Genomes and Genes
positive pressure respiration
Summary: A method of mechanical ventilation in which pressure is maintained to increase the volume of gas remaining in the lungs at the end of expiration, thus reducing the shunting of blood through the lungs and improving gas exchange.
Publications285 found, 100 shown here
- Respiratory controversies in the critical care setting. Should recruitment maneuvers be used in the management of ALI and ARDS?Robert M Kacmarek
Respiratory Care Services, Massachusetts General Hospital, and Harvard Medical School, Boston, MA 02114, USA
Respir Care 52:622-31; discussion 631-5. 2007..We explore both sides of the lung recruitment controversy...
- Noninvasive ventilation for treatment of acute respiratory failure in patients undergoing solid organ transplantation: a randomized trialM Antonelli
Istituto di Anestesiologia e Rianimazione, Università Cattolica del Sacro Cuore Rome, Italy
JAMA 283:235-41. 2000..Noninvasive ventilation (NIV) has been associated with lower rates of endotracheal intubation in populations of patients with acute respiratory failure...
- Noninvasive ventilation in immunosuppressed patients with pulmonary infiltrates, fever, and acute respiratory failureG Hilbert
Division of Medical Intensive Care, University Hospital, Bordeaux, France
N Engl J Med 344:481-7. 2001..Avoiding intubation is a major goal in the management of respiratory failure, particularly in immunosuppressed patients. Nevertheless, there are only limited data on the efficacy of noninvasive ventilation in these high-risk patients...
- Noninvasive ventilation in severe hypoxemic respiratory failure: a randomized clinical trialMiquel Ferrer
Unitat de Vigilància Intensiva Respiratòria, Institut Clinic de Pneumologia i Cirurgia Toracica, Universitat de Barcelona, Barcelona, Spain
Am J Respir Crit Care Med 168:1438-44. 2003..39; p=0.017). The use of noninvasive ventilation prevented intubation, reduced the incidence of septic shock, and improved survival in these patients compared with high-concentration oxygen therapy...
- Effects of gas leak on triggering function, humidification, and inspiratory oxygen fraction during noninvasive positive airway pressure ventilationEriko Miyoshi
Intensive Care Unit, Osaka University Hospital, Japan
Chest 128:3691-8. 2005..We evaluated the effects of gas leak on inspiratory trigger function during NPPV with bilevel pressure and ICU ventilators. In addition, we evaluated the effects of gas leak on fraction of inspired oxygen (Fio(2)) and humidification...
- Non-invasive pressure support ventilation versus conventional oxygen therapy in acute cardiogenic pulmonary oedema: a randomised trialJ Masip
Cardiology Department, Consorci Sanitari Creu Roja de Catalunya, Hospital Creu Roja de Barcelona, University of Barcelona, Spain
Lancet 356:2126-32. 2000..We assessed the efficacy of this therapy in acute cardiogenic pulmonary oedema in a randomised comparison with conventional oxygen therapy...
- Right ventricular end-diastolic volume index as a predictor of preload status in patients on positive end-expiratory pressureM L Cheatham
Department of Surgical Education, Orlando Regional Medical Center, FL 32806, USA
Crit Care Med 26:1801-6. 1998....
- ARDSnet ventilatory protocol and alveolar hyperinflation: role of positive end-expiratory pressureSalvatore Grasso
Universita di Bari, Dipartimento dell Emergenza e Trapianti d Organo DETO, Sezione di Anestesiologia e Rianimazione, Ospedale Policlinico, Piazza Giulio Cesare 11, Bari 70124, Italy
Am J Respir Crit Care Med 176:761-7. 2007....
- Recruitment and derecruitment during acute respiratory failure: an experimental studyP Pelosi
Istituto di Anestesia e Rianimazione, , Ospedale Maggiore Policlinico-IRCCS, Milan, Italy
Am J Respir Crit Care Med 164:122-30. 2001..86, p < 0.0001), suggesting that as more tissue is recruited at end-inspiration, more remains recruited at end-expiration. When superimposed pressure exceeded applied airway pressure (Paw), collapse significantly increased...
- Positive end-expiratory pressure at minimal respiratory elastance represents the best compromise between mechanical stress and lung aeration in oleic acid induced lung injuryAlysson Roncally S Carvalho
Biomedical Engineering Program, COPPE, Federal University of Rio de Janeiro, Av, Horácio Macedo, CT Bloco H 327, 2030, 21941 914, Rio de Janeiro, Brazil
Crit Care 11:R86. 2007....
- A chart of failure risk for noninvasive ventilation in patients with COPD exacerbationM Confalonieri
S C Pneumologia, Ospedale di Cattinara, Strada di Fiume, 447, I 34100 Trieste, Italy
Eur Respir J 25:348-55. 2005....
- Which patients with acute exacerbation of chronic obstructive pulmonary disease benefit from noninvasive positive-pressure ventilation? A systematic review of the literatureSean P Keenan
Royal Columbian Hospital, New Westminster, British Columbia V3L 5E7, Canada
Ann Intern Med 138:861-70. 2003..Although several trials have been published on the relative effectiveness of this treatment, apparent inconsistencies in study results remain...
- Clinical review: Positive end-expiratory pressure and cardiac outputThomas Luecke
Department of Anesthesiology and Critical Care Medicine, University Hospital of Mannheim, Germany
Crit Care 9:607-21. 2005..Finally, the hemodynamic consequences of PEEP in patients with heart failure, chronic obstructive pulmonary disease and acute respiratory distress syndrome are discussed...
- Positive end-expiratory pressure after a recruitment maneuver prevents both alveolar collapse and recruitment/derecruitmentJeffrey M Halter
Department of Surgery, State University of New York Upstate Medical University, 750 E Adams Street, Syracuse, NY 13210, USA
Am J Respir Crit Care Med 167:1620-6. 2003..This suggests recruitment followed by inadequate PEEP permits unstable alveoli and may result in ventilator-induced lung injury despite improved oxygenation...
- Recruitment and derecruitment during acute respiratory failure: a clinical studyS Crotti
Istituto di Anestesia e Rianimazione, , Ospedale Maggiore Policlinico-IRCCS, Milan, Italy
Am J Respir Crit Care Med 164:131-40. 2001..When superimposed gravitational pressure exceeded PEEP, end-expiratory collapse increased. We concluded that the rules governing recruitment and derecruitment equally apply in an oleic acid model and in human ALI/ARDS...
- Cardiovascular effects of continuous positive airway pressure in patients with heart failure and obstructive sleep apneaYasuyuki Kaneko
Sleep Research Laboratories, Toronto Rehabilitation Institute, Toronto General Hospital, ON M5G 2C4, Canada
N Engl J Med 348:1233-41. 2003..We hypothesized that treatment of obstructive sleep apnea by continuous positive airway pressure in patients with heart failure would improve left ventricular systolic function...
- Outcome in noninvasively and invasively ventilated hematologic patients with acute respiratory failurePieter O Depuydt
Department of Intensive Care, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium
Chest 126:1299-306. 2004....
- Noninvasive positive-pressure ventilation in patients with milder chronic obstructive pulmonary disease exacerbations: a randomized controlled trialSean P Keenan
Sean P Keenan MD, Suite 103, 250 Keary Street, New Westminster, British Columbia, V3L 5E7, Canada
Respir Care 50:610-6. 2005....
- Positive pressure ventilation in the management of acute and chronic cardiac failure: a systematic review and meta-analysisSunil Nadar
University Department of Medicine, City Hospital, Birmingham B18 7QH, UK
Int J Cardiol 99:171-85. 2005..Many trials are still ongoing and the results of these studies would throw more light on the present role of non-invasive ventilation in the management of CHF...
- Effect of the humidification device on the work of breathing during noninvasive ventilationFrancois Lellouche
Medical Intensive Care Unit, Hopital Henri Mondor, AP HP, Université Paris 12 et INSERM U492, 51 Av du Marechal de Lattre de Tassigny, 94010 Creteil, France
Intensive Care Med 28:1582-9. 2002..This study compared the effect of HH and HME during noninvasive ventilation (NIV) on arterial blood gases and patient's effort assessed by respiratory muscles pressure-time product and by work of breathing (WOB)...
- Electrical impedance tomography: a method for monitoring regional lung aeration and tidal volume distribution?Inez Frerichs
Department of Anaesthesiological Research, Centre of Anaesthesiology, Emergency and Intensive Care Medicine, University of Gottingen, Robert Koch Strasse 40, 37075, Gottingen, Germany
Intensive Care Med 29:2312-6. 2003..To demonstrate the monitoring capacity of modern electrical impedance tomography (EIT) as an indicator of regional lung aeration and tidal volume distribution...
- Noninvasive vs. conventional mechanical ventilation in patients with chronic obstructive pulmonary disease after failure of medical treatment in the ward: a randomized trialG Conti
Universita Cattolica del S Cuore, Policlinico A Gemelli, Largo F Vito, 00168 Rome, Italy
Intensive Care Med 28:1701-7. 2002....
- Acute respiratory failure in patients with severe community-acquired pneumonia. A prospective randomized evaluation of noninvasive ventilationM Confalonieri
Unità Operativa di Pneumologia, Ospedale Civile di Piacenza, Piacenza, Italy
Am J Respir Crit Care Med 160:1585-91. 1999..A 2-mo survival advantage was seen in patients with COPD...
- Myocardial infarction rate in acute pulmonary edema: noninvasive pressure support ventilation versus continuous positive airway pressureAndrea Bellone
Emergency Department, Niguarda Ca Granda Hospital, P za Ospedale, Milano, Italy
Crit Care Med 32:1860-5. 2004..We investigated whether the use of NIPSV increases the incidence of acute myocardial infarction compared with continuous positive airway pressure (CPAP) in patients with acute pulmonary edema...
- Evaluation of an electrical impedance tomography-based Global Inhomogeneity Index for pulmonary ventilation distributionZhanqi Zhao
Section for Experimental Anesthesiology, Department of Anesthesiology and Critical Care Medicine, University Medical Center, Freiburg, Germany
Intensive Care Med 35:1900-6. 2009..To evaluate the plausibility, stability, and interindividual comparability of the global inhomogeneity index (GI) based on electrical impedance tomography (EIT)...
- Reducing atelectasis attenuates bacterial growth and translocation in experimental pneumoniaAnton H van Kaam
Department of Anesthesiology and Laboratory of Pediatrics, Erasmus MC Faculty, Rotterdam, The Netherlands
Am J Respir Crit Care Med 169:1046-53. 2004..These findings suggest that minimizing alveolar collapse by exogenous surfactant and open lung ventilation may reduce the risk of pneumonia and subsequent sepsis in ventilated patients...
- Influence of respiratory rate on gas trapping during low volume ventilation of patients with acute lung injuryJean Christophe Richard
Medical Intensive Care Unit, University Hospital Charles Nicolle, 1 rue de Germont, 76031 Rouen, France
Intensive Care Med 28:1078-83. 2002..The aim of this study was to test whether a high respiratory rate induces significant intrinsic positive end-expiratory pressure (PEEPi) in these patients...
- Mechanical ventilation in acute respiratory failure: recruitment and high positive end-expiratory pressure are necessaryCarmen Silvia Valente Barbas
Division of Pulmonary and Critical Care, University of Sao Paulo, Sao Paulo, Brazil and Intensive Care Unit, Albert Einstein Hospital, Sao Paulo, Brazil
Curr Opin Crit Care 11:18-28. 2005....
- Association of noninvasive ventilation with nosocomial infections and survival in critically ill patientsE Girou
Unité d Hygiène et Prévention de l Infection, Hopital Henri Mondor, 94010 Creteil, France
JAMA 284:2361-7. 2000..Invasive life-support techniques are a major risk factor for nosocomial infection. Noninvasive ventilation (NIV) can be used to avoid endotracheal intubation and may reduce morbidity among patients in intensive care units (ICUs)...
- Leak compensation in positive pressure ventilators: a lung model studyS Mehta
Mt Sinai Hospital, University of Toronto, Canada
Eur Respir J 17:259-67. 2001..Adequate inspiratory flows and durations should be used, triggering sensitivity should be adjusted to prevent autocycling, and a mechanism should be available to limit inspiratory time and avoid I:E ratio inversion...
- Heliox and noninvasive positive-pressure ventilation: a role for heliox in exacerbations of chronic obstructive pulmonary disease?Dean R Hess
Department of Respiratory Care, Massachusetts General Hospital, Boston, MA 02114, USA
Respir Care 51:640-50. 2006..Lacking such evidence, the use of heliox in patients with COPD exacerbation cannot be considered standard therapy...
- Visual validation of the mechanical stabilizing effects of positive end-expiratory pressure at the alveolar levelU G McCann
Department of Surgery, State University of New York Upstate Medical University, 750 East Adams Street, Syracuse, NY 13210. USA
J Surg Res 99:335-42. 2001..The ability of PEEP to stabilize alveoli and reduce shear during mechanical ventilation has important implications for therapeutic strategies directed at VILI and acute respiratory distress syndrome...
- Higher versus lower positive end-expiratory pressures in patients with the acute respiratory distress syndromeRoy G Brower
Johns Hopkins University, Baltimore, USA
N Engl J Med 351:327-36. 2004..We conducted this trial to compare the effects of higher and lower PEEP levels on clinical outcomes in these patients...
- Kinetic and reversibility of mechanical ventilation-associated pulmonary and systemic inflammatory response in patients with acute lung injuryF Stuber
Department of Anesthesiology and Intensive Care Medicine, University of Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
Intensive Care Med 28:834-41. 2002..To investigate the kinetic and reversibility of mechanical ventilation-associated pulmonary and systemic inflammatory response in patients with acute lung injury (ALI)...
- Comparison of noninvasive positive pressure ventilation with standard medical therapy in hypercapnic acute respiratory failureT Celikel
Department of Pulmonary and Critical Care Medicine, Marmara University Hospital, Istanbul, Turkey
Chest 114:1636-42. 1998..To compare the efficacy of standard medical therapy (ST) and noninvasive mechanical ventilation additional to standard medical therapy in hypercapnic acute respiratory failure (HARF)...
- Decreased indicators of lung injury with continuous positive expiratory pressure in preterm lambsAlan H Jobe
Division of Pulmonary Biology, Cincinnati Children s Hospital, Cincinnati, Ohio 45229 3039, USA
Pediatr Res 52:387-92. 2002..05). In this model in preterm lambs CPAP results in lower indicators of acute lung injury than does mechanical ventilation during the first 2 h of life...
- Noninvasive positive pressure ventilation in the acute care setting: where are we?N Ambrosino
Pulmonary and Respiratory Intensive Care Unit, Cardio Thoracic Dept, University Hospital Pisa, Italy
Eur Respir J 31:874-86. 2008..Additionally, the technique must be applied in the appropriate location by a trained team in order to avoid disappointing results...
- The assessment of regional lung mechanics with electrical impedance tomography: a pilot study during recruitment manoeuvresCaroline A Grant
Paediatric Intensive Care Unit, Mater Children s Hospital, South Brisbane, QLD, 4101, Australia
Intensive Care Med 35:166-70. 2009..Respiratory mechanics and regional filling capacity of the lung were measured using EIT pre- and post- recruitment and compared to a control group...
- Pressure-controlled versus volume-controlled ventilation during one-lung ventilation for thoracic surgeryM Carmen Unzueta
Department of Anesthesiology, Hospital de Sant Pau, Barcelona, Spain
Anesth Analg 104:1029-33, tables of contents. 2007..In this study we investigated whether PCV results in improved arterial oxygenation compared with volume-controlled ventilation (VCV) during OLV...
- PEEP titration guided by ventilation homogeneity: a feasibility study using electrical impedance tomographyZhanqi Zhao
Department of Biomedical Engineering, Furtwangen University, Jakob Kienzle Strasse 17, D 78054 Villingen Schwenningen, Germany
Crit Care 14:R8. 2010..The aim of this study was to test the feasibility of PEEP titration guided by ventilation homogeneity using the global inhomogeneity (GI) index based on electrical impedance tomography (EIT) images...
- Adaptive pressure support servo-ventilation: a novel treatment for Cheyne-Stokes respiration in heart failureH Teschler
Faculty of Medicine, Ruhrlandklinik, University of Essen, Essen, Germany
Am J Respir Crit Care Med 164:614-9. 2001..All subjects preferred ASV to CPAP. One night ASV suppresses central sleep apnea and/or CSR (CSA/CSR) in heart failure and improves sleep quality better than CPAP or 2 L/min oxygen...
- Measurement of air trapping, intrinsic positive end-expiratory pressure, and dynamic hyperinflation in mechanically ventilated patientsLluis Blanch
Critical Care Center, Hospital de Sadabell, Institut Universitari Fundació Parc Taulí, Corporacio Parc Tauli, Universitad Autonoma de Barcelona, Sadabell, Spain
Respir Care 50:110-23; discussion 123-4. 2005..Ventilator graphics are invaluable for monitoring and treatment decisions at the bedside...
- Prevention of atelectasis formation during induction of general anesthesiaMarco Rusca
Departments of Anesthesiology, University Hospital, Lausanne, Switzerland
Anesth Analg 97:1835-9. 2003..005). Atelectasis formation is prevented by application of PEEP during the anesthesia induction despite the use of large oxygen concentrations, resulting in improved oxygenation...
- Effects of mechanical ventilation on release of cytokines into systemic circulation in patients with normal pulmonary functionH Wrigge
Department of Anesthesiology and Intensive Care Medicine, University of Bonn, Germany
Anesthesiology 93:1413-7. 2000....
- Non-invasive pressure support ventilation in severe community-acquired pneumoniaP Jolliet
Medical Intensive Care Division, University Hospital, Geneva, Switzerland
Intensive Care Med 27:812-21. 2001....
- Predicting the result of noninvasive ventilation in severe acute exacerbations of patients with chronic airflow limitationA Anton
Department of Respiratory Medicine, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Barcelona, Spain
Chest 117:828-33. 2000....
- Cardiovascular issues in respiratory careMichael R Pinsky
Bioengineering and Anesthesiology, Department of Critical Care Medicine, University of Pittsburgh Medical Center, 606 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA 15213, USA
Chest 128:592S-597S. 2005..In patients with hypervolemic heart failure, this afterload reducing effect can result in improved LV ejection, increased cardiac output, and reduced myocardial oxygen demand...
- Effect of mechanical ventilation on inflammatory mediators in patients with acute respiratory distress syndrome: a randomized controlled trialV M Ranieri
Istituto di Anestesiologia e Rianimazione, Universita di Bari, Ospedale Policlinico, Italy
JAMA 282:54-61. 1999....
- Mechanical ventilation guided by esophageal pressure in acute lung injuryDaniel Talmor
Department of Anesthesia, Critical Care, and Pain Medicine, Beth Israel Deaconess Medical Center, Boston 02215, USA
N Engl J Med 359:2095-104. 2008....
- Lung protective ventilatory strategies in very low birth weight infantsR Ramanathan
Division of Neonatal Medicine, Department of Pediatrics, Women s and Children s Hospital and Childrens Hospital Los Angeles, Keck School of Medicine University of Southern California, Los Angeles, CA, USA
J Perinatol 28:S41-6. 2008..Initial steps in the management of preterm infants may also include sustained inflation to establish functional residual capacity, followed by noninvasive ventilation to minimize lung injury and subsequent development of BPD...
- Helium-oxygen versus air-oxygen noninvasive pressure support in decompensated chronic obstructive disease: A prospective, multicenter studyPhilippe Jolliet
Medical Intensive Care Division, University Hospital, Geneva, Switzerland
Crit Care Med 31:878-84. 2003....
- Optimal oxygen concentration during induction of general anesthesiaLennart Edmark
Department of Anesthesiology and Intensive Care, Central Hospital, Vasteras, and Research Associate, Department of Medical Sciences, Clinical Physiology, University Hospital, Uppsala, Sweden
Anesthesiology 98:28-33. 2003..The use of 100% oxygen during induction of anesthesia may produce atelectasis. The authors investigated how different oxygen concentrations affect the formation of atelectasis and the fall in arterial oxygen saturation during apnea...
- Alveolar recruitment in combination with sufficient positive end-expiratory pressure increases oxygenation and lung aeration in patients with severe chest traumaDierk Schreiter
Surgical Intensive Care Unit, Department of Surgery, University Hospital Leipzig, Leipzig, Germany
Crit Care Med 32:968-75. 2004..Investigation of oxygenation and lung aeration during mechanical ventilation according to the open lung concept in patients with acute lung injury or acute respiratory distress syndrome...
- The effect of non-invasive positive pressure ventilation (NIPPV) on cognitive function in amyotrophic lateral sclerosis (ALS): a prospective studyI C Newsom-Davis
Department of Psychology, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK
J Neurol Neurosurg Psychiatry 71:482-7. 2001..These deficits may be partially improved by NIPPV over a 6 week period. This has important implications for investigations of both cognitive dysfunction in non-demented patients with ALS, and the effect of ventilation on quality of life...
- A decremental PEEP trial identifies the PEEP level that maintains oxygenation after lung recruitmentKarim Girgis
Surgical Intensive Care Unit, New Kasr El Aini Teaching Hospital and Cairo University, Cairo, Egypt
Respir Care 51:1132-9. 2006..To assess the ability of a decremental trial of positive end-expiratory pressure (PEEP) to identify an optimal PEEP level that maintains oxygenation after a lung-recruitment maneuver...
- Sigh in supine and prone position during acute respiratory distress syndromePaolo Pelosi
Dipartimento di Scienze Cliniche e Biologiche, Universita degli Studi dell Insubria, Ospedale di Circolo, Fondazione Macchi, Varese
Am J Respir Crit Care Med 167:521-7. 2003..82, p < 0.001). We conclude that adding a recruitment maneuver such as cyclical sighs during ventilation in the prone position may provide optimal lung recruitment in the early stage of ARDS...
- Impact of ventilation parameters and duration of ventilator use on non-invasive home ventilation in restrictive thoracic disordersStephan Budweiser
Centre of Pneumology, Hospital Donaustauf, Donaustauf, Germany
Respiration 73:488-94. 2006..Non-invasive positive pressure ventilation (NPPV) is an accepted treatment option for chronic ventilatory failure due to restrictive thoracic disorders...
- Effectiveness and side effects of closed and open suctioning: an experimental evaluationSophie Lindgren
Department of Anaesthesia and Intensive Care, Sahlgrenska University Hospital, 413 45 Gothenburg, Sweden
Intensive Care Med 30:1630-7. 2004....
- Dynamic mechanical consequences of deep inflation in mice depend on type and degree of lung injuryGilman Allen
Department of Medicine, Vermont Lung Center, University of Vermont, Bulington, Vermont 05405 0075, USA
J Appl Physiol (1985) 96:293-300. 2004..001). We conclude that the effects of DIs in acute lung injury depend on the degree of lung injury but only to the extent that this injury reflects a disruption of the air-liquid interface...
- The evidence for noninvasive positive-pressure ventilation in the care of patients in acute respiratory failure: a systematic review of the literatureDean R Hess
Department of Respiratory Care, Massachusetts General Hospital, Boston MA 02114, USA
Respir Care 49:810-29. 2004..Inhaled bronchodilators can be administered during NPPV, and NPPV can be delivered with helium-oxygen mixture. Institution-specific practice guidelines may be useful to improve NPPV success...
- A pilot prospective, randomized, placebo-controlled trial of bilevel positive airway pressure in acute asthmatic attackArie Soroksky
Pulmonary Institute, Assaf Harofeh Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Israel
Chest 123:1018-25. 2003....
- Positive end-expiratory pressure in acute respiratory distress syndrome: should the 'open lung strategy' be replaced by a 'protective lung strategy'?Jean Jacques Rouby
Réanimation Chirurgicale Polyvalente Pierre Viars, Groupe Hospitalier Pitie Salpetriere, Assistance Publique Hopitaux de Paris, Université Pierre et Marie Curie of Paris 6, 47 83 boulevard de l Hopital, Paris Cedex 13, France
Crit Care 11:180. 2007..The best positive end-expiratory pressure should correspond to the best compromise between recruitment and distension, a condition that coincides with the best respiratory elastance...
- Effects of cyclic opening and closing at low- and high-volume ventilation on bronchoalveolar lavage cytokinesEric K Chu
Department of Medicine and Critical Care Medicine, St Michael s Hospital, University of Toronto, Ontario, Canada
Crit Care Med 32:168-74. 2004..To examine the mechanisms of ventilator-induced lung injury at low and high lung volumes...
- Ventilation strategy using low tidal volumes, recruitment maneuvers, and high positive end-expiratory pressure for acute lung injury and acute respiratory distress syndrome: a randomized controlled trialMaureen O Meade
Department of Medicine, McMaster University, Hamilton, Ontario, Canada
JAMA 299:637-45. 2008..Low-tidal-volume ventilation reduces mortality in critically ill patients with acute lung injury and acute respiratory distress syndrome. Instituting additional strategies to open collapsed lung tissue may further reduce mortality...
- Low tidal volume reduces epithelial and endothelial injury in acid-injured rat lungsJames A Frank
Cardiovascular Research Institute and the Department of Medicine, University of California, San Francisco, San Francisco, California 94143 0130, USA
Am J Respir Crit Care Med 165:242-9. 2002..The additional decrease in pulmonary edema with a tidal volume of 3 ml/kg is partly accounted for by greater protection of the alveolar epithelium...
- Lower inflection point and recruitment with PEEP in ventilated patients with acute respiratory failureM Mergoni
Servizio di Anestesia e Rianimazione, Azienda Ospedaliera di Parma, 43100 Parma, Italy
J Appl Physiol (1985) 91:441-50. 2001..A RV was found even when a LIP was not present. We conclude that the recruitment phenomenon is not closely related to the presence of a LIP and that a simple method can be used to measure RV...
- Elastic properties of the lung and the chest wall in young and adult healthy pigsE De Robertis
Dept of Clinical Physiology, University Hospital of Lund, Sweden
Eur Respir J 17:703-11. 2001..A strong tendency to lung collapse contributes to a complex pattern of elastic pressure/volume curves. At low volumes and distending pressures the chest wall contributes significantly to changes in respiratory system elastance...
- Positive end-expiratory pressure titration in acute respiratory distress syndrome patients: impact on right ventricular outflow impedance evaluated by pulmonary artery Doppler flow velocity measurementsJ M Schmitt
Medical Intensive Care Unit, , , Boulogne, France
Crit Care Med 29:1154-8. 2001..Application of PEEPA worsened RV systolic function impairment produced by tidal ventilation. Conversely, application of PEEPS reduced RV systolic function impairment, suggesting an association with a lower pulmonary vascular resistance...
- A meta-analysis of noninvasive weaning to facilitate liberation from mechanical ventilationKaren E A Burns
Division of Critical Care Medicine, London Health Sciences Centre Victoria Hospital
Can J Anaesth 53:305-15. 2006....
- Short-term effects of expiration under positive pressure in patients with acute exacerbation of chronic obstructive pulmonary disease and mild acidosis requiring non-invasive positive pressure ventilationAndrea Bellone
Respiratory Intensive Care Unit, San Sebastiano Hospital, Emilia, Italy
Intensive Care Med 28:581-5. 2002....
- High-frequency oscillatory ventilation: effects on lung function, mechanics, and airway cytokines in the immature baboon model for neonatal chronic lung diseaseB A Yoder
Southwest Foundation for Biomedical Research, San Antonio, Texas, USA
Am J Respir Crit Care Med 162:1867-76. 2000..Though enhanced alveolization was not observed, HFOV for 1 to 2 mo resulted in consistently more uniform lung inflation than LV-PPV...
- Influence of positive airway pressure on the pressure gradient for venous return in humansH Jellinek
Department of Anesthesiology and Intensive Care Medicine, Community Hospital of Lainz, A 1130 Vienna, Austria
J Appl Physiol (1985) 88:926-32. 2000..In conclusion, we demonstrated that positive Paw equally increases Pra and Pms in humans and alters venous return without changes in the pressure gradient (Pms - Pra)...
- Positive end-expiratory pressure setting in adults with acute lung injury and acute respiratory distress syndrome: a randomized controlled trialAlain Mercat
Département de Réanimation Médicale et Médecine Hyperbare, CHU d Angers, Angers, France
JAMA 299:646-55. 2008..The need for lung protection is universally accepted, but the optimal level of positive end-expiratory pressure (PEEP) in patients with acute lung injury (ALI) or acute respiratory distress syndrome remains debated...
- Survey of non-invasive ventilation (NIPPV) in patients with acute exacerbations of chronic obstructive pulmonary disease (COPD) in the UKM J Doherty
Medical Chest Unit, Castle Hill Hospital, Cottingham, East Yorkshire, UK
Thorax 53:863-6. 1998..In those in which it is available it is generally underused. Lack of training and problems with funding are generally given for the failure to introduce NIPPV...
- Noninvasive proportional assist ventilation for acute respiratory insufficiency. Comparison with pressure support ventilationP C Gay
Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, Minnesota, USA
Am J Respir Crit Care Med 164:1606-11. 2001..Compared with PSV delivered with the Puritan-Bennett 7200ae, PAV is associated with more rapid improvements in some physiologic variables and is better tolerated...
- Pulmonary gas distribution during ventilation with different inspiratory flow patterns in experimental lung injury -- a computed tomography studyH Roth
Department of Anesthesiology and Critical Care, University Hospital of Mannheim, Faculty of Clinical Medicine, University of Heidelberg, Heidelberg, Germany
Acta Anaesthesiol Scand 48:851-61. 2004....
- Effects of non-invasive ventilation on survival and quality of life in patients with amyotrophic lateral sclerosis: a randomised controlled trialStephen C Bourke
Department of Respiratory Medicine, University of Newcastle upon Tyne and the Newcastle Hospitals Trust, Newcastle upon Tyne, UK
Lancet Neurol 5:140-7. 2006..We aimed to assess the effect of NIV on quality of life and survival in amyotrophic lateral sclerosis in a randomised controlled trial...
- Objective measures of the efficacy of noninvasive positive-pressure ventilation in amyotrophic lateral sclerosisL S Aboussouan
Division of Pulmonary and Critical Care Medicine, Wayne State University School of Medicine, Harper Hospital, 3 Hudson, 3990 John R, Detroit, Michigan 48201, USA
Muscle Nerve 24:403-9. 2001..002). Although NIPPV has no impact on the rate of decline of lung function and may have deleterious effects on spirometric measures, it may improve quality of life and survival...
- Determinants of Fi,O2 with oxygen supplementation during noninvasive two-level positive pressure ventilationF Thys
Emergency Dept, Cliniques Universitaires Saint Luc, Universite Catholique de Louvain, Brussels, Belgium
Eur Respir J 19:653-7. 2002..If inspiratory airway pressure levels are >12 cmH2O, oxygen flows should be at least 4 L x min(-1)...
- Effect of positive pressure on venous return in volume-loaded cardiac surgical patientsPaul C M van den Berg
Department of Intensive Care, Leiden University Medical Centre, 2300 RC Leiden, The Netherlands
J Appl Physiol (1985) 92:1223-31. 2002....
- A prospective, randomized trial of BiPAP in severe acute congestive heart failureM A Levitt
Department of Emergency Medicine, Alameda County Medical Center-Highland Campus, Oakland, California, USA
J Emerg Med 21:363-9. 2001..An increase in AMI rate with BiPAP was not found in this study as previously reported. This study provides support for a larger clinical trial assessing the safety and efficacy of BiPAP in acute CHF...
- Lung recruitment during small tidal volume ventilation allows minimal positive end-expiratory pressure without augmenting lung injuryP C Rimensberger
Department of Critical Care, The Hospital for Sick Children, University of Toronto, Ontario, Canada
Crit Care Med 27:1940-5. 1999....
- Noninvasive positive pressure ventilation: five years of experience in a pediatric intensive care unitSandrine Essouri
Pediatric Intensive Care Unit, Kremlin Bicetre Hospital, Assistance Publique Hopitaux de Paris, Kremlin Bicetre, France
Pediatr Crit Care Med 7:329-34. 2006..To evaluate the feasibility and outcome of noninvasive positive pressure ventilation (NPPV) in daily clinical practice...
- Effects of training with heliox and noninvasive positive pressure ventilation on exercise ability in patients with severe COPDJames E Johnson
Cardiopulmonary Rehabilitation, University of Alabama at Birmingham, Birmingham, AL, USA
Chest 122:464-72. 2002....
- Supramaximal inflation improves lung compliance in subjects with amyotrophic lateral sclerosisNoah Lechtzin
Department of Internal Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Chest 129:1322-9. 2006..Noninvasive positive-pressure ventilation (NPPV) prolongs survival in ALS patients but may also have additional beneficial effects...
- Pattern of lung emptying and expiratory resistance in mechanically ventilated patients with chronic obstructive pulmonary diseaseEumorfia Kondili
Department of Intensive Care Medicine, University Hospital of Heraklion, University of Crete, 711 10 Heraklion, Crete, Greece
Intensive Care Med 30:1311-8. 2004..To study the pattern of lung emptying and expiratory resistance in mechanically ventilated patients with chronic obstructive pulmonary disease (COPD)...
- Esophageal and transpulmonary pressures in acute respiratory failureDaniel Talmor
Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA, USA
Crit Care Med 34:1389-94. 2006..By measuring esophageal pressure (Pes), we sought to characterize influence of the chest wall on Ppl and transpulmonary pressure (PL) in patients with acute respiratory failure...
- Pressure-volume curve does not predict steady-state lung volume in canine lavage lung injuryJohn M Downie
Department of Anesthesiology and Critical Care Medicine, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
Am J Respir Crit Care Med 169:957-62. 2004..These results support the interpretation of Pflex as pressure threshold for recruitment, but otherwise do not suggest a role for the pressure-volume curve in predicting steady-state lung volume...
- Influence of low tidal volumes on gas exchange in acute respiratory distress syndrome and the role of recruitment maneuversJay A Johannigman
Department of Surgery, University of Cincinnati, Ohio 45267 0558, USA
J Trauma 54:320-5. 2003..BACKGROUND Use of a low tidal volume (V(T)) strategy in the treatment of acute respiratory distress syndrome can lead to a decrease in oxygenation. This study evaluated the safety and efficacy of a recruitment maneuver (RM) in this setting...
- A comparison of biologically variable ventilation to recruitment manoeuvres in a porcine model of acute lung injuryDuane J Funk
Department of Anaesthesia, University of Manitoba, Winnipeg, Manitoba, Canada
Respir Res 5:22. 2004....
- Noninvasive ventilation in cardiogenic pulmonary edema: a multicenter randomized trialStefano Nava
Respiratory Intensive Care Unit, Istituto Scientifico di Pavia, Fondazione S Maugeri, 27100 Pavia, Italy
Am J Respir Crit Care Med 168:1432-7. 2003..Noninvasive pressure support ventilation does, however, reduce the intubation rate in the subgroup of hypercapnic patients...
- Lower tidal volume ventilation and plasma cytokine markers of inflammation in patients with acute lung injuryPolly E Parsons
Division of Pulmonary and Critical Care Medicine, Department of Medicine, Fletcher Allen Health Care, University of Vermont, USA
Crit Care Med 33:1-6; discussion 230-2. 2005....
- GI complications in patients receiving mechanical ventilationG M Mutlu
Section of Respiratory and Critical Care Medicine, University of Illinois at Chicago, Chicago, IL, USA
Chest 119:1222-41. 2001..Incorporated in this review are discussions of the most prevalent GI complications associated with MV, and current diagnosis and management of these problems...
- Positive end-expiratory pressure modulates local and systemic inflammatory responses in a sepsis-induced lung injury modelMaria Teresa Herrera
Research Institute, Hospital Universitario N S de Candelaria, Carretera del Rosario s n, 38010, Santa Cruz de Tenerife, Canary Islands, Spain
Intensive Care Med 29:1345-53. 2003..We examined the effects of positive end-expiratory pressure (PEEP) in the setting of a clinically relevant, in vivo animal model of sepsis-induced acute lung injury ventilated with low or injurious tidal volume...
- Systematic review of noninvasive positive pressure ventilation in severe stable COPDM A Kolodziej
Dept of Pulmonary Medicine, Faculty of Medicine and Dentistry, University of Alberta Hospitals, University of Alberta, Edmonton, AB, Canada
Eur Respir J 30:293-306. 2007....
- High tidal volume and positive fluid balance are associated with worse outcome in acute lung injuryYasser Sakr
Department of Intensive Care, Erasme Hospital, University of Brussels, Belgium
Chest 128:3098-108. 2005..We tested the hypothesis that infection/sepsis and use of higher tidal volumes than those applied in the ARDS Network (ARDSnet) study (> 7.4 mL/kg of predicted body weight) would worsen outcome in patients with ALI/ARDS...
- Lung recruitment in patients with the acute respiratory distress syndromeLuciano Gattinoni
Istituto di Anestesiologia e Rianimazione, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico, Ospedale Maggiore Policlinico, Mangiagalli, Regina Elena di Milano, Universita degli Studi di Milano, Milan, Italy
N Engl J Med 354:1775-86. 2006....
- Effects of recruitment maneuvers in patients with acute lung injury and acute respiratory distress syndrome ventilated with high positive end-expiratory pressureRoy G Brower
Crit Care Med 31:2592-7. 2003..Beneficial effects on gas exchange in responders appear to be of brief duration. More information is needed to determine the role of recruitment maneuvers in the management of ALI/ARDS...
- Predictors of failure of noninvasive positive pressure ventilation in patients with acute hypoxemic respiratory failure: a multi-center studyM Antonelli
Istituto di Anestesiologia e Rianimazione, Universita Cattolica del Sacro Cuore, Policlinico A Gemelli, Largo A Gemelli 8, 00168 Rome, Italy
Intensive Care Med 27:1718-28. 2001..In these patients, predictors of NPPV failure are not well characterized...
- Safety and efficacy of a sustained inflation for alveolar recruitment in adults with respiratory failureS E Lapinsky
Department of Medicine, Mount Sinai Hospital, Ontario, Canada
Intensive Care Med 25:1297-301. 1999..To assess the safety and efficacy of a sustained inflation, used as a lung volume recruitment maneuver in ventilated patients with hypoxemic respiratory failure...
- Respiratory effects of different recruitment maneuvers in acute respiratory distress syndromeJean Michel Constantin
General Intensive Care Unit, Hotel Dieu Hospital, University Hospital of Clermont Ferrand, Boulevard L, Malfreyt, 63058 Clermond Ferrand, France
Crit Care 12:R50. 2008..Alveolar derecruitment may occur during low tidal volume ventilation and may be prevented by recruitment maneuvers (RMs). The aim of this study was to compare two RMs in acute respiratory distress syndrome (ARDS) patients...
- Stretch and Hyperoxia in Ventilator-induced Lung InjuryScott E Sinclair; Fiscal Year: 2010....
- Critical Role of Alveolar Fibrin in Acute Lung InjuryGilman Allen; Fiscal Year: 2008..abstract_text> ..
- Respiratory Control Stability in Obstructive Sleep ApneaDavid Wellman; Fiscal Year: 2004..b. High LG, independent of upper airway collapsibility, is associated with more severe (more frequently apneas) OSA. c. Lower LG will reduce OSA severity in patients with high LG. ..
- Pathogenesis and Genetics of Obstructive Sleep ApneaRichard Schwab; Fiscal Year: 2006..To address these specific aims, we have planned a logical series of studies that will provide insight in the pathogenesis of obstructive sleep apnea and the anatomic risk factors for this condition. ..
- Aging Influence on the Development of Sleep ApneaAtul Malhotra; Fiscal Year: 2007..abstract_text> ..
- Sleep Apnea and Obesity: Cardiovascular Risk AssessmentAtul Malhotra; Fiscal Year: 2008..This data may have important implications for the diagnosis and treatment of these abnormalities. ..
- ECG-derived estimators of sleep physiologyRobert Thomas; Fiscal Year: 2006..3) To correlate the biomarker with excessive daytime sleepiness, subjective sleep quality and cardiovascular morbidity (SHHS), and reduced neurocognitive function (NAPS). ..
- WORKING MEMORY IN OBSTRUCTIVE SLEEP APNEA-AN fMRI STUDYRobert Thomas; Fiscal Year: 2006..abstract_text> ..
- Noninvasive Ventilation in Children with Cystic FibrosisCAROLE MARCUS; Fiscal Year: 2004..In keeping with the mission of the RFA, this study will use a multidisciplinary approach to improve management and enhance the quality of life in children with chronic respiratory failure. ..
- Ventilator-Induced Lung Injury:Mechanisms & ConsequencesScott Sinclair; Fiscal Year: 2005..Aim 3A: Document cyclical airway collapse and reopening via changes in regional ventilation distribution. Aim 3B: Validate a method to estimate appropriate PEEP level to prevent cyclical airway collapse. ..
- PATHOPHYSIOLOGY OF CHILDHOOD OBSTRUCTIVE SLEEP APNEACAROLE MARCUS; Fiscal Year: 2008..These studies will help elucidate the pathophysiology of OSAS in obese adolescents, ultimately resulting in improved management of this disease. ..
- Family Linkage Study of Obstructive Sleep ApneaAllan Pack; Fiscal Year: 2007..abstract_text> ..
- Quantifying Left Ventricular Ejection EffectivenessMichael Pinsky; Fiscal Year: 2007..The ultimate goal of this proposal is to develop and validate an echocardiographic-based algorithm that quantifies LV ejection effectiveness by merging both power and synchrony of contraction into a common metric. ..
- RURAL DWELLING OLDER ADULTS: CPAP ADHERENCE SUPPORTCarol Smith; Fiscal Year: 2004..abstract_text> ..
- Sleep Apnea and Hypertension: Role of SNSJoel Dimsdale; Fiscal Year: 2008....
- Sleep-Health & Knowledge in U.S. HispanicsJOSE LOREDO; Fiscal Year: 2009..S. Mexican-American Hispanics should include intensive focus on Sleep Health and Sleep Health knowledge deficits. Key Words: Sleep disorders;Minority health;Epidemiology. ..
- Clinical Trials of FTI RadiosensitizationStephen Hahn; Fiscal Year: 2005..Specific molecular markers that are associated with activation of the Ras signaling pathway will be measured in NSCLC tumor biopsy specimens and will be related to the clinical efficacy of R115777 and radiotherapy. ..
- TREATMENT OF SLEEP APNEA IN THE ELDERLYAllan Pack; Fiscal Year: 2003..These data will give novel definitive information both about identification and treatment of sleep apnea in the elderly. ..
- STRESS, BLOOD PRESSURE AND ETHNICITYJoel E Dimsdale; Fiscal Year: 2010..The study scrutinizes sleep, inflammation, vasodilation, autonomic functioning, and baroreflex regulation. We hypothesize that adversity has a stronger impact on cardiovascular pathophysiology than does ethnicity. ..
- Sleep/Wake Contiuum in Lewy Body DiseaseDonald L Bliwise; Fiscal Year: 2010..The proposed work will also provide important clinical insights into disease correlates and disease course across the broad spectrum of Parkinsonism. ..
- Integrative Models of Neural Adaptive ControlChi Sang Poon; Fiscal Year: 2007..unreadable] [unreadable]..
- SYNAPTIC MECHANISMS IN RESPIRATORY CONTROLChi Sang Poon; Fiscal Year: 2002..Five specific aims are proposed to investigate these mechanisms. The results obtained will provide valuable insights into the mechanisms of afferent signal integration in the NTS and the corresponding effects on respiratory control. ..
- EFFECTS OF STATINS ON PULMONARY HYPERTENSIONReda Girgis; Fiscal Year: 2007..This award will allow the candidate to develop into a well-trained independent researcher in PH. ..
- Xth Oxford Conference on Modeling and Control of BreathingChi Sang Poon; Fiscal Year: 2006..unreadable] [unreadable] [unreadable] [unreadable]..
- DETERMINANTS OF EXACERBATION FREQUENCY IN PATIENTS WITH*Jadwiga Wedzicha; Fiscal Year: 2007..abstract_text> ..
- PREDOCTORAL TRAINING PROGRAM IN NEUROSCIENCERALPH FREGOSI; Fiscal Year: 2008..Facilities for research training include the extensive equipment and expertise in individual faculty laboratories, as well as comprehensive shared resources at the University of Arizona. ..
- TWO NOVEL CPLA2 BINDING PROTEINS AND CELL DEATHJOSEPH VINCENT BONVENTRE; Fiscal Year: 2010..Given the large number of patients that are initiated on dialysis each year, this addresses a critical public health problem. ..
- Nonlinear Analysis of Heart Rate VariabilityChi Sang Poon; Fiscal Year: 2009..These clinical and modeling studies in turn will showcase the proposed analytical techniques thereby paving the way for their application to other complex biomedical modeling and analysis problems in general. ..
- RESPIRATORY RELATED MOTOR OUTPUT TO UPPER AIRWAY MUSLCESSAMUEL KUNA; Fiscal Year: 2003..This work is an expansion of work conducted to date by the PI, who has recently relocated to the University of Pennsylvania. ..
- Effects of sex and fat distribution on sleep disordered breathingPhilip L Smith; Fiscal Year: 2010..The studies also provide insights into the neurohumoral regulation of upper airway function. ..
- Pontomedullary Integration of Respiratory AfferentsChi Sang Poon; Fiscal Year: 2010....
- Angiogenesis in the LungElizabeth Wagner; Fiscal Year: 2010..In an animal model of chronic pulmonary thromboembolic disease, this project will determine the inflammatory cytokines and cells responsible for new vessel growth, and pharmacological and interventional inhibitors. ..
- Improving Respiratory Outcomes in ALSNoah Lechtzin; Fiscal Year: 2006..Lechtzin the opportunity to expand the skills required for development into an independent clinical investigator. ..
- Impact of CPAP on Functional Outcomes in Milder OSATerri Weaver; Fiscal Year: 2006..Secondary aims of the study are: 1) to examine whether CPAP also improves daytime sleepiness; 2) to determine whether CPAP can reduce nocturnal blood pressure to lower the risk for stroke and hypertension linked to OSA. ..
- AIRWAY PARTICLE CLEARANCE--ROLE OF BRONCHIAL CIRCULATIONElizabeth Wagner; Fiscal Year: 2001..Furthermore, the results will contribute to an understanding of the factors that both limit and enhance uptake and distribution of aerosols. ..
- NEUROMUSCULAR CONTROL OF THE PHARYNGEAL AIRWAYRALPH FREGOSI; Fiscal Year: 2002..These experiments will lay the foundation for new and improved treatment strategies for persons with obstructive sleep apnea or with other conditions that are caused by malfunction of the tongue motor system. ..
- SUNDOWN SYNDROME IN A SKILLED NURSING FACILITYDonald Bliwise; Fiscal Year: 2002..These results will provide information on the mechanistic basis for sundowning in aged patients with dementing disorders. ..
- METALLOPROTEINASES IN VENTILATOR-INDUCED LUNG INJURYHussein Foda; Fiscal Year: 2003..By better understanding the mechanisms that lead to ventilator-induced lung injury, therapeutic strategies may be devised to improve the outcome in this highly fatal condition. ..
- CHEMORECEPTORS AND HYPERTENSION AND SLEEP APNEAJOSE LOREDO; Fiscal Year: 2003..This training will provide the basis of an MPH degree and a solid theoretical background for future conduct of quality clinical research. ..
- FACILITATION OF EPILEPTIC ACTIVITY BY SLEEP AND AROUSALBeth Malow; Fiscal Year: 2003..abstract_text> ..
- MODULATION OF OXIDANT INJURY BY FGF-10Daya Upadhyay; Fiscal Year: 2003..My proposed work will enable me to understand the molecular and biological basis of the pathophysiology of acute respiratory distress syndrome and pulmonary fibrosis. ..
- Effects of Treating Obstructive Sleep Apnea in EpilepsyBeth Malow; Fiscal Year: 2004..Develop quality control measures to ensure accurate and consistent data collection among sites in the RCT, including aspects related to remote data entry and standardization of performance and interpretation of PSG studies across sites...
- VENTILATOR-ASSOCIATED ALVEOLAR EPITHELIAL INJURYJames Frank; Fiscal Year: 2006..This research and comprehensive career development plan will prepare me to become an independent investigator in the mechanisms of alveolar epithelial injury and ventilator-associated lung injury. ..
- Neuromorphic Electronic Model of Synaptic PlasticityChi Sang Poon; Fiscal Year: 2006..unreadable] [unreadable]..
- Pulmonary delivery of nicotine using the AERx SystemStephen Farr; Fiscal Year: 2005..The long-term goal of this proposed project is to develop an inhalation product (the AERx-nicotine) as a therapy for smoking cessation. ..
- Molecular Targets for Drug and Radiation SensitivityStephen Hahn; Fiscal Year: 2007..abstract_text> ..
- Melatonin for Sleep in Children with Autism: Safety, Tolerability, and DosingBeth Malow; Fiscal Year: 2009..We will determine the response of melatonin dose on sleep latency using polysomnography and actigraphy, a validated and non-intrusive measure of sleep onset and duration. Adverse events will also be captured. ..
- PHARYNGEAL AIRWAY FUNCTIONSAMUEL KUNA; Fiscal Year: 2003....
- MICROARRAY EXPRESSION PROFILING OF RODENT MODELS OF HUMAAllan Pack; Fiscal Year: 2003..abstract_text> ..
- Biomarkers of Aging in the Bay Area Sleep CohortDonald Bliwise; Fiscal Year: 2005..abstract_text> ..
- MECHANICS OF ACUTE LUNG INJURYJason Bates; Fiscal Year: 2009..The results of our studies are expected to lead to the design of physiologically-based lung recruitment strategies that can be tailored to the individual patient with ALI. This will set the stage for future clinical trials. ..
- EVALUATION OF DIAGNOSTIC TESTS FOR PEDIATRIC SLEEP APNEACarol Rosen; Fiscal Year: 2004..abstract_text> ..
- Effect of leukoreduction on infection risk in traumaAvery Nathens; Fiscal Year: 2004..abstract_text> ..
- Effects of Opioids on Sleep and FatigueJoel Dimsdale; Fiscal Year: 2004..abstract_text> ..
- Research Priorities in Ambulatory Management of Obstructive Sleep Apnea WorkshopSAMUEL KUNA; Fiscal Year: 2007..We submit that this workshop is an essential ?next step? to ensuring that there is[unreadable] substantive advancement of scientific knowledge in this important field. ..
- Polysomnographic Assessment of Alternative TreatmentDonald Bliwise; Fiscal Year: 2006..abstract_text> ..
- Fetal Adaptation of Chronic Uterine Blood Flow ReductionDavid Boyle; Fiscal Year: 2006..These data will be crucial in the design of potential interventions in humans to prevent and/or mitigate fetal growth restriction and its lifelong consequences. ..
- Technological Home Care: Improving CaregivingCarol Smith; Fiscal Year: 2009..The potential significance and the long term goals are to strengthen home caregiving skills, improve health status, quality of life and self-management of chronic illness symptoms and invasive home care treatment. ..
- The Electrophysiology of Motor Neuron DiseasesMark Bromberg; Fiscal Year: 2002..Currently, most MUNE techniques rely on proprietary software. We will develop software for use on PC-based computer systems, making them available to all laboratories. ..
- Subcortical Hyperintensities in Sleep Apnea SyndromeMark Aloia; Fiscal Year: 2007..We expect to analyze data on approximately 1,120 participants based on our preliminary studies with this data set. [unreadable] [unreadable]..