positive pressure respiration

Summary

Summary: A method of mechanical ventilation in which pressure is maintained to increase the volume of gas remaining in the lungs at the end of expiration, thus reducing the shunting of blood through the lungs and improving gas exchange.

Top Publications

  1. ncbi Respiratory controversies in the critical care setting. Should recruitment maneuvers be used in the management of ALI and ARDS?
    Robert M Kacmarek
    Respiratory Care Services, Massachusetts General Hospital, and Harvard Medical School, Boston, MA 02114, USA
    Respir Care 52:622-31; discussion 631-5. 2007
  2. ncbi Noninvasive ventilation for treatment of acute respiratory failure in patients undergoing solid organ transplantation: a randomized trial
    M Antonelli
    Istituto di Anestesiologia e Rianimazione, Università Cattolica del Sacro Cuore Rome, Italy
    JAMA 283:235-41. 2000
  3. ncbi Noninvasive ventilation in immunosuppressed patients with pulmonary infiltrates, fever, and acute respiratory failure
    G Hilbert
    Division of Medical Intensive Care, University Hospital, Bordeaux, France
    N Engl J Med 344:481-7. 2001
  4. ncbi Noninvasive ventilation in severe hypoxemic respiratory failure: a randomized clinical trial
    Miquel Ferrer
    Unitat de Vigilància Intensiva Respiratòria, Institut Clinic de Pneumologia i Cirurgia Toracica, Universitat de Barcelona, Barcelona, Spain
    Am J Respir Crit Care Med 168:1438-44. 2003
  5. ncbi Effects of gas leak on triggering function, humidification, and inspiratory oxygen fraction during noninvasive positive airway pressure ventilation
    Eriko Miyoshi
    Intensive Care Unit, Osaka University Hospital, Japan
    Chest 128:3691-8. 2005
  6. ncbi Non-invasive pressure support ventilation versus conventional oxygen therapy in acute cardiogenic pulmonary oedema: a randomised trial
    J Masip
    Cardiology Department, Consorci Sanitari Creu Roja de Catalunya, Hospital Creu Roja de Barcelona, University of Barcelona, Spain
    Lancet 356:2126-32. 2000
  7. ncbi Right ventricular end-diastolic volume index as a predictor of preload status in patients on positive end-expiratory pressure
    M L Cheatham
    Department of Surgical Education, Orlando Regional Medical Center, FL 32806, USA
    Crit Care Med 26:1801-6. 1998
  8. ncbi ARDSnet ventilatory protocol and alveolar hyperinflation: role of positive end-expiratory pressure
    Salvatore Grasso
    Universita di Bari, Dipartimento dell Emergenza e Trapianti d Organo DETO, Sezione di Anestesiologia e Rianimazione, Ospedale Policlinico, Piazza Giulio Cesare 11, Bari 70124, Italy
    Am J Respir Crit Care Med 176:761-7. 2007
  9. ncbi Recruitment and derecruitment during acute respiratory failure: an experimental study
    P Pelosi
    Istituto di Anestesia e Rianimazione, , Ospedale Maggiore Policlinico-IRCCS, Milan, Italy
    Am J Respir Crit Care Med 164:122-30. 2001
  10. pmc Positive end-expiratory pressure at minimal respiratory elastance represents the best compromise between mechanical stress and lung aeration in oleic acid induced lung injury
    Alysson Roncally S Carvalho
    Biomedical Engineering Program, COPPE, Federal University of Rio de Janeiro, Av, Horácio Macedo, CT Bloco H 327, 2030, 21941 914, Rio de Janeiro, Brazil
    Crit Care 11:R86. 2007

Detail Information

Publications285 found, 100 shown here

  1. ncbi Respiratory controversies in the critical care setting. Should recruitment maneuvers be used in the management of ALI and ARDS?
    Robert M Kacmarek
    Respiratory Care Services, Massachusetts General Hospital, and Harvard Medical School, Boston, MA 02114, USA
    Respir Care 52:622-31; discussion 631-5. 2007
    ..We explore both sides of the lung recruitment controversy...
  2. ncbi Noninvasive ventilation for treatment of acute respiratory failure in patients undergoing solid organ transplantation: a randomized trial
    M Antonelli
    Istituto di Anestesiologia e Rianimazione, Università Cattolica del Sacro Cuore Rome, Italy
    JAMA 283:235-41. 2000
    ..Noninvasive ventilation (NIV) has been associated with lower rates of endotracheal intubation in populations of patients with acute respiratory failure...
  3. ncbi Noninvasive ventilation in immunosuppressed patients with pulmonary infiltrates, fever, and acute respiratory failure
    G Hilbert
    Division of Medical Intensive Care, University Hospital, Bordeaux, France
    N Engl J Med 344:481-7. 2001
    ..Avoiding intubation is a major goal in the management of respiratory failure, particularly in immunosuppressed patients. Nevertheless, there are only limited data on the efficacy of noninvasive ventilation in these high-risk patients...
  4. ncbi Noninvasive ventilation in severe hypoxemic respiratory failure: a randomized clinical trial
    Miquel Ferrer
    Unitat de Vigilància Intensiva Respiratòria, Institut Clinic de Pneumologia i Cirurgia Toracica, Universitat de Barcelona, Barcelona, Spain
    Am J Respir Crit Care Med 168:1438-44. 2003
    ..39; p=0.017). The use of noninvasive ventilation prevented intubation, reduced the incidence of septic shock, and improved survival in these patients compared with high-concentration oxygen therapy...
  5. ncbi Effects of gas leak on triggering function, humidification, and inspiratory oxygen fraction during noninvasive positive airway pressure ventilation
    Eriko Miyoshi
    Intensive Care Unit, Osaka University Hospital, Japan
    Chest 128:3691-8. 2005
    ..We evaluated the effects of gas leak on inspiratory trigger function during NPPV with bilevel pressure and ICU ventilators. In addition, we evaluated the effects of gas leak on fraction of inspired oxygen (Fio(2)) and humidification...
  6. ncbi Non-invasive pressure support ventilation versus conventional oxygen therapy in acute cardiogenic pulmonary oedema: a randomised trial
    J Masip
    Cardiology Department, Consorci Sanitari Creu Roja de Catalunya, Hospital Creu Roja de Barcelona, University of Barcelona, Spain
    Lancet 356:2126-32. 2000
    ..We assessed the efficacy of this therapy in acute cardiogenic pulmonary oedema in a randomised comparison with conventional oxygen therapy...
  7. ncbi Right ventricular end-diastolic volume index as a predictor of preload status in patients on positive end-expiratory pressure
    M L Cheatham
    Department of Surgical Education, Orlando Regional Medical Center, FL 32806, USA
    Crit Care Med 26:1801-6. 1998
    ....
  8. ncbi ARDSnet ventilatory protocol and alveolar hyperinflation: role of positive end-expiratory pressure
    Salvatore Grasso
    Universita di Bari, Dipartimento dell Emergenza e Trapianti d Organo DETO, Sezione di Anestesiologia e Rianimazione, Ospedale Policlinico, Piazza Giulio Cesare 11, Bari 70124, Italy
    Am J Respir Crit Care Med 176:761-7. 2007
    ....
  9. ncbi Recruitment and derecruitment during acute respiratory failure: an experimental study
    P Pelosi
    Istituto di Anestesia e Rianimazione, , Ospedale Maggiore Policlinico-IRCCS, Milan, Italy
    Am J Respir Crit Care Med 164:122-30. 2001
    ..86, p < 0.0001), suggesting that as more tissue is recruited at end-inspiration, more remains recruited at end-expiration. When superimposed pressure exceeded applied airway pressure (Paw), collapse significantly increased...
  10. pmc Positive end-expiratory pressure at minimal respiratory elastance represents the best compromise between mechanical stress and lung aeration in oleic acid induced lung injury
    Alysson Roncally S Carvalho
    Biomedical Engineering Program, COPPE, Federal University of Rio de Janeiro, Av, Horácio Macedo, CT Bloco H 327, 2030, 21941 914, Rio de Janeiro, Brazil
    Crit Care 11:R86. 2007
    ....
  11. ncbi A chart of failure risk for noninvasive ventilation in patients with COPD exacerbation
    M Confalonieri
    S C Pneumologia, Ospedale di Cattinara, Strada di Fiume, 447, I 34100 Trieste, Italy
    Eur Respir J 25:348-55. 2005
    ....
  12. ncbi Which patients with acute exacerbation of chronic obstructive pulmonary disease benefit from noninvasive positive-pressure ventilation? A systematic review of the literature
    Sean P Keenan
    Royal Columbian Hospital, New Westminster, British Columbia V3L 5E7, Canada
    Ann Intern Med 138:861-70. 2003
    ..Although several trials have been published on the relative effectiveness of this treatment, apparent inconsistencies in study results remain...
  13. pmc Clinical review: Positive end-expiratory pressure and cardiac output
    Thomas Luecke
    Department of Anesthesiology and Critical Care Medicine, University Hospital of Mannheim, Germany
    Crit Care 9:607-21. 2005
    ..Finally, the hemodynamic consequences of PEEP in patients with heart failure, chronic obstructive pulmonary disease and acute respiratory distress syndrome are discussed...
  14. ncbi Positive end-expiratory pressure after a recruitment maneuver prevents both alveolar collapse and recruitment/derecruitment
    Jeffrey M Halter
    Department of Surgery, State University of New York Upstate Medical University, 750 E Adams Street, Syracuse, NY 13210, USA
    Am J Respir Crit Care Med 167:1620-6. 2003
    ..This suggests recruitment followed by inadequate PEEP permits unstable alveoli and may result in ventilator-induced lung injury despite improved oxygenation...
  15. ncbi Recruitment and derecruitment during acute respiratory failure: a clinical study
    S Crotti
    Istituto di Anestesia e Rianimazione, , Ospedale Maggiore Policlinico-IRCCS, Milan, Italy
    Am J Respir Crit Care Med 164:131-40. 2001
    ..When superimposed gravitational pressure exceeded PEEP, end-expiratory collapse increased. We concluded that the rules governing recruitment and derecruitment equally apply in an oleic acid model and in human ALI/ARDS...
  16. ncbi Cardiovascular effects of continuous positive airway pressure in patients with heart failure and obstructive sleep apnea
    Yasuyuki Kaneko
    Sleep Research Laboratories, Toronto Rehabilitation Institute, Toronto General Hospital, ON M5G 2C4, Canada
    N Engl J Med 348:1233-41. 2003
    ..We hypothesized that treatment of obstructive sleep apnea by continuous positive airway pressure in patients with heart failure would improve left ventricular systolic function...
  17. ncbi Outcome in noninvasively and invasively ventilated hematologic patients with acute respiratory failure
    Pieter O Depuydt
    Department of Intensive Care, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium
    Chest 126:1299-306. 2004
    ....
  18. ncbi Noninvasive positive-pressure ventilation in patients with milder chronic obstructive pulmonary disease exacerbations: a randomized controlled trial
    Sean P Keenan
    Sean P Keenan MD, Suite 103, 250 Keary Street, New Westminster, British Columbia, V3L 5E7, Canada
    Respir Care 50:610-6. 2005
    ....
  19. ncbi Positive pressure ventilation in the management of acute and chronic cardiac failure: a systematic review and meta-analysis
    Sunil Nadar
    University Department of Medicine, City Hospital, Birmingham B18 7QH, UK
    Int J Cardiol 99:171-85. 2005
    ..Many trials are still ongoing and the results of these studies would throw more light on the present role of non-invasive ventilation in the management of CHF...
  20. ncbi Effect of the humidification device on the work of breathing during noninvasive ventilation
    Francois Lellouche
    Medical Intensive Care Unit, Hopital Henri Mondor, AP HP, Université Paris 12 et INSERM U492, 51 Av du Marechal de Lattre de Tassigny, 94010 Creteil, France
    Intensive Care Med 28:1582-9. 2002
    ..This study compared the effect of HH and HME during noninvasive ventilation (NIV) on arterial blood gases and patient's effort assessed by respiratory muscles pressure-time product and by work of breathing (WOB)...
  21. ncbi Electrical impedance tomography: a method for monitoring regional lung aeration and tidal volume distribution?
    Inez Frerichs
    Department of Anaesthesiological Research, Centre of Anaesthesiology, Emergency and Intensive Care Medicine, University of Gottingen, Robert Koch Strasse 40, 37075, Gottingen, Germany
    Intensive Care Med 29:2312-6. 2003
    ..To demonstrate the monitoring capacity of modern electrical impedance tomography (EIT) as an indicator of regional lung aeration and tidal volume distribution...
  22. ncbi Noninvasive vs. conventional mechanical ventilation in patients with chronic obstructive pulmonary disease after failure of medical treatment in the ward: a randomized trial
    G Conti
    Universita Cattolica del S Cuore, Policlinico A Gemelli, Largo F Vito, 00168 Rome, Italy
    Intensive Care Med 28:1701-7. 2002
    ....
  23. ncbi Acute respiratory failure in patients with severe community-acquired pneumonia. A prospective randomized evaluation of noninvasive ventilation
    M Confalonieri
    Unità Operativa di Pneumologia, Ospedale Civile di Piacenza, Piacenza, Italy
    Am J Respir Crit Care Med 160:1585-91. 1999
    ..A 2-mo survival advantage was seen in patients with COPD...
  24. ncbi Myocardial infarction rate in acute pulmonary edema: noninvasive pressure support ventilation versus continuous positive airway pressure
    Andrea Bellone
    Emergency Department, Niguarda Ca Granda Hospital, P za Ospedale, Milano, Italy
    Crit Care Med 32:1860-5. 2004
    ..We investigated whether the use of NIPSV increases the incidence of acute myocardial infarction compared with continuous positive airway pressure (CPAP) in patients with acute pulmonary edema...
  25. ncbi Evaluation of an electrical impedance tomography-based Global Inhomogeneity Index for pulmonary ventilation distribution
    Zhanqi Zhao
    Section for Experimental Anesthesiology, Department of Anesthesiology and Critical Care Medicine, University Medical Center, Freiburg, Germany
    Intensive Care Med 35:1900-6. 2009
    ..To evaluate the plausibility, stability, and interindividual comparability of the global inhomogeneity index (GI) based on electrical impedance tomography (EIT)...
  26. ncbi Reducing atelectasis attenuates bacterial growth and translocation in experimental pneumonia
    Anton H van Kaam
    Department of Anesthesiology and Laboratory of Pediatrics, Erasmus MC Faculty, Rotterdam, The Netherlands
    Am J Respir Crit Care Med 169:1046-53. 2004
    ..These findings suggest that minimizing alveolar collapse by exogenous surfactant and open lung ventilation may reduce the risk of pneumonia and subsequent sepsis in ventilated patients...
  27. ncbi Influence of respiratory rate on gas trapping during low volume ventilation of patients with acute lung injury
    Jean Christophe Richard
    Medical Intensive Care Unit, University Hospital Charles Nicolle, 1 rue de Germont, 76031 Rouen, France
    Intensive Care Med 28:1078-83. 2002
    ..The aim of this study was to test whether a high respiratory rate induces significant intrinsic positive end-expiratory pressure (PEEPi) in these patients...
  28. ncbi Mechanical ventilation in acute respiratory failure: recruitment and high positive end-expiratory pressure are necessary
    Carmen Silvia Valente Barbas
    Division of Pulmonary and Critical Care, University of Sao Paulo, Sao Paulo, Brazil and Intensive Care Unit, Albert Einstein Hospital, Sao Paulo, Brazil
    Curr Opin Crit Care 11:18-28. 2005
    ....
  29. ncbi Association of noninvasive ventilation with nosocomial infections and survival in critically ill patients
    E Girou
    Unité d Hygiène et Prévention de l Infection, Hopital Henri Mondor, 94010 Creteil, France
    JAMA 284:2361-7. 2000
    ..Invasive life-support techniques are a major risk factor for nosocomial infection. Noninvasive ventilation (NIV) can be used to avoid endotracheal intubation and may reduce morbidity among patients in intensive care units (ICUs)...
  30. ncbi Leak compensation in positive pressure ventilators: a lung model study
    S Mehta
    Mt Sinai Hospital, University of Toronto, Canada
    Eur Respir J 17:259-67. 2001
    ..Adequate inspiratory flows and durations should be used, triggering sensitivity should be adjusted to prevent autocycling, and a mechanism should be available to limit inspiratory time and avoid I:E ratio inversion...
  31. ncbi Heliox and noninvasive positive-pressure ventilation: a role for heliox in exacerbations of chronic obstructive pulmonary disease?
    Dean R Hess
    Department of Respiratory Care, Massachusetts General Hospital, Boston, MA 02114, USA
    Respir Care 51:640-50. 2006
    ..Lacking such evidence, the use of heliox in patients with COPD exacerbation cannot be considered standard therapy...
  32. ncbi Visual validation of the mechanical stabilizing effects of positive end-expiratory pressure at the alveolar level
    U G McCann
    Department of Surgery, State University of New York Upstate Medical University, 750 East Adams Street, Syracuse, NY 13210. USA
    J Surg Res 99:335-42. 2001
    ..The ability of PEEP to stabilize alveoli and reduce shear during mechanical ventilation has important implications for therapeutic strategies directed at VILI and acute respiratory distress syndrome...
  33. ncbi Higher versus lower positive end-expiratory pressures in patients with the acute respiratory distress syndrome
    Roy G Brower
    Johns Hopkins University, Baltimore, USA
    N Engl J Med 351:327-36. 2004
    ..We conducted this trial to compare the effects of higher and lower PEEP levels on clinical outcomes in these patients...
  34. ncbi Kinetic and reversibility of mechanical ventilation-associated pulmonary and systemic inflammatory response in patients with acute lung injury
    F Stuber
    Department of Anesthesiology and Intensive Care Medicine, University of Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    Intensive Care Med 28:834-41. 2002
    ..To investigate the kinetic and reversibility of mechanical ventilation-associated pulmonary and systemic inflammatory response in patients with acute lung injury (ALI)...
  35. ncbi Comparison of noninvasive positive pressure ventilation with standard medical therapy in hypercapnic acute respiratory failure
    T Celikel
    Department of Pulmonary and Critical Care Medicine, Marmara University Hospital, Istanbul, Turkey
    Chest 114:1636-42. 1998
    ..To compare the efficacy of standard medical therapy (ST) and noninvasive mechanical ventilation additional to standard medical therapy in hypercapnic acute respiratory failure (HARF)...
  36. ncbi Decreased indicators of lung injury with continuous positive expiratory pressure in preterm lambs
    Alan H Jobe
    Division of Pulmonary Biology, Cincinnati Children s Hospital, Cincinnati, Ohio 45229 3039, USA
    Pediatr Res 52:387-92. 2002
    ..05). In this model in preterm lambs CPAP results in lower indicators of acute lung injury than does mechanical ventilation during the first 2 h of life...
  37. ncbi Noninvasive positive pressure ventilation in the acute care setting: where are we?
    N Ambrosino
    Pulmonary and Respiratory Intensive Care Unit, Cardio Thoracic Dept, University Hospital Pisa, Italy
    Eur Respir J 31:874-86. 2008
    ..Additionally, the technique must be applied in the appropriate location by a trained team in order to avoid disappointing results...
  38. ncbi The assessment of regional lung mechanics with electrical impedance tomography: a pilot study during recruitment manoeuvres
    Caroline A Grant
    Paediatric Intensive Care Unit, Mater Children s Hospital, South Brisbane, QLD, 4101, Australia
    Intensive Care Med 35:166-70. 2009
    ..Respiratory mechanics and regional filling capacity of the lung were measured using EIT pre- and post- recruitment and compared to a control group...
  39. ncbi Pressure-controlled versus volume-controlled ventilation during one-lung ventilation for thoracic surgery
    M Carmen Unzueta
    Department of Anesthesiology, Hospital de Sant Pau, Barcelona, Spain
    Anesth Analg 104:1029-33, tables of contents. 2007
    ..In this study we investigated whether PCV results in improved arterial oxygenation compared with volume-controlled ventilation (VCV) during OLV...
  40. pmc PEEP titration guided by ventilation homogeneity: a feasibility study using electrical impedance tomography
    Zhanqi Zhao
    Department of Biomedical Engineering, Furtwangen University, Jakob Kienzle Strasse 17, D 78054 Villingen Schwenningen, Germany
    Crit Care 14:R8. 2010
    ..The aim of this study was to test the feasibility of PEEP titration guided by ventilation homogeneity using the global inhomogeneity (GI) index based on electrical impedance tomography (EIT) images...
  41. ncbi Adaptive pressure support servo-ventilation: a novel treatment for Cheyne-Stokes respiration in heart failure
    H Teschler
    Faculty of Medicine, Ruhrlandklinik, University of Essen, Essen, Germany
    Am J Respir Crit Care Med 164:614-9. 2001
    ..All subjects preferred ASV to CPAP. One night ASV suppresses central sleep apnea and/or CSR (CSA/CSR) in heart failure and improves sleep quality better than CPAP or 2 L/min oxygen...
  42. ncbi Measurement of air trapping, intrinsic positive end-expiratory pressure, and dynamic hyperinflation in mechanically ventilated patients
    Lluis Blanch
    Critical Care Center, Hospital de Sadabell, Institut Universitari Fundació Parc Taulí, Corporacio Parc Tauli, Universitad Autonoma de Barcelona, Sadabell, Spain
    Respir Care 50:110-23; discussion 123-4. 2005
    ..Ventilator graphics are invaluable for monitoring and treatment decisions at the bedside...
  43. ncbi Prevention of atelectasis formation during induction of general anesthesia
    Marco Rusca
    Departments of Anesthesiology, University Hospital, Lausanne, Switzerland
    Anesth Analg 97:1835-9. 2003
    ..005). Atelectasis formation is prevented by application of PEEP during the anesthesia induction despite the use of large oxygen concentrations, resulting in improved oxygenation...
  44. ncbi Effects of mechanical ventilation on release of cytokines into systemic circulation in patients with normal pulmonary function
    H Wrigge
    Department of Anesthesiology and Intensive Care Medicine, University of Bonn, Germany
    Anesthesiology 93:1413-7. 2000
    ....
  45. ncbi Non-invasive pressure support ventilation in severe community-acquired pneumonia
    P Jolliet
    Medical Intensive Care Division, University Hospital, Geneva, Switzerland
    Intensive Care Med 27:812-21. 2001
    ....
  46. ncbi Predicting the result of noninvasive ventilation in severe acute exacerbations of patients with chronic airflow limitation
    A Anton
    Department of Respiratory Medicine, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Barcelona, Spain
    Chest 117:828-33. 2000
    ....
  47. ncbi Cardiovascular issues in respiratory care
    Michael R Pinsky
    Bioengineering and Anesthesiology, Department of Critical Care Medicine, University of Pittsburgh Medical Center, 606 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA 15213, USA
    Chest 128:592S-597S. 2005
    ..In patients with hypervolemic heart failure, this afterload reducing effect can result in improved LV ejection, increased cardiac output, and reduced myocardial oxygen demand...
  48. ncbi Effect of mechanical ventilation on inflammatory mediators in patients with acute respiratory distress syndrome: a randomized controlled trial
    V M Ranieri
    Istituto di Anestesiologia e Rianimazione, Universita di Bari, Ospedale Policlinico, Italy
    JAMA 282:54-61. 1999
    ....
  49. pmc Mechanical ventilation guided by esophageal pressure in acute lung injury
    Daniel Talmor
    Department of Anesthesia, Critical Care, and Pain Medicine, Beth Israel Deaconess Medical Center, Boston 02215, USA
    N Engl J Med 359:2095-104. 2008
    ....
  50. ncbi Lung protective ventilatory strategies in very low birth weight infants
    R Ramanathan
    Division of Neonatal Medicine, Department of Pediatrics, Women s and Children s Hospital and Childrens Hospital Los Angeles, Keck School of Medicine University of Southern California, Los Angeles, CA, USA
    J Perinatol 28:S41-6. 2008
    ..Initial steps in the management of preterm infants may also include sustained inflation to establish functional residual capacity, followed by noninvasive ventilation to minimize lung injury and subsequent development of BPD...
  51. ncbi Helium-oxygen versus air-oxygen noninvasive pressure support in decompensated chronic obstructive disease: A prospective, multicenter study
    Philippe Jolliet
    Medical Intensive Care Division, University Hospital, Geneva, Switzerland
    Crit Care Med 31:878-84. 2003
    ....
  52. ncbi Optimal oxygen concentration during induction of general anesthesia
    Lennart Edmark
    Department of Anesthesiology and Intensive Care, Central Hospital, Vasteras, and Research Associate, Department of Medical Sciences, Clinical Physiology, University Hospital, Uppsala, Sweden
    Anesthesiology 98:28-33. 2003
    ..The use of 100% oxygen during induction of anesthesia may produce atelectasis. The authors investigated how different oxygen concentrations affect the formation of atelectasis and the fall in arterial oxygen saturation during apnea...
  53. ncbi Alveolar recruitment in combination with sufficient positive end-expiratory pressure increases oxygenation and lung aeration in patients with severe chest trauma
    Dierk Schreiter
    Surgical Intensive Care Unit, Department of Surgery, University Hospital Leipzig, Leipzig, Germany
    Crit Care Med 32:968-75. 2004
    ..Investigation of oxygenation and lung aeration during mechanical ventilation according to the open lung concept in patients with acute lung injury or acute respiratory distress syndrome...
  54. pmc The effect of non-invasive positive pressure ventilation (NIPPV) on cognitive function in amyotrophic lateral sclerosis (ALS): a prospective study
    I C Newsom-Davis
    Department of Psychology, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK
    J Neurol Neurosurg Psychiatry 71:482-7. 2001
    ..These deficits may be partially improved by NIPPV over a 6 week period. This has important implications for investigations of both cognitive dysfunction in non-demented patients with ALS, and the effect of ventilation on quality of life...
  55. ncbi A decremental PEEP trial identifies the PEEP level that maintains oxygenation after lung recruitment
    Karim Girgis
    Surgical Intensive Care Unit, New Kasr El Aini Teaching Hospital and Cairo University, Cairo, Egypt
    Respir Care 51:1132-9. 2006
    ..To assess the ability of a decremental trial of positive end-expiratory pressure (PEEP) to identify an optimal PEEP level that maintains oxygenation after a lung-recruitment maneuver...
  56. ncbi Sigh in supine and prone position during acute respiratory distress syndrome
    Paolo Pelosi
    Dipartimento di Scienze Cliniche e Biologiche, Universita degli Studi dell Insubria, Ospedale di Circolo, Fondazione Macchi, Varese
    Am J Respir Crit Care Med 167:521-7. 2003
    ..82, p < 0.001). We conclude that adding a recruitment maneuver such as cyclical sighs during ventilation in the prone position may provide optimal lung recruitment in the early stage of ARDS...
  57. ncbi Impact of ventilation parameters and duration of ventilator use on non-invasive home ventilation in restrictive thoracic disorders
    Stephan Budweiser
    Centre of Pneumology, Hospital Donaustauf, Donaustauf, Germany
    Respiration 73:488-94. 2006
    ..Non-invasive positive pressure ventilation (NPPV) is an accepted treatment option for chronic ventilatory failure due to restrictive thoracic disorders...
  58. ncbi Effectiveness and side effects of closed and open suctioning: an experimental evaluation
    Sophie Lindgren
    Department of Anaesthesia and Intensive Care, Sahlgrenska University Hospital, 413 45 Gothenburg, Sweden
    Intensive Care Med 30:1630-7. 2004
    ....
  59. ncbi Dynamic mechanical consequences of deep inflation in mice depend on type and degree of lung injury
    Gilman Allen
    Department of Medicine, Vermont Lung Center, University of Vermont, Bulington, Vermont 05405 0075, USA
    J Appl Physiol (1985) 96:293-300. 2004
    ..001). We conclude that the effects of DIs in acute lung injury depend on the degree of lung injury but only to the extent that this injury reflects a disruption of the air-liquid interface...
  60. ncbi The evidence for noninvasive positive-pressure ventilation in the care of patients in acute respiratory failure: a systematic review of the literature
    Dean R Hess
    Department of Respiratory Care, Massachusetts General Hospital, Boston MA 02114, USA
    Respir Care 49:810-29. 2004
    ..Inhaled bronchodilators can be administered during NPPV, and NPPV can be delivered with helium-oxygen mixture. Institution-specific practice guidelines may be useful to improve NPPV success...
  61. ncbi A pilot prospective, randomized, placebo-controlled trial of bilevel positive airway pressure in acute asthmatic attack
    Arie Soroksky
    Pulmonary Institute, Assaf Harofeh Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Israel
    Chest 123:1018-25. 2003
    ....
  62. pmc Positive end-expiratory pressure in acute respiratory distress syndrome: should the 'open lung strategy' be replaced by a 'protective lung strategy'?
    Jean Jacques Rouby
    Réanimation Chirurgicale Polyvalente Pierre Viars, Groupe Hospitalier Pitie Salpetriere, Assistance Publique Hopitaux de Paris, Université Pierre et Marie Curie of Paris 6, 47 83 boulevard de l Hopital, Paris Cedex 13, France
    Crit Care 11:180. 2007
    ..The best positive end-expiratory pressure should correspond to the best compromise between recruitment and distension, a condition that coincides with the best respiratory elastance...
  63. ncbi Effects of cyclic opening and closing at low- and high-volume ventilation on bronchoalveolar lavage cytokines
    Eric K Chu
    Department of Medicine and Critical Care Medicine, St Michael s Hospital, University of Toronto, Ontario, Canada
    Crit Care Med 32:168-74. 2004
    ..To examine the mechanisms of ventilator-induced lung injury at low and high lung volumes...
  64. ncbi Ventilation strategy using low tidal volumes, recruitment maneuvers, and high positive end-expiratory pressure for acute lung injury and acute respiratory distress syndrome: a randomized controlled trial
    Maureen O Meade
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    JAMA 299:637-45. 2008
    ..Low-tidal-volume ventilation reduces mortality in critically ill patients with acute lung injury and acute respiratory distress syndrome. Instituting additional strategies to open collapsed lung tissue may further reduce mortality...
  65. ncbi Low tidal volume reduces epithelial and endothelial injury in acid-injured rat lungs
    James A Frank
    Cardiovascular Research Institute and the Department of Medicine, University of California, San Francisco, San Francisco, California 94143 0130, USA
    Am J Respir Crit Care Med 165:242-9. 2002
    ..The additional decrease in pulmonary edema with a tidal volume of 3 ml/kg is partly accounted for by greater protection of the alveolar epithelium...
  66. ncbi Lower inflection point and recruitment with PEEP in ventilated patients with acute respiratory failure
    M Mergoni
    Servizio di Anestesia e Rianimazione, Azienda Ospedaliera di Parma, 43100 Parma, Italy
    J Appl Physiol (1985) 91:441-50. 2001
    ..A RV was found even when a LIP was not present. We conclude that the recruitment phenomenon is not closely related to the presence of a LIP and that a simple method can be used to measure RV...
  67. ncbi Elastic properties of the lung and the chest wall in young and adult healthy pigs
    E De Robertis
    Dept of Clinical Physiology, University Hospital of Lund, Sweden
    Eur Respir J 17:703-11. 2001
    ..A strong tendency to lung collapse contributes to a complex pattern of elastic pressure/volume curves. At low volumes and distending pressures the chest wall contributes significantly to changes in respiratory system elastance...
  68. ncbi Positive end-expiratory pressure titration in acute respiratory distress syndrome patients: impact on right ventricular outflow impedance evaluated by pulmonary artery Doppler flow velocity measurements
    J M Schmitt
    Medical Intensive Care Unit, , , Boulogne, France
    Crit Care Med 29:1154-8. 2001
    ..Application of PEEPA worsened RV systolic function impairment produced by tidal ventilation. Conversely, application of PEEPS reduced RV systolic function impairment, suggesting an association with a lower pulmonary vascular resistance...
  69. ncbi A meta-analysis of noninvasive weaning to facilitate liberation from mechanical ventilation
    Karen E A Burns
    Division of Critical Care Medicine, London Health Sciences Centre Victoria Hospital
    Can J Anaesth 53:305-15. 2006
    ....
  70. ncbi Short-term effects of expiration under positive pressure in patients with acute exacerbation of chronic obstructive pulmonary disease and mild acidosis requiring non-invasive positive pressure ventilation
    Andrea Bellone
    Respiratory Intensive Care Unit, San Sebastiano Hospital, Emilia, Italy
    Intensive Care Med 28:581-5. 2002
    ....
  71. ncbi High-frequency oscillatory ventilation: effects on lung function, mechanics, and airway cytokines in the immature baboon model for neonatal chronic lung disease
    B A Yoder
    Southwest Foundation for Biomedical Research, San Antonio, Texas, USA
    Am J Respir Crit Care Med 162:1867-76. 2000
    ..Though enhanced alveolization was not observed, HFOV for 1 to 2 mo resulted in consistently more uniform lung inflation than LV-PPV...
  72. ncbi Influence of positive airway pressure on the pressure gradient for venous return in humans
    H Jellinek
    Department of Anesthesiology and Intensive Care Medicine, Community Hospital of Lainz, A 1130 Vienna, Austria
    J Appl Physiol (1985) 88:926-32. 2000
    ..In conclusion, we demonstrated that positive Paw equally increases Pra and Pms in humans and alters venous return without changes in the pressure gradient (Pms - Pra)...
  73. ncbi Positive end-expiratory pressure setting in adults with acute lung injury and acute respiratory distress syndrome: a randomized controlled trial
    Alain Mercat
    Département de Réanimation Médicale et Médecine Hyperbare, CHU d Angers, Angers, France
    JAMA 299:646-55. 2008
    ..The need for lung protection is universally accepted, but the optimal level of positive end-expiratory pressure (PEEP) in patients with acute lung injury (ALI) or acute respiratory distress syndrome remains debated...
  74. pmc Survey of non-invasive ventilation (NIPPV) in patients with acute exacerbations of chronic obstructive pulmonary disease (COPD) in the UK
    M J Doherty
    Medical Chest Unit, Castle Hill Hospital, Cottingham, East Yorkshire, UK
    Thorax 53:863-6. 1998
    ..In those in which it is available it is generally underused. Lack of training and problems with funding are generally given for the failure to introduce NIPPV...
  75. ncbi Noninvasive proportional assist ventilation for acute respiratory insufficiency. Comparison with pressure support ventilation
    P C Gay
    Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, Minnesota, USA
    Am J Respir Crit Care Med 164:1606-11. 2001
    ..Compared with PSV delivered with the Puritan-Bennett 7200ae, PAV is associated with more rapid improvements in some physiologic variables and is better tolerated...
  76. ncbi Pulmonary gas distribution during ventilation with different inspiratory flow patterns in experimental lung injury -- a computed tomography study
    H Roth
    Department of Anesthesiology and Critical Care, University Hospital of Mannheim, Faculty of Clinical Medicine, University of Heidelberg, Heidelberg, Germany
    Acta Anaesthesiol Scand 48:851-61. 2004
    ....
  77. ncbi Effects of non-invasive ventilation on survival and quality of life in patients with amyotrophic lateral sclerosis: a randomised controlled trial
    Stephen C Bourke
    Department of Respiratory Medicine, University of Newcastle upon Tyne and the Newcastle Hospitals Trust, Newcastle upon Tyne, UK
    Lancet Neurol 5:140-7. 2006
    ..We aimed to assess the effect of NIV on quality of life and survival in amyotrophic lateral sclerosis in a randomised controlled trial...
  78. ncbi Objective measures of the efficacy of noninvasive positive-pressure ventilation in amyotrophic lateral sclerosis
    L S Aboussouan
    Division of Pulmonary and Critical Care Medicine, Wayne State University School of Medicine, Harper Hospital, 3 Hudson, 3990 John R, Detroit, Michigan 48201, USA
    Muscle Nerve 24:403-9. 2001
    ..002). Although NIPPV has no impact on the rate of decline of lung function and may have deleterious effects on spirometric measures, it may improve quality of life and survival...
  79. ncbi Determinants of Fi,O2 with oxygen supplementation during noninvasive two-level positive pressure ventilation
    F Thys
    Emergency Dept, Cliniques Universitaires Saint Luc, Universite Catholique de Louvain, Brussels, Belgium
    Eur Respir J 19:653-7. 2002
    ..If inspiratory airway pressure levels are >12 cmH2O, oxygen flows should be at least 4 L x min(-1)...
  80. ncbi Effect of positive pressure on venous return in volume-loaded cardiac surgical patients
    Paul C M van den Berg
    Department of Intensive Care, Leiden University Medical Centre, 2300 RC Leiden, The Netherlands
    J Appl Physiol (1985) 92:1223-31. 2002
    ....
  81. ncbi A prospective, randomized trial of BiPAP in severe acute congestive heart failure
    M A Levitt
    Department of Emergency Medicine, Alameda County Medical Center-Highland Campus, Oakland, California, USA
    J Emerg Med 21:363-9. 2001
    ..An increase in AMI rate with BiPAP was not found in this study as previously reported. This study provides support for a larger clinical trial assessing the safety and efficacy of BiPAP in acute CHF...
  82. ncbi Lung recruitment during small tidal volume ventilation allows minimal positive end-expiratory pressure without augmenting lung injury
    P C Rimensberger
    Department of Critical Care, The Hospital for Sick Children, University of Toronto, Ontario, Canada
    Crit Care Med 27:1940-5. 1999
    ....
  83. ncbi Noninvasive positive pressure ventilation: five years of experience in a pediatric intensive care unit
    Sandrine Essouri
    Pediatric Intensive Care Unit, Kremlin Bicetre Hospital, Assistance Publique Hopitaux de Paris, Kremlin Bicetre, France
    Pediatr Crit Care Med 7:329-34. 2006
    ..To evaluate the feasibility and outcome of noninvasive positive pressure ventilation (NPPV) in daily clinical practice...
  84. ncbi Effects of training with heliox and noninvasive positive pressure ventilation on exercise ability in patients with severe COPD
    James E Johnson
    Cardiopulmonary Rehabilitation, University of Alabama at Birmingham, Birmingham, AL, USA
    Chest 122:464-72. 2002
    ....
  85. ncbi Supramaximal inflation improves lung compliance in subjects with amyotrophic lateral sclerosis
    Noah Lechtzin
    Department of Internal Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Chest 129:1322-9. 2006
    ..Noninvasive positive-pressure ventilation (NPPV) prolongs survival in ALS patients but may also have additional beneficial effects...
  86. ncbi Pattern of lung emptying and expiratory resistance in mechanically ventilated patients with chronic obstructive pulmonary disease
    Eumorfia Kondili
    Department of Intensive Care Medicine, University Hospital of Heraklion, University of Crete, 711 10 Heraklion, Crete, Greece
    Intensive Care Med 30:1311-8. 2004
    ..To study the pattern of lung emptying and expiratory resistance in mechanically ventilated patients with chronic obstructive pulmonary disease (COPD)...
  87. pmc Esophageal and transpulmonary pressures in acute respiratory failure
    Daniel Talmor
    Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA, USA
    Crit Care Med 34:1389-94. 2006
    ..By measuring esophageal pressure (Pes), we sought to characterize influence of the chest wall on Ppl and transpulmonary pressure (PL) in patients with acute respiratory failure...
  88. ncbi Pressure-volume curve does not predict steady-state lung volume in canine lavage lung injury
    John M Downie
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Am J Respir Crit Care Med 169:957-62. 2004
    ..These results support the interpretation of Pflex as pressure threshold for recruitment, but otherwise do not suggest a role for the pressure-volume curve in predicting steady-state lung volume...
  89. ncbi Influence of low tidal volumes on gas exchange in acute respiratory distress syndrome and the role of recruitment maneuvers
    Jay A Johannigman
    Department of Surgery, University of Cincinnati, Ohio 45267 0558, USA
    J Trauma 54:320-5. 2003
    ..BACKGROUND Use of a low tidal volume (V(T)) strategy in the treatment of acute respiratory distress syndrome can lead to a decrease in oxygenation. This study evaluated the safety and efficacy of a recruitment maneuver (RM) in this setting...
  90. pmc A comparison of biologically variable ventilation to recruitment manoeuvres in a porcine model of acute lung injury
    Duane J Funk
    Department of Anaesthesia, University of Manitoba, Winnipeg, Manitoba, Canada
    Respir Res 5:22. 2004
    ....
  91. ncbi Noninvasive ventilation in cardiogenic pulmonary edema: a multicenter randomized trial
    Stefano Nava
    Respiratory Intensive Care Unit, Istituto Scientifico di Pavia, Fondazione S Maugeri, 27100 Pavia, Italy
    Am J Respir Crit Care Med 168:1432-7. 2003
    ..Noninvasive pressure support ventilation does, however, reduce the intubation rate in the subgroup of hypercapnic patients...
  92. ncbi Lower tidal volume ventilation and plasma cytokine markers of inflammation in patients with acute lung injury
    Polly E Parsons
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Fletcher Allen Health Care, University of Vermont, USA
    Crit Care Med 33:1-6; discussion 230-2. 2005
    ....
  93. ncbi GI complications in patients receiving mechanical ventilation
    G M Mutlu
    Section of Respiratory and Critical Care Medicine, University of Illinois at Chicago, Chicago, IL, USA
    Chest 119:1222-41. 2001
    ..Incorporated in this review are discussions of the most prevalent GI complications associated with MV, and current diagnosis and management of these problems...
  94. ncbi Positive end-expiratory pressure modulates local and systemic inflammatory responses in a sepsis-induced lung injury model
    Maria Teresa Herrera
    Research Institute, Hospital Universitario N S de Candelaria, Carretera del Rosario s n, 38010, Santa Cruz de Tenerife, Canary Islands, Spain
    Intensive Care Med 29:1345-53. 2003
    ..We examined the effects of positive end-expiratory pressure (PEEP) in the setting of a clinically relevant, in vivo animal model of sepsis-induced acute lung injury ventilated with low or injurious tidal volume...
  95. ncbi Systematic review of noninvasive positive pressure ventilation in severe stable COPD
    M A Kolodziej
    Dept of Pulmonary Medicine, Faculty of Medicine and Dentistry, University of Alberta Hospitals, University of Alberta, Edmonton, AB, Canada
    Eur Respir J 30:293-306. 2007
    ....
  96. ncbi High tidal volume and positive fluid balance are associated with worse outcome in acute lung injury
    Yasser Sakr
    Department of Intensive Care, Erasme Hospital, University of Brussels, Belgium
    Chest 128:3098-108. 2005
    ..We tested the hypothesis that infection/sepsis and use of higher tidal volumes than those applied in the ARDS Network (ARDSnet) study (> 7.4 mL/kg of predicted body weight) would worsen outcome in patients with ALI/ARDS...
  97. ncbi Lung recruitment in patients with the acute respiratory distress syndrome
    Luciano Gattinoni
    Istituto di Anestesiologia e Rianimazione, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico, Ospedale Maggiore Policlinico, Mangiagalli, Regina Elena di Milano, Universita degli Studi di Milano, Milan, Italy
    N Engl J Med 354:1775-86. 2006
    ....
  98. ncbi Effects of recruitment maneuvers in patients with acute lung injury and acute respiratory distress syndrome ventilated with high positive end-expiratory pressure
    Roy G Brower
    Crit Care Med 31:2592-7. 2003
    ..Beneficial effects on gas exchange in responders appear to be of brief duration. More information is needed to determine the role of recruitment maneuvers in the management of ALI/ARDS...
  99. ncbi Predictors of failure of noninvasive positive pressure ventilation in patients with acute hypoxemic respiratory failure: a multi-center study
    M Antonelli
    Istituto di Anestesiologia e Rianimazione, Universita Cattolica del Sacro Cuore, Policlinico A Gemelli, Largo A Gemelli 8, 00168 Rome, Italy
    Intensive Care Med 27:1718-28. 2001
    ..In these patients, predictors of NPPV failure are not well characterized...
  100. ncbi Safety and efficacy of a sustained inflation for alveolar recruitment in adults with respiratory failure
    S E Lapinsky
    Department of Medicine, Mount Sinai Hospital, Ontario, Canada
    Intensive Care Med 25:1297-301. 1999
    ..To assess the safety and efficacy of a sustained inflation, used as a lung volume recruitment maneuver in ventilated patients with hypoxemic respiratory failure...
  101. pmc Respiratory effects of different recruitment maneuvers in acute respiratory distress syndrome
    Jean Michel Constantin
    General Intensive Care Unit, Hotel Dieu Hospital, University Hospital of Clermont Ferrand, Boulevard L, Malfreyt, 63058 Clermond Ferrand, France
    Crit Care 12:R50. 2008
    ..Alveolar derecruitment may occur during low tidal volume ventilation and may be prevented by recruitment maneuvers (RMs). The aim of this study was to compare two RMs in acute respiratory distress syndrome (ARDS) patients...

Research Grants62

  1. Stretch and Hyperoxia in Ventilator-induced Lung Injury
    Scott E Sinclair; Fiscal Year: 2010
    ....
  2. Critical Role of Alveolar Fibrin in Acute Lung Injury
    Gilman Allen; Fiscal Year: 2008
    ..abstract_text> ..
  3. Respiratory Control Stability in Obstructive Sleep Apnea
    David Wellman; Fiscal Year: 2004
    ..b. High LG, independent of upper airway collapsibility, is associated with more severe (more frequently apneas) OSA. c. Lower LG will reduce OSA severity in patients with high LG. ..
  4. Pathogenesis and Genetics of Obstructive Sleep Apnea
    Richard Schwab; Fiscal Year: 2006
    ..To address these specific aims, we have planned a logical series of studies that will provide insight in the pathogenesis of obstructive sleep apnea and the anatomic risk factors for this condition. ..
  5. Aging Influence on the Development of Sleep Apnea
    Atul Malhotra; Fiscal Year: 2007
    ..abstract_text> ..
  6. Sleep Apnea and Obesity: Cardiovascular Risk Assessment
    Atul Malhotra; Fiscal Year: 2008
    ..This data may have important implications for the diagnosis and treatment of these abnormalities. ..
  7. ECG-derived estimators of sleep physiology
    Robert Thomas; Fiscal Year: 2006
    ..3) To correlate the biomarker with excessive daytime sleepiness, subjective sleep quality and cardiovascular morbidity (SHHS), and reduced neurocognitive function (NAPS). ..
  8. WORKING MEMORY IN OBSTRUCTIVE SLEEP APNEA-AN fMRI STUDY
    Robert Thomas; Fiscal Year: 2006
    ..abstract_text> ..
  9. Noninvasive Ventilation in Children with Cystic Fibrosis
    CAROLE MARCUS; Fiscal Year: 2004
    ..In keeping with the mission of the RFA, this study will use a multidisciplinary approach to improve management and enhance the quality of life in children with chronic respiratory failure. ..
  10. Ventilator-Induced Lung Injury:Mechanisms & Consequences
    Scott Sinclair; Fiscal Year: 2005
    ..Aim 3A: Document cyclical airway collapse and reopening via changes in regional ventilation distribution. Aim 3B: Validate a method to estimate appropriate PEEP level to prevent cyclical airway collapse. ..
  11. PATHOPHYSIOLOGY OF CHILDHOOD OBSTRUCTIVE SLEEP APNEA
    CAROLE MARCUS; Fiscal Year: 2008
    ..These studies will help elucidate the pathophysiology of OSAS in obese adolescents, ultimately resulting in improved management of this disease. ..
  12. Family Linkage Study of Obstructive Sleep Apnea
    Allan Pack; Fiscal Year: 2007
    ..abstract_text> ..
  13. Quantifying Left Ventricular Ejection Effectiveness
    Michael Pinsky; Fiscal Year: 2007
    ..The ultimate goal of this proposal is to develop and validate an echocardiographic-based algorithm that quantifies LV ejection effectiveness by merging both power and synchrony of contraction into a common metric. ..
  14. RURAL DWELLING OLDER ADULTS: CPAP ADHERENCE SUPPORT
    Carol Smith; Fiscal Year: 2004
    ..abstract_text> ..
  15. Sleep Apnea and Hypertension: Role of SNS
    Joel Dimsdale; Fiscal Year: 2008
    ....
  16. Sleep-Health & Knowledge in U.S. Hispanics
    JOSE LOREDO; Fiscal Year: 2009
    ..S. Mexican-American Hispanics should include intensive focus on Sleep Health and Sleep Health knowledge deficits. Key Words: Sleep disorders;Minority health;Epidemiology. ..
  17. Clinical Trials of FTI Radiosensitization
    Stephen Hahn; Fiscal Year: 2005
    ..Specific molecular markers that are associated with activation of the Ras signaling pathway will be measured in NSCLC tumor biopsy specimens and will be related to the clinical efficacy of R115777 and radiotherapy. ..
  18. TREATMENT OF SLEEP APNEA IN THE ELDERLY
    Allan Pack; Fiscal Year: 2003
    ..These data will give novel definitive information both about identification and treatment of sleep apnea in the elderly. ..
  19. STRESS, BLOOD PRESSURE AND ETHNICITY
    Joel E Dimsdale; Fiscal Year: 2010
    ..The study scrutinizes sleep, inflammation, vasodilation, autonomic functioning, and baroreflex regulation. We hypothesize that adversity has a stronger impact on cardiovascular pathophysiology than does ethnicity. ..
  20. Sleep/Wake Contiuum in Lewy Body Disease
    Donald L Bliwise; Fiscal Year: 2010
    ..The proposed work will also provide important clinical insights into disease correlates and disease course across the broad spectrum of Parkinsonism. ..
  21. Integrative Models of Neural Adaptive Control
    Chi Sang Poon; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  22. SYNAPTIC MECHANISMS IN RESPIRATORY CONTROL
    Chi Sang Poon; Fiscal Year: 2002
    ..Five specific aims are proposed to investigate these mechanisms. The results obtained will provide valuable insights into the mechanisms of afferent signal integration in the NTS and the corresponding effects on respiratory control. ..
  23. EFFECTS OF STATINS ON PULMONARY HYPERTENSION
    Reda Girgis; Fiscal Year: 2007
    ..This award will allow the candidate to develop into a well-trained independent researcher in PH. ..
  24. Xth Oxford Conference on Modeling and Control of Breathing
    Chi Sang Poon; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  25. DETERMINANTS OF EXACERBATION FREQUENCY IN PATIENTS WITH*
    Jadwiga Wedzicha; Fiscal Year: 2007
    ..abstract_text> ..
  26. PREDOCTORAL TRAINING PROGRAM IN NEUROSCIENCE
    RALPH FREGOSI; Fiscal Year: 2008
    ..Facilities for research training include the extensive equipment and expertise in individual faculty laboratories, as well as comprehensive shared resources at the University of Arizona. ..
  27. TWO NOVEL CPLA2 BINDING PROTEINS AND CELL DEATH
    JOSEPH VINCENT BONVENTRE; Fiscal Year: 2010
    ..Given the large number of patients that are initiated on dialysis each year, this addresses a critical public health problem. ..
  28. Nonlinear Analysis of Heart Rate Variability
    Chi Sang Poon; Fiscal Year: 2009
    ..These clinical and modeling studies in turn will showcase the proposed analytical techniques thereby paving the way for their application to other complex biomedical modeling and analysis problems in general. ..
  29. RESPIRATORY RELATED MOTOR OUTPUT TO UPPER AIRWAY MUSLCES
    SAMUEL KUNA; Fiscal Year: 2003
    ..This work is an expansion of work conducted to date by the PI, who has recently relocated to the University of Pennsylvania. ..
  30. Effects of sex and fat distribution on sleep disordered breathing
    Philip L Smith; Fiscal Year: 2010
    ..The studies also provide insights into the neurohumoral regulation of upper airway function. ..
  31. Pontomedullary Integration of Respiratory Afferents
    Chi Sang Poon; Fiscal Year: 2010
    ....
  32. Angiogenesis in the Lung
    Elizabeth Wagner; Fiscal Year: 2010
    ..In an animal model of chronic pulmonary thromboembolic disease, this project will determine the inflammatory cytokines and cells responsible for new vessel growth, and pharmacological and interventional inhibitors. ..
  33. Improving Respiratory Outcomes in ALS
    Noah Lechtzin; Fiscal Year: 2006
    ..Lechtzin the opportunity to expand the skills required for development into an independent clinical investigator. ..
  34. Impact of CPAP on Functional Outcomes in Milder OSA
    Terri Weaver; Fiscal Year: 2006
    ..Secondary aims of the study are: 1) to examine whether CPAP also improves daytime sleepiness; 2) to determine whether CPAP can reduce nocturnal blood pressure to lower the risk for stroke and hypertension linked to OSA. ..
  35. AIRWAY PARTICLE CLEARANCE--ROLE OF BRONCHIAL CIRCULATION
    Elizabeth Wagner; Fiscal Year: 2001
    ..Furthermore, the results will contribute to an understanding of the factors that both limit and enhance uptake and distribution of aerosols. ..
  36. NEUROMUSCULAR CONTROL OF THE PHARYNGEAL AIRWAY
    RALPH FREGOSI; Fiscal Year: 2002
    ..These experiments will lay the foundation for new and improved treatment strategies for persons with obstructive sleep apnea or with other conditions that are caused by malfunction of the tongue motor system. ..
  37. SUNDOWN SYNDROME IN A SKILLED NURSING FACILITY
    Donald Bliwise; Fiscal Year: 2002
    ..These results will provide information on the mechanistic basis for sundowning in aged patients with dementing disorders. ..
  38. METALLOPROTEINASES IN VENTILATOR-INDUCED LUNG INJURY
    Hussein Foda; Fiscal Year: 2003
    ..By better understanding the mechanisms that lead to ventilator-induced lung injury, therapeutic strategies may be devised to improve the outcome in this highly fatal condition. ..
  39. CHEMORECEPTORS AND HYPERTENSION AND SLEEP APNEA
    JOSE LOREDO; Fiscal Year: 2003
    ..This training will provide the basis of an MPH degree and a solid theoretical background for future conduct of quality clinical research. ..
  40. FACILITATION OF EPILEPTIC ACTIVITY BY SLEEP AND AROUSAL
    Beth Malow; Fiscal Year: 2003
    ..abstract_text> ..
  41. MODULATION OF OXIDANT INJURY BY FGF-10
    Daya Upadhyay; Fiscal Year: 2003
    ..My proposed work will enable me to understand the molecular and biological basis of the pathophysiology of acute respiratory distress syndrome and pulmonary fibrosis. ..
  42. Effects of Treating Obstructive Sleep Apnea in Epilepsy
    Beth Malow; Fiscal Year: 2004
    ..Develop quality control measures to ensure accurate and consistent data collection among sites in the RCT, including aspects related to remote data entry and standardization of performance and interpretation of PSG studies across sites...
  43. VENTILATOR-ASSOCIATED ALVEOLAR EPITHELIAL INJURY
    James Frank; Fiscal Year: 2006
    ..This research and comprehensive career development plan will prepare me to become an independent investigator in the mechanisms of alveolar epithelial injury and ventilator-associated lung injury. ..
  44. Neuromorphic Electronic Model of Synaptic Plasticity
    Chi Sang Poon; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  45. Pulmonary delivery of nicotine using the AERx System
    Stephen Farr; Fiscal Year: 2005
    ..The long-term goal of this proposed project is to develop an inhalation product (the AERx-nicotine) as a therapy for smoking cessation. ..
  46. Molecular Targets for Drug and Radiation Sensitivity
    Stephen Hahn; Fiscal Year: 2007
    ..abstract_text> ..
  47. Melatonin for Sleep in Children with Autism: Safety, Tolerability, and Dosing
    Beth Malow; Fiscal Year: 2009
    ..We will determine the response of melatonin dose on sleep latency using polysomnography and actigraphy, a validated and non-intrusive measure of sleep onset and duration. Adverse events will also be captured. ..
  48. PHARYNGEAL AIRWAY FUNCTION
    SAMUEL KUNA; Fiscal Year: 2003
    ....
  49. MICROARRAY EXPRESSION PROFILING OF RODENT MODELS OF HUMA
    Allan Pack; Fiscal Year: 2003
    ..abstract_text> ..
  50. Biomarkers of Aging in the Bay Area Sleep Cohort
    Donald Bliwise; Fiscal Year: 2005
    ..abstract_text> ..
  51. MECHANICS OF ACUTE LUNG INJURY
    Jason Bates; Fiscal Year: 2009
    ..The results of our studies are expected to lead to the design of physiologically-based lung recruitment strategies that can be tailored to the individual patient with ALI. This will set the stage for future clinical trials. ..
  52. EVALUATION OF DIAGNOSTIC TESTS FOR PEDIATRIC SLEEP APNEA
    Carol Rosen; Fiscal Year: 2004
    ..abstract_text> ..
  53. Effect of leukoreduction on infection risk in trauma
    Avery Nathens; Fiscal Year: 2004
    ..abstract_text> ..
  54. Effects of Opioids on Sleep and Fatigue
    Joel Dimsdale; Fiscal Year: 2004
    ..abstract_text> ..
  55. Research Priorities in Ambulatory Management of Obstructive Sleep Apnea Workshop
    SAMUEL KUNA; Fiscal Year: 2007
    ..We submit that this workshop is an essential ?next step? to ensuring that there is[unreadable] substantive advancement of scientific knowledge in this important field. ..
  56. Polysomnographic Assessment of Alternative Treatment
    Donald Bliwise; Fiscal Year: 2006
    ..abstract_text> ..
  57. Fetal Adaptation of Chronic Uterine Blood Flow Reduction
    David Boyle; Fiscal Year: 2006
    ..These data will be crucial in the design of potential interventions in humans to prevent and/or mitigate fetal growth restriction and its lifelong consequences. ..
  58. Technological Home Care: Improving Caregiving
    Carol Smith; Fiscal Year: 2009
    ..The potential significance and the long term goals are to strengthen home caregiving skills, improve health status, quality of life and self-management of chronic illness symptoms and invasive home care treatment. ..
  59. The Electrophysiology of Motor Neuron Diseases
    Mark Bromberg; Fiscal Year: 2002
    ..Currently, most MUNE techniques rely on proprietary software. We will develop software for use on PC-based computer systems, making them available to all laboratories. ..
  60. Subcortical Hyperintensities in Sleep Apnea Syndrome
    Mark Aloia; Fiscal Year: 2007
    ..We expect to analyze data on approximately 1,120 participants based on our preliminary studies with this data set. [unreadable] [unreadable]..