inbreeding

Summary

Summary: The mating of plants or non-human animals which are closely related genetically.

Top Publications

  1. ncbi R/qtl: QTL mapping in experimental crosses
    Karl W Broman
    Department of Biostatistics, Johns Hopkins University, 615 N Wolfe St, Baltimore, MD 21205, USA
    Bioinformatics 19:889-90. 2003
  2. ncbi The genetic architecture of maize flowering time
    Edward S Buckler
    U S Department of Agriculture USDA Agricultural Research Service USDA ARS, USA
    Science 325:714-8. 2009
  3. ncbi Genetic properties of the maize nested association mapping population
    Michael D McMullen
    United States Department of Agriculture Agriculture Research Service USDA ARS, USA
    Science 325:737-40. 2009
  4. ncbi The genetics of inbreeding depression
    Deborah Charlesworth
    Institute for Evolutionary Biology, Ashworth Laboratories, King s Buildings, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, UK
    Nat Rev Genet 10:783-96. 2009
  5. pmc A Markov chain Monte Carlo approach for joint inference of population structure and inbreeding rates from multilocus genotype data
    Hong Gao
    Department of Biological Statistics and Computational Biology, Cornell University, Ithaca, New York 14853, USA
    Genetics 176:1635-51. 2007
  6. pmc Genetic design and statistical power of nested association mapping in maize
    Jianming Yu
    Institute for Genomic Diversity, Cornell University, Ithaca, New York 14853 2703, USA
    Genetics 178:539-51. 2008
  7. pmc Genetic characterization and linkage disequilibrium estimation of a global maize collection using SNP markers
    Jianbing Yan
    Genetic Resources Program, International Maize and Wheat Improvement Center, Mexico City, Mexico
    PLoS ONE 4:e8451. 2009
  8. ncbi Inbreeding promotes female promiscuity
    Łukasz Michalczyk
    School of Biological Sciences, University of East Anglia, Norwich Research Park, Norwich NR4 7TJ, UK
    Science 333:1739-42. 2011
  9. pmc Male-male competition magnifies inbreeding depression in wild house mice
    S Meagher
    Department of Biology, University of Utah, Salt Lake City, UT 84112, USA
    Proc Natl Acad Sci U S A 97:3324-9. 2000
  10. ncbi Genomic inbreeding and relationships among Holsteins, Jerseys, and Brown Swiss
    P M Vanraden
    Animal Improvement Programs Laboratory, Agricultural Research Service, USDA, Beltsville, MD 20705 2350, USA
    J Dairy Sci 94:5673-82. 2011

Research Grants

Detail Information

Publications373 found, 100 shown here

  1. ncbi R/qtl: QTL mapping in experimental crosses
    Karl W Broman
    Department of Biostatistics, Johns Hopkins University, 615 N Wolfe St, Baltimore, MD 21205, USA
    Bioinformatics 19:889-90. 2003
    ....
  2. ncbi The genetic architecture of maize flowering time
    Edward S Buckler
    U S Department of Agriculture USDA Agricultural Research Service USDA ARS, USA
    Science 325:714-8. 2009
    ..Thus, a simple additive model accurately predicts flowering time for maize, in contrast to the genetic architecture observed in the selfing plant species rice and Arabidopsis...
  3. ncbi Genetic properties of the maize nested association mapping population
    Michael D McMullen
    United States Department of Agriculture Agriculture Research Service USDA ARS, USA
    Science 325:737-40. 2009
    ..This implies that pericentromeric regions may contribute disproportionally to heterosis...
  4. ncbi The genetics of inbreeding depression
    Deborah Charlesworth
    Institute for Evolutionary Biology, Ashworth Laboratories, King s Buildings, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, UK
    Nat Rev Genet 10:783-96. 2009
    b>Inbreeding depression - the reduced survival and fertility of offspring of related individuals - occurs in wild animal and plant populations as well as in humans, indicating that genetic variation in fitness traits exists in natural ..
  5. pmc A Markov chain Monte Carlo approach for joint inference of population structure and inbreeding rates from multilocus genotype data
    Hong Gao
    Department of Biological Statistics and Computational Biology, Cornell University, Ithaca, New York 14853, USA
    Genetics 176:1635-51. 2007
    ..to quantify the contribution of two forms of nonrandom mating to patterns of standing genetic variation: inbreeding (mating among relatives) and population substructure (limited dispersal of gametes)...
  6. pmc Genetic design and statistical power of nested association mapping in maize
    Jianming Yu
    Institute for Genomic Diversity, Cornell University, Ithaca, New York 14853 2703, USA
    Genetics 178:539-51. 2008
    ..By integrating genetic design, natural diversity, and genomics technologies, this new complex trait dissection strategy should greatly facilitate endeavors to link molecular variation with phenotypic variation for various complex traits...
  7. pmc Genetic characterization and linkage disequilibrium estimation of a global maize collection using SNP markers
    Jianbing Yan
    Genetic Resources Program, International Maize and Wheat Improvement Center, Mexico City, Mexico
    PLoS ONE 4:e8451. 2009
    ..A core set of inbreds was defined based on haplotypes, and 60 lines capture 90% of the haplotype diversity of the entire panel. The defined core sets and the entire collection can be used widely for different research targets...
  8. ncbi Inbreeding promotes female promiscuity
    Łukasz Michalczyk
    School of Biological Sciences, University of East Anglia, Norwich Research Park, Norwich NR4 7TJ, UK
    Science 333:1739-42. 2011
    ..the red flour beetle, Tribolium castaneum, we identify major fitness benefits of polyandry to females under inbreeding, when the risks of fertilization by incompatible male haplotypes are especially high...
  9. pmc Male-male competition magnifies inbreeding depression in wild house mice
    S Meagher
    Department of Biology, University of Utah, Salt Lake City, UT 84112, USA
    Proc Natl Acad Sci U S A 97:3324-9. 2000
    The detrimental effects of inbreeding on vertebrates are well documented for early stages of the life cycle in the laboratory...
  10. ncbi Genomic inbreeding and relationships among Holsteins, Jerseys, and Brown Swiss
    P M Vanraden
    Animal Improvement Programs Laboratory, Agricultural Research Service, USDA, Beltsville, MD 20705 2350, USA
    J Dairy Sci 94:5673-82. 2011
    Genomic measures of relationship and inbreeding within and across breeds were compared with pedigree measures using genotypes for 43,385 loci of 25,219 Holsteins, 3,068 Jerseys, and 872 Brown Swiss...
  11. ncbi COANCESTRY: a program for simulating, estimating and analysing relatedness and inbreeding coefficients
    Jinliang Wang
    Institute of Zoology, Zoological Society of London, London NW1 4RY, UK
    Mol Ecol Resour 11:141-5. 2011
    The software package COANCESTRY implements seven relatedness estimators and three inbreeding estimators to estimate relatedness and inbreeding coefficients from multilocus genotype data...
  12. ncbi Reconciling the analysis of IBD and IBS in complex trait studies
    Joseph E Powell
    Queensland Statistical Genetics Laboratory, Queensland Institute of Medical Research, 300 Herston Road, Brisbane, Queensland 4006, Australia
    Nat Rev Genet 11:800-5. 2010
    ..Recognizing this aim leads to better methods to estimating IBD with benefits in mapping genes, estimating genetic variance and predicting inbreeding depression.
  13. ncbi The genetic basis of inbreeding depression
    B Charlesworth
    Institute of Cell, Animal and Population Biology, University of Edinburgh, UK
    Genet Res 74:329-40. 1999
    Data on the effects of inbreeding on fitness components are reviewed in the light of population genetic models of the possible genetic causes of inbreeding depression...
  14. ncbi A quantitative review of heterozygosity-fitness correlations in animal populations
    J R Chapman
    Edward Grey Institute, Department of Zoology, University of Oxford, Oxford OX1 3PS, UK
    Mol Ecol 18:2746-65. 2009
    ..powerful at detecting relationships than multilocus heterozygosity, and populations predicted to have elevated inbreeding variance did not exhibit higher mean effect sizes...
  15. ncbi Genetic compatibility, mate choice and patterns of parentage: invited review
    T Tregenza
    Ecology and Evolution Group, School of Biology, University of Leeds, UK
    Mol Ecol 9:1013-27. 2000
    ..There are also numerous cases of inbreeding avoidance, but little evidence that mate choice or differential fertilization success driven by genetic ..
  16. pmc Cis-transcriptional variation in maize inbred lines B73 and Mo17 leads to additive expression patterns in the F1 hybrid
    Robert M Stupar
    Center for Plant and Microbial Genomics, Department of Plant Biology, University of Minnesota, Saint Paul, Minnesota 55108, USA
    Genetics 173:2199-210. 2006
    ..Collectively, our data suggest that allelic cis-regulatory variation between B73 and Mo17 dictates maintenance of inbred allelic expression levels in the F1 hybrid, resulting in additive expression patterns...
  17. ncbi Genetic diversity, inbreeding and breeding practices in dogs: results from pedigree analyses
    Grégoire Leroy
    AgroParisTech, UMR 1313, Génétique Animale et Biologie Intégrative, F 75000 Paris, France
    Vet J 189:177-82. 2011
    ..management in closed populations and historical bottlenecks, many dog breeds have experienced considerable inbreeding and show (on the basis of a pedigree approach) comparable diversity loss compared to other domestic species...
  18. ncbi The extent of linkage disequilibrium in Arabidopsis thaliana
    Magnus Nordborg
    Department of Biological Sciences, University of Southern California, Los Angeles, California 90089, USA
    Nat Genet 30:190-3. 2002
    ..The combination of a relatively high level of polymorphism and extensive haplotype structure bodes well for developing a genome-wide LD map in A. thaliana...
  19. pmc Runs of homozygosity and population history in cattle
    Deirdre C Purfield
    Smurfit Institute of Genetics, University of Dublin, Trinity College, Dublin 2, Ireland
    BMC Genet 13:70. 2012
    ..n = 777,962) bi-allelic SNPs in a range of cattle breed samples to correlate ROH with the pedigree-based inbreeding coefficients and to validate subsequent analyses using 54,001 SNP genotypes...
  20. pmc Patterns of inbreeding depression and architecture of the load in subdivided populations
    Sylvain Glemin
    Institut National de la Recherche Agronomique SGAP Montpellier, F 34130 Mauguio, France
    Genetics 165:2193-212. 2003
    b>Inbreeding depression is a general phenomenon that is due mainly to recessive deleterious mutations, the so-called mutation load. It has been much studied theoretically...
  21. pmc Compromised stability of DNA methylation and transposon immobilization in mosaic Arabidopsis epigenomes
    Jon Reinders
    Department of Plant Biology, University of Geneva, Sciences III, Geneva, Switzerland
    Genes Dev 23:939-50. 2009
    ..Although analysis after eight generations of inbreeding, supported by genome-wide DNA methylation profiling, identified recombined parental chromosomal segments, these ..
  22. ncbi Genetic control of rice plant architecture under domestication
    Jian Jin
    National Key Laboratory of Plant Molecular Genetics, Shanghai Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 300 Fenglin Road, Shanghai 200032, China
    Nat Genet 40:1365-9. 2008
    ..Rice transformation experiments demonstrate that artificial selection of an amino acid substitution in the PROG1 protein during domestication led to the transition from the plant architecture of wild rice to that of domesticated rice...
  23. pmc Mutation load and rapid adaptation favour outcrossing over self-fertilization
    Levi T Morran
    Center for Ecology and Evolutionary Biology, 5289 University of Oregon, Eugene, Oregon 97403 5289, USA
    Nature 462:350-2. 2009
    ..for the widespread prevalence of outcrossing in nature despite this inherent disadvantage are the avoidance of inbreeding depression generated by selfing and the ability of outcrossing populations to adapt more rapidly to ..
  24. ncbi Perspective: purging the genetic load: a review of the experimental evidence
    Peter Crnokrak
    Department of Botany, University of Toronto, 25 Willcocks Street, Toronto, Ontario, M5S 3B2, Canada
    Evolution 56:2347-58. 2002
    b>Inbreeding depression, the reduction in fitness that accompanies inbreeding, is one of the most important topics of research in evolutionary and conservation genetics...
  25. pmc Extreme population-dependent linkage disequilibrium detected in an inbreeding plant species, Hordeum vulgare
    Katherine S Caldwell
    Scottish Crop Research Institute, Invergowrie, Dundee, Scotland
    Genetics 172:557-67. 2006
    ..Here we report a detailed study of localized LD in different populations of an inbreeding crop species...
  26. pmc Parentage and sibship inference from multilocus genotype data under polygamy
    J Wang
    Institute of Zoology, Zoological Society of London, London NW1 4RY, United Kingdom
    Genetics 181:1579-94. 2009
    ..It is little affected by inbreeding in parents and is moderately robust to nonrandom mating and linkage of markers...
  27. pmc Quantification of inbreeding due to distant ancestors and its detection using dense single nucleotide polymorphism data
    Matthew C Keller
    Department of Psychology and Neuroscience, Institute for Behavioral Genetics, University of Colorado, Boulder, CO 80309, USA
    Genetics 189:237-49. 2011
    b>Inbreeding depression, which refers to reduced fitness among offspring of related parents, has traditionally been studied using pedigrees...
  28. ncbi Inbreeding depression is purged in the invasive insect Harmonia axyridis
    Benoit Facon
    Institut National pour la Recherche Agronomique, UMR Centre de Biologie pour la Gestion des Populations, Campus International de Baillarguet, Montferrier Lez Cedex, France
    Curr Biol 21:424-7. 2011
    Bottlenecks in population size reduce genetic diversity and increase inbreeding, which can lead to inbreeding depression...
  29. pmc Genomic confirmation of hybridisation and recent inbreeding in a vector-isolated Leishmania population
    Matthew B Rogers
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, United Kingdom Centre for Immunology and Infection, Department of Biology, University of York, York, United Kingdom
    PLoS Genet 10:e1004092. 2014
    ..This observation allowed us to estimate the relative rates of sexual and asexual reproduction within this population, to our knowledge the first quantitative estimate of these events during the Leishmania life cycle. ..
  30. pmc High-density linkage mapping in a pine tree reveals a genomic region associated with inbreeding depression and provides clues to the extent and distribution of meiotic recombination
    Emilie Chancerel
    INRA, UMR1202 BIOGECO, F 33610 Cestas, France
    BMC Biol 11:50. 2013
    ..Such approaches are particularly useful in species with a large genome size, precluding the use of whole-genome shotgun assembly with current technologies...
  31. ncbi Inbreeding depression in benign and stressful environments
    P Armbruster
    Department of Biology, Reiss Science Bldg 406, Georgetown University, 37th and O Streets NW, Washington, DC 20057 1229, USA
    Heredity (Edinb) 95:235-42. 2005
    Understanding the consequences of inbreeding has important implications for a wide variety of topics in population biology...
  32. ncbi Fine-scale population structure, inbreeding risk and avoidance in a wild insect population
    Amanda Bretman
    Centre for Ecology and Conservation, School of Biosciences, University of Exeter, Cornwall Campus, Penryn TR10 9EZ, UK
    Mol Ecol 20:3045-55. 2011
    ..insects tend to have such large- and high-density populations and are so mobile that they are unlikely to face inbreeding risks through fine-scale population structuring...
  33. pmc Genomic selection requires genomic control of inbreeding
    Anna K Sonesson
    Nofima AS, 1431 As, Norway
    Genet Sel Evol 44:27. 2012
    In the past, pedigree relationships were used to control and monitor inbreeding because genomic relationships among selection candidates were not available until recently...
  34. pmc A comparison of approaches to estimate the inbreeding coefficient and pairwise relatedness using genomic and pedigree data in a sheep population
    Meng Hua Li
    Biotechnology and Food Research, MTT Agrifood Research Finland, Jokioinen, Finland
    PLoS ONE 6:e26256. 2011
    Genome-wide SNP data provide a powerful tool to estimate pairwise relatedness among individuals and individual inbreeding coefficient...
  35. ncbi Control of a key transition from prostrate to erect growth in rice domestication
    Lubin Tan
    State Key Laboratory of Plant Physiology and Biochemistry, National Center for Evaluation of Agricultural Wild Plants Rice, Department of Plant Genetics and Breeding, China Agricultural University, Beijing, 100094, China
    Nat Genet 40:1360-4. 2008
    ..Sequence comparison shows that 182 varieties of cultivated rice, including 87 indica and 95 japonica cultivars from 17 countries, carry identical mutations in the prog1 coding region that may have become fixed during rice domestication...
  36. ncbi Simultaneous estimation of null alleles and inbreeding coefficients
    Igor J Chybicki
    The Department of Genetics, Institute of Experimental Biology, Kazimierz Wielki University, Bydgoszcz 85 064, Poland
    J Hered 100:106-13. 2009
    ..produce "null" alleles, which, when present in high proportion, may affect estimates of key parameters such as inbreeding and relatedness coefficients or measures of genetic differentiation...
  37. ncbi Place and matching-to-place spatial learning affected by rat inbreeding (Dark-Agouti, Fischer 344) and albinism (Wistar, Sprague-Dawley) but not domestication (wild rat vs. Long-Evans, Fischer-Norway)
    K Troy Harker
    Canadian Center for Behavioral Neuroscience, University of Lethbridge, 4401 University Drive, Lethbridge, Alta, Canada
    Behav Brain Res 134:467-77. 2002
    ..In general, although nonspatial and spatial deficits were associated with both inbreeding and albinism, impaired spatial performance is not a necessary result of domestication.
  38. ncbi Between a rock and a hard place: evaluating the relative risks of inbreeding and outbreeding for conservation and management
    Suzanne Edmands
    Department of Biological Sciences, AHF 107, University of Southern California, Los Angeles, CA 90089 0371, USA
    Mol Ecol 16:463-75. 2007
    ..managers are often faced with the dilemma that intentional hybridization might save a population from inbreeding depression but it might also induce outbreeding depression...
  39. pmc Testing strategies for genomic selection in aquaculture breeding programs
    Anna K Sonesson
    Nofima Marine AS, As, Norway
    Genet Sel Evol 41:37. 2009
    ..The aim of this paper was to investigate genetic gains, inbreeding and the accuracy of selection in a general genomic selection scheme for aquaculture, where the test population ..
  40. pmc Population structure and inbreeding from pedigree analysis of purebred dogs
    Federico C F Calboli
    Department of Epidemiology and Public Health, Imperial College, London W2 1PG, United Kingdom
    Genetics 179:593-601. 2008
    ..The choice of breeds for such studies should be informed by a knowledge of factors such as inbreeding, genetic diversity, and population structure, which are likely to depend on breed-specific selective breeding ..
  41. pmc Partial short-read sequencing of a highly inbred Iberian pig and genomics inference thereof
    A Esteve-Codina
    Departament de Ciencia Animal i dels Aliments, Facultat de Veterinaria, Universitat Autonoma de Barcelona, Bellaterra, Spain
    Heredity (Edinb) 107:256-64. 2011
    ..Further, a genome wide Hudson-Kreitman-Aguadé test was carried out per window; overall, variability was in agreement with neutral expectations...
  42. ncbi Breeding systems and genome evolution
    D Charlesworth
    Institute of Cell, Animal and Population Biology, University of Edinburgh, Ashworth Laboratory, King s Buildings, West Mains Road, Edinburgh EH9 3JT, UK
    Curr Opin Genet Dev 11:685-90. 2001
    The profound effects of inbreeding and other non-recombining breeding systems on genetic variability and molecular evolution are now beginning to be understood...
  43. pmc Mutual mate choice: when it pays both sexes to avoid inbreeding
    Mathieu Lihoreau
    UMR 6552 Ethos, CNRS Universite de Rennes 1, Campus Beaulieu, Rennes, France
    PLoS ONE 3:e3365. 2008
    ..However, empirical evidence testing and validating this prediction is scarce. In particular, whereas inbreeding avoidance is expected to induce sexual conflicts, in some cases both partners could benefit by acting in concert ..
  44. pmc Levels of DNA polymorphism vary with mating system in the nematode genus caenorhabditis
    Andrew Graustein
    Department of Biology, Bowdoin College, Brunswick, Maine 04011, USA
    Genetics 161:99-107. 2002
    ..remanei. We argue that either population bottlenecks or the repeated action of natural selection, coupled with high levels of selfing, are likely to explain the observed reductions in species-wide genetic diversity...
  45. ncbi Selection at linked sites in the partial selfer Caenorhabditis elegans
    Asher D Cutter
    Department of Ecology and Evolutionary Biology, University of Arizona, USA
    Mol Biol Evol 20:665-73. 2003
    ..Clarification of the relative roles of genetic hitchhiking and background selection in C. elegans awaits the development of specific theoretical predictions that account for partial self-fertilization and biased sex ratios...
  46. ncbi Research on inbreeding in the 'omic' era
    Torsten N Kristensen
    Department of Genetics and Biotechnology, Aarhus University, Blichers alle 20, DK 8830 Tjele, Denmark
    Trends Ecol Evol 25:44-52. 2010
    Developments in molecular and systems biology have enabled novel approaches to be used in the study of inbreeding. Mechanistic and functional studies using 'omic' technologies can increase the understanding of the consequences of ..
  47. ncbi Inbreeding in genome-wide selection
    H D Daetwyler
    Genetics and Genomics, Roslin Institute Edinburgh, Roslin, Midlothian, UK
    J Anim Breed Genet 124:369-76. 2007
    ..which increased genetic gain by increasing accuracy of evaluation have also led to an increased rate of inbreeding per generation (DeltaFG)...
  48. ncbi Paternal kin discrimination: the evidence and likely mechanisms
    Anja Widdig
    Max Planck Institute for Evolutionary Anthropology, Department of Primatology, Deutscher Platz 6, D 04103 Leipzig, Germany
    Biol Rev Camb Philos Soc 82:319-34. 2007
    ..Finally, I discuss the possible cues used in paternal kin discrimination and offer suggestions for future studies...
  49. ncbi Rise and fall of a wolf population: genetic diversity and structure during recovery, rapid expansion and drastic decline
    E Jansson
    Department of Biology, University of Oulu, Oulu, FIN 90014, Finland
    Mol Ecol 21:5178-93. 2012
    ..643, P = 0.021) despite population expansion, likely a result of an increase in inbreeding (F(IS)  = 0...
  50. ncbi Does long-distance pollen dispersal preclude inbreeding in tropical trees? Fragmentation genetics of Dysoxylum malabaricum in an agro-forest landscape
    S A Ismail
    Ecosystem Management, Department of Environmental Systems Science, ETH Zurich, Universitatsstrasse 16, CH 8092 Zurich, Switzerland
    Mol Ecol 21:5484-96. 2012
    ..We discuss the processes leading to the observed patterns of pollen dispersal and the implications of this for conservation management of D. malabaricum and tropical trees more generally...
  51. pmc Visual kin recognition in nonhuman primates: (Pan troglodytes and Macaca mulatta): inbreeding avoidance or male distinctiveness?
    Lisa A Parr
    Division of Psychiatry and Behavioral Sciences andYerkes National Primate Research Center, Emory University, 954 Gatewood Rd, Atlanta, GA 30329, USA
    J Comp Psychol 124:343-50. 2010
    ..This was interpreted as an inbreeding avoidance mechanism where females, the dispersing gender, should avoid mating with any male that resembles their ..
  52. ncbi Prediction of hybrid performance in maize using molecular markers and joint analyses of hybrids and parental inbreds
    Tobias A Schrag
    Institute of Plant Breeding, Seed Science and Population Genetics, University of Hohenheim, 70593 Stuttgart, Germany
    Theor Appl Genet 120:451-61. 2010
    ..The additional modifications of the marker-based approaches had no clear effect. Our study showed the high potential of joint analyses of hybrids and parental inbred lines for the prediction of performance of untested hybrids...
  53. ncbi Farm-by-farm analysis of microsatellite, mtDNA and SNP genotype data reveals inbreeding and crossbreeding as threats to the survival of a native Spanish pig breed
    J M Herrero-Medrano
    Departamento de Produccion Animal, Fac de Veterinària, Universidad de Murcia, área de Genética C P 30100, Murcia, Spain
    Anim Genet 44:259-66. 2013
    ..53). However, when the eight farms that rear at least 10 CM pigs were independently analyzed, high levels of inbreeding were found in some...
  54. ncbi Direct genetic evidence for reproductive philopatry and associated fine-scale migrations in female blacktip reef sharks (Carcharhinus melanopterus) in French Polynesia
    Johann Mourier
    Laboratoire d Excellence CORAIL, USR 3278 CNRS EPHE, CRIOBE, BP 1013, 98729, Moorea, French Polynesia
    Mol Ecol 22:201-14. 2013
    ..Many offspring showed a high level of inbreeding indicating an overall reduced population size, restricted movements and dispersal, or specific mating behaviour...
  55. pmc Fixation, segregation and linkage of allozyme loci in inbred families of the Pacific oyster Crassostrea gigas (Thunberg): implications for the causes of inbreeding depression
    D J McGoldrick
    Bodega Marine Laboratory, University of California, Davis, Bodega Bay 94923, USA
    Genetics 146:321-34. 1997
    The effect that inbreeding has on the fixation and segregation of genes has rarely been confirmed by direct observation...
  56. pmc The genome sequencing of an albino Western lowland gorilla reveals inbreeding in the wild
    Javier Prado-Martinez
    Institut de Biologia Evolutiva, CSIC Universitat Pompeu Fabra, PRBB, Barcelona 08003, Spain
    BMC Genomics 14:363. 2013
    ..Here, we study the genetic cause of his albinism and making use of whole genome sequencing data we find a higher inbreeding coefficient compared to other gorillas.
  57. ncbi Inbreeding depression due to mildly deleterious mutations in finite populations: size does matter
    T Bataillon
    INRA SGAP, Domaine de Melgueil, Mauguio, France
    Genet Res 75:75-81. 2000
    We studied the effects of population size on the inbreeding depression and genetic load caused by deleterious mutations at a single locus...
  58. ncbi Partial resistance of Medicago truncatula to Aphanomyces euteiches is associated with protection of the root stele and is controlled by a major QTL rich in proteasome-related genes
    Naceur Djébali
    Université de Toulose, Toulose, France
    Mol Plant Microbe Interact 22:1043-55. 2009
    ..Most of these genes were shown to be induced only in inoculated A17. Novel mechanisms possibly involved in the observed partial resistance are proposed...
  59. ncbi Experimental infection magnifies inbreeding depression in house mice
    P Ilmonen
    Department of Biology, University of Utah, Salt Lake City, UT, USA
    J Evol Biol 21:834-41. 2008
    It is often assumed that inbreeding reduces resistance to pathogens, yet there are few experimental tests of this idea in vertebrates, and no tests for the effects of moderate levels of inbreeding more commonly found in nature...
  60. ncbi Proteomic characterization of a temperature-sensitive conditional lethal in Drosophila melanogaster
    K S Pedersen
    Department of Biological Sciences, Aarhus University, Aarhus C, Denmark
    Heredity (Edinb) 104:125-34. 2010
    ..that is expressed only under specific environmental conditions can contribute to additional adverse effects of inbreeding if environmental conditions change...
  61. ncbi Mapping of quantitative trait loci for high level of self-incompatibility in Brassica rapa L
    Katsunori Hatakeyama
    National Institute of Vegetable and Tea Science NIVTS, 360, Kusawa, Ano, Tsu, Mie 514 2392, Japan
    Genome 53:257-65. 2010
    ..This is the first report of QTL for high-level SI evaluated under insect pollination in a Brassica vegetable. Our results could be useful for the marker-assisted selection of parental lines with a stable SI...
  62. ncbi Genetic variation in Arabidopsis thaliana for night-time leaf conductance
    Mairgareth A Christman
    Department of Land, Air and Water Resources, University of California, Davis, CA 95616, USA
    Plant Cell Environ 31:1170-8. 2008
    ..Further characterization of genetic variation in g(night) within and among populations and species, and of associations with other traits and native habitats will be needed to understand g(night) as a putatively adaptive trait...
  63. ncbi Heterozygosity and survival in blue tits (Cyanistes caeruleus): contrasting effects of presumably functional and neutral loci
    Juanita Olano-Marin
    Department of Behavioral Ecology and Evolutionary Genetics, Max Planck Institute for Ornithology, D 82319 Starnberg Seewiesen, Germany
    Mol Ecol 20:4028-41. 2011
    ..General effects caused by inbreeding and/or local effects at single loci have been used as explanations of HFC, but the debate about the causes of ..
  64. ncbi Genetic diversity, population structure, effective population size and demographic history of the Finnish wolf population
    J Aspi
    Department of Biology, University of Oulu, Finland
    Mol Ecol 15:1561-76. 2006
    ..This may be caused by increased inbreeding, diminished dispersal within the population, and decreased immigration to the population during the last study ..
  65. ncbi Heterozygosity-fitness correlations in a migratory bird: an analysis of inbreeding and single-locus effects
    Xavier A Harrison
    Centre for Ecology and Conservation, University of Exeter, Tremough Campus, Penryn, Cornwall TR10 9EZ, UK
    Mol Ecol 20:4786-95. 2011
    ..have described a correlation between heterozygosity and fitness and usually conclude that this is evidence for inbreeding depression...
  66. ncbi Correlations between heterozygosity and reproductive success in the blue tit (Cyanistes caeruleus): an analysis of inbreeding and single locus effects
    Juanita Olano-Marin
    Department of Behavioral Ecology and Evolutionary Genetics, Max Planck Institute for Ornithology, Starnberg Seewiesen, Germany
    Evolution 65:3175-94. 2011
    ..is necessary to employ large numbers of markers with known function and independently estimate the variation in inbreeding in the population...
  67. ncbi Using three overlapped RILs to dissect genetically clustered QTL for fiber strength on Chro.D8 in Upland cotton
    Hong Chen
    National Key Laboratory of Crop Genetics and Germplasm Enhancement, Nanjing Agricultural University, 210095, Nanjing, Jiangsu Province, China
    Theor Appl Genet 119:605-12. 2009
    ..8) on Chro.D8 for fiber strength following analysis of three RIL backcrossed F(2)/F(2:3) progenies at JES/NAU and BES/XJ over 2 years. Five QTL for fiber strength exhibited a total phenotypic variance (PV) of 28.8-59.6%...
  68. ncbi Genetic variability in Hanoverian warmblood horses using pedigree analysis
    H Hamann
    Institute for Animal Breeding and Genetics, University of Veterinary Medicine Hannover, Bunteweg 17p, 30559 Hannover, Germany
    J Anim Sci 86:1503-13. 2008
    ..total of 310,109 Hanoverian warmblood horses was analyzed to ascertain the genetic variability, coefficients of inbreeding, and gene contributions of foreign populations...
  69. pmc Orthologous genes identified by transcriptome sequencing in the spider genus Stegodyphus
    Tiina M Mattila
    Department of Biology, University of Oulu, Finland
    BMC Genomics 13:70. 2012
    The evolution of sociality in spiders involves a transition from an outcrossing to a highly inbreeding mating system, a shift to a female biased sex ratio, and an increase in the reproductive skew among individuals...
  70. pmc An analysis of genetic diversity and inbreeding in Wuchereria bancrofti: implications for the spread and detection of drug resistance
    Thomas S Churcher
    Department of Infectious Disease Epidemiology, St Mary s Campus, Imperial College London, London, United Kingdom
    PLoS Negl Trop Dis 2:e211. 2008
    ..Helminth genetic differentiation between hosts and non-random mating will also increase the number of hosts (and the number of samples per host) that need to be genotyped, and could enhance the rate of spread of anthelmintic resistance...
  71. pmc Reduced inbreeding depression after species range expansion
    Benoit Pujol
    Department of Plant Sciences, University of Oxford, South Parks Road, Oxford OX1 3RB, United Kingdom
    Proc Natl Acad Sci U S A 106:15379-83. 2009
    ..Here, we show that range expansion also strongly depletes inbreeding depression...
  72. ncbi Sex-biased natal dispersal and inbreeding avoidance in American black bears as revealed by spatial genetic analyses
    Cecily M Costello
    Hornocker Wildlife Institute and Wildlife Conservation Society, 301 N Wilson Avenue, Bozeman, MT 59715, USA
    Mol Ecol 17:4713-23. 2008
    We tested the hypothesis that sex-biased natal dispersal reduces close inbreeding in American black bears, a solitary species that exhibits nearly complete male dispersal and female philopatry...
  73. ncbi Genotype x environment interaction for male attractiveness in an acoustic moth: evidence for plasticity and canalization
    A M Danielson-François
    Department of Ecology and Evolutionary Biology, University of Kansas, Lawrence, KS, USA
    J Evol Biol 19:532-42. 2006
    ..We argue that variation persists in natural populations because G x E interactions prevent any one variant from producing the optimal phenotype across all environments...
  74. ncbi Promiscuous females avoid inbreeding by controlling sperm storage
    Amanda Bretman
    Centre for Ecology and Conservation, University of Exeter, Cornwall Campus, Penryn, UK
    Mol Ecol 18:3340-5. 2009
    ..Paternity is almost completely predicted by how much sperm from a particular male is stored, and unrelated males contribute more sperm to storage and have a corresponding higher paternity success...
  75. pmc An integrative approach to genomic introgression mapping
    Andrew J Severin
    Department of Agronomy, Iowa State University, Ames, Iowa 50011, USA
    Plant Physiol 154:3-12. 2010
    ..We conclude that the comparative RNA-Seq approach can be optimized with sufficient sampling and by utilizing a post hoc correction accounting for gene density variation that controls for false discoveries...
  76. pmc B73-Mo17 near-isogenic lines demonstrate dispersed structural variation in maize
    Steven R Eichten
    Department of Plant Biology, University of Minnesota, Saint Paul, Minnesota 55108, USA
    Plant Physiol 156:1679-90. 2011
    ..The utility of this population for the discovery and validation of quantitative trait loci was assessed through analysis of plant height variation...
  77. ncbi Correlated inbreeding among relatives: occurrence, magnitude, and implications
    Jane M Reid
    Institute of Biological and Environmental Sciences, School of Biological Sciences, Zoology Building, Tillydrone Avenue, University of Aberdeen, Aberdeen AB24 2TZ, United Kingdom
    Evolution 64:973-85. 2010
    ..Contrary to basic expectation, individual coefficients of inbreeding (f) were recently hypothesized to be intrinsically correlated across parents and offspring in structured ..
  78. pmc Quantitative epigenetics through epigenomic perturbation of isogenic lines
    Frank Johannes
    University of Groningen, Nijenborgh 7, AG Groningen, The Netherlands
    Genetics 188:215-27. 2011
    ....
  79. ncbi Molecular, morphological, and cytological analysis of diverse Brachypodium distachyon inbred lines
    E Filiz
    Sabanci University, Biological Science and Bioengineering Program, 34956, Tuzla, Istanbul, Turkey
    Genome 52:876-90. 2009
    ..These results will also help efforts to have a better understanding of complex large genomes (i.e., wheat, barley, and switchgrass)...
  80. ncbi Indel-associated mutation rate varies with mating system in flowering plants
    Jesse D Hollister
    Department of Ecology and Evolutionary Biology, University of California, Irvine, USA
    Mol Biol Evol 27:409-16. 2010
    ..sativa, and the weakest effect in the relatively ancient selfer A. thaliana. These results support the novel idea that differences in life history, such as the level of selfing, can affect the per-individual mutation rate among species...
  81. ncbi Fine-scale genetic structure in a free-living ungulate population
    D W Coltman
    Department of Animal and Plant Sciences, University of Sheffield, Western Bank, UK
    Mol Ecol 12:733-42. 2003
    ..in quantitative genetic and allelic association studies, as well as having implications for population dynamics, inbreeding and kin selection...
  82. pmc Detection of quantitative trait loci for growth and fatness in pigs
    J P Bidanel
    Institut National de la Recherche Agronomique, Station de Génétique Quantitative et Appliquée, 78352 Jouy en Josas Cedex, France
    Genet Sel Evol 33:289-309. 2001
    ..LW alleles were associated with high growth rate and low backfat thickness, except for those of chromosome 7 and to a lesser extent early-growth alleles on chromosomes 1 and 2 and backfat thickness alleles on chromosome 6...
  83. ncbi The cost of inbreeding in Arabidopsis
    Carlos D Bustamante
    Department of Organismic and Evolutionary Biology, Harvard University, 16 Divinity Avenue, Cambridge, Massachusetts 02138, USA
    Nature 416:531-4. 2002
    ..self-fertilization, which corroborates a prediction of population genetics theory that species with a high frequency of inbreeding are less efficient in eliminating deleterious mutations owing to their reduced effective population size.
  84. ncbi Genetic analysis identifies quantitative trait loci controlling rosette mineral concentrations in Arabidopsis thaliana under drought
    Artak Ghandilyan
    Laboratory of Genetics, Wageningen University, NL 6703 BD Wageningen, The Netherlands
    New Phytol 184:180-92. 2009
    ..The low number of common mineral concentration QTLs, shared among different RIL populations, tissues and conditions in Arabidopsis, suggests that breeding for robust, mineral biofortified crops will be complex...
  85. ncbi Dynamics of inbreeding depression due to deleterious mutations in small populations: mutation parameters and inbreeding rate
    J Wang
    Institute of Cell, Animal and Population Biology, University of Edinburgh, Scotland, UK
    Genet Res 74:165-78. 1999
    ..The results show that inbreeding depression and the number of lethal equivalents due to partially recessive mutations can be partly purged from ..
  86. pmc Pedigree analysis of eight Spanish beef cattle breeds
    Juan Pablo Gutierrez
    Departamento de Produccion Animal, Facultad de Veterinaria, Universidad Complutense de Madrid, 28040 Madrid, Spain
    Genet Sel Evol 35:43-63. 2003
    ..8. Inbreeding effective population sizes were actually small (21 to 127), especially in the mountain-type breeds...
  87. ncbi High genetic diversity and no inbreeding in the endangered copper redhorse, Moxostoma hubbsi (Catostomidae, Pisces): the positive sides of a long generation time
    Catherine Lippé
    Québec Océan, Departement de Biologie, Universite Laval, Sainte Foy, Quebec, Canada G1K 7P4
    Mol Ecol 15:1769-80. 2006
    ..Overall, these observations corroborate other recent empirical studies confirming that long generation times may act as a buffering effect contributing to a reduction in the pace of genetic diversity erosion in threatened species...
  88. pmc Mixed mating system in the fern Asplenium scolopendrium: implications for colonization potential
    E R Jasper Wubs
    Ecology and Biodiversity Group, Institute of Environmental Biology, Utrecht University, Padualaan 8, Utrecht, The Netherlands
    Ann Bot 106:583-90. 2010
    ..Here, the mating system of Asplenium scolopendrium, a diploid homosporous fern species, is examined in relation to colonization processes...
  89. ncbi Rates of inbreeding and genetic diversity in Canadian Holstein and Jersey cattle
    K Stachowicz
    Centre for Genetic Improvement of Livestock, Department of Animal and Poultry Science, University of Guelph, Guelph, Ontario, Canada N1G 2W1
    J Dairy Sci 94:5160-75. 2011
    The accumulation of inbreeding and the loss of genetic diversity is a potential problem in the modern dairy cattle breeds...
  90. ncbi Inbreeding in the Seychelles warbler: environment-dependent maternal effects
    David S Richardson
    Centre for Ecology, Evolution and Conservation, School of Biological Sciences, University of East Anglia, Norwich NR4 7TJ, United Kingdom
    Evolution 58:2037-48. 2004
    The deleterious effects of inbreeding can be substantial in wild populations and mechanisms to avoid such matings have evolved in many organisms...
  91. ncbi Estimation of parameters of inbreeding and genetic drift in populations with overlapping generations
    Jinliang Wang
    Institute of Zoology, Zoological Society of London, Regent s Park, London NW1 4RY, United Kingdom
    Evolution 64:1704-18. 2010
    ..Data from wild populations of baboons and hihi (stitchbird) were analyzed by EPA to demonstrate the use of the estimator in practical sampling and genotyping situations...
  92. ncbi Female-biased dispersal alone can reduce the occurrence of inbreeding in black grouse (Tetrao tetrix)
    C Lebigre
    School of Biological Sciences, University of Aberdeen, Tillydrone Avenue, Aberdeen, AB24 2TZ, UK
    Mol Ecol 19:1929-39. 2010
    Although inbreeding depression and mechanisms for kin recognition have been described in natural bird populations, inbreeding avoidance through mate choice has rarely been reported suggesting that sex-biased dispersal is the main ..
  93. ncbi Evolution of the genetic variability of eight French dairy cattle breeds assessed by pedigree analysis
    C Danchin-Burge
    AgroParisTech, UMR 1313 Génétique Animale et Biologie Intégrative, 16 rue Claude Bernard, Paris, France
    J Anim Breed Genet 129:206-17. 2012
    ..It shows the need for setting up cryobanks as gene reservoirs as well as sustainable breeding programmes that include loss of genetic diversity as an integrated control parameter...
  94. ncbi Inbreeding trends and pedigree analysis of Irish dairy and beef cattle populations
    S Mc Parland
    Teagasc, Moorepark Dairy Production Research Centre, Fermoy, Co Cork, Ireland
    J Anim Sci 85:322-31. 2007
    The objective of this study was to determine the inbreeding levels and to analyze the pedigree of Irish purebred populations of Charolais, Limousin, Hereford, Angus, and Simmental beef cattle, as well as the Holstein-Friesian dairy breed...
  95. ncbi A spatial genetic structure and effects of relatedness on mate choice in a wild bird population
    K Foerster
    Max Planck Institute for Ornithology, Department of Behavioural Ecology and Evolutionary Genetics, PO Box 1564, D 82305 Starnberg Seewiesen, Germany
    Mol Ecol 15:4555-67. 2006
    b>Inbreeding depression, as commonly found in natural populations, should favour the evolution of inbreeding avoidance mechanisms...
  96. ncbi Effects of stress and phenotypic variation on inbreeding depression in Brassica rapa
    Donald M Waller
    Department of Botany, University of Wisconsin Madison, 430 Lincoln Drive, Madison, Wisconsin 53706, USA
    Evolution 62:917-31. 2008
    Stressful environments are often said to increase the expression of inbreeding depression...
  97. ncbi Inbreeding coefficients and coalescence times
    M Slatkin
    Department of Integrative Biology, University of California, Berkeley 94720
    Genet Res 58:167-75. 1991
    ..relationship between coalescence times and identity probabilities, it is possible to extend existing results for inbreeding coefficients in regular systems of mating to find the distribution of coalescence times and the mean coalescence ..
  98. ncbi Impact of nonadditive genetic effects in the estimation of breeding values for fertility and correlated traits
    E Wall
    Sustainable Livestock Systems Group, Scottish Agricultural College, Bush Estate, Penicuik, Midlothian, EH26 0PH, United Kingdom
    J Dairy Sci 88:376-85. 2005
    The effects of inbreeding, heterosis, recombination loss, and percentage Holstein on the estimation of predicted transmitting abilities for fertility traits (calving interval, number of days from calving to first insemination, nonreturn ..
  99. ncbi Inbreeding and advertisement calling in the cricket Teleogryllus commodus: laboratory and field experiments
    Jean M Drayton
    Evolution, Ecology and Genetics, Research School of Biology, The Australian National University, Canberra, ACT, Australia
    Evolution 64:3069-83. 2010
    ..traits reveal a male's heterozygosity or condition to females, then such traits should exhibit declines with inbreeding. We tested this by examining the effect of inbreeding on advertisement calling in male crickets Teleogryllus ..
  100. pmc An inbreeding model of associative overdominance during a population bottleneck
    N Bierne
    Laboratoire Genome, Populations, Interactions, Station Mediterraneenne de l Environnement Littoral, 34200 Sète, France
    Genetics 155:1981-90. 2000
    ..In the present study, associative overdominance is related to the distribution of individual inbreeding levels (i.e., genomic autozygosity)...
  101. pmc Spawning, copulation and inbreeding coefficients in marine invertebrates
    J A Addison
    Department of Biology, Dalhousie University, Halifax, Nova Scotia, Canada B3H 4J1
    Biol Lett 1:450-3. 2005
    ..marine invertebrate life histories and deviation from Hardy-Weinberg equilibrium (non-zero values of FIS, the inbreeding coefficient)...

Research Grants62

  1. Monogonont Rotifers as a Model to Investigate the Biology of Aging
    Terry W Snell; Fiscal Year: 2013
    ..of clonal cultures, so that experiments can take place in the same genetic background, without the potential inbreeding depression imposed on isogenic lines;3) sexual and asexual reproduction in the same genetic background;4) ..
  2. Hypercalciuria and Bone Quality in the Genetic Hypercalciuric Stone-Forming Rats
    David A Bushinsky; Fiscal Year: 2013
    ..Through >90 generations of successive inbreeding we established a strain of rats that now consistently excrete ~8-10 times as much urinary Ca as controls...
  3. Development of normal and dystrophic canine iPS lines
    COLIN EDWARD BISHOP; Fiscal Year: 2010
    ..diseases occur in dogs mainly due to founder effects and population bottlenecks resulting from centuries-old inbreeding practices...
  4. ESTABLISHMENT OF A SPF RHESUS MACAQUE COLONY
    LARRY BILL CUMMINS; Fiscal Year: 2011
    ..to establish this database, will be used to establish and verify pedigree information, manage breeding to avoid inbreeding and maintain genetic variability, while focusing on the primary goal of maximizing production and harvest ..
  5. Development of Germplasm Resources for Preservation of Aquatic Models
    TERRENCE ROBERT TIERSCH; Fiscal Year: 2011
    ..resources by: 1) reducing size and production costs of facilities, 2) protecting genetic diversity and reducing inbreeding, 3) maximizing efficiency of holding live animals, and 3) facilitating global, regional, and institutional ..
  6. A resource for the genetic analysis of complex traits
    STUART JOHN MACDONALD; Fiscal Year: 2012
    ..The two heterozygous testcrosses will examine the effect of inbreeding on QTL mapping directly in RILs...
  7. ESTABLISHMENT OF A SPF RHESUS MACAQUE COLONY
    John L Vandeberg; Fiscal Year: 2013
    ..records, will be used to establish and verify pedigree information, and to manage breeding in order to avoid inbreeding and to maintain genetic variability, while focusing on the primary goal of maximizing production and harvest by ..
  8. Inferring phenogentic mechanisms in psychiatric and other complex traits
    JOSEPH DOUGLAS TERWILLIGER; Fiscal Year: 2012
    ..the rates of mutation, the effects of demographic structure (including assortative mating, migration, drift, inbreeding and the like), and potential effects of natural selection in molding the genetic portion of the etiological ..
  9. THEORETICAL POPULATION GENETICS
    Bruce S Weir; Fiscal Year: 2013
    ..patterns within and between genetic markers and along haplotypes, and the characterization of relatedness and inbreeding for individuals...
  10. Population genetic inferences from dense genotype data
    Rasmus Nielsen; Fiscal Year: 2013
    ..around, we will develop approaches for inference of population genetic parameters, such as demography, rates of inbreeding, levels of purifying and positive selection, admixture and migration based only on the patterns of IBD sharing...
  11. Population genetic studies of human copy-number polymorphisms
    Catarina D Campbell; Fiscal Year: 2012
    ..This cohort offers a unique oppurtunity to study individuals with a high degreee of allele sharing, due to inbreeding, but who are separated by an average of eight meioses...
  12. Restless Legs Syndrome- The Iron-Dopamine Connection
    Christopher Earley; Fiscal Year: 2009
    ..4) Investigators will use sophisticated PET, MRI, neuropathological, biological, and mice inbreeding approaches that have been incorporated to facilitate novel insights into the interaction of iron, dopamine and ..
  13. Establishment of Specific Pathogen-Free Rhesus Macaque Colonies
    Cynthia J Doane; Fiscal Year: 2010
    ..can be used to efficiently produce large numbers of offspring carrying the desired allele without resorting to inbreeding The current level of genetic characterization in the colony will be expanded to include MHC class II loci...
  14. Molecular Basis of Hereditary Retinal Degenerations
    Radha Ayyagari; Fiscal Year: 2013
    ..Populations with high inbreeding and consanguineous marriages are best suited for identifying genes associated with recessive retinal conditions...
  15. Factors Affecting Prediction Accuracy of Complex Human Traits and Diseases
    GUSTAVO A DE LOS CAMPOS; Fiscal Year: 2013
    ..in aspects such as selection history, distribution of allele frequency, extent linkage disequilibrium (LD) and inbreeding. And preliminary evidence indicates that these factors can impact the predictive performance of WGP...
  16. The effect of coinheritance on host-symbiont coevolution
    Michael J Wade; Fiscal Year: 2013
    ..of selfing and discovered that inter-genomic transfer of functional genes is ten-fold more likely to occur in inbreeding species than in outcrossing species...
  17. BPH AND PROSTATE CA IN 5A-REDUCTASE-2 DEFICIENT CARRIERS
    Julianne Imperato McGinley; Fiscal Year: 2000
    ..The field work will be carried out in two Dominican villages where there is extensive inbreeding, and where the largest kindred in the world exists with inherited 5alpha-reductase deficiency, and where the ..
  18. GOAT MODEL OF EHRLICHIA CHAFFEENSIS RESERVOIR INFECTION
    Susan Little; Fiscal Year: 2000
    ..deer for research, a higher degree of similarity can be obtained between experimental animals due to controlled inbreeding, they are easily raised in tick-free (and thus Ehrlichia-exposure free) facilities, and a larger variety of ..
  19. IDENTICAL BY DESCENT MAPPING OF CRANIOFACIAL ANOMALIES
    Andrew Lidral; Fiscal Year: 1999
    ..Therefore, these families will also be recruited. An important ramification of inbreeding is that in a family, individuals with a rare recessive disease are likely to have inherited both copies of the ..
  20. GENETIC SELECTION FOR BENZODIAZEPINE SENSITIVITY
    EDWARD GALLAHER; Fiscal Year: 1990
    ..Mass selection leads to rapid deivergence, but inbreeding may limit the value of these animals for subsequent long-term studies...
  21. MATHEMATICAL POPULATION GENETICS
    Marcy K Uyenoyama; Fiscal Year: 2013
    ..statistics of genome-scale variation under various forms of population structure, including regular systems of inbreeding and population subdivision...
  22. CHIMPANZEE BREEDING AND RESEARCH PROGRAM
    Jo Fritz; Fiscal Year: 1999
    ..D., Southwest Foundation for Biomedical Research. PFA management protocols and records that assist toward inbreeding avoidance and assurance that no one animal over-contributes to the population will continue to be followed and ..
  23. ENHANCING IN VITRO PRODUCTION OF RARE EMBRYOS
    Rebecca Spindler; Fiscal Year: 2002
    ..pathology patterns similar to humans, but these cats often fail to reproduce because of infertility related to inbreeding or the disease itself...
  24. GENETIC MODEL OF ENDURANCE EXERCISE IN RATS
    STEVEN BRITTON; Fiscal Year: 2003
    ..Selection for best aerobic performers will be continued throughout the inbreeding. 3...
  25. TOLERANCE TO VASCULARIZED ALLOGRAFTS IN MINISWINE
    David Sachs; Fiscal Year: 2005
    ..during the last project period we have established fully histocompatible miniature swine through further inbreeding, making it possible to utilize adoptive transfer techniques to investigate the mechanism of tolerance for the ..
  26. Increasing DNA marker informativeness in hereditary canine motor neuron disease
    Martin Pinter; Fiscal Year: 2009
    ..The likely cause of this is the extensive amount of inbreeding that has occurred in the HCSMA colony over the years...
  27. DETECTING AND MAPPING SEQUENCE CHANGES IN DNA
    Rosemary Elliott; Fiscal Year: 1990
    ..should be characterized by polymorphic variation, such that any given pair of strains which do not have a recent inbreeding history have different alleles at about half the loci...
  28. Latitude and the Duration of Neartic WNV Outbreaks
    Dyann Wirth; Fiscal Year: 2007
    ..The presence of inbreeding autogenous populations will be investigated...
  29. NON-INVASIVE DNA ANALYSIS FOR PRIMATE MANAGEMENT
    David Woodruff; Fiscal Year: 1990
    ..These projects thus focus on very general health problems affecting all captive breeding groups: inbreeding depression, outbreeding depression and the maintenance of genetic variation...
  30. PATHOGEN FREE RHESUS MONKEY BREEDING AND RESEARCH
    Prabhat Sehgal; Fiscal Year: 1999
    ..genetic diversity of the breeding colony will be maximized by tracking of individual animal pedigrees to avoid inbreeding and by periodic determination of average heterozygosity through analysis blood protein polymorphism...
  31. GENETICS AND INBREEDING IN NONHUMAN PRIMATES
    Bennett Dyke; Fiscal Year: 1993
    ..In the work proposed, we will continue to use data provided by these investigators and to share with them our programs and our computing expertise...
  32. DIVERSITY IN H-2 HAPLOTYPES
    Larry Pease; Fiscal Year: 1990
    ..it is of great interest to define which polymorphisms are relevant to the diversification of alleles within inbreeding populations and which are representative of individuals from genetically isolated populations...
  33. CHARACTERIZATION OF HEREDITARY CEREBELLAR ATAXIA
    DANIEL TOLBERT; Fiscal Year: 1991
    ..The defect is hereditary, appearing in the second generation of inbreeding affected rats. The breeding colony has remained free of murine pathogens including "rat parvovirus other"...
  34. PATHOPHYSIOLOGY OF MICROCIRCULATION IN HYPERTENSION
    WILLIAM JOYNER; Fiscal Year: 1990
    ..We have been inbreeding the golden Syrian hamster (Mesecricetus auratus) and we find that strains characterized by their phenotypic ..
  35. NEW MOUSE MODELS OF DIABESITY
    Edward Leiter; Fiscal Year: 2002
    ..A series of 9 QTL locus-directed recombinant congenic stocks (RCS) has been created by inbreeding at second backcross to the NON-parental strain...
  36. GENE MARKERS IN SCHIZOPHRENIA AND OTHER PSYCHOSES
    Miron Baron; Fiscal Year: 1991
    ..Multigenerational pedigrees with large sibships, known genealogical roots, inbreeding effects, and low rates of alcoholism, drug abuse, crimes and acts of violence, conditions that confound the ..
  37. Consanguinity and risk of Bipolar Disorder I in Egypt
    Vishwajit Nimgaonkar; Fiscal Year: 2007
    ..If the risk for BD1 varies with levels of inbreeding in Egypt, then at least some of the susceptibility loci are likely to act recessively...
  38. MAJOR HISTOCOMPATIBILTY COMPLEX--AGING & TRANSGENIC MICE
    Rita Effros; Fiscal Year: 1992
    ..Further inbreeding of Peromyscus and serologic and molecular genetic studies of Peromyscus MHC will also be done, as adjunct to the ..
  39. STATISTICAL METHODS FOR MAPPING MULTIVARIATE PHENOTYPES
    Saurabh Ghosh; Fiscal Year: 2007
    ..computer programs incorporating the methodologies, (v) to modify the proposed methods to incorporate inbreeding practiced in some populations and (vi) to apply the new methods to data on different types of complex traits/..
  40. POPULATION GENETICS OF INTERACTIONS
    RICHARD MICHOD; Fiscal Year: 1999
    ..Fourth, I propose studying the effect of inbreeding on the evolution of social behavior and the effect of social behavior on the evolution of inbreeding...
  41. DIFFERENTIAL EXPRESSION OF SLE IN NZB/NZW RI MICE
    ULRICH RUDOFSKY; Fiscal Year: 1993
    ..Therefore, it is remarkable that severe early LPN persists in several of our RIS, now at F20-27 of inbreeding; furthermore, the gene(s) susceptible to androgen modulation seems to be differently expressed; males in some ..
  42. CORRELATED CHARACTERS IN COMPLEX GENETIC SYSTEMS
    Russell Lande; Fiscal Year: 1993
    ..Associations and interactions among molecular marker loci, genes contributing to inbreeding depression (e.g...
  43. GENETIC MAPPING IN THE HYPERCALCIURIC STONE-FORMING RAT
    STEVEN SCHEINMAN; Fiscal Year: 2003
    ..model exists in the genetic hypercalciuric stone-forming (GHS) rat, which is now in its 51st generation of inbreeding. The physiology of hypercalciuria in this model has been extensively characterized and resembles human IH in ..
  44. MOUSE MODELS WITH DELAYED PATHOLOGIES
    David Harrison; Fiscal Year: 2005
    ..To avoid inadvertent inbreeding depression, controls will be selected from the initial four-way crosses...
  45. SOCIAL INFLUENCE ON DISPERSAL IN MALES AND FEMALES
    NANCY SOLOMON; Fiscal Year: 1999
    ..In contrast, the inbreeding avoidance hypothesis predicts that opposite- sex conspecifics should induce emigration...
  46. Ecological functional genomics: phenotyping Hox mutants
    WAYNE POTTS; Fiscal Year: 2007
    ..For example, the deleterious effects of inbreeding in mice are barely detectable using lab assays (10% effect), but when analyzed under competitive ecological ..
  47. HEREDITARY CATARACT; ANATOMIC-METABOLIC CHANGES
    STEPHEN BISTNER; Fiscal Year: 1980
    Intensive inbreeding and line-breeding of purebred dogs in the United States has resulted in nurmerous breeds developing hereditary cataracts of both the congenital and developmental forms...
  48. CHARACTERIZATION OF DELETERIOUS GENOMIC MUTATIONS
    Hong Wen Deng; Fiscal Year: 2005
    ..between the two long- standing rival hypotheses concerning the maintenance of genetic variability and inbreeding depression-namely, the dominance and overdominance hypotheses; 3) investigate the statistical properties of the ..
  49. GENETIC ANALYSIS OF FGF-5 PROTO-ONCOGENE FUNCTION
    Mitchell Goldfarb; Fiscal Year: 1992
    ..b>Inbreeding will be performed to determine the developmental abnormalities in FGF-5 negative embryos...
  50. Bayesian methods for analyzing genetic diversity
    KENT HOLSINGER; Fiscal Year: 2006
    ..Moreover, we develop refinements to existing user-friendly software implementing the methods we develop and make the software and the associated source code freely available under the GNU General Public license. ..
  51. Neural basis of heritable DA-mediated gating deficits
    Neal R Swerdlow; Fiscal Year: 2010
    ....
  52. GENES FOR ALCOHOLISM SUSCEPTIBILITY
    Tatiana Foroud; Fiscal Year: 2003
    ..These studies will result in more sophisticated genetic analyses of alcoholism related data, as well as the development of optimum sampling designs for more efficient gene identification. ..
  53. GPCR signaling cascades in Cryptococcus neoformans
    Joseph Heitman; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  54. Longitudinal Studies Among At-Risk HD Gene Carriers
    Tatiana Foroud; Fiscal Year: 2006
    ..abstract_text> ..
  55. NEURAL CIRCUITRY OF SENSORIMOTOR GATING ACROSS SPECIES
    Neal Swerdlow; Fiscal Year: 2006
    ....
  56. WILD DERIVED MOUSE STOCKS--NEW MODELS FOR AGING RESEARCH
    Richard Miller; Fiscal Year: 2004
    ....
  57. CORTICO-STRIATAL SUBSTRATES OF DEFICIENT STARTLE GATING
    Neal R Swerdlow; Fiscal Year: 2010
    ..New information from these studies will be a foundation for innovative models of the pathophysiology of schizophrenia and other inherited neuropsychiatric disorders, and for prospective strategies for novel drug development. ..