638N mouse model
    C W van der Houven van Oordt
    Department of Molecular Carcinogenesis, Leiden University, The Netherlands
    Genes Chromosomes Cancer 24:191-8. 1999
    ..The opposite was noted for the cyst multiplicity after X-rays. Surprisingly, X-irradiated CB6F1-Apc1638N females were highly susceptible to the development of ovarian tumors, which displayed clear loss of the wild-type Apc allele...
  56. ncbi Cadherins and the mammary gland
    Karen A Knudsen
    Lankenau Institute for Medical Research, Wynnewood, PA 19096, USA
    J Cell Biochem 95:488-96. 2005
    ..Additional research is needed to more precisely define the roles of both classical and desmosomal cadherins and their downstream signaling events, in the development and malignant behavior of breast cancers...
  57. ncbi NF-kappaB in mammary gland development and breast cancer
    Yixue Cao
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California, San Diego, La Jolla, California 92093, USA
    J Mammary Gland Biol Neoplasia 8:215-23. 2003
    ..Elevated NF-kappaB DNA-binding activity is detected in both mammary carcinoma cell lines and primary human breast cancer tissues...
  58. ncbi Lipid-rich carcinomas of the mammary gland in seven dogs: clinicopathologic and immunohistochemical features
    A Espinosa de los Monteros
    Departamento de Morfologia, Facultad de Veterinaria, Universidad de Las Palmas de Gran Canaria, Trasmontana s n, 35416 Arucas, La Palmas, Spain
    Vet Pathol 40:718-23. 2003
    ..All tumors lacked both estrogen and progesterone receptors, and five out of seven tumors gave rise to local recurrence and proximal or distant metastases or both...
  59. pmc Host microenvironment in breast cancer development: epithelial-cell-stromal-cell interactions and steroid hormone action in normal and cancerous mammary gland
    Sandra Z Haslam
    Department of Physiology, Michigan State University, East Lansing, MI, USA
    Breast Cancer Res 5:208-15. 2003
    ....
  60. pmc Functional interaction between mouse erbB3 and wild-type rat c-neu in transgenic mouse mammary tumor cells
    Aeree Kim
    Department of Pathology and College of Medicine, Oklahoma University Health Sciences Center OUHSC, Oklahoma City, OK, USA
    Breast Cancer Res 7:R708-18. 2005
    ..We hypothesized that physical and functional interactions between the wt rat neu/ErbB2 transgene and mouse ErbB3-encoded proteins could occur, activating downstream signaling and promoting mammary oncogenesis...
  61. ncbi Canine inflammatory mammary carcinoma: histopathology, immunohistochemistry and clinical implications of 21 cases
    Laura Peña
    Department of Animal Pathology II, Veterinary Teaching Hospital, School of Veterinary Medicine, Complutense University, Madrid, Spain
    Breast Cancer Res Treat 78:141-8. 2003
    ..Progestins and endocrine-related mechanisms seem to be involved in canine IC development. Canine IC could serve as a spontaneous model for human IBC, particularly in studies concerned with new therapeutics approaches...
  62. ncbi beta-catenin is a downstream effector of Wnt-mediated tumorigenesis in the mammary gland
    J S Michaelson
    Howard Hughes Medical Institute, Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Oncogene 20:5093-9. 2001
    ..These observations support the notion that the oncogenic Wnt pathway operates via beta-catenin and its targets in the context of mammary hyperplasia and carcinoma...
  63. pmc neu/ERBB2 cooperates with p53-172H during mammary tumorigenesis in transgenic mice
    B Li
    Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06520 8023, USA
    Mol Cell Biol 17:3155-63. 1997
    ..In these bitransgenic mice, we have recapitulated two common genetic lesions that occur in human breast cancer and have shown that p53 mutation is an important cooperating event in neu-mediated oncogenesis...
  64. ncbi Dietary modulation of pregnancy estrogen levels and breast cancer risk among female rat offspring
    Leena Hilakivi-Clarke
    Department of Oncology, Lombardi Cancer Center, Washington, DC 20007, USA
    Clin Cancer Res 8:3601-10. 2002
    ....
  65. ncbi Identification of molecular phenotypes in canine mammary carcinomas with clinical implications: application of the human classification
    A Gama
    Department of Veterinary Sciences, CECAV, University of Trás os Montes and Alto Douro UTAD, 5001 811, Vila Real, Portugal
    Virchows Arch 453:123-32. 2008
    ....
  66. ncbi Reduced tumorigenesis in mouse mammary cancer cells following inhibition of Pea3- or Erm-dependent transcription
    Virginie Firlej
    UMR 8161, Institut de Biologie de Lille, CNRS Universités de Lille 1 and 2, Institut Pasteur de Lille, IFR 142, BP 447, 1 rue Calmette, 59021 Lille Cedex, France
    J Cell Sci 121:3393-402. 2008
    ....
  67. pmc Development of spontaneous mammary tumors in BALB/c p53 heterozygous mice. A model for Li-Fraumeni syndrome
    C Kuperwasser
    Program in Molecular and Cellular Biology, Department of Veterinary and Animal Sciences, University of Massachusetts, Amherst, Massachusetts, USA
    Am J Pathol 157:2151-9. 2000
    ..These results demonstrate the critical role that the p53 tumor suppressor gene plays in preventing tumorigenesis in the mammary gland...
  68. ncbi Green tea extracts decrease carcinogen-induced mammary tumor burden in rats and rate of breast cancer cell proliferation in culture
    K T Kavanagh
    Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Cell Biochem 82:387-98. 2001
    ..In culture, inhibition of human breast cancer cell proliferation by EGCG was mediated in part via induction of the p27(Kip1) CKI...
  69. ncbi Expression of bone morphogenetic protein-6 (BMP-6) in myoepithelial cells in canine mammary gland tumors
    S Tateyama
    Department of Veterinary Pathology, Faculty of Agriculture, Miyazaki University, Japan
    Vet Pathol 38:703-9. 2001
    ....
  70. ncbi Adiponectin as a negative regulator in obesity-related mammary carcinogenesis
    Yu Wang
    Genome Research Center, University of Hong Kong, Hong Kong SAR, China
    Cell Res 17:280-2. 2007
  71. ncbi Tocotrienol-induced cytotoxicity is unrelated to mitochondrial stress apoptotic signaling in neoplastic mammary epithelial cells
    Sumit J Shah
    School of Pharmacy, University of Louisiana at Monroe, Monroe, LA 71209 0470, USA
    Biochem Cell Biol 83:86-95. 2005
    ..In summary, these findings clearly demonstrate that tocotrienol-induced apoptosis occurs independently of mitochondrial stress apoptotic signaling in neoplastic +SA mammary epithelial cells...
  72. ncbi Overexpression of HER-2 in feline invasive mammary carcinomas: an immunohistochemical survey and evaluation of its prognostic potential
    F Millanta
    Department of Animal Pathology, School of Veterinary Medicine, Viale delle Piagge 2, Pisa I 56124, Italy
    Vet Pathol 42:30-4. 2005
    ..As in the human oncology practice, the identification of the FMCs that overexpress HER-2 may also promote new therapeutic strategies...
  73. ncbi A rat model of bone cancer pain induced by intra-tibia inoculation of Walker 256 mammary gland carcinoma cells
    Qi Liang Mao-Ying
    Department of Integrative Medicine and Neurobiology, Shanghai Medical College, Fudan University, China
    Biochem Biophys Res Commun 345:1292-8. 2006
    ..In summary, the present study provided a useful and easily established rat model of bone cancer pain which will contribute to further study of the mechanisms underlying cancer pain...
  74. ncbi Evaluation of accuracy of fine needle aspiration cytology for diagnosis of canine mammary tumours: comparative features with human tumours
    G D Cassali
    Laboratorio de Patologia Comparada, Depto Patologia Geral ICB UFMG, Belo Horizonte, MG, Brazil
    Cytopathology 18:191-6. 2007
    ....
  75. ncbi Plasticity of cloned canine mammary spindle cell tumor, osteosarcoma and carcinoma cells
    H Wensman
    Department of Anatomy, Physiology and Biochemistry, Swedish University of Agricultural Sciences, Uppsala, Sweden
    Vet Pathol 45:803-15. 2008
    ..Our results point to plasticity in canine mammary tumors, as shown both by morphologic criteria and by expression patterns for lineage specific markers...
  76. ncbi The Wnt signaling receptor Lrp5 is required for mammary ductal stem cell activity and Wnt1-induced tumorigenesis
    Charlotta Lindvall
    Laboratory of Cell Signaling and Carcinogenesis, Van Andel Research Institute, Grand Rapids, Michigan 49503, USA
    J Biol Chem 281:35081-7. 2006
    ..These findings suggest that Lrp5-mediated canonical signaling is required for mammary ductal stem cell activity and for tumor development in response to oncogenic Wnt effectors...
  77. ncbi Cytologic examination of fine-needle aspirates from mammary gland tumors in the dog: diagnostic accuracy with comparison to histopathology and association with postoperative outcome
    Daniela Simon
    Small Animal Hospital, University of Veterinary Medicine, Hannover, Germany
    Vet Clin Pathol 38:521-8. 2009
    ..Malignant tumors may carry a poor prognosis and necessitate surgery. Few data are available on the value of cytologic examination as a diagnostic or prognostic tool for mammary tumors in dogs...
  78. ncbi Loss of p27 expression in canine mammary tumors and their metastases
    R Klopfleisch
    Department of Veterinary Pathology, Freie Universitat Berlin, Robert von Ostertag Strasse 15, 14163 Berlin, Germany
    Res Vet Sci 88:300-3. 2010
    ....
  79. ncbi Wnt-1 is dominant over neu in specifying mammary tumor expression profiles
    Shixia Huang
    Breast Center, Baylor College of Medicine, Houston, TX 77030, USA
    Technol Cancer Res Treat 5:565-71. 2006
    ..These observations suggest that Wnt-1 is dominant over Neu in specifying mammary tumor expression profiles...
  80. pmc Different gene-expression profiles for the poorly differentiated carcinoma and the highly differentiated papillary adenocarcinoma in mammary glands support distinct metabolic pathways
    Tali Eilon
    Institute of Animal Science, ARO, The Volcani Center, Bet Dagan, Israel
    BMC Cancer 8:270. 2008
    ..To distinguish the genes and elucidate the cellular processes and metabolic pathways utilized to preserve these phenotypes, gene-expression profiles were analyzed...
  81. pmc ETV6-NTRK3 fusion oncogene initiates breast cancer from committed mammary progenitors via activation of AP1 complex
    Zhe Li
    Division of Hematology Oncology, Children s Hospital Boston, Boston, MA 02115, USA
    Cancer Cell 12:542-58. 2007
    ..Given the increasing relevance of chromosomal translocations in epithelial cancers, such mice serve as a paradigm for the study of their genetic pathogenesis and cellular origins, and generation of preclinical models...
  82. ncbi Complex mammary tumours in the female dog: a review
    Eva Hellmén
    Department of Anatomy and Physiology, SLUBox 7011, SE 750 07 Uppsala, Sweden
    J Dairy Res 72:90-7. 2005
  83. pmc Sialyl Lewis x expression in canine malignant mammary tumours: correlation with clinicopathological features and E-Cadherin expression
    Salomé S Pinho
    Institute of Molecular Pathology and Immunology of the University of Porto IPATIMUP, Porto, Portugal
    BMC Cancer 7:124. 2007
    ..The aim of this study was to analyse the sLex expression in canine malignant mammary tumours and to evaluate if the presence of sLex correlates with the expression of E-Cadherin and with clinicopathological features...
  84. ncbi Expression of E-cadherin, P-cadherin and beta-catenin in canine malignant mammary tumours in relation to clinicopathological parameters, proliferation and survival
    Adelina Gama
    Department of Veterinary Sciences, University of Trás os Montes and Alto Douro UTAD, 5001 911 Vila Real, Portugal
    Vet J 177:45-53. 2008
    ..Abnormal expression of adhesion molecules is a common phenomenon in canine mammary malignant tumours and may play a central role in tumour progression...
  85. pmc In vivo positron-emission tomography imaging of progression and transformation in a mouse model of mammary neoplasia
    Craig K Abbey
    Department of Biomedical Engineering, University of California, One Shields Avenue, Davis, CA 95616, USA
    Proc Natl Acad Sci U S A 101:11438-43. 2004
    ..Furthermore, quantitative markers of disease extracted from the images can be used to track proliferation and progression in vivo over multiple time points...
  86. ncbi Synergistic antiproliferative effects of gamma-tocotrienol and statin treatment on mammary tumor cells
    Vikram B Wali
    College of Pharmacy, University of Louisiana at Monroe, 700 University Ave, Monroe, LA 71209 0470, USA
    Lipids 42:1113-23. 2007
    ....
  87. ncbi Cyclopedic protein expression analysis of cultured canine mammary gland adenocarcinoma cells from six tumours
    T Nakagawa
    Laboratory of Veterinary Surgery, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Res Vet Sci 80:317-23. 2006
    ....
  88. ncbi Histological grading and prognosis in dogs with mammary carcinomas: application of a human grading method
    M Karayannopoulou
    Department of Clinical Studies, School of Veterinary Medicine, Aristotle University of Thessaloniki, St Voutyra 11, 546 27, Thessaloniki, Greece
    J Comp Pathol 133:246-52. 2005
    ..001). Routine use of this human grading method would help the clinician to make a more accurate prognosis in the interests of post-surgical management in dogs with mammary carcinomas...
  89. ncbi Stem cells and mammary cancer in mice
    Gibert H Smith
    Mammary Biology and Tumorigenesis Laboratory, Center for Cancer Research, National Cancer Institute, Bethesda, MD 10892, USA
    Stem Cell Rev 1:215-23. 2005
    ..Retroviral marking via MMTV proviral insertion demonstrates that this process progresses from a single mammary epithelial cell that possesses all the features ascribed to tissue-specific stem cells...
  90. pmc A comparative study between mixed-type tumours from human salivary and canine mammary glands
    Marisa C L S Genelhu
    Laboratory of Comparative Pathology, Biological Sciences Institute, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
    BMC Cancer 7:218. 2007
    ..The aim of the study was to compare clinical, morphological and immunohistochemical features of human salivary and canine mammary gland mixed tumours, in order to evaluate the latter as an experimental model for salivary gland tumours...
  91. ncbi In vivo responses to vaccination with Mage-b, GM-CSF and thioglycollate in a highly metastatic mouse breast tumor model, 4T1
    Claudia Gravekamp
    California Pacific Medical Center Research Institute, 475 Brannan Street, San Francisco, CA 94107, USA
    Cancer Immunol Immunother 57:1067-77. 2008
    ..Whether the interaction between Fas and FasL may have contributed to the smaller tumors needs to be further analyzed...
  92. ncbi Multiple genetic changes are associated with mammary tumorigenesis in Brca1 conditional knockout mice
    S G Brodie
    Genetics of Development and Disease Branch, 10 9N105, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Oncogene 20:7514-23. 2001
    ..Despite their distinct morphology, all cultured tumor cells were Tamoxifen resistant but highly sensitive to Doxorubicin or gamma-irradiation, suggesting that these methods would be effective in treatment of this disease...
  93. ncbi Beta-catenin and Tcfs in mammary development and cancer
    Sarah Hatsell
    Department of Cell Biology, New York University School of Medicine, New York, New York 10016, USA
    J Mammary Gland Biol Neoplasia 8:145-58. 2003
    ..Cyclin D1, however, is dispensable for tumor formation and the initiation of alveologenesis but is essential for later alveolar expansion...
  94. ncbi Spontaneous pituitary abnormalities and mammary hyperplasia in FVB/NCr mice: implications for mouse modeling
    Lalage M Wakefield
    Laboratory of Cell Regulation and Carcinogenesis, National Cancer Institute, Bethesda, Maryland 20892, USA
    Comp Med 53:424-32. 2003
    ..This high prevalence of pituitary abnormalities and their effects on the mammary gland have important consequences for the interpretation of new phenotypes generated in transgenic models using this mouse substrain...
  95. ncbi Oncogene HER-2 in canine mammary gland carcinomas: an immunohistochemical and chromogenic in situ hybridization study
    J Martin de las Mulas
    Department of Comparative Pathology, Veterinary School, University of Cordoba, Cordoba, Spain
    Breast Cancer Res Treat 80:363-7. 2003
    ..Canine mammary carcinoma would be a suitable natural model of that subset of human breast carcinomas with HER-2 protein overexpression without gene amplification...
  96. ncbi Canine mammary gland tumors
    Karin Sorenmo
    University of Pennsylvania, School of Veterinary Medicine, Department of Clinical Studies, 3900 Delancey Street, Philadelphia, PA 19104, USA
    Vet Clin North Am Small Anim Pract 33:573-96. 2003
    ....
  97. ncbi The role of the epidermal growth factor receptor family in mammary tumorigenesis and metastasis
    H Kim
    Institute for Molecular Biology and Biotechnology, McMaster University, Hamilton, Ontario, L8S 4K1, Canada
    Exp Cell Res 253:78-87. 1999
    ..Although there are many molecular steps that appear to drive each stage of tumor development, the EGF receptor family appears to play a causal role in the progression to a transformed phenotype...
  98. ncbi Effect of spaying and timing of spaying on survival of dogs with mammary carcinoma
    K U Sorenmo
    Department of Clinical Studies and Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia 19104 6010, USA
    J Vet Intern Med 14:266-70. 2000
    ..55; 95% CI .32-.93; P = .03). This study reveals ovariohysterectomy to be an effective adjunct to tumor removal in dogs with mammary gland carcinoma and that the timing of ovariohysterectomy is important in influencing survival...
  99. ncbi Expression of different phenotypes in cell lines from canine mammary spindle-cell tumours and osteosarcomas indicating a pluripotent mammary stem cell origin
    E Hellmen
    Department of Pathology, Swedish University of Agricultural Sciences SLU, Uppsala
    Breast Cancer Res Treat 61:197-210. 2000
    ..By in situ hybridization with genomic DNA we could verify that all formed tumours but one were of canine origin. Our results support the hypothesis that canine mammary tumours are derived from pluripotent stem cells...
  100. ncbi Prognostic value of histologic stage and proliferative activity in canine malignant mammary tumors
    Giuseppe Sarli
    Department of Veterinary Public Health and Animal Pathology, Division of Veterinary Pathology, Via Tolara di Sopra 50 40064 Ozzano Emilia, Bologna, Italy
    J Vet Diagn Invest 14:25-34. 2002
    ..AgNOR index for 1-year survival and histologic stage for 2-year survival were the most significant parameters influencing survival, as determined by multiple nonlinear logistic regression...
  101. pmc Grb2 and Shc adapter proteins play distinct roles in Neu (ErbB-2)-induced mammary tumorigenesis: implications for human breast cancer
    D Dankort
    Department of Biology, Institute for Molecular Biology and Biotechnology, McMaster University, Hamilton, Ontario, Canada L8S 4K1
    Mol Cell Biol 21:1540-51. 2001
    ..These observations argue that Grb2 and Shc play important and distinct roles in ErbB-2/Neu-induced mammary tumorigenesis and metastasis...

Research Grants68

  1. Apoptotic Mechanisms of Tocotrienols in Mammary Cancer
    Paul Sylvester; Fiscal Year: 2004
    ..Although caspase-8 activation is associated with death receptor signaling, the exact receptor/ligand signaling mechanism(s) mediating tocotrienol-induced caspase-8 activation has not been determined. ..
  2. P53 AND MOUSE MAMMARY TUMORIGENESIS
    Daniel Medina; Fiscal Year: 2004
    ..In summary, this model allows one to analyze the biological, genetic and molecular consequences of p53 gene deletion in the in situ mammary gland by taking advantage of transplantation methods. ..
  3. MECHANISMS OF THE HORMONAL PREVENTION OF BREAST CANCER
    Daniel Medina; Fiscal Year: 2006
    ..The molecular understanding of the fundamental biological events involved in hormone-induced growth and differentiation will provide a rationale for developing new approaches for preventing human breast cancer. ..
  4. BIO-ACTIVATION OF VITAMIN D IN MAMMARY GLAND
    JoEllen Welsh; Fiscal Year: 2004
    ..These studies will provide important information regarding the expression and function of the vitamin D signaling pathway in normal mammary gland, which might have implications for breast cancer prevention. ..
  5. Characterization of the MMTV Receptor
    Susan Ross; Fiscal Year: 2006
    ..Together, these two approaches will allow us to better understand how viruses utilize the biology of their host for propagation and how MMTV specifically induces breast cancer in mice. ..
  6. Genistein Impriting Against Prostate Cancer
    CORAL LAMARTINIERE; Fiscal Year: 2003
    ..We propose this in a dietary model at "physiological concentrations." ..
  7. Genetics of Susceptibility to MMTV-Induced Mammary Tumor
    Susan Ross; Fiscal Year: 2006
    ..The results obtained from these studies will greatly increase our understanding of the genetic mechanisms which viruses use to infect their hosts and how genetic resistance to such viruses in the hosts occurs. ..
  8. Role of ITAM repeats in virus-induced breast cancer
    Susan R Ross; Fiscal Year: 2010
    ..These studies are of potential importance in developing new treatment paradigms for breast and other cancers, especially those associated with viruses that encode proteins that activate ITAM-mediated signaling. ..
  9. In Utero Mammary Cancer Risk with Resveratrol and TCDD
    CORAL LAMARTINIERE; Fiscal Year: 2008
    ..Programming breast cancer chemoprevention from in utero exposure to a nutritional agent would be a novel breakthrough for women's health. [unreadable] [unreadable] [unreadable]..
  10. In Utero TCDD Programming for Mammary Cancer
    CORAL LAMARTINIERE; Fiscal Year: 2005
    ..abstract_text> ..
  11. PRECLINICAL MODELS OF BREAST CANCER
    Robert Cardiff; Fiscal Year: 2003
    ..The theme of the workshop is "High Throughput Phenotyping: From Mouse to Molecule in One Day!" It will allow the student to examine and compare the best and fastest phenotyping technology currently available. ..
  12. 25TH IABCR CONGRESS CONFERENCE: PERSONALIZED BREAST CANCER THERAPY
    Robert Cardiff; Fiscal Year: 2006
    ..The session will also include a plenary lecture from Dr. A Ullrich who pioneered the concept of targeting the HER2 oncogene in the treatment of breast cancer. [unreadable] [unreadable] [unreadable] [unreadable]..
  13. BIOLOGY OF NEOPLASTIC TRANSFORMATION IN BREAST CANCER
    Robert Cardiff; Fiscal Year: 2005
    ..The goal of this project is to develop a well-characterized model for breast cancer development and to dissect the molecular pathways involved in tumor formation. ..
  14. Role of Kupffer Cell in Hepatic Carcinogenesis
    James Klaunig; Fiscal Year: 2009
    ..These studies will further our understanding into the mechanisms of the development and progression of human liver cancer with potential application to prevention and therapy. ..
  15. Retroviral interactions with toll-like receptors
    Susan Ross; Fiscal Year: 2006
    ..The work proposed here represents the first characterization of viral PAMPs as well as the first structural studies of the extracellular domains of TLR2 and TLR4. ..
  16. POPULATION RISK MODEL FOR ALPHA-INDUCED BONE NEOPLASMS
    RAY LLOYD; Fiscal Year: 2005
    ..7) To develop a general risk model for alpha-induced neoplasms. For this, data in human and experimental studies on radium will be used as a basis for extrapolation to other alpha-emitting nuclides. ..
  17. Antiestrogenic Effects on Tumor Angiogenesis
    Kimberly Blackwell; Fiscal Year: 2006
    ..The results of this project will have profound implications, especially as clinicians begin to use the newer estrogen receptor modulating drugs for the prevention and treatment of breast cancer. ..
  18. 2,3,7,8,--TCDD Effects on the Estrogenic Responses
    Stephen Safe; Fiscal Year: 2006
    ..The proposed Aims will address important mechanistic considerations on IDRE-independent inhibitory AhR-ERa crosstalk and pathways critical for inhibition of mammary tumor growth by SAhRMs. ..
  19. Wnt signaling in mammary development and cancer
    Anthony Brown; Fiscal Year: 2006
    ..Since aberrant Wnt expression and signaling is associated with human breast cancer, the results may be applicable to future strategies of Wnt receptor modulation as a means of therapeutic intervention. ..
  20. IGF-1 Receptor Signaling in Mammary Gland Development
    Darryl Hadsell; Fiscal Year: 2006
    ..abstract_text> ..
  21. P53-dependent responses to toxicants in parous and nulliparous breast
    D Joseph Jerry; Fiscal Year: 2010
    ....
  22. TOXICOLOGY OF ENVIRONMENT CONTAMINANTS
    Stephen Safe; Fiscal Year: 2007
    ..The proposed training program will continue to provide trainees with a challenging academic and research environment that will prepare them for future careers in academic, industry and government. ..
  23. Genomic Instability and Etiology of Estrogen Oncogenesis
    Jonathan Li; Fiscal Year: 2007
    ..abstract_text> ..
  24. Timing of dietary exposure and breast cancer risk
    Leena Hilakivi Clarke; Fiscal Year: 2008
    ..This program aims to develop novel means to prevent some breast cancers by dietary modifications that take place during pregnancy and puberty. ..
  25. CSF-1 and c-fms and the Early Endometriotic Lesion
    Rajeshwar Rao Tekmal; Fiscal Year: 2010
    ....
  26. Conference on Tumor Induction and Progression
    Mina Bissell; Fiscal Year: 2005
    ..We need to capture more brilliant minds to enter this area. In this first Keystone meeting on tumor microenvironment, we propose to unravel the excitement and the promise of the field. ..
  27. HETERODIMERIZATION AND ERBB RECEPTOR SIGNALING
    KERMIT CARRAWAY; Fiscal Year: 2001
    ....
  28. Profiling Modifications of p53 by Mass Spectrometry
    D Jerry; Fiscal Year: 2003
    ..Optimized procedures will be applied to human tumors to determine the patterns of post-translational modifications by MALDI-ToF. ..
  29. FUNCTION OF A DUAL SPECIFICITY TRANSCRIPTION FACTOR
    Peter Hurlin; Fiscal Year: 2003
    ..Finally, gene targeting in the mouse will be used to study the biological activities of Mga and the individual roles of its bHLHZip domain and T-domain. ..
  30. 4th International Symposium on Hormonal Carcinogenesis
    Jonathan Li; Fiscal Year: 2003
    ..abstract_text> ..
  31. Chemoprevention of Chemically-Induced Bladder Cancers
    Clinton Grubbs; Fiscal Year: 2004
    ..Depending on the results in the FTI treated rats, additional profiles can be assessed in the celecoxib and esculetin treated animals. ..
  32. HETEROSPECIFIC CELL/CELL INTERACTIONS IN PROSTATE GROWTH
    Gerald Cunha; Fiscal Year: 2001
    ..Concepts derived from the analysis of basic cellular mechanisms of prostatic growth will be applied to the pathogenesis of BPH. ..
  33. WILD DERIVED MOUSE STOCKS--NEW MODELS FOR AGING RESEARCH
    Richard Miller; Fiscal Year: 2004
    ....
  34. Prevention of Urinary Bladder Carcinogenesis in Mice
    Clinton Grubbs; Fiscal Year: 2005
    ..Examination of altered RNA levels in cancers and preneoplastic lesions in an animal model will facilitate the development of relevant surrogate biomarkers for cancer chemoprevention studies (one of the stated goals of this RFA). ..
  35. Antiviral/Antitumor Roles of Ganoderma Lucidum Spores
    Rui Liu; Fiscal Year: 2005
    ....
  36. Opioid and Breast Cancer Growth and Metastasis
    Kalpna Gupta; Fiscal Year: 2009
    ..If our hypothesis are true, this Proposal may lead to the development of novel therapeutics for breast cancer treatment and to altered clinical decision making in treating pain in cancer patients. ..
  37. 5th International Symposium on Hormonal Carcinogenesis
    Jonathan Li; Fiscal Year: 2006
    ..Area 4: Hormone Dependency and Independency. e) In prostate, breast and uterine cancer, Session 6. As in the past, a book will be published of the presentations. [unreadable] [unreadable] [unreadable] [unreadable]..
  38. Detection of Live Fibers in Injured Spinal Cord
    Mehmet Bilgen; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  39. Regulation of Vascular Function by Progesterone Receptor
    Luisa Iruela Arispe; Fiscal Year: 2007
    ..abstract_text> ..
  40. CELL CELL INTERACTIONS IN PROSTATE CANCER
    Gerald Cunha; Fiscal Year: 2001
    ..These studies should define critical cellular and molecular pathways in both normal and tumorigenic growth of the prostate, and should provide the biological basis of new therapeutic strategies. ..
  41. Ocular Surface Protection by Muc4/Sialomucin Complex
    KERMIT CARRAWAY; Fiscal Year: 2007
    ..These combined studies should help to provide us with a more complete picture of the functions of Muc4/SMC at the ocular surface and insights into the roles of this mucin in ocular surface diseases and aberrations. ..
  42. Role of the chronic inflammatory mediator NO in early mammary tumorigenesis
    LESLEY ELLIES; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  43. ALKYL PCDFS--INHIBITION OF MAMMARY CANCER
    Stephen Safe; Fiscal Year: 2001
    ..Thus the proposed studies will define a new mechanism-based class of antiestrogens that can be used alone or in combination with tamoxifen for treatment of breast and endometrial cancer. ..
  44. Function of Muc4 in Mammary Epithelia and Tumors
    KERMIT CARRAWAY; Fiscal Year: 2009
    ..Providing evidence for MUC4 contributions to breast tumor progression is a prelude to developing methods for therapeutic targeting of this molecule. ..
  45. ROLE OF STROMA IN MAMMARY GLAND CELL PROLIFERATION
    SANDRA HASLAM; Fiscal Year: 2007
    ..The long-term goal of this proposal is the delineation of the mechanisms of P-dependent growth regulation in the adult normal mammary gland that may lead to novel strategies for the prevention and treatment of breast cancer. ..
  46. GENETICS OF AGE SENSITIVE TRAITS IN MICE
    Richard Miller; Fiscal Year: 2003
    ..At best, the program may permit the localization of loci that influence multiple age-sensitive domains and are thus plausible candidates for genes that regulate the rate of aging per se. ..
  47. Functions of HER2/ErbB2 Ligand Sialomucin Complex/Muc4
    KERMIT CARRAWAY; Fiscal Year: 2006
    ..abstract_text> ..
  48. TELOMERE DYSFUNCTION, GENOMIC INSTABILITY AND CANCER
    Steven Artandi; Fiscal Year: 2005
    ..Transplantation experiments using this model will reveal if the effect on tumor biology is a cell autonomous one. ..
  49. CALCIUM RECEPTOR IN MAMMARY DEVELOPMENT AND PHYSIOLOGY
    Joshua VanHouten; Fiscal Year: 2006
    ..This will be accomplished through formal course work and by interactions with the co-sponsor and collaborators. Yale is an ideal training environment, with an abundance of physical and intellectual resources. ..
  50. Colon Cancer Inhibition by a Class of PPARgamma Agonists
    Stephen Safe; Fiscal Year: 2009
    ..The proposed studies will provide mechanistic insights on PPARy-dependent inhibition of colon cancer and identify compounds for future clinical studies. ..
  51. Novel Functions for Telomerase Enzyme Complex in Vivo
    Steven Artandi; Fiscal Year: 2005
    ..Through analysis of a conditional knockout mouse, we will determine the role of endogenous telomerase in cells in culture and in stern/progenitor compartments in vivo. ..
  52. 12th International ISD Conference: Cancer & Development
    Mina Bissell; Fiscal Year: 2002
    ..abstract_text> ..
  53. Interactions of Black Cohosh with Cancer Therapy
    Sara Rockwell; Fiscal Year: 2005
    ..This project will assess these possibilities. The findings will show whether this herb is inactive and harmless, potentially dangerous to breast cancer patients, or of potential value in the treatment of this disease. ..
  54. PROSTATE CELL PROLIFERATION IN CANCER AND AGING
    ANA SOTO; Fiscal Year: 2005
    ..We expect that this research will lead to the development of markers to identify this phenotype, and to the development of specific therapeutic strategies. ..
  55. Early Detection of Lung Cancer via Bi Plane Correlation
    Ehsan Samei; Fiscal Year: 2002
    ..The findings will be used to demonstrate the capability of the approach for improving the detection of lung nodules, and thus the prognosis of lung cancer. ..
  56. Psychosocial modulation of mammary carcinogenesis
    Jason Yee; Fiscal Year: 2008
    ..As such, these studies will also allow an estimation of the proportion of the racial disparity in breast cancer that can be explained by social inequalities. [unreadable] [unreadable] [unreadable] [unreadable]..
  57. GORDON CONFERENCE ON ENVIRONMENTAL ENDOCRINE DISRUPTORS
    ANA SOTO; Fiscal Year: 2002
    ..abstract_text> ..
  58. CHEMOKINE RECEPTORS AND ITP AND HIV THROMBOCYTOPE
    Shahin Rafii; Fiscal Year: 2002
    ..Modulation of chemokine receptors expression by adenoviral vectors overexpressing SDF1, ECDF1 or their receptors may allow for developing therapies to ameliorate thrombocytopenia in vivo. ..
  59. Perinatal xenoestrogen exposure: epigenesis and neoplasia
    ANA SOTO; Fiscal Year: 2007
    ..This will also have a great impact on the way we study risk factors and conduct epidemiological studies; it may even influence public policy about breast cancer prevention. [unreadable] [unreadable] [unreadable] [unreadable]..
  60. Seasonal Plasticity of Brain and Behavior
    Leah Pyter; Fiscal Year: 2005
    ..3) To determine whether photoperiod also affects non-spatial learning and memory tasks. This research will provide insights into the mechanisms of seasonal plasticity of brain and behavior ..
  61. Therapy of thrombocytopenic disorders by chemokines
    Shahin Rafii; Fiscal Year: 2007
    ..being evaluated in phase I clinical trials, would provide the platform for assessing the role of these agents in amelioration and rapid restoration of thrombocytopenia Induced by chemotherapy and irradiation [unreadable] [unreadable]..
  62. A Canine Model For Carcinogenesis and Chemoprevention
    Elizabeth McNiel; Fiscal Year: 2004
    ..This work will establish a paradigm for utilizing spontaneously occurring canine cancer in cancer research, which is our long-term goal. ..
  63. Int5/Aromatase Effect of Breast Estrogen in Neoplasia
    RAJESHWAR TEKMAL; Fiscal Year: 2005
    ..abstract_text> ..
  64. Regulation of breast cancer growth by activation peptide
    Vaclav Vetvicka; Fiscal Year: 2006
    ..The overall goal is to generate a pharmacological agent for breast cancer based on blockage of the autocrine growth factor activity of pCD. ..
  65. Vascular Heterogeneity Determination by Marrow Progenit*
    Shahin Rafii; Fiscal Year: 2006
    ..These studies will lay the foundation for using BM-marrow derived cells for therapeutic cell therapy to enhance organ (i.e. lung, marrow) revascularization. ..
  66. A NOVEL CANCER MODEL--VACCINE ASSOCIATED SARCOMA
    Elizabeth McNiel; Fiscal Year: 2005
    ..I intend to apply the techniques and data acquired from this work to establish a center for animal tumor cytogenetics and genomic to study the role of genetics in the pathogenesis of cancer. ..