animal disease models

Summary

Summary: Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.

Top Publications

  1. ncbi Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation
    M E Gurney
    Department of Cell and Molecular Biology, Northwestern University Medical School, Chicago, IL 60611
    Science 264:1772-5. 1994
  2. ncbi Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction
    Salvatore Oddo
    Department of Neurobiology and Behavior, University of California, Irvine, Irvine, California 92697, USA
    Neuron 39:409-21. 2003
  3. ncbi Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice
    L Mangiarini
    Division of Medical and Molecular Genetics, UMDS, Guy s Hospital, London, United Kingdom
    Cell 87:493-506. 1996
  4. ncbi Of mice and not men: differences between mouse and human immunology
    Javier Mestas
    Center for Immunology and Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697
    J Immunol 172:2731-8. 2004
  5. ncbi A neurotrophic model for stress-related mood disorders
    Ronald S Duman
    Division of Molecular Psychiatry, Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06508, USA
    Biol Psychiatry 59:1116-27. 2006
  6. ncbi A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome
    J Guy
    Wellcome Centre for Cell Biology, Institute of Cell and Molecular Biology, University of Edinburgh, The King s Buildings, Edinburgh, UK
    Nat Genet 27:322-6. 2001
  7. ncbi Deficiency of methyl-CpG binding protein-2 in CNS neurons results in a Rett-like phenotype in mice
    R Z Chen
    The Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    Nat Genet 27:327-31. 2001
  8. ncbi Blockade of microglial activation is neuroprotective in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson disease
    D C Wu
    Department of Neurology, Columbia University, New York, New York 10032, USA
    J Neurosci 22:1763-71. 2002
  9. ncbi Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer's disease
    Alain R Simard
    Laboratory of Molecular Endocrinology, CHUL Research Center and Department of Anatomy and Physiology, Laval University, 2705 Laurier Boul, Quebec G1V 4G2, Canada
    Neuron 49:489-502. 2006
  10. ncbi Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model
    Erik D Roberson
    Gladstone Institute of Neurological Disease, San Francisco, CA 94158, USA
    Science 316:750-4. 2007

Detail Information

Publications282 found, 100 shown here

  1. ncbi Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation
    M E Gurney
    Department of Cell and Molecular Biology, Northwestern University Medical School, Chicago, IL 60611
    Science 264:1772-5. 1994
    ..The results show that dominant, gain-of-function mutations in SOD contribute to the pathogenesis of familial ALS...
  2. ncbi Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction
    Salvatore Oddo
    Department of Neurobiology and Behavior, University of California, Irvine, Irvine, California 92697, USA
    Neuron 39:409-21. 2003
    ....
  3. ncbi Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice
    L Mangiarini
    Division of Medical and Molecular Genetics, UMDS, Guy s Hospital, London, United Kingdom
    Cell 87:493-506. 1996
    ..This transgenic model will greatly assist in an eventual understanding of the molecular pathology of HD and may open the way to the testing of intervention strategies...
  4. ncbi Of mice and not men: differences between mouse and human immunology
    Javier Mestas
    Center for Immunology and Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697
    J Immunol 172:2731-8. 2004
    ..We also provide examples, such as multiple sclerosis and delayed-type hypersensitivity, where complex multicomponent processes differ. Such differences should be taken into account when using mice as preclinical models of human disease...
  5. ncbi A neurotrophic model for stress-related mood disorders
    Ronald S Duman
    Division of Molecular Psychiatry, Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06508, USA
    Biol Psychiatry 59:1116-27. 2006
    ....
  6. ncbi A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome
    J Guy
    Wellcome Centre for Cell Biology, Institute of Cell and Molecular Biology, University of Edinburgh, The King s Buildings, Edinburgh, UK
    Nat Genet 27:322-6. 2001
    ....
  7. ncbi Deficiency of methyl-CpG binding protein-2 in CNS neurons results in a Rett-like phenotype in mice
    R Z Chen
    The Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    Nat Genet 27:327-31. 2001
    ..Mecp2 deficiency in these neurons is sufficient to cause neuronal dysfunction with symptomatic manifestation similar to Rett syndrome...
  8. ncbi Blockade of microglial activation is neuroprotective in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson disease
    D C Wu
    Department of Neurology, Columbia University, New York, New York 10032, USA
    J Neurosci 22:1763-71. 2002
    ..This study demonstrates that microglial-related inflammatory events play a significant role in the MPTP neurotoxic process and suggests that minocycline may be a valuable neuroprotective agent for the treatment of PD...
  9. ncbi Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer's disease
    Alain R Simard
    Laboratory of Molecular Endocrinology, CHUL Research Center and Department of Anatomy and Physiology, Laval University, 2705 Laurier Boul, Quebec G1V 4G2, Canada
    Neuron 49:489-502. 2006
    ..Therapeutic strategies aiming to improve their recruitment could potentially lead to a new powerful tool for the elimination of toxic senile plaques...
  10. ncbi Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model
    Erik D Roberson
    Gladstone Institute of Neurological Disease, San Francisco, CA 94158, USA
    Science 316:750-4. 2007
    ..Thus, tau reduction can block Abeta- and excitotoxin-induced neuronal dysfunction and may represent an effective strategy for treating Alzheimer's disease and related conditions...
  11. pmc Progression to malignancy in the polyoma middle T oncoprotein mouse breast cancer model provides a reliable model for human diseases
    Elaine Y Lin
    Center for Study of Reproductive Biology and Women s Health, Departments of Developmental and Molecular Biology Obstetrics and Gynecology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Am J Pathol 163:2113-26. 2003
    ..An increased leukocytic infiltration was also closely associated with the malignant transition. This study demonstrates that the PyMT mouse model is an excellent one to understand the biology of tumor progression in humans...
  12. pmc Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons
    Makiko Nagai
    Department of Neurology, Columbia University, 710 West 168th Street, New York, New York 10032, USA
    Nat Neurosci 10:615-22. 2007
    ..Identification of the astrocyte-derived soluble factor(s) may have far-reaching implications for ALS from both a pathogenic and therapeutic standpoint...
  13. ncbi The NOD mouse: a model of immune dysregulation
    Mark S Anderson
    Diabetes Center, University of California, San Francisco, California 94143, USA
    Annu Rev Immunol 23:447-85. 2005
    ..The information gained from this highly relevant model of human disease will lead to potential therapies that may alter the development of the disease and its progression in patients with T1D...
  14. ncbi The story of Rett syndrome: from clinic to neurobiology
    Maria Chahrour
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Neuron 56:422-37. 2007
    ..Moreover, deciphering the molecular underpinnings of RTT is likely to contribute to the understanding of the pathogenesis of a broader class of neuropsychiatric disorders...
  15. ncbi Cytokines: accelerators and brakes in the pathogenesis of cerebral malaria
    Nicholas H Hunt
    Department of Pathology, D06, University of Sydney, Sydney, NSW 2006, Australia
    Trends Immunol 24:491-9. 2003
    ..Furthermore, recent evidence has emerged indicating that cytokines might influence biochemical pathways in the brain that, in turn, could determine the outcome of CM...
  16. ncbi Somatic activation of the K-ras oncogene causes early onset lung cancer in mice
    L Johnson
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Nature 410:1111-6. 2001
    ..This approach has several advantages over traditional transgenic strategies, including that it more closely recapitulates spontaneous oncogene activation as seen in human cancers...
  17. ncbi Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease
    F Bard
    Elan Pharmaceuticals, 800 Gateway Boulevard, South San Francisco, California 94080, USA
    Nat Med 6:916-9. 2000
    ....
  18. ncbi CNS plasticity and assessment of forelimb sensorimotor outcome in unilateral rat models of stroke, cortical ablation, parkinsonism and spinal cord injury
    T Schallert
    Department of Psychology and Institute for Neuroscience, University of Texas at Austin, Mezes 330, Austin, TX 78712, USA
    Neuropharmacology 39:777-87. 2000
    ..OP-1 showed a beneficial effect on limb use asymmetry in the cylinder test...
  19. ncbi Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila
    J S Steffan
    Department of Psychiatry and Human Behavior, Gillespie 2121, University of California, Irvine, California 92697, USA
    Nature 413:739-43. 2001
    ..These findings raise the possibility that therapy with HDAC inhibitors may slow or prevent the progressive neurodegeneration seen in Huntington's disease and other polyglutamine-repeat diseases, even after the onset of symptoms...
  20. ncbi Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice
    S S Moy
    North Carolina STAART Center for Autism Research, Neurodevelopmental Disorders Research Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
    Genes Brain Behav 3:287-302. 2004
    ..This new standardized procedure to quantitate sociability and preference for social novelty in mice provides a method to assess tendencies for social avoidance in mouse models of autism...
  21. ncbi Neuronal alpha-synucleinopathy with severe movement disorder in mice expressing A53T human alpha-synuclein
    Benoit I Giasson
    Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, 3600 Spruce Street, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Neuron 34:521-33. 2002
    ..These mice demonstrate that A53T alpha-synuclein leads to the formation of toxic filamentous alpha-synuclein neuronal inclusions that cause neurodegeneration...
  22. pmc Early-onset behavioral and synaptic deficits in a mouse model of Alzheimer's disease
    J Steven Jacobsen
    Discovery Neuroscience, Wyeth Research, CN 8000, Princeton, NJ 08543, USA
    Proc Natl Acad Sci U S A 103:5161-6. 2006
    ..Overall, these data show that the perforant path input from the entorhinal cortex to the DG is compromised both structurally and functionally, and this pathology is manifested in memory defects long before significant plaque deposition...
  23. pmc Reversing established sepsis with antagonists of endogenous high-mobility group box 1
    Huan Yang
    Laboratory of Biomedical Science, North Shore Long Island Jewish Research Institute, 350 Community Drive, Manhasset, NY 11030, USA
    Proc Natl Acad Sci U S A 101:296-301. 2004
    ..These observations demonstrate that specific inhibition of endogenous HMGB1 therapeutically reverses lethality of established sepsis indicating that HMGB1 inhibitors can be administered in a clinically relevant time frame...
  24. ncbi Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells
    A S Plump
    Laboratory of Biochemical Genetics and Metabolism, The Rockefeller University, New York, New York 10021 6399
    Cell 71:343-53. 1992
    ..apoE-deficient mice are a promising small animal model to help understand the role of apoE in vivo and the genetic and environmental determinants of atherosclerosis...
  25. ncbi Understanding pathogenesis and therapy of multiple sclerosis via animal models: 70 years of merits and culprits in experimental autoimmune encephalomyelitis research
    Ralf Gold
    Institute for Multiple Sclerosis Research, Department of Experimental and Clinical Neuroimmunology, University of Goettingen and Gemeinnützige Hertie Stiftung, Gottingen, Germany
    Brain 129:1953-71. 2006
    ....
  26. ncbi Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice
    S E Artandi
    Department of Adult Oncology, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Nature 406:641-5. 2000
    ..Our data suggest a model in which telomere dysfunction brought about by continual epithelial renewal during life generates the massive ploidy changes associated with the development of epithelial cancers...
  27. pmc Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology
    C Sturchler-Pierrat
    Novartis Pharma, Inc, Basel, Switzerland
    Proc Natl Acad Sci U S A 94:13287-92. 1997
    ..These mice resemble major features of AD pathology and suggest a central role of A beta in the pathogenesis of the disease...
  28. pmc Development of functional human blood and immune systems in NOD/SCID/IL2 receptor {gamma} chain(null) mice
    Fumihiko Ishikawa
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, 44 Binney St, no 770, Boston, MA 02115, USA
    Blood 106:1565-73. 2005
    ..Thus, the NOD/SCID/IL2rgamma(null) newborn system might be an important experimental model to study the human hemato-lymphoid system...
  29. pmc Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, ameliorates motor deficits in a mouse model of Huntington's disease
    Emma Hockly
    Medical and Molecular Genetics, Guy s, King s and St Thomas School of Medicine, King s College London, Eighth Floor Guy s Tower, Guy s Hospital, London SE1 9RT, United Kingdom
    Proc Natl Acad Sci U S A 100:2041-6. 2003
    ..SAHA dramatically improved the motor impairment in R6/2 mice, clearly validating the pursuit of this class of compounds as HD therapeutics...
  30. ncbi Chronic stress induces contrasting patterns of dendritic remodeling in hippocampal and amygdaloid neurons
    Ajai Vyas
    National Centre for Biological Sciences, Tata Institute of Fundamental Research, Bangalore 560065, India
    J Neurosci 22:6810-8. 2002
    ..Thus, stress-induced structural plasticity in amygdala neurons may provide a candidate cellular substrate for affective disorders triggered by chronic stress...
  31. ncbi Paradoxical roles of the immune system during cancer development
    Karin E de Visser
    Department of Molecular Biology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Nat Rev Cancer 6:24-37. 2006
    ....
  32. ncbi Restoration of p53 function leads to tumour regression in vivo
    Andrea Ventura
    Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
    Nature 445:661-5. 2007
    ..These results support efforts to treat human cancers by way of pharmacological reactivation of p53...
  33. ncbi Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease
    Tiago Fleming Outeiro
    Alzheimer s Research Unit, MGH, Harvard Medical School, CNY 114, 16th Street, Charlestown, MA 02129, USA
    Science 317:516-9. 2007
    ..Furthermore, the inhibitors protected against dopaminergic cell death both in vitro and in a Drosophila model of Parkinson's disease. The results suggest a link between neurodegeneration and aging...
  34. ncbi Abundant tau filaments and nonapoptotic neurodegeneration in transgenic mice expressing human P301S tau protein
    Bridget Allen
    Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 2QH, United Kingdom
    J Neurosci 22:9340-51. 2002
    ..No evidence for apoptosis was obtained, despite the extensive colocalization of hyperphosphorylated tau protein with activated MAP kinase family members. The latter may be involved in the hyperphosphorylation of tau...
  35. ncbi Characterization of amyloid deposition in the APPswe/PS1dE9 mouse model of Alzheimer disease
    Monica Garcia-Alloza
    Alzheimer Research Unit, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, 114 16th Street, Charlestown, MA 02129, USA
    Neurobiol Dis 24:516-24. 2006
    ....
  36. ncbi Osteoarthritis cartilage histopathology: grading and staging
    K P H Pritzker
    Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Canada
    Osteoarthritis Cartilage 14:13-29. 2006
    ..Our objective was to devise a more useful method to assess OA histopathology that would have wide application for clinical and experimental OA assessment and would become recognized as the standard method...
  37. pmc Dendritic spine abnormalities in amyloid precursor protein transgenic mice demonstrated by gene transfer and intravital multiphoton microscopy
    Tara L Spires
    Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Neurosci 25:7278-87. 2005
    ..Decreased spine density will likely contribute to altered neural system function and behavioral impairments observed in Tg2576 mice...
  38. pmc The hematopoietic factor G-CSF is a neuronal ligand that counteracts programmed cell death and drives neurogenesis
    Armin Schneider
    Axaron Bioscience AG, Heidelberg, Germany
    J Clin Invest 115:2083-98. 2005
    ..We therefore propose G-CSF as a potential new drug for stroke and neurodegenerative diseases...
  39. pmc Murine model for dengue virus-induced lethal disease with increased vascular permeability
    Sujan Shresta
    Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA
    J Virol 80:10208-17. 2006
    ..This report represents a significant advance in animal models for severe DEN disease, and it begins to provide mechanistic insights into DEN-induced disease in vivo...
  40. ncbi A muscleblind knockout model for myotonic dystrophy
    Rahul N Kanadia
    Department of Molecular Genetics and Microbiology, Powell Gene Therapy Center, Gainesville, FL 32610, USA
    Science 302:1978-80. 2003
    ..Our results support the hypothesis that manifestations of DM can result from sequestration of specific RNA binding proteins by a repetitive element expansion in a mutant RNA...
  41. ncbi HPRT-deficient (Lesch-Nyhan) mouse embryos derived from germline colonization by cultured cells
    M Hooper
    Nature 326:292-5. 1987
    ..In human males, HPRT deficiency causes Lesch-Nyhan syndrome, which is characterized by mental retardation and self-mutilation...
  42. pmc Dissecting the pathological effects of human Abeta40 and Abeta42 in Drosophila: a potential model for Alzheimer's disease
    Koichi Iijima
    Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA
    Proc Natl Acad Sci U S A 101:6623-8. 2004
    ..Moreover, Drosophila may serve as a model for facilitating the understanding of molecular mechanisms underlying Abeta toxicity and the discovery of novel therapeutic targets for AD...
  43. ncbi Oncogenic pathway signatures in human cancers as a guide to targeted therapies
    Andrea H Bild
    Institute for Genome Sciences and Policy, Duke University, Durham, North Carolina 27708, USA
    Nature 439:353-7. 2006
    ..Linking pathway deregulation with sensitivity to therapeutics that target components of the pathway provides an opportunity to make use of these oncogenic pathway signatures to guide the use of targeted therapeutics...
  44. ncbi The human centromeric survival motor neuron gene (SMN2) rescues embryonic lethality in Smn(-/-) mice and results in a mouse with spinal muscular atrophy
    U R Monani
    Departments of Neurology, College of Medicine, Ohio State University, Columbus, OH 43210, USA
    Hum Mol Genet 9:333-9. 2000
    ..These results show that SMA is caused by insufficient SMN production by the SMN2 gene and that increased expression of the SMN2 gene may provide a strategy for treating SMA patients...
  45. pmc Abeta42-driven cerebral amyloidosis in transgenic mice reveals early and robust pathology
    Rebecca Radde
    Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, Otfried Muller Strasse 27, D 72076 Tubingen, Germany
    EMBO Rep 7:940-6. 2006
    ....
  46. ncbi Activation of p38 mitogen-activated protein kinase in spinal microglia is a critical link in inflammation-induced spinal pain processing
    Camilla I Svensson
    Department of Anesthesiology, University of California, San Diego, La Jolla, California, USA
    J Neurochem 86:1534-44. 2003
    ..Taken together, these results indicate that spinal p38 MAPK is involved in inflammation-induced pain and that activated spinal microglia play a direct role in spinal nociceptive processing...
  47. ncbi Anti-TNF alpha therapy of rheumatoid arthritis: what have we learned?
    M Feldmann
    Kennedy Institute of Rheumatology Division, Imperial College School of Medicine, 1 Aspenlea Road, London W6 8LH, United Kingdom
    Annu Rev Immunol 19:163-96. 2001
    ..Infliximab (a mAB), and etanercept (a sTNF-R-Fc fusion protein) have been approved by regulatory authorities in the United States and Europe for treating RA, and they represent a significant new addition to available therapeutic options...
  48. ncbi A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease
    D Morgan
    Department of Pharmacology, University of South Florida, Tampa 33612, USA
    Nature 408:982-5. 2000
    ..The A beta-vaccinated mice also had a partial reduction in amyloid burden at the end of the study. This therapeutic approach may thus prevent and, possibly, treat Alzheimer's dementia...
  49. ncbi Arthritis critically dependent on innate immune system players
    Hong Ji
    Section on Immunology and Immunogenetics, Joslin Diabetes Center, Boston, MA 02215, USA
    Immunity 16:157-68. 2002
    ..We suggest that autoimmune disease, even one that is organ specific, can occur when mobilization of an adaptive immune response results in runaway activation of the innate response...
  50. ncbi Pain related behaviour in two models of osteoarthritis in the rat knee
    Janet Fernihough
    Novartis Institute for Medical Sciences, 5 Gower Place, London WCE 6BS, UK
    Pain 112:83-93. 2004
    ..Gabapentin varied in its ability to reverse both hyperalgesia and allodynia. The iodoacetate model provides a basis for studies on the mechanisms of pain in OA, and for development of novel therapeutic analgesics...
  51. ncbi Transgenic mice with a rhodopsin mutation (Pro23His): a mouse model of autosomal dominant retinitis pigmentosa
    J E Olsson
    Berman Gund Laboratory for the Study of Retinal Degenerations, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston 02114
    Neuron 9:815-30. 1992
    ..Our findings help to establish the pathogenicity of mutant human P23H rod opsin and suggest that overexpression of wild-type human rod opsin leads to a remarkably similar photoreceptor degeneration...
  52. ncbi Time course of early motor and neuropathological anomalies in a knock-in mouse model of Huntington's disease with 140 CAG repeats
    Liliana B Menalled
    Department of Neurology, University of California at Los Angeles, Los Angeles, California 90095, USA
    J Comp Neurol 465:11-26. 2003
    ..Because of their early behavioral anomalies and regionally specific pathology, these mice provide a powerful tool with which to evaluate the effectiveness of new therapies and to study the mechanisms involved in the neuropathology of HD...
  53. ncbi Hypothermia in animal models of acute ischaemic stroke: a systematic review and meta-analysis
    H Bart van der Worp
    Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Centre, Utrecht, The Netherlands
    Brain 130:3063-74. 2007
    ..Large randomized clinical trials testing the effect of hypothermia in patients with acute ischaemic stroke are warranted...
  54. ncbi Revascularization of ischemic tissues by PlGF treatment, and inhibition of tumor angiogenesis, arthritis and atherosclerosis by anti-Flt1
    Aernout Luttun
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, University of Leuven, Leuven, Belgium
    Nat Med 8:831-40. 2002
    ..Thus, PlGF and Flt1 constitute potential candidates for therapeutic modulation of angiogenesis and inflammation...
  55. pmc Erythropoietin prevents neuronal apoptosis after cerebral ischemia and metabolic stress
    A L Siren
    Max Planck Institute for Experimental Medicine, Georg August University, 37075 Goettingen, Germany
    Proc Natl Acad Sci U S A 98:4044-9. 2001
    ..The neurotrophic actions suggest there may be longer-latency effects as well. Evaluation of EPO, a compound established as clinically safe, as neuroprotective therapy in acute brain injury is further supported...
  56. ncbi Suppression of polyglutamine-mediated neurodegeneration in Drosophila by the molecular chaperone HSP70
    J M Warrick
    Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Nat Genet 23:425-8. 1999
    ..Our studies indicate that HSP70 or related molecular chaperones may provide a means of treating these and other neurodegenerative diseases associated with abnormal protein conformation and toxicity...
  57. ncbi Glucagon-like peptide 1 can directly protect the heart against ischemia/reperfusion injury
    Amal K Bose
    The Hatter Institute for Cardiovascular Studies, University College London Hospital and Medical School, Grafton Way, London WC1E, UK
    Diabetes 54:146-51. 2005
    ..This protection appears to involve activating multiple prosurvival kinases. This finding may represent a new therapeutic potential for this class of drug currently undergoing clinical trials in the treatment of type 2 diabetes...
  58. ncbi Neuroprotective effects of phenylbutyrate in the N171-82Q transgenic mouse model of Huntington's disease
    Gabriella Gardian
    Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York Presbyterian Hospital, New York, New York 10021, USA
    J Biol Chem 280:556-63. 2005
    ....
  59. pmc Rapamycin prevents epilepsy in a mouse model of tuberous sclerosis complex
    Ling Hui Zeng
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    Ann Neurol 63:444-53. 2008
    ..Here, we tested whether rapamycin could prevent or reverse epilepsy, as well as other cellular and molecular brain abnormalities in Tsc1(GFAP)CKO mice...
  60. ncbi Designing mouse behavioral tasks relevant to autistic-like behaviors
    Jacqueline N Crawley
    Mouse Behavioral Phenotyping Laboratory, Neurodevelopmental Disorders Research Center, University of North Carolina, Chapel Hill, North Carolina, USA
    Ment Retard Dev Disabil Res Rev 10:248-58. 2004
    ....
  61. pmc Progression of primary pneumonic plague: a mouse model of infection, pathology, and bacterial transcriptional activity
    Wyndham W Lathem
    Department of Molecular Microbiology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 102:17786-91. 2005
    ..pestis...
  62. pmc Antiretroviral pre-exposure prophylaxis prevents vaginal transmission of HIV-1 in humanized BLT mice
    Paul W Denton
    Department of Internal Medicine, Division of Infectious Diseases, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America
    PLoS Med 5:e16. 2008
    ..Given the importance of this route of transmission, we investigated the susceptibility of humanized mice to intravaginal HIV-1 infection...
  63. ncbi Organ-specific disease provoked by systemic autoimmunity
    V Kouskoff
    Institut de Genetique et de Biologie Moleculaire et Cellulaire CNRS INSERM ULP, Illkirch, France
    Cell 87:811-22. 1996
    ..We suggest that human RA develops by an analogous mechanism...
  64. ncbi Pathology of mouse models of intestinal cancer: consensus report and recommendations
    Gregory P Boivin
    Department of Pathology and Laboratory Medicine, University of Cincinnati and Cincinnati Veterans Affairs Medical Center, Cincinnati, Ohio 45267, USA
    Gastroenterology 124:762-77. 2003
  65. ncbi A mouse model for spinal muscular atrophy
    H M Hsieh-Li
    Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan
    Nat Genet 24:66-70. 2000
    ..Our results demonstrate that SMN2 can partially compensate for lack of SMN1. The variable phenotypes of Smn-/-SMN2 mice reflect those seen in SMA patients, providing a mouse model for this disease...
  66. ncbi DNase expression allows the pathogen group A Streptococcus to escape killing in neutrophil extracellular traps
    John T Buchanan
    Department of Pediatrics, University of California, San Diego, La Jolla, California 92093, USA
    Curr Biol 16:396-400. 2006
    ..The results demonstrate a significant role for NETs in neutrophil-mediated innate immunity, and at the same time identify a novel therapeutic target against invasive GAS infection...
  67. ncbi The relationship between Abeta and memory in the Tg2576 mouse model of Alzheimer's disease
    Marcus A Westerman
    Department of Neurology, Center for Clinical and Molecular Neurobiology, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Neurosci 22:1858-67. 2002
    ..These studies also provide a methodological framework within which to investigate these Abeta assemblies in vivo...
  68. pmc Focal loss of the glutamate transporter EAAT2 in a transgenic rat model of SOD1 mutant-mediated amyotrophic lateral sclerosis (ALS)
    David S Howland
    Department of Molecular Genetics, Wyeth Research, CN8000, Princeton, NJ 08543, USA
    Proc Natl Acad Sci U S A 99:1604-9. 2002
    ..These transgenic rats provide a valuable resource to pursue experimentation and therapeutic development, currently difficult or impossible to perform with existing ALS transgenic mice...
  69. ncbi Interleukin-17 family and IL-17 receptors
    T A Moseley
    Department of Orthopaedic Surgery, Center for Tissue Regeneration and Repair, School of Medicine, University of California, Davis, Sacramento, CA 95817, USA
    Cytokine Growth Factor Rev 14:155-74. 2003
    ..This survey reviews the biological actions of IL-17 signaling in cancers, musculoskeletal tissues, the immune system and other tissues...
  70. pmc Sustained hippocampal IL-1 beta overexpression mediates chronic neuroinflammation and ameliorates Alzheimer plaque pathology
    Solomon S Shaftel
    Department of Neurobiology and Anatomy, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
    J Clin Invest 117:1595-604. 2007
    ..These results demonstrate a possible adaptive role for IL-1 beta-driven neuroinflammation in AD and may help explain recent failures of antiinflammatory therapeutics for this disease...
  71. ncbi Accelerating amyloid-beta fibrillization reduces oligomer levels and functional deficits in Alzheimer disease mouse models
    Irene H Cheng
    Gladstone Institute of Neurological Disease, San Francisco, California 94158, USA
    J Biol Chem 282:23818-28. 2007
    ..Thus, Abeta*56 is a likelier determinant of functional deficits in hAPP mice than fibrillar Abeta deposits. Therapeutic interventions that reduce Abeta fibrils at the cost of augmenting nonfibrillar Abeta assemblies could be harmful...
  72. pmc Smn, the spinal muscular atrophy-determining gene product, modulates axon growth and localization of beta-actin mRNA in growth cones of motoneurons
    Wilfried Rossoll
    Institute for Clinical Neurobiology, University of Wuerzburg, 97080 Wuerzburg, Germany
    J Cell Biol 163:801-12. 2003
    ..Together, these data suggest that a complex of Smn with its binding partner hnRNP R interacts with beta-actin mRNA and translocates to axons and growth cones of motoneurons...
  73. pmc Response of a neuronal model of tuberous sclerosis to mammalian target of rapamycin (mTOR) inhibitors: effects on mTORC1 and Akt signaling lead to improved survival and function
    Lynsey Meikle
    Division of Translational Medicine, Department of Medicine, Brigham and Women s Hospital, Children s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 28:5422-32. 2008
    ..Although caution is appropriate, the results suggest the possibility that rapamycin/RAD001 may have benefit in the treatment of TSC brain disease, including infantile spasms...
  74. ncbi Essential role of neutrophils in the initiation and progression of a murine model of rheumatoid arthritis
    B T Wipke
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 167:1601-8. 2001
    ..These studies have identified a critical role for neutrophils in initiating and maintaining inflammatory processes in the joint...
  75. ncbi Recombinant glucagon-like peptide-1 increases myocardial glucose uptake and improves left ventricular performance in conscious dogs with pacing-induced dilated cardiomyopathy
    Lazaros A Nikolaidis
    Department of Medicine, Allegheny General Hospital, Pittsburgh, PA 15212, USA
    Circulation 110:955-61. 2004
    ....
  76. ncbi Abnormalities of social interactions and home-cage behavior in a mouse model of Rett syndrome
    Paolo Moretti
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Hum Mol Genet 14:205-20. 2005
    ..The study of Mecp2(308/Y) mice will allow the identification of the molecular basis of social impairment in RTT and related autistic spectrum disorders...
  77. pmc Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models
    Antony A Cooper
    School of Biological Sciences, University of Missouri Kansas City, Kansas City, MO 64110, USA
    Science 313:324-8. 2006
    ..Thus, synucleinopathies may result from disruptions in basic cellular functions that interface with the unique biology of particular neurons to make them especially vulnerable...
  78. ncbi The Hdh(Q150/Q150) knock-in mouse model of HD and the R6/2 exon 1 model develop comparable and widespread molecular phenotypes
    Ben Woodman
    Department of Medical and Molecular Genetics, King s College London School of Medicine, London, UK
    Brain Res Bull 72:83-97. 2007
    ..This supports the continued use of the more high-throughput fragment models to identify mechanisms of pathogenesis and for preclinical screening...
  79. ncbi Targeting HIF-1 for cancer therapy
    Gregg L Semenza
    McKusick Nathans Institute of Genetic Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 3914, USA
    Nat Rev Cancer 3:721-32. 2003
    ..In preclinical studies, inhibition of HIF-1 activity has marked effects on tumour growth. Efforts are underway to identify inhibitors of HIF-1 and to test their efficacy as anticancer therapeutics...
  80. pmc RNA toxicity is a component of ataxin-3 degeneration in Drosophila
    Ling Bo Li
    Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6018, USA
    Nature 453:1107-11. 2008
    ..These studies reveal a role for the RNA in polyQ toxicity, highlighting common components in RNA-based and polyQ-protein-based trinucleotide repeat expansion diseases...
  81. ncbi Gout-associated uric acid crystals activate the NALP3 inflammasome
    Fabio Martinon
    Department of Biochemistry, University of Lausanne, Chemin des Boveresses 155, 1066 Epalinges, Switzerland
    Nature 440:237-41. 2006
    ..These findings provide insight into the molecular processes underlying the inflammatory conditions of gout and pseudogout, and further support a pivotal role of the inflammasome in several autoinflammatory diseases...
  82. ncbi Animal models of Alzheimer's disease and frontotemporal dementia
    Jürgen Götz
    Alzheimer s and Parkinson s Disease Laboratory, Brain and Mind Research Institute, University of Sydney, 100 Mallett Street, Camperdown, NSW 2050, Australia
    Nat Rev Neurosci 9:532-44. 2008
    ..With advanced imaging techniques that can be used in both humans and mice an early, preclinical diagnosis of AD and FTD could be within reach...
  83. ncbi Skeletal and cardiac myopathies in mice lacking utrophin and dystrophin: a model for Duchenne muscular dystrophy
    R M Grady
    Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cell 90:729-38. 1997
    ..Thus, utrophin attenuates the effects of dystrophin deficiency, and the double mutant may provide a useful model for studies of pathogenesis and therapy...
  84. ncbi The development of emphysema in cigarette smoke-exposed mice is strain dependent
    Alexei Guerassimov
    Respiratory Division, Royal Victoria Hospital, Meakins Christie Laboratories, McGill University, Montreal, Quebec, Canada
    Am J Respir Crit Care Med 170:974-80. 2004
    ..The identification of resistant and susceptible strains for the development of emphysema could be useful for genomic studies of emphysema susceptibility in mice and eventually in humans...
  85. pmc MMP-9 supplied by bone marrow-derived cells contributes to skin carcinogenesis
    L M Coussens
    Cancer Research Institute, University of California, San Francisco 94143, USA
    Cell 103:481-90. 2000
    ..Thus, inflammatory cells can be coconspirators in carcinogenesis...
  86. ncbi Mutation of the receptor tyrosine kinase gene Mertk in the retinal dystrophic RCS rat
    P M D'Cruz
    Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305 5120, USA
    Hum Mol Genet 9:645-51. 2000
    ..Our results provide genetic evidence for an essential role of a receptor tyrosine kinase in a specialized form of phagocytosis and suggest a molecular model for ingestion of outer segments by RPE cells...
  87. ncbi Monolayered mesenchymal stem cells repair scarred myocardium after myocardial infarction
    Yoshinori Miyahara
    Department of Regenerative Medicine and Tissue Engineering, National Cardiovascular Center Research Institute, Suita, Osaka, Japan
    Nat Med 12:459-65. 2006
    ..Thus, transplantation of monolayered mesenchymal stem cells may be a new therapeutic strategy for cardiac tissue regeneration...
  88. pmc An aneuploid mouse strain carrying human chromosome 21 with Down syndrome phenotypes
    Aideen O'Doherty
    Department of Neurodegenerative Disease, Institute of Neurology, Queen Square, London WC1N 3BG, UK
    Science 309:2033-7. 2005
    ..Transchromosomic mouse lines such as Tc1 may represent useful genetic tools for dissecting other human aneuploidies...
  89. ncbi Myc-induced T cell leukemia in transgenic zebrafish
    David M Langenau
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Science 299:887-90. 2003
    ..This transgenic model provides a platform for drug screens and for genetic screens aimed at identifying mutations that suppress or enhance c-myc- induced carcinogenesis...
  90. ncbi Murine model of Niemann-Pick C disease: mutation in a cholesterol homeostasis gene
    S K Loftus
    Laboratory of Genetic Disease Research, National Human Genome Research Institute, National Institutes of Health NIH, Bethesda, MD 20892, USA
    Science 277:232-5. 1997
    ..The mouse model may provide an important resource for studying the role of NPC1 in cholesterol homeostasis and neurodegeneration and for assessing the efficacy of new drugs for NP-C disease...
  91. ncbi Development and pharmacological characterization of a rat model of osteoarthritis pain
    James D Pomonis
    Discovery Research, Purdue Pharma, L P, 6 Cedarbrook Drive, Cranbury, NJ 08512, USA
    Pain 114:339-46. 2005
    ..We conclude that the iodoacetate model of OA is a relevant animal model to study pain associated with OA, and can be used to test potential therapeutic agents...
  92. ncbi Glutaminyl cyclase inhibition attenuates pyroglutamate Abeta and Alzheimer's disease-like pathology
    Stephan Schilling
    Probiodrug AG, Weinbergweg 22, 06120 Halle S, Germany
    Nat Med 14:1106-11. 2008
    ..The reduction of brain pE-Abeta by inhibition of glutaminyl cyclase offers a new therapeutic option for the treatment of Alzheimer's disease and provides implications for other amyloidoses, such as familial Danish dementia...
  93. pmc Reversal of experimental pulmonary hypertension by PDGF inhibition
    Ralph Theo Schermuly
    Department of Internal Medicine, Justus Liebig University Giessen, Giessen, Germany
    J Clin Invest 115:2811-21. 2005
    ..This regimen offers a unique novel approach for antire-modeling therapy in progressed pulmonary hypertension...
  94. ncbi Neurological abnormalities in a knock-in mouse model of Huntington's disease
    C H Lin
    Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Hum Mol Genet 10:137-44. 2001
    ..These mice will serve as useful reagents in experiments designed to reveal the molecular nature of neuronal dysfunction underlying HD...
  95. ncbi Induction of influenza type A virus-specific resistance by immunization of mice with a synthetic multiple antigenic peptide vaccine that contains ectodomains of matrix protein 2
    Krystyna Mozdzanowska
    Immunology Program, The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104 4268, USA
    Vaccine 21:2616-26. 2003
    ..Importantly, the protection in M2e-MAP- and infection-immunized mice appeared to be mediated by distinct immune mechanisms. This suggests that stronger protection may be achievable by combining both protective activities...
  96. ncbi Microarray identification of FMRP-associated brain mRNAs and altered mRNA translational profiles in fragile X syndrome
    V Brown
    Howard Hughes Medical Institute, Department of Human Genetics, Department of Pediatrics, Atlanta, GA 30322, USA
    Cell 107:477-87. 2001
    ..We conclude that translational dysregulation of mRNAs normally associated with FMRP may be the proximal cause of fragile X syndrome, and we identify candidate genes relevant to this phenotype...
  97. ncbi A YAC mouse model for Huntington's disease with full-length mutant huntingtin, cytoplasmic toxicity, and selective striatal neurodegeneration
    J G Hodgson
    Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, Canada
    Neuron 23:181-92. 1999
    ..These mice demonstrate that initial neuronal cytoplasmic toxicity is followed by cleavage of htt, nuclear translocation of htt N-terminal fragments, and selective neurodegeneration...
  98. ncbi Molecular basis of human Usher syndrome: deciphering the meshes of the Usher protein network provides insights into the pathomechanisms of the Usher disease
    Jan Reiners
    Institute of Zoology, Department of Cell and Matrix Biology, Johannes Gutenberg University of Mainz, Müllerweg 6, D 55099 Mainz, Germany
    Exp Eye Res 83:97-119. 2006
    ....
  99. ncbi Mouse behavioral assays relevant to the symptoms of autism
    Jacqueline N Crawley
    Laboratory of Behavioral Neuroscience, Intramural Research Program, National Institute of Mental Health, Bethesda, MD 20892 3730 USA
    Brain Pathol 17:448-59. 2007
    ....
  100. pmc Delayed apoptotic cell clearance and lupus-like autoimmunity in mice lacking the c-mer membrane tyrosine kinase
    Philip L Cohen
    Department of Medicine, Division of Rheumatology, University of Pennsylvania, and Philadelphia Veterans Affairs Medical Center, Philadelphia, PA 19104, USA
    J Exp Med 196:135-40. 2002
    ..These mice should be an excellent model for studying the role of apoptotic debris as an immunogenic stimulus for systemic autoimmunity...
  101. ncbi Reactive astrocytes protect tissue and preserve function after spinal cord injury
    Jill R Faulkner
    Department of Neurobiology, University of California, Los Angeles, California 90095 1763, USA
    J Neurosci 24:2143-55. 2004
    ....

Research Grants63

  1. Breakthroughs to advance the in vitro propagation of human noroviruses
    Qiuhong Wang; Fiscal Year: 2010
    ..These include use of germfree pig and calf (only animal disease models for HuNoV) passaged HuNoV GII...
  2. Heterologous abs from llama and chicken egg yolk to prevent rotavirus diarrhea
    Linda J Saif; Fiscal Year: 2010
    ..Saif's lab to learn newer immunologic procedures (flow cytometry, etc) and work with specialized animal disease models (Gn pigs) as well as to enhance analytical skills related to mucosal immunity...
  3. WHOLE SLIDE IMAGING SYSTEM FOR TRANSLATIONAL NEUROSCIENCE
    Jin Moo Lee; Fiscal Year: 2010
    ..This will support research in brain diseases by speeding assessment of therapeutic effects in animal disease models, assisting research collaboration, and allowing scientist to archive and share results...
  4. Functional genetic evolution of human brain and behavior
    Eric J Vallender; Fiscal Year: 2013
    ..generating a better understanding of human neuropsychiatric and addiction disorders and developing better animal disease models. This will concentrate initially on monoamine oxidase A (MAOA)...
  5. Veterinary Summer Scholars in Comparative Medicine
    Bruce K Walcheck; Fiscal Year: 2011
    ..The T35 program faculty study disease processes in humans, spontaneous animal disease models, and experimental animal models...
  6. Pin1 prolyl isomerase regulates endothelial nitric oxide synthase
    Richard C Venema; Fiscal Year: 2013
    ..purified proteins, cultured endothelial cells, intact blood vessel segments, and whole animals including animal disease models. These studies will provide a more complete understanding than currently exists of regulation of eNOS in ..
  7. Veterinary Summer Scholars in Comparative Medicine
    Bruce K Walcheck; Fiscal Year: 2013
    ..The T35 program faculty study disease processes in humans, spontaneous animal disease models, and experimental animal models...
  8. Imaging Cytolytic T Cells in Cancer Patients Using PET Reporter Genes/Reporter Pr
    Sanjiv S Gambhir; Fiscal Year: 2012
    ..PRP) can be used for long-term monitoring of ex-vivo genetically engineered therapeutic cells in small animal disease models and then in human patients...
  9. Fourth International MHE Research Conference
    Maurizio Pacifici; Fiscal Year: 2012
    ..clinical manifestation and orthopaedics, human genetics, developmental biology, heparan sulfate chemistry, animal disease models and related bone diseases, and about 50 participants (including over 3o invited speakers and non-speaking ..
  10. THE ALS GENE FAMILY OF CANDIDA ALBICANS
    Lois L Hoyer; Fiscal Year: 2010
    ..albicans morphological forms, during cell mating, and on fungal cells from various animal disease models. We will also use the antibodies to support our conclusions about the role of Als proteins in C...
  11. The 6th International Leukocyte Signal Transduction Workshop
    Amnon Altman; Fiscal Year: 2011
    ..will bring together scientists working on: i) fundamental aspects of leukocyte signaling pathways;ii) animal disease models and clinical implications of these pathways;and iii) relevant cutting edge technologies...
  12. 2011 Lysosomal Disease Gordon Research Conference
    STEVEN UPSHAW WALKLEY; Fiscal Year: 2011
    ..science disciplines (genetics, biochemistry, cell biology, pathology, development and characterization of animal disease models etc...
  13. Drug Eluting Contact Lenses
    Joseph B Ciolino; Fiscal Year: 2013
    ..under my current mentor Daniel Kohane, an expert in polymer drug delivery, and James Chodosh, an expert in animal disease models. MEEI is a leader in ophthalmic research...
  14. Endogenous Anti-Inflammatory Lipid Mediators, Fish Oil and Post-Operative Atrial
    Dariush Mozaffarian; Fiscal Year: 2013
    ..While there is promising evidence in animal disease models, the metabolism and anti-inflammatory function of MEFAs in humans remain largely unexplored...
  15. 7th International Leukocyte Signal Transduction Conference
    Amnon Altman; Fiscal Year: 2013
    ..will bring together scientists working on fundamental aspects of leukocyte signaling pathways, related animal disease models, and clinical implications of these pathways, who is cutting edge technologies to address fundamental ..
  16. Humanization of a Novel Monoclonal Neutralizing Antibody for Treating Emphysema
    Daniela Nicoleta Petrusca; Fiscal Year: 2012
    ..We have developed a monoclonal antibody to EMAP II that blocks lung emphysema formation and progression in animal disease models. Based on these encouraging results, we are establishing the tools for humanizing and improving this ..
  17. TRAINING PROGRAM IN DEVELOPMENTAL BIOLOGY
    Victoria E Prince; Fiscal Year: 2012
    ..Developmental biology studies at the University of Chicago include the generation of animal disease models, studies of cancer and stem cell biology, as well as research into the underlying basis of birth defects ..
  18. Small-Animal Optical Imaging System
    Simon R Cherry; Fiscal Year: 2012
    ..This provides a powerful platform for characterizing animal disease models and non-invasively determining the efficacy of new diagnostic and therapeutic strategies in preclinical ..
  19. Long Acting Beta Interferon for Treating Multiple Sclerosis - Phase II Continuing
    George Cox; Fiscal Year: 2009
    ..interferon analogs that are significantly more efficacious than a leading commercial beta interferon in animal disease models. The goals of this Phase II continuing renewal proposal are to manufacture the protein under GLP (Good ..
  20. MECHANISM OF ACTION OF HALOFUGINONE AS A NOVEL THERAPEUTIC
    MALCOLM R WHITMAN; Fiscal Year: 2013
    ..preliminary experiments we have found that halofuginone, a small molecule with efficacy in a variety of animal disease models involving fibrosis and angiogenesis, is a potent and specific activator of the AAR...
  21. The 5th International Leukocyte Signal Transduction Workshop
    Amnon Altman; Fiscal Year: 2009
    ..will bring together scientists working on fundamental aspects of leukocyte signaling, and those studying animal disease models and clinical implications of these signaling pathways...
  22. PET/CT for Multidimensional Translational Cardiovascular Research
    JOHN CANTY; Fiscal Year: 2009
    ..The combined institutional expertise in large animal disease models including hibernating myocardium, coronary disease, cerebrovasular disease and ischemic cardiomyopathy ..
  23. Long-Acting IFN-gamma for Treating Immunodeficiencies
    MARY ROSENDAHL; Fiscal Year: 2005
    ..processes to produce sufficient quantities of the modified interferon-gamma proteins for testing in animal disease models. The improved characteristics of the novel interferon-gamma proteins should reduce the amount of ..
  24. CROSSLINKED LIPOSOMES AS PARTICULATE DRUG CARRIERS
    Moo Cho; Fiscal Year: 1992
    ..include determination of pharmacokinetic disposition of the drug molecules entrapped in the liposomes developed in the present project at the (sub)cellular as well as organ level in animals and efficacy studies in animal disease models.
  25. LONG-ACTING BETA INTERFERON FOR MULTIPLE SCLEROSIS
    George Cox; Fiscal Year: 2001
    ..processes to produce sufficient quantities of the modified beta-interferon proteins for testing in animal disease models. The improved characteristics of the novel beta-interferon proteins should reduce the amount of beta- ..
  26. In vivo RNAi nanoparticle cancer gene function reagent
    Martin Woodle; Fiscal Year: 2009
    ..has been confined largely to cell culture studies, with limited methods for in vivo administration in animal disease models such as NSCLC xenograft tumor models, and none available as a research reagent...
  27. A Unified Reporter Gene for Multi-Modality Imaging
    Jianghong Rao; Fiscal Year: 2005
    ..system should find wide applications in biology from in vivo cell trafficking, tumor metastasis, small animal disease models, transgenic mice, drug screenings in mice, to in vivo gene function and regulation study.
  28. The Fourth International Leukocyte Signal Transduction Workshop: Clinical Implica
    Amnon Altman; Fiscal Year: 2007
    ..scientists working on[unreadable] fundamental aspects of leukocyte signaling and those studying relevant animal disease models and clinical[unreadable] implications of these signaling pathways...
  29. High-resolution tomography for small animal imaging
    CHARLES GARY; Fiscal Year: 2007
    ..will be a table-top computerized tomographic imaging system for use in research laboratories using small animal disease models with per frame exposure times of a few seconds...
  30. CYTOKINE CONJUGATES FOR TREATING THROMBOCYTOPENIA
    George Cox; Fiscal Year: 2000
    ..develop manufacturing processes to produce sufficient quantities of the modified proteins for testing in animal disease models. The improved characteristics of the novel proteins will reduce the amount of protein required per patient,..
  31. INTERFERON CONJUGATES FOR CANCER AND VIRAL DISEASES
    George Cox; Fiscal Year: 1999
    ..develop manufacturing processes to produce sufficient quantities of the modified proteins for testing in animal disease models. The improved characteristics of the novel proteins will reduce the amount of protein required per patient,..
  32. COLD SPRING HARBOR LABORATORY CONFERENCE ON GENE THERAPY
    TERRI GRODZICKER; Fiscal Year: 2000
    ..stable and efficient transplantation of genetically modified cells, the development and study of relevant animal disease models and the design, implementation and results of human clinical trials...
  33. BIOCHEMISTRY AND FUNCTION OF NOVEL MONOKINES
    Barbara Sherry; Fiscal Year: 2002
    ..to many inflammatory stimuli, and that there is differential control of these molecules in several animal disease models. This control is critical because inflammatory reactions that are disproportionate to the magnitude of the ..
  34. ASN Workshop "In Vivo MR Tracking of Stem Cells in the CNS" (R13)
    JEFF BULTE; Fiscal Year: 2005
    ..pursued as a very active research area over the last decade and a remarkable progress has been obtained in animal disease models. To further develop cell-based therapies into the clinic, noninvasive cellular imaging techniques are ..
  35. High-resolution tomography for small animal imaging
    CHARLES GARY; Fiscal Year: 2005
    ..will be a table-top computerized tomographic imaging system for use in research laboratories using small animal disease models. This technology will have possibly the finest resolution of any in-vivo imaging modality and the ability ..
  36. GENETICALLY IDENTICAL RABBITS
    JAMES VITALE; Fiscal Year: 1992
    ..decade, these animals could capture a share of the potentially lucrative market in genetically engineered animal disease models. The optimized protocol will be applied to Watanabe heritable hyperlipidemic (WHHL) rabbits, the only ..
  37. GENETICALLY IDENTICAL RABBITS
    JAMES VITALE; Fiscal Year: 1991
    ..decade, these animals could capture a share of the potentially lucrative market in genetically engineered animal disease models. The optimized protocol will be applied to Watanabe heritable hyperlipidemic (WHHL) rabbits, the only ..
  38. Electroporation-Mediated Gene Therapy with IFN-b for MS
    MAIDA DE LAS ALAS; Fiscal Year: 2002
    ..These findings will provide guidance for future Phase II studies in large animal disease models, and perhaps humans.
  39. Developing animal models for diseases using RNAi
    Zuoshang Xu; Fiscal Year: 2005
    ..Therefore, whether RNAi can serve as an alternative to gene knockout technology to generate animal disease models and to investigate molecular pathways in vivo is unclear...
  40. Long Acting VEGF Inhibitor for Treating RA
    MARY ROSENDAHL; Fiscal Year: 2004
    ..During Phase II, we develop a cost effective manufacturing process and produce sufficient quantities of PEGylated recombinant sFlt-1 for testing in animal disease models and biochemical characterization.
  41. NOVEL METHODS FOR PREPARATION OF CONDENSED PARTICLES
    Vladimir Trubetskoy; Fiscal Year: 2001
    ..reporter genes into cells in vitro and in vivo and subsequently to deliver therapeutic genes into small animal disease models. We have obtained preliminary data on in vitro and in vivo gene delivery using these particles...
  42. Peptide Inhibitor For Alzheimer's Disease Therapy
    YAO ZHONG LIN; Fiscal Year: 2004
    ..studying and manipulating a wide range of intracellular processes, both in vitro and in vivo, including animal disease models. In Specific Aim 1, we will examine whether imported Bsecretase substrate peptides can inhibit the ..
  43. PLACENTAL PROTEIN 14 AS A UNIQUE IMMUNOREGULATOR
    MARK TYKOCINSKI; Fiscal Year: 2005
    ..by PP14; and 3) to design recombinant derivatives of PP14 with enhanced functions, and to explore their therapeutic use in autoimmune and alloimmune animal disease models. The proposed studies combine basic and applied features.
  44. PHAGOCYTE RESOLVING METABOLISM
    Charles Serhan; Fiscal Year: 2009
    ..abstract_text> ..
  45. Plasminogen activators and cerebral ischemic injury
    William M Armstead; Fiscal Year: 2010
    ....
  46. Accelerated arthritis in E and P selectin deficient mice
    Jeffrey Ruth; Fiscal Year: 2007
    ..While common dogma suggests IL-1beta regulates selectins, this study proposes the novel hypothesis that in vivo E- and P-selectins regulate IL-1beta production and CIA development. [unreadable] [unreadable] [unreadable]..
  47. POTASSIUM CHANNELS AND CEREBRAL HEMODYNAMICS AFTER BRAIN
    William Armstead; Fiscal Year: 2005
    ..These studies may lead to therapies for brain injured children. ..
  48. Initiating Events in AMD: An Animal Model for the Human Disease
    Joe Hollyfield; Fiscal Year: 2007
    ..A new model for AMD in the mouse will be an important a new resource for use in the preclinical testing of therapeutics designed to prevent or limit the progression of AMD. ..
  49. Mechanics of Head Impact in Infants
    Brittany Coats; Fiscal Year: 2004
    ..abstract not provided ..
  50. RUNX-fusion Target Genes in Normal and Leukemic Hematopoiesis
    JAMES MULLOY; Fiscal Year: 2007
    ..Understanding the modulation of the self-renewal process by these fusion proteins could give insight into the normal mechanisms of self-renewal employed by the stem cell. [unreadable] [unreadable]..
  51. MULTI-PHOTON CONFOCAL MICROSCOPE SYSTEM
    Janos Peti Peterdi; Fiscal Year: 2008
    ..This multi-photon core is also critically needed for the USC Diabetes Research Center and the Clinical and Translational Science Institute, both being established pending PHS grants. [unreadable] [unreadable] [unreadable]..
  52. A Mitochondrial Etiology of Autism
    Douglas C Wallace; Fiscal Year: 2010
    ..If mitochondrial defects are found, selected patients will be tested using non-invasive biophysical and biochemical tools to determine if they manifest a functional mitochondrial defect. ..
  53. DOPAMINERGIC AND MUSCARINIC SIGNALING IN THE STRIATUM
    DALTON SURMEIER; Fiscal Year: 2007
    ....
  54. LINKAGE & ASSOCIATION IN OBSESSIVE-COMPULSIVE DISORDER
    Marco Grados; Fiscal Year: 2006
    ..Based on results from initial analyses and developing collaborations with other research groups future research projects, such as a genome-wide screen of OCD, are considered. ..
  55. CALCIUM AND THE PATHOPHYSIOLOGY OF THE ADULT HEART CELL
    ROBERT HAWORTH; Fiscal Year: 2001
    ....
  56. PATHOGENESIS OF HIV INDUCED IMMUNODEFICIENCY
    Ashley Haase; Fiscal Year: 2008
    ..abstract_text> ..
  57. Substrate/Inhibitor Specificity of FIV and HIV PRs
    John Elder; Fiscal Year: 2006
    ..These studies will advance our understanding of the structural basis for drug resistance and lead to development of effective inhibitors less susceptible to escape via mutations within PR. ..
  58. SODIUM CHANNEL REGULATION AND DISEASE
    Andrew Escayg; Fiscal Year: 2008
    ..This study will provide new, clinically relevant insights into the regulation of SCN1A and the mechanisms that determine neuronal excitability. ..
  59. FREE RADICALS IN MENTAL HEALTH & NEUROBIOLOGY
    Stephen Bondy; Fiscal Year: 2005
    ..The long-term support of this series of annual meetings will permit better planning for meeting organizers, attendees, students, and publishers. ..
  60. Role of Candidate Alleles in Cognitive Outcome After TBI
    Thomas McAllister; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  61. Role of ornithine decarboxylase in Ras transformation
    Lisa Shantz; Fiscal Year: 2006
    ..Keratinocytes from D1/AZ mice will also be used to analyze direct interactions of AZ with cyclin D1, to test whether other properties of AZ are important for deregulation of cell proliferation in tumor development. ..
  62. Role of PPARs in Atherosclerosis
    Ajay Chawla; Fiscal Year: 2006
    ..abstract_text> ..