atopic dermatitis

Summary

Summary: A chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. It is manifested by lichenification, excoriation, and crusting, mainly on the flexural surfaces of the elbow and knee. In infants it is known as infantile eczema.

Top Publications

  1. ncbi Diagnosis and treatment of atopic dermatitis in children and adults: European Academy of Allergology and Clinical Immunology/American Academy of Allergy, Asthma and Immunology/PRACTALL Consensus Report
    Cezmi A Akdis
    Swiss Institute of Allergy and Asthma Research, Davos
    J Allergy Clin Immunol 118:152-69. 2006
  2. ncbi How epidemiology has challenged 3 prevailing concepts about atopic dermatitis
    Hywel Williams
    Centre of Evidence Based Dermatology, University of Nottingham King s Meadow Campus, Lenton Lane, Nottingham NG7 2NR, UK
    J Allergy Clin Immunol 118:209-13. 2006
  3. ncbi Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis
    Colin N A Palmer
    Population Pharmacogenetics Group, Biomedical Research Centre, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
    Nat Genet 38:441-6. 2006
  4. doi Atopic dermatitis
    Thomas Bieber
    Department of Dermatology and Allergy, University of Bonn, Bonn, Germany
    N Engl J Med 358:1483-94. 2008
  5. ncbi Human epithelial cells trigger dendritic cell mediated allergic inflammation by producing TSLP
    Vassili Soumelis
    DNAX, 901 California Avenue, Palo Alto, CA 94304, USA
    Nat Immunol 3:673-80. 2002
  6. ncbi Endogenous antimicrobial peptides and skin infections in atopic dermatitis
    Peck Y Ong
    Division of Allergy and Immunology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    N Engl J Med 347:1151-60. 2002
  7. pmc New insights into atopic dermatitis
    Donald Y M Leung
    Division of Pediatric Allergy Immunology, National Jewish Medical and Research Center, Department of Pediatrics, University of Colorado Health Sciences Center, Denver, Colorado 80206, USA
    J Clin Invest 113:651-7. 2004
  8. ncbi A prospective study on the clinical features of chronic canine atopic dermatitis and its diagnosis
    Claude Favrot
    Clinical for Small Animal Internal Medicine, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland
    Vet Dermatol 21:23-31. 2010
  9. ncbi Unique mutations in the filaggrin gene in Japanese patients with ichthyosis vulgaris and atopic dermatitis
    Toshifumi Nomura
    Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    J Allergy Clin Immunol 119:434-40. 2007
  10. ncbi Filaggrin mutations, atopic eczema, hay fever, and asthma in children
    Stephan Weidinger
    Department of Dermatology and Allergy, Technical University Munich, Munich, Germany
    J Allergy Clin Immunol 121:1203-1209.e1. 2008

Detail Information

Publications360 found, 100 shown here

  1. ncbi Diagnosis and treatment of atopic dermatitis in children and adults: European Academy of Allergology and Clinical Immunology/American Academy of Allergy, Asthma and Immunology/PRACTALL Consensus Report
    Cezmi A Akdis
    Swiss Institute of Allergy and Asthma Research, Davos
    J Allergy Clin Immunol 118:152-69. 2006
    There are remarkable differences in the diagnostic and therapeutic management of atopic dermatitis practiced by dermatologists and pediatricians in different countries...
  2. ncbi How epidemiology has challenged 3 prevailing concepts about atopic dermatitis
    Hywel Williams
    Centre of Evidence Based Dermatology, University of Nottingham King s Meadow Campus, Lenton Lane, Nottingham NG7 2NR, UK
    J Allergy Clin Immunol 118:209-13. 2006
    We challenge 3 prevailing concepts in understanding atopic dermatitis using data from epidemiologic studies...
  3. ncbi Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis
    Colin N A Palmer
    Population Pharmacogenetics Group, Biomedical Research Centre, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
    Nat Genet 38:441-6. 2006
    Atopic disease, including atopic dermatitis (eczema), allergy and asthma, has increased in frequency in recent decades and now affects approximately 20% of the population in the developed world...
  4. doi Atopic dermatitis
    Thomas Bieber
    Department of Dermatology and Allergy, University of Bonn, Bonn, Germany
    N Engl J Med 358:1483-94. 2008
  5. ncbi Human epithelial cells trigger dendritic cell mediated allergic inflammation by producing TSLP
    Vassili Soumelis
    DNAX, 901 California Avenue, Palo Alto, CA 94304, USA
    Nat Immunol 3:673-80. 2002
    ..TSLP was highly expressed by epithelial cells, especially keratinocytes from patients with atopic dermatitis. TSLP expression was associated with Langerhans cell migration and activation in situ...
  6. ncbi Endogenous antimicrobial peptides and skin infections in atopic dermatitis
    Peck Y Ong
    Division of Allergy and Immunology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    N Engl J Med 347:1151-60. 2002
    ..We compared the levels of expression of LL-37 and human beta-defensin 2 (HBD-2) in inflamed skin from patients with atopic dermatitis and from those with psoriasis.
  7. pmc New insights into atopic dermatitis
    Donald Y M Leung
    Division of Pediatric Allergy Immunology, National Jewish Medical and Research Center, Department of Pediatrics, University of Colorado Health Sciences Center, Denver, Colorado 80206, USA
    J Clin Invest 113:651-7. 2004
    b>Atopic dermatitis is a chronic inflammatory skin disease associated with cutaneous hyperreactivity to environmental triggers and is often the first step in the atopic march that results in asthma and allergic rhinitis...
  8. ncbi A prospective study on the clinical features of chronic canine atopic dermatitis and its diagnosis
    Claude Favrot
    Clinical for Small Animal Internal Medicine, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland
    Vet Dermatol 21:23-31. 2010
    Canine atopic dermatitis (CAD) is a multifaceted disease associated with exposure to various offending agents such as environmental and food allergens...
  9. ncbi Unique mutations in the filaggrin gene in Japanese patients with ichthyosis vulgaris and atopic dermatitis
    Toshifumi Nomura
    Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    J Allergy Clin Immunol 119:434-40. 2007
    ..Recently, mutations in the filaggrin gene, FLG, were identified in European families with ichthyosis vulgaris (IV) and shown to be an important predisposing factor for atopic dermatitis (AD).
  10. ncbi Filaggrin mutations, atopic eczema, hay fever, and asthma in children
    Stephan Weidinger
    Department of Dermatology and Allergy, Technical University Munich, Munich, Germany
    J Allergy Clin Immunol 121:1203-1209.e1. 2008
    ..However, their role in the development of other atopic diseases such as asthma and rhinitis has not yet been clarified in large population-based studies...
  11. ncbi Atopic dermatitis
    Donald Y M Leung
    Division of Pediatric Allergy and Immunology, National Jewish Medical and Research Center, Denver, CO 80206, USA
    Lancet 361:151-60. 2003
    b>Atopic dermatitis is a highly pruritic chronic inflammatory skin disorder affecting 10-20% of children worldwide. Symptoms can persist or begin in adulthood. It is also the most common cause of occupational skin disease in adults...
  12. ncbi Epidermal barrier dysfunction in atopic dermatitis
    Michael J Cork
    The Paediatric Dermatology Clinic, Sheffield Children s Hospital, Sheffield, UK
    J Invest Dermatol 129:1892-908. 2009
    b>Atopic dermatitis (AD) is a multifactorial, heterogenous disease that arises as a result of the interaction between both environmental and genetic factors...
  13. ncbi Clinical practice. Atopic dermatitis
    Hywel C Williams
    Center of Evidence Based Dermatology, Queen s Medical Center, University of Nottingham, Nottingham, United Kingdom
    N Engl J Med 352:2314-24. 2005
  14. pmc A pilot study of emollient therapy for the primary prevention of atopic dermatitis
    Eric L Simpson
    Department of Dermatology, Oregon Health and Science University, Portland, Oregon 97239 4501, USA
    J Am Acad Dermatol 63:587-93. 2010
    Prevention strategies in atopic dermatitis (AD) using allergen avoidance have not been consistently effective. New research reveals the importance of the skin barrier in the development of AD and possibly food allergy and asthma...
  15. ncbi A common variant on chromosome 11q13 is associated with atopic dermatitis
    Jorge Esparza-Gordillo
    Pediatric Pneumology and Immunology, Charite Universitatsmedizin Berlin, Germany
    Nat Genet 41:596-601. 2009
    We conducted a genome-wide association study in 939 individuals with atopic dermatitis and 975 controls as well as 270 complete nuclear families with two affected siblings...
  16. pmc Characterization of a hapten-induced, murine model with multiple features of atopic dermatitis: structural, immunologic, and biochemical changes following single versus multiple oxazolone challenges
    Mao Qiang Man
    Dermatology Service, Veterans Affairs Medical Center, and Department of Dermatology, University of California, San Francisco, California 94121, USA
    J Invest Dermatol 128:79-86. 2008
    b>Atopic dermatitis (AD) is a chronic dermatosis bearing clinical, histological, and immunologic similarities to chronic allergic contact dermatitis (ACD)...
  17. ncbi Atopic dermatitis and the atopic march
    Jonathan M Spergel
    Division of Allergy and Immunology, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    J Allergy Clin Immunol 112:S118-27. 2003
    b>Atopic dermatitis (AD), one of the most common skin disorders seen in infants and children, usually has its onset during the first 6 months of life...
  18. pmc Animal models of atopic dermatitis
    Haoli Jin
    Division of Immunology, Department of Medicine, Children s Hospital, Department of Pediatrics, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Invest Dermatol 129:31-40. 2009
    b>Atopic dermatitis (AD) is characterized by allergic skin inflammation. A hallmark of AD is dry itchy skin due, at least in part, to defects in skin genes that are important for maintaining barrier function...
  19. ncbi Comprehensive analysis of the gene encoding filaggrin uncovers prevalent and rare mutations in ichthyosis vulgaris and atopic eczema
    Aileen Sandilands
    Epithelial Genetics Group, Human Genetics Unit, Division of Pathology and Neuroscience, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
    Nat Genet 39:650-4. 2007
    ..i. = 20-1,136)). We found three additional rare null mutations in this case series, suggesting that the genetic architecture of filaggrin-related atopic dermatitis consists of both prevalent and rare risk alleles.
  20. ncbi The burden of disease associated with filaggrin mutations: a population-based, longitudinal birth cohort study
    John Henderson
    Department of Community Based Medicine, University of Bristol, Bristol, United Kingdom
    J Allergy Clin Immunol 121:872-7.e9. 2008
    ..Atopic disease is a major health problem. Mutations in the filaggrin gene (FLG) confer major susceptibility to eczema and related asthma...
  21. ncbi Possible pathogenic role of Th17 cells for atopic dermatitis
    Chizuko Koga
    Department of Dermatology, University of Environmental and Occupational Health, Kitakyushu, Japan
    J Invest Dermatol 128:2625-30. 2008
    ..of psoriasis and keratinocyte production of certain cytokines, the involvement of T helper cell 17 (Th17) in atopic dermatitis (AD) is an issue to be elucidated...
  22. ncbi Loss-of-function variations within the filaggrin gene predispose for atopic dermatitis with allergic sensitizations
    Stephan Weidinger
    Department of Dermatology and Allergy Biederstein, Technical University Munich, Biedersteiner Strasse 29, 80802 Munich, Germany
    J Allergy Clin Immunol 118:214-9. 2006
    b>Atopic dermatitis (AD) is a chronic inflammatory skin disease with a strong genetic background...
  23. ncbi Filaggrin in atopic dermatitis
    Aileen Sandilands
    Department of Paediatric Dermatology, Our Lady s Children s Hospital, Dublin, Ireland
    J Allergy Clin Immunol 124:R2-6. 2009
    ..In this review we highlight recent advances in our understanding of the FLG genetics in the cause of eczema and related complex diseases...
  24. pmc Recent insights into atopic dermatitis and implications for management of infectious complications
    Mark Boguniewicz
    Division of Pediatric Allergy Immunology, Department of Pediatrics, National Jewish Health and University of Colorado School of Medicine, 1400 Jackson St, Rm J310, Denver, CO 80206, USA
    J Allergy Clin Immunol 125:4-13; quiz 14-5. 2010
    b>Atopic dermatitis (AD) is a common complex disease that frequently follows a chronic relapsing course and affects the quality of life of patients and families in a significant manner...
  25. pmc Mast cells in atopic dermatitis
    Toshiaki Kawakami
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    Curr Opin Immunol 21:666-78. 2009
    ..mast cells, as well as sensitization to allergens, IgE elevation, and increased mast cells in a majority of atopic dermatitis patients, mast cells are believed to be involved in the pathogenesis of atopic dermatitis...
  26. pmc Cytokine modulation of atopic dermatitis filaggrin skin expression
    Michael D Howell
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Allergy Clin Immunol 120:150-5. 2007
    b>Atopic dermatitis (AD) is a chronic inflammatory skin disease that is characterized by a defective skin barrier function. Recent studies have reported mutations of the skin barrier gene encoding filaggrin in a subset of patients with AD.
  27. ncbi Cytokines and chemokines orchestrate atopic skin inflammation
    Bernhard Homey
    Department of Dermatology, Heinrich Heine University, Moorenstrasse 5, Dusseldorf 40225, Germany
    J Allergy Clin Immunol 118:178-89. 2006
    b>Atopic dermatitis (AD) is a common pruritic and chronically relapsing inflammatory skin disease...
  28. ncbi New perspectives on epidermal barrier dysfunction in atopic dermatitis: gene-environment interactions
    Michael J Cork
    Pediatric Dermatology Clinic, Children s Hospital, Sheffield S10 2RX, UK
    J Allergy Clin Immunol 118:3-21; quiz 22-3. 2006
    b>Atopic dermatitis (AD) is a multifactorial, chronic inflammatory skin disorder in which genetic mutations and cutaneous hyperreactivity to environmental stimuli play a causative role...
  29. ncbi Ceramide-dominant barrier repair lipids alleviate childhood atopic dermatitis: changes in barrier function provide a sensitive indicator of disease activity
    Sarah L Chamlin
    Department of Dermatology, University of California, San Francisco, USA
    J Am Acad Dermatol 47:198-208. 2002
    It is currently fashionable to consider atopic dermatitis (AD), like other inflammatory dermatoses, as immunologic in pathogenesis ("inside-outside" hypothesis)...
  30. ncbi The natural course of atopic dermatitis from birth to age 7 years and the association with asthma
    Sabina Illi
    Department of Pediatric Pneumology and Immunology, Charite, Dr von Haunersches Kinderspital, Lindwurmastrasse 4, 80337 Munich, Germany
    J Allergy Clin Immunol 113:925-31. 2004
    b>Atopic dermatitis (AD) is considered to be one of the first manifestations in the atopic march. However, few prospective studies on AD and its association with childhood asthma exist.
  31. ncbi Clinical trial evaluating the efficacy and safety of cyclosporine in dogs with atopic dermatitis
    Jean Steffan
    Novartis Animal Health, CH4002 Basel, Switzerland
    J Am Vet Med Assoc 226:1855-63. 2005
    To determine efficacy and safety of cyclosporine in the treatment of atopic dermatitis among dogs in North America.
  32. pmc Atopic dermatitis-like disease and associated lethal myeloproliferative disorder arise from loss of Notch signaling in the murine skin
    Alexis Dumortier
    Ecole Polytechnique Fédérale de Lausanne EPFL SV ISREC, Lausanne, Switzerland
    PLoS ONE 5:e9258. 2010
    ..Moreover, skin specific loss of Notch signaling in the embryo results in skin barrier defects accompanied by a B-lymphoproliferative disease. However, much less is known about the consequences of loss of Notch signaling after birth...
  33. pmc "Outside-to-inside" (and now back to "outside") pathogenic mechanisms in atopic dermatitis
    Peter M Elias
    Dermatology Service, Veterans Affairs Medical Center, and Department of Dermatology, University of California, San Francisco, California 94121, USA
    J Invest Dermatol 128:1067-70. 2008
    The pathogenesis of atopic dermatitis (AD) has been attributed largely to abnormalities in the adaptive immune system, with key roles played by T-helper 1(Th1)/Th2 cell dysregulation, IgE production, dendritic cell signaling, and mast-..
  34. ncbi Identification of Malassezia species isolated from patients with seborrhoeic dermatitis, atopic dermatitis, pityriasis versicolor and normal subjects
    A Nakabayashi
    Department of Dermatology, Showa University Fujigaoka Hospital, Yokohama, Japan
    Med Mycol 38:337-41. 2000
    We identified Malassezia species isolated from 42 patients with seborrhoeic dermatitis, 17 patients with atopic dermatitis, 22 patients with pityriasis versicolor, 35 normal subjects and 73 healthy medical students...
  35. pmc Basis for the barrier abnormality in atopic dermatitis: outside-inside-outside pathogenic mechanisms
    Peter M Elias
    Dermatology Service, Veterans Affairs Medical Center, San Francisco, Calif 94121, USA
    J Allergy Clin Immunol 121:1337-43. 2008
    Until quite recently, the pathogenesis of atopic dermatitis (AD) has been attributed to primary abnormalities of the immune system...
  36. ncbi The ACVD task force on canine atopic dermatitis (I): incidence and prevalence
    A Hillier
    Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, 601 Vernon L Tharp St, Columbus, OH 43017, USA
    Vet Immunol Immunopathol 81:147-51. 2001
    There is an increasing incidence of atopic diseases (asthma, allergic rhinitis and atopic dermatitis) in humans, especially in developed countries...
  37. ncbi Timing of solid food introduction in relation to atopic dermatitis and atopic sensitization: results from a prospective birth cohort study
    Anne Zutavern
    Institute of Epidemiology, GSF National Research Center for Environment and Health, Neuherberg, Germany
    Pediatrics 117:401-11. 2006
    ..This study investigates whether a delayed introduction of solids (past 4 months or 6 months) is protective against the development of atopic dermatitis (AD) and atopic sensitization when considering reverse causality.
  38. pmc Glycoproteomic analysis of plasma from patients with atopic dermatitis: CD5L and ApoE as potential biomarkers
    Won Kon Kim
    Translational Research Center, KRIBB, Daejeon 305 806, Korea
    Exp Mol Med 40:677-85. 2008
    b>Atopic dermatitis (AD) is an inflammatory skin disorder that is both uncomfortable and distressing to patients, and its prevalence has been steadily increasing...
  39. ncbi Oral treatment with probiotic Lactobacillus johnsonii NCC533 (La1) for a specific part of the weaning period prevents the development of atopic dermatitis induced after maturation in model mice, NC/Nga
    R Inoue
    Laboratory of Animal Science, Kyoto Prefectural University, Shimogamo, Kyoto, Japan
    Br J Dermatol 156:499-509. 2007
    The inhibitory effect of probiotic bacteria on atopic dermatitis has been shown in human infants, but the mechanism is still unclear.
  40. ncbi Atopic dermatitis: a disease caused by innate immune defects?
    Anna De Benedetto
    Department of Dermatology, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Invest Dermatol 129:14-30. 2009
    b>Atopic dermatitis (AD) is a common chronic inflammatory skin disease that has increased in prevalence over the last half century...
  41. ncbi Interventions for atopic dermatitis in dogs: a systematic review of randomized controlled trials
    Thierry Olivry
    Department of Clinical Sciences and Center for Comparative Medicine and Translational Research, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA
    Vet Dermatol 21:4-22. 2010
    ..the guidelines of the Cochrane collaboration, was to assess the effects of interventions for treatment of atopic dermatitis (AD) in dogs...
  42. ncbi Cytokine milieu of atopic dermatitis, as compared to psoriasis, skin prevents induction of innate immune response genes
    Ichiro Nomura
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Immunol 171:3262-9. 2003
    b>Atopic dermatitis (AD) and psoriasis are the two most common chronic skin diseases. However patients with AD, but not psoriasis, suffer from frequent skin infections...
  43. ncbi ETFAD/EADV eczema task force 2009 position paper on diagnosis and treatment of atopic dermatitis
    U Darsow
    Department of Dermatology and Allergy Biederstein, Technische Universitat Munchen
    J Eur Acad Dermatol Venereol 24:317-28. 2010
    The diagnosis of atopic dermatitis (AD) is made using evaluated clinical criteria. Management of AD must consider the symptomatic variability of the disease.
  44. ncbi A systematic review and meta-analysis of the efficacy and safety of cyclosporin for the treatment of atopic dermatitis in dogs
    Jean Steffan
    Novartis Animal Health, Basel, Switzerland
    Vet Dermatol 17:3-16. 2006
    The efficacy of cyclosporin A (CsA) for the treatment of canine atopic dermatitis was evaluated based on the systematic review of prospective clinical trials published between 2001 and 2005...
  45. pmc IL-18 contributes to the spontaneous development of atopic dermatitis-like inflammatory skin lesion independently of IgE/stat6 under specific pathogen-free conditions
    Hiroshi Konishi
    Department of Dermatology, Mie University School of Medicine, Tsu 514 8507, Japan
    Proc Natl Acad Sci U S A 99:11340-5. 2002
    b>Atopic dermatitis (AD) is a pruritic inflammatory skin disease...
  46. ncbi Stress-induced immunomodulation is altered in patients with atopic dermatitis
    A Buske-Kirschbaum
    Department of Psychobiology, University of Trier, Universitätsring 1, 54286, Trier, Germany
    J Neuroimmunol 129:161-7. 2002
    b>Atopic dermatitis (AD) is a chronically relapsing inflammatory skin disease with main symptoms such as eczematous skin lesions and severe pruritus...
  47. ncbi Filaggrin mutations that confer risk of atopic dermatitis confer greater risk for eczema herpeticum
    Pei Song Gao
    Johns Hopkins Asthma and Allergy Center, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    J Allergy Clin Immunol 124:507-13, 513.e1-7. 2009
    ..2282del4 in the skin barrier gene, filaggrin (FLG), represent the most replicated genetic risk factors for atopic dermatitis (AD). Associations have not been reported in African ancestry populations...
  48. ncbi Reduced IFN-gamma- and enhanced IL-4-producing CD4+ cord blood T cells are associated with a higher risk for atopic dermatitis during the first 2 yr of life
    Gunda Herberth
    UFZ Helmholtz Centre for Environmental Research Leipzig, Department of Environmental Immunology, Leipzig, Germany
    Pediatr Allergy Immunol 21:5-13. 2010
    ..During the first 2 yr of life, 17.3% of the children developed a physician-diagnosed atopic dermatitis. Children with reduced frequencies of interferon-gamma (IFN-gamma)-producing CD4(+) T cells in the CB (1st ..
  49. pmc The role of microorganisms in atopic dermatitis
    Barbara S Baker
    Clin Exp Immunol 144:1-9. 2006
    b>Atopic dermatitis (AD) is a common, fluctuating skin disease that is often associated with atopic conditions such as asthma and IgE-mediated food allergy and whose skin lesions are characterized by a Th-2 cell-mediated response to ..
  50. ncbi IgE-mediated and T cell-mediated autoimmunity against manganese superoxide dismutase in atopic dermatitis
    Peter Schmid-Grendelmeier
    Swiss Institute of Allergy and Asthma Research, Davos, Switherland
    J Allergy Clin Immunol 115:1068-75. 2005
    Autoreactivity of patients with atopic dermatitis (AD) to human proteins has been postulated as a decisive pathogenetic factor for AD.
  51. ncbi From atopic dermatitis to asthma: the atopic march
    Jonathan M Spergel
    Division of Allergy and Immunology, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 4399, USA
    Ann Allergy Asthma Immunol 105:99-106; quiz 107-9, 117. 2010
    ..To examine the mechanisms whereby allergen exposure through the epidermis could initiate systemic allergy and predispose individuals to the development of 1 or more atopic diseases via the so-called atopic march...
  52. ncbi Usefulness of specific immunotherapy in patients with atopic dermatitis and allergic sensitization to house dust mites: a multi-centre, randomized, dose-response study
    T Werfel
    Department of Dermatology and Allergology, Hannover Medical School, Hannover, Germany
    Allergy 61:202-5. 2006
    The effect of specific immunotherapy (SIT) on eczema in atopic dermatitis is not known...
  53. ncbi Unravelling the skin barrier: a new paradigm for atopic dermatitis and house dust mites
    Rosanna Marsella
    Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL, USA
    Vet Dermatol 20:533-40. 2009
    b>Atopic dermatitis (AD) is a chronic relapsing inflammatory skin disease caused by complex interactions between genetics and environmental factors...
  54. ncbi The ACVD task force on canine atopic dermatitis (XV): fundamental concepts in clinical diagnosis
    D J DeBoer
    Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin, 2015 Linden Drive West, Madison, WI 53706, USA
    Vet Immunol Immunopathol 81:271-6. 2001
    The clinical signs of atopic dermatitis (AD) in man and in dogs are variable, and there is no single physical or historical feature that, if present, indicates the presence of AD...
  55. ncbi Probiotic supplementation for the first 6 months of life fails to reduce the risk of atopic dermatitis and increases the risk of allergen sensitization in high-risk children: a randomized controlled trial
    Angie L Taylor
    School of Paediatrics and Child Health, University of Western Australia, Perth, Australia
    J Allergy Clin Immunol 119:184-91. 2007
    ..Despite preliminary evidence, the role of probiotics in allergy prevention is unclear...
  56. pmc Low expression of the IL-23/Th17 pathway in atopic dermatitis compared to psoriasis
    Emma Guttman-Yassky
    Laboratory for Investigative Dermatology, The Rockefeller University, New York, NY 10021, USA
    J Immunol 181:7420-7. 2008
    The classical Th1/Th2 paradigm previously defining atopic dermatitis (AD) and psoriasis has recently been challenged with the discovery of Th17 T cells that synthesize IL-17 and IL-22...
  57. pmc Effects of probiotics on atopic dermatitis: a randomised controlled trial
    S Weston
    School of Paediatrics and Child Health Research, University of Western Australia, Perth, Australia
    Arch Dis Child 90:892-7. 2005
    The aim of the study was to investigate the effects of probiotics on moderate or severe atopic dermatitis (AD) in young children.
  58. pmc Abnormal skin barrier in the etiopathogenesis of atopic dermatitis
    Peter M Elias
    Veterans Affairs Medical Center, Department of Dermatology, University of California, San Francisco, 94121, USA
    Curr Opin Allergy Clin Immunol 9:437-46. 2009
    ..dysregulation, IgE production, mast cell hyperactivity, and dendritic cell signaling in the pathogenesis of atopic dermatitis. Accordingly, current therapy has been largely directed towards ameliorating Th2-mediated inflammation and/..
  59. ncbi Treatment of canine atopic dermatitis: 2010 clinical practice guidelines from the International Task Force on Canine Atopic Dermatitis
    Thierry Olivry
    Department of Clinical Sciences and Center for Comparative Medicine and Translational Research, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA
    Vet Dermatol 21:233-48. 2010
    b>Atopic dermatitis (AD) is a common chronic relapsing pruritic skin disease of dogs for which treatment has varied over time and geographical location...
  60. ncbi Enhanced expression and secretion of antimicrobial peptides in atopic dermatitis and after superficial skin injury
    Jurgen Harder
    Department of Dermatology, Allergology, and Venerology, University Hospital Schleswig Holstein, Campus Kiel, Kiel, Germany
    J Invest Dermatol 130:1355-64. 2010
    ..The expression of AMPs in atopic dermatitis (AD) is still emerging...
  61. ncbi Intrinsically defective skin barrier function in children with atopic dermatitis correlates with disease severity
    Jayanta Gupta
    Division of Epidemiology and Biostatistics, Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    J Allergy Clin Immunol 121:725-730.e2. 2008
    ..evidence supports that an underlying defect in skin barrier function contributes to the pathogenesis of atopic dermatitis (AD)...
  62. ncbi Development of atopic dermatitis during the first 3 years of life: the Copenhagen prospective study on asthma in childhood cohort study in high-risk children
    Liselotte Brydensholt Halkjaer
    Danish Pediatric Asthma Centre, Department of Pediatrics, Copenhagen University Hospital, Gentofte, Denmark
    Arch Dermatol 142:561-6. 2006
    To describe the development of atopic dermatitis (AD) during the first 3 years of life and identify the localization of the early skin lesions that predicts the development of AD.
  63. ncbi Null mutations in the filaggrin gene (FLG) determine major susceptibility to early-onset atopic dermatitis that persists into adulthood
    Jonathan N W N Barker
    St John s Institute of Dermatology, King s College London, St Thomas s Hospital, London, UK
    J Invest Dermatol 127:564-7. 2007
    b>Atopic dermatitis (AD) is a common disease with a complex etiology in childhood and adult life. A significant proportion of childhood AD is transient, but in many cases it persists into adulthood...
  64. ncbi Long-term follow-up of atopic dermatitis: retrospective analysis of related risk factors and association with concomitant allergic diseases
    Giampaolo Ricci
    Department of Pediatrics, University of Bologna, Italy
    J Am Acad Dermatol 55:765-71. 2006
    The association of atopic dermatitis (AD) with other allergic diseases has been extensively studied; however, there is a lack of reports focusing on long-term studies of the clinical and allergometric evaluations observed during the ..
  65. ncbi Genome-wide association analysis of canine atopic dermatitis and identification of disease related SNPs
    Shona Hiedi Wood
    Department of Veterinary Pathology, Faculty of Veterinary Science, The University of Liverpool, Liverpool, L69 3ZJ, UK
    Immunogenetics 61:765-72. 2009
    ..Here, we describe the first study to perform a genome-wide association study in canine atopic dermatitis (cAD) using the Illumina Canine SNP20 array, containing 22,362 single-nucleotide polymorphisms (SNPs)...
  66. ncbi Effect of probiotic Lactobacillus strains in children with atopic dermatitis
    Vibeke Rosenfeldt
    Research Department of Human Nutrition and the LMC Center for Advanced Food Studies, The Royal Veterinary and Agricultural University, Copenhagen, Denmark
    J Allergy Clin Immunol 111:389-95. 2003
    Recent studies suggest that oral bacteriotherapy with probiotics might be useful in the management of atopic dermatitis (AD).
  67. ncbi Guidelines of care for atopic dermatitis, developed in accordance with the American Academy of Dermatology (AAD)/American Academy of Dermatology Association "Administrative Regulations for Evidence-Based Clinical Practice Guidelines"
    Jon M Hanifin
    American Academy of Dermatology, PO Box 4014, Schaumburg, IL 60168 4014, USA
    J Am Acad Dermatol 50:391-404. 2004
  68. ncbi Cutting edge: the orphan chemokine receptor G protein-coupled receptor-2 (GPR-2, CCR10) binds the skin-associated chemokine CCL27 (CTACK/ALP/ILC)
    B Homey
    DNAX Research Institute, Palo Alto, CA 94304, USA
    J Immunol 164:3465-70. 2000
    ..Taken together, these observations suggest a role for this novel ligand/receptor pair in both skin homeostasis as well as a potential role in inflammatory responses...
  69. ncbi The use of recombinant omega interferon therapy in canine atopic dermatitis: a double-blind controlled study
    Didier Noel Carlotti
    Aquivet Clinique Vétérinaire, avenue de la forêt, Parc d activités Mermoz, F 33320 Eysines Bordeaux, France
    Vet Dermatol 20:405-11. 2009
    ..reduced doses of omega interferon (rFeIFN-omega) (Virbagen Omega) could improve the clinical signs of canine atopic dermatitis (CAD) over a 6-month period, in comparison with cyclosporin...
  70. ncbi TCDD exposure exacerbates atopic dermatitis-related inflammation in NC/Nga mice
    Tomohiro Ito
    Environmental Health Sciences Division, National Institute for Environmental Studies, Tsukuba, Ibaraki, Japan
    Toxicol Lett 177:31-7. 2008
    ..study showed that 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure of NC/Nga mice, a mouse model of atopic dermatitis, induces no dermal changes...
  71. ncbi Serum, cheek cell and breast milk fatty acid compositions in infants with atopic and non-atopic eczema
    K Laitinen
    Department of Paediatrics, Turku University Central Hospital, Turku, Finland
    Clin Exp Allergy 36:166-73. 2006
    ..The major theory implicating diet with allergic diseases is associated with altered food consumption and subsequent changes in fatty acid composition...
  72. ncbi Genetic susceptibility to atopic dermatitis
    Chikako Kiyohara
    Department of Preventive Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Allergol Int 57:39-56. 2008
    b>Atopic dermatitis (AD) is a chronic inflammatory skin disorder with an increasing prevalence in industrialized countries. AD belongs to the group of allergic disorders that includes food allergy, allergic rhinitis, and asthma...
  73. ncbi IL-10 augments the IFN-gamma and TNF-alpha induced TARC production in HaCaT cells: a possible mechanism in the inflammatory reaction of atopic dermatitis
    C Vestergaard
    Department of Dermatology, Marselisborg Hospital, University of Aarhus, Research Laboratory B, Oerumsgade 11, 8000 Aarhus C, Aarhus, Denmark
    J Dermatol Sci 26:46-54. 2001
    ..b>Atopic dermatitis is generally believed to be a Th(2)-type disease, and TARC has been shown to be expressed in the skin ..
  74. ncbi The impact of stress on the development and expression of atopy
    Rosalind J Wright
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Curr Opin Allergy Clin Immunol 5:23-9. 2005
    ..feature of atopy predisposing to a number of clinically expressed disorders including allergic rhinitis, atopic dermatitis or eczema, and allergic asthma...
  75. ncbi The toll-like receptor 2 R753Q polymorphism defines a subgroup of patients with atopic dermatitis having severe phenotype
    Parviz Ahmad-Nejad
    J Allergy Clin Immunol 113:565-7. 2004
  76. ncbi IL-32 is expressed by human primary keratinocytes and modulates keratinocyte apoptosis in atopic dermatitis
    Norbert Meyer
    Swiss Institute of Allergy and Asthma Research SIAF, University of Zurich, Davos, Switzerland High altitude Clinic of Davos, Davos Wolfgang, Switzerland
    J Allergy Clin Immunol 125:858-865.e10. 2010
    Keratinocyte (KC) apoptosis is an important mechanism of eczema and spongiosis in patients with atopic dermatitis (AD) and is mediated by IFN-gamma, which is secreted by T(H)1 cells...
  77. ncbi Validation of CADESI-03, a severity scale for clinical trials enrolling dogs with atopic dermatitis
    Thierry Olivry
    Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, USA
    Vet Dermatol 18:78-86. 2007
    In dogs, atopic dermatitis (AD) is a common and chronic allergic skin disease that often necessitates treatment with pharmacological interventions...
  78. ncbi Cyclosporin A pharmacokinetics and efficacy in the treatment of atopic dermatitis in dogs
    J Steffan
    Novartis Animal Health, WRO 1032 2 50, CH 4002 Basle, Switzerland
    J Vet Pharmacol Ther 27:231-8. 2004
    ..In a third study, in a clinical trial evaluating CsA for the treatment of canine atopic dermatitis, a single blood sample was collected in dogs which had received CsA for 28 days...
  79. pmc Changes of antimicrobial peptides and transepidermal water loss after topical application of tacrolimus and ceramide-dominant emollient in patients with atopic dermatitis
    Kui Young Park
    Department of Dermatology, Chung Ang University College of Medicine, Seoul, Korea
    J Korean Med Sci 25:766-71. 2010
    ..water loss (TEWL) and downregulated antimicrobial peptides (AMPs) are observed in patients with atopic dermatitis (AD)...
  80. ncbi Antioxidant activity, lipid peroxidation and skin diseases. What's new
    S Briganti
    Cutaneous Physiopathology Laboratory, San Gallicano Dermatological Institute, 25 A Via S Gallicano, 00153 Rome, Italy
    J Eur Acad Dermatol Venereol 17:663-9. 2003
    ..Based on these findings, the review summarises the possible correlations between antioxidant imbalance, lipid oxidative breakage and skin diseases, from both a pathological and therapeutic points of view...
  81. ncbi Determination of CADESI-03 thresholds for increasing severity levels of canine atopic dermatitis
    Thierry Olivry
    Department of Clinical Sciences and Center for Comparative Medicine and Translational Research, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, USA
    Vet Dermatol 19:115-9. 2008
    To evaluate the extent and severity of skin lesions in clinical trials enrolling dogs with atopic dermatitis (AD), the International Task Force on Canine Atopic Dermatitis recently recommended the use of the third version of the CADESI...
  82. ncbi Cellular and molecular mechanisms in atopic dermatitis
    Michiko K Oyoshi
    Division of Immunology, Children s Hospital and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA
    Adv Immunol 102:135-226. 2009
    b>Atopic dermatitis (AD) is a pruritic inflammatory skin disease associated with a personal or family history of allergy. The prevalence of AD is on the rise and estimated at approximately 17% in the USA...
  83. ncbi Comparison of cyclosporine A with methylprednisolone for treatment of canine atopic dermatitis: a parallel, blinded, randomized controlled trial
    Jean Steffan
    Novartis Animal Health Inc, CH 4002, Basel, Switzerland
    Vet Dermatol 14:11-22. 2003
    ..CsA group, 117 dogs) in comparison with methylprednisolone (MP group, 59 dogs) in the treatment of atopic dermatitis for 4 months. Mean induction dose of both drugs (5 mg/kg CsA, 0...
  84. pmc A milieu of regulatory elements in the epidermal differentiation complex syntenic block: implications for atopic dermatitis and psoriasis
    Cristina de Guzman Strong
    Genetics and Molecular Biology Branch, National Human Genome Research Institute, NIH, Bethesda, MD, USA
    Hum Mol Genet 19:1453-60. 2010
    Two common inflammatory skin disorders with impaired barrier, atopic dermatitis (AD) and psoriasis, share distinct genetic linkage to the Epidermal Differentiation Complex (EDC) locus on 1q21...
  85. ncbi Guidelines for management of atopic dermatitis
    Hidehisa Saeki
    Department of Dermatology, Graduate School of Medicine, University of Tokyo, Tokyo
    J Dermatol 36:563-77. 2009
    b>Atopic dermatitis (AD) is a chronic relapsing eczematous skin disease characterized by pruritus and inflammation and accompanied by cutaneous physiological dysfunction (dry and barrier-disrupted skin)...
  86. pmc IL-22-producing "T22" T cells account for upregulated IL-22 in atopic dermatitis despite reduced IL-17-producing TH17 T cells
    Kristine E Nograles
    Laboratory for Investigative Dermatology, The Rockefeller University, New York, NY 10065, USA
    J Allergy Clin Immunol 123:1244-52.e2. 2009
    Psoriasis and atopic dermatitis (AD) are common inflammatory skin diseases. An upregulated TH17/IL-23 pathway was demonstrated in psoriasis...
  87. ncbi TSLP: finally in the limelight
    Warren J Leonard
    Nat Immunol 3:605-7. 2002
  88. ncbi Involuntary autonomy: patients' perceptions of physicians, conventional medicines and risks in the management of atopic dermatitis
    Mikkel Noerreslet
    University of Copenhagen, The Faculty of Pharmaceutical Sciences, Department of Pharmacology and Pharmacotherapy, Universitetsparken 2, 2100 Copenhagen, Denmark
    Soc Sci Med 69:1409-15. 2009
    ..In-depth interviews were carried out with 24 people who medically managed their own or their child's atopic dermatitis. The informants were recruited via the Division of Dermatology in a Danish Hospital which was planning an ..
  89. ncbi Long-term management of atopic dermatitis in infants with topical pimecrolimus, a nonsteroid anti-inflammatory drug
    Alexander Kapp
    Department of Dermatology and Allergology, Hannover Medical University, Ricklingerstrasse 5, D 30449 Hannover, Germany
    J Allergy Clin Immunol 110:277-84. 2002
    ..SDZ ASM 981), a nonsteroid selective inhibitor of inflammatory cytokines, is effective in the treatment of atopic dermatitis (AD)...
  90. ncbi The epidermal barrier in atopic dermatitis
    Jeffrey L Sugarman
    Departments of Dermatology and Family Medicine, University of California, San Francisco, CA, USA
    Semin Cutan Med Surg 27:108-14. 2008
    Epidermal barrier function is abnormal in individuals with atopic dermatitis (AD)...
  91. ncbi Filaggrin null mutations are associated with atopic dermatitis and elevated levels of IgE in the Japanese population: a family and case-control study
    Hisako Enomoto
    Department of Medical Genetics, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1 1 1 Tennodai, Tsukuba, Ibaraki, Japan
    J Hum Genet 53:615-21. 2008
    ..gene have been identified in patients with ichthyosis vulgaris, and these null mutations are associated with atopic dermatitis (AD) development...
  92. ncbi IL-5 and IL-5 receptor alpha polymorphisms are associated with atopic dermatitis in Koreans
    J H Namkung
    Department of Dermatology, Sungkyunkwan University School of Medicine, Samsung Medical Center, Seoul, Korea
    Allergy 62:934-42. 2007
    Eosinophils are recruited into the affected tissue of asthma and atopic dermatitis (AD) patients. IL-5 and IL-5R are highly expressed in the AD skin lesions, yet the reported levels of IL-8 are controversial.
  93. ncbi The Copenhagen Prospective Study on Asthma in Childhood (COPSAC): design, rationale, and baseline data from a longitudinal birth cohort study
    Hans Bisgaard
    Department of Pediatrics, Copenhagen University Hospital, Copenhagen, Denmark
    Ann Allergy Asthma Immunol 93:381-9. 2004
    The atopic diseases asthma, atopic dermatitis, and allergic rhinitis are the most common chronic diseases in children, and their prevalence has increased recently in industrialized nations...
  94. ncbi Polarized in vivo expression of IL-11 and IL-17 between acute and chronic skin lesions
    Masao Toda
    Meakins Christie Laboratories, McGill University, Montreal, Canada
    J Allergy Clin Immunol 111:875-81. 2003
    In atopic dermatitis (AD) there is evidence of tissue fibrosis involving a number of structural changes, including papillary dermal fibrosis and epidermal hyperplasia...
  95. pmc Superantigen profile of Staphylococcus aureus isolates from patients with steroid-resistant atopic dermatitis
    Patrick M Schlievert
    Department of Microbiology, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Clin Infect Dis 46:1562-7. 2008
    Superantigens induce skin inflammatory responses in atopic dermatitis, which is commonly associated with Staphylococcus aureus infection. T cells activated in vitro by superantigens become steroid resistant...
  96. ncbi Probiotics in primary prevention of atopic dermatitis
    Geun Eog Ji
    Department of Food and Nutrition, Seoul National University, Seoul, South Korea
    Forum Nutr 61:117-28. 2009
    ..Lactobacillus, and Lactococcus have been assessed for their ability to suppress the occurrence of atopic dermatitis (AD) in animal models and human studies...
  97. ncbi Decreased levels of sphingosine, a natural antimicrobial agent, may be associated with vulnerability of the stratum corneum from patients with atopic dermatitis to colonization by Staphylococcus aureus
    Junko Arikawa
    Department of Dermatology, Tokyo Women s Medical University, Tokyo, Japan Kao Biological Science Laboratories, Tochigi, Japan
    J Invest Dermatol 119:433-9. 2002
    The stratum corneum of the skin of patients with atopic dermatitis is highly susceptible to colonization by various bacteria, including Staphylococcus aureus...
  98. ncbi The skin barrier, atopic dermatitis and allergy: a role for Langerhans cells?
    Robin E Callard
    Immunobiology Unit, Institute of Child Health, University College London, London, UK, WC1N 1EH
    Trends Immunol 28:294-8. 2007
    ..Genetic abnormalities in skin barrier function are associated with allergy and atopic dermatitis, and removal of the skin barrier by tape stripping results in dominant Th2 responses to protein antigens...
  99. ncbi Two common loss-of-function mutations within the filaggrin gene predispose for early onset of atopic dermatitis
    Susanne Stemmler
    J Invest Dermatol 127:722-4. 2007
  100. ncbi A GeNorm algorithm-based selection of reference genes for quantitative real-time PCR in skin biopsies of healthy dogs and dogs with atopic dermatitis
    Yvette M Schlotter
    Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands
    Vet Immunol Immunopathol 129:115-8. 2009
    ..Healthy dogs (n=7) and dogs with confirmed atopic dermatitis (n=28) were included. Lesional and non-lesional skin was analyzed...
  101. ncbi International Consensus Conference on Atopic Dermatitis II (ICCAD II): clinical update and current treatment strategies
    C Ellis
    Department of Dermatology, University of Michigan Medical Center, Ann Arbor, MI, U S A
    Br J Dermatol 148:3-10. 2003

Research Grants69

  1. ASTHMA AND ALLERGIC DISEASE CENTER
    Thomas A Platts Mills; Fiscal Year: 2010
    ..investigation of the link between these cells and IgE by monitoring circulating T cells in children with atopic dermatitis during the first years of life, and examining the effects of anti-lgE therapy on discrete T cell subsets in ..
  2. Targeting Galectin-3 with novel drugs for treatment of eczema
    Fu Tong Liu; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: Atopic dermatitis is a common chronic inflammatory skin disease...
  3. Bi-functional Therapeutics for Allergy-BFTA
    Swey Shen Chen; Fiscal Year: 2010
    ..diseases, afflicting 25% of the US population, are manifested as allergic asthma, rhinitis, food allergy, atopic dermatitis, and anaphylaxis...
  4. Regulation/Role of AcylCer in Normal Epidermis and Atopic Dermatitis
    Peter M Elias; Fiscal Year: 2013
    ..Importantly, a selective deficiency in acylCer occurs in atopic dermatitis (AD), which could further aggravate inherent defects in SC structures...
  5. Galectin-3 in regulation of allergic skin inflammation
    Fu Tong Liu; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Atopic dermatitis is a common chronic inflammatory skin disease. It is a significant medical problem and as much as 15-20% of children are affected by this disease in industrialized countries...
  6. Perinatal Programming of Infant Stress Reactivity and the Atopic Phenotype
    Rosalind J Wright; Fiscal Year: 2013
    ..is a fundamental feature of atopy, predisposing individuals to a spectrum of disorders, allergic rhinitis, atopic dermatitis, and allergic asthma...
  7. Protective orthopox immunization in normals and patients with cancer or eczema
    Ellis Reinherz; Fiscal Year: 2009
    ..the Harvard Skin Disease Research Center will examine human skin elements of orthopox vaccinated normals or atopic dermatitis patients for productive viral infection, and compare and contrast the nature of central memory and skin ..
  8. Regulation of TSLP receptor expression and function in eczema in mice and man
    Steven F Ziegler; Fiscal Year: 2013
    ..lymphopoietin (TSLP), has been implicated in the pathogenesis of the chronic inflammatory skin condition, atopic dermatitis (AD)...
  9. Cytokine Signaling in Neurons: Inflammation, Pain and Pruritis
    Martin Steinhoff; Fiscal Year: 2013
    ..pruritus, sensory nerves play an essential role in the initiation or aggravation of chronic diseases like atopic dermatitis, inflammatory bowel disease, irritable bowel syndrome, asthma, and rheumatoid arthritis...
  10. The consequences of loricrin deficiency on epidermal barrier function
    DENNIS ROOP; Fiscal Year: 2013
    ..Finally, atopic dermatitis (AD) is a chronic, reoccurring skin disease that causes dry, itchy, inflamed skin, affecting 15-30% of ..
  11. Pregnancy Folate Status &Early Childhood Respiratory &Atopic Disease Outcomes
    KECIA NICOLE CARROLL; Fiscal Year: 2013
    ..folate status using objective measures and will assess childhood wheezing, asthma, allergic rhinitis, and atopic dermatitis using validated tools and objective measures...
  12. GILT and regulation of Treg development in cutaneous autoimmunity
    KAREN TARASZKA HASTINGS; Fiscal Year: 2013
    ..role in the prevention of cutaneous autoimmune and inflammatory diseases, such as vitiligo, psoriasis, atopic dermatitis and systemic lupus erythematosus...
  13. Characterization of Enhancers in the Epidermal Differentiation Complex
    CRISTINA DE GUZMAN STRONG; Fiscal Year: 2012
    b>Atopic dermatitis (AD) and psoriasis are two inflammatory skin diseases that affect over 22.5 million Americans collectively and are burdening the U.S. economy with over $7.5 billion dollars in management and quality-of-life issue costs...
  14. Nature of mamalian Cutaneous Permeablilty Barrier
    Peter M Elias; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Atopic dermatitis (AD) is an increasingly common disease of uncertain etiology...
  15. Mechanisms used by skin dendritic cells to induce regulatory T cells
    Juliana Idoyaga; Fiscal Year: 2013
    ..e., atopic dermatitis, psoriais, contact dermatitis, and pemphigus vulgaris...
  16. Mechanism of CTIP2 action in mouse epidermal homeostasis and barrier formation,
    ARUP K INDRA; Fiscal Year: 2012
    ..believed to contribute to several hereditary and acquired inflammatory skin disorders, such as psoriasis and atopic dermatitis (AD). Thus, understanding the pathways that are controlled by different regulatory proteins (e.g...
  17. TSLP and Childhood Asthma
    Steven F Ziegler; Fiscal Year: 2012
    ..provided by applicant): The atopic diseases consist of the triad of asthma, allergic rhinitis, and atopic dermatitis. These diseases share a common pathogenesis, involving inflammatory Th2-type cytokines and elevated IgE...
  18. Skin Defense by Antimicrobial Peptides
    Richard L Gallo; Fiscal Year: 2012
    ..We have discovered much about the etiology of rosacea and why patients with atopic dermatitis are susceptible to infection...
  19. Dermatotropic cellular immune responses induced by a novel smallpox vaccine
    Stephen R Walsh; Fiscal Year: 2013
    ..magnitude, and trafficking marker expression of orthopoxvirus-specific T cells in subjects with eczema or atopic dermatitis vaccinated with MVA...
  20. Trim32 Regulation of Piasy in Skin Homeostasis
    Molly F Kulesz-Martin; Fiscal Year: 2013
    ..of epidermal hyperplasia because its elevation in psoriasis, recognized as a Th17 disease, is not shared by atopic dermatitis, recognized as a Th2 cell disease, and because upregulation of CCL20 in keratinocytes responds to Th17 but ..
  21. Bupropion for Depression in ESRD Patients on Hemodialysis
    Pedro L Delgado; Fiscal Year: 2013
    ..in laboratory animals and humans and has been shown to reduce inflammation and improve mood in patients with atopic dermatitis. Therefore, bupropion has the potential to be exceptionally therapeutic in ESRD/HD...
  22. TIM recognition of phosphatidylserine regulates innate and adaptive immunity
    Dale T Umetsu; Fiscal Year: 2013
    ..instructions): The 7//W genes have been shown to be important disease susceptibility genes (asthma, allergy, atopic dermatitis, food allergy and rheumatoid arthritis) and to potently regulate immune responses...
  23. Recruiting Rural Parents/Infants to Health Research Projects: Atopic Dermatitis
    Steven R Feldman; Fiscal Year: 2010
    ..goal is to conduct a research project that delineates gene-environment interactions in the prevalence of atopic dermatitis (AD)...
  24. The Role of bacterial toxins in human skin disease.
    DONALD YM LEUNG; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Atopic dermatitis (AD) is a pruritic chronic inflammatory skin disease associated with significant morbidity and occupational disability affecting 17% of children and nearly 2% of adults in the U.S...
  25. Short Wavelength UV Sources for Treatment of Psoriasis
    JOSEPH SMART; Fiscal Year: 2006
    ..new phototherapy treatment programs for psoriasis and possibly other skin diseases including acne vularis, atopic dermatitis, vitiligo, pruritus, lichen planus, pityriasis rosea and early cutaneous T-cell lymphoma...
  26. Genetic Heterogeniety of the Hyper IgE Syndrome
    TALAL AMINE CHATILA; Fiscal Year: 2010
    ..by which genetic factors contribute to inflammation and immunodeficiency, and will help identify novel therapeutic approaches relevant to both this disorder and more common allergic inflammatory diseases such as atopic dermatitis.
  27. 2011 Antimicrobial Peptides Gordon Research Conference
    Nita H Salzman; Fiscal Year: 2011
    ..of human diseases, including inflammatory bowel disease, sexually transmitted and opportunistic infections, atopic dermatitis, and others. The program will be divided into 9 sessions of oral presentations and two poster sessions...
  28. Effect of the PPAR Agonist Pioglitazone on Epidermal Barrier in Atopic Dermatitis
    LISA ANN BECK; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Atopic dermatitis (AD) is the most common inflammatory disorder of the skin and is initiated by Th2-driven inflammation in response to environmental allergens...
  29. 2013 Antimicrobial Peptides GRC/GRS
    Gill Diamond; Fiscal Year: 2013
    ..of human diseases, including inflammatory bowel disease, sexually transmitted and opportunistic infections, atopic dermatitis, and others. The program will be divided into 9 sessions of oral presentations and four poster sessions...
  30. Defining mechanisms for how Ndfip1 regulates T cell-mediated allergic responses
    ALLISON MARIE BEAL; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Atopic diseases, such as asthma, atopic dermatitis (AD), and inflammatory bowel disease (IBD), are among the most common chronic childhood illnesses and a frequent cause of pediatric hospitalization...
  31. Nedd4-family adaptors and their regulation of T cell function.
    PAULA MARIA OLIVER; Fiscal Year: 2013
    ..within the locus that encodes Ndfip1 (located on human Chr5) that are more common in patients with asthma, atopic dermatitis (AD) and inflammatory bowel disease (IBD)2, thus supporting that Ndfip1 regulates atopic disease in both ..
  32. The Peripheral and Central Neuronal Circuits that Underlie Itch
    Hyosang Lee; Fiscal Year: 2012
    ..one the most distressing of dermatological symptoms, is associated with numerous skin diseases, such as atopic dermatitis, as well as with extracutaneous disorders...
  33. TSLP and the Pathophysiology of Asthma
    Steven F Ziegler; Fiscal Year: 2013
    ..provided by applicant): The atopic diseases consist of the triad of asthma, allergic rhinitis, and atopic dermatitis. These diseases share a common pathogenesis, involving inflammatory Th2-type cytokines and elevated IgE...
  34. TSLP in Th2 Immunity and Allergic Airway Inflammation
    Baohua Zhou; Fiscal Year: 2013
    ..TSLP is critical in the pathogenesis of asthma and atopic dermatitis as studies in our lab demonstrated that mice deficient in TSLP receptor is greatly impaired in allergic ..
  35. Melanocyte-Keratinocyte Cross-Talk In Relation To Barrier Function
    Peter M Elias; Fiscal Year: 2013
    ..skin should be inherently more at risk for development of inflammatory skin disorders, such as atopic dermatitis and adult eczemas, well as all types of skin infections...
  36. Ultrasensitive Detection Probes for Staphylococcus aureus Enterotoxins
    David M Kranz; Fiscal Year: 2012
    ..are associated with food-borne illnesses, pulmonary disease, pneumonia, toxic shock syndrome, exacerbated atopic dermatitis, delayed wound healing, and infectious endocarditis...
  37. Hyaluronan in Epidermal Injury Responses
    Edward Maytin; Fiscal Year: 2009
    ..Abnormal response to barrier injury are involved in pathologic skin conditions, including atopic dermatitis, corn and callus formation, and hypertrophic thickening at the edge of chronic wounds...
  38. VDAART FLORA ANCILLARY STUDY
    Diane R Gold; Fiscal Year: 2013
    ..Infant gut diversity was protective against atopic dermatitis in the first 6 months of life...
  39. TSLP and Contact Hypersensitivity
    Steven F Ziegler; Fiscal Year: 2012
    b>Atopic dermatitis and allergic contact hypersensitivity are common inflammatory diseases of the skin for which disease mechanisms are largely unknown...
  40. The Role of the Skin Barrier in Atopic Dermatitis Development and Prevention
    Eric L Simpson; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): There are no generally accepted strategies for the prevention of atopic dermatitis (AD) and other atopic diseases...
  41. A Novel Class of Therapeutic Agents for the Treatment of Skin Diseases Associated
    Joel S Gordon; Fiscal Year: 2010
    ..g. atopic dermatitis, seborrheic dermatitis) and rosacea...
  42. Innate vs Adaptive Contributions to Th2 Pathology in Wiskott Aldrich Syndrome
    Deborah J Fowell; Fiscal Year: 2012
    ..In contrast, WAS patients exhibit increased IgE levels and atopic dermatitis/eczema...
  43. Regulation of TSLP-Mediated Skin Inflammation
    Steven F Ziegler; Fiscal Year: 2013
    ..psoriasis, scleroderma and pemphigus vulgaris, as well as allergic responses that lead to acute and chronic atopic dermatitis (AD) and allergic contact dermatitis (ACD)...
  44. Sphingosine-1-Phosphate, A Novel Mediator of Human Skin Mass Cell Functions
    Carole A Oskeritzian; Fiscal Year: 2010
    ..Hypersensitivity to environmental stimuli is a fundamental feature of atopy that manifests itself through atopic dermatitis or eczema. Mast cells are distributed widely in the skin and increased in number in atopic dermatitis (AD)...
  45. Role of Il-13 Receptors in Atopic Dermatitis
    Gurjit K Khurana Hershey; Fiscal Year: 2011
    b>Atopic dermatitis (AD), a chronic relapsing inflammatory skin disease, is a major public health problem affecting 9-20% of the population of the United States...
  46. Self-Injurious Behavior and Primate Well-Being
    MELINDA ANN NOVAK; Fiscal Year: 2011
    ..captive primates can result from several different factors, including hair plucking, stress and anxiety, and atopic dermatitis. PUBLIC HEALTH RELEVANCE (provided by applicant): This research is designed to improve the quality of the ..
  47. Linking Lipoxygenases with Essential Fatty Acids and Epidermal Barrier Formation
    Alan R Brash; Fiscal Year: 2013
    ..the water impermeable barrier of the epidermis, defects in which result in ichthyoses and contribute to atopic dermatitis. 12R-Lipoxygenase (12R-LOX) and Epidermal Lipoxygenase-3 (eLOX3) are the only human lipoxygenases that, if ..
  48. Mechanistic Analysis of Anti-inflammatory Activity by Fluorosugars
    Charles J Dimitroff; Fiscal Year: 2012
    ..To this end, controlling the migration of skin-homing leukocytes associated with skin disorders, such as atopic dermatitis, allergic dermatitis, psoriasis and cutaneous leukemias, with selectin ligand-modifying sugar mimetics ..
  49. Filaggrin Mutations and the Prognosis of Atopic Dermatitis
    David J Margolis; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Atopic dermatitis (AD) is a highly pruritic chronic inflammatory skin disease that predominantly presents during infancy but may also present during childhood or adulthood...
  50. EARLY LIFE VITAMIN D, RACIAL DISPARITIES, AND WHEEZING
    GANESA REBECCA WEGIENKA; Fiscal Year: 2013
    ..testing (SPT) and total and specific serum IgE (sIgE) concentration, as well as wheeze and doctor-diagnosed atopic dermatitis at age 2 years in an already established racially diverse birth cohort...
  51. IL-13 Atopic Dermatitis and Its Relationship with the Development of Asthma
    Tao Zheng; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Atopic dermatitis (AD) has been proposed as the cutaneous manifestation of a systemic disorder that also gives rise to asthma and allergic rhinitis, the so-called "atopic march"...
  52. A Study of ILV-94 (Anti-22 Antibody) Administered via IV in Atopic Dermatitis
    Emma Guttman; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Atopic dermatitis (AD) is the most common inflammatory skin disorder, affecting up to 3-4% of adults and 25% of the children, most of which are part of the moderate-to-severe AD category, and which ..
  53. Linking Nicotinic Activation with Skin Innate Immunity and Atopic Dermatitis
    KATHERINE AMANDA RADEK; Fiscal Year: 2013
    ..evaluate the AMP profile altered by nAChR activation, and link this mechanism to the pathogenesis of Atopic Dermatitis (AD)...
  54. Self-Injurious Behavior and Primate Well-Being
    MELINDA ANN NOVAK; Fiscal Year: 2013
    ..enlarged the scope of this project to include hair loss, and we will test the hypothesis that hair loss in captive primates can result from several different factors, including hair plucking, stress and anxiety, and atopic dermatitis.
  55. Control of airway inflammation and Th2 differentiation by microRNA 21
    Alexander L Dent; Fiscal Year: 2012
    ..presenting with atopic diseases including asthma, rhino- conjunctivitis, sinusitis, food allergy, and atopic dermatitis. Thus, new diagnostic markers and treatments for allergic diseases remain a high priority...
  56. Epithelial Barrier Programs in Asthma and Allergic Disease
    Michael J Holtzman; Fiscal Year: 2013
    ..and allergic asthma (Project 2), and third, how epithelial injury in the skin triggers the march from atopic dermatitis to asthma (Project 3)...
  57. ROLE OF MAST CELLS IN INFLAMMATION AND IMMUNITY
    STEPHEN JOSEPH GALLI; Fiscal Year: 2010
    ..widely regarded to be the main process by which MCs contribute significantly to allergic disorders such as atopic dermatitis &atopic asthma...
  58. Immune Response to Cat: Regulatory and Effector T Cells
    Judith A Woodfolk; Fiscal Year: 2013
    ..by applicant): Understanding the role that T cells play in the chronic allergic inflammatory skin disorder, atopic dermatitis (AD), is highly relevant to the development of specific treatments for this debilitating disease...
  59. Cytokine regulation of skin barrier function
    Mark H Kaplan; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Skin inflammation in Atopic Dermatitis (AD) patients includes dendritic cells, mast cells and T cells...
  60. The mechanism of thymic stromal lymphopoietin overexpression by epithelial cells
    Shadmehr Demehri; Fiscal Year: 2010
    Asthma and atopic dermatitis are the two major allergic diseases, which are caused by chronic inflammation affecting lung airways and skin, respectively...
  61. Epithelial Genes In Allergic Inflammation
    Gurjit K Khurana Hershey; Fiscal Year: 2013
    ..e. lung (asthma), skin (atopic dermatitis), or gut (food allergy or eosinophilic esophagitis)...
  62. Gene Responses in Basophil-Mediated Allergic Responses
    Hua Huang; Fiscal Year: 2013
    ..by applicant):The incidence and mortality of allergic diseases, such as anaphylaxis, allergic rhinitis, atopic dermatitis and asthma, have increased at an alarming rate in the Western countries in the past several decades...
  63. Development of Topical Neuroinflammatory Inhibitors
    MANDIP SACHDEVA; Fiscal Year: 2005
    ..Certain skin diseases such as psoriasis, contact dermatitis and atopic dermatitis may have a significant neurogenic component...
  64. ANTIGENIC STRUCTURE OF PURIFIED HOUSE DUST MITE ALLERGEN
    Martin Chapman; Fiscal Year: 1992
    ..mites (Dermatophagoides) are an important cause of allergic diseases such as perennial rhinitis, asthma and atopic dermatitis and the two principal species, D. pteronyssinus and D...
  65. Novel Topical Treatment of Eczema
    Bakul Bhatt; Fiscal Year: 2006
    ..homeostasis for skin conditions including hypertrophic scars and keloids, inflammatory dermatoses such as atopic dermatitis and psoriasis, disorders of keratinization, and eczema...
  66. Risk Factors for Eczema Vaccinatum in Atopic Dermatitis
    Walter Holleran; Fiscal Year: 2009
    ..complication of the Vaccinia vaccine, stringent criteria have excluded persons who currently suffer from atopic dermatitis (AD), or who have previously suffered from AD, and even close contacts of persons who have AD, from ..
  67. MOLECULAR BASIS OF T CELL HOMING TO INFLAMED SKIN
    Louis Picker; Fiscal Year: 1999
    ..in the pathogenesis of chronic inflammatory skin diseases, such as allergic contact dermatitis (ACD), atopic dermatitis (AD)...
  68. Pre-clinical Studies on Lupinus termis Seeds Extract
    MIKHAIL ANTOUN; Fiscal Year: 2003
    b>Atopic dermatitis is a skin condition that affects an estimated 10-20 percent of the population...
  69. EVALUATION OF BASOPHIL INVOLVEMENT IN HUMAN DISEASE
    Lawrence Schwartz; Fiscal Year: 2001
    ..and deposits of activated basophils will be examined in human tissues using the 2D7 mAb, including skin in atopic dermatitis, chronic urticaria, and urticaria pigmentosa, nasal mucosa in allergic rhinitis and lung in asthma...