congenital toxoplasmosis

Summary

Summary: Prenatal protozoal infection with TOXOPLASMA gondii which is associated with injury to the developing fetal nervous system. The severity of this condition is related to the stage of pregnancy during which the infection occurs; first trimester infections are associated with a greater degree of neurologic dysfunction. Clinical features include HYDROCEPHALUS; MICROCEPHALY; deafness; cerebral calcifications; SEIZURES; and psychomotor retardation. Signs of a systemic infection may also be present at birth, including fever, rash, and hepatosplenomegaly. (From Adams et al., Principles of Neurology, 6th ed, p735)

Top Publications

  1. ncbi Outcome of treatment for congenital toxoplasmosis, 1981-2004: the National Collaborative Chicago-Based, Congenital Toxoplasmosis Study
    Rima McLeod
    Department of Ophthalmology and Visual Sciences, University of Chicago, Chicago, Illinois 60637, USA
    Clin Infect Dis 42:1383-94. 2006
  2. pmc Incidence of congenital toxoplasmosis estimated by neonatal screening: relevance of diagnostic confirmation in asymptomatic newborn infants
    C G Carvalheiro
    Department of Pediatrics, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Sao Paulo, Brasil
    Epidemiol Infect 133:485-91. 2005
  3. ncbi Genotype of 86 Toxoplasma gondii isolates associated with human congenital toxoplasmosis, and correlation with clinical findings
    Daniel Ajzenberg
    Service de Parasitologie Mycologie, EA 3174, Faculte de Medecine, Limoges, France
    J Infect Dis 186:684-9. 2002
  4. ncbi Disease burden of congenital toxoplasmosis
    A H Havelaar
    National Institute for Public Health and the Environment, Netherlands Center for Infectious Disease Control, Bilthoven, The Netherlands
    Clin Infect Dis 44:1467-74. 2007
  5. ncbi Impact of health education on knowledge and prevention behavior for congenital toxoplasmosis: the experience in Poznań, Poland
    Z S Pawlowski
    University of Medical Sciences, , Poland
    Health Educ Res 16:493-502. 2001
  6. ncbi Congenital toxoplasmosis and reinfection during pregnancy: case report, strain characterization, experimental model of reinfection, and review
    Annie Elbez-Rubinstein
    Service de Neonatologie, Hopital Intercommunal de Creteil, Creteil, France
    J Infect Dis 199:280-5. 2009
  7. pmc Ocular sequelae of congenital toxoplasmosis in Brazil compared with Europe
    Ruth E Gilbert
    Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, London, United Kingdom
    PLoS Negl Trop Dis 2:e277. 2008
  8. ncbi Prevention of congenital toxoplasmosis in Slovenia by serological screening of pregnant women
    Jernej Logar
    Department of Parasitology, Institute of Microbiology and Immunology, Medical Faculty, University of Ljubljana, Slovenia
    Scand J Infect Dis 34:201-4. 2002
  9. pmc Why prevent, diagnose and treat congenital toxoplasmosis?
    Rima McLeod
    Department of Ophthalmology and Visual Sciences, Committees on Immunology, Genetics, Molecular Medicine, The College, University of Chicago, Chicago, IL 60637, USA
    Mem Inst Oswaldo Cruz 104:320-44. 2009
  10. ncbi Screening for congenital toxoplasmosis: accuracy of immunoglobulin M and immunoglobulin A tests after birth
    Ruth E Gilbert
    Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, London, UK
    J Med Screen 14:8-13. 2007

Research Grants

  1. Development of an Inhibitor of Toxoplasma gondii
    Richard D Wood; Fiscal Year: 2010
  2. Innate Immune Receptors for Toxoplasma gondii
    Ricardo Gazzinelli; Fiscal Year: 2010
  3. SURFACE PROTEINS OF TOXOPLASMA GONDII
    Gary Ward; Fiscal Year: 2002
  4. CONGENITAL TOXOPLASMOSIS & MATERNAL HIV-1 INFECTION
    Charles Mitchell; Fiscal Year: 1991
  5. TOXOPLASMOSIS--INFECTION AND IMMUNE RESPONSE
    Jack Remington; Fiscal Year: 2001
  6. IFN Inhibition of Toxoplasma gondii in Astrocytes
    SANDRA HALONEN; Fiscal Year: 2006
  7. IFN Immune Effector Mechanisms in Cerebral Toxoplasmosis
    SANDRA HALONEN; Fiscal Year: 2006
  8. ARTEMISININ ANALOGS FOR THE TREATMENT OF TOXOPLASMOSIS
    TIMOTHY ZIEBARTH; Fiscal Year: 1992
  9. Outcomes in congenital toxoplasmic retinochoroiditis
    Ruth Gilbert; Fiscal Year: 2005
  10. TREATMENT OF CONGENITAL TOXOPLASMOSIS
    Rima L McLeod; Fiscal Year: 2010

Detail Information

Publications227 found, 100 shown here

  1. ncbi Outcome of treatment for congenital toxoplasmosis, 1981-2004: the National Collaborative Chicago-Based, Congenital Toxoplasmosis Study
    Rima McLeod
    Department of Ophthalmology and Visual Sciences, University of Chicago, Chicago, Illinois 60637, USA
    Clin Infect Dis 42:1383-94. 2006
    Without treatment, congenital toxoplasmosis has recurrent, recrudescent, adverse outcomes...
  2. pmc Incidence of congenital toxoplasmosis estimated by neonatal screening: relevance of diagnostic confirmation in asymptomatic newborn infants
    C G Carvalheiro
    Department of Pediatrics, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Sao Paulo, Brasil
    Epidemiol Infect 133:485-91. 2005
    b>Congenital toxoplasmosis is rarely identified by routine clinical examination. The aim of this study was to estimate the incidence of the disease in the region of Ribeirão Preto, south-eastern Brazil...
  3. ncbi Genotype of 86 Toxoplasma gondii isolates associated with human congenital toxoplasmosis, and correlation with clinical findings
    Daniel Ajzenberg
    Service de Parasitologie Mycologie, EA 3174, Faculte de Medecine, Limoges, France
    J Infect Dis 186:684-9. 2002
    To study the influence of Toxoplasma gondii genotypes on the severity of human congenital toxoplasmosis (asymptomatic, benign, or severe infection or newborn or fetal death), 8 microsatellite markers were used to analyze 86 T...
  4. ncbi Disease burden of congenital toxoplasmosis
    A H Havelaar
    National Institute for Public Health and the Environment, Netherlands Center for Infectious Disease Control, Bilthoven, The Netherlands
    Clin Infect Dis 44:1467-74. 2007
    ..The estimated disease burden of congenital toxoplasmosis in The Netherlands is 620 (range, 220-1900) disability-adjusted life years per year, which is similar to ..
  5. ncbi Impact of health education on knowledge and prevention behavior for congenital toxoplasmosis: the experience in Poznań, Poland
    Z S Pawlowski
    University of Medical Sciences, , Poland
    Health Educ Res 16:493-502. 2001
    ..Toxoplasma gondii is transmitted/acquired was better than the knowledge of individual risk factors for congenital toxoplasmosis. Correct hygienic behaviors in pregnancy were often practised by women who lacked good knowledge of ..
  6. ncbi Congenital toxoplasmosis and reinfection during pregnancy: case report, strain characterization, experimental model of reinfection, and review
    Annie Elbez-Rubinstein
    Service de Neonatologie, Hopital Intercommunal de Creteil, Creteil, France
    J Infect Dis 199:280-5. 2009
    We present a case of disseminated congenital toxoplasmosis in a newborn born to a mother who had been immunized against toxoplasmosis before conception...
  7. pmc Ocular sequelae of congenital toxoplasmosis in Brazil compared with Europe
    Ruth E Gilbert
    Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, London, United Kingdom
    PLoS Negl Trop Dis 2:e277. 2008
    ..Evidence is accumulating that more virulent genotypes of Toxoplasma gondii predominate in South America...
  8. ncbi Prevention of congenital toxoplasmosis in Slovenia by serological screening of pregnant women
    Jernej Logar
    Department of Parasitology, Institute of Microbiology and Immunology, Medical Faculty, University of Ljubljana, Slovenia
    Scand J Infect Dis 34:201-4. 2002
    A programme for the prevention of congenital toxoplasmosis in Slovenia involving the screening of pregnant women for Toxoplasma infection is presented...
  9. pmc Why prevent, diagnose and treat congenital toxoplasmosis?
    Rima McLeod
    Department of Ophthalmology and Visual Sciences, Committees on Immunology, Genetics, Molecular Medicine, The College, University of Chicago, Chicago, IL 60637, USA
    Mem Inst Oswaldo Cruz 104:320-44. 2009
    ..Outcomes of untreated congenital toxoplasmosis include adverse ocular and neurologic sequelae described in different countries and decades...
  10. ncbi Screening for congenital toxoplasmosis: accuracy of immunoglobulin M and immunoglobulin A tests after birth
    Ruth E Gilbert
    Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, London, UK
    J Med Screen 14:8-13. 2007
    ..To determine the accuracy of postnatal screening for toxoplasma-specific immunoglobulin (Ig) M and IgA...
  11. ncbi Evaluation of protective effect of DNA vaccination with genes encoding antigens GRA4 and SAG1 associated with GM-CSF plasmid, against acute, chronical and congenital toxoplasmosis in mice
    Marie Noëlle Mévélec
    Universite Francois Rabelais de Tours, INRA, UMR 483 Université INRA d Immunologie Parasitaire et Vaccinologie, IFR Agents transmissibles et Infectiologie, UFR des Sciences Pharmaceutiques, 31 Avenue Monge, 37200 Tours, France
    Vaccine 23:4489-99. 2005
    ..gondii SAG1 and GRA4 antigens. Our data demonstrated that protection was improved by associating antigens (SAG1 and GRA4) and cytokine (GM-CSF) for further development of a multiantigenic vaccine against toxoplasmosis...
  12. ncbi Risk factors for Toxoplasma gondii infection in mothers of infants with congenital toxoplasmosis: Implications for prenatal management and screening
    Kenneth M Boyer
    Rush University Medical Center, Chicago, Ill, USA
    Am J Obstet Gynecol 192:564-71. 2005
    ..whether demographic characteristics, history of exposure to recognized transmission vehicles, or illness that was compatible with acute toxoplasmosis during gestation identified most mothers of infants with congenital toxoplasmosis.
  13. ncbi Prenatal diagnosis of congenital toxoplasmosis by duplex real-time PCR using fluorescence resonance energy transfer hybridization probes
    J M Costa
    Laboratoire de Biologie Moleculaire, hôpital Américain, BP 109, 92202 Neuilly, France
    Prenat Diagn 21:85-8. 2001
    The diagnosis of congenital toxoplasmosis frequently relies on PCR tests of amniotic fluid (AF)...
  14. ncbi Prediction of congenital toxoplasmosis by polymerase chain reaction analysis of amniotic fluid
    L Thalib
    Department of Community Medicine and Behavioural Sciences, Faculty of Medicine, Kuwait University, Kuwait
    BJOG 112:567-74. 2005
    ..To determine the accuracy of polymerase chain reaction (PCR) analysis of amniotic fluid for fetal toxoplasmosis according to clinical predictors of outcome and study centre...
  15. ncbi Congenital toxoplasmosis and DALYs in the Netherlands
    L M Kortbeek
    Laboratory for Infectious Diseases and Perinatal Screening, Centre for Infectious Disease Control Netherlands, National Institute for Public Health and Environment, BA Bilthoven, The Netherlands
    Mem Inst Oswaldo Cruz 104:370-3. 2009
    ..The incidence of a disease is important for the calculation of DALYs. To estimate the incidence of congenital toxoplasmosis (CT), a random sample of 10,008 dried blood spot filter paper cards from babies born in 2006 in the ..
  16. ncbi Biases in observational studies of the effect of prenatal treatment for congenital toxoplasmosis
    Rodolphe Thiebaut
    INSERM U593, Institut de Santé Publique, d Epidémiologie et de Développement ISPED, université Bordeaux 2 Victor Segalen, Bordeaux, France
    Eur J Obstet Gynecol Reprod Biol 124:3-9. 2006
    ..Given the limitations of existing observational studies and lack of randomised controlled trials, a systematic review of cohort studies offers the best approach for exploring potential biases...
  17. pmc Use of recombinant antigens for early postnatal diagnosis of congenital toxoplasmosis
    Wilma Buffolano
    Kenton Laboratories, Via Pontina Km 30 400, 00040 Rome, Italy
    J Clin Microbiol 43:5916-24. 2005
    ..anti-MIC2 and anti-SAG1 immunoglobulin G, mainly of the IgG2 subtype, in 13 out of 20 infants with congenital toxoplasmosis. IgM antibodies in 97% of infected infants reacted with at least one of the recombinant antigens, ..
  18. ncbi Hearing loss in congenital toxoplasmosis detected by newborn screening
    Gláucia Manzan Queiroz de Andrade
    Depto Pediatria, FM, UFMG, Belo Horizonte, MG, Brazil
    Braz J Otorhinolaryngol 74:21-8. 2008
    b>Congenital toxoplasmosis may cause sensorineural deficit in up to 20% of the patients and proper treatment in the first year improves prognosis. In Brazil, this infections impact on hearing impairment is unknown.
  19. pmc Toxopain-1 is critical for infection in a novel chicken embryo model of congenital toxoplasmosis
    Xuchu Que
    Departments of Pathology and Medicine, University of California, San Diego, California 92103 8416, USA
    Infect Immun 72:2915-21. 2004
    ..results to the role of toxopain-1 in pathogenesis in vivo, we developed a novel chicken embryo model of congenital toxoplasmosis. Inhibiting either toxopain-1 expression or specific cysteine proteinase activity significantly reduced ..
  20. pmc Ecological comparison of the risks of mother-to-child transmission and clinical manifestations of congenital toxoplasmosis according to prenatal treatment protocol
    R Gilbert
    Department of Epidemiology and Public Health, Institute of Child Health, London, UK
    Epidemiol Infect 127:113-20. 2001
    ..relative risks of mother-to-child transmission of Toxoplasma gondii and clinical manifestations due to congenital toxoplasmosis associated with intensive prenatal treatment in Lyon and Austria, short term treatment in 51% of Dutch ..
  21. pmc Congenital toxoplasmosis: systematic review of evidence of efficacy of treatment in pregnancy
    M Wallon
    Service de Parasitologie, Hopital de la Croix Rousse, 69004 Lyons, France
    BMJ 318:1511-4. 1999
    ..To summarise the evidence that treating toxoplasmosis in pregnancy reduces the risk of congenital toxoplasma infection and improves infant outcomes...
  22. ncbi Neuroendocrine abnormalities in a neonate with congenital toxoplasmosis
    Tania Siahanidou
    Neonatal Unit, First Department of Pediatrics, Athens University, Aghia Sophia Children s Hospital, Athens, Greece
    J Pediatr Endocrinol Metab 19:1363-6. 2006
    The central nervous system is often affected in patients with congenital toxoplasmosis. However, hypothalamo-pituitary dysfunction has rarely been reported in children with congenital toxoplasmosis, and no case with prolonged fever of ..
  23. ncbi Association between prenatal treatment and clinical manifestations of congenital toxoplasmosis in infancy: a cohort study in 13 European centres
    Luuk Gras
    Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, 30 Guilford Street, London, WC1N 1EH, UK
    Acta Paediatr 94:1721-31. 2005
    To determine the effectiveness of prenatal treatment for clinical manifestations of congenital toxoplasmosis.
  24. pmc Value of prenatal diagnosis and early postnatal diagnosis of congenital toxoplasmosis: retrospective study of 110 cases
    F Robert-Gangneux
    Laboratoire de Parasitologie, Centre Hospitalier Universitaire Cochin Port Royal, Paris, France
    J Clin Microbiol 37:2893-8. 1999
    ..follow-up of the infants was conducted during the first year of life or until the diagnosis of congenital toxoplasmosis (CT) could be ruled out...
  25. ncbi Congenital toxoplasmosis: evaluation of serological methods for the detection of anti-Toxoplasma gondii IgM and IgA antibodies
    I M X Rodrigues
    Hospital das Clinicas, Universidade Federal de Goias, Goiania, GO, Brasil
    Mem Inst Oswaldo Cruz 104:434-40. 2009
    ..and predictive values (positive and negative) of different serological methods for the early diagnosis of congenital toxoplasmosis. In a prospective longitudinal study, 50 infants with suspected congenital toxoplasmosis were followed up ..
  26. ncbi When are we going to celebrate the centenary of the discovery of efficient treatment for congenital toxoplasmosis?
    F Peyron
    Laboratoire de Parasitologie et Pathologie Exotique, hôpital de Croix Rousse, Lyon, France
    Mem Inst Oswaldo Cruz 104:316-9. 2009
    ..We must make progress in this field through well-designed collaborative studies and by drawing the attention of policy makers to this disastrous and unsustainable situation...
  27. ncbi Congenital toxoplasmosis in southeastern Brazil: results of early ophthalmologic examination of a large cohort of neonates
    Daniel Vítor Vasconcelos-Santos
    Uveitis Unit, Hospital São Geraldo HC Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
    Ophthalmology 116:2199-205.e1. 2009
    To report results of early ophthalmologic examinations in a large cohort of newborns with congenital toxoplasmosis (CT) after neonatal screening.
  28. ncbi Congenital toxoplasmosis: priorities for further health promotion action
    H M Elsheikha
    Division of Veterinary Medicine, The University of Nottingham, Leicestershire LE12 5RD, UK
    Public Health 122:335-53. 2008
    ....
  29. pmc Genetic and epigenetic factors at COL2A1 and ABCA4 influence clinical outcome in congenital toxoplasmosis
    Sarra E Jamieson
    Cambridge Institute for Medical Research and Department of Medicine, University of Cambridge School of Clinical Medicine, Addenbrookes Hospital, Cambridge, United Kingdom
    PLoS ONE 3:e2285. 2008
    ..Whilst severity of disease is influenced by trimester in which infection is acquired by the mother, other factors including genetic predisposition may contribute...
  30. ncbi Epidemiology of congenital toxoplasmosis identified by population-based newborn screening in Massachusetts
    M Jara
    Bureau of Communicable Disease Control, Massachusetts Department of Public Health, USA
    Pediatr Infect Dis J 20:1132-5. 2001
    BACKGROUND: Fourteen years of newborn screening in Massachusetts for congenital toxoplasmosis infection identified subpopulations that appeared to have higher rates of infection...
  31. pmc Effect of Toxoplasma gondii infection kinetics on trophoblast cell population in Calomys callosus, a model of congenital toxoplasmosis
    E A V Ferro
    Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Brazil 05508 900
    Infect Immun 70:7089-94. 2002
    ..gondii infection towards the fetal tissues. C. callosus was demonstrated to be a suitable experimental model to study the dynamics of congenital toxoplasmosis.
  32. ncbi Risk factors for retinochoroiditis during the first 2 years of life in infants with treated congenital toxoplasmosis
    Francois Kieffer
    Neonatal Intensive Care Unit and Toxoplasmosis Laboratory, Institut de Puericulture, Paris, France
    Pediatr Infect Dis J 27:27-32. 2008
    Retinochoroiditis is the main complication of congenital toxoplasmosis. Its risk factors have rarely been investigated and were the object of this study.
  33. ncbi Options for clinical trials of pre and post-natal treatments for congenital toxoplasmosis
    Genevieve Chene
    INSERM U897 Epidemiology and Biostatistics, Bordeaux School of Public Health, Bordeaux University, Bordeaux, France
    Mem Inst Oswaldo Cruz 104:299-304. 2009
    Clinical trials comparing different drug regimens and strategies for the treatment of congenital toxoplasmosis and its clinical manifestations in the liveborn child in different clinical settings should aim at formally evaluating the net ..
  34. pmc The national neonatal screening programme for congenital toxoplasmosis in Denmark: results from the initial four years, 1999-2002
    D R Schmidt
    Laboratory of Parasitology, Statens Serum Institut, Artillerivej 5, DK 2300 Copenhagen S, Denmark
    Arch Dis Child 91:661-5. 2006
    To describe the outcome of four years' nationwide neonatal screening for congenital toxoplasmosis in liveborn newborns.
  35. pmc Strategy for diagnosis of congenital toxoplasmosis: evaluation of methods comparing mothers and newborns and standard methods for postnatal detection of immunoglobulin G, M, and A antibodies
    J M Pinon
    Service de Parasitologie-Mycologie, , UPRES EA 2070, IFR53, 51092, Reims, France
    J Clin Microbiol 39:2267-71. 2001
    ..the European Community Biomed 2 program, we evaluated immunologic methods for the postnatal diagnosis of congenital toxoplasmosis (CT)...
  36. ncbi Prenatal diagnosis using polymerase chain reaction on amniotic fluid for congenital toxoplasmosis
    S Romand
    Laboratoire de la Toxoplasmose, Institut de Puericulture de Paris, Paris, France
    Obstet Gynecol 97:296-300. 2001
    To evaluate sensitivity, specificity, and predictive values of a prenatal amniotic fluid (AF) polymerase chain reaction (PCR) test for diagnosis of congenital toxoplasmosis.
  37. ncbi [Congenital toxoplasmosis: different preventative strategies]
    P Ambroise-Thomas
    Service de Parasitologie Mycologie, Centre Hospitalier Universitaire, Grenoble, France
    Arch Pediatr 10:12-4. 2003
  38. ncbi Congenital toxoplasmosis: assessment of risk to newborns in confirmed and uncertain maternal infection
    Mariangela Mombrò
    Neonatal Unit, University of Turin, Via Baiardi 43, 10126 Turin, Italy
    Eur J Pediatr 162:703-6. 2003
    ..immunological status during pregnancy, using the criteria established by the European Research Network on Congenital Toxoplasmosis to define the likelihood of infection in pregnant women. Of the 205 newborns, 60 (29...
  39. pmc Vaccination with Toxoplasma gondii SAG-1 protein is protective against congenital toxoplasmosis in BALB/c mice but not in CBA/J mice
    Valerie Letscher-Bru
    Institut de Parasitologie et de Pathologie Tropicale, INSERM U 392, Faculte de Medecine, Universite de Strasbourg, 67000 Strasbourg, France
    Infect Immun 71:6615-9. 2003
    We evaluated the effect of vaccination with the SAG1 protein of Toxoplasma gondii against congenital toxoplasmosis in mice with different genetic backgrounds...
  40. pmc Prognostic factors for the long-term development of ocular lesions in 327 children with congenital toxoplasmosis
    C Binquet
    Laboratoire de Biostatistique, INSERM EPI 01 06, Faculte de Medecine, 7 bd Jeanne d Arc, 21000 Dijon, France
    Epidemiol Infect 131:1157-68. 2003
    ..high-risk factors associated with the development of ocular lesions in a large cohort of children with congenital toxoplasmosis (CT), irrespective of their gestational age at the time of maternal infection...
  41. ncbi Value of cerebrospinal fluid cytochemical examination for the diagnosis of congenital toxoplasmosis at birth in France
    M Wallon
    Parasitology Department, Hopital de la Croix Rousse, Lyon, France
    Pediatr Infect Dis J 17:705-10. 1998
    ..Our goal was to assess the value of cytochemical examination and to confirm whether using a portion of available CSF for this analysis is legitimate...
  42. pmc Genotyping of Toxoplasma gondii by multiplex PCR and peptide-based serological testing of samples from infants in Poland diagnosed with congenital toxoplasmosis
    Dorota Nowakowska
    Department of Molecular Microbiology, Washington University School of Medicine, 660 S Euclid Ave, Saint Louis, MO 93110, USA
    J Clin Microbiol 44:1382-9. 2006
    ..Here we determined the parasite genotype in amniotic fluid and cerebrospinal fluid samples from congenital toxoplasmosis cases in Poland...
  43. pmc Prevalence of congenital Toxoplasma gondii infection among newborns from the Poznań region of Poland: validation of a new combined enzyme immunoassay for Toxoplasma gondii-specific immunoglobulin A and immunoglobulin M antibodies
    M Paul
    Department of Parasitic and Tropical Diseases, Institute of Microbiology and Infectious Diseases, Karol Marcinkowski University of Medical Sciences, Przybyszewskiego 49, 60 355 Poznan, Poland
    J Clin Microbiol 39:1912-6. 2001
    ..9%. The combined IgA-IgM ELISA is a valuable method for the diagnosis of congenital toxoplasmosis at birth and fulfills criteria for neonatal screening programs...
  44. pmc Significant performance variation among PCR systems in diagnosing congenital toxoplasmosis in São Paulo, Brazil: analysis of 467 amniotic fluid samples
    Thelma Suely Okay
    Laboratory of Medical Investigation, Instituto da Criança, Faculdade de Medicina da Universidade de São Paulo São Paulo SP, Brazil
    Clinics (Sao Paulo) 64:171-6. 2009
    ....
  45. ncbi Prenatal screening and diagnosis of congenital toxoplasmosis: a review of safety issues and psychological consequences for women who undergo screening
    Babak Khoshnood
    INSERM, UMR S149, IFR 69, Epidemiological Research Unit on Perinatal and Women s Health, Villejuif, F 94807 France
    Prenat Diagn 27:395-403. 2007
    ..the EUROTOXO initiative, this review focuses on the potential risks associated with prenatal testing for congenital toxoplasmosis. We first review the evidence on the risks of adverse events associated with amniocentesis, which is ..
  46. ncbi Congenital toxoplasmosis complicated with central diabetes insipidus in the first week of life
    Akihisa Nitta
    J Pediatr 148:283. 2006
  47. ncbi Cord blood screening for congenital toxoplasmosis in northwestern Switzerland, 1982-1999
    Ladina M Signorell
    University Children s Hospital, Basel, Switzerland
    Pediatr Infect Dis J 25:123-8. 2006
    ..In the absence of mandatory nationwide toxoplasmosis screening during pregnancy in Switzerland, the Basel region introduced cord blood screening in 1982...
  48. ncbi Clinical validation of a western blot assay for congenital toxoplasmosis and newborn screening in a hospital in Armenia (Quindio) Colombia
    Carolina Gallego-Marín
    Grupo de Estudio en Parasitología Molecular GEPAMOL, Centro de Investigaciones Biomedicas, Universidad del Quindio, Armenia Q, Colombia
    J Trop Pediatr 52:107-12. 2006
    ..there is no obligatory Toxoplasma screening for pregnant women and both the reporting and follow-up of congenital toxoplasmosis cases is limited, thereby is a public health problem that have no been addressed by health authorities...
  49. ncbi Congenital toxoplasmosis presenting as hypogonadotropic hypogonadism
    P S Suresh Babu
    Department of Pediatrics, J J M Medical College, Davangere, Karnataka, India
    Indian J Pediatr 74:577-9. 2007
    ..Neuroendocrine manifestations of congenital toxoplasmosis are especially uncommon...
  50. ncbi Screening and prevention of congenital toxoplasmosis: an effectiveness study in a population with a high infection rate
    M Ricci
    Neonatology Division, S Giovanni Hospital, Rome, Italy
    J Matern Fetal Neonatal Med 14:398-403. 2003
    Secondary prevention of congenital toxoplasmosis has been attempted by screening pregnant women or by screening neonates...
  51. ncbi Clinical presentation and follow up of children with congenital toxoplasmosis in Brazil
    Marco A P Safadi
    Division of Pediatric Infectious Diseases, Santa Casa de São Paulo School of Medical Sciences, Sao Paulo, SP, Brazil
    Braz J Infect Dis 7:325-31. 2003
    We evaluated the clinical presentation and determined the ocular and neurologic sequelae in children with congenital toxoplasmosis in Brazil, taking into consideration the shortage of national publications on this disease...
  52. ncbi Association between congenital toxoplasmosis and preterm birth, low birthweight and small for gestational age birth
    K Freeman
    Albert Einstein College of Medicine, Bronx, NY, USA
    BJOG 112:31-7. 2005
    To determine the association between congenital toxoplasmosis and preterm birth, low birthweight and small for gestational age birth.
  53. ncbi Congenital toxoplasmosis in the United Kingdom: to screen or not to screen?
    R E Gilbert
    Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, London, UK
    J Med Screen 9:135-41. 2002
    ..In this paper, the extent to which the research evidence on toxoplasma infection meets the criteria that need to be fulfilled for the introduction of screening in the United Kingdom is reviewed...
  54. ncbi Congenital toxoplasmosis in Israel: to screen or not to screen
    Dan Miron
    Department of Pediatrics A, Haemek Medical Center, Afula, Israel
    Isr Med Assoc J 4:119-22. 2002
  55. ncbi Outcome for children infected with congenital toxoplasmosis in the first trimester and with normal ultrasound findings: a study of 36 cases
    Alain Berrebi
    Fédération de Gynécologie Obstétrique, CHU Paule de Viguier, TSA 70034, 31059 Toulouse Cedex 9, France
    Eur J Obstet Gynecol Reprod Biol 135:53-7. 2007
    ..the first trimester of pregnancy and whose ultrasound findings were entirely normal, in order to find out whether congenital toxoplasmosis did or did not justify termination of pregnancy if there was no fetal abnormality on ultrasound.
  56. ncbi Congenital toxoplasmosis
    S Martin
    University of Tennessee Medical Center, Knoxville, USA
    Neonatal Netw 20:23-30. 2001
    ..The focus of this article is congenital toxoplasmosis, which is transmitted to the fetus across the placenta...
  57. pmc Cataracts in congenital toxoplasmosis
    Veena Arun
    Department of Ophthalmology and Visual Sciences, The University of Chicago, Chicago, IL 60637, USA
    J AAPOS 11:551-4. 2007
    To determine the incidence and natural history of cataracts in children with congenital toxoplasmosis.
  58. ncbi Diagnosis of congenital toxoplasmosis at birth: what is the value of testing for IgM and IgA?
    M Wallon
    Service de Parasitologie, Hopital de la Croix Rousse, Lyon, France
    Eur J Pediatr 158:645-9. 1999
    Recommendations vary on the best combination of tests to use for the diagnosis of subclinical congenital toxoplasmosis at birth...
  59. ncbi Cellular and molecular physiopathology of congenital toxoplasmosis: the dual role of IFN-gamma
    A W Pfaff
    Institut de Parasitologie et de Pathologie Tropicale, EA 3950, Universite Louis Pasteur, 3 Rue Koeberle, 67000, Strasbourg, France
    Parasitology 134:1895-902. 2007
    ..In summary, even if the whole process is far from being elucidated, important insights have been gained so far which will help us to undertake rational vaccine research...
  60. pmc Newborn screening for congenital toxoplasmosis: feasible, but benefits are not established
    R Gilbert
    Centre for Epidemiology and Biostatistics, Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
    Arch Dis Child 91:629-31. 2006
  61. ncbi Serological rebound in congenital toxoplasmosis: long-term follow-up of 133 children
    M Wallon
    Service de Parasitologie, Hĵpital de la Croix Rousse, Lyon, France
    Eur J Pediatr 160:534-40. 2001
    Although serological rebound is common in infants with congenital toxoplasmosis, clinical recommendations for management, in particular the need for additional treatment, vary...
  62. ncbi Treatment of infants with congenital toxoplasmosis: tolerability and plasma concentrations of sulfadiazine and pyrimethamine
    Dorte Remmer Schmidt
    Laboratory of Parasitology, Statens Serum Institute, Artillerivej 5, 2300, Copenhagen, Denmark
    Eur J Pediatr 165:19-25. 2006
    ..the tolerability and plasma concentrations of pyrimethamine and sulfadiazine in children treated for congenital toxoplasmosis. Infants were diagnosed through the Danish Toxoplasma Neonatal Screening Programme, based on detection of ..
  63. ncbi Prenatal screening for congenital toxoplasmosis in Campania: preliminary report on activities and results
    L Stagni
    Department of Paediatrics, University Hospital Federico II, Naples, Italy
    Mem Inst Oswaldo Cruz 104:374-7. 2009
    ..mothers with gestational toxoplasmosis had been recruited in the Campania region to monitor the burden of congenital toxoplasmosis (CT)...
  64. ncbi Prenatal diagnosis of congenital toxoplasmosis
    Aris Antsaklis
    First Department of Obstetrics and Gynaecology, Fetal Medicine Unit, Alexandra Hospital, University of Athens, Athens, Greece
    Prenat Diagn 22:1107-11. 2002
    ..serial ultrasonographic scans to detect those fetuses with abnormalities that could be associated with congenital toxoplasmosis. Eighteen pregnancies (19.4%) had evidence of vertical transmission. A total of 11/18 (61...
  65. ncbi A case of congenital toxoplasmosis whose mother demonstrated serum low IgG avidity and positive tests for multiplex-nested PCR in the amniotic fluid
    Akira Nishikawa
    NTT East Sapporo Medical Center, Japan
    J Obstet Gynaecol Res 35:372-8. 2009
    We encountered a woman whose infant developed congenital toxoplasmosis. Serum Toxoplasma gondii antibody titers (320x) at 12 weeks of gestation increased to 5120x at 25 weeks. Toxoplasma immunoglobulin M was 2...
  66. ncbi Sulfadiazine and pyrimethamine in the postnatal treatment of congenital toxoplasmosis: what are the options?
    Eskild Petersen
    Danish Toxoplasma Neonatal Screening Program, WHO FAO International Center for Research and Reference on Toxoplasmosis, Department of Gastrointestinal and Parasitic Infections, Statens Serum Institut, DK 2300 Copenhagen S, Denmark
    Expert Rev Anti Infect Ther 1:175-82. 2003
    Pre- and neonatal screening for congenital toxoplasmosis rests upon the assumption that treatment is beneficial on either acute symptoms or in preventing later reactivation...
  67. ncbi Bax-induced apoptosis not demonstrated in the congenital toxoplasmosis in mice
    J Takahashi
    Division of Neuropathology, Jikei University School of Medicine, 3 25 8, Nishi shim bashi, Minato ku, 105 8461, Tokyo, Japan
    Brain Dev 23:50-3. 2001
    A prominent neuropathological change observed in a murine model of congenital toxoplasmosis is cerebral cortical hypoplasia...
  68. ncbi Ophthalmic outcomes after prenatal and postnatal treatment of congenital toxoplasmosis
    Antoine P Brezin
    Service d ophtalmologie A P B, Hopital Cochin, Paris, France
    Am J Ophthalmol 135:779-84. 2003
    To describe the ophthalmologic outcomes of cases of congenital toxoplasmosis treated prenatally and postnatally.
  69. ncbi A comparative study of congenital toxoplasmosis between public and private hospitals from Uberlândia, MG, Brazil
    Gesmar Rodrigues Silva Segundo
    Laboratorio de Imunoparasitologia, Instituto de Ciencias Biomedicas, Universidade Federal de Uberlandia, Uberlandia, MG, 38400 902, Brasil
    Mem Inst Oswaldo Cruz 99:13-7. 2004
    The main purpose of the present study was to examine if there is difference in terms of incidence rates of congenital toxoplasmosis among populations assisted in public and private hospitals from Uberlândia, state of Minas Gerais, Brazil...
  70. ncbi Effectiveness of prenatal treatment for congenital toxoplasmosis: a meta-analysis of individual patients' data
    Rodolphe Thiebaut
    INSERM, Bordeaux, France
    Lancet 369:115-22. 2007
    Despite three decades of prenatal screening for congenital toxoplasmosis in some European countries, uncertainty remains about the effectiveness of prenatal treatment.
  71. ncbi Congenital toxoplasmosis: a review
    J L Jones
    Centers for Disease Control and Prevention, Atlanta, Georgia 30341 3724, USA
    Obstet Gynecol Surv 56:296-305. 2001
    ..in pregnant women may cause serious health problems when the organism is transmitted to the fetus (congenital toxoplasmosis), including mental retardation, seizures, blindness, and death...
  72. ncbi Exosomes are an effective vaccine against congenital toxoplasmosis in mice
    Celine Beauvillain
    Universite Francois Rabelais de Tours, INRA, 31, Avenue Monge, 37200 Tours, France
    Vaccine 27:1750-7. 2009
    ..gondii infection in a congenital model. They are therefore a potentially useful tool for vaccination against infectious disease...
  73. ncbi Characteristics of a pediatric low-vision population
    K M de Carvalho
    Universidade Estadual de Campinas, Sao Paulo, Brazil
    J Pediatr Ophthalmol Strabismus 35:162-5. 1998
    ..The optical aid most frequently prescribed was a telescope. The improvement of visual acuity with the use of aids was highly significant...
  74. ncbi Treatment for congenital toxoplasmosis: finding out what works
    Ruth Gilbert
    Centre for Paediatric Epidemiology and Biostatistics, UCL, Institute of Child Health, London, UK
    Mem Inst Oswaldo Cruz 104:305-11. 2009
    Evidence for the effectiveness of prenatal or postnatal treatment for congenital toxoplasmosis will be critical to guide policy about prenatal and neonatal screening over the next 10 years, let alone the next 100...
  75. ncbi Congenital toxoplasmosis
    Jeffrey Jones
    Epidemiology Branch, Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30341 3724, USA
    Am Fam Physician 67:2131-8. 2003
    ..An estimated 400 to 4,000 cases of congenital toxoplasmosis occur in the United States each year. Serologic tests are used to diagnose acute T...
  76. ncbi Ocular manifestations in congenital toxoplasmosis
    Laurent Kodjikian
    Department of Ophthalmology, Croix Rousse Hospital, Claude Bernard Lyon I University, Lyon, France
    Graefes Arch Clin Exp Ophthalmol 244:14-21. 2006
    Retinochoroiditis is the most common ocular manifestation of congenital toxoplasmosis, but other associated ophthalmological pathologies can also occur...
  77. ncbi Neonatal screening for congenital toxoplasmosis in a cohort of 165 women infected during pregnancy and influence of in utero treatment on the results of neonatal tests
    M H Bessieres
    Department of Parasitology, CHU, Rangueil 1 Avenue du Professeur Jean Poulhès, 31403 Cedex 4, Toulouse, France
    Eur J Obstet Gynecol Reprod Biol 94:37-45. 2001
    The aim of this study was to determine the performances of methods used for the neonatal diagnosis of congenital toxoplasmosis. We included 165 pregnant women infected during pregnancy over a 10-year period...
  78. ncbi Retinochoroiditis associated with congenital toxoplasmosis in children: IgG antibody profiles demonstrating the synthesis of local antibodies
    R de Marco
    Department of Infectious Diseases, University of Genova, Genova, Italy
    Eur J Ophthalmol 13:74-9. 2003
    Retinochoroiditis is generally diagnosed after the first year of life and the association with congenital toxoplasmosis presents a diagnostic dilemma. The detection of local intraocular specific antibodies could be useful for diagnosis.
  79. ncbi Longitudinal study of new eye lesions in treated congenital toxoplasmosis
    Laura Phan
    University of Chicago School of Medicine, Chicago, Illinois 60637, USA
    Ophthalmology 115:553-559.e8. 2008
    To determine the incidence of new chorioretinal lesions in patients with congenital toxoplasmosis who were treated throughout their first year of life.
  80. ncbi Kinetic analysis of the humoral immune response against 3 Toxoplasma gondii-recombinant proteins in infants with suspected congenital toxoplasmosis
    Jaime Altcheh
    Parasitologia, Hospital de Ninos Ricardo Gutierrez, Buenos Aires 1429, Argentina
    Diagn Microbiol Infect Dis 56:161-5. 2006
    ..The potential of the utility of rAgs to develop a diagnostic system that discriminates congenitally I infants from NI is discussed...
  81. ncbi In utero and at birth diagnosis of congenital toxoplasmosis: use of likelihood ratios for clinical management
    Muriel Rabilloud
    Hospices Civils de Lyon, Service de Biostatistique, Lyon, France
    Pediatr Infect Dis J 29:421-5. 2010
    The results of the ante- and neonatal diagnostic tests for congenital toxoplasmosis influence the decision to treat the newborn immediately after birth...
  82. ncbi Histopathological features of ocular toxoplasmosis in the fetus and infant
    F Roberts
    Department of Medicine, Michael Reese Hospital, Chicago, IL, USA
    Arch Ophthalmol 119:51-8. 2001
    ..of our study was to characterize histopathological features in the eyes of 10 fetuses and 2 infants with congenital toxoplasmosis. METHODS: Fifteen eyes from 10 fetuses, 3 eyes from 2 premature infants, and both eyes from a 2-year-old ..
  83. ncbi A second European collaborative study on polymerase chain reaction for Toxoplasma gondii, involving 15 teams
    H Pelloux
    Department of Parasitology and Mycology, University Hospital, Grenoble, France
    FEMS Microbiol Lett 165:231-7. 1998
    ..the accuracy and practicability of the polymerase chain reaction (PCR) in the antenatal diagnosis of congenital toxoplasmosis, a collaborative study involving 15 European laboratories was performed under the auspices of the Biomed ..
  84. ncbi Refinement of the mouse model of congenital toxoplasmosis
    A Freyre
    Laboratory for Toxoplasmosis, Department of Parasitology, College for Veterinary Sciences, Montevideo, Uruguay
    Exp Parasitol 113:154-60. 2006
    The goals of the present investigation, focusing on the BALB/c mouse model of congenital toxoplasmosis, were: (1) to find a method to determine pregnancy in the mouse...
  85. pmc Direct genotypic characterization of Toxoplasma gondii strains associated with congenital toxoplasmosis in Tunisia (North Africa)
    Sonia Boughattas
    Laboratoire de Recherche 05SP03, Laboratoire de Parasitologie, Institut Pasteur de Tunis, Tunis, Tunisia
    Am J Trop Med Hyg 82:1041-6. 2010
    ..the Toxoplasma gondii genotype in amniotic fluid, placenta, and cerebrospinal fluid samples from 14 congenital toxoplasmosis cases in Tunisia, North Africa. Direct genotypic characterization of T...
  86. ncbi Time to screen for congenital toxoplasmosis?
    Kami Kim
    Clin Infect Dis 42:1395-7. 2006
  87. pmc Multicenter evaluation of a fluorometric enzyme immunocapture assay to detect toxoplasma-specific immunoglobulin M in dried blood filter paper specimens from newborns
    R B Eaton
    New England Regional Newborn Screening Program, State Laboratory Institute, Jamaica Plain, Massachusetts 02130 3523, USA
    J Clin Microbiol 34:3147-50. 1996
    ..These results demonstrate that the IgM FEIA is a potential alternative to other filter paper assay for toxoplasma-specific IgM currently in use for newborns...
  88. ncbi Diagnosis of congenital toxoplasmosis: prenatal and neonatal evaluation of methods used in Toulouse University Hospital and incidence of congenital toxoplasmosis
    M H Bessieres
    Department of Parasitology and Mycology, Hopital de Rangueil, Centre Hospitalier Universitaire de Toulouse, 1 avenue Jean Poulhes, 31059 Toulouse, France
    Mem Inst Oswaldo Cruz 104:389-92. 2009
    The aim of this study was to determine the incidence of congenital toxoplasmosis (CT) and to assess the performances of prenatal and neonatal diagnoses...
  89. ncbi High prevalence of congenital toxoplasmosis in Brazil estimated in a 3-year prospective neonatal screening study
    E C Neto
    Centro de Triagem Neonatal and Laboratório Nobel RIE Av Ipiranga, 5 000, Porto Alegre, RS, 90 610 000, Brazil
    Int J Epidemiol 29:941-7. 2000
    A pilot neonatal screening programme revealed a high (approximately 1 per 4800 live births) prevalence of congenital toxoplasmosis (CT) in the State of Rio Grande do Sul, Brazil...
  90. ncbi Congenital toxoplasmosis--prenatal aspects of Toxoplasma gondii infection
    Efrat Rorman
    National Public Health Laboratory, Ministry of Health, Tel Aviv, Israel
    Reprod Toxicol 21:458-72. 2006
    ..Vertical transmission from a recently infected pregnant woman to her fetus may lead to congenital toxoplasmosis. The risk of such transmission increases as primary maternal infection occurs later in pregnancy...
  91. ncbi Mic1-3 knockout of Toxoplasma gondii is a successful vaccine against chronic and congenital toxoplasmosis in mice
    Alaa Bassuny Ismael
    Universite Francois Rabelais de Tours, Institut National de la Recherche Agronomique INRA, 37200 Tours, France
    J Infect Dis 194:1176-83. 2006
    We evaluated a new vaccine, Mic1-3KO, against both chronic and congenital toxoplasmosis in mice. Mic1-3KO is a mutant strain of Toxoplasma gondii RH that lacks the mic1 and mic3 genes.
  92. ncbi Risk of visual impairment in children with congenital toxoplasmic retinochoroiditis
    Hooi Kuan Tan
    Centre for Pediatric Epidemiology and Biostatistics, Institute of Child Health, University College London, London, United Kingdom
    Am J Ophthalmol 144:648-653. 2007
    Reliable information is needed to counsel parents of children with congenital toxoplasmosis regarding the long-term risk of visual impairment resulting from ocular toxoplasmosis.
  93. ncbi Precocious puberty: an endocrine manifestation in congenital toxoplasmosis
    Nuvarte Setian
    Pediatric Endocrinology Unit, Instituto da Crianca Hospital das Clinicas, Sao Paulo University School of Medicine, Brazil
    J Pediatr Endocrinol Metab 15:1487-90. 2002
    We reviewed retrospectively seven children with congenital toxoplasmosis and precocious puberty. All seven showed very high levels of LH (25.2-155.0 IU/ml) and FSH (7.1-38.2) upon stimulation with GnRH...
  94. pmc Comparison of two widely used PCR primer systems for detection of toxoplasma in amniotic fluid, blood, and tissues
    Elisabeth Chabbert
    Laboratoire de Parasitologie Mycologie, Centre Hospitalier Universitaire, Montpellier, France
    J Clin Microbiol 42:1719-22. 2004
    ..Nevertheless, when clinical samples were tested, both methods significantly differed in their technical sensitivities and specificities. Only one method appeared adequate for samples containing blood or tissue...
  95. pmc Population pharmacokinetics of pyrimethamine and sulfadoxine in children with congenital toxoplasmosis
    T Trenque
    Laboratoire de Pharmacologie Toxicologie, CHU, Reims, France
    Br J Clin Pharmacol 57:735-41. 2004
    To develop a population pharmacokinetic model for pyrimethamine (PYR) and sulfadoxine (SDX) in children with congenital toxoplasmosis.
  96. ncbi Long-term ocular prognosis in 327 children with congenital toxoplasmosis
    Martine Wallon
    Department of Parasitology, Hopital de la Croix Rousse, Lyon, France
    Pediatrics 113:1567-72. 2004
    Retinochoroiditis is the most frequent consequence of congenital toxoplasmosis. Early diagnosis and treatment are believed to reduce the risk of visual impairment...
  97. ncbi Early and accurate diagnosis of congenital toxoplasmosis
    Laura Ciardelli
    Research Laboratories Neonatal Immunology and Paediatric Oncohematology, University of Pavia, Italy
    Pediatr Infect Dis J 27:125-9. 2008
    ..We explored specific T cell immunity to Toxoplasma gondii antigens to identify more accurate diagnostic tests for an early diagnosis of toxoplasma infection in newborns at risk for congenital toxoplasmosis.
  98. ncbi Congenital toxoplasmosis: late pregnancy infections detected by neonatal screening and maternal serological testing at delivery
    Eleonor G Lago
    Department of Pediatrics, Pontificia Universidade Catolica do Rio Grande do Sul, Porto Alegre, Brazil
    Paediatr Perinat Epidemiol 21:525-31. 2007
    The first aim of this study was to determine the prevalence of congenital toxoplasmosis in newborn infants treated by the public health system in Porto Alegre, a city in southern Brazil, using neonatal screening for Toxoplasma gondii-..
  99. ncbi Congenital toxoplasmosis: specific IgG subclasses in mother/newborn pairs
    Irma Cañedo-Solares
    Inmunología Experimental, Subdirección de Medicina Experimental, Instituto Nacional de Pediatria, Secretaria de Salud, Mexico DF
    Pediatr Infect Dis J 27:469-74. 2008
    ..IgG subclasses may be markers of congenital infection or clinical outcome...
  100. pmc Diagnosis of congenital toxoplasmosis: comparison of targets for detection of Toxoplasma gondii by PCR
    Denis Filisetti
    Institut de Parasitologie et de Pathologie Tropicale, Strasbourg, France
    J Clin Microbiol 41:4826-8. 2003
    ..ribosomal DNA, B1, and AF146527) and mouse inoculation were compared for 83 samples in the context of congenital toxoplasmosis. These four techniques are not statistically different in terms of sensitivity and specificity...
  101. pmc Determinants of response to a parent questionnaire about development and behaviour in 3 year olds: European multicentre study of congenital toxoplasmosis
    A Salt
    The Neurodisability Service, Great Ormond Street Hospital for Children and Institute of Child Health, London, UK
    BMC Pediatr 5:21. 2005
    ..We aimed to determine how response to a parent-completed postal questionnaire measuring development, behaviour, impairment, and parental concerns and anxiety, varies in different European centres...

Research Grants16

  1. Development of an Inhibitor of Toxoplasma gondii
    Richard D Wood; Fiscal Year: 2010
    ..b>Congenital toxoplasmosis is a devastating infection that occurs when a pregnant woman acquires T...
  2. Innate Immune Receptors for Toxoplasma gondii
    Ricardo Gazzinelli; Fiscal Year: 2010
    ..gondii in humans, we will characterize TLRs in patients with congenital toxoplasmosis and their parents, and in patients with ocular toxoplasmosis that remains stable or that recurs ..
  3. SURFACE PROTEINS OF TOXOPLASMA GONDII
    Gary Ward; Fiscal Year: 2002
    ..As many as 4000 children are born each year in the USA with congenital toxoplasmosis, the symptoms of which range from impaired vision to hydrocephalus and death. T...
  4. CONGENITAL TOXOPLASMOSIS & MATERNAL HIV-1 INFECTION
    Charles Mitchell; Fiscal Year: 1991
    ..with both the Human Immunodeficiency Virus Type I(HIV- 1) and Toxoplasma are at increased risk for congenital toxoplasmosis. As opposed to the usual clinical situation where congenital Toxoplasma infection occurs only when the ..
  5. TOXOPLASMOSIS--INFECTION AND IMMUNE RESPONSE
    Jack Remington; Fiscal Year: 2001
    ..recognized by the fetus but not by their mothers will be further examined to improve diagnosis of congenital toxoplasmosis. A new model of toxoplasmosis in mice genetically resistant to development of toxoplasmic encephalitis (..
  6. IFN Inhibition of Toxoplasma gondii in Astrocytes
    SANDRA HALONEN; Fiscal Year: 2006
    ..that is a common infection in AIDS patients and other immunocompromised individuals as well as the cause congenital toxoplasmosis. In AIDS patients and other immunocompromised hosts infection is due to reactivation of a latent ..
  7. IFN Immune Effector Mechanisms in Cerebral Toxoplasmosis
    SANDRA HALONEN; Fiscal Year: 2006
    ..protozoan parasite that is a major opportunistic infection in immunocompromised individuals, the cause of congenital toxoplasmosis in newborns and recently has been identified as a potential bioterrorism agent (list B)...
  8. ARTEMISININ ANALOGS FOR THE TREATMENT OF TOXOPLASMOSIS
    TIMOTHY ZIEBARTH; Fiscal Year: 1992
    ..Millions of dollars are needed each year to care for victims of congenital toxoplasmosis in the United States alone, and toxoplasmic encephalitis is now the most commonly recognized cause of ..
  9. Outcomes in congenital toxoplasmic retinochoroiditis
    Ruth Gilbert; Fiscal Year: 2005
    The study aims to increase understanding of the determinants of retinochoroiditis in children with congenital toxoplasmosis and the consequences for visual outcomes...
  10. TREATMENT OF CONGENITAL TOXOPLASMOSIS
    Rima L McLeod; Fiscal Year: 2010
    ..Hypotheses are that treatment of congenital toxoplasmosis during the first year of life will improve outcome into the second decade of life, treatment will not be ..
  11. NOVEL APICOMPLEXAN METABOLISM AND ORGANELLE TRANSIT
    Rima McLeod; Fiscal Year: 2005
    ..gondii, its gene regulation, organelle targeting and better characterization of possible novel antimicrobial agent targets in the shikimate pathway and its branches. ..
  12. Prenatal Factors and Risk of Bipolar Disorder
    ALAN STEWART BROWN; Fiscal Year: 2010
    ....
  13. DEVELOPMENTAL INSULT AND BRAIN ANOMALY IN SCHIZOPHRENIA
    Alan Brown; Fiscal Year: 2004
    ....
  14. Short Tandem Repeat Polymorphisms in Cytomegalovirus
    James Bale; Fiscal Year: 2003
    ..Characterizing HCM' strains by STR analysis will facilitate future studies of HCMV evolution and will provide a novel means t to fingerprint HCMV strains. ..
  15. Serologic Studies of Prenatal Factors in Schizophrenia
    Alan Brown; Fiscal Year: 2002
    ..For this purpose, we shall quantify levels of these cytokines in 100 SSD cases and their respective matched controls, and compare these levels between the groups. ..
  16. Prenatal factors and risk of autism in a Finnish national birth cohort
    ALAN STEWART BROWN; Fiscal Year: 2010
    ....