embryo transfer

Summary

Summary: The transfer of mammalian embryos from an in vivo or in vitro environment to a suitable host to improve pregnancy or gestational outcome in human or animal. In human fertility treatment programs, preimplantation embryos ranging from the 4-cell stage to the blastocyst stage are transferred to the uterine cavity between 3-5 days after FERTILIZATION IN VITRO.

Top Publications

  1. ncbi Epigenetic instability in ES cells and cloned mice
    D Humpherys
    Whitehead Institute for Biomedical Research, Department of Biology, Massachusetts Institute of Technology, 9 Cambridge Center, Cambridge MA 02142, USA
    Science 293:95-7. 2001
  2. ncbi Viable offspring derived from fetal and adult mammalian cells
    I Wilmut
    Roslin Institute Edinburgh, Roslin, Midlothian, UK
    Nature 385:810-3. 1997
  3. ncbi Blastocyst biopsy with comprehensive chromosome screening and fresh embryo transfer significantly increases in vitro fertilization implantation and delivery rates: a randomized controlled trial
    Richard T Scott
    Reproductive Medicine Associates of New Jersey, Morristown, New Jersey, USA
    Fertil Steril 100:697-703. 2013
  4. ncbi Assisted reproductive technology in Europe, 2006: results generated from European registers by ESHRE
    J de Mouzon
    ESHRE Central Office, Meerstraat 60, B 1852 Grimbergen, Belgium
    Hum Reprod 25:1851-62. 2010
  5. ncbi Birth after the reimplantation of a human embryo
    P C Steptoe
    Lancet 2:366. 1978
  6. ncbi Eight-hydroxy-2'-deoxyguanosine in granulosa cells is correlated with the quality of oocytes and embryos in an in vitro fertilization-embryo transfer program
    Tomofumi Seino
    Department of Obstetrics and Gynecology, Yamagata University School of Medicine, Yamagata, Japan
    Fertil Steril 77:1184-90. 2002
  7. ncbi Bovine pretransfer endometrium and embryo transcriptome fingerprints as predictors of pregnancy success after embryo transfer
    Dessie Salilew-Wondim
    Institute of Animal Science, Animal Breeding and Husbandry Group, University of Bonn, Endenicher Allee 15, Bonn, Germany
    Physiol Genomics 42:201-18. 2010
  8. ncbi Perinatal outcome of children born after frozen and fresh embryo transfer: the Finnish cohort study 1995-2006
    S Pelkonen
    Department of Obstetrics and Gynecology, Oulu University Hospital, PO Box 24, FIN 90029 Oulu, Finland
    Hum Reprod 25:914-23. 2010
  9. ncbi Highly efficient vitrification method for cryopreservation of human oocytes
    Masashige Kuwayama
    Kato Ladies Clinic, Tokyo, Japan
    Reprod Biomed Online 11:300-8. 2005
  10. pmc Effects of acupuncture on rates of pregnancy and live birth among women undergoing in vitro fertilisation: systematic review and meta-analysis
    Eric Manheimer
    Center for Integrative Medicine, University of Maryland School of Medicine, 2200 Kernan Drive, Kernan Hospital Mansion, Baltimore, MD 21207, USA
    BMJ 336:545-9. 2008

Research Grants

Detail Information

Publications384 found, 100 shown here

  1. ncbi Epigenetic instability in ES cells and cloned mice
    D Humpherys
    Whitehead Institute for Biomedical Research, Department of Biology, Massachusetts Institute of Technology, 9 Cambridge Center, Cambridge MA 02142, USA
    Science 293:95-7. 2001
    ..These data imply that even apparently normal cloned animals may have subtle abnormalities in gene expression...
  2. ncbi Viable offspring derived from fetal and adult mammalian cells
    I Wilmut
    Roslin Institute Edinburgh, Roslin, Midlothian, UK
    Nature 385:810-3. 1997
    ....
  3. ncbi Blastocyst biopsy with comprehensive chromosome screening and fresh embryo transfer significantly increases in vitro fertilization implantation and delivery rates: a randomized controlled trial
    Richard T Scott
    Reproductive Medicine Associates of New Jersey, Morristown, New Jersey, USA
    Fertil Steril 100:697-703. 2013
    ..To determine whether blastocyst biopsy and rapid quantitative real-time polymerase chain reaction (qPCR)-based comprehensive chromosome screening (CCS) improves in vitro fertilization (IVF) implantation and delivery rates...
  4. ncbi Assisted reproductive technology in Europe, 2006: results generated from European registers by ESHRE
    J de Mouzon
    ESHRE Central Office, Meerstraat 60, B 1852 Grimbergen, Belgium
    Hum Reprod 25:1851-62. 2010
    ..In this 10th European IVF-monitoring (EIM) report, the results of assisted reproductive techniques from treatments initiated in Europe during 2006 are presented. Data were mainly collected from existing national registers...
  5. ncbi Birth after the reimplantation of a human embryo
    P C Steptoe
    Lancet 2:366. 1978
  6. ncbi Eight-hydroxy-2'-deoxyguanosine in granulosa cells is correlated with the quality of oocytes and embryos in an in vitro fertilization-embryo transfer program
    Tomofumi Seino
    Department of Obstetrics and Gynecology, Yamagata University School of Medicine, Yamagata, Japan
    Fertil Steril 77:1184-90. 2002
    To determine the effects of oxidative stress on the quality of oocytes and embryos, 8-hydroxy-2'-deoxyguanosine (8-OHdG) in granulosa cells was quantitatively studied during an in vitro fertilization and embryo transfer (IVF-ET) program.
  7. ncbi Bovine pretransfer endometrium and embryo transcriptome fingerprints as predictors of pregnancy success after embryo transfer
    Dessie Salilew-Wondim
    Institute of Animal Science, Animal Breeding and Husbandry Group, University of Bonn, Endenicher Allee 15, Bonn, Germany
    Physiol Genomics 42:201-18. 2010
    ..samples were collected from Simmental heifers at day 7 and 14 of the estrous cycle, one cycle prior to embryo transfer. In the next cycle, blastocyst stage embryos were transferred to recipients at day 7 of the estrous cycle ..
  8. ncbi Perinatal outcome of children born after frozen and fresh embryo transfer: the Finnish cohort study 1995-2006
    S Pelkonen
    Department of Obstetrics and Gynecology, Oulu University Hospital, PO Box 24, FIN 90029 Oulu, Finland
    Hum Reprod 25:914-23. 2010
    The number of children born after frozen embryo transfer (FET) is steadily rising. However, studies on obstetric and perinatal outcomes are limited...
  9. ncbi Highly efficient vitrification method for cryopreservation of human oocytes
    Masashige Kuwayama
    Kato Ladies Clinic, Tokyo, Japan
    Reprod Biomed Online 11:300-8. 2005
    ..The results suggest that vitrification using the Cryotop is the most efficient method for human oocyte cryopreservation...
  10. pmc Effects of acupuncture on rates of pregnancy and live birth among women undergoing in vitro fertilisation: systematic review and meta-analysis
    Eric Manheimer
    Center for Integrative Medicine, University of Maryland School of Medicine, 2200 Kernan Drive, Kernan Hospital Mansion, Baltimore, MD 21207, USA
    BMJ 336:545-9. 2008
    To evaluate whether acupuncture improves rates of pregnancy and live birth when used as an adjuvant treatment to embryo transfer in women undergoing in vitro fertilisation.
  11. ncbi Blastocyst score affects implantation and pregnancy outcome: towards a single blastocyst transfer
    D K Gardner
    Colorado Center for Reproductive Medicine, Englewood, Colorado, USA
    Fertil Steril 73:1155-8. 2000
    ..To determine the relationship between blastocyst score and pregnancy outcome...
  12. ncbi Comparison of concomitant outcome achieved with fresh and cryopreserved donor oocytes vitrified by the Cryotop method
    Ana Cobo
    IVI Universidad de Valencia, Valencia, Spain
    Fertil Steril 89:1657-64. 2008
    ..To evaluate the outcome of oocyte vitrification using the Cryotop method, observed in an egg donation program by simultaneously evaluating embryos derived from vitrified and fresh oocytes coming from the same stimulated cycle...
  13. ncbi Progesterone rise on the day of human chorionic gonadotropin administration impairs pregnancy outcome in day 3 single-embryo transfer, while has no effect on day 5 single blastocyst transfer
    Evangelos G Papanikolaou
    Centre for Reproductive Medicine, University Hospital, Vrije Univestiteit Brussel, Free University of Brussels, Brussels, Belgium
    Fertil Steril 91:949-52. 2009
    ..On the contrary, premature luteinization in the blastocyst subgroup had no effect on the pregnancy outcome...
  14. ncbi Noninvasive metabolomic profiling of embryo culture media using Raman and near-infrared spectroscopy correlates with reproductive potential of embryos in women undergoing in vitro fertilization
    Emre Seli
    Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520 8063, USA
    Fertil Steril 88:1350-7. 2007
    ..To determine if metabolomic profiling of embryo culture media correlates with reproductive potential of individual embryos...
  15. ncbi Metabolomic profiling by near-infrared spectroscopy as a tool to assess embryo viability: a novel, non-invasive method for embryo selection
    C G Vergouw
    Department of Obstetrics, Gynaecology and Reproductive Medicine, VU University Medical Center, Amsterdam, The Netherlands
    Hum Reprod 23:1499-504. 2008
    ..and ongoing pregnancy, therefore new selection tools are needed to maintain success rates with single-embryo transfer (SET)...
  16. ncbi Vitrification of human blastocysts with the Hemi-Straw carrier: application of assisted hatching after thawing
    P Vanderzwalmen
    Schoysman Infertility Management Foundation, AZ Jan Portaels, Gendarmeriestraat 65, 1800 Vilvoorde, Belgium
    Hum Reprod 18:1504-11. 2003
    ..The present study was undertaken to examine the usefulness of both vitrification and assisted hatching (AH) on blastocysts that originate from embryos showing different qualities during their cleavage stage...
  17. ncbi Selection of patients suitable for one-embryo transfer may reduce the rate of multiple births by half without impairment of overall birth rates
    A Strandell
    Department of Obstetrics and Gynaecology, Sahlgrenska University Hospital, Goteborg, Sweden
    Hum Reprod 15:2520-5. 2000
    ..was to identify a subset of patients at high risk of multiple birth after IVF and hence suitable for one-embryo transfer, which undoubtedly would reduce the multiple birth rate...
  18. pmc Embryo quality, blastocyst and ongoing pregnancy rates in oocyte donation patients whose embryos were monitored by time-lapse imaging
    Maria Cruz
    Instituto Valenciano de Infertilidad, Alicante, Spain
    J Assist Reprod Genet 28:569-73. 2011
    ..We analyzed 478 embryos from 60 couples undergoing oocyte donation were included in the study...
  19. ncbi Successful nonsurgical deep uterine embryo transfer in pigs
    Emilio A Martinez
    Department of Medicine and Animal Surgery, University of Murcia, 30071, Spain
    Theriogenology 61:137-46. 2004
    ..The aim of this study was to develop a procedure for nonsurgical embryo transfer (ET) into the upper part of one uterine horn in gilts and sows...
  20. pmc Conserving, distributing and managing genetically modified mouse lines by sperm cryopreservation
    G Charles Ostermeier
    Technology Evaluation and Development, The Jackson Laboratory, Bar Harbor, Maine, United States of America
    PLoS ONE 3:e2792. 2008
    ..Sperm from C57BL/6 mice are difficult to cryopreserve and recover. Yet, the majority of genetically modified (GM) lines are maintained on this genetic background...
  21. ncbi Fresh embryo transfer versus frozen embryo transfer in in vitro fertilization cycles: a systematic review and meta-analysis
    Matheus Roque
    Máster Internacional Medicina Reproductiva, Hospital del Mar, Barcelona, Spain
    Fertil Steril 99:156-62. 2013
    To examine the available evidence to assess if cryopreservation of all embryos and subsequent frozen embryo transfer (FET) results in better outcomes compared with fresh transfer.
  22. pmc Impact of follicular G-CSF quantification on subsequent embryo transfer decisions: a proof of concept study
    N Ledee
    INSERM, U976, F 75475 Paris, France
    Hum Reprod 28:406-13. 2013
    ..Here we present a proof of concept study aimed at evaluating the impact of including FF G-CSF quantification in the embryo transfer decisions.
  23. pmc Lessons from elective in vitro fertilization (IVF) in, principally, non-infertile women
    Norbert Gleicher
    Center for Human Reproduction, New York, NY 10021, USA
    Reprod Biol Endocrinol 10:48. 2012
    ..Since IVF outcome in women with infertility are always influenced by underlying causes of infertility, a study on non-infertile women may offer new insights...
  24. ncbi Cleavage stage versus blastocyst stage embryo transfer in assisted reproductive technology
    Demian Glujovsky
    Reproductive Medicine, CEGYR Centro de Estudios en Ginecologia y Reproduccion, Buenos Aires, Argentina
    Cochrane Database Syst Rev 7:CD002118. 2012
    ..Advances in cell culture media have led to a shift in in vitro fertilization (IVF) practice from early cleavage embryo transfer to blastocyst stage transfer...
  25. pmc Time-lapse evaluation of human embryo development in single versus sequential culture media--a sibling oocyte study
    Haydar Nadir Ciray
    Fulya IVF Clinic, Bahceci Health Group, Hakki Yeten cd 11, Terrace Fulya, Istanbul, Turkey
    J Assist Reprod Genet 29:891-900. 2012
    ..To compare the dynamics of early development between embryos cultured in single and sequential media...
  26. ncbi Increased risk of preterm birth in singleton pregnancies after blastocyst versus Day 3 embryo transfer: Canadian ART Register (CARTR) analysis
    S Dar
    CReATe Fertility Center, 790 Bay Street, Suite 1100, Toronto, Ontario, Canada M5G 1N8
    Hum Reprod 28:924-8. 2013
    Are the fetal outcomes of singleton pregnancies that result from cleavage stage embryo transfer (ET) different from the outcomes from Day 5/6 blastocyst stage ET?
  27. pmc Relationship between antithyroid antibody and pregnancy outcome following in vitro fertilization and embryo transfer
    Yi Ping Zhong
    Reproductive Medicine Center, the First Affiliated Hospital of Sun Yat Sen University, Guangzhou 510080, China
    Int J Med Sci 9:121-5. 2012
    To investigate the impact of antithyroid antibody on pregnancy outcome following the in vitro fertilization and embryo transfer (IVF-ET).
  28. ncbi International Committee for Monitoring Assisted Reproductive Technologies (ICMART) world report: assisted reproductive technology 2004
    E A Sullivan
    National Perinatal Statistics and Epidemiology Unit, School of Women s and Children s Health, University of New South Wales, Randwick Hospitals Campus, McNevin Dickson Building Room Level 2, Randwick, NSW 2031, Australia
    Hum Reprod 28:1375-90. 2013
    ..Have changes in assisted reproductive technology (ART) practice and outcomes occurred globally between 2003 and 2004?..
  29. ncbi The endometrium in stimulated cycles for IVF
    Claire Bourgain
    Department of Pathology, University Hospital, Dutch Speaking Brussels Free University Vrije Universiteit Brussel, Laarbeeklaan 101, 1090 Brussels, Belgium
    Hum Reprod Update 9:515-22. 2003
    ..Studies exploring the endometrium within the cycle of embryo transfer have shown a deleterious effect of severe peri-ovulatory maturation advancement exceeding 3 days, as no ..
  30. ncbi Bovine fetal microchimerism in normal and embryo transfer pregnancies and its implications for biotechnology applications in cattle
    Lauretta Turin
    Dipartimento di Patologia Animale, Igiene e Sanita Pubblica Veterinaria, Universita degli Studi di Milano, Milano, Italy
    Biotechnol J 2:486-91. 2007
    ....
  31. ncbi Somatic cell nuclear reprogramming of mouse oocytes endures beyond reproductive decline
    Telma Cristina Esteves
    Max Planck Institute for Molecular Biomedicine, Röntgenstrasse 20, D 48149 Munster, Germany
    Aging Cell 10:80-95. 2011
    ....
  32. ncbi Factors predicting the cumulative outcome of IVF/ICSI treatment: a multivariable analysis of 2450 patients
    Q F Cai
    Reproductive Medicine Center, Women and Children s Hospital of Guangdong Province, Guangzhou 510000, PR China
    Hum Reprod 26:2532-40. 2011
    ....
  33. ncbi What is the preferred GnRH analogue for polycystic ovary syndrome patients undergoing controlled ovarian hyperstimulation for in vitro fertilization?
    Raoul Orvieto
    Department of Obstetrics and Gynecology, Barzilai Medical Center, Ashkelon, Israel
    Fertil Steril 91:1466-8. 2009
    ..The PCOS patients undergoing COH using the GnRH agonist protocol (n = 50) showed a significantly higher pregnancy rate (36% vs. 19.6%, respectively), compared with the GnRH antagonist protocol (n = 102)...
  34. ncbi The use of morphokinetics as a predictor of embryo implantation
    Marcos Meseguer
    Instituto Valenciano de Infertilidad, Universidad de Valencia, Plaza de la Policia Local, 3, Valencia 46015, Spain
    Hum Reprod 26:2658-71. 2011
    ..In order to compare a large number of embryos, with minimal variation in culture conditions, we have used an automatic embryo monitoring system...
  35. ncbi Hormonal induction of endometrial receptivity
    Richard J Paulson
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Keck School of Medicine of the University of Southern California, Los Angeles, CA 90033, USA
    Fertil Steril 96:530-5. 2011
    ..To review and synthesize information from the scientific literature pertaining to the hormonal induction of endometrial receptivity before ET...
  36. ncbi Noninvasive metabolomic profiling of embryo culture media using proton nuclear magnetic resonance correlates with reproductive potential of embryos in women undergoing in vitro fertilization
    Emre Seli
    Department of Obstetrics, Yale University School of Medicine, New Haven, Connecticut 06511, USA
    Fertil Steril 90:2183-9. 2008
    ..To identify biomarkers associated with reproductive outcome using proton nuclear magnetic resonance ((1)H NMR) metabolomic profiling of embryo culture media...
  37. ncbi Faithful expression of imprinted genes in cloned mice
    Kimiko Inoue
    Department of Veterinary Science, National Institute of Infectious Diseases, 1 23 1, Toyama, Shinjuku, Tokyo 162 8640, Japan
    Science 295:297. 2002
  38. ncbi Understanding maternal contributions to fertility in recipient cattle: development of herds with contrasting pregnancy rates
    W H McMillan
    AgResearch Ruakura, Hamilton, New Zealand
    Anim Reprod Sci 57:127-40. 1999
    ..These sub-herds are a unique experimental resource for understanding the early pregnancy process in cattle...
  39. ncbi Dogs cloned from adult somatic cells
    Byeong Chun Lee
    Department of Theriogenology and Biotechnology, College of Veterinary Medicine, Seoul National University, Gwanak Gu, Seoul 151 742, South Korea
    Nature 436:641. 2005
    ....
  40. ncbi Mouse cloning with nucleus donor cells of different age and type
    T Wakayama
    Department of Anatomy and Reproductive Biology, University of Hawaii, School of Medicine, Honolulu, Hawaii, USA
    Mol Reprod Dev 58:376-83. 2001
    ..This may largely be due to technical problems and/or problems of genomic reprogramming by oocytes rather than the accumulation of mutational damage in adult somatic cells...
  41. ncbi Effect of dehydroepiandrosterone on oocyte and embryo yields, embryo grade and cell number in IVF
    David Barad
    Center for Human Reproduction, New York, NY, USA
    Hum Reprod 21:2845-9. 2006
    ..The aim of this study was to investigate the effect of treatment with dehydroepiandrosterone (DHEA) on fertility outcomes among women with diminished ovarian reserve...
  42. ncbi Clinical outcome of oocyte cryopreservation after slow cooling with a protocol utilizing a high sucrose concentration
    A Borini
    Tecnobios Procreazione, Via Dante 15 University of Bologna, 40125 Bologna, Italy
    Hum Reprod 21:512-7. 2006
    ..However, the clinical efficiency of these protocols has not been exhaustively explored and therefore remains controversial...
  43. ncbi Effect of polychlorinated biphenyls (PCBs) and 1,1,1-trichloro-2,2,-bis (4-chlorophenyl)-ethane (DDT) in follicular fluid on the results of in vitro fertilization-embryo transfer (IVF-ET) programs
    Simona Jirsová
    Department of Gynecology and Obstetrics, Charles University, First Faculty of Medicine and General Teaching Hospital, Prague, Czech Republic
    Fertil Steril 93:1831-6. 2010
    ..To establish the effect of chlorinated organic compounds on fertility...
  44. ncbi Assisted reproductive technology in Europe, 2001. Results generated from European registers by ESHRE
    A Nyboe Andersen
    Hum Reprod 20:1158-76. 2005
    ..From 23 countries, 579 clinics reported 289 690 cycles with: IVF 120 946, ICSI 114 378, frozen embryo transfer (FER) 47 195 and egg donation (ED) 7171. Overall this represents a 4% increase since the year 2000...
  45. ncbi Live birth after polar body array comparative genomic hybridization prediction of embryo ploidy-the future of IVF?
    Simon Fishel
    CARE Fertility, John Webster House, 6 Lawrence Drive, Nottingham Business Park, Nottingham NG8 6PZ, United Kingdom
    Fertil Steril 93:1006.e7-1006.e10. 2010
    ..aneuploidy of the human egg using array comparative genomic hybridization to evaluate the 23-paired chromosome copy number of first polar body as an objective prognosticator of embryo viability for embryo transfer in the same cycle.
  46. ncbi Predictive factors in in vitro fertilization (IVF): a systematic review and meta-analysis
    L L van Loendersloot
    Department of Obstetrics and Gynaecology, Centre for Reproductive Medicine, Meibergdreef 9, Amsterdam, The Netherlands
    Hum Reprod Update 16:577-89. 2010
    ..These models differ from one another in the predictors they include. We performed a systematic review and meta-analysis to identify the most relevant predictors for success in IVF...
  47. ncbi Production of cloned calves following nuclear transfer with cultured adult mural granulosa cells
    D N Wells
    AgResearch, Ruakura Research Centre, PB 3123, Hamilton, New Zealand
    Biol Reprod 60:996-1005. 1999
    ..The next advance in this technology will be to introduce specific genetic modifications of biomedical or agricultural interest...
  48. ncbi Cytokines and chemokines in follicular fluids and potential of the corresponding embryo: the role of granulocyte colony-stimulating factor
    N Ledee
    Service de Gynécologie Obstétrique et Médecine de la Reproduction et Service de cytogenétique et Biologie de la Reproduction, centre hospitalier intercommunal Poissy Saint Germain en Laye, Univ UVSQ, UPRES EA 2493, Poissy, France
    Hum Reprod 23:2001-9. 2008
    ..The cytokine/chemokine levels of individual follicular fluids (FFs) were measured to determine whether a biomarker could be linked to the developmental potential of the derived embryo...
  49. ncbi Limited value of morphological assessment at days 1 and 2 to predict blastocyst development potential: a prospective study based on 4042 embryos
    F Guerif
    Service de Médecine et Biologie de la Reproduction, CHU Bretonneau, 2 boulevard Tonnelle, 37000 Tours, France
    Hum Reprod 22:1973-81. 2007
    ..Non-invasive and routine developmental markers are available to select the most viable embryo; however their respective values in terms of blastocyst development potential remain difficult to distinguish...
  50. ncbi A randomized double blind comparison of real and placebo acupuncture in IVF treatment
    Emily Wing Sze So
    Department of Obstetrics and Gynaecology, The University of Hong Kong, Hong Kong Special Administrative Region, Pokfulam Road, Hong Kong, People s Republic of China
    Hum Reprod 24:341-8. 2009
    ..This randomized double blind study aimed to compare real acupuncture with placebo acupuncture in patients undergoing IVF treatment...
  51. ncbi A randomized single-blind controlled trial of letrozole as a low-cost IVF protocol in women with poor ovarian response: a preliminary report
    S K Goswami
    Institute of Reproductive Medicine, Salt Lake, Kolkata 700091, India
    Hum Reprod 19:2031-5. 2004
    ..Use of letrozole, a selective inhibitor of aromatase, reduces the gonadotrophin dose required to induce follicular maturation. We evaluated whether incorporation of letrozole could be an effective low-cost IVF protocol for poor responders...
  52. ncbi Cryopreservation of human embryos by vitrification or slow freezing: a systematic review and meta-analysis
    Kalliopi E Loutradi
    Unit for Human Reproduction, 1st Department of Obstetrics and Gynaecology, Papageorgiou General Hospital, Thessaloniki, Greece
    Fertil Steril 90:186-93. 2008
    ..the literature systematically in order to identify prospective comparative trials answering the following question: Is vitrification of human embryos associated with a higher postthawing survival rate as compared with slow freezing?..
  53. ncbi A QTL study of cattle behavioral traits in embryo transfer families
    S M Schmutz
    Department of Animal and Poultry Science, University of Saskatchewan, Saskatoon, Canada
    J Hered 92:290-2. 2001
    ..36 for temperament and 0.46 for habituation. Genotyping of 162 microsatellites at approximately 20 cM intervals allowed the detection of six quantitative trait loci (QTL) for behavior traits on cattle chromosomes 1, 5, 9, 11, 14, 15...
  54. pmc Pregnancy prediction models and eSET criteria for IVF patients--do we need more information?
    Lars D M Ottosen
    The Fertility Clinic, Department of Obstetrics and Gynaecology, Aarhus University Hospital, Skejby Sygehus, Brendstrupgaardsvej, DK 8200, Arhus N, Denmark
    J Assist Reprod Genet 24:29-36. 2007
    ..The purpose of the present study was to evaluate statistical prediction models and simple allocation criteria, based on predictors for pregnancy, as tools to identify a good prognosis group in a possible eSET setting...
  55. pmc Do polymorphic variants of chromosomes affect the outcome of in vitro fertilization and embryo transfer treatment?
    Y Hong
    Department of Reproductive Medicine, RenJi Hospital of Shanghai Jiaotong University, Shanghai 200001, China
    Hum Reprod 26:933-40. 2011
    ..of this study was to investigate the effect of chromosomal polymorphic variations on the outcome of IVF and embryo transfer (IVF-embryo transfer) treatment for infertile couples...
  56. ncbi Working to eliminate multiple pregnancies: a success story in Québec
    F Bissonnette
    OVO Fertility, Montreal, Quebec, Canada
    Reprod Biomed Online 23:500-4. 2011
    ..performed in five Québec assisted reproduction centres, with an overall clinical pregnancy rate of 32% per embryo transfer and 50% of transfers used elective single-embryo transfer (eSET). The multiple-pregnancy rate was only 3...
  57. ncbi Application of vitrification to human embryo freezing
    H Saito
    Department of Obstetrics and Gynecology, Yamagata University School of Medicine, Yamagata, Japan
    Gynecol Obstet Invest 49:145-9. 2000
    To solve the problem of multiple pregnancies during the in vitro fertilization (IVF) and embryo transfer procedure, excess embryos must be cryopreserved for embryo transfer in future...
  58. pmc Embryo morphology score on day 3 is predictive of implantation and live birth rates
    Sara J Dennis
    Center for Reproductive Health, University of Cincinnati, Cincinnati, Ohio, USA
    J Assist Reprod Genet 23:171-5. 2006
    ..To determine if embryo cleavage state or morphology on day 3 correlates with implantation or live birth rates. A retrospective cohort study of all fresh embryo transfers over 2 years...
  59. ncbi Genomic imprinting is a barrier to parthenogenesis in mammals
    T Kono
    Department of Bioscience, Tokyo University of Agriculture, Tokyo, Japan
    Cytogenet Genome Res 113:31-5. 2006
    ..The resulting ng (non-growing)/fg (fully-grown) parthenogenic embryos were developed to term. Here, we discuss how the parthenogenetic embryos survived as normal individuals...
  60. ncbi Intrauterine injection of human chorionic gonadotropin before embryo transfer significantly improves the implantation and pregnancy rates in in vitro fertilization/intracytoplasmic sperm injection: a prospective randomized study
    Ragaa Mansour
    The Egyptian IVF ET Center, Cairo, Egypt
    Fertil Steril 96:1370-1374.e1. 2011
    To investigate the value of intrauterine injection of human chorionic gonadotropin (hCG) before embryo transfer (ET).
  61. pmc Clinical benefit of metaphase I oocytes
    Leen Vanhoutte
    Infertility Centre, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium
    Reprod Biol Endocrinol 3:71. 2005
    ..We studied the benefit of using in vitro matured metaphase I (MI) oocytes for ICSI in patients with a maximum of 6 mature metaphase II (MII) oocytes at retrieval...
  62. ncbi Performance of ten inbred mouse strains following assisted reproductive technologies (ARTs)
    Shannon L Byers
    Theriogenology 65:1716-26. 2006
    Superovulation, in vitro fertilization, embryo cryopreservation, and embryo transfer are assisted reproductive technologies (ARTs) widely used in laboratory mice...
  63. ncbi Novel universal approach for preimplantation genetic diagnosis of beta-thalassaemia in combination with HLA matching of embryos
    H Van de Velde
    Centre for Reproductive Medicine, Brussels, Belgium
    Hum Reprod 19:700-8. 2004
    ..Furthermore, healthy embryos could be HLA matched with the affected child so that cord blood from the future newborn can be used to transplant the affected sibling...
  64. ncbi Where does the embryo implant after embryo transfer in humans?
    K Baba
    Department of Obstetrics and Gynecology, Saitama Medical Center, Saitama Medical School, Kawagoe, Japan
    Fertil Steril 73:123-5. 2000
    ..To investigate where human embryos implant after ET...
  65. ncbi Elevated serum progesterone level on the day of human chorionic gonadotropin administration does not adversely affect implantation rates after intracytoplasmic sperm injection and embryo transfer
    B Urman
    Assisted Reproduction Unit, American Hospital of Istanbul, Turkey
    Fertil Steril 72:975-9. 1999
    ..To evaluate the association between serum P levels on the day of hCG administration and the outcome of intracytoplasmic sperm injection (ICSI)...
  66. ncbi Does early morphology provide additional selection power to blastocyst selection for transfer?
    F Guerif
    Service de Médecine et Biologie de la Reproduction, CHRU de Tours, France
    Reprod Biomed Online 21:510-9. 2010
    ..to evaluate embryo development and fresh single-blastocyst transfer currently seems superior to single-embryo transfer. Would early morphological parameters help to choose the single blastocyst to be transferred, thereby ..
  67. ncbi Impact of frozen-thawed single-blastocyst transfer on maternal and neonatal outcome: an analysis of 277,042 single-embryo transfer cycles from 2008 to 2010 in Japan
    Osamu Ishihara
    Department of Obstetrics and Gynecology, Faculty of Medicine, Saitama Medical University, Saitama, Japan Electronic address
    Fertil Steril 101:128-33. 2014
    ..To evaluate the relationship between frozen-thawed single blastocyst transfer (BT) and maternal and neonatal outcomes of pregnancy...
  68. ncbi Follicular growth and oocyte maturation in GnRH agonist and antagonist protocols for in vitro fertilisation and embryo transfer
    Raffaella Depalo
    Department of Gynecology, Obstetrics and Neonatology, Gynecology and Obstetric Unit A, University of Bari, Piazza Giulio Cesare, Bari, Italy
    Gynecol Endocrinol 25:328-34. 2009
    ..The endpoints were the pattern of follicular growth, the maturity of the oocytes collected, the embryo quality and the pregnancy outcome...
  69. ncbi Embryo loss in cattle between Days 7 and 16 of pregnancy
    D K Berg
    AgResearch, Ruakura Campus, Hamilton, New Zealand
    Theriogenology 73:250-60. 2010
    ..05; winter-spring, P<0.001). Lastly, transuterine migration in cattle, when transferring multiple embryos, commenced at Day 14 (4%) and had occurred in all recipients by Day 16 (38% of embryos found contralaterally)...
  70. ncbi Vaginal micronized progesterone versus intramuscular progesterone for luteal support in women undergoing in vitro fertilization-embryo transfer
    Mohamed F Mitwally
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics, Gynecology and Women s Health, University of Minnesota, Minneapolis, Minnesota, USA
    Fertil Steril 93:554-69. 2010
    ..To study the outcome of IVF-ET in women who used vaginal P (vaginal P(4)) versus those who used P in oil via IM injection (IM-P(4)) for luteal support...
  71. ncbi Crinone vaginal gel is equally effective and better tolerated than intramuscular progesterone for luteal phase support in in vitro fertilization-embryo transfer cycles: a prospective randomized study
    Elena Yanushpolsky
    Department of Obstetrics and Gynecology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115 6114, USA
    Fertil Steril 94:2596-9. 2010
    ..of Crinone vaginal gel and intramuscular progesterone (IMP) for luteal phase support in in vitro fertilization-embryo transfer (IVF-ET) with respect to pregnancy rates and outcomes, and to assess patient satisfaction with both products.
  72. pmc Embryo development of fresh 'versus' vitrified metaphase II oocytes after ICSI: a prospective randomized sibling-oocyte study
    Laura Rienzi
    G E N E R A Centre for Reproductive Medicine, Clinica Valle Giulia, Via De Notaris 2b, Rome, Italy
    Hum Reprod 25:66-73. 2010
    ..Vitrification has been recently proposed as an effective procedure for this purpose...
  73. ncbi Method of oocyte activation affects cloning efficiency in pigs
    Kristin M Whitworth
    Division of Animal Sciences, University of Missouri, Columbia, Missouri 65211, USA
    Mol Reprod Dev 76:490-500. 2009
    ..The beneficial effect of NT2 protocol may be due to the stimulation of proteasomes that infiltrate donor cell nucleus shortly after nuclear transfer...
  74. ncbi Duration of progesterone-in-oil support after in vitro fertilization and embryo transfer: a randomized, controlled trial
    Christine S Goudge
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics, Gynecology and Women s Health, University of Minnesota, Minneapolis, Minnesota 55454, USA
    Fertil Steril 94:946-51. 2010
    To determine the efficacy of a short P-in-oil protocol (11 days) in comparison with a traditional P-in-oil protocol (6 weeks) after IVF and embryo transfer.
  75. ncbi The impact of pronuclei morphology and dynamicity on live birth outcome after time-lapse culture
    A Azzarello
    The Fertility Clinic, Holbaek Regional Hospital, Copenhagen University, Smedelundsgade 60, DK 4300 Holbaek, Denmark
    Hum Reprod 27:2649-57. 2012
    ..Can the pronuclei (PN) morphology and the time of PN breakdown (PNB) predict the potential of embryos to result in live birth?..
  76. ncbi Outcome of intracytoplasmic sperm injection in patients with polycystic ovary syndrome or isolated polycystic ovaries
    Ibrahim Esinler
    Department of Obstetrics and Gynecology, Faculty of Medicine, Hacettepe University, Ankara, Turkey
    Fertil Steril 84:932-7. 2005
    To determine the intracytoplasmic sperm injection (ICSI) and embryo transfer (ET) performance of patients with polycystic ovary syndrome (PCOS) and isolated polycystic ovarian (PCO) morphology.
  77. ncbi Reducing twin pregnancy rates after IVF--elective single embryo transfer (eSET)
    P Milne
    Merrion Fertility Clinic, National Maternity Hospital, Holles Street, Dublin 2
    Ir Med J 103:9-11. 2010
    ..Elective single embryo transfer (eSET) during IVF, rather than the more standard transfer of two embryos (double embryo transfer or DET), has ..
  78. ncbi Changes in serum cortisol and prolactin associated with acupuncture during controlled ovarian hyperstimulation in women undergoing in vitro fertilization-embryo transfer treatment
    Paul C Magarelli
    Reproductive Medicine and Fertility Centers, Colorado Springs, Colorado 80910, USA
    Fertil Steril 92:1870-9. 2009
    ..To determine whether changes in serum cortisol (CORT) and PRL are affected by acupuncture (Ac) in Ac-treated IVF patients...
  79. ncbi Lack of risk of transmission of caprine arthritis-encephalitis virus (CAEV) after an appropriate embryo transfer procedure
    M Z Ali Al Ahmad
    Department of Research into the Health Risks and Biotechnology of Reproduction ENVN DGER, National Veterinary School, Nantes Cedex 03, France
    Theriogenology 69:408-15. 2008
    The aim of this study was to demonstrate that embryo transfer can be used to produce CAEV-free kids from CAEV-infected biological mothers when appropriate procedure is implemented...
  80. ncbi Prospective randomized comparison of human oocyte cryopreservation with slow-rate freezing or vitrification
    Gary D Smith
    Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, Michigan, USA
    Fertil Steril 94:2088-95. 2010
    ..To compare cryopreservation of mature human oocytes with slow-rate freezing and vitrification and determine which is most efficient at establishing a pregnancy...
  81. pmc Single-embryo transfer reduces clinical pregnancy rates and live births in fresh IVF and Intracytoplasmic Sperm Injection (ICSI) cycles: a meta-analysis
    Ricardo L R Baruffi
    Center for Human Reproduction, Sao Paolo, Brazil
    Reprod Biol Endocrinol 7:36. 2009
    ..Single-embryo transfer can minimize twin pregnancies but may also lower live birth rates...
  82. ncbi Are there any normal clones?
    Ian Wilmut
    Department of Gene Function and Development, Roslin Institute, Roslin, Midlothian, UK
    Methods Mol Biol 348:307-18. 2006
    ..Because controlled hypothesis testing of clone fidelity or clone health may not be possible, meticulous documentation of such observational evidence is a valuable contribution to the field...
  83. pmc Use of the natural cycle and vitrification thawed blastocyst transfer results in better in-vitro fertilization outcomes : cycle regimens of vitrification thawed blastocyst transfer
    Eun Mi Chang
    Fertility Center of CHA General Hospital, Department of Obstetrics and Gynecology, College of Medicine, Pochon CHA University, 650 9 Yeoksam, Kangnamgu, Seoul, 135 081, Korea
    J Assist Reprod Genet 28:369-74. 2011
    ..To compare the IVF outcomes of vitrification-thawed blastocyst transfer cycles utilizing different endometrial preparation methods...
  84. ncbi A systematic review and meta-analysis of acupuncture in in vitro fertilisation
    T El-Toukhy
    Assisted Conception Unit, Guy s and St Thomas Hospital, London, UK
    BJOG 115:1203-13. 2008
    ..Numerous randomised studies have reported pregnancy outcome in women who received acupuncture during their in vitro fertilisation (IVF) treatment cycle...
  85. pmc Activation of dormant ovarian follicles to generate mature eggs
    Jing Li
    Department of Obstetrics and Gynecology, Program of Reproductive and Stem Cell Biology, Stanford University School of Medicine, Stanford, CA 94305 5317, USA
    Proc Natl Acad Sci U S A 107:10280-4. 2010
    ..After in vitro fertilization and embryo transfer, healthy progeny with proven fertility were delivered...
  86. ncbi Aseptic vitrification of blastocysts from infertile patients, egg donors and after IVM
    P Vanderzwalmen
    IVF Centers Prof Zech, Bregenz, Austria
    Reprod Biomed Online 19:700-7. 2009
    ..Survival rates before embryo transfer, ongoing pregnancy and implantation rates were as follows: for group 1, 73, 43 and 26%; for group 2, 88, 53 ..
  87. ncbi An investigation into the relationship between the metabolic profile of follicular fluid, oocyte developmental potential, and implantation outcome
    Martina Wallace
    UCD Conway Institute, UCD School of Agriculture, Food Science and Veterinary Medicine, University College Dublin, Belfield, Dublin, Ireland
    Fertil Steril 97:1078-84.e1-8. 2012
    ..To determine whether metabolomic analysis of follicular fluid could prove a useful noninvasive technique for the selection of viable oocytes and embryos...
  88. ncbi Single blastocyst embryo transfer maintains comparable pregnancy rates to double cleavage-stage embryo transfer but results in healthier pregnancy outcomes
    Deirdre L Zander-Fox
    Repromed, Dulwich, South Australia, Australia
    Aust N Z J Obstet Gynaecol 51:406-10. 2011
    ..stage (day 2-3), allows for better selection of the best embryo, maximising pregnancy rates from a single embryo transfer (SET)...
  89. ncbi Determinants of pregnancy rate in the donor oocyte model: a multivariate analysis of 450 frozen-thawed embryo transfers
    Lionel Dessolle
    Service de gynécologie obstétrique et médecine de la reproduction, Hopital Tenon, 75020 Paris, France
    Hum Reprod 24:3082-9. 2009
    ..We used the OD model to determine predictive factors of pregnancy in the recipient after frozen-thawed embryo transfer (FTET) in a specific series where all the embryos were cryopreserved without any prior selection for fresh ..
  90. ncbi Embryo and uterine influences on IVF outcomes: an analysis of a UK multi-centre cohort
    S A Roberts
    Health Sciences Methodology, Manchester Academic Health Science Centre MAHSC, University of Manchester, Manchester, UK
    Hum Reprod 25:2792-802. 2010
    In order to optimize IVF strategies, particularly with the use of single embryo transfer, good predictive models are required...
  91. ncbi Derivation of a human blastocyst after heterologous nuclear transfer to donated oocytes
    Miodrag Stojkovic
    Centre for Stem Cell Biology and Developmental Genetics, University of Newcastle, UK
    Reprod Biomed Online 11:226-31. 2005
    ..However, if the promise of this new science is to achieve its potential in the foreseeable future, it will be necessary to identify new sources of oocytes that can be used immediately after retrieval...
  92. ncbi Prediction of in-vitro developmental competence of early cleavage-stage mouse embryos with compact time-lapse equipment
    Csaba Pribenszky
    Department of Animal Breeding and Genetics, Faculty of Veterinary Science, Szent Istvan University, Istvan u 2, Budapest 1078, Hungary
    Reprod Biomed Online 20:371-9. 2010
    ....
  93. ncbi GnRH-agonist induced depressive and anxiety symptoms during in vitro fertilization-embryo transfer cycles
    Miki Bloch
    Department of Psychiatry, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    Fertil Steril 95:307-9. 2011
    ....
  94. ncbi The non-independence of treatment outcomes from repeat IVF cycles: estimates and consequences
    Stephen A Roberts
    Health Sciences Methodology, Manchester Academic Health Science Centre MAHSC, University of Manchester, Manchester M13 9WL, UK
    Hum Reprod 27:436-43. 2012
    ..However, there are few studies that have attempted to estimate the magnitude of these effects or their clinical consequences...
  95. ncbi Morphological characterization of pre- and peri-implantation in vitro cultured, somatic cell nuclear transfer and in vivo derived ovine embryos
    P Tveden-Nyborg
    Department of Animal and Veterinary Basic Sciences, Royal Veterinary and Agricultural University, Groennegaardsvej 7, DK 1870 Frederiksberg C, Denmark
    Reproduction 130:681-94. 2005
    ..We conclude that IVC and particularly SCNT procedures cause a retardation of embryo development and cell differentiation at days 7-19 of gestation...
  96. ncbi Survivin gene expression in granulosa cells from infertile patients undergoing in vitro fertilization-embryo transfer
    Kuniko Fujino
    Department of Obstetrics and Gynecology, Osaka Medical College, 2 7 Daigakumachi, Takatsuki, Osaka 569 8686, Japan
    Fertil Steril 89:60-5. 2008
    ..To evaluate survivin gene expression in granulosa cells from infertile patients and examine the relationship between survivin gene expression and infertile clinical background...
  97. ncbi Reducing the incidence of twins from IVF treatments: predictive modelling from a retrospective cohort
    Stephen A Roberts
    Health Sciences Methodology, University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9WL, UK
    Hum Reprod 26:569-75. 2011
    ..Increased use of elective single embryo transfer (eSET) can reduce this twin rate...
  98. ncbi Acupuncture on the day of embryo transfer significantly improves the reproductive outcome in infertile women: a prospective, randomized trial
    Lars G Westergaard
    Fertility Clinic Trianglen, Hellerup, Denmark
    Fertil Steril 85:1341-6. 2006
    ..One group of patients received acupuncture on the day of ET, another group on ET day and again 2 days later (i.e., closer to implantation day), and both groups were compared with a control group that did not receive acupuncture...
  99. ncbi Acquired and inherited thrombophilia: implication in recurrent IVF and embryo transfer failure
    Hussein S Qublan
    Department of Obstetrics and Gynecology, Royal Medical Services, Jordan Armed Forces, Irbid, Jordan
    Hum Reprod 21:2694-8. 2006
    The objective of this study was to determine the incidence of undiagnosed thrombophilic factors and its relation to IVF and embryo transfer failure in women who have had three or more previous IVF-embryo transfer cycles.
  100. ncbi Identification of the high-risk patient for ovarian hyperstimulation syndrome
    Evangelos G Papanikolaou
    Assisted Reproduction Unit, 1st OB GYN Department, Aristotle University of Thessaloniki, Thessaloniki, Greece
    Semin Reprod Med 28:458-62. 2010
    ..Until reliable genetic tests are available, and considering that the occurrence of pregnancy is unpredictable, the use of prognostic factors will be mainly indicative of risk rather than preventive of OHSS...
  101. ncbi Fetal microchimerism in normal and embryo transfer bovine pregnancies
    L Turin
    Dipartimento di Patologia Animale, Igiene e Sanita Pubblica Veterinaria, Universita di Milano, Via Celoria 10, 20133, Milano, Italy
    Vet Res Commun 31:205-7. 2007

Research Grants63

  1. Supporting Human ART Through Basic Science
    Barry Bavister; Fiscal Year: 2004
    ..for a 1-day symposium to be held in conjunction with the January 2004 Annual Meeting of the International Embryo Transfer Society in Portland, OR...
  2. Validation of Novel Infertility Biomarker
    PETER SUTOVSKY SUTOVSKY; Fiscal Year: 2012
    ..embryo cleavage rates, incidence of spontaneous abortion following a successful assisted fertilization and embryo transfer, and the incidence of multiple pregnancies in couples treated by ART...
  3. Development of Superactive Analogs of FSH for Human Infertility
    BRUCE DALE WEINTRAUB; Fiscal Year: 2013
    ..the classic ovarian weight response as well as those of oocytes, blastocysts and newborn pups resulting from embryo transfer. In all these rodent models 4401 greatly outperformed all currently available recombinant FSH preparations ..
  4. Non-invasive method to evaluate the quality of human oocytes and embryos
    XINGQI JOHN ZHANG; Fiscal Year: 2013
    ..The result of the cGEP assay---a cGEP score--- can be used to predict embryo quality and ultimately the embryo transfer (ET) results...
  5. Midcareer Investigator Award in Patient Oriented Research
    Kurt T Barnhart; Fiscal Year: 2013
    ..SA#1 will use the national SART database to test if a fresh embryo transfer is associated with increased adverse outcome compared to frozen embryo transfer...
  6. COOPERATIVE MULTICENTER REPRODUCTIVE MEDICINE NETWORK
    Christos Coutifaris; Fiscal Year: 2013
    ..double blastocyst transfer. In addition, we propose to include subsequent frozen/thawed embryo transfer cycles in order to determine cumulative delivery rates...
  7. ACE2 Deficiency: A new model of maternal and fetal growth restriction.
    Liliya M Yamaleyeva; Fiscal Year: 2013
    ..Specific Aim 3 will determine whether maternal or fetal ACE2 KO is necessary for the fetal weight restriction using embryo transfer.
  8. National Gnotobiotic Rodent Resource Center
    Ryan B Sartor; Fiscal Year: 2013
    ..UNC Mutant Mouse Regional Resource Center (MMRRC), 2) the experience of the applicant team, 3) innovation in embryo transfer and cryopreservation, 4) The option for onsite tissue collection by external investigators, 5) highly trained ..
  9. Elucidating adiposity in a mouse model of prenatal undernutrition
    ELVIRA MARIE ISGANAITIS; Fiscal Year: 2011
    ..F1 intrauterine environment in the inter- generational transmission of obesity and Pref1 expression by using embryo transfer techniques...
  10. High Throughput Cryopreservation of In Vivo-Derived Swine Embryos
    Randall S Prather; Fiscal Year: 2010
    ..Unfortunately with current procedures this results in a break in the zona pellucida. The International Embryo Transfer Society guidelines state that the zona pellucida cannot be compromised if the health status is to be ..
  11. Use of OET to assess mouse preimplantation quality for uterine transfer
    MAURICE MARCEL GARCIA; Fiscal Year: 2013
    ..with the support necessary to accomplish the following goals: (1) to become expert in the use of the mouse embryo transfer model and study of preimplantation embryo quality;(2) to further develop a promising technology, OET (..
  12. A non-surgical embryo transfer device for producing gene modified rats
    SHANNON C BASS; Fiscal Year: 2010
    ..To overcome these problems we propose to develop a Non-Surgical Embryo Transfer (NSET) device that can be used for the non-surgical transfer of embryos into female rats...
  13. Pathways of Mother to Child Transmission of Metabolic Risk
    ELVIRA MARIE ISGANAITIS; Fiscal Year: 2013
    ..F1 intrauterine environment in the inter- generational transmission of obesity and Pref1 expression by using embryo transfer techniques...
  14. Embryotropic actions of follistatin: mechanisms and translational relevance
    George W Smith; Fiscal Year: 2013
    ..embryotropic actions and impact of follistatin treatment during embryo culture on pregnancy rates following embryo transfer limit understanding of the functional significance of follistatin to early embryogenesis and the ..
  15. Embryo Transfer for the Study of Transgenerational Modifications in Morphine Sens
    Elizabeth M Byrnes; Fiscal Year: 2013
    ..The purpose of this proposal is to develop, refine, and implement non-surgical embryo transfer in females exposed to morphine during adolescent development...
  16. A non-surgical embryo transfer (NSET) device for producing gene-modified mice
    Brett T Spear; Fiscal Year: 2012
    ..This proposal investigates and expands upon the utility of this embryo transfer device by establishing the optimal ages and mouse strains for embryo transfer (Aim 1), determining whether ..
  17. Defects in Mitochondria Impacting Primate Oocyte Quality
    DAVID RANDALL ARMANT; Fiscal Year: 2010
    ..a non-invasive marker or predictor of oocyte competence so that only the most viable embryos are selected for embryo transfer. This information could then be evaluated in other clinical studies for application to human oocytes and ..
  18. Core Rederivation and Barrier Renovation
    James W Tracy; Fiscal Year: 2010
    ..A centralized core embryo cryopreservation and embryo transfer laboratory will be constructed and outfitted...
  19. REGULATION OF MHC GENES IN TROPHOBLAST
    DOUGLAS ANTCZAK; Fiscal Year: 1999
    ..the capacity to produce inter-species mule pregnancies and fully xenogeneic donkey-in-horse pregnancies by embryo transfer. These provide unique models of pregnancy and pregnancy failure for the study of immunological factors that ..
  20. YOUNG FROM STORED AND IMPAIRED MOUSE SPERM
    John Biggers; Fiscal Year: 2001
    ..artificial insemination, in vitro fertilization, intracellular sperm injection, embryo culture and embryo transfer. The overall efficiency of any particular path in this algorithm is defined as the number of pups born x 100/..
  21. ABNORMALITIES IN CALVES FROM EMBRYO TRANSFER
    George Seidel; Fiscal Year: 1980
    ..before its consequences are fully understood will increase over the next decade as in vitro fertilization and embryo transfer are also applied to the treatment of human infertility...
  22. PAF AND PRE-IMPLANTATION/IMPLANTATION PHENOMENA
    Michael Harper; Fiscal Year: 1991
    ..5) examine the relevance of embryoderived PAF for the ovum transport and implantation process by means of embryo transfer techniques following treatment of the embryos with synthetic PAF and PAF antagonists, 6) localize PAF binding ..
  23. STRATEGIES FOR PRIMATE TRANSGENESIS
    Thaddeus Golos; Fiscal Year: 2003
    ..Specific Aim 2 is to establish nonsurgical embryo transfer methods for the rhesus monkey...
  24. EMBRYO TECHNOLOGIES FOR PROPAGATION OF RHESUS MONKEYS
    Barry Bavister; Fiscal Year: 2006
    ..However, the current state of basic ART procedures in NHPs, such as embryo transfer and production of identical twins, is poor. Few studies have been devoted to improving these procedures...
  25. METABOLIC TESTS OF VIABILITY IN PREIMPLANTATION EMBRYOS
    James Butler; Fiscal Year: 1992
    ..b>Embryo transfer experiments will then be carried out to determine the possible relationship between substrate uptake in vitro ..
  26. Preservation of ejaculated mouse spermatozoa
    MONIKA WARD; Fiscal Year: 2006
    ..effects of these methods on sperm DNA integrity by analysis of patemal chromosomes in the zygotes and perform embryo transfer and produce live offspring...
  27. ARTIFICIAL INSEMINATION AND EMBRYO TRANSFER
    DUAN KRAEMER; Fiscal Year: 1990
    ..cryopreservation and artificial insemination; superovulation; embryo collection and intra- and inter-species embryo transfer. Semen will be collected by electroejaculation of anesthetized males and frozen in an extender which has ..
  28. DEVELOPMENTAL POTENTIAL OF MARMOSET ES CELLS
    James Thomson; Fiscal Year: 2000
    ..and a prostaglandin sensitive corpus luteum that allows synchronization of reproductive cycles and efficient embryo transfer. In the proposal, we will: 1...
  29. MODELS OF HYPOXIC PULMONARY HYPERTENSION
    Archibald Alexander; Fiscal Year: 1980
    ..During the coming year we will continue: (a) to examine by embryo transfer and progeny testing whether the traits for susceptibility and resistance to hypoxic pulmonary hypertension in ..
  30. PROSTAGLANDIN SIGNALING IN FEMALE REPRODUCTION
    John Reese; Fiscal Year: 2005
    ..4) fetal PGs rescue parturition failure in COX-1 -/- recipient mice carrying wild-type embryos resulting from embryo transfer. Collectively, these results suggest that multiple aspects of parturition converge on the PG signaling ..
  31. CADMIUM EFFECTS ON GENE EXPRESSION AND EMBRYOGENESIS
    Glen Andrews; Fiscal Year: 1990
    ..Preimplantation embryos will also be exposed to metals in vitro followed by embryo transfer and subsequent analysis of development.
  32. A non-surgical embryo transfer (NSET) device for producing gene-modified mice
    Shannon Bass; Fiscal Year: 2009
    ..To overcome these problems, we have developed a Non-Surgical Embryo Transfer (NSET) device that can be used for the non-surgical transfer of embryos into female mice...
  33. THE MAJOR ANGIOGENIC FACTORS IN PLACENTAL ANGIOGENESIS
    Lawrence Reynolds; Fiscal Year: 2004
    ..For this study, we will use a model that we have recently established for reciprocal embryo transfer between a highly prolific and a less prolific breed of sheep...
  34. Development of Superactive Analogs of Follice Stimulating Hormone (FSH)
    Bruce Weintraub; Fiscal Year: 2007
    ..Pohley assay, various assays of in vitro fertilization and embryo development and, in selected cases, embryo transfer to surrogate females, assessment of pregnancy rates and the quantity and quality of newborn pups...
  35. FUNCTION OF UTERINE CALCITONIN DURING IMPLANTATION
    INDRANI BAGCHI; Fiscal Year: 2002
    ..CT deficiency on (a) uterine receptivity and (b) the ability of the embryo to implant will be examined by embryo transfer experiments. 2...
  36. KIT FOR CONSTRUCTING ES CELL/BLASTOCYST CHIMERAS
    John Biggers; Fiscal Year: 1999
    ..designed so that it can be used by investigators with only limited experience with mouse embryo culture and embryo transfer. Costs of making knock-out mice will be significantly reduced by eliminating the need for local animal ..
  37. Maternal Liver Disease and Fatty Acid Oxidation Defects
    Jamal Ibdah; Fiscal Year: 2005
    ..2) To employ preimplantation genotyping and embryo transfer to independently study the effects of fetal and maternal genotypes on development of maternal liver disease ..
  38. Rederivation and Internal Quarantine Suite (RIQS)
    JEFFREY GOODWIN; Fiscal Year: 2009
    ..specialized space to isolate and rederive diseased or suspect animals to produce disease-free offspring via embryo transfer to clean foster mothers...
  39. Genomics approaches in comparative medicine
    Jorge Piedrahita; Fiscal Year: 2003
    ..workshop will be held as a satellite meeting immediately prior to the annual meeting of the International Embryo Transfer Society...
  40. From embryo to adult: mechanisms of fetal programming
    Tom Fleming; Fiscal Year: 2006
    ..We have also developed an in vitro culture and embryo transfer model, which replicates the programming effects of the in vivo LPD diet model, to support investigation of ..
  41. PREIMPLANTATION IDENTIFICATION OF TRANSGENIC EMBRYOS
    KATHERINE GORDON; Fiscal Year: 1990
    ..This method of genomic analysis will maintain embryo viability and is intended to restrict embryo transfer to the small subset of microinjected embryos bearing integrated transgenes...
  42. REGRESSION METHODS FOR INFERTILITY DATA
    Joseph Hogan; Fiscal Year: 1999
    ..in studies of outcome in infertility, particularly those related to treatments by in vitro fertilization and embryo transfer (IVF-ET)...
  43. MICROBIAL PATHOGENS IN RODENT GAMETE AND EMBRYO BANKING
    Lela Riley; Fiscal Year: 2005
    ..Methods to efficiently freeze mouse embryos and regenerate strains stocks from frozen stocks via embryo transfer are well established for the mouse, but little work has been done in developing efficient rat embryo ..
  44. ANTI-VIRAL TREATMENT OF DEVELOPING BOVINE EMBRYOS
    Maurice Givens; Fiscal Year: 2002
    ....
  45. MHC-Defined and Identical Twin Monkeys for Research
    Joseph Kemnitz; Fiscal Year: 2005
    ..will use blastomere biopsy and PCR in conjunction with in vitro fertilization (IVF) and selective embryo transfer, to produce approximately 150 MHC-defined offspring over the five year study period...
  46. Role of integrins and activin in granulosa cell growth
    Kutluk Oktay; Fiscal Year: 2007
    ..Cell proliferation and survival will be determined before and after transfection with the dominant-negative mutants. ..
  47. Characterizing Mammalian Embryonic polyA Binding Protein
    Emre Seli; Fiscal Year: 2008
    ....
  48. PROTEIN PHOSPHATASES AND OOCYTE MEIOSIS
    Gary Smith; Fiscal Year: 2002
    ..These studies will provide novel information concerning control of oocyte maturation and spindle formation that may subsequently influence the developmental competency of resulting embryos. ..
  49. Full karyotype single cell interphase analysis
    Santiago Munne; Fiscal Year: 2005
    ..In phase-I we propose to develop two of the three sets of probes, and to test that these probes will work with 90% efficiency after three rounds of hybridization in single polar bodies. ..
  50. Insulin and Oocyte Chromatin Segregation
    Gary Smith; Fiscal Year: 2009
    ..abstract_text> ..
  51. Endogenous Relaxin Regulates Vascular Function in Nonpregnant Females and Males
    KIRK CONRA; Fiscal Year: 2009
    ..Thus, the influence of endogenous Rlx on vascular function is likely to be a general phenomenon, and not one limited exclusively to pregnancy. ..
  52. How do oocytes & embryos cope with adverse environments?
    Jeremy Thompson; Fiscal Year: 2007
    ..This knowledge will also assist health professionals develop strategies to reduce the risk of adult onset diseases caused by perturbed early development. ..
  53. Novel method to produce transgenic rabbits
    Fuliang Du; Fiscal Year: 2004
    ....
  54. MECHANISMS OF VASODILATION IN PREGNANCY
    Kirk Conrad; Fiscal Year: 2001
    ..Hypothesis 3. Relaxin also contributes to NO-dependent renal vasodilation and hyperfiltration in gravid rats. Hypothesis 4. Relaxin contributes to renal vasodilation, hyperfiltration, and osmoregulatory changes in gravid women. ..
  55. MARKER ASSISTED SELECTION OF BOVINE BLASTOCYSTS
    HANS KUBISCH; Fiscal Year: 2002
    ....
  56. Oxidative Stress and Oocyte Development
    CATHERINE COMBELLES; Fiscal Year: 2007
    ..These findings will enhance our ability to detect and produce oocytes of optimal quality, thereby providing critical foundations for the improvement of female reproductive health. [unreadable] [unreadable] [unreadable]..
  57. GENOME RESOURCE BANKING OF RARE FELID POPULATIONS
    William Swanson; Fiscal Year: 2006
    ..this approach ultimately depends upon applying effective methods for embryo production, cryopreservation, and embryo transfer (ET)...
  58. ENHANCERS AND LIVER-SPECIFIC TRANSCRIPTION
    Brett Spear; Fiscal Year: 2001
    ..In addition, the information derived from these studies may improve strategies to express foreign genes within the liver, a goal of many gene therapy trials. ..
  59. NATIONAL GENE VECTOR LABORATORY AT INDIANA UNIVERSITY
    Kenneth Cornetta; Fiscal Year: 2007
    ..abstract_text> ..