fertilization in vitro

Summary

Summary: An assisted reproductive technique that includes the direct handling and manipulation of oocytes and sperm to achieve fertilization in vitro.

Top Publications

  1. ncbi ESHRE consensus on the definition of 'poor response' to ovarian stimulation for in vitro fertilization: the Bologna criteria
    A P Ferraretti
    S I S Me R Reproductive Medicine Unit, Via Mazzini 12, 40138 Bologna, Italy
    Hum Reprod 26:1616-24. 2011
  2. ncbi Successful piglet production after transfer of blastocysts produced by a modified in vitro system
    Kazuhiro Kikuchi
    Genetic Diversity Department, National Institute of Agrobiological Sciences, Kannondai 2 1 2, Tsukuba, Ibaraki 305 8602, Japan
    Biol Reprod 66:1033-41. 2002
  3. ncbi Oocyte-secreted factors: regulators of cumulus cell function and oocyte quality
    Robert B Gilchrist
    Research Centre for Reproductive Health, School of Paediatrics and Reproductive Health, Discipline of Obstetrics and Gynaecology, Medical School, University of Adelaide, Adelaide 5005, Australia
    Hum Reprod Update 14:159-77. 2008
  4. ncbi Mitochondrial dysfunction in mouse oocytes results in preimplantation embryo arrest in vitro
    George A Thouas
    Monash Institute of Reproduction and Development, Monash University, Clayton, Victoria 3168, Australia
    Biol Reprod 71:1936-42. 2004
  5. ncbi The poor responder in IVF: is the prognosis always poor?: a systematic review
    J F Oudendijk
    Department of Reproductive Medicine and Gynaecology, University Medical Center Utrecht, GA Utrecht, The Netherlands
    Hum Reprod Update 18:1-11. 2012
  6. ncbi Women's emotional adjustment to IVF: a systematic review of 25 years of research
    C M Verhaak
    Department of Medical Psychology, Radboud University Nijmegen, Medical Centre, Nijmegen, The Netherlands
    Hum Reprod Update 13:27-36. 2007
  7. ncbi Association between the number of eggs and live birth in IVF treatment: an analysis of 400 135 treatment cycles
    Sesh Kamal Sunkara
    Guy s and St Thomas Foundation Trust, King s College London, London, UK
    Hum Reprod 26:1768-74. 2011
  8. ncbi Oxidative stress and protection against reactive oxygen species in the pre-implantation embryo and its surroundings
    P Guerin
    Ecole Nationale Veterinaire de Lyon, Unité Biologie de la Reproduction, Marcy l Etoile, France
    Hum Reprod Update 7:175-89. 2001
  9. ncbi Requirement of CD9 on the egg plasma membrane for fertilization
    K Miyado
    Institute of Life Science, Kurume University, Kurume, Fukuoka 839 0861, Japan
    Science 287:321-4. 2000
  10. ncbi AMH and AFC as predictors of excessive response in controlled ovarian hyperstimulation: a meta-analysis
    S L Broer
    Department of Reproductive Medicine and Gynecology, University Medical Center, GA Utrecht, The Netherlands
    Hum Reprod Update 17:46-54. 2011

Detail Information

Publications416 found, 100 shown here

  1. ncbi ESHRE consensus on the definition of 'poor response' to ovarian stimulation for in vitro fertilization: the Bologna criteria
    A P Ferraretti
    S I S Me R Reproductive Medicine Unit, Via Mazzini 12, 40138 Bologna, Italy
    Hum Reprod 26:1616-24. 2011
    ..Finally, by reducing bias caused by spurious POR definitions, it will be possible to compare results and to draw reliable conclusions...
  2. ncbi Successful piglet production after transfer of blastocysts produced by a modified in vitro system
    Kazuhiro Kikuchi
    Genetic Diversity Department, National Institute of Agrobiological Sciences, Kannondai 2 1 2, Tsukuba, Ibaraki 305 8602, Japan
    Biol Reprod 66:1033-41. 2002
    ..This system has advantages for the generation of cloned and transgenic pigs...
  3. ncbi Oocyte-secreted factors: regulators of cumulus cell function and oocyte quality
    Robert B Gilchrist
    Research Centre for Reproductive Health, School of Paediatrics and Reproductive Health, Discipline of Obstetrics and Gynaecology, Medical School, University of Adelaide, Adelaide 5005, Australia
    Hum Reprod Update 14:159-77. 2008
    ....
  4. ncbi Mitochondrial dysfunction in mouse oocytes results in preimplantation embryo arrest in vitro
    George A Thouas
    Monash Institute of Reproduction and Development, Monash University, Clayton, Victoria 3168, Australia
    Biol Reprod 71:1936-42. 2004
    ..These findings have important implications for the treatment of clinically infertile women using assisted reproductive technologies...
  5. ncbi The poor responder in IVF: is the prognosis always poor?: a systematic review
    J F Oudendijk
    Department of Reproductive Medicine and Gynaecology, University Medical Center Utrecht, GA Utrecht, The Netherlands
    Hum Reprod Update 18:1-11. 2012
    ..Applying these criteria will allow the identification of couples with a reasonable prognosis and balanced decision-making on the management of poor responders...
  6. ncbi Women's emotional adjustment to IVF: a systematic review of 25 years of research
    C M Verhaak
    Department of Medical Psychology, Radboud University Nijmegen, Medical Centre, Nijmegen, The Netherlands
    Hum Reprod Update 13:27-36. 2007
    ....
  7. ncbi Association between the number of eggs and live birth in IVF treatment: an analysis of 400 135 treatment cycles
    Sesh Kamal Sunkara
    Guy s and St Thomas Foundation Trust, King s College London, London, UK
    Hum Reprod 26:1768-74. 2011
    ..The aim of this study was to explore the association between egg number and live birth following IVF treatment and identify the number of eggs that would optimize the IVF outcome...
  8. ncbi Oxidative stress and protection against reactive oxygen species in the pre-implantation embryo and its surroundings
    P Guerin
    Ecole Nationale Veterinaire de Lyon, Unité Biologie de la Reproduction, Marcy l Etoile, France
    Hum Reprod Update 7:175-89. 2001
    ..Nevertheless, maintaining the pro-oxidant-antioxidant equilibrium in embryos through such supplementation is a complex problem. Further studies are necessary to limit oxidative stress during embryo culture...
  9. ncbi Requirement of CD9 on the egg plasma membrane for fertilization
    K Miyado
    Institute of Life Science, Kurume University, Kurume, Fukuoka 839 0861, Japan
    Science 287:321-4. 2000
    ..When sperm were injected into oocytes with assisted microfertilization techniques, however, the fertilized eggs developed to term. These results indicate that CD9 has a crucial role in sperm-egg fusion...
  10. ncbi AMH and AFC as predictors of excessive response in controlled ovarian hyperstimulation: a meta-analysis
    S L Broer
    Department of Reproductive Medicine and Gynecology, University Medical Center, GA Utrecht, The Netherlands
    Hum Reprod Update 17:46-54. 2011
    ..The aim of this study was to assess the accuracy of AMH and antral follicle count (AFC) as predictors of an excessive response in IVF/ICSI treatment...
  11. ncbi Assisted reproductive technology in Europe, 2006: results generated from European registers by ESHRE
    J de Mouzon
    ESHRE Central Office, Meerstraat 60, B 1852 Grimbergen, Belgium
    Hum Reprod 25:1851-62. 2010
    ..In this 10th European IVF-monitoring (EIM) report, the results of assisted reproductive techniques from treatments initiated in Europe during 2006 are presented. Data were mainly collected from existing national registers...
  12. ncbi Serum anti-Müllerian hormone levels: a novel measure of ovarian reserve
    I A J van Rooij
    Department of Reproductive Medicine, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, Netherlands
    Hum Reprod 17:3065-71. 2002
    ..Therefore, we studied the relationship between AMH levels and ovarian response during ovarian stimulation for IVF...
  13. ncbi New method for culture of zona-included or zona-free embryos: the Well of the Well (WOW) system
    G Vajta
    Embryo Technology Center, Danish Institute of Agricultural Sciences, Research Centre Foulum, Tjele, Denmark
    Mol Reprod Dev 55:256-64. 2000
    ..Apart from its theoretical value in revealing the role of different factors influencing embryo development in vitro, the WOW system may have immediate practical consequences in certain areas of mammalian embryo production...
  14. ncbi Noninvasive metabolomic profiling of human embryo culture media using Raman spectroscopy predicts embryonic reproductive potential: a prospective blinded pilot study
    Richard Scott
    Reproductive Medicine Associates of New Jersey, Morristown, New Jersey, USA
    Fertil Steril 90:77-83. 2008
    ..To determine if metabolomic profiling of embryonic development was associated with implantation rates in IVF...
  15. ncbi Assisted reproductive technology in Europe, 2004: results generated from European registers by ESHRE
    A Nyboe Andersen
    ESHRE Central Office, Meerstraat 60, B 1852 Grimbergen, Belgium
    Hum Reprod 23:756-71. 2008
    ..European results of assisted reproductive techniques from treatments initiated during 2004 are presented in this eighth report...
  16. ncbi The role of antimullerian hormone in prediction of outcome after IVF: comparison with the antral follicle count
    Simone L Broer
    Department of Reproductive Medicine, Division of Obstetrics, Neonatology, and Gynecology, University Medical Center, Utrecht, The Netherlands
    Fertil Steril 91:705-14. 2009
    ..To assess the value of antimullerian hormone (AMH) as a test to predict poor ovarian response and pregnancy occurrence after IVF and to compare it with the performance of the antral follicle count (AFC)...
  17. ncbi A non-invasive test for assessing embryo potential by gene expression profiles of human cumulus cells: a proof of concept study
    S Assou
    CHU Montpellier, Institut de Recherche en Biothérapie, Hopital Saint Eloi, Montpellier F 34000, France
    Mol Hum Reprod 14:711-9. 2008
    ..Our findings suggest a non-invasive approach, offering a new potential strategy for competent embryo selection. This approach should be validated in single-embryo transfer programmes...
  18. ncbi Measuring anti-Müllerian hormone for the assessment of ovarian reserve: when and for whom is it indicated?
    R A Anderson
    Division of Reproductive and Developmental Sciences, University of Edinburgh, Edinburgh, Scotland, UK
    Maturitas 71:28-33. 2012
    ..The increasingly routine use of AMH by IVF clinics heralds much wider adoption in a range of clinical situations across the reproductive lifespan...
  19. ncbi Maternal and child outcome after in vitro fertilization--a review of 25 years of population-based data from Sweden
    Orvar Finnström
    Department of Pediatrics, University Hospital, Linkoping, Sweden
    Acta Obstet Gynecol Scand 90:494-500. 2011
    ..To summarize data on deliveries after in vitro fertilization (IVF) performed in Sweden up to 2006...
  20. ncbi Translocation of active mitochondria during pig oocyte maturation, fertilization and early embryo development in vitro
    Q Y Sun
    Department of Veterinary Pathobiology, University of Missouri-Columbia, Columbia, MO 65211, USA
    Reproduction 122:155-63. 2001
    ....
  21. ncbi An OHSS-Free Clinic by segmentation of IVF treatment
    Paul Devroey
    Centre for Reproductive Medicine, UZ Brussel, Laarbeeklaan 101, 1090 Brussels, Belgium
    Hum Reprod 26:2593-7. 2011
    ..The syndrome can be erased by applying ovarian stimulation using the combination of GnRH antagonist with GnRH agonist to trigger ovulation. In this case, the strategy is to freeze all of the oocytes or embryos for later use...
  22. ncbi Utility of age-specific serum anti-Müllerian hormone concentrations
    David H Barad
    Center for Human Reproduction New York and Foundation for Reproductive Medicine, New York, NY, USA
    Reprod Biomed Online 22:284-91. 2011
    ....
  23. pmc Association of FMR1 genotypes with in vitro fertilization (IVF) outcomes based on ethnicity/race
    Norbert Gleicher
    Center for Human Reproduction and Foundation for Reproductive Medicine, New York, New York, United States of America
    PLoS ONE 6:e18781. 2011
    ..5-times the odds of being associated with autoimmune positivity (OR 2.5, 1.34-4.55; P = 0.004). FMR1 genotypes offer a possible explanation for differences in IVF outcomes between races/ethnicities...
  24. ncbi Risk of contamination of germplasm during cryopreservation and cryobanking in IVF units
    A Bielanski
    Canadian Food Inspection Agency, Animal Diseases Research Institute, Germplasm Centre of Expertise, Ottawa Nepean, ON, Canada K2H 8P9
    Hum Reprod 24:2457-67. 2009
    ..Suggestions are also made for practical measures to avoid these dangers while preserving the benefits and perspectives of new cryopreservation technologies...
  25. ncbi Up date of in vitro production of porcine embryos
    Takashi Nagai
    National Institute of Livestock and Grassland Science, 2 Ikenodai, Tsukuba, Ibaraki, 305 0901, Japan
    Front Biosci 11:2565-73. 2006
    ..We then try to suggest practical ways to solve the problems mentioned above in the pigs...
  26. ncbi Apoptosis and in vitro development of preimplantation porcine embryos derived in vitro or by nuclear transfer
    Yanhong Hao
    Department of Animal Sciences, University of Missouri Columbia, Columbia, Missouri 65211, USA
    Biol Reprod 69:501-7. 2003
    ..The developmental rates of NT embryos might be improved by identifying specific apoptotic pathways and then intervening in these pathways to improve development...
  27. pmc Follicular fluid content and oocyte quality: from single biochemical markers to metabolomics
    Alberto Revelli
    Reproductive Medicine and IVF Unit, Department of Obstetrical and Gynecological Sciences, University of Torino, Via Ventimiglia 3, 10126 Torino, Italy
    Reprod Biol Endocrinol 7:40. 2009
    ....
  28. ncbi A longitudinal, prospective study on emotional adjustment before, during and after consecutive fertility treatment cycles
    C M Verhaak
    Department of Medical Psychology, Department of Obstetrics and Gynaecology, University Medical Centre St Radboud, Nijmegen, The Netherlands
    Hum Reprod 20:2253-60. 2005
    ..A longitudinal study into the course of the emotional response to IVF from pre-treatment to 6 months post-treatment and factors that contributed to that course...
  29. ncbi Aberrant methylation of donor genome in cloned bovine embryos
    Y K Kang
    Animal Developmental Biotechnology Laboratory, Korea Research Institute of Bioscience and Biotechnology (KRIBB, PO Box 115, Yusong, Taejon, 305-600, South Korea
    Nat Genet 28:173-7. 2001
    ..Our findings indicate that the developmental anomalies of cloned embryos could be due to incomplete epigenetic reprogramming of donor genomic DNA...
  30. pmc Effects of acupuncture on rates of pregnancy and live birth among women undergoing in vitro fertilisation: systematic review and meta-analysis
    Eric Manheimer
    Center for Integrative Medicine, University of Maryland School of Medicine, 2200 Kernan Drive, Kernan Hospital Mansion, Baltimore, MD 21207, USA
    BMJ 336:545-9. 2008
    ..To evaluate whether acupuncture improves rates of pregnancy and live birth when used as an adjuvant treatment to embryo transfer in women undergoing in vitro fertilisation...
  31. ncbi p53 tumour suppressor gene polymorphism is associated with recurrent implantation failure
    C Kay
    Andrology Laboratory Services, Chicago, IL, USA
    Reprod Biomed Online 13:492-6. 2006
    ..It is concluded that p53 codon 72 polymorphisms may serve as a susceptibility factor affecting the chances of recurrent implantation after IVF or embryo transfer...
  32. ncbi Blastocyst score affects implantation and pregnancy outcome: towards a single blastocyst transfer
    D K Gardner
    Colorado Center for Reproductive Medicine, Englewood, Colorado, USA
    Fertil Steril 73:1155-8. 2000
    ..To determine the relationship between blastocyst score and pregnancy outcome...
  33. ncbi Anti-mullerian hormone as a marker of ovarian reserve
    Kelton P Tremellen
    Reproductive Medicine Laboratories, South Australia
    Aust N Z J Obstet Gynaecol 45:20-4. 2005
    ..To analyse the usefulness of plasma anti-mullerian hormone (AMH) measurement as a tool for assessing ovarian reserve in a general infertility population...
  34. ncbi Cumulus gene expression as a predictor of human oocyte fertilisation, embryo development and competence to establish a pregnancy
    R A Anderson
    Division of Reproduction and Developmental Science, Queen s Medical Research Institute, Centre for Reproductive Biology, University of Edinburgh, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK
    Reproduction 138:629-37. 2009
    ....
  35. ncbi Studies of gene expression in human cumulus cells indicate pentraxin 3 as a possible marker for oocyte quality
    Xingqi Zhang
    Section of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Northwestern University Feinberg School of Medicine, 675 North Saint Clair Street, Chicago, IL 60611, USA
    Fertil Steril 83:1169-79. 2005
    ..To search for differentially expressed genes in cumulus cells from two groups of oocytes with different developmental outcome in vitro...
  36. ncbi Genetic predictors of controlled ovarian hyperstimulation: where do we stand today?
    S Altmäe
    Division of Obstetrics and Gynaecology, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Karolinska University Hospital Huddinge, 14186 Stockholm, Sweden
    Hum Reprod Update 17:813-28. 2011
    ..Pharmacogenetic studies demonstrate the effects of individual genetic variability on COH outcome and the potential for customizing therapy based on the patient's genome...
  37. ncbi Predictive factors in in vitro fertilization (IVF): a systematic review and meta-analysis
    L L van Loendersloot
    Department of Obstetrics and Gynaecology, Centre for Reproductive Medicine, Meibergdreef 9, Amsterdam, The Netherlands
    Hum Reprod Update 16:577-89. 2010
    ..These models differ from one another in the predictors they include. We performed a systematic review and meta-analysis to identify the most relevant predictors for success in IVF...
  38. ncbi Human cumulus granulosa cell gene expression: a predictor of fertilization and embryo selection in women undergoing IVF
    L J McKenzie
    Department of Obstetrics, Baylor College of Medicine, Houston, TX 77030, USA
    Hum Reprod 19:2869-74. 2004
    ....
  39. ncbi Endocrine profile in serum and follicular fluid differs after ovarian stimulation with HP-hMG or recombinant FSH in IVF patients
    J Smitz
    Follicle Biology Laboratory and Center for Reproductive Medicine, Academisch Ziekenhuis Vrije Universiteit Brussel, Belgium
    Hum Reprod 22:676-87. 2007
    ..Highly purified menotrophin (HP-hMG) has been associated with fewer oocytes retrieved and a higher proportion of top-quality embryos compared with recombinant FSH (rFSH)...
  40. ncbi Perinatal outcomes in singletons following in vitro fertilization: a meta-analysis
    Rebecca A Jackson
    Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Francisco, 505 Parnassus Avenue, Box 0132, San Francisco, CA 94143, USA
    Obstet Gynecol 103:551-63. 2004
    ....
  41. ncbi Dynamic assays of inhibin B, anti-Mullerian hormone and estradiol following FSH stimulation and ovarian ultrasonography as predictors of IVF outcome
    Talia Eldar-Geva
    IVF Unit, Department of Obstetrics and Gynecology, Shaare Zedek Medical Center, Ben Gurion University of the Negev, Jerusalem 91031, Israel
    Hum Reprod 20:3178-83. 2005
    ....
  42. ncbi Evaluation of anti-Müllerian hormone as a test for the prediction of ovarian reserve
    Janet Kwee
    Division of Reproductive Endocrinology and Fertility and IVF Centre, Department of Obstetrics and Gynaecology, Vrije Universiteit Medical Centre, Amsterdam, The Netherlands
    Fertil Steril 90:737-43. 2008
    ..To compare in an integral way the value of the basal serum anti-Müllerian hormone (AMH) level with most of the established ovarian reserve tests...
  43. ncbi Antral follicle count in the prediction of poor ovarian response and pregnancy after in vitro fertilization: a meta-analysis and comparison with basal follicle-stimulating hormone level
    Dave J Hendriks
    Department of Reproductive Medicine, Division of Obstetrics, Neonatology and Gynecology, University Medical Center Utrecht, Utrecht, The Netherlands
    Fertil Steril 83:291-301. 2005
    ..To assess the predictive performance of the antral follicle count (AFC) as a test for ovarian reserve in IVF patients and to compare this performance with that of basal FSH level...
  44. ncbi Comparing anti-Müllerian hormone (AMH) and follicle-stimulating hormone (FSH) as predictors of ovarian function
    David H Barad
    Center for Human Reproduction, New York, New York 10021, USA
    Fertil Steril 91:1553-5. 2009
    ..In 76 IVF cycles investigated, AMH was clearly superior in predicting IVF outcomes in comparison with FSH...
  45. ncbi Anti-Müllerian hormone as a predictor of IVF outcome
    Dharmawijaya N Lekamge
    Research Centre for Reproductive Health, Discipline of Obstetrics and Gynaecology, School of Paediatrics and Reproductive Health, University of Adelaide, 5005 Adelaide, South Australia, Australia
    Reprod Biomed Online 14:602-10. 2007
    ....
  46. ncbi Circulating basal anti-Müllerian hormone levels as predictor of ovarian response in women undergoing ovarian stimulation for in vitro fertilization
    Luciano G Nardo
    Department of Reproductive Medicine, St Mary s Hospital, Manchester, United Kingdom
    Fertil Steril 92:1586-93. 2009
    ..To evaluate the clinical value of basal anti-Müllerian hormone (AMH) measurements compared with other available determinants, apart from chronologic age, in the prediction of ovarian response to gonadotrophin stimulation...
  47. ncbi Age-specific levels for basal follicle-stimulating hormone assessment of ovarian function
    David H Barad
    Center for Human Reproduction, New York and the Foundation for Reproductive Medicine, Chicago, Illinois, USA
    Obstet Gynecol 109:1404-10. 2007
    ..The objective of this study was to characterize the continuum of ovarian function based on age-specific categories of baseline FSH...
  48. ncbi Ubiquitin-proteasome pathway modulates mouse oocyte meiotic maturation and fertilization via regulation of MAPK cascade and cyclin B1 degradation
    Li Jun Huo
    State Key Laboratory of Reproductive Biology, Institute of Zoology, Graduate School of the Chinese Academy of Sciences, Beijing 100080, China
    Mech Dev 121:1275-87. 2004
    ....
  49. ncbi Errors in development of fetuses and placentas from in vitro-produced bovine embryos
    Peter W Farin
    Department of Population Health and Pathobiology, North Carolina State University, Raleigh, NC 27606, USA
    Theriogenology 65:178-91. 2006
    ..We also discuss potential genetic and physiologic mechanisms that may contribute to abnormal phenotypes following transfer of IVP and SCNT embryos...
  50. ncbi Chromosomal mosaicism in human preimplantation embryos: a systematic review
    Jannie van Echten-Arends
    Section of Reproductive Medicine, Department of Obstetrics and Gynaecology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Hum Reprod Update 17:620-7. 2011
    ..The prevalence of mosaicism is important in the context of preimplantation genetic screening in which the chromosomal status of an embryo is determined by the analysis of a single cell from that embryo...
  51. pmc Maturation, fertilization, and the structure and function of the endoplasmic reticulum in cryopreserved mouse oocytes
    Katie M Lowther
    Department of Cell Biology, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    Biol Reprod 81:147-54. 2009
    ..Deficiencies in factors that are responsible for proper ER reorganization during oocyte maturation could contribute to the low developmental potential previously reported in vitrified in vitro-matured oocytes...
  52. ncbi Identification of viable embryos in IVF by non-invasive measurement of amino acid turnover
    D R Brison
    Department of Reproductive Medicine, St Mary s Hospital, Manchester M13 OJH, UK
    Hum Reprod 19:2319-24. 2004
    ..We have conducted a retrospective clinical study of a novel non-invasive method of embryo selection based on the depletion/appearance of amino acids in the culture medium...
  53. ncbi Effect of resveratrol on the development of porcine embryos produced in vitro
    Kiho Lee
    Department of Animal Sciences, Purdue University, West Lafayette, IN 47907, USA
    J Reprod Dev 56:330-5. 2010
    ..1+/-2.4 vs. 43.2+/-1.7) by the end of the 7-day culture period (P<0.05). The results indicate that 0.5 microM resveratrol during culture has a positive effect on early embryonic development of porcine embryos...
  54. ncbi A prospective study of stress among women undergoing in vitro fertilization or gamete intrafallopian transfer
    H Klonoff-Cohen
    Department of Family and Preventive Medicine, Division of Epidemiology, University of California San Diego, La Jolla, California 92093 0607, USA
    Fertil Steril 76:675-87. 2001
    ..To evaluate whether baseline or procedural stress during in vitro fertilization (IVF) or gamete intrafallopian transfer (GIFT) affects pregnancy or live birth delivery rates...
  55. ncbi Live birth chances in women with extremely low-serum anti-Mullerian hormone levels
    Andrea Weghofer
    Department of Obstetrics and Gynecology, Medical University Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
    Hum Reprod 26:1905-9. 2011
    ..To determine whether women with extremely low-serum anti-Mullerian hormone (AMH) levels (<0.1-0.4 ng/ml) still demonstrate live birth potential with assisted reproduction and whether such potential is age dependent...
  56. ncbi Influence of female bodyweight on IVF outcome: a longitudinal multicentre cohort study of 487 infertile couples
    A Pinborg
    Fertility Clinic, The Juliane Marie Center, Rigshospitalet, University of Copenhagen, Copenhagen 2100, Denmark
    Reprod Biomed Online 23:490-9. 2011
    ..04). Live-birth rate per cycle was 15.2% versus 21.5%. Multiple logistic regression analysis showed that the only independent predictors of live birth were women's age (P=0.037), women's BMI (P=0.034) and men's age (P=0.040)...
  57. ncbi Mitochondria directly influence fertilisation outcome in the pig
    Shahinaz H El Shourbagy
    The Mitochondrial and Reproductive Genetics Group, The Medical School, The University of Birmingham, Birmingham B15 2TT, UK
    Reproduction 131:233-45. 2006
    ....
  58. ncbi The effect of recombinant LH on embryo quality: a randomized controlled trial in women with poor ovarian reserve
    A M Musters
    Centre for Reproductive Medicine, Department of Obstetrics and Gynaecology H4 205, Academic Medical Centre, University of Amsterdam, PO Box 22700, Amsterdam 1100 DE, The Netherlands
    Hum Reprod 27:244-50. 2012
    ..For these women, addition of recombinant luteinizing hormone (rLH) to ovarian hyperstimulation with recombinant FSH has a beneficial effect on ongoing pregnancy rates, but its effect on the yield of top-quality embryos is unknown...
  59. ncbi Development and validation of an accurate quantitative real-time polymerase chain reaction-based assay for human blastocyst comprehensive chromosomal aneuploidy screening
    Nathan R Treff
    Reproductive Medicine Associates of New Jersey, Morristown, New Jersey, USA
    Fertil Steril 97:819-24. 2012
    ..To develop and validate a quantitative real-time polymerase chain reaction (qPCR)-based method for blastocyst trophectoderm comprehensive chromosome screening (CCS) of aneuploidy...
  60. pmc Lessons from elective in vitro fertilization (IVF) in, principally, non-infertile women
    Norbert Gleicher
    Center for Human Reproduction, New York, NY 10021, USA
    Reprod Biol Endocrinol 10:48. 2012
    ..Since IVF outcome in women with infertility are always influenced by underlying causes of infertility, a study on non-infertile women may offer new insights...
  61. pmc Starting and resulting testosterone levels after androgen supplementation determine at all ages in vitro fertilization (IVF) pregnancy rates in women with diminished ovarian reserve (DOR)
    Norbert Gleicher
    Center for Human Reproduction, New York, NY 10021, USA
    J Assist Reprod Genet 30:49-62. 2013
    ....
  62. pmc Conserving, distributing and managing genetically modified mouse lines by sperm cryopreservation
    G Charles Ostermeier
    Technology Evaluation and Development, The Jackson Laboratory, Bar Harbor, Maine, United States of America
    PLoS ONE 3:e2792. 2008
    ..Sperm from C57BL/6 mice are difficult to cryopreserve and recover. Yet, the majority of genetically modified (GM) lines are maintained on this genetic background...
  63. ncbi Consequences of bovine oocyte maturation, fertilization or early embryo development in vitro versus in vivo: implications for blastocyst yield and blastocyst quality
    Dimitrios Rizos
    Department of Animal Science and Production and Conway Institute for Biomedical and Biomolecular Research, University College Dublin, Lyons Research Farm, Newcastle, County Dublin, Ireland
    Mol Reprod Dev 61:234-48. 2002
    ..Collectively, these results indicate that the intrinsic quality of the oocyte is the main factor affecting blastocyst yields, while the conditions of embryo culture have a crucial role in determining blastocyst quality...
  64. ncbi DHEA supplementation may improve IVF outcome in poor responders: a proposed mechanism
    Jordana H Hyman
    IVF Unit, Department of Obstetrics and Gynecology, Shaare Zedek Medical Center, Jerusalem 91031, Israel
    Eur J Obstet Gynecol Reprod Biol 168:49-53. 2013
    ..This study aimed to determine the mechanism of action of DHEA, and specifically, the stage of folliculogenesis influenced by DHEA...
  65. ncbi Anti-Müllerian hormone (AMH) defines, independent of age, low versus good live-birth chances in women with severely diminished ovarian reserve
    Norbert Gleicher
    The Center for Human Reproduction and Foundation for Reproductive Medicine, New York, New York 10021, USA
    Fertil Steril 94:2824-7. 2010
    ..04 ng/mL but significantly increased at AMH 0.41-1.05 ng/mL, resulting in similarly low live-birth rates at all AMH levels ≤1.05 ng/mL and significantly improved live-birth rates at AMH ≥1.06 ng/mL...
  66. ncbi Effect of the microenvironment and embryo density on developmental characteristics and gene expression profile of bovine preimplantative embryos cultured in vitro
    Michael Hoelker
    Animal Breeding and Husbandry Group, Insititute of Animal Science, University of Bonn, Bonn, Germany
    Reproduction 137:415-25. 2009
    ..While subsequent blastocysts did not differ in terms of differential cell counts and apoptotic cell index, significant differences were observed in terms of the relative abundance of transcripts in the resulting embryos...
  67. ncbi Elective single embryo transfer and perinatal outcomes: a systematic review and meta-analysis
    Rosheen Grady
    Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada
    Fertil Steril 97:324-31. 2012
    ....
  68. ncbi Baseline psychological stress and ovarian norepinephrine levels negatively affect the outcome of in vitro fertilisation
    Xiao Hong Li
    Reproductive Medical Center of West China 2nd Hospital, Sichuan University, Ren Min Nan Lu, City of Chengdu, Sichuan, 610041, People s Republic of China
    Gynecol Endocrinol 27:139-43. 2011
    ..We determined the effect of baseline psychological stress and norepinephrine (NE) levels in the follicular fluid on the outcome of in vitro fertilisation (IVF)...
  69. ncbi The use of gonadotropin-releasing hormone (GnRH) agonist to induce oocyte maturation after cotreatment with GnRH antagonist in high-risk patients undergoing in vitro fertilization prevents the risk of ovarian hyperstimulation syndrome: a prospective rando
    Lawrence Engmann
    Center for Advanced Reproductive Services, Department of Obstetrics and Gynecology, Dowling South Building, University of Connecticut Health Center, Farmington, Connecticut 06030 6224, USA
    Fertil Steril 89:84-91. 2008
    ....
  70. ncbi Factors affecting low birthweight after assisted reproduction technology: difference between transfer of fresh and cryopreserved embryos suggests an adverse effect of oocyte collection
    W Shih
    Department of Obstetrics and Gynaecology, University of Melbourne, Melbourne, Australia
    Hum Reprod 23:1644-53. 2008
    ..Factors associated with low birthweight (LBW) after assisted reproduction technology (ART) were studied...
  71. ncbi Should fertilization treatment start with reducing stress?
    Daniel M Campagne
    Faculty of Psychology, Department of Personality, Evaluation and Psychological Treatment, UNED University, Madrid and Department of Clinical Psychology, Clinica Bella Medica, Altea, Spain
    Hum Reprod 21:1651-8. 2006
    ..Also, treatment and therapy to reduce stress, and in so doing enhance fertility, do not provoke the ethical and religious objections raised by infertility treatments...
  72. pmc Fresh or frozen? Classifying 'spare' embryos for donation to human embryonic stem cell research
    Kathryn Ehrich
    King s College London, UK
    Soc Sci Med 71:2204-11. 2010
    ....
  73. ncbi Comparison of concomitant outcome achieved with fresh and cryopreserved donor oocytes vitrified by the Cryotop method
    Ana Cobo
    IVI Universidad de Valencia, Valencia, Spain
    Fertil Steril 89:1657-64. 2008
    ..To evaluate the outcome of oocyte vitrification using the Cryotop method, observed in an egg donation program by simultaneously evaluating embryos derived from vitrified and fresh oocytes coming from the same stimulated cycle...
  74. ncbi Noninvasive metabolomic profiling of embryo culture media using Raman and near-infrared spectroscopy correlates with reproductive potential of embryos in women undergoing in vitro fertilization
    Emre Seli
    Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520 8063, USA
    Fertil Steril 88:1350-7. 2007
    ..To determine if metabolomic profiling of embryo culture media correlates with reproductive potential of individual embryos...
  75. ncbi Nonsupplemented luteal phase characteristics after the administration of recombinant human chorionic gonadotropin, recombinant luteinizing hormone, or gonadotropin-releasing hormone (GnRH) agonist to induce final oocyte maturation in in vitro fertilizatio
    Nicole G M Beckers
    Division of Reproductive Medicine, Department of Obstetrics and Gynecology, Erasmus Medical Center, 3015 GD Rotterdam, The Netherlands
    J Clin Endocrinol Metab 88:4186-92. 2003
    ..Hence, support of corpus luteum function remains mandatory after ovarian stimulation for IVF with GnRH antagonist cotreatment...
  76. ncbi What is the preferred GnRH analogue for polycystic ovary syndrome patients undergoing controlled ovarian hyperstimulation for in vitro fertilization?
    Raoul Orvieto
    Department of Obstetrics and Gynecology, Barzilai Medical Center, Ashkelon, Israel
    Fertil Steril 91:1466-8. 2009
    ..The PCOS patients undergoing COH using the GnRH agonist protocol (n = 50) showed a significantly higher pregnancy rate (36% vs. 19.6%, respectively), compared with the GnRH antagonist protocol (n = 102)...
  77. ncbi IVF outcome in women with PCOS, PCO and normal ovarian morphology
    Alexander Swanton
    Royal Berkshire Hospital, Reading, RG1 5AN, UK
    Eur J Obstet Gynecol Reprod Biol 149:68-71. 2010
    ..To examine the outcome of IVF in women who have normal ovaries, ovulatory PCO or PCOS...
  78. ncbi Infertility patients' beliefs about their embryos and their disposition preferences
    V Provoost
    Bioethics Institute Ghent, Ghent University, Blandijnberg 2 B 9000 Ghent, Belgium
    Hum Reprod 24:896-905. 2009
    ..The objective of this study was to describe how patients speak about their embryos, in moral (e.g. status) and non-moral terms, and to investigate how patients' narratives are related to their disposition preferences...
  79. ncbi Suppressed expression of genes involved in transcription and translation in in vitro compared with in vivo cultured bovine embryos
    D Corcoran
    School of Agriculture, Food Science and Veterinary Medicine and Centre for Integrative Biology, Conway Institute for Biomolecular and Biomedical Research, College of Life Sciences, University College Dublin, Belfield, Dublin 4, Ireland
    Reproduction 131:651-60. 2006
    ....
  80. pmc Single-nucleotide polymorphisms in the p53 pathway regulate fertility in humans
    Hey Joo Kang
    Center for Reproductive Medicine and Infertility, Weill Cornell Medical College, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 106:9761-6. 2009
    ..These results also provide a plausible explanation for the evolutionary positive selection of some alleles in the p53 pathway and demonstrate the alleles in the p53 pathway as a good example of antagonistic pleiotropy...
  81. pmc Point of failure as a predictor of in vitro fertilization treatment discontinuation
    Kimberly R Pearson
    Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, USA
    Fertil Steril 91:1483-5. 2009
    ....
  82. pmc The generation of live offspring from vitrified oocytes
    L Gabriel Sanchez-Partida
    Centre for Reproduction and Development, Monash Institute of Medical Research, Monash University, Victoria, Australia
    PLoS ONE 6:e21597. 2011
    ..We conclude that these studies highlight the importance of the endometrial environment for the maintenance of genetic stability and thus the propagation of specific genetic traits...
  83. ncbi Chromosome abnormality rates in human embryos obtained from in-vitro maturation and IVF treatment cycles
    Xiao Yun Zhang
    McGill Reproductive Centre, Department of Obstetrics and Gynecology, Royal Victoria Hospital, McGill University Health Center, Montreal, Quebec, Canada
    Reprod Biomed Online 21:552-9. 2010
    ....
  84. ncbi Circulating progesterone levels and ongoing pregnancy rates in controlled ovarian stimulation cycles for in vitro fertilization: analysis of over 4000 cycles
    E Bosch
    Department of Reproduction, Instituto Valenciano de Infertilidad, University of Valencia, Plaza de la Policia Local, 3, 46015 Valencia, Spain
    Hum Reprod 25:2092-100. 2010
    ..Efforts to resolve this question have been impeded by the various assays used to measure progesterone and the different, arbitrary threshold values for defining 'high' progesterone levels...
  85. ncbi A detailed cost analysis of in vitro fertilization and intracytoplasmic sperm injection treatment
    Clazien A M Bouwmans
    Institute for Medical Technology Assessment, Erasmus MC, University Medical Centre, Rotterdam, The Netherlands
    Fertil Steril 89:331-41. 2008
    ..To provide detailed information about costs of in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) treatment stages and to estimate the cost per IVF and ICSI treatment cycle and ongoing pregnancy...
  86. pmc Use of letrozole in assisted reproduction: a systematic review and meta-analysis
    Antonio Requena
    IVI Madrid, Santiago de Compostela 88, E 28035 Madrid, Spain
    Hum Reprod Update 14:571-82. 2008
    ..AIs induce ovulation by inhibiting estrogen production; the consequent hypoestrogenic state increases GnRH release and pituitary follicle-stimulating hormone (FSH) synthesis...
  87. ncbi Influence of well defined protein source on in vitro maturation of human oocyte: human follicular fluid versus human serum albumin
    Byung Chul Jee
    Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seongnam, Gyeonggi, Korea
    Fertil Steril 89:348-52. 2008
    ..To compare developmental competency of immature human oocytes matured in vitro in G2 media supplemented by two different protein sources...
  88. ncbi Putative predictors of antibodies against follicle-stimulating hormone in female infertility: a study based on in vitro fertilization patients
    Kadri Haller
    Department of Immunology, Institute of General and Molecular Pathology, Centre of Molecular and Clinical Medicine, University of Tartu, Biomedicum, Ravila Str 19, Tartu 50411, Estonia
    Am J Reprod Immunol 57:193-200. 2007
    ..Here, we investigated the parameters associated with anti-FSH antibodies in in vitro fertilization (IVF) patients...
  89. ncbi Serum antimüllerian hormone concentrations on day 3 of the in vitro fertilization stimulation cycle are predictive of the fertilization, implantation, and pregnancy in polycystic ovary syndrome patients undergoing assisted reproduction
    Cemil Kaya
    Department of Obstetrics and Gynecology, Faculty of Medicine, Ufuk University, Ankara, Turkey
    Fertil Steril 94:2202-7. 2010
    ..To determine the possible relationship between serum antimüllerian hormone (AMH) concentrations on day 3 and controlled ovarian stimulation and reproductive outcomes in women with polycystic ovary syndrome...
  90. ncbi Low-oxygen compared with high-oxygen atmosphere in blastocyst culture, a prospective randomized study
    Urban Waldenström
    In Vitro Fertilization Unit, Falun Hospital, Falun, Sweden
    Fertil Steril 91:2461-5. 2009
    ..To investigate birth rates with two oxygen (O(2)) concentrations in blastocyst culture...
  91. pmc Serum anti-Müllerian hormone predicts ovarian response and cycle outcome in IVF patients
    Cheng Hsuan Wu
    Department of Obstetrics and Gynecology, Changhua Christian Hospital, Changhua, 500 Taiwan, Republic of China
    J Assist Reprod Genet 26:383-9. 2009
    ..This prospective study was designed to investigate whether anti-Müllerian hormone (AMH) levels at basal and ovulation triggering day are associated with ovarian response and pregnancy outcome for in vitro fertilization (IVF)...
  92. ncbi Cryopreservation of human embryos by vitrification or slow freezing: a systematic review and meta-analysis
    Kalliopi E Loutradi
    Unit for Human Reproduction, 1st Department of Obstetrics and Gynaecology, Papageorgiou General Hospital, Thessaloniki, Greece
    Fertil Steril 90:186-93. 2008
    ..the literature systematically in order to identify prospective comparative trials answering the following question: Is vitrification of human embryos associated with a higher postthawing survival rate as compared with slow freezing?..
  93. ncbi Management of poor responders: can outcomes be improved with a novel gonadotropin-releasing hormone antagonist/letrozole protocol?
    William B Schoolcraft
    Colorado Center for Reproductive Medicine, Englewood, Colorado, USA
    Fertil Steril 89:151-6. 2008
    ..To compare the efficacy of a microdose GnRH agonist flare (ML) with a GnRH antagonist/letrozole (AL) protocol before IVF-ET in poor responders...
  94. ncbi Aromatase inhibitors for female infertility: a systematic review of the literature
    Nikolaos P Polyzos
    PACMeR Panhellenic Association for Continual Medical Research, Section of Obstetrics and Gynaecology and Public Health, Athens 10438, Greece
    Reprod Biomed Online 19:456-71. 2009
    ..If solid data from future large adequately powered randomized trials support current evidence regarding efficacy and safety, AI might offer a new treatment choice for infertile women...
  95. ncbi [Thromboembolic complications in patients undergoing in vitro fertilization: retrospective clinical study]
    M Mara
    Gynekologicko porodnická klinika 1 LF UK a VFN, Praha
    Ceska Gynekol 69:312-6. 2004
    ..To evaluate their clinical course, the influence on reproductive outcomes, and the prevalence of thrombophilia in these women...
  96. ncbi Investigation into effectiveness of counseling on assisted reproductive techniques in Turkey
    F Terzioglu
    Hacettepe University School of Nursing, Department of Obstetrics and Women s Health Nursing, Ankara, Turkey
    J Psychosom Obstet Gynaecol 22:133-41. 2001
    ....
  97. ncbi The endometrium in stimulated cycles for IVF
    Claire Bourgain
    Department of Pathology, University Hospital, Dutch Speaking Brussels Free University Vrije Universiteit Brussel, Laarbeeklaan 101, 1090 Brussels, Belgium
    Hum Reprod Update 9:515-22. 2003
    ..Further unravelling of molecules involved in the implantation mechanism is needed for a better comprehension of the link between altered endometrial development and receptivity in IVF cycles...
  98. ncbi Health of children born as a result of in vitro fertilization
    Reija Klemetti
    Health Services Research, National Research and Development Centre for Welfare and Health, Helsinki, Finland
    Pediatrics 118:1819-27. 2006
    ..The purpose of this study was to use nationwide registries to examine the health of children up to 4 years of age who were born as a result of in vitro fertilization...
  99. ncbi Sperm proteasome and fertilization
    Peter Sutovsky
    Division of Animal Sciences, Department of Obstetrics, Gynecology and Women s Health, University of Missouri Columbia, Columbia, Missouri 65211 5300, USA
    Reproduction 142:1-14. 2011
    ..Diagnostic and therapeutic applications could emerge in human reproductive medicine. Altogether, the studies on sperm proteasome indicate that animal fertilization is controlled in part by a unique, gamete associated, extracellular UPS...
  100. ncbi Effect of in vitro fertilization on gene expression and development of mouse preimplantation embryos
    Gnanaratnam Giritharan
    Department of Obstetric and Gynecology, University of California, San Francisco, San Francisco, California 94143, USA
    Reproduction 134:63-72. 2007
    ..Proliferation, apoptosis, and morphogenetic pathways are the most common pathways altered after IVC. Overall, IVF and embryo culture have a profound effect on gene expression pattern and phenotype of mouse preimplantation embryos...
  101. ncbi Ovarian stimulation by concomitant administration of cetrorelix acetate and HMG following Diane-35 pre-treatment for patients with polycystic ovary syndrome: a prospective randomized study
    Jiann Loung Hwang
    Department of Obstetrics and Gynecology, Shin Kong Wu Ho Su Memorial Hospital, Taipei, Taiwan
    Hum Reprod 19:1993-2000. 2004
    ..We proposed a stimulation protocol incorporating Diane-35 and GnRH antagonist (Diane/cetrorelix protocol) and compared it with the GnRH agonist long protocol for PCOS patients...

Research Grants67

  1. Analysis of epigenetic regulation in early mammalian embryos via RNA interference
    Charles R Long; Fiscal Year: 2010
    ....
  2. Cooperative Multicenter Reproductive Medicine Network (U10)
    MARCELLE IVONNE CEDARS; Fiscal Year: 2013
    ..In this proposal, drawing from studies of somatic aging, we propose a novel treatment to improve mitochondrial function and potentially reverse the age- associated decline in fertility...
  3. Trophoblast MHC-I: Trigger for Immune-Mediated Rejection of Cloned Bovine Fetuses
    Kenneth L White; Fiscal Year: 2011
    ....
  4. Response of Rhesus Sperm to Freezing: Recovery from Osmotic and Oxidative Stress
    Stuart A Meyers; Fiscal Year: 2010
    ....
  5. Paternal Environmental Exposures and Reproductive Outcomes: A Comparison of in Vi
    DEBORAH ANN HANSEN; Fiscal Year: 2013
    ..In vivo and in vitro parameters include: a) 14.5 dpc placental and fetal weights, and crown to rump lengths;b) full term litter size, birth weights, and 5 week growth rates;and c) gross and microscopic structure. ..
  6. Adverse Outcomes of Assisted Reproductive Technologies: Genetics or Epigenetics?
    Margareta Pisarska; Fiscal Year: 2013
    ....
  7. Early Identification of Developmental Disorders in Infants
    B Eugene Parker; Fiscal Year: 2012
    ....
  8. Stability of epigenetic structures in ART children
    Carmen Sapienza; Fiscal Year: 2010
    ..The incidence of abnormal epigenetic marks will be compared between the two populations to determine whether any aspect of the ART procedure results in destabilization of epigenetic structures in the genomes of early human embryos. ..
  9. The Utility of Empiric Medical Treatment of Infertile Oligo-asthenospermic Men
    Peter R Casson; Fiscal Year: 2013
    ..The potential benefits of this therapy are enormous: 1) reduced healthcare cost;2) improved pregnancy outcomes;and 3) improved quality of life for previously infertile couples. ..
  10. Microinjection Station for Utah Transgenic and Gene Targeting Mouse Core
    SUSAN JENIFER TAMOWSKI; Fiscal Year: 2010
    ..ICSI (intracytoplasmic sperm injection) is used to directly inject immobile sperm into an egg. This procedure is used if normal IVF or AIVF is unsuccessful. It is imperative that the injector have excellent optics in this procedure. ..
  11. Transgenerational effects of nicotine in F1 generation of exposed fathers in mice
    Markus Vallaster; Fiscal Year: 2013
    ..This will lead to new approaches in prevention and treatment of nicotine dependence and diseases linked to chronic nicotine exposure and its transgenerational inheritance. ..
  12. Cyclic AMP Action During Sperm Function
    George L Gerton; Fiscal Year: 2012
    ..Understanding the role of SACY during spermatogenesis in the testis, sperm maturation in the epididymis, and sperm capacitation will allow us to improve the efficacy of sperm becoming fertilization-competent. ..
  13. Non-invasive method to evaluate the quality of human oocytes and embryos
    XINGQI JOHN ZHANG; Fiscal Year: 2013
    ..improve the efficiency and efficacy of infertility treatments by identifying the most viable oocytes for fertilization in vitro, as well as exclusion of "bad embryos" for transfer...
  14. DNA Methylation: Structures, Functions, and Regulation
    Xiaodong Cheng; Fiscal Year: 2013
    ....
  15. Effects of Alcohol on Gene Expression & Epigenetics of Progeny
    CARRIE MARIN; Fiscal Year: 2009
    ....
  16. Molecular Mechanisms of Meiotic Maturation in Drosophila
    Daniela Drummond-Barbosa; Fiscal Year: 2013
    ..Our studies could potentially lead to additional therapies to address infertility, as well as to technological strategies to complement current in vitro fertilization methodology. ..
  17. The Role of Acid-active Hyaluronidases in Sperm Function
    PATRICIA ANASTASIA DELEON; Fiscal Year: 2010
    ..HYAL2 and 3, acidic hyases, are also expected to play a critical role in IVF and the recombinant proteins can now be used to advance assisted reproductive technology via their addition to the sperm surface, to treat sperm pathology. ..
  18. COOPERATIVE MULTICENTER REPRODUCTIVE MEDICINE NETWORK
    Christos Coutifaris; Fiscal Year: 2013
    ..The proposed clinical trial aims at markedly decreasing this undesired outcome taking advantage of recent advances that have resulted in embryos of high implantation potential...
  19. SIGNAL TRANSDUCTION AT FERTILIZATION
    Laurinda A Jaffe; Fiscal Year: 2012
    ..This research will advance knowledge of a crucial biological process, and establish a basis for future clinical developments, especially in the treatment of infertility. ..
  20. Improvement in Oocyte In Vitro Maturation (IVM) Using Microfluidic Culture
    ARTHUR GERSHOWITZ; Fiscal Year: 2010
    ..This system will make in vitro maturation a more effective, affordable and safer option for patients seeking assisted reproduction. ..
  21. Efficacy of Dexamethasone in Polycystic Ovary Syndrome Related Infertility
    Randal Robinson; Fiscal Year: 2013
    ....
  22. Sex Chromosomes in Fetal Programming and Susceptibility to EAE
    Cory Teuscher; Fiscal Year: 2010
    ....
  23. Long-term Follow-Up of Infertility Patients: A Pilot Study
    Francine Grodstein; Fiscal Year: 2010
    ..Thus, we propose to conduct a pilot study exploring the possibility of initiating research on infertility treatment in relation to long-term health within participants of the ongoing Nurses'Health Study II. ..
  24. 2011 Fertilization and Activation of Development Gordon Research Conference
    Janice P Evans; Fiscal Year: 2011
    ..Robert G. Edwards for the development of in vitro fertilization, a technique that is used to help the many couples who face struggles with infertility and has led to the birth of ~4 million individuals worldwide. ..
  25. Analysis of the gene networks regulating the maternal to zygotic transition
    ANTONIO GIRALDEZ; Fiscal Year: 2013
    ....
  26. Functional analysis of Cripto in mouse embryogenesis
    Michael M Shen; Fiscal Year: 2012
    ....
  27. Integrated Training in Reproductive Sciences
    Synthia H Mellon; Fiscal Year: 2013
    ..the interactiveness of the faculty, 3.) our substantial laboratory resources, and 4.) the outstanding environment for research in reproduction, development, endocrinology, cell biology, genetics and related areas at UCSF. ..
  28. Institute for Biogenesis Research: COBRE
    WILLIAM S WARD; Fiscal Year: 2012
    ..abstract_text> ..
  29. Families created by assisted reproduction: parenting and child development
    SUSAN ESTHER GOLOMBOK; Fiscal Year: 2011
    ..These samples are the first of their kind to be followed up from infancy, thus providing an opportunity to examine the influence of early experience on later development in these new family forms. ..
  30. Noninvasive assessment of embryo implantation potential using 1H NMR metabonomics
    Paolo Rinaudo; Fiscal Year: 2010
    ..We propose a pilot study to characterize the metabolic profile of implantable embryos from conditioned culture media using proton nuclear magnetic resonance spectroscopy (1H-NMR). ..
  31. IBR COBRE ADMINISTRATIVE CORE
    WILLIAM S WARD; Fiscal Year: 2011
    ..abstract_text> ..
  32. Function of RUNX transcription factors in COCs
    Misung Jo; Fiscal Year: 2013
    ....
  33. 2013 Fertilization and Activation of Development GRC/GRS
    PABLO EDUARDO VISCONTI; Fiscal Year: 2013
    ..This seminar has the objective to attract young investigators in the field of gamete research and fertilization. ..
  34. Rat sperm cryobanking for genetic resources
    Yuksel Agca; Fiscal Year: 2010
    ....
  35. Course and predictors of depressive relapse during IVF
    Marlene P Freeman; Fiscal Year: 2013
    ....
  36. An Izumo-Like Protein in C. elegans and its Role during Fertilization
    STEVEN W L'HERNAULT; Fiscal Year: 2012
    ..We will exploit the significant experimental advantages offered by nematodes for analyzing this important problem in reproductive biology. ..
  37. GENERATION OF AN INDUCIBLE SYSTEM IN THE UTERINE STROMA FOR IMPLANTATION STUDIES
    Liang Ma; Fiscal Year: 2013
    ..This mouse strain should be a valuable tool for researchers studying implantation as well as embryonic or postnatal organogenesis and carcinogenesis. ..
  38. Defects in Mitochondria Impacting Primate Oocyte Quality
    DAVID RANDALL ARMANT; Fiscal Year: 2010
    ..will be used: (i) assessment of mitochondrial localization profiles in oocytes before, during and after fertilization in vitro using multiphoton microscopy as a non-invasive analytical tool that provides 4-dimensional (4D) ..
  39. Soluble adenylyl cyclase isoforms essential for male fertility
    Lonny R Levin; Fiscal Year: 2013
    ..The studies proposed here may reveal unique aspects to the regulation of sperm cAMP signal transduction which could define a new target for contraceptive intervention. ..
  40. Assisted Reproductive Technologies and Increased Autism Risk
    PETER SHAWN BEARMAN; Fiscal Year: 2013
    ..This project has the potential to make significant contributions to our understanding of the etiology of autism as well as the long-term outcomes of ART births, neither of which are well understood. ..
  41. PYK2 function during fertilization
    William H Kinsey; Fiscal Year: 2013
    ..The specific role of PYK2 kinase in bringing the sperm nucleus into the egg will be analyzed with the ultimate aim of enhancing the success of human in vitro fertilization. ..
  42. Novel Informatics for Highly Reliable Multi-Locus Allele Calling for Embryo Scree
    Matthew Rabinowitz; Fiscal Year: 2009
    ..GSN's PS technology of will bring the domain of PGD into the realm of reliable diagnostics which can be regulated and used as part of the standard of care during in-vitro fertilization. ..
  43. New Mouse Mutation Exhibiting Failed Fertilization
    Mary Ann Handel; Fiscal Year: 2006
    ..The phenotype of the ferf1 mutation is breeding failure. Furthermore, during fertilization in vitro, sperm from affected males show abnormal agglutination and fail to fertilize zona pellucida-enclosed ..
  44. STEM CELL DERIVATION OF TWO NEOTROPICAL PRIMATE SPECIES
    A Michele Schuler; Fiscal Year: 2010
    ....
  45. Male Subfertility By Ni2+ Poisoning of Ca2+ Channels ?
    Susan Benoff; Fiscal Year: 2001
    ....
  46. Early Identification of Developmental Disorders in Infants
    B Parker; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  47. REGULATION AND FUNCTION OF SPARC IN MALE REPRODUCTION
    Robert Vernon; Fiscal Year: 1991
    ..These experiments focus on a well-characterized molecule whose function and genetic regulation will be examined during testicular development and spermatogenesis...
  48. CENTROSOME DEFECTS AS CAUSES OF MALE INFERTILITY
    Gerald Schatten; Fiscal Year: 1999
    ..sperm with defective centrosomes from infertile men are unable to complete fertilization in vitro; and xiii. these approaches might be developed into reliable assays for male infertility...
  49. FLUORESCENCE-BASED STUDIES OF SPHINGOMYELIN AND CERAMIDE
    EDWARD SCHUCHMAN; Fiscal Year: 2002
    ..abstract_text> ..
  50. PGD: Couples Decision Making at the Genetic and Reproductive Interface
    Patricia Hershberger; Fiscal Year: 2009
    ....
  51. A CAROLINA CENTER TO CHARACTERIZE &MAINTAIN MUTANT MICE: AIDS
    Terry Magnuson; Fiscal Year: 2011
    ..abstract_text> ..
  52. Comprehensive aneuploidy diagnosis in single cells
    Nury Steuerwald; Fiscal Year: 2005
    ..The detection and avoidance of all aneuploid oocytes will lead to improved IVF outcomes for thousands of patients. Multiple births might also be reduced a s increased IVF success rates mean that fewer embryos need be transferred. ..
  53. Maternal Pesticide Exposure and Pregnancy Outcomes
    Russ Hauser; Fiscal Year: 2009
    ..Since the etiology of infertility and early pregnancy loss remains largely unexplained, the identification of potential environmental risk factors will have large public health significance. ..
  54. Full karyotype single cell interphase analysis
    Santiago Munne; Fiscal Year: 2005
    ..In phase-I we propose to develop two of the three sets of probes, and to test that these probes will work with 90% efficiency after three rounds of hybridization in single polar bodies. ..
  55. YOUNG FROM STORED AND IMPAIRED MOUSE SPERM
    John Biggers; Fiscal Year: 2001
    ..Other studies will be concerned with improving the current methods of in vitro fertilization, intracytoplasmic sperm injection and embryo transfer in mice, the results of which will be incorporated in a final algorithm. ..
  56. Paracrine dysregulation of oocyte competence in PCOS
    DANIEL DUMESIC; Fiscal Year: 2006
    ..abstract_text> ..
  57. Improved Implantation and Pregnancy Using Microfluidic Embryo Culture
    Xiaoyue Zhu; Fiscal Year: 2007
    ..This project will advance current technologies that provide near physiologic conditions to improve the developmental rate and cell formation for early stage embryos. [unreadable] [unreadable] [unreadable]..
  58. A Carolina Center to Characterize and Maintain Mutant Mice
    Terry Magnuson; Fiscal Year: 2013
    ..The MMRRC imports, archives and distributes these important mutant strains to the scientific community for addressing the genetics underlying human disease conditions. ..
  59. CONVENTIONAL INFERTILITY THERAPY VS FAST TRACK TO IVF
    Richard Reindollar; Fiscal Year: 2004
    ..2) Because insurance coverage for infertility is required by Massachusetts law for all participants, the choice of therapeutic alternatives is not affected by the patients' ability to pay for treatment. ..
  60. Late Parenting & Biotechnology: Rethinking Age, Gender, Family, & the Life Course
    ROBERT DAVID NACHTIGALL; Fiscal Year: 2010
    ..Single participants will also be interviewed twice. Qualitative data analysis wins then proceed in a seven-step progression. ..
  61. ICE-FREE PRESERVATION OF OVARIES FOR LONG-TERM FECUNDITY
    Ying Song; Fiscal Year: 2004
    ....
  62. SAGE Analysis of Murine Oocyte Maturation
    CHARLOTTE FARIN; Fiscal Year: 2004
    ..Differential expression of the candidate gene sequences will be verified using reverse transcription-polymerase chain reaction (RT-PCR). ..
  63. SPERM PROGESTERONE RECEPTOR, K+ CHANNEL & PB EXPOSURE
    Asha Jacob; Fiscal Year: 1999
    ..They will determine the stage-specific expression of the human sperm K+ channel by in situ RT/PCR on human testes biopsy sections. ..
  64. ABNORMALITIES IN CALVES FROM EMBRYO TRANSFER
    George Seidel; Fiscal Year: 1980
    ..Such information is essential for making informed decisions concerning experimental or clinical application of superovulation and transfer of human embryos and for predicting the consequences of using fertility drugs...
  65. Advanced Reproductive Technology and Infant Health
    Marianne Bitler; Fiscal Year: 2005
    ..This research will extend these preliminary studies to look at all births, and to look at additional outcomes such as infant mortality. ..
  66. Reversal of Infertility in Ovarian Failure
    Ayman Al Hendy; Fiscal Year: 2006
    ..Gene therapy is a rapidly developing field and may be a useful tool in treating several conditions in the area of women health that currently have no effective treatment available. ..
  67. STUDIES ON SPERM FERTILIZING ABILITY
    Barry Bavister; Fiscal Year: 1993
    ..The results of these experiments will provide deeper insights into the functional roles of these naturally-occurring factors, and into their mechanisms of action in regulating events immediately preceding egg penetration...