Summary: Prenatal protozoal infection with TOXOPLASMA gondii which is associated with injury to the developing fetal nervous system. The severity of this condition is related to the stage of pregnancy during which the infection occurs; first trimester infections are associated with a greater degree of neurologic dysfunction. Clinical features include HYDROCEPHALUS; MICROCEPHALY; deafness; cerebral calcifications; SEIZURES; and psychomotor retardation. Signs of a systemic infection may also be present at birth, including fever, rash, and hepatosplenomegaly. (From Adams et al., Principles of Neurology, 6th ed, p735)
Publications227 found, 100 shown here
- Outcome of treatment for congenital toxoplasmosis, 1981-2004: the National Collaborative Chicago-Based, Congenital Toxoplasmosis StudyRima McLeod
Department of Ophthalmology and Visual Sciences, University of Chicago, Chicago, Illinois 60637, USA
Clin Infect Dis 42:1383-94. 2006Without treatment, congenital toxoplasmosis has recurrent, recrudescent, adverse outcomes...
- Incidence of congenital toxoplasmosis estimated by neonatal screening: relevance of diagnostic confirmation in asymptomatic newborn infantsC G Carvalheiro
Department of Pediatrics, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Sao Paulo, Brasil
Epidemiol Infect 133:485-91. 2005b>Congenital toxoplasmosis is rarely identified by routine clinical examination. The aim of this study was to estimate the incidence of the disease in the region of Ribeirão Preto, south-eastern Brazil...
- Genotype of 86 Toxoplasma gondii isolates associated with human congenital toxoplasmosis, and correlation with clinical findingsDaniel Ajzenberg
Service de Parasitologie Mycologie, EA 3174, Faculte de Medecine, Limoges, France
J Infect Dis 186:684-9. 2002To study the influence of Toxoplasma gondii genotypes on the severity of human congenital toxoplasmosis (asymptomatic, benign, or severe infection or newborn or fetal death), 8 microsatellite markers were used to analyze 86 T...
- Disease burden of congenital toxoplasmosisA H Havelaar
National Institute for Public Health and the Environment, Netherlands Center for Infectious Disease Control, Bilthoven, The Netherlands
Clin Infect Dis 44:1467-74. 2007..The estimated disease burden of congenital toxoplasmosis in The Netherlands is 620 (range, 220-1900) disability-adjusted life years per year, which is similar to ..
- Impact of health education on knowledge and prevention behavior for congenital toxoplasmosis: the experience in PoznaÅ„, PolandZ S Pawlowski
University of Medical Sciences, , Poland
Health Educ Res 16:493-502. 2001..Toxoplasma gondii is transmitted/acquired was better than the knowledge of individual risk factors for congenital toxoplasmosis. Correct hygienic behaviors in pregnancy were often practised by women who lacked good knowledge of ..
- Congenital toxoplasmosis and reinfection during pregnancy: case report, strain characterization, experimental model of reinfection, and reviewAnnie Elbez-Rubinstein
Service de Neonatologie, Hopital Intercommunal de Creteil, Creteil, France
J Infect Dis 199:280-5. 2009We present a case of disseminated congenital toxoplasmosis in a newborn born to a mother who had been immunized against toxoplasmosis before conception...
- Ocular sequelae of congenital toxoplasmosis in Brazil compared with EuropeRuth E Gilbert
Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, London, United Kingdom
PLoS Negl Trop Dis 2:e277. 2008..Evidence is accumulating that more virulent genotypes of Toxoplasma gondii predominate in South America...
- Prevention of congenital toxoplasmosis in Slovenia by serological screening of pregnant womenJernej Logar
Department of Parasitology, Institute of Microbiology and Immunology, Medical Faculty, University of Ljubljana, Slovenia
Scand J Infect Dis 34:201-4. 2002A programme for the prevention of congenital toxoplasmosis in Slovenia involving the screening of pregnant women for Toxoplasma infection is presented...
- Why prevent, diagnose and treat congenital toxoplasmosis?Rima McLeod
Department of Ophthalmology and Visual Sciences, Committees on Immunology, Genetics, Molecular Medicine, The College, University of Chicago, Chicago, IL 60637, USA
Mem Inst Oswaldo Cruz 104:320-44. 2009..Outcomes of untreated congenital toxoplasmosis include adverse ocular and neurologic sequelae described in different countries and decades...
- Screening for congenital toxoplasmosis: accuracy of immunoglobulin M and immunoglobulin A tests after birthRuth E Gilbert
Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, London, UK
J Med Screen 14:8-13. 2007..To determine the accuracy of postnatal screening for toxoplasma-specific immunoglobulin (Ig) M and IgA...
- Evaluation of protective effect of DNA vaccination with genes encoding antigens GRA4 and SAG1 associated with GM-CSF plasmid, against acute, chronical and congenital toxoplasmosis in miceMarie Noëlle Mévélec
Universite Francois Rabelais de Tours, INRA, UMR 483 Université INRA d Immunologie Parasitaire et Vaccinologie, IFR Agents transmissibles et Infectiologie, UFR des Sciences Pharmaceutiques, 31 Avenue Monge, 37200 Tours, France
Vaccine 23:4489-99. 2005..gondii SAG1 and GRA4 antigens. Our data demonstrated that protection was improved by associating antigens (SAG1 and GRA4) and cytokine (GM-CSF) for further development of a multiantigenic vaccine against toxoplasmosis...
- Risk factors for Toxoplasma gondii infection in mothers of infants with congenital toxoplasmosis: Implications for prenatal management and screeningKenneth M Boyer
Rush University Medical Center, Chicago, Ill, USA
Am J Obstet Gynecol 192:564-71. 2005..whether demographic characteristics, history of exposure to recognized transmission vehicles, or illness that was compatible with acute toxoplasmosis during gestation identified most mothers of infants with congenital toxoplasmosis.
- Prenatal diagnosis of congenital toxoplasmosis by duplex real-time PCR using fluorescence resonance energy transfer hybridization probesJ M Costa
Laboratoire de Biologie Moleculaire, hôpital Américain, BP 109, 92202 Neuilly, France
Prenat Diagn 21:85-8. 2001The diagnosis of congenital toxoplasmosis frequently relies on PCR tests of amniotic fluid (AF)...
- Prediction of congenital toxoplasmosis by polymerase chain reaction analysis of amniotic fluidL Thalib
Department of Community Medicine and Behavioural Sciences, Faculty of Medicine, Kuwait University, Kuwait
BJOG 112:567-74. 2005..To determine the accuracy of polymerase chain reaction (PCR) analysis of amniotic fluid for fetal toxoplasmosis according to clinical predictors of outcome and study centre...
- Congenital toxoplasmosis and DALYs in the NetherlandsL M Kortbeek
Laboratory for Infectious Diseases and Perinatal Screening, Centre for Infectious Disease Control Netherlands, National Institute for Public Health and Environment, BA Bilthoven, The Netherlands
Mem Inst Oswaldo Cruz 104:370-3. 2009..The incidence of a disease is important for the calculation of DALYs. To estimate the incidence of congenital toxoplasmosis (CT), a random sample of 10,008 dried blood spot filter paper cards from babies born in 2006 in the ..
- Biases in observational studies of the effect of prenatal treatment for congenital toxoplasmosisRodolphe Thiebaut
INSERM U593, Institut de Santé Publique, d Epidémiologie et de Développement ISPED, université Bordeaux 2 Victor Segalen, Bordeaux, France
Eur J Obstet Gynecol Reprod Biol 124:3-9. 2006..Given the limitations of existing observational studies and lack of randomised controlled trials, a systematic review of cohort studies offers the best approach for exploring potential biases...
- Use of recombinant antigens for early postnatal diagnosis of congenital toxoplasmosisWilma Buffolano
Kenton Laboratories, Via Pontina Km 30 400, 00040 Rome, Italy
J Clin Microbiol 43:5916-24. 2005..anti-MIC2 and anti-SAG1 immunoglobulin G, mainly of the IgG2 subtype, in 13 out of 20 infants with congenital toxoplasmosis. IgM antibodies in 97% of infected infants reacted with at least one of the recombinant antigens, ..
- Hearing loss in congenital toxoplasmosis detected by newborn screeningGláucia Manzan Queiroz de Andrade
Depto Pediatria, FM, UFMG, Belo Horizonte, MG, Brazil
Braz J Otorhinolaryngol 74:21-8. 2008b>Congenital toxoplasmosis may cause sensorineural deficit in up to 20% of the patients and proper treatment in the first year improves prognosis. In Brazil, this infections impact on hearing impairment is unknown.
- Toxopain-1 is critical for infection in a novel chicken embryo model of congenital toxoplasmosisXuchu Que
Departments of Pathology and Medicine, University of California, San Diego, California 92103 8416, USA
Infect Immun 72:2915-21. 2004..results to the role of toxopain-1 in pathogenesis in vivo, we developed a novel chicken embryo model of congenital toxoplasmosis. Inhibiting either toxopain-1 expression or specific cysteine proteinase activity significantly reduced ..
- Ecological comparison of the risks of mother-to-child transmission and clinical manifestations of congenital toxoplasmosis according to prenatal treatment protocolR Gilbert
Department of Epidemiology and Public Health, Institute of Child Health, London, UK
Epidemiol Infect 127:113-20. 2001..relative risks of mother-to-child transmission of Toxoplasma gondii and clinical manifestations due to congenital toxoplasmosis associated with intensive prenatal treatment in Lyon and Austria, short term treatment in 51% of Dutch ..
- Congenital toxoplasmosis: systematic review of evidence of efficacy of treatment in pregnancyM Wallon
Service de Parasitologie, Hopital de la Croix Rousse, 69004 Lyons, France
BMJ 318:1511-4. 1999..To summarise the evidence that treating toxoplasmosis in pregnancy reduces the risk of congenital toxoplasma infection and improves infant outcomes...
- Neuroendocrine abnormalities in a neonate with congenital toxoplasmosisTania Siahanidou
Neonatal Unit, First Department of Pediatrics, Athens University, Aghia Sophia Children s Hospital, Athens, Greece
J Pediatr Endocrinol Metab 19:1363-6. 2006The central nervous system is often affected in patients with congenital toxoplasmosis. However, hypothalamo-pituitary dysfunction has rarely been reported in children with congenital toxoplasmosis, and no case with prolonged fever of ..
- Association between prenatal treatment and clinical manifestations of congenital toxoplasmosis in infancy: a cohort study in 13 European centresLuuk Gras
Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, 30 Guilford Street, London, WC1N 1EH, UK
Acta Paediatr 94:1721-31. 2005To determine the effectiveness of prenatal treatment for clinical manifestations of congenital toxoplasmosis.
- Value of prenatal diagnosis and early postnatal diagnosis of congenital toxoplasmosis: retrospective study of 110 casesF Robert-Gangneux
Laboratoire de Parasitologie, Centre Hospitalier Universitaire Cochin Port Royal, Paris, France
J Clin Microbiol 37:2893-8. 1999..follow-up of the infants was conducted during the first year of life or until the diagnosis of congenital toxoplasmosis (CT) could be ruled out...
- Congenital toxoplasmosis: evaluation of serological methods for the detection of anti-Toxoplasma gondii IgM and IgA antibodiesI M X Rodrigues
Hospital das Clinicas, Universidade Federal de Goias, Goiania, GO, Brasil
Mem Inst Oswaldo Cruz 104:434-40. 2009..and predictive values (positive and negative) of different serological methods for the early diagnosis of congenital toxoplasmosis. In a prospective longitudinal study, 50 infants with suspected congenital toxoplasmosis were followed up ..
- When are we going to celebrate the centenary of the discovery of efficient treatment for congenital toxoplasmosis?F Peyron
Laboratoire de Parasitologie et Pathologie Exotique, hôpital de Croix Rousse, Lyon, France
Mem Inst Oswaldo Cruz 104:316-9. 2009..We must make progress in this field through well-designed collaborative studies and by drawing the attention of policy makers to this disastrous and unsustainable situation...
- Congenital toxoplasmosis in southeastern Brazil: results of early ophthalmologic examination of a large cohort of neonatesDaniel Vítor Vasconcelos-Santos
Uveitis Unit, Hospital São Geraldo HC Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
Ophthalmology 116:2199-205.e1. 2009To report results of early ophthalmologic examinations in a large cohort of newborns with congenital toxoplasmosis (CT) after neonatal screening.
- Congenital toxoplasmosis: priorities for further health promotion actionH M Elsheikha
Division of Veterinary Medicine, The University of Nottingham, Leicestershire LE12 5RD, UK
Public Health 122:335-53. 2008....
- Genetic and epigenetic factors at COL2A1 and ABCA4 influence clinical outcome in congenital toxoplasmosisSarra E Jamieson
Cambridge Institute for Medical Research and Department of Medicine, University of Cambridge School of Clinical Medicine, Addenbrookes Hospital, Cambridge, United Kingdom
PLoS ONE 3:e2285. 2008..Whilst severity of disease is influenced by trimester in which infection is acquired by the mother, other factors including genetic predisposition may contribute...
- Epidemiology of congenital toxoplasmosis identified by population-based newborn screening in MassachusettsM Jara
Bureau of Communicable Disease Control, Massachusetts Department of Public Health, USA
Pediatr Infect Dis J 20:1132-5. 2001BACKGROUND: Fourteen years of newborn screening in Massachusetts for congenital toxoplasmosis infection identified subpopulations that appeared to have higher rates of infection...
- Effect of Toxoplasma gondii infection kinetics on trophoblast cell population in Calomys callosus, a model of congenital toxoplasmosisE A V Ferro
Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Brazil 05508 900
Infect Immun 70:7089-94. 2002..gondii infection towards the fetal tissues. C. callosus was demonstrated to be a suitable experimental model to study the dynamics of congenital toxoplasmosis.
- Risk factors for retinochoroiditis during the first 2 years of life in infants with treated congenital toxoplasmosisFrancois Kieffer
Neonatal Intensive Care Unit and Toxoplasmosis Laboratory, Institut de Puericulture, Paris, France
Pediatr Infect Dis J 27:27-32. 2008Retinochoroiditis is the main complication of congenital toxoplasmosis. Its risk factors have rarely been investigated and were the object of this study.
- Options for clinical trials of pre and post-natal treatments for congenital toxoplasmosisGenevieve Chene
INSERM U897 Epidemiology and Biostatistics, Bordeaux School of Public Health, Bordeaux University, Bordeaux, France
Mem Inst Oswaldo Cruz 104:299-304. 2009Clinical trials comparing different drug regimens and strategies for the treatment of congenital toxoplasmosis and its clinical manifestations in the liveborn child in different clinical settings should aim at formally evaluating the net ..
- The national neonatal screening programme for congenital toxoplasmosis in Denmark: results from the initial four years, 1999-2002D R Schmidt
Laboratory of Parasitology, Statens Serum Institut, Artillerivej 5, DK 2300 Copenhagen S, Denmark
Arch Dis Child 91:661-5. 2006To describe the outcome of four years' nationwide neonatal screening for congenital toxoplasmosis in liveborn newborns.
- Strategy for diagnosis of congenital toxoplasmosis: evaluation of methods comparing mothers and newborns and standard methods for postnatal detection of immunoglobulin G, M, and A antibodiesJ M Pinon
Service de Parasitologie-Mycologie, , UPRES EA 2070, IFR53, 51092, Reims, France
J Clin Microbiol 39:2267-71. 2001..the European Community Biomed 2 program, we evaluated immunologic methods for the postnatal diagnosis of congenital toxoplasmosis (CT)...
- Prenatal diagnosis using polymerase chain reaction on amniotic fluid for congenital toxoplasmosisS Romand
Laboratoire de la Toxoplasmose, Institut de Puericulture de Paris, Paris, France
Obstet Gynecol 97:296-300. 2001To evaluate sensitivity, specificity, and predictive values of a prenatal amniotic fluid (AF) polymerase chain reaction (PCR) test for diagnosis of congenital toxoplasmosis.
- [Congenital toxoplasmosis: different preventative strategies]P Ambroise-Thomas
Service de Parasitologie Mycologie, Centre Hospitalier Universitaire, Grenoble, France
Arch Pediatr 10:12-4. 2003
- Congenital toxoplasmosis: assessment of risk to newborns in confirmed and uncertain maternal infectionMariangela Mombrò
Neonatal Unit, University of Turin, Via Baiardi 43, 10126 Turin, Italy
Eur J Pediatr 162:703-6. 2003..immunological status during pregnancy, using the criteria established by the European Research Network on Congenital Toxoplasmosis to define the likelihood of infection in pregnant women. Of the 205 newborns, 60 (29...
- Vaccination with Toxoplasma gondii SAG-1 protein is protective against congenital toxoplasmosis in BALB/c mice but not in CBA/J miceValerie Letscher-Bru
Institut de Parasitologie et de Pathologie Tropicale, INSERM U 392, Faculte de Medecine, Universite de Strasbourg, 67000 Strasbourg, France
Infect Immun 71:6615-9. 2003We evaluated the effect of vaccination with the SAG1 protein of Toxoplasma gondii against congenital toxoplasmosis in mice with different genetic backgrounds...
- Prognostic factors for the long-term development of ocular lesions in 327 children with congenital toxoplasmosisC Binquet
Laboratoire de Biostatistique, INSERM EPI 01 06, Faculte de Medecine, 7 bd Jeanne d Arc, 21000 Dijon, France
Epidemiol Infect 131:1157-68. 2003..high-risk factors associated with the development of ocular lesions in a large cohort of children with congenital toxoplasmosis (CT), irrespective of their gestational age at the time of maternal infection...
- Value of cerebrospinal fluid cytochemical examination for the diagnosis of congenital toxoplasmosis at birth in FranceM Wallon
Parasitology Department, Hopital de la Croix Rousse, Lyon, France
Pediatr Infect Dis J 17:705-10. 1998..Our goal was to assess the value of cytochemical examination and to confirm whether using a portion of available CSF for this analysis is legitimate...
- Genotyping of Toxoplasma gondii by multiplex PCR and peptide-based serological testing of samples from infants in Poland diagnosed with congenital toxoplasmosisDorota Nowakowska
Department of Molecular Microbiology, Washington University School of Medicine, 660 S Euclid Ave, Saint Louis, MO 93110, USA
J Clin Microbiol 44:1382-9. 2006..Here we determined the parasite genotype in amniotic fluid and cerebrospinal fluid samples from congenital toxoplasmosis cases in Poland...
- Prevalence of congenital Toxoplasma gondii infection among newborns from the Poznań region of Poland: validation of a new combined enzyme immunoassay for Toxoplasma gondii-specific immunoglobulin A and immunoglobulin M antibodiesM Paul
Department of Parasitic and Tropical Diseases, Institute of Microbiology and Infectious Diseases, Karol Marcinkowski University of Medical Sciences, Przybyszewskiego 49, 60 355 Poznan, Poland
J Clin Microbiol 39:1912-6. 2001..9%. The combined IgA-IgM ELISA is a valuable method for the diagnosis of congenital toxoplasmosis at birth and fulfills criteria for neonatal screening programs...
- Significant performance variation among PCR systems in diagnosing congenital toxoplasmosis in São Paulo, Brazil: analysis of 467 amniotic fluid samplesThelma Suely Okay
Laboratory of Medical Investigation, Instituto da Criança, Faculdade de Medicina da Universidade de São Paulo São Paulo SP, Brazil
Clinics (Sao Paulo) 64:171-6. 2009....
- Prenatal screening and diagnosis of congenital toxoplasmosis: a review of safety issues and psychological consequences for women who undergo screeningBabak Khoshnood
INSERM, UMR S149, IFR 69, Epidemiological Research Unit on Perinatal and Women s Health, Villejuif, F 94807 France
Prenat Diagn 27:395-403. 2007..the EUROTOXO initiative, this review focuses on the potential risks associated with prenatal testing for congenital toxoplasmosis. We first review the evidence on the risks of adverse events associated with amniocentesis, which is ..
- Congenital toxoplasmosis complicated with central diabetes insipidus in the first week of lifeAkihisa Nitta
J Pediatr 148:283. 2006
- Cord blood screening for congenital toxoplasmosis in northwestern Switzerland, 1982-1999Ladina M Signorell
University Children s Hospital, Basel, Switzerland
Pediatr Infect Dis J 25:123-8. 2006..In the absence of mandatory nationwide toxoplasmosis screening during pregnancy in Switzerland, the Basel region introduced cord blood screening in 1982...
- Clinical validation of a western blot assay for congenital toxoplasmosis and newborn screening in a hospital in Armenia (Quindio) ColombiaCarolina Gallego-Marín
Grupo de Estudio en Parasitología Molecular GEPAMOL, Centro de Investigaciones Biomedicas, Universidad del Quindio, Armenia Q, Colombia
J Trop Pediatr 52:107-12. 2006..there is no obligatory Toxoplasma screening for pregnant women and both the reporting and follow-up of congenital toxoplasmosis cases is limited, thereby is a public health problem that have no been addressed by health authorities...
- Congenital toxoplasmosis presenting as hypogonadotropic hypogonadismP S Suresh Babu
Department of Pediatrics, J J M Medical College, Davangere, Karnataka, India
Indian J Pediatr 74:577-9. 2007..Neuroendocrine manifestations of congenital toxoplasmosis are especially uncommon...
- Screening and prevention of congenital toxoplasmosis: an effectiveness study in a population with a high infection rateM Ricci
Neonatology Division, S Giovanni Hospital, Rome, Italy
J Matern Fetal Neonatal Med 14:398-403. 2003Secondary prevention of congenital toxoplasmosis has been attempted by screening pregnant women or by screening neonates...
- Clinical presentation and follow up of children with congenital toxoplasmosis in BrazilMarco A P Safadi
Division of Pediatric Infectious Diseases, Santa Casa de São Paulo School of Medical Sciences, Sao Paulo, SP, Brazil
Braz J Infect Dis 7:325-31. 2003We evaluated the clinical presentation and determined the ocular and neurologic sequelae in children with congenital toxoplasmosis in Brazil, taking into consideration the shortage of national publications on this disease...
- Association between congenital toxoplasmosis and preterm birth, low birthweight and small for gestational age birthK Freeman
Albert Einstein College of Medicine, Bronx, NY, USA
BJOG 112:31-7. 2005To determine the association between congenital toxoplasmosis and preterm birth, low birthweight and small for gestational age birth.
- Congenital toxoplasmosis in the United Kingdom: to screen or not to screen?R E Gilbert
Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, London, UK
J Med Screen 9:135-41. 2002..In this paper, the extent to which the research evidence on toxoplasma infection meets the criteria that need to be fulfilled for the introduction of screening in the United Kingdom is reviewed...
- Congenital toxoplasmosis in Israel: to screen or not to screenDan Miron
Department of Pediatrics A, Haemek Medical Center, Afula, Israel
Isr Med Assoc J 4:119-22. 2002
- Outcome for children infected with congenital toxoplasmosis in the first trimester and with normal ultrasound findings: a study of 36 casesAlain Berrebi
Fédération de Gynécologie Obstétrique, CHU Paule de Viguier, TSA 70034, 31059 Toulouse Cedex 9, France
Eur J Obstet Gynecol Reprod Biol 135:53-7. 2007..the first trimester of pregnancy and whose ultrasound findings were entirely normal, in order to find out whether congenital toxoplasmosis did or did not justify termination of pregnancy if there was no fetal abnormality on ultrasound.
- Congenital toxoplasmosisS Martin
University of Tennessee Medical Center, Knoxville, USA
Neonatal Netw 20:23-30. 2001..The focus of this article is congenital toxoplasmosis, which is transmitted to the fetus across the placenta...
- Cataracts in congenital toxoplasmosisVeena Arun
Department of Ophthalmology and Visual Sciences, The University of Chicago, Chicago, IL 60637, USA
J AAPOS 11:551-4. 2007To determine the incidence and natural history of cataracts in children with congenital toxoplasmosis.
- Diagnosis of congenital toxoplasmosis at birth: what is the value of testing for IgM and IgA?M Wallon
Service de Parasitologie, Hopital de la Croix Rousse, Lyon, France
Eur J Pediatr 158:645-9. 1999Recommendations vary on the best combination of tests to use for the diagnosis of subclinical congenital toxoplasmosis at birth...
- Cellular and molecular physiopathology of congenital toxoplasmosis: the dual role of IFN-gammaA W Pfaff
Institut de Parasitologie et de Pathologie Tropicale, EA 3950, Universite Louis Pasteur, 3 Rue Koeberle, 67000, Strasbourg, France
Parasitology 134:1895-902. 2007..In summary, even if the whole process is far from being elucidated, important insights have been gained so far which will help us to undertake rational vaccine research...
- Newborn screening for congenital toxoplasmosis: feasible, but benefits are not establishedR Gilbert
Centre for Epidemiology and Biostatistics, Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
Arch Dis Child 91:629-31. 2006
- Serological rebound in congenital toxoplasmosis: long-term follow-up of 133 childrenM Wallon
Service de Parasitologie, Hĵpital de la Croix Rousse, Lyon, France
Eur J Pediatr 160:534-40. 2001Although serological rebound is common in infants with congenital toxoplasmosis, clinical recommendations for management, in particular the need for additional treatment, vary...
- Treatment of infants with congenital toxoplasmosis: tolerability and plasma concentrations of sulfadiazine and pyrimethamineDorte Remmer Schmidt
Laboratory of Parasitology, Statens Serum Institute, Artillerivej 5, 2300, Copenhagen, Denmark
Eur J Pediatr 165:19-25. 2006..the tolerability and plasma concentrations of pyrimethamine and sulfadiazine in children treated for congenital toxoplasmosis. Infants were diagnosed through the Danish Toxoplasma Neonatal Screening Programme, based on detection of ..
- Prenatal screening for congenital toxoplasmosis in Campania: preliminary report on activities and resultsL Stagni
Department of Paediatrics, University Hospital Federico II, Naples, Italy
Mem Inst Oswaldo Cruz 104:374-7. 2009..mothers with gestational toxoplasmosis had been recruited in the Campania region to monitor the burden of congenital toxoplasmosis (CT)...
- Prenatal diagnosis of congenital toxoplasmosisAris Antsaklis
First Department of Obstetrics and Gynaecology, Fetal Medicine Unit, Alexandra Hospital, University of Athens, Athens, Greece
Prenat Diagn 22:1107-11. 2002..serial ultrasonographic scans to detect those fetuses with abnormalities that could be associated with congenital toxoplasmosis. Eighteen pregnancies (19.4%) had evidence of vertical transmission. A total of 11/18 (61...
- A case of congenital toxoplasmosis whose mother demonstrated serum low IgG avidity and positive tests for multiplex-nested PCR in the amniotic fluidAkira Nishikawa
NTT East Sapporo Medical Center, Japan
J Obstet Gynaecol Res 35:372-8. 2009We encountered a woman whose infant developed congenital toxoplasmosis. Serum Toxoplasma gondii antibody titers (320x) at 12 weeks of gestation increased to 5120x at 25 weeks. Toxoplasma immunoglobulin M was 2...
- Sulfadiazine and pyrimethamine in the postnatal treatment of congenital toxoplasmosis: what are the options?Eskild Petersen
Danish Toxoplasma Neonatal Screening Program, WHO FAO International Center for Research and Reference on Toxoplasmosis, Department of Gastrointestinal and Parasitic Infections, Statens Serum Institut, DK 2300 Copenhagen S, Denmark
Expert Rev Anti Infect Ther 1:175-82. 2003Pre- and neonatal screening for congenital toxoplasmosis rests upon the assumption that treatment is beneficial on either acute symptoms or in preventing later reactivation...
- Bax-induced apoptosis not demonstrated in the congenital toxoplasmosis in miceJ Takahashi
Division of Neuropathology, Jikei University School of Medicine, 3 25 8, Nishi shim bashi, Minato ku, 105 8461, Tokyo, Japan
Brain Dev 23:50-3. 2001A prominent neuropathological change observed in a murine model of congenital toxoplasmosis is cerebral cortical hypoplasia...
- Ophthalmic outcomes after prenatal and postnatal treatment of congenital toxoplasmosisAntoine P Brezin
Service d ophtalmologie A P B, Hopital Cochin, Paris, France
Am J Ophthalmol 135:779-84. 2003To describe the ophthalmologic outcomes of cases of congenital toxoplasmosis treated prenatally and postnatally.
- A comparative study of congenital toxoplasmosis between public and private hospitals from Uberlândia, MG, BrazilGesmar Rodrigues Silva Segundo
Laboratorio de Imunoparasitologia, Instituto de Ciencias Biomedicas, Universidade Federal de Uberlandia, Uberlandia, MG, 38400 902, Brasil
Mem Inst Oswaldo Cruz 99:13-7. 2004The main purpose of the present study was to examine if there is difference in terms of incidence rates of congenital toxoplasmosis among populations assisted in public and private hospitals from Uberlândia, state of Minas Gerais, Brazil...
- Effectiveness of prenatal treatment for congenital toxoplasmosis: a meta-analysis of individual patients' dataRodolphe Thiebaut
INSERM, Bordeaux, France
Lancet 369:115-22. 2007Despite three decades of prenatal screening for congenital toxoplasmosis in some European countries, uncertainty remains about the effectiveness of prenatal treatment.
- Congenital toxoplasmosis: a reviewJ L Jones
Centers for Disease Control and Prevention, Atlanta, Georgia 30341 3724, USA
Obstet Gynecol Surv 56:296-305. 2001..in pregnant women may cause serious health problems when the organism is transmitted to the fetus (congenital toxoplasmosis), including mental retardation, seizures, blindness, and death...
- Exosomes are an effective vaccine against congenital toxoplasmosis in miceCeline Beauvillain
Universite Francois Rabelais de Tours, INRA, 31, Avenue Monge, 37200 Tours, France
Vaccine 27:1750-7. 2009..gondii infection in a congenital model. They are therefore a potentially useful tool for vaccination against infectious disease...
- Characteristics of a pediatric low-vision populationK M de Carvalho
Universidade Estadual de Campinas, Sao Paulo, Brazil
J Pediatr Ophthalmol Strabismus 35:162-5. 1998..The optical aid most frequently prescribed was a telescope. The improvement of visual acuity with the use of aids was highly significant...
- Treatment for congenital toxoplasmosis: finding out what worksRuth Gilbert
Centre for Paediatric Epidemiology and Biostatistics, UCL, Institute of Child Health, London, UK
Mem Inst Oswaldo Cruz 104:305-11. 2009Evidence for the effectiveness of prenatal or postnatal treatment for congenital toxoplasmosis will be critical to guide policy about prenatal and neonatal screening over the next 10 years, let alone the next 100...
- Congenital toxoplasmosisJeffrey Jones
Epidemiology Branch, Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30341 3724, USA
Am Fam Physician 67:2131-8. 2003..An estimated 400 to 4,000 cases of congenital toxoplasmosis occur in the United States each year. Serologic tests are used to diagnose acute T...
- Ocular manifestations in congenital toxoplasmosisLaurent Kodjikian
Department of Ophthalmology, Croix Rousse Hospital, Claude Bernard Lyon I University, Lyon, France
Graefes Arch Clin Exp Ophthalmol 244:14-21. 2006Retinochoroiditis is the most common ocular manifestation of congenital toxoplasmosis, but other associated ophthalmological pathologies can also occur...
- Neonatal screening for congenital toxoplasmosis in a cohort of 165 women infected during pregnancy and influence of in utero treatment on the results of neonatal testsM H Bessieres
Department of Parasitology, CHU, Rangueil 1 Avenue du Professeur Jean Poulhès, 31403 Cedex 4, Toulouse, France
Eur J Obstet Gynecol Reprod Biol 94:37-45. 2001The aim of this study was to determine the performances of methods used for the neonatal diagnosis of congenital toxoplasmosis. We included 165 pregnant women infected during pregnancy over a 10-year period...
- Retinochoroiditis associated with congenital toxoplasmosis in children: IgG antibody profiles demonstrating the synthesis of local antibodiesR de Marco
Department of Infectious Diseases, University of Genova, Genova, Italy
Eur J Ophthalmol 13:74-9. 2003Retinochoroiditis is generally diagnosed after the first year of life and the association with congenital toxoplasmosis presents a diagnostic dilemma. The detection of local intraocular specific antibodies could be useful for diagnosis.
- Longitudinal study of new eye lesions in treated congenital toxoplasmosisLaura Phan
University of Chicago School of Medicine, Chicago, Illinois 60637, USA
Ophthalmology 115:553-559.e8. 2008To determine the incidence of new chorioretinal lesions in patients with congenital toxoplasmosis who were treated throughout their first year of life.
- Kinetic analysis of the humoral immune response against 3 Toxoplasma gondii-recombinant proteins in infants with suspected congenital toxoplasmosisJaime Altcheh
Parasitologia, Hospital de Ninos Ricardo Gutierrez, Buenos Aires 1429, Argentina
Diagn Microbiol Infect Dis 56:161-5. 2006..The potential of the utility of rAgs to develop a diagnostic system that discriminates congenitally I infants from NI is discussed...
- In utero and at birth diagnosis of congenital toxoplasmosis: use of likelihood ratios for clinical managementMuriel Rabilloud
Hospices Civils de Lyon, Service de Biostatistique, Lyon, France
Pediatr Infect Dis J 29:421-5. 2010The results of the ante- and neonatal diagnostic tests for congenital toxoplasmosis influence the decision to treat the newborn immediately after birth...
- Histopathological features of ocular toxoplasmosis in the fetus and infantF Roberts
Department of Medicine, Michael Reese Hospital, Chicago, IL, USA
Arch Ophthalmol 119:51-8. 2001..of our study was to characterize histopathological features in the eyes of 10 fetuses and 2 infants with congenital toxoplasmosis. METHODS: Fifteen eyes from 10 fetuses, 3 eyes from 2 premature infants, and both eyes from a 2-year-old ..
- A second European collaborative study on polymerase chain reaction for Toxoplasma gondii, involving 15 teamsH Pelloux
Department of Parasitology and Mycology, University Hospital, Grenoble, France
FEMS Microbiol Lett 165:231-7. 1998..the accuracy and practicability of the polymerase chain reaction (PCR) in the antenatal diagnosis of congenital toxoplasmosis, a collaborative study involving 15 European laboratories was performed under the auspices of the Biomed ..
- Refinement of the mouse model of congenital toxoplasmosisA Freyre
Laboratory for Toxoplasmosis, Department of Parasitology, College for Veterinary Sciences, Montevideo, Uruguay
Exp Parasitol 113:154-60. 2006The goals of the present investigation, focusing on the BALB/c mouse model of congenital toxoplasmosis, were: (1) to find a method to determine pregnancy in the mouse...
- Direct genotypic characterization of Toxoplasma gondii strains associated with congenital toxoplasmosis in Tunisia (North Africa)Sonia Boughattas
Laboratoire de Recherche 05SP03, Laboratoire de Parasitologie, Institut Pasteur de Tunis, Tunis, Tunisia
Am J Trop Med Hyg 82:1041-6. 2010..the Toxoplasma gondii genotype in amniotic fluid, placenta, and cerebrospinal fluid samples from 14 congenital toxoplasmosis cases in Tunisia, North Africa. Direct genotypic characterization of T...
- Time to screen for congenital toxoplasmosis?Kami Kim
Clin Infect Dis 42:1395-7. 2006
- Multicenter evaluation of a fluorometric enzyme immunocapture assay to detect toxoplasma-specific immunoglobulin M in dried blood filter paper specimens from newbornsR B Eaton
New England Regional Newborn Screening Program, State Laboratory Institute, Jamaica Plain, Massachusetts 02130 3523, USA
J Clin Microbiol 34:3147-50. 1996..These results demonstrate that the IgM FEIA is a potential alternative to other filter paper assay for toxoplasma-specific IgM currently in use for newborns...
- Diagnosis of congenital toxoplasmosis: prenatal and neonatal evaluation of methods used in Toulouse University Hospital and incidence of congenital toxoplasmosisM H Bessieres
Department of Parasitology and Mycology, Hopital de Rangueil, Centre Hospitalier Universitaire de Toulouse, 1 avenue Jean Poulhes, 31059 Toulouse, France
Mem Inst Oswaldo Cruz 104:389-92. 2009The aim of this study was to determine the incidence of congenital toxoplasmosis (CT) and to assess the performances of prenatal and neonatal diagnoses...
- High prevalence of congenital toxoplasmosis in Brazil estimated in a 3-year prospective neonatal screening studyE C Neto
Centro de Triagem Neonatal and Laboratório Nobel RIE Av Ipiranga, 5 000, Porto Alegre, RS, 90 610 000, Brazil
Int J Epidemiol 29:941-7. 2000A pilot neonatal screening programme revealed a high (approximately 1 per 4800 live births) prevalence of congenital toxoplasmosis (CT) in the State of Rio Grande do Sul, Brazil...
- Congenital toxoplasmosis--prenatal aspects of Toxoplasma gondii infectionEfrat Rorman
National Public Health Laboratory, Ministry of Health, Tel Aviv, Israel
Reprod Toxicol 21:458-72. 2006..Vertical transmission from a recently infected pregnant woman to her fetus may lead to congenital toxoplasmosis. The risk of such transmission increases as primary maternal infection occurs later in pregnancy...
- Mic1-3 knockout of Toxoplasma gondii is a successful vaccine against chronic and congenital toxoplasmosis in miceAlaa Bassuny Ismael
Universite Francois Rabelais de Tours, Institut National de la Recherche Agronomique INRA, 37200 Tours, France
J Infect Dis 194:1176-83. 2006We evaluated a new vaccine, Mic1-3KO, against both chronic and congenital toxoplasmosis in mice. Mic1-3KO is a mutant strain of Toxoplasma gondii RH that lacks the mic1 and mic3 genes.
- Risk of visual impairment in children with congenital toxoplasmic retinochoroiditisHooi Kuan Tan
Centre for Pediatric Epidemiology and Biostatistics, Institute of Child Health, University College London, London, United Kingdom
Am J Ophthalmol 144:648-653. 2007Reliable information is needed to counsel parents of children with congenital toxoplasmosis regarding the long-term risk of visual impairment resulting from ocular toxoplasmosis.
- Precocious puberty: an endocrine manifestation in congenital toxoplasmosisNuvarte Setian
Pediatric Endocrinology Unit, Instituto da Crianca Hospital das Clinicas, Sao Paulo University School of Medicine, Brazil
J Pediatr Endocrinol Metab 15:1487-90. 2002We reviewed retrospectively seven children with congenital toxoplasmosis and precocious puberty. All seven showed very high levels of LH (25.2-155.0 IU/ml) and FSH (7.1-38.2) upon stimulation with GnRH...
- Comparison of two widely used PCR primer systems for detection of toxoplasma in amniotic fluid, blood, and tissuesElisabeth Chabbert
Laboratoire de Parasitologie Mycologie, Centre Hospitalier Universitaire, Montpellier, France
J Clin Microbiol 42:1719-22. 2004..Nevertheless, when clinical samples were tested, both methods significantly differed in their technical sensitivities and specificities. Only one method appeared adequate for samples containing blood or tissue...
- Population pharmacokinetics of pyrimethamine and sulfadoxine in children with congenital toxoplasmosisT Trenque
Laboratoire de Pharmacologie Toxicologie, CHU, Reims, France
Br J Clin Pharmacol 57:735-41. 2004To develop a population pharmacokinetic model for pyrimethamine (PYR) and sulfadoxine (SDX) in children with congenital toxoplasmosis.
- Long-term ocular prognosis in 327 children with congenital toxoplasmosisMartine Wallon
Department of Parasitology, Hopital de la Croix Rousse, Lyon, France
Pediatrics 113:1567-72. 2004Retinochoroiditis is the most frequent consequence of congenital toxoplasmosis. Early diagnosis and treatment are believed to reduce the risk of visual impairment...
- Early and accurate diagnosis of congenital toxoplasmosisLaura Ciardelli
Research Laboratories Neonatal Immunology and Paediatric Oncohematology, University of Pavia, Italy
Pediatr Infect Dis J 27:125-9. 2008..We explored specific T cell immunity to Toxoplasma gondii antigens to identify more accurate diagnostic tests for an early diagnosis of toxoplasma infection in newborns at risk for congenital toxoplasmosis.
- Congenital toxoplasmosis: late pregnancy infections detected by neonatal screening and maternal serological testing at deliveryEleonor G Lago
Department of Pediatrics, Pontificia Universidade Catolica do Rio Grande do Sul, Porto Alegre, Brazil
Paediatr Perinat Epidemiol 21:525-31. 2007The first aim of this study was to determine the prevalence of congenital toxoplasmosis in newborn infants treated by the public health system in Porto Alegre, a city in southern Brazil, using neonatal screening for Toxoplasma gondii-..
- Congenital toxoplasmosis: specific IgG subclasses in mother/newborn pairsIrma Cañedo-Solares
Inmunología Experimental, Subdirección de Medicina Experimental, Instituto Nacional de Pediatria, Secretaria de Salud, Mexico DF
Pediatr Infect Dis J 27:469-74. 2008..IgG subclasses may be markers of congenital infection or clinical outcome...
- Diagnosis of congenital toxoplasmosis: comparison of targets for detection of Toxoplasma gondii by PCRDenis Filisetti
Institut de Parasitologie et de Pathologie Tropicale, Strasbourg, France
J Clin Microbiol 41:4826-8. 2003..ribosomal DNA, B1, and AF146527) and mouse inoculation were compared for 83 samples in the context of congenital toxoplasmosis. These four techniques are not statistically different in terms of sensitivity and specificity...
- Determinants of response to a parent questionnaire about development and behaviour in 3 year olds: European multicentre study of congenital toxoplasmosisA Salt
The Neurodisability Service, Great Ormond Street Hospital for Children and Institute of Child Health, London, UK
BMC Pediatr 5:21. 2005..We aimed to determine how response to a parent-completed postal questionnaire measuring development, behaviour, impairment, and parental concerns and anxiety, varies in different European centres...
- Development of an Inhibitor of Toxoplasma gondiiRichard D Wood; Fiscal Year: 2010..b>Congenital toxoplasmosis is a devastating infection that occurs when a pregnant woman acquires T...
- Innate Immune Receptors for Toxoplasma gondiiRicardo Gazzinelli; Fiscal Year: 2010..gondii in humans, we will characterize TLRs in patients with congenital toxoplasmosis and their parents, and in patients with ocular toxoplasmosis that remains stable or that recurs ..
- SURFACE PROTEINS OF TOXOPLASMA GONDIIGary Ward; Fiscal Year: 2002..As many as 4000 children are born each year in the USA with congenital toxoplasmosis, the symptoms of which range from impaired vision to hydrocephalus and death. T...
- CONGENITAL TOXOPLASMOSIS & MATERNAL HIV-1 INFECTIONCharles Mitchell; Fiscal Year: 1991..with both the Human Immunodeficiency Virus Type I(HIV- 1) and Toxoplasma are at increased risk for congenital toxoplasmosis. As opposed to the usual clinical situation where congenital Toxoplasma infection occurs only when the ..
- TOXOPLASMOSIS--INFECTION AND IMMUNE RESPONSEJack Remington; Fiscal Year: 2001..recognized by the fetus but not by their mothers will be further examined to improve diagnosis of congenital toxoplasmosis. A new model of toxoplasmosis in mice genetically resistant to development of toxoplasmic encephalitis (..
- IFN Inhibition of Toxoplasma gondii in AstrocytesSANDRA HALONEN; Fiscal Year: 2006..that is a common infection in AIDS patients and other immunocompromised individuals as well as the cause congenital toxoplasmosis. In AIDS patients and other immunocompromised hosts infection is due to reactivation of a latent ..
- IFN Immune Effector Mechanisms in Cerebral ToxoplasmosisSANDRA HALONEN; Fiscal Year: 2006..protozoan parasite that is a major opportunistic infection in immunocompromised individuals, the cause of congenital toxoplasmosis in newborns and recently has been identified as a potential bioterrorism agent (list B)...
- ARTEMISININ ANALOGS FOR THE TREATMENT OF TOXOPLASMOSISTIMOTHY ZIEBARTH; Fiscal Year: 1992..Millions of dollars are needed each year to care for victims of congenital toxoplasmosis in the United States alone, and toxoplasmic encephalitis is now the most commonly recognized cause of ..
- Outcomes in congenital toxoplasmic retinochoroiditisRuth Gilbert; Fiscal Year: 2005The study aims to increase understanding of the determinants of retinochoroiditis in children with congenital toxoplasmosis and the consequences for visual outcomes...
- TREATMENT OF CONGENITAL TOXOPLASMOSISRima L McLeod; Fiscal Year: 2010..Hypotheses are that treatment of congenital toxoplasmosis during the first year of life will improve outcome into the second decade of life, treatment will not be ..
- NOVEL APICOMPLEXAN METABOLISM AND ORGANELLE TRANSITRima McLeod; Fiscal Year: 2005..gondii, its gene regulation, organelle targeting and better characterization of possible novel antimicrobial agent targets in the shikimate pathway and its branches. ..
- Prenatal Factors and Risk of Bipolar DisorderALAN STEWART BROWN; Fiscal Year: 2010....
- DEVELOPMENTAL INSULT AND BRAIN ANOMALY IN SCHIZOPHRENIAAlan Brown; Fiscal Year: 2004....
- Short Tandem Repeat Polymorphisms in CytomegalovirusJames Bale; Fiscal Year: 2003..Characterizing HCM' strains by STR analysis will facilitate future studies of HCMV evolution and will provide a novel means t to fingerprint HCMV strains. ..
- Serologic Studies of Prenatal Factors in SchizophreniaAlan Brown; Fiscal Year: 2002..For this purpose, we shall quantify levels of these cytokines in 100 SSD cases and their respective matched controls, and compare these levels between the groups. ..
- Prenatal factors and risk of autism in a Finnish national birth cohortALAN STEWART BROWN; Fiscal Year: 2010....