fetal alcohol syndrome

Summary

Summary: A condition occurring in FETUS or NEWBORN due to in utero ETHANOL exposure when mother consumed alcohol during PREGNANCY. It is characterized by a cluster of irreversible BIRTH DEFECTS including abnormalities in physical, mental, and behavior development (such as FETAL GROWTH RETARDATION; MENTAL RETARDATION; ATTENTION DEFICIT AND DISRUPTIVE BEHAVIOR DISORDERS) with varied degree of severity in an individual.

Top Publications

  1. ncbi Prevalence and epidemiologic characteristics of FASD from various research methods with an emphasis on recent in-school studies
    Philip A May
    Department of Sociology, The University of New Mexico, Albuquerque, New Mexico, USA
    Dev Disabil Res Rev 15:176-92. 2009
  2. pmc Fetal alcohol spectrum disorder: Canadian guidelines for diagnosis
    Albert E Chudley
    Children s Hospital, Health Sciences Centre, Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Man
    CMAJ 172:S1-S21. 2005
  3. ncbi Paediatricians' knowledge, attitudes and practice following provision of educational resources about prevention of prenatal alcohol exposure and Fetal Alcohol Spectrum Disorder
    Janet M Payne
    Telethon Institute for Child Health Research, Centre for Child Health Research, The University of Western Australia, Perth, Australia
    J Paediatr Child Health 47:704-10. 2011
  4. ncbi Development of Canadian screening tools for fetal alcohol spectrum disorder
    Y Ingrid Goh
    The Motherisk Program, Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, Toronto, Ontario
    Can J Clin Pharmacol 15:e344-66. 2008
  5. ncbi Fetal alcohol syndrome: a prospective national surveillance study
    E J Elliott
    Discipline of Paediatrics andChild Health, University of Sydney, The Children s Hospital at Westmead and The Australian Paediatric Surveillance Unit, Westmead, NSW, Australia
    Arch Dis Child 93:732-7. 2008
  6. ncbi Risk factors for adverse life outcomes in fetal alcohol syndrome and fetal alcohol effects
    Ann P Streissguth
    Department of Psychiatry and Behavioral Sciences, Fetal Alcohol and Drug Unit, University of Washington School of Medicine, Seattle, Washington 98195, USA
    J Dev Behav Pediatr 25:228-38. 2004
  7. pmc The epidemiology of fetal alcohol syndrome and partial FAS in a South African community
    Philip A May
    Department of Sociology and Family and Community Medicine, The University of New Mexico, Center on Alcoholism, Substance Abuse and Addictions, 2650 Yale Blvd SE, Albuquerque, NM 87106, USA
    Drug Alcohol Depend 88:259-71. 2007
  8. pmc A practical clinical approach to diagnosis of fetal alcohol spectrum disorders: clarification of the 1996 institute of medicine criteria
    H Eugene Hoyme
    Department of Pediatrics, Division of Medical Genetics, H 315, Stanford University School of Medicine, Stanford, CA 94305 5208, USA
    Pediatrics 115:39-47. 2005
  9. ncbi Profile of the first 1,400 patients receiving diagnostic evaluations for fetal alcohol spectrum disorder at the Washington State Fetal Alcohol Syndrome Diagnostic & Prevention Network
    Susan J Astley
    Department of Epidemiology, University of Washington, Seattle, WA, USA
    Can J Clin Pharmacol 17:e132-64. 2010
  10. ncbi Fetal alcohol spectrum disorder
    Robert J Sokol
    C S Mott Center for Human Growth and Development, Children s Research Center, and Department of Obstetrics and Gynecology, Wayne State University, Detroit, Mich 48201, USA
    JAMA 290:2996-9. 2003

Detail Information

Publications287 found, 100 shown here

  1. ncbi Prevalence and epidemiologic characteristics of FASD from various research methods with an emphasis on recent in-school studies
    Philip A May
    Department of Sociology, The University of New Mexico, Albuquerque, New Mexico, USA
    Dev Disabil Res Rev 15:176-92. 2009
    Researching the epidemiology and estimating the prevalence of fetal alcohol syndrome (FAS) and other fetal alcohol spectrum disorders (FASD) for mainstream populations anywhere in the world has presented a challenge to researchers...
  2. pmc Fetal alcohol spectrum disorder: Canadian guidelines for diagnosis
    Albert E Chudley
    Children s Hospital, Health Sciences Centre, Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Man
    CMAJ 172:S1-S21. 2005
    ..assessment; and treatment and follow-up; maternal alcohol history in pregnancy; diagnostic criteria for fetal alcohol syndrome (FAS), partial FAS and alcohol-related neurodevelopmental disorder; and harmonization of Institute of ..
  3. ncbi Paediatricians' knowledge, attitudes and practice following provision of educational resources about prevention of prenatal alcohol exposure and Fetal Alcohol Spectrum Disorder
    Janet M Payne
    Telethon Institute for Child Health Research, Centre for Child Health Research, The University of Western Australia, Perth, Australia
    J Paediatr Child Health 47:704-10. 2011
    ..about the prevention of prenatal alcohol exposure and fetal alcohol spectrum disorder, and assess changes in their knowledge, attitudes and practice about fetal alcohol syndrome (FAS) and alcohol consumption in pregnancy.
  4. ncbi Development of Canadian screening tools for fetal alcohol spectrum disorder
    Y Ingrid Goh
    The Motherisk Program, Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, Toronto, Ontario
    Can J Clin Pharmacol 15:e344-66. 2008
    ..Screening for FASD may facilitate diagnosis and hence management of these children. We present a variety of screening tools for the identification of children at risk for FASD...
  5. ncbi Fetal alcohol syndrome: a prospective national surveillance study
    E J Elliott
    Discipline of Paediatrics andChild Health, University of Sydney, The Children s Hospital at Westmead and The Australian Paediatric Surveillance Unit, Westmead, NSW, Australia
    Arch Dis Child 93:732-7. 2008
    To describe the epidemiology of cases of fetal alcohol syndrome (FAS) seen by Australian paediatricians.
  6. ncbi Risk factors for adverse life outcomes in fetal alcohol syndrome and fetal alcohol effects
    Ann P Streissguth
    Department of Psychiatry and Behavioral Sciences, Fetal Alcohol and Drug Unit, University of Washington School of Medicine, Seattle, Washington 98195, USA
    J Dev Behav Pediatr 25:228-38. 2004
    Clinical descriptions of patients with Fetal Alcohol Syndrome (FAS) and Fetal Alcohol Effects (FAE) suggest major problems with adaptive behavior...
  7. pmc The epidemiology of fetal alcohol syndrome and partial FAS in a South African community
    Philip A May
    Department of Sociology and Family and Community Medicine, The University of New Mexico, Center on Alcoholism, Substance Abuse and Addictions, 2650 Yale Blvd SE, Albuquerque, NM 87106, USA
    Drug Alcohol Depend 88:259-71. 2007
    The prevalence and characteristics of fetal alcohol syndrome (FAS) and partial fetal alcohol syndrome (PFAS) were determined in a third primary school cohort in a community in South Africa (SA).
  8. pmc A practical clinical approach to diagnosis of fetal alcohol spectrum disorders: clarification of the 1996 institute of medicine criteria
    H Eugene Hoyme
    Department of Pediatrics, Division of Medical Genetics, H 315, Stanford University School of Medicine, Stanford, CA 94305 5208, USA
    Pediatrics 115:39-47. 2005
    ..Although both approaches have improved the clinical delineation of FASD, both suffer from significant drawbacks in their practical application in pediatric practice...
  9. ncbi Profile of the first 1,400 patients receiving diagnostic evaluations for fetal alcohol spectrum disorder at the Washington State Fetal Alcohol Syndrome Diagnostic & Prevention Network
    Susan J Astley
    Department of Epidemiology, University of Washington, Seattle, WA, USA
    Can J Clin Pharmacol 17:e132-64. 2010
    ..Diagnostic clinics are being established worldwide. If these clinics are to successfully compete for limited health care dollars, it is essential to document their value...
  10. ncbi Fetal alcohol spectrum disorder
    Robert J Sokol
    C S Mott Center for Human Growth and Development, Children s Research Center, and Department of Obstetrics and Gynecology, Wayne State University, Detroit, Mich 48201, USA
    JAMA 290:2996-9. 2003
  11. ncbi Prevalence of fetal alcohol syndrome in the Top End of the Northern Territory
    K R Harris
    Paediatric Department, Royal Darwin Hospital, Darwin, Northern Territory, Australia
    J Paediatr Child Health 39:528-33. 2003
    To establish the prevalence of fetal alcohol syndrome (FAS) in the Top End of the Northern Territory (NT), Australia, in both the indigenous and non-indigenous populations...
  12. ncbi Brain dysmorphology in individuals with severe prenatal alcohol exposure
    S L Archibald
    Department of Psychiatry, University of California, San Diego 92093 0949, USA
    Dev Med Child Neurol 43:148-54. 2001
    ..Fourteen participants (mean 11.4 years; eight females, six males) with fetal alcohol syndrome (FAS) and 12 participants (mean 14...
  13. pmc Fetal alcohol spectrum disorders: an overview
    Edward P Riley
    Department of Psychology, Center for Behavioral Teratology, San Diego State University, San Diego, CA 92120, USA
    Neuropsychol Rev 21:73-80. 2011
    When fetal alcohol syndrome (FAS) was initially described, diagnosis was based upon physical parameters including facial anomalies and growth retardation, with evidence of developmental delay or mental deficiency...
  14. ncbi Measuring the facial phenotype of individuals with prenatal alcohol exposure: correlations with brain dysfunction
    S J Astley
    Department of Epidemiology, School of Public Health and Community Medicine University of Washington, Seattle, WA 98105, USA
    Alcohol Alcohol 36:147-59. 2001
    The purpose of this report is to demonstrate how to measure the magnitude of expression of the fetal alcohol syndrome (FAS) facial phenotype using the new 4-Digit Diagnostic Code and the previously developed D-score and to demonstrate how ..
  15. pmc Health care burden and cost associated with fetal alcohol syndrome: based on official Canadian data
    Svetlana Popova
    Social and Epidemiological Research Department, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    PLoS ONE 7:e43024. 2012
    ..From this group, Fetal Alcohol Syndrome (FAS) is the only disorder coded in the International Classification of Diseases, version 10 (ICD-10)...
  16. pmc Maternal risk factors for fetal alcohol syndrome in the Western cape province of South Africa: a population-based study
    Philip A May
    The University of New Mexico, Center on Alcoholism, Substance Abuse and Addictions, 2650 Yale Blvd SE, Albuquerque, NM 87106, USA
    Am J Public Health 95:1190-9. 2005
    We defined risk factors for fetal alcohol syndrome (FAS) in a region with the highest documented prevalence of FAS in the world.
  17. ncbi Apoptotic neurodegeneration induced by ethanol in neonatal mice is associated with profound learning/memory deficits in juveniles followed by progressive functional recovery in adults
    David F Wozniak
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Neurobiol Dis 17:403-14. 2004
    ..This neurotoxicity may explain the reduced brain mass and neurobehavioral disturbances in human Fetal Alcohol Syndrome (FAS)...
  18. ncbi What do we know about the economic impact of fetal alcohol spectrum disorder? A systematic literature review
    Svetlana Popova
    Social and Epidemiological Research Department, Centre for Addiction and Mental Health, Toronto, ON, Canada
    Alcohol Alcohol 46:490-7. 2011
    ..The objective of this study was to conduct a systematic review of the literature related to the measurement of the economic impact of Fetal Alcohol Spectrum Disorder (FASD) in different countries and to categorize the available literature...
  19. ncbi Changes in health professionals' knowledge, attitudes and practice following provision of educational resources about prevention of prenatal alcohol exposure and fetal alcohol spectrum disorder
    Janet Payne
    Telethon Institute for Child Health Research, University of Western Australia, Subiaco, WA, Australia
    Paediatr Perinat Epidemiol 25:316-27. 2011
    ..fetal alcohol spectrum disorder and assessed changes in their knowledge, attitudes and practice concerning fetal alcohol syndrome (FAS) and alcohol consumption in pregnancy...
  20. ncbi A comparison of the effects of parental risk markers on pre- and perinatal variables in multiple patient cohorts with fetal alcohol syndrome, autism, Tourette syndrome, and sudden infant death syndrome: an enviromic analysis
    Marilyn G Klug
    North Dakota Fetal Alcohol Syndrome Center, School of Medicine and Health Sciences, University of North Dakota, Box 9037, 501 N Columbia Road, Grand Forks, ND 58202 9037, USA
    Neurotoxicol Teratol 25:707-17. 2003
    ..The four study cohorts for this project were patients from four diagnostic registries in North Dakota for fetal alcohol syndrome (FAS), autism, sudden infant death syndrome (SIDS), and Tourette syndrome...
  21. ncbi The Canadian guidelines and the interdisciplinary clinical capacity of Canada to diagnose fetal alcohol spectrum disorder
    Sterling K Clarren
    Neurodevelopment Network Canada NeuroDevNet, The Canada Northwest FASD Research Network Developmental Neurosciences and Child Health, Child and Family Research Institute, Vancouver, BC
    J Popul Ther Clin Pharmacol 18:e494-9. 2011
    ..Six years later, we wondered how successfully these Guidelines had been in bringing consistency to FASD clinical work...
  22. pmc The plausibility of maternal nutritional status being a contributing factor to the risk for fetal alcohol spectrum disorders: the potential influence of zinc status as an example
    Carl L Keen
    Department of Nutrition, University of California, Davis, Davis, CA 95616, USA
    Biofactors 36:125-35. 2010
    ....
  23. ncbi Psychiatric conditions associated with prenatal alcohol exposure
    MARY J O'CONNOR
    Department of Psychiatry and Biobehavioral Sciences, Semel Institute of Neuroscience and Human Behavior, David Geffen School of Medicine at UCLA, Los Angeles, California 90024, USA
    Dev Disabil Res Rev 15:225-34. 2009
    Since the identification of fetal alcohol syndrome (FAS) over 35 years ago, mounting evidence about the impact of maternal alcohol consumption during pregnancy has prompted increased attention to the link between prenatal alcohol exposure ..
  24. pmc Neuroimaging and fetal alcohol spectrum disorders
    Andria L Norman
    Center for Behavioral Teratology, Department of Psychology, San Diego State University, San Diego, California, USA
    Dev Disabil Res Rev 15:209-17. 2009
    ..Continued neuroimaging studies are needed to further advance understanding of the neuroteratogenic effects of alcohol...
  25. pmc Imaging the impact of prenatal alcohol exposure on the structure of the developing human brain
    Catherine Lebel
    Developmental Cognitive Neuroimaging Laboratory, Department of Neurology, University of California, Los Angeles, CA 90095 7332, USA
    Neuropsychol Rev 21:102-18. 2011
    ....
  26. ncbi Cost of fetal alcohol spectrum disorders
    Chuck Lupton
    Fetal Alcohol Spectrum Disorders Center for Excellence, SAMHSA NIH DHHS, 1700 Research Boulevard, Suite 400, Rockville, MD 20850, USA
    Am J Med Genet C Semin Med Genet 127:42-50. 2004
    b>Fetal alcohol syndrome (FAS) is a common identifiable teratogenic cause of mental retardation, neurological deficit, mental disorders, and developmental disabilities...
  27. ncbi Guidelines for identifying and referring persons with fetal alcohol syndrome
    Jacquelyn Bertrand
    National Center on Birth Defects and Developmental Disabilities, 1600 Clifton Road NE, MS E 86, Atlanta, GA 30333, USA
    MMWR Recomm Rep 54:1-14. 2005
    b>Fetal alcohol syndrome (FAS) results from maternal alcohol use during pregnancy and carries lifelong consequences. Early recognition of FAS can result in better outcomes for persons who receive a diagnosis...
  28. ncbi Effects of prenatal alcohol exposure on the hippocampus: spatial behavior, electrophysiology, and neuroanatomy
    R F Berman
    Department of Neurological Surgery, Center for Neuroscience, University of California at Davis, 95616, USA
    Hippocampus 10:94-110. 2000
    Prenatal exposure to alcohol can result in fetal alcohol syndrome (FAS), characterized by growth retardation, facial dysmorphologies, and a host of neurobehavioral impairments...
  29. pmc Zebrafish fetal alcohol syndrome model: effects of ethanol are rescued by retinoic acid supplement
    James A Marrs
    Department of Biology, Indiana University Purdue University Indianapolis, Indianapolis, IN 46202, USA
    Alcohol 44:707-15. 2010
    ..Morphological evidence also suggests that other characteristic features of FASD (e.g., neural axis patterning) are rescued by RA supplement...
  30. ncbi Characteristics of children who have full or incomplete fetal alcohol syndrome
    Valborg L Kvigne
    Aberdeen Area Indian Health Service, PHS Indian Hospital, Rapid City, South Dakota, USA
    J Pediatr 145:635-40. 2004
    To describe the clinical features and hospitalization rates of American Indian children with full or incomplete fetal alcohol syndrome (FAS).
  31. ncbi Developmental cortical thinning in fetal alcohol spectrum disorders
    Dongming Zhou
    Department of Biomedical Engineering, University of Alberta, Edmonton, Alberta, Canada
    Neuroimage 58:16-25. 2011
    ....
  32. ncbi Determination of maternal-fetal biomarkers of prenatal exposure to ethanol: a review
    X Joya
    Unitat de Recerca Infància i Entorn URIE, IMIM Parc de Salut Mar, Barcelona, Spain
    J Pharm Biomed Anal 69:209-22. 2012
    ..In addition, clinical toxicological applications of these procedures are presented and discussed...
  33. pmc Maternal risk factors predicting child physical characteristics and dysmorphology in fetal alcohol syndrome and partial fetal alcohol syndrome
    Philip A May
    The University of New Mexico, Center on Alcoholism, Substance Abuse, and Addictions CASAA, Albuquerque, NM 87106, USA
    Drug Alcohol Depend 119:18-27. 2011
    Previous research in South Africa revealed very high rates of fetal alcohol syndrome (FAS), of 46-89 per 1000 among young children...
  34. pmc Do women change their drinking behaviors while trying to conceive? An opportunity for preconception counseling
    Suzanne Tough
    Department of Pediatrics, University of Calgary, Calgary, AB, Canada
    Clin Med Res 4:97-105. 2006
    ..exposure is a leading cause of preventable mental retardation and developmental disabilities, including fetal alcohol syndrome. Current medical guidelines recommend that no alcohol should be consumed over the period of conception and ..
  35. ncbi The effects of alcohol on fetal development
    Kenneth Lyons Jones
    Department of Pediatrics, Division of Dysmorphology Teratology, University of California, San Diego, 92093 0828, USA
    Birth Defects Res C Embryo Today 93:3-11. 2011
    ..Since the initial recognition of the fetal alcohol syndrome (FAS), a number of important observations have been made from studies involving both humans and animals...
  36. pmc Prenatal exposure of ethanol induces increased glutamatergic neuronal differentiation of neural progenitor cells
    Ki Chan Kim
    Department of Pharmacology, College of Pharmacy, Seoul National University, Seoul, Korea
    J Biomed Sci 17:85. 2010
    ....
  37. ncbi Fetal alcohol exposure impairs Hedgehog cholesterol modification and signaling
    Yin Xiong Li
    Division of Gastroenterology, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Lab Invest 87:231-40. 2007
    ..This insight into FASD pathogenesis may suggest novel strategies for preventing these common congenital defects...
  38. ncbi Predictors of risk of alcohol-exposed pregnancies among women in an urban and a rural area of South Africa
    Neo K Morojele
    Medical Research Council, Pretoria, Gauteng, South Africa
    Soc Sci Med 70:534-42. 2010
    ..The significant protective factors were (a) education; (b) knowledge about Fetal Alcohol Syndrome; (c) parity. Use of stricter alcohol use criteria (i.e...
  39. ncbi Building clinical capacity for fetal alcohol spectrum disorder diagnoses in western and northern Canada
    Sterling K Clarren
    The Canada Northwest Fetal Alcohol Spectrum Disorder Research Network Centre for Community Child Health Research, Vancouver, British Columbia
    Can J Clin Pharmacol 15:e223-37. 2008
    b>Fetal alcohol syndrome and fetal alcohol spectrum disorder are common problems. In response to this problem the Canada Northwest FASD Research Network was established in 2005 by the Canada Northwest FASD Ministerial Partnership...
  40. ncbi Need to establish a national diagnostic capacity for foetal alcohol spectrum disorders
    Raewyn Mutch
    Centre for Child Health Research, The University of Western Australia, Perth, WA, Australia
    J Paediatr Child Health 45:79-81. 2009
    ..The University of Washington FASD 4-digit diagnostic code fulfils all of these best practice criteria, recommending itself as the method of choice...
  41. pmc Role of central nervous system insulin resistance in fetal alcohol spectrum disorders
    Suzanne M de la Monte
    Department of Pathology, Rhode Island Hospital and the Warren Alpert School of Medicine at Brown University, Providence, RI, USA
    J Popul Ther Clin Pharmacol 17:e390-404. 2010
    ....
  42. ncbi Fetal alcohol spectrum disorder: counting the invisible - mission impossible?
    Albert E Chudley
    University of Manitoba, Program in Genetics and Metabolism, Children s Hospital, FE 229, 840 Sherbrook Street, Winnipeg, Manitoba R3T 3W6, Canada
    Arch Dis Child 93:721-2. 2008
  43. pmc Health professionals' perceptions about the adoption of existing guidelines for the diagnosis of fetal alcohol spectrum disorders in Australia
    Rochelle E Watkins
    Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, Perth, Australia
    BMC Pediatr 12:69. 2012
    ..In this study we aimed to describe health professionals' perceptions about the adoption of existing guidelines for the diagnosis of FASD in Australia and identify implications for the development of national guidelines...
  44. pmc Alcohol exposure alters DNA methylation profiles in mouse embryos at early neurulation
    Yunlong Liu
    Division of Biostatistics, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
    Epigenetics 4:500-11. 2009
    ....
  45. pmc Fetal alcohol spectrum disorder: an overview
    Raja A S Mukherjee
    Social and Developmental Psychiatry, St George s, University of London, UK
    J R Soc Med 99:298-302. 2006
  46. ncbi Screening, diagnosing and prevention of fetal alcohol syndrome: is this syndrome treatable?
    Sahar Ismail
    Department of Biochemistry and Molecular and Cellular Biology, Georgetown University Medical Center, Washington, D C 20057, USA
    Dev Neurosci 32:91-100. 2010
    ..teratogenic outcomes are generally known as fetal alcohol spectrum disorders, the most severe of which is fetal alcohol syndrome (FAS)...
  47. ncbi Challenges of diagnosis in fetal alcohol syndrome and fetal alcohol spectrum disorder in the adult
    Albert E Chudley
    Department of Pediatrics, University of Manitoba, Manitoba
    Am J Med Genet C Semin Med Genet 145:261-72. 2007
    Adults with fetal alcohol syndrome (FAS) and the subsets of individuals with attenuated phenotype subsumed under the umbrella term of fetal alcohol spectrum disorder (FASD) provide clinicians with a challenge...
  48. ncbi Prevention of fetal demise and growth restriction in a mouse model of fetal alcohol syndrome
    C Y Spong
    Section on Developmental and Molecular Pharmacology, Laboratory of Developmental Neurobiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Pharmacol Exp Ther 297:774-9. 2001
    ..regulated by vasoactive intestinal peptide, are shown now to provide protective intervention in a model of fetal alcohol syndrome. Fetal demise and growth restrictions were produced after intraperitoneal injection of ethanol to pregnant ..
  49. ncbi Maternal risk factors for fetal alcohol syndrome and partial fetal alcohol syndrome in South Africa: a third study
    Philip A May
    University of New Mexico, Center on Alcoholism, Substance Abuse and Addictions, Albuquerque, NM 87106, USA
    Alcohol Clin Exp Res 32:738-53. 2008
    ..exploration of risk factors for the two most severe forms of fetal alcohol spectrum disorders (FASD), fetal alcohol syndrome (FAS) and Partial FAS (PFAS), in a South African community with the highest reported prevalence of FAS in ..
  50. ncbi Midline corpus callosum is a neuroanatomical focus of fetal alcohol damage
    Fred L Bookstein
    Institute of Gerontology, University of Michigan, 300 North Ingalls Building, Ann Arbor, MI 48109 2007, USA
    Anat Rec 269:162-74. 2002
    ..in magnetic resonance (MR) brain images from 60 adolescents and adults who were normal, 60 diagnosed with fetal alcohol syndrome, and 60 diagnosed with fetal alcohol effects...
  51. pmc Neurocognitive profile in children with fetal alcohol spectrum disorders
    Piyadasa W Kodituwakku
    Center for Development and Disability, University of New Mexico School of Medicine, Albuquerque, New Mexico 87107, USA
    Dev Disabil Res Rev 15:218-24. 2009
    ..We recommend the study of developmental trajectories of both elementary and higher-order functions in future research on FASD to elucidate the development of this cognitive profile...
  52. ncbi The burden of prenatal exposure to alcohol: revised measurement of cost
    Brenda Stade
    Department of Paediatrics, St Michael s Hospital, Toronto, Canada
    Can J Clin Pharmacol 16:e91-102. 2009
    ..Only one study has examined the cost of FASD in Canada. In that study we did not include prospective data for infants under the age of one year, costs for adults beyond 21 years or costs for individuals living in institutions...
  53. pmc Magnetic resonance imaging outcomes from a comprehensive magnetic resonance study of children with fetal alcohol spectrum disorders
    Susan J Astley
    Department of Epidemiology, University of Washington, Seattle, Washington 98195 7920, USA
    Alcohol Clin Exp Res 33:1671-89. 2009
    ..Magnetic resonance (MR) technology offers noninvasive methods for in vivo assessment of neuroabnormalities...
  54. ncbi Prevalence of fatty acid ethyl esters in meconium specimens
    Christine Moore
    US Drug Testing Laboratories, 1700 S Mount Prospect Rd, Des Plaines, IL 60018, USA
    Clin Chem 49:133-6. 2003
    b>Fetal alcohol syndrome (FAS), alcohol-related birth defects (ARBDs), and alcohol-related neurodevelopment disorders (ARNDs) in neonates are often the result of maternal alcohol consumption during pregnancy...
  55. ncbi Accuracy of the diagnosis of physical features of fetal alcohol syndrome by pediatricians after specialized training
    Kenneth Lyons Jones
    Department of Pediatrics, Division of Dysmorphology and Teratology, University of California San Diego, La Jolla, California, USA
    Pediatrics 118:e1734-8. 2006
    Accurate and early diagnosis of the fetal alcohol syndrome is important for secondary prevention, intervention, and treatment, yet many pediatricians lack expertise in recognition of the characteristic features of this disorder...
  56. pmc Preventing alcohol-exposed pregnancies: a randomized controlled trial
    R Louise Floyd
    National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia 30329, USA
    Am J Prev Med 32:1-10. 2007
    ..Prenatal alcohol exposure is a leading preventable cause of birth defects and developmental disabilities in the United States...
  57. ncbi Deep serotonergic and dopaminergic structures in fetal alcoholic syndrome: a study with nor-beta-CIT-single-photon emission computed tomography and magnetic resonance imaging volumetry
    Raili S Riikonen
    Department of Child Neurology, Kuopio University Hospital, Kuopio, Finland
    Biol Psychiatry 57:1565-72. 2005
    ..In prenatally alcohol exposed children, the relationship between brain structure and function is highlighted to be important to study...
  58. ncbi Corpus callosum shape and neuropsychological deficits in adult males with heavy fetal alcohol exposure
    Fred L Bookstein
    Institute of Gerontology, University of Michigan, Ann Arbor, Michigan 48109, USA
    Neuroimage 15:233-51. 2002
    Persons with brain damage consequent to prenatal alcohol exposure have typically been diagnosed with either fetal alcohol syndrome (FAS) or fetal alcohol effects (FAE), depending on facial features...
  59. ncbi Antioxidants and fetal protection against ethanol teratogenicity. I. Review of the experimental data and implications to humans
    Raanan Cohen-Kerem
    Department of Pediatrics, University of Toronto, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada M5G 1X8
    Neurotoxicol Teratol 25:1-9. 2003
    ..Our objective is to review the data of antioxidant effects in experimental models of fetal alcohol syndrome. Prior to the description of the available experimental data, we will briefly review the mechanisms ..
  60. ncbi Genesis of alcohol-induced craniofacial dysmorphism
    Kathleen K Sulik
    Department of Cell and Developmental Biology and Bowles Center for Alcohol Studies, The University of North Carolina, CB 7090, Chapel Hill, North Carolina 27599, USA
    Exp Biol Med (Maywood) 230:366-75. 2005
    The initial diagnosis of fetal alcohol syndrome (FAS) in the United States was made because of the facial features common to the first cohort of patients...
  61. ncbi Ethanol exposure during embryogenesis decreases the radial glial progenitorpool and affects the generation of neurons and astrocytes
    Gemma Rubert
    Department of Cellular Pathology, Centro de Investigacion Principe Felipe, Valencia, Spain
    J Neurosci Res 84:483-96. 2006
    ..demonstrate that ethanol reduces the telencephalic RG progenitor pool and its transformation into neurons and astrocytes, which may contribute to an explanation of the defects in brain function often observed in fetal alcohol syndrome.
  62. pmc Alcohol use by pregnant women: partners, knowledge, and other predictors
    Grace Chang
    Department of Psychiatry, Brigham and Women s Hospital, 75 Francis Street, Boston, Massachusetts 02115, USA
    J Stud Alcohol 67:245-51. 2006
    ....
  63. ncbi Ethanol inhibits insulin expression and actions in the developing brain
    S M de la Monte
    Department of Pathology and Medicine, Pierre Galletti Research Building, Rhode Island Hospital, Providence, USA
    Cell Mol Life Sci 62:1131-45. 2005
    ..The present work explores the mechanisms of impaired insulin signaling in a rat model of fetal alcohol syndrome. Real-time quantitative RT-PCR demonstrated reduced expression of the insulin gene in cerebella of ethanol-..
  64. ncbi Mapping callosal morphology and cognitive correlates: effects of heavy prenatal alcohol exposure
    E R Sowell
    Laboratory of Neuroimaging, Department of Neurology, University of California, Los Angeles 90095 1769, USA
    Neurology 57:235-44. 2001
    Abnormalities of the corpus callosum (CC) have been documented in fetal alcohol syndrome (FAS), ranging from subtle decrements in its size to partial and even complete agenesis...
  65. ncbi The neurodevelopmental consequences of prenatal alcohol exposure
    Elizabeth Welch-Carre
    Newborn Center, The Children s Hospital Denver, Denver, CO 80020, USA
    Adv Neonatal Care 5:217-29. 2005
    ..Diagnoses associated with prenatal alcohol exposure include fetal alcohol syndrome (FAS), partial fetal alcohol syndrome, fetal alcohol effects, alcohol-related neurodevelopmental disorder, ..
  66. pmc Mapping brain maturation
    Arthur W Toga
    Laboratory of Neuro Imaging, Department of Neurology, UCLA School of Medicine, 635 Charles E Young Drive South, Suite 225, Los Angeles, CA 90095 7332, USA
    Trends Neurosci 29:148-59. 2006
    ..in healthy children, and contrast them with abnormal developmental changes in early-onset schizophrenia, fetal alcohol syndrome, attention-deficit-hyperactivity disorder (ADHD) and Williams syndrome...
  67. ncbi Hippocampal cell loss and neurogenesis after fetal alcohol exposure: insights from different rodent models
    Joana Gil-Mohapel
    Division of Medical Sciences and Department of Biology, University of Victoria, Victoria, B C, Canada
    Brain Res Rev 64:283-303. 2010
    ..We will also present an up-to-date summary on the effects of prenatal/neonatal ethanol exposure on adult hippocampal neurogenesis and cell loss, highlighting some of the possible molecular mechanisms that might be involved...
  68. ncbi Fetal alcohol syndrome: diagnosis, epidemiology, and developmental outcomes
    C M O'Leary
    Child, Community and Primary Health Care Directorate, Department of Health, Perth, Western Australia, Australia
    J Paediatr Child Health 40:2-7. 2004
    In Australia the issue of fetal alcohol syndrome (FAS) has not been the subject of policy development or of extensive research...
  69. ncbi Patterns of cognitive-motor development in children with fetal alcohol syndrome from a community in South Africa
    C M Adnams
    Department of Pediatrics, University of Cape Town, Cape Town, South Africa
    Alcohol Clin Exp Res 25:557-62. 2001
    BACKGROUND: Even though fetal alcohol syndrome (FAS) has been reported in nonwestern nations, there is a paucity of information on neurodevelopment in the affected children from those nations...
  70. pmc Under-reporting of foetal alcohol spectrum disorders: an analysis of hospital episode statistics
    Michela Morleo
    Centre for Public Health, Liverpool John Moores University, Henry Cotton Campus third floor, 15 21 Webster Street, Liverpool L3 2ET, UK
    BMC Pediatr 11:14. 2011
    ..This analysis compares hospital admissions over time, between regions and with alcohol-related admissions for adult females to assess whether established patterns (such as the North experiencing elevated harms) can be identified...
  71. ncbi Ophthalmic involvement in the fetal alcohol syndrome: clinical and animal model studies
    Kerstin Strömland
    Institute of Clinical Neuroscience, Section of Paediatric Ophthalmology, Goteborg University, The Queen Silvia Children s Hospital, Sahlgrenska University Hospital East, SE 41585 Göteborg, Sweden
    Alcohol Alcohol 37:2-8. 2002
    The fetal alcohol syndrome (FAS) is caused by maternal alcohol misuse during pregnancy and is characterized by pre- and postnatal growth retardation, central nervous system anomalies and a wide spectrum of malformations, the most typical ..
  72. ncbi Application of the fetal alcohol syndrome facial photographic screening tool in a foster care population
    Susan J Astley
    School of Public Health and Community Medicine, Seattle, Washington 98195, USA
    J Pediatr 141:712-7. 2002
    We determined the prevalence of fetal alcohol syndrome (FAS) in a foster care population and evaluated the performance of the FAS Facial Photographic Screening Tool...
  73. ncbi Protective effect of folic acid against oxidative stress produced in 21-day postpartum rats by maternal-ethanol chronic consumption during pregnancy and lactation period
    M J Cano
    , Facultad de Farmacia, Universidad de Sevilla, Spain
    Free Radic Res 34:1-8. 2001
    ..The results obtained in the present work suggest that folic acid may be useful in the prevention of damage and promotion of health of the progeny of ethanol-treated rats...
  74. ncbi Fetal alcohol syndrome among grade 1 schoolchildren in Northern Cape Province: prevalence and risk factors
    Michael Urban
    Division of Human Genetics, University of Cape Town
    S Afr Med J 98:877-82. 2008
    To describe the prevalence, characteristics and risk factors for fetal alcohol syndrome (FAS) and partial FAS among schoolgoing children in Grade 1 in Northern Cape Province, South Africa.
  75. pmc Prenatal choline supplementation mitigates the adverse effects of prenatal alcohol exposure on development in rats
    Jennifer D Thomas
    Department of Psychology, Center for Behavioral Teratology, San Diego State University, San Diego, CA 92120, USA
    Neurotoxicol Teratol 31:303-11. 2009
    ..These data indicate early dietary supplements may reduce the severity of some fetal alcohol effects, findings with important implications for children of women who drink alcohol during pregnancy...
  76. ncbi Ethanol exposure affects gene expression in the embryonic organizer and reduces retinoic acid levels
    Ronit Yelin
    Department of Cellular Biochemistry and Human Genetics, Faculty of Medicine, Hebrew University, POB 12272, Jerusalem 91120, Israel
    Dev Biol 279:193-204. 2005
    ..b>Fetal Alcohol Syndrome (FAS), the strongest manifestation of FASD, results in short stature, microcephally and facial ..
  77. ncbi Persistent impairment of hippocampal neurogenesis in young adult rats following early postnatal alcohol exposure
    Anna Y Klintsova
    Psychology Department, University of Delaware, Newark, Delaware 19716, USA
    Alcohol Clin Exp Res 31:2073-82. 2007
    ..The goal of this study was to examine the effect of postnatal binge-like alcohol exposure on cell proliferation and neurogenesis in hippocampal dentate gyrus during adolescence and young adulthood...
  78. ncbi Fetal alcohol spectrum disorder
    Raghavendra Bheemappa Nayak
    Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore 29, India
    Indian Pediatr 45:977-83. 2008
    ..Maternal alcohol use during pregnancy leads to fetal alcohol spectrum disorder (FASD) in their children. FASD is characterized by typical facial features, growth retardation, intellectual dysfunction and behavioral problems...
  79. pmc A Drosophila model for fetal alcohol syndrome disorders: role for the insulin pathway
    Kimberly D McClure
    Department of Anatomy, University of California, San Francisco, San Francisco, CA 94143, USA
    Dis Model Mech 4:335-46. 2011
    ..Our results thus establish Drosophila as a useful model system to uncover the complex etiology of fetal alcohol syndrome.
  80. ncbi Fetal alcohol syndrome at the cellular level
    John W Olney
    Addict Biol 9:137-49; discussion 151. 2004
    ..These recent findings help clarify important aspects of the fetal alcohol syndrome, and demonstrate the usefulness of an in vivo infant rodent model for studying the neurotoxic effects of ..
  81. ncbi The challenge of fetal alcohol syndrome in the criminal legal system
    Diane K Fast
    B C s Children s Hospital, Youth Forensic Psychiatric Services, University of British Columbia, Vancouver, BC, Canada
    Addict Biol 9:161-6; discussion 167-8. 2004
    ..The person with FASD can be misunderstood in court, victimized in jails, and mismanaged in the transition back to the community, unless those working with the individual are aware of FASD and its implications...
  82. ncbi Atypical functional lateralization in children with fetal alcohol syndrome
    Erik Domellöf
    Department of Psychology Umeå University SE 901 87 Umeå, Sweden
    Dev Psychobiol 51:696-705. 2009
    ..preferences of hand, foot, eye, and ear were administered to a sample of 23 children diagnosed with fetal alcohol syndrome (FAS) compared with typically developing (TD) children...
  83. pmc Prevalence of children with severe fetal alcohol spectrum disorders in communities near Rome, Italy: new estimated rates are higher than previous estimates
    Philip A May
    Center on Alcoholism, Substance Abuse, and Addictions CASAA, The University of New Mexico, 2650 Yale SE, Albuquerque, NM 87106, USA
    Int J Environ Res Public Health 8:2331-51. 2011
    To determine the population-based epidemiology of fetal alcohol syndrome (FAS) and other fetal alcohol spectrum disorders (FASD) in towns representative of the general population of central Italy.
  84. ncbi Determination of eight fatty acid ethyl esters in meconium samples by headspace solid-phase microextraction and gas chromatography-mass spectrometry
    Marli Roehsig
    College of Pharmaceutical Sciences University of São Paulo, Sao Paulo, SP, Brazil
    J Sep Sci 33:2115-22. 2010
    ..Interestingly, FAEEs could also be detected in some non-exposed newborns, although the concentrations were much lower than those measured in exposed cases...
  85. ncbi Vasoactive intestinal peptide mRNA and immunoreactivity are decreased in fetal alcohol syndrome model
    Catherine Y Spong
    Section on Developmental and Molecular Pharmacology, Laboratory of Developmental Neurobiology, NICHD, NIH, Building 49, Room 5A 38, MSC 4480, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Regul Pept 108:143-7. 2002
    ..were able to prevent the alcohol-induced fetal death, growth restriction and microcephaly associated with fetal alcohol syndrome. Here we evaluated the role of VIP in this mouse model of fetal alcohol syndrome, to determine if fetal or ..
  86. pmc Epidemiology of fetal alcohol syndrome in American Indians, Alaskan Natives, and Canadian Aboriginal peoples: a review of the literature
    L Burd
    Department of Pediatrics, University of North Dakota, School of Medicine, Grand Forks
    Public Health Rep 109:688-93. 1994
    A critical review of available reports on the epidemiology of fetal alcohol syndrome among American Indians, Alaskan Natives, and Aboriginal peoples of Canada was completed...
  87. ncbi Vitamin A, folate, and choline as a possible preventive intervention to fetal alcohol syndrome
    Mark S Ballard
    Department of Internal Medicine, University of Calgary Foothills Hospital, 1403 29 Street NW, Calgary, AB, Canada
    Med Hypotheses 78:489-93. 2012
    It is recognized that alcohol consumption during pregnancy is associated with fetal alcohol syndrome (FAS)...
  88. pmc Toward a neurobehavioral profile of fetal alcohol spectrum disorders
    Sarah N Mattson
    Center for Behavioral Teratology, San Diego State University, San Diego, California, USA
    Alcohol Clin Exp Res 34:1640-50. 2010
    ..In the current study, we define a preliminary profile using neuropsychological data from a multisite study...
  89. ncbi Goal-directed arm movements in children with fetal alcohol syndrome: a kinematic approach
    E Domellöf
    Department of Psychology, Umea University, Umea, Sweden
    Eur J Neurol 18:312-20. 2011
    Although many studies have documented deficits in general motor functioning in children with fetal alcohol syndrome (FAS), few have employed detailed measurements to explore the specific nature of such disabilities...
  90. ncbi Can prenatal screening for fetal alcohol spectrum disorder be justified? A commentary
    G J Mizejewski
    Division of Translational Medicine, Wadsworth Center, New York State Department of Health, Empire State Plaza, Albany, NY 12201, USA
    Gynecol Obstet Invest 69:128-30. 2010
    ....
  91. ncbi Advantages of mixed effects models over traditional ANOVA models in developmental studies: a worked example in a mouse model of fetal alcohol syndrome
    Patricia E Wainwright
    Department of Health Studies and Gerontology, University of Waterloo, 200 University Avenue W, Waterloo, Ontario N2L 3G1, Canada
    Dev Psychobiol 49:664-74. 2007
    ..In addition, the longitudinal modeling approach using linear MEM allowed us to model for flexible weight gain over time, as well as to provide precise estimates of these effects, which would be difficult in repeated measures ANOVA...
  92. ncbi Neurologic and ophthalmic manifestations of fetal alcohol syndrome
    Beau B Bruce
    Departments of Ophthalmology and Neurology, Emory University School of Medicine, Atlanta, GA, USA
    Rev Neurol Dis 6:13-20. 2009
    b>Fetal alcohol syndrome (FAS) is a leading cause of preventable birth defects and developmental disability with numerous neurologic and ophthalmic manifestations...
  93. ncbi Identifying maternal self-reported alcohol use associated with fetal alcohol spectrum disorders
    H M Barr
    Department of Psychiatry and Behavioral Sciences, Fetal Alcohol and Drug Unit, University of Washington School of Medicine, Seattle 98195, USA
    Alcohol Clin Exp Res 25:283-7. 2001
    BACKGROUND: The incidence of Fetal Alcohol Syndrome (FAS) has been estimated at 1 to 3 per 1,000 live births. Fetal Alcohol Spectrum Disorders (FASD) (which include FAS) are estimated to occur in about 1 in 100 births...
  94. ncbi A Guinea pig model for the identification of in utero alcohol exposure using fatty acid ethyl esters in neonatal hair
    Daniela L Caprara
    Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, Toronto, and Department of Pharmacology and Toxicology, Faculty of Health Sciences, Queen s University, Kingston, Ontario, Canada
    Pediatr Res 58:1158-63. 2005
    ..Results of this study suggest that FAEE in neonatal hair may be useful biomarkers in identifying in utero alcohol exposure and may facilitate the early diagnosis and treatment of FASD...
  95. pmc Fetal alcohol exposure leads to abnormal olfactory bulb development and impaired odor discrimination in adult mice
    Katherine G Akers
    Neurosciences and Mental Health, Hospital for Sick Children, and Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada
    Mol Brain 4:29. 2011
    ..Here, we used a mouse model of fetal alcohol exposure to investigate relationships between brain abnormalities and specific behavioral alterations during adulthood...
  96. pmc Nicotinamide protects against ethanol-induced apoptotic neurodegeneration in the developing mouse brain
    Alessandro Ieraci
    Department of Psychiatry, Weill Medical College of Cornell University, New York, New York, USA
    PLoS Med 3:e101. 2006
    Exposure to alcohol during brain development may cause a neurological syndrome called fetal alcohol syndrome (FAS)...
  97. ncbi Normal distribution of palpebral fissure lengths in Canadian school age children
    Sterling K Clarren
    Canada Northwest FASD Research Network, Vancouver, Canada
    Can J Clin Pharmacol 17:e67-78. 2010
    b>Fetal alcohol syndrome (FAS) includes the facial dysmorphic feature of short palpebral fissures (PFs) and short PFs are a key physical marker for identifying children with FAS and some other rarer conditions...
  98. ncbi Fetal alcohol syndrome: cardiac birth defects in mice and prevention with folate
    Maria Serrano
    Pediatric Residency Program, College of Medicine, University of Florida, Jacksonville, FL, USA
    Am J Obstet Gynecol 203:75.e7-75.e15. 2010
    ..ethanol) consumption during pregnancy is linked to congenital heart defects that are associated with fetal alcohol syndrome. Recent reports have associated ethanol exposure with the Wnt/beta-catenin pathway...
  99. ncbi In vitro neurogenesis from neural progenitor cells isolated from the hippocampus region of the brain of adult rats exposed to ethanol during early development through their alcohol-drinking mothers
    Ashok K Singh
    Department of Veterinary Population Medicine, College of Veterinary Medicine, University of Minnesota, Twin Cities Campus, St Paul, MN 55108, USA
    Alcohol Alcohol 44:185-98. 2009
    ..This study was aimed to determine whether ethanol exposure during early development altered neurogenesis in the brain of adult rats...
  100. ncbi Postnatal growth restriction and gene expression changes in a mouse model of fetal alcohol syndrome
    Nina Kaminen-Ahola
    Epigenetics Laboratory, Queensland Institute of Medical Research, 300 Herston Rd, Herston, Queensland 4006, Australia
    Birth Defects Res A Clin Mol Teratol 88:818-26. 2010
    ..craniofacial dysmorphology, and central nervous system defects are the main diagnostic features of fetal alcohol syndrome. Studies in humans and mice have reported that the growth restriction can be prenatal or postnatal, but ..
  101. ncbi Novel peptides prevent alcohol-induced spatial learning deficits and proinflammatory cytokine release in a mouse model of fetal alcohol syndrome
    Joy Vink
    Unit on Perinatal and Developmental Neurobiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA
    Am J Obstet Gynecol 193:825-9. 2005
    ..SALLRSIPA were shown to prevent alcohol-induced fetal death and growth abnormalities in a mouse model of fetal alcohol syndrome. This study evaluated whether these peptides could prevent long-term alcohol-induced learning ..

Research Grants74

  1. Mechanisms of ethanol-induced neurodevelopmental effects
    Marina Guizzetti; Fiscal Year: 2011
    ..to severe brain damage, including microcephaly and mental retardation, both of which are hallmarks of the fetal alcohol syndrome. The effects of ethanol on cholesterol homeostasis in the developing brain have not been investigated...
  2. Chronic ethanol, B cell competence and lymphoid integrity
    Thomas J Waldschmidt; Fiscal Year: 2010
    ..In addition to immune deficiency caused by extended ethanol intake, children with fetal alcohol syndrome (FAS) also display immunologic deficits and higher infection rates...
  3. GSK3beta, a mediator of ethanol neurotoxicity
    Xianglin Shi; Fiscal Year: 2013
    ..consumption during pregnancy may cause Fetal Alcohol Spectrum Disorders (FASD), among which, fetal alcohol syndrome (FAS) is the most severe form...
  4. Epigenetic Effects of Prenatal Ethanol Exposure
    Thomas P Yang; Fiscal Year: 2010
    b>Fetal alcohol syndrome (FAS) is a significant cause of mental retardation and birth defects worldwide...
  5. Role of Beta Spectrin and Smad in Alcohol Induced Liver and GI Cell Proliferation
    Lopa Mishra; Fiscal Year: 2013
    ..Importantly, the [unreadable]2SP mouse mutants phenocopy a fetal alcohol syndrome in a large number of cases and the [unreadable]2SP mutants are highly susceptible to alcohol injury...
  6. Genetic and Molecular Mechanisms of Ethanol-Induced Developmental Defects
    RACHAEL LOUISE FRENCH; Fiscal Year: 2013
    ..In humans, these symptoms are collectively described as fetal alcohol syndrome (FAS)...
  7. Integrated imaging of the form and function of the beating embryonic heart
    ANDREW MARTIN ROLLINS; Fiscal Year: 2013
    ..g. alcohol). We have chosen to focus on the connections between the etiology of CHDs associated with Fetal Alcohol Syndrome (FAS), NCCs, and their ability to influence cardiac function from an early stage...
  8. Is Maternal Iron Status a Risk Factor in Fetal Alcohol Syndrome?
    Susan M Smith; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: Fetal alcohol syndrome is the leading known cause of mental retardation...
  9. Effect of alcohol exposure on human Treg induction &CD36HI monocyte biology
    KATHLEEN ELIZABETH JAEGER; Fiscal Year: 2013
    ..provided by applicant): In addition to the neuropsychological and behavioral disorders inherent in fetal alcohol syndrome (FAS), significant impairments in immune function have been identified in these patients...
  10. Ethanol Dependence and Kappa Receptor Antagonists
    MARC REZA AZAR; Fiscal Year: 2011
    ..e., alcohol toxicity), and fetal alcohol syndrome. Alcoholism is a chronic relapsing disorder characterized by multiple stages and multiple sources of ..
  11. Cellular Biomechanics of Heat-Shock Induced Defects in Drosophila Embryogenesis
    M Shane Hutson; Fiscal Year: 2013
    ..to alcohol can lead to a characteristic spectrum of defects, in the most severe cases characterized as fetal alcohol syndrome. The project focuses on similar effects in the model system of Drosophila melanogaster in which the ..
  12. NFkB Targets and Neural Crest Development
    MICHAEL WILLIAM KLYMKOWSKY; Fiscal Year: 2010
    ..the neural crest underlie the neurological, craniofacial, and dental malformations associated with Fetal Alcohol Syndrome (FAS) and the less severe, but still significant alcohol-related neurodevelopmental disorder (ARND) and ..
  13. Ethanol and Bcl-2 Gene Interactions in the Developing CNS
    Marieta B Heaton; Fiscal Year: 2012
    ..Such exposure can lead to the fetal alcohol syndrome (FAS) or alcohol-related birth defects (ARBD)...
  14. Adaptive tissue permeability to alcohol in C. elegans
    Jonathan T Pierce-Shimomura; Fiscal Year: 2011
    ..Damage to the nervous tissue incurred during development can lead to fetal alcohol syndrome which is the main preventable form of mental retardation...
  15. EXPERIMENTAL FETAL ALCOHOL SYNDROME
    Sandra M Mooney; Fiscal Year: 2013
    ....
  16. Short-Chain Dehydrogenases in Retinol/Sterol Metabolism
    Natalia Y Kedishvili; Fiscal Year: 2013
    ..The results of these studies will be important for understanding the pathophysiology of disorders associated with disruptions of retinoid homeostasis, such as fetal alcohol syndrome, alcoholic liver disease, carcinogenesis, and diabetes.
  17. Molecular mechanism of ADNF and ADNP peptides in prevention of mitochondrial dysf
    Youssef Sari; Fiscal Year: 2010
    ..In a model of fetal alcohol syndrome (FAS), these peptides have been shown to prevent alcohol-induced decreases in reduced mitochondrial ..
  18. Whole brain multimodal microscopy of an apoptosis reporter mouse
    PETER JEFF NICHOLLS; Fiscal Year: 2013
    ..It is a key component of disparate brain disorders including fetal alcohol syndrome, ischemic stroke, and Parkinson's disease;and it may play a role in behavioral disorders such as ..
  19. Ethanol effects on retinoic acid function in embryo hippocampus
    Joseph L Napoli; Fiscal Year: 2013
    ..memory, super physiological concentrations of atRA could contribute to ethanol toxicity, including fetal alcohol syndrome. We will test the hypothesis that ethanol-induced increases in embryo hippocampus atRA contributes to ..
  20. Genetic and behavioral analysis of developmental ethanol exposure in Drosophila
    KIMBERLY DEVON MCCLURE; Fiscal Year: 2010
    The goal of the proposed studies is to develop Drosophila melanogaster as an animal model to investigate fetal alcohol syndrome. Previous studies indicate that genetic factors can modulate the degree of alcohol teratogenic risk, yet the ..
  21. Paternal preconception alcohol on epigenetics and offspring drinking
    Andrey Finegersh; Fiscal Year: 2013
    ..These findings will be important for studying transgenerational inheritance of behaviors in the following generation. Our findings may also reveal new epigenetic targets for the treatment of alcoholism and fetal alcohol syndrome (FAS).
  22. Fetal Alcohol Effects on Circadian clocks and POMC
    DIPAK KUMAR SARKAR; Fiscal Year: 2010
    Exposure of a fetus to ethanol can lead to the development of fetal alcohol syndrome, which is characterized by various morphological and behavioral deficits in fetal alcohol-exposed (FAE) offspring...
  23. Translational Studies of FASD Using a Sheep Model-U01
    Shannon E Washburn; Fiscal Year: 2011
    ..These studies evaluate phenotypic measures used in the diagnosis of fetal alcohol syndrome-growth, facial dysmorphology, and brain and behavioral development-using methods derived explicitly from ..
  24. Exploratory Trial of Choline Supplementation for Fetal Alcohol Syndrome
    Sandra W Jacobson; Fiscal Year: 2013
    ..of child-bearing age, very heavy alcohol consumption during pregnancy, and one of the highest rates of fetal alcohol syndrome (FAS) in the world...
  25. NO-mediated neuroprotection against alcohol toxicity
    Nicholas J Pantazis; Fiscal Year: 2010
    b>Fetal alcohol syndrome (FAS) is an important cause of mental retardation...
  26. Causes of Variability in Craniofacial Disease
    Johann K Eberhart; Fiscal Year: 2013
    ..We have chosen to use Fetal Alcohol Syndrome (FAS) as a model of gene/environment interactions because FAS has variable craniofacial defects, has a ..
  27. Mechanisms and Nutritional Intervention for Fetal Alcohol Spectrum Disorders
    Shannon E Washburn; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: The failure of education to significantly reduce the incidence of Fetal Alcohol Syndrome has made it important to obtain understanding of the mechanisms by which prenatal alcohol exposure causes ..
  28. Development of Visual Pathways
    Hwai Jong Cheng; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: Neurodevelopmental disorders, including autism, schizophrenia, fetal alcohol syndrome, seizure disorders, attention deficit / hyperactivity disorder, etc...
  29. TRAINING GRANT ON GENETIC ASPECTS OF ALCOHOLISM
    Cristine L Czachowski; Fiscal Year: 2013
    ..and genetics underlying co-abuse of alcohol and nicotine;and neurodevelopmental abnormalities of fetal alcohol syndrome in rodent models...
  30. Preventing FAS/ARND in Russian Children
    Tatiana N Balachova; Fiscal Year: 2012
    This proposal extends a line of international collaborative research for preventing Fetal Alcohol Syndrome (FAS) and Alcohol Related Neurodevelopmental Disorder (ARND) in Russia...
  31. Mouse Model Neuro-Facial Dysmorphology: Tanslational and Treatment Studies
    Feng C Zhou; Fiscal Year: 2011
    b>Fetal alcohol syndrome (FAS) occurs in children born to women who drink alcohol heavily during pregnancy and is one of the leading non-hereditary causes of mental retardation in the Western World...
  32. MAGNETIC RESONANCE AND DIFFUSION TENSOR IMAGING OF A MOUSE FASD MODEL U01
    Kathleen K Sulik; Fiscal Year: 2011
    ..critical exposure times that yield facial and CNS abnormalities that are consistent with full-blown Fetal Alcohol Syndrome, as well as other components of FASD...
  33. BIOMEDICAL ALCOHOL RESEARCH TRAINING PROGRAM
    GREGORY JOHN BAGBY; Fiscal Year: 2013
    ..on a major health concern, the biomedical consequences of alcohol use disorders such as liver disease, fetal alcohol syndrome, pneumonia and HIV disease. In the U.S...
  34. Brain Imaging of Newborns with Fetal Alcohol Syndrome
    ANDRE JAN WILLEM VAN DER KOUWE; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Since 1998, we have been collaborating on research on fetal alcohol syndrome (FAS) in Cape Town, South Africa, where the incidence of FAS is among the highest in the world...
  35. Alcohol consumption before, during, and after unwanted pregnancy
    Sarah C M Roberts; Fiscal Year: 2013
    ..consumption during pregnancy can cause a range of fetal alcohol effects including, but not limited to, Fetal Alcohol Syndrome, and alcohol consumption after pregnancy can impair the ability to breastfeed safely...
  36. Neuroanatomical/Functional Correlates in an FASD Model
    SCOTT PARNELL; Fiscal Year: 2013
    ..While both structural and functional abnormalities of the brain have been described in individuals with Fetal Alcohol Syndrome (FAS)/Fetal Alcohol Spectrum Disorders (FASD), gaps remain in our understanding of the full range of these ..
  37. Early Indices of Atypical Neurodevelopment with Fetal Alcohol Exposure
    JULIA MARIE STEPHEN; Fiscal Year: 2013
    ..by applicant): It is well-established that children with the facial dysmorphias characteristic of fetal alcohol syndrome (FAS) have cognitive and behavioral deficits...
  38. Alcohol and Contraception Risk Reduction Internet Intervention to Prevent FASD
    Karen S Ingersoll; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Fetal Alcohol Spectrum Disorders (FASDs), including Fetal Alcohol Syndrome, lead to enormous societal and financial costs...
  39. Effects of Alcohol on Microglia and Innate Immunity
    Paul D Drew; Fiscal Year: 2010
    b>Fetal alcohol syndrome and related disorders occur in approximately 1% of live births in the United States and represent the most common cause of mental retardation...
  40. FETAL ALCOHOL SPECTRUM DISEASE IN LOW INCOME COUNTRIES
    Na Na; Fiscal Year: 2012
    ..The most serious adverse consequence of prenatal alcohol exposure is fetal alcohol syndrome (FAS), a devastating developmental disorder characterized by craniofacial abnormalities, growth ..
  41. Effects of Adenylyl Cyclases 1 and 8 on Neuronal Sensitivity to Ethanol
    Alana C Conti; Fiscal Year: 2012
    ..objectives of this proposal are to define the mechanisms underlying the neurotoxic effects of ethanol in Fetal Alcohol Syndrome (FAS)...
  42. The Effects of Alcohol Policies on Fetal Health and Children's Development
    MARIANNE ELIZABETH PAGE; Fiscal Year: 2010
    ..a benefit of more restrictive alcohol policies may be that they reduce the incidence of such outcomes as fetal alcohol syndrome and improve infants'overall well-being...
  43. Prenatal Alcohol in Sudden Infant Death Syndrome and Stillbirth (PASS) Network
    Amy J Elliott; Fiscal Year: 2013
    ..and systemic functions in infants under the rubric of fetal alcohol spectrum disorders (FASD), with fetal alcohol syndrome at the most severe end of the spectrum...
  44. Mechanisms of Forebrain Development
    Elizabeth M Powell; Fiscal Year: 2010
    ..The behavioral phenotype is similar to observations from children afflicted fetal alcohol syndrome, including anxiety, social dysfunction and seizure disorders...
  45. Optimal Treatment-recovery Frameworks for Women with Substance Abuse Problems
    DEBORAH FINFGELD CONNETT; Fiscal Year: 2010
    ..Among women of childbearing age, fetal alcohol syndrome is a concern, whereas, older women are particularly susceptible to medication interactions and ..
  46. An ERP Study of Infant Numerosity in Fetal Alcohol Syndrome
    Sandra W Jacobson; Fiscal Year: 2012
    ..high incidence of alcohol abuse and dependence in women of child-bearing age and the incidence of fetal alcohol syndrome is among the highest in the world...
  47. OVINE MODEL SYSTEM FOR ALCOHOL RELATED BIRTH DEFECTS
    Shannon E Washburn; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: The failure of education to significantly reduce the incidence of Fetal Alcohol Syndrome has made it important to obtain understanding of the mechanisms by which prenatal alcohol exposure causes ..
  48. The effects of alcohol on synaptic plasticity in the visual system
    Anna K Majewska; Fiscal Year: 2013
    ..key aspects of alcohol- induced structurl synaptic plasticity in a third trimester exposure mouse model of fetal alcohol syndrome (Aim 1), and assay visual plasticity in this system (Aim 2)...
  49. Training in Neuroimmunoendocrine Effects of Alcohol
    Elizabeth J Kovacs; Fiscal Year: 2013
    ..Druse-Manteuffel, PhD, Professor of Cell and Molecular Physiology, who works on neuronal consequences of fetal alcohol syndrome. They will lead the T32's Executive Committee, consisting of a subset of the Alcohol Research Program&..
  50. A Multisite Neurobehavioral Assessment of Fetal Alcohol Spectrum Disorders
    SARAH N MATTSON WELLER; Fiscal Year: 2013
    ..Although nearly 40 years have passed since the initial clinical delineation of fetal alcohol syndrome (FAS), understanding of the full spectrum of effects of prenatal alcohol exposure (AE) is incomplete...
  51. Neural Bases of Eyeblink Conditioning in FASD
    Sandra W Jacobson; Fiscal Year: 2012
    ..mixed ancestry) community in Cape Town, South Africa, where there is an exceptionally high incidence of fetal alcohol syndrome (FAS)...
  52. Spatial Working Memory in Children with FASD: A Multimodal Imaging Approach
    MARIA ALEJANDRA INFANTE; Fiscal Year: 2013
    ..by applicant): Prenatal alcohol exposure is known to result in a variety of deleterious effects from the fetal alcohol syndrome (FAS) to less obvious birth defects and cognitive and behavioral anomalies...
  53. Research in Intellectual and Developmental Disabilities
    Michael J Guralnick; Fiscal Year: 2013
    ..Research Emphasis Areas;Autism, Craniofacial Malformations, Developmental Toxicology, Ecological Factors, Fetal Alcohol Syndrome, Fragile X Syndrome, Infectious Disease and Immunology, Joubert Syndrome, Learning Disabilities, ..
  54. POTENTIAL FETOPROTECTANTS FROM ETOH-INDUCED STRESS
    Linda La Grange; Fiscal Year: 2000
    ..It is now theorized that the pervasive and toxic effects of LPO may contribute to the expression of fetal alcohol syndrome (FAS)...
  55. ETHANOL PLACENTO TOXICITY--INSULIN AND IGF-1 SIGNALLING
    Stanley Fisher; Fiscal Year: 1999
    ..ethanol abuse during pregnancy causes impaired fetal growth and development, a characteristic of the Fetal Alcohol Syndrome. Ethanol which freely crosses the placenta, has direct effects upon the fetus, but adversely affects ..
  56. Dysmorphology Core
    Kenneth Lyons Jones; Fiscal Year: 2013
    ..by applicant): Although the brain is the developing structure most sensitive to alcohol, the diagnosis of Fetal Alcohol syndrome (FAS), which represents the most severe end of the spectrum of Fetal Alcohol Spectrum Disorders (FASD), is ..
  57. Neural Mechanisms Underlying the Ontogeny of Eyeblink Conditioning
    John H Freeman; Fiscal Year: 2013
    ..The findings of these experiments may then be used to guide studies of atypical neural development in models of developmental disorders such as autism, Down syndrome, fragile x syndrome, and fetal alcohol syndrome.
  58. Trajectory of FASD across the Lifespan: New Understandings in Intervention
    PHILIP ALAN MAY; Fiscal Year: 2013
    ..the most recent wave already finalized for the prevention community (Wellington IV) were: 94 per 1,000 for fetal alcohol syndrome (FAS), 56 per 1,000 for partial fetal alcohol syndrome (PFAS), and 30 per 1,000 for alcohol-related neuro-..
  59. ALCOHOL INTERACTION WITH L1 CELL ADHESION MOLECULE
    MICHAEL CHARNESS; Fiscal Year: 1999
    ..Mental retardation, hydrocephalus, and agenesis of the corpus callosum are observed both in fetal alcohol syndrome (FAS) and in children with mutations in the gene for the cell adhesion molecule (CAM) L1...
  60. Mechanisms and consequences of CNS aneuploidies altered by fetal ethanol exposure
    Jerold Chun; Fiscal Year: 2013
    ..by applicant): In utero exposure to alcohol can have major deleterious effects as documented for "fetal alcohol syndrome (FAS)" and more recently and broadly as "fetal alcohol spectrum disorders (FASD)...
  61. Identification of Factors Influencing Climbing Fiber Neuron Fate in the Dorsal Hi
    REBECCA LANDSBERG; Fiscal Year: 2009
    ..in ION formation have been documented in association with a number of inherited ataxic syndromes, autism, fetal alcohol syndrome, and sudden infant death syndrome (SIDS), the leading cause of infant mortality in the United States...
  62. Craniofacial defects in ethanol-exposed zebrafish
    Sara Ahlgren; Fiscal Year: 2004
    Craniofacial abnormalities are characteristic of embryonic exposure to alcohol. In typical fetal alcohol syndrome poor development of a number of facial features, all of which are derived from the cranial neural crest, is observed...
  63. RAT MODEL OF FETAL ALCOHOL SYNDROME
    ASA BLACK; Fiscal Year: 1993
    ..and abnormal central nervous system (CNS) development are among the most devastating consequences of the fetal alcohol syndrome in humans...
  64. PARENTAL DRINKING, TOXICANT INTERACTIONS, AND PREGNANCY
    David Savitz; Fiscal Year: 1993
    Since the identification of the fetal alcohol syndrome two decades ago, the adverse reproductive effects of heavy maternal drinking and maternal alcohol abuse in pregnancy have been well documented...
  65. TRIAL OF FAS PREVENTION IN AMERICAN INDIAN COMMUNITIES
    Philip May; Fiscal Year: 2001
    DESCRIPTION: American Indians have been characterized as having high rates of Fetal Alcohol Syndrome (FAS). There is, however, substantial variation in FAS rates among Indian communities and tribes...
  66. Fetal Ethanol Effects on the Peripheral Nervous System
    Mary Johnson; Fiscal Year: 2004
    ..The most recognizable child with fetal alcohol syndrome (FAS) has growth retardation, craniofacial abnormalities and central nervous system (CNS) dysfunction, but ..
  67. ETHANOL CEREBELLAR PATHOLOGY--RETINOIDS AND GLYCOLIPIDS
    M Ullman; Fiscal Year: 2001
    DESCRIPTION: (Adapted from the Investigator's Abstract) Cerebellar pathology in fetal alcohol syndrome (FAS) is a detrimental effect of ethanol exposure during development in humans and rats...
  68. MOLECULAR ANALYSIS OF ETHANOL-INDUCED OROFACIAL DEFECTS
    M Pisano; Fiscal Year: 1993
    ..The multisystem abnormalities resulting from in utero alcohol exposure, termed "fetal alcohol syndrome" (FAS), include: 1) pre- and postnatal growth retardation, 2) cranial/facial defects such as microcephaly, ..
  69. REGULATION OF ALCOHOL DEHYDROGENASE GENE EXPRESSION
    Gregg Duester; Fiscal Year: 2000
    ..For alcohol use during pregnancy, this may be a contributing factor in fetal alcohol syndrome, characterized by malformations of craniofacial tissues known to require retinoic acid for proper ..
  70. Neonatal Ethanol-Induced Memory Impairments in Rats
    Pamela Hunt; Fiscal Year: 2009
    ..Individuals diagnosed with Fetal Alcohol Syndrome (FAS) or ARND exhibit significant deficits in a variety of memory domains, including explicit, declarative,..
  71. ETHANOL AND EXCITATORY AMINO ACID FUNCTION IN BRAIN
    Raphael Rubin; Fiscal Year: 1999
    Prenatal ethanol exposure in the developing human CNS can result in severe mental retardation linked to fetal alcohol syndrome or associated attention disorders and hyperactivity...
  72. Involvement of Permeability Transition Pore in Developmental Alcohol Neurotoxicit
    MARIETA HEATON; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Animal fetal alcohol syndrome (FAS) models have demonstrated a temporal window during the brain growth spurt in which cerebellum is particularly vulnerable to the neurotoxic effects of ethanol (EtOH)...
  73. FETAL ALCOHOL SYNDROME: GENETIC STUDIES IN ZEBRAFISH
    MICHAEL CARVAN; Fiscal Year: 2002
    ..b>Fetal Alcohol Syndrome (FAS) is a constellation of congenital anomalies seen in some newborns exposed to alcohol through maternal ..
  74. Mechanism of Alcohol Induced Neurotoxicity
    Ugra Singh; Fiscal Year: 2009
    ..of alcohol increases blood ethanol concentration and induces brain developmental disorders manifested as fetal alcohol syndrome (FAS). Children born with FAS have abnormal facial features with mild to sever mental retardation...