dose fractionation

Summary

Summary: Administration of the total dose of radiation (RADIATION DOSAGE) in parts, at timed intervals.

Top Publications

  1. ncbi Monotherapeutic high-dose-rate brachytherapy for prostate cancer: five-year results of an extreme hypofractionation regimen with 54 Gy in nine fractions
    Yasuo Yoshioka
    Department of Radiation Oncology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Int J Radiat Oncol Biol Phys 80:469-75. 2011
  2. ncbi Long-term outcomes from a prospective trial of stereotactic body radiotherapy for low-risk prostate cancer
    Christopher R King
    Departments of Radiation Oncology, University of California Los Angeles School of Medicine, Los Angeles, CA 90095, USA
    Int J Radiat Oncol Biol Phys 82:877-82. 2012
  3. ncbi The radiobiology of prostate cancer including new aspects of fractionated radiotherapy
    Jack F Fowler
    Emeritus of Medical School of Wisconsin University, Department of Human Oncology, University of Wisconsin Madison, USA
    Acta Oncol 44:265-76. 2005
  4. ncbi Multi-institutional phase I/II trial of stereotactic body radiation therapy for lung metastases
    Kyle E Rusthoven
    University of Colorado Denver, Department of Radiation Oncology and Medical Oncology, Aurora, CO 80045, USA
    J Clin Oncol 27:1579-84. 2009
  5. ncbi Hypofractionated stereotactic radiotherapy (HypoFXSRT) for stage I non-small cell lung cancer: updated results of 257 patients in a Japanese multi-institutional study
    Hiroshi Onishi
    Department of Radiology, School of Medicine, Yamanashi University, Shimokato, Chuo City, Yamanashi, Japan
    J Thorac Oncol 2:S94-100. 2007
  6. ncbi Hypofractionated intensity-modulated radiotherapy (70 Gy at 2.5 Gy per fraction) for localized prostate cancer: Cleveland Clinic experience
    Patrick A Kupelian
    Department of Radiation Oncology, M D Anderson Cancer Center Orlando, Orlando, FL 32806, USA
    Int J Radiat Oncol Biol Phys 68:1424-30. 2007
  7. ncbi Long-term results of hypofractionated radiation therapy for breast cancer
    Timothy J Whelan
    McMaster University and Juravinski Cancer Centre, Hamilton, ON, Canada
    N Engl J Med 362:513-20. 2010
  8. ncbi Multi-institutional phase I/II trial of stereotactic body radiation therapy for liver metastases
    Kyle E Rusthoven
    University of Colorado Denver, Department of Radiation Oncology, Pathology, and Medical Oncology, Aurora, CO 80045, USA
    J Clin Oncol 27:1572-8. 2009
  9. ncbi Acute and late toxicity in a randomized trial of conventional versus hypofractionated three-dimensional conformal radiotherapy for prostate cancer
    Giorgio Arcangeli
    Department of Radiation Oncology, Regina Elena National Cancer Institute, Rome, Italy
    Int J Radiat Oncol Biol Phys 79:1013-21. 2011
  10. pmc Intrafractional motion of the prostate during hypofractionated radiotherapy
    Yaoqin Xie
    Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305 5847, USA
    Int J Radiat Oncol Biol Phys 72:236-46. 2008

Detail Information

Publications308 found, 100 shown here

  1. ncbi Monotherapeutic high-dose-rate brachytherapy for prostate cancer: five-year results of an extreme hypofractionation regimen with 54 Gy in nine fractions
    Yasuo Yoshioka
    Department of Radiation Oncology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Int J Radiat Oncol Biol Phys 80:469-75. 2011
    ..To evaluate an extreme hypofractionation regimen with 54 Gy in nine fractions provided by high-dose-rate (HDR) brachytherapy as monotherapy for prostate cancer by reporting 5-year clinical results...
  2. ncbi Long-term outcomes from a prospective trial of stereotactic body radiotherapy for low-risk prostate cancer
    Christopher R King
    Departments of Radiation Oncology, University of California Los Angeles School of Medicine, Los Angeles, CA 90095, USA
    Int J Radiat Oncol Biol Phys 82:877-82. 2012
    ..The results of a prospective trial of stereotactic body radiotherapy (SBRT) for prostate cancer with long-term patient-reported toxicity and tumor control rates are presented...
  3. ncbi The radiobiology of prostate cancer including new aspects of fractionated radiotherapy
    Jack F Fowler
    Emeritus of Medical School of Wisconsin University, Department of Human Oncology, University of Wisconsin Madison, USA
    Acta Oncol 44:265-76. 2005
    ..Monotherapy by brachytherapy for low-risk cancer prostate using two to four fractions in a few days can give even higher biological effects on the tumors...
  4. ncbi Multi-institutional phase I/II trial of stereotactic body radiation therapy for lung metastases
    Kyle E Rusthoven
    University of Colorado Denver, Department of Radiation Oncology and Medical Oncology, Aurora, CO 80045, USA
    J Clin Oncol 27:1579-84. 2009
    ..To evaluate the efficacy and tolerability of high-dose stereotactic body radiation therapy (SBRT) for the treatment of patients with one to three lung metastases...
  5. ncbi Hypofractionated stereotactic radiotherapy (HypoFXSRT) for stage I non-small cell lung cancer: updated results of 257 patients in a Japanese multi-institutional study
    Hiroshi Onishi
    Department of Radiology, School of Medicine, Yamanashi University, Shimokato, Chuo City, Yamanashi, Japan
    J Thorac Oncol 2:S94-100. 2007
    ..We retrospectively analyzed the treatment outcome of HypoFXSRT for stage I non-small cell lung cancer (NSCLC) treated in a Japanese multi-institutional study...
  6. ncbi Hypofractionated intensity-modulated radiotherapy (70 Gy at 2.5 Gy per fraction) for localized prostate cancer: Cleveland Clinic experience
    Patrick A Kupelian
    Department of Radiation Oncology, M D Anderson Cancer Center Orlando, Orlando, FL 32806, USA
    Int J Radiat Oncol Biol Phys 68:1424-30. 2007
    ..To study the outcomes in patients treated for localized prostate cancer with 70 Gy delivered at 2.5-Gy/fraction within 5 weeks...
  7. ncbi Long-term results of hypofractionated radiation therapy for breast cancer
    Timothy J Whelan
    McMaster University and Juravinski Cancer Centre, Hamilton, ON, Canada
    N Engl J Med 362:513-20. 2010
    ..The optimal fractionation schedule for whole-breast irradiation after breast-conserving surgery is unknown...
  8. ncbi Multi-institutional phase I/II trial of stereotactic body radiation therapy for liver metastases
    Kyle E Rusthoven
    University of Colorado Denver, Department of Radiation Oncology, Pathology, and Medical Oncology, Aurora, CO 80045, USA
    J Clin Oncol 27:1572-8. 2009
    ..To evaluate the efficacy and tolerability of high-dose stereotactic body radiation therapy (SBRT) for the treatment of patients with one to three hepatic metastases...
  9. ncbi Acute and late toxicity in a randomized trial of conventional versus hypofractionated three-dimensional conformal radiotherapy for prostate cancer
    Giorgio Arcangeli
    Department of Radiation Oncology, Regina Elena National Cancer Institute, Rome, Italy
    Int J Radiat Oncol Biol Phys 79:1013-21. 2011
    ..To compare the toxicity between hypofractionation vs. conventional fractionation schedules in patients with high-risk prostate cancer...
  10. pmc Intrafractional motion of the prostate during hypofractionated radiotherapy
    Yaoqin Xie
    Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305 5847, USA
    Int J Radiat Oncol Biol Phys 72:236-46. 2008
    ..To report the characteristics of prostate motion as tracked by the stereoscopic X-ray images of the implanted fiducials during hypofractionated radiotherapy with CyberKnife...
  11. ncbi Planning target margin calculations for prostate radiotherapy based on intrafraction and interfraction motion using four localization methods
    Chris Beltran
    Department of Radiation Oncology, Mayo Clinic College of Medicine, Rochester, MN, USA
    Int J Radiat Oncol Biol Phys 70:289-95. 2008
    ....
  12. ncbi Dose-fractionation sensitivity of prostate cancer deduced from radiotherapy outcomes of 5,969 patients in seven international institutional datasets: α/β = 1.4 (0.9-2.2) Gy
    Raymond Miralbell
    University Hospital, Geneva, Switzerland
    Int J Radiat Oncol Biol Phys 82:e17-24. 2012
    There are reports of a high sensitivity of prostate cancer to radiotherapy dose fractionation, and this has prompted several trials of hypofractionation schedules...
  13. ncbi Radiotherapy plus cetuximab for locoregionally advanced head and neck cancer: 5-year survival data from a phase 3 randomised trial, and relation between cetuximab-induced rash and survival
    James A Bonner
    University of Alabama, Birmingham, AL, USA
    Lancet Oncol 11:21-8. 2010
    ..Here we report the 5-year survival data, and investigate the relation between cetuximab-induced rash and survival...
  14. ncbi Virtual HDR CyberKnife treatment for localized prostatic carcinoma: dosimetry comparison with HDR brachytherapy and preliminary clinical observations
    Donald B Fuller
    Radiosurgery Medical Group, Inc, San Diego CyberKnife Center, San Diego, CA 92123, USA
    Int J Radiat Oncol Biol Phys 70:1588-97. 2008
    ..We also report early clinical observations of CK SBRT treatment...
  15. ncbi High-dose radiation improved local tumor control and overall survival in patients with inoperable/unresectable non-small-cell lung cancer: long-term results of a radiation dose escalation study
    Feng Ming Kong
    Department of Radiation Oncology, University of Michigan, 1500 E Medical Center Drive, Ann Arbor, MI 48109, USA
    Int J Radiat Oncol Biol Phys 63:324-33. 2005
    ..To determine whether high-dose radiation leads to improved outcomes in patients with non-small-cell lung cancer (NSCLC)...
  16. pmc A phase I/II radiation dose escalation study with concurrent chemotherapy for patients with inoperable stages I to III non-small-cell lung cancer: phase I results of RTOG 0117
    Jeffrey D Bradley
    Washington University School of Medicine, St Louis, Missouri, USA
    Int J Radiat Oncol Biol Phys 77:367-72. 2010
    ....
  17. ncbi High-dose-rate monotherapy: safe and effective brachytherapy for patients with localized prostate cancer
    D Jeffrey Demanes
    California Endocurietherapy at UCLA, Department of Radiation Oncology, David Geffen School of Medicine of the University of California at Los Angeles, Los Angeles, CA 90095, USA
    Int J Radiat Oncol Biol Phys 81:1286-92. 2011
    ..We report the disease control and toxicity of HDR monotherapy from California Endocurietherapy (CET) and William Beaumont Hospital (WBH) in low- and intermediate-risk prostate cancer patients...
  18. ncbi Sexual function after stereotactic body radiotherapy for prostate cancer: results of a prospective clinical trial
    Ellen A Wiegner
    Department of Radiation Oncology, Stanford University School of Medicine, CA, USA
    Int J Radiat Oncol Biol Phys 78:442-8. 2010
    ..To study the sexual quality of life for prostate cancer patients after stereotactic body radiotherapy (SBRT)...
  19. ncbi Hypofractionated stereotactic radiotherapy alone without whole-brain irradiation for patients with solitary and oligo brain metastasis using noninvasive fixation of the skull
    Hidefumi Aoyama
    Department of Radiology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Int J Radiat Oncol Biol Phys 56:793-800. 2003
    ....
  20. ncbi Low-dose hypersensitivity: current status and possible mechanisms
    M C Joiner
    Gray Laboratory Cancer Research Trust, Mount Vernon Hospital, Northwood, Middlesex, UK
    Int J Radiat Oncol Biol Phys 49:379-89. 2001
    ..In this paper, we propose possible mechanisms to explain this phenomenon based on our data accumulated over the last decade and a review of the literature...
  21. ncbi Direct evidence that prostate tumors show high sensitivity to fractionation (low alpha/beta ratio), similar to late-responding normal tissue
    David J Brenner
    Center for Radiological Research, Department of Radiation Oncology, Columbia University, New York, NY 10032, USA
    Int J Radiat Oncol Biol Phys 52:6-13. 2002
    ..A direct approach to the question of whether prostate tumors have an atypically high sensitivity to fractionation (low alpha/beta ratio), more typical of the surrounding late-responding normal tissue...
  22. ncbi Is alpha/beta for prostate tumors really low?
    J Fowler
    Department of Human Oncology, University of Wisconsin Madison, Madison, WI 53792, USA
    Int J Radiat Oncol Biol Phys 50:1021-31. 2001
    ..The implications for possibly treating prostatic cancer using fewer and larger fractions are important. In this paper we review updated clinical data and present somewhat different calculations to estimate alpha/beta...
  23. pmc Sequential vs. concurrent chemoradiation for stage III non-small cell lung cancer: randomized phase III trial RTOG 9410
    Walter J Curran
    Department of Radiation Oncology and Winship Cancer Institute, Emory University, 1365C Clifton Rd, NE, Ste C4104, Atlanta, GA 30322, USA
    J Natl Cancer Inst 103:1452-60. 2011
    ..However, it is not known whether sequential or concurrent delivery of these therapies is the optimal combination strategy...
  24. pmc The linear-quadratic model is an appropriate methodology for determining isoeffective doses at large doses per fraction
    David J Brenner
    Center for Radiological Research, Columbia University Medical Center, 630 West 168th Street, New York, NY 10032, USA
    Semin Radiat Oncol 18:234-9. 2008
    ..To date, there is no evidence of problems when the LQ model has been applied in the clinic...
  25. ncbi High-dose-rate brachytherapy alone for localized prostate cancer in patients at moderate or high risk of biochemical recurrence
    Peter Hoskin
    Cancer Centre, Mount Vernon Hospital, Northwood, Middlesex, UK
    Int J Radiat Oncol Biol Phys 82:1376-84. 2012
    ..To evaluate genitourinary (GU) and gastrointestinal (GI) morbidity and biochemical control of disease in patients with localized prostate adenocarcinoma treated with escalating doses per fraction of high-dose rate brachytherapy alone...
  26. ncbi Five compared with six fractions per week of conventional radiotherapy of squamous-cell carcinoma of head and neck: DAHANCA 6 and 7 randomised controlled trial
    Jens Overgaard
    Department of Experimental Clinical Oncology, Aarhus University Hospital, Nørrebrogade 44, Building 5, DK 8000 C, Aarhus, Denmark
    Lancet 362:933-40. 2003
    ..We aimed to find out whether shortening of treatment time by use of six instead of five radiotherapy fractions per week improves the tumour response in squamous-cell carcinoma...
  27. ncbi Stereotactic body radiotherapy for primary hepatocellular carcinoma
    David L Andolino
    Department of Radiation Oncology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Int J Radiat Oncol Biol Phys 81:e447-53. 2011
    ..To evaluate the safety and efficacy of stereotactic body radiotherapy (SBRT) for the treatment of primary hepatocellular carcinoma (HCC)...
  28. ncbi Stereotactic body radiation therapy in recurrent hepatocellular carcinoma
    Wen Yen Huang
    Department of Radiation Oncology, Tri Service General Hospital, National Defense Medical Center, Taipei, Taiwan, ROC
    Int J Radiat Oncol Biol Phys 84:355-61. 2012
    ..To examine the safety and efficacy of Cyberknife stereotactic body radiation therapy (SBRT) and its effect on survival in patients of recurrent hepatocellular carcinoma (HCC)...
  29. ncbi Phase I study of individualized stereotactic body radiotherapy of liver metastases
    Mark T Lee
    Radiation Medicine Program, Department of Biostatistics and Medical Oncology, Princess Margaret Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada
    J Clin Oncol 27:1585-91. 2009
    ..To report on the outcomes of a phase I study of stereotactic body radiotherapy (SBRT) for treatment of liver metastases...
  30. pmc 21 years of biologically effective dose
    J F Fowler
    University of Wisconsin Medical School, Madison, WI 53792, USA
    Br J Radiol 83:554-68. 2010
    ..BED is now used for dose escalation studies, radiochemotherapy, brachytherapy, high-LET particle beams, radionuclide-targeted therapy, and for quantifying any treatments using ionising radiation...
  31. ncbi Tolerance of organs at risk in small-volume, hypofractionated, image-guided radiotherapy for primary and metastatic lung cancers
    Rikiya Onimaru
    Department of Radiology, Hokkaido University School of Medicine, Sapporo, Japan
    Int J Radiat Oncol Biol Phys 56:126-35. 2003
    ..To determine the organ at risk and the maximum tolerated dose (MTD) of radiation that could be delivered to lung cancer using small-volume, image-guided radiotherapy (IGRT) using hypofractionated, coplanar, and noncoplanar multiple fields...
  32. ncbi Stereotactic Body Radiation Therapy (SBRT) for lung metastases
    Paul Okunieff
    Department of Radiation Oncology, University of Rochester Medical Center, Rochester, NY, USA
    Acta Oncol 45:808-17. 2006
    ..Median survival time and progression-free survival both appear better than that achieved with standard care alone. Long-term progression-free survival can be seen in a subset of patients when all tumors are targeted...
  33. ncbi Radiobiological evaluation of the radiation dose as used in high-precision radiotherapy: effect of prolonged delivery time and applicability of the linear-quadratic model
    Yuta Shibamoto
    Department of Radiology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    J Radiat Res 53:1-9. 2012
    ..For normal tissue responses, improved models have been proposed, but, for in vivo tumor responses, the currently available models are not satisfactory, and better ones should be proposed in future studies...
  34. pmc The UK Standardisation of Breast Radiotherapy (START) Trial B of radiotherapy hypofractionation for treatment of early breast cancer: a randomised trial
    S M Bentzen
    Lancet 371:1098-107. 2008
    ..0 Gy in terms of local-regional tumour control, normal tissue responses, quality of life, and economic consequences in women prescribed post-operative radiotherapy...
  35. ncbi Preliminary results of radiation dose escalation for locally advanced nasopharyngeal carcinoma
    Dora L W Kwong
    Department of Clinical Oncology, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong
    Int J Radiat Oncol Biol Phys 64:374-81. 2006
    ..To study the safety and efficacy of dose escalation in tumor for locally advanced nasopharyngeal carcinoma (NPC)...
  36. ncbi A challenge to traditional radiation oncology
    Jack F Fowler
    Department of Human Oncology, Medical School of the University of Wisconsin, Madison, WI, USA
    Int J Radiat Oncol Biol Phys 60:1241-56. 2004
    ....
  37. ncbi Extending the linear-quadratic model for large fraction doses pertinent to stereotactic radiotherapy
    M Guerrero
    Department of Radiation Oncology, University of Maryland, Baltimore, MD 21201, USA
    Phys Med Biol 49:4825-35. 2004
    ..This work indicates that the standard LQ model can lead to erroneous results when used to calculate iso-effects with large fraction doses, such as those used for ESR. We present a solution to this problem...
  38. ncbi Acute toxicity after cyberknife-delivered hypofractionated radiotherapy for treatment of prostate cancer
    Natasa C Townsend
    Department of Radiation Oncology, Drexel University College of Medicine, Philadelphia, PA 19102, USA
    Am J Clin Oncol 34:6-10. 2011
    ..To evaluate acute toxicity outcomes of prostate cancer patients treated with CyberKnife-delivered hypofractionated radiotherapy...
  39. ncbi Validation of the RTOG recursive partitioning analysis (RPA) classification for brain metastases
    L E Gaspar
    University of Colorado Health Science Center, Denver, CO, USA
    Int J Radiat Oncol Biol Phys 47:1001-6. 2000
    ..An analysis of RTOG 91-04, a randomized study comparing two dose-fractionation schemes with a comparison to the established RTOG database, was considered important to validate the RPA classes...
  40. ncbi Twice-daily compared with once-daily thoracic radiotherapy in limited small-cell lung cancer treated concurrently with cisplatin and etoposide
    A T Turrisi
    Medical University of South Carolina, Charleston 29425, USA
    N Engl J Med 340:265-71. 1999
    ..Twice-daily accelerated thoracic radiotherapy has potential advantages over once-daily radiotherapy...
  41. ncbi Stereotactic hypofractionated accurate radiotherapy of the prostate (SHARP), 33.5 Gy in five fractions for localized disease: first clinical trial results
    Berit L Madsen
    Section of Radiation Oncology, Virginia Mason Medical Center, Seattle, WA 98101, USA
    Int J Radiat Oncol Biol Phys 67:1099-105. 2007
    ..To evaluate the feasibility and toxicity of stereotactic hypofractionated accurate radiotherapy (SHARP) for localized prostate cancer...
  42. ncbi Universal survival curve and single fraction equivalent dose: useful tools in understanding potency of ablative radiotherapy
    Clint Park
    Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9183, USA
    Int J Radiat Oncol Biol Phys 70:847-52. 2008
    ....
  43. pmc The UK Standardisation of Breast Radiotherapy (START) Trial A of radiotherapy hypofractionation for treatment of early breast cancer: a randomised trial
    S M Bentzen
    Lancet Oncol 9:331-41. 2008
    ..We tested two dose levels of a 13-fraction schedule against the standard regimen with the aim of measuring the sensitivity of normal and malignant tissues to fraction size...
  44. ncbi The linear-quadratic model is inappropriate to model high dose per fraction effects in radiosurgery
    John P Kirkpatrick
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Semin Radiat Oncol 18:240-3. 2008
    ....
  45. ncbi Stereotactic body radiotherapy for localized prostate cancer: interim results of a prospective phase II clinical trial
    Christopher R King
    Department of Radiation Oncology, Division of Urologic Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Int J Radiat Oncol Biol Phys 73:1043-8. 2009
    ..The radiobiology of prostate cancer favors a hypofractionated dose regimen. We report results of a prospective Phase II clinical trial of stereotactic body radiotherapy (SBRT) for localized prostate cancer...
  46. ncbi Radiation-induced rib fractures after hypofractionated stereotactic body radiation therapy of non-small cell lung cancer: a dose- and volume-response analysis
    Niclas Pettersson
    Department of Radiophysics, Sahlgrenska University Hospital, Sweden
    Radiother Oncol 91:360-8. 2009
    ..The aim of this study is to analyse the dose-response and the volume-response of radiation-induced rib fractures after hypofractionated stereotactic body radiation therapy (SBRT)...
  47. ncbi Fractionation for whole breast irradiation: an American Society for Radiation Oncology (ASTRO) evidence-based guideline
    Benjamin D Smith
    Department of Radiation Oncology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Int J Radiat Oncol Biol Phys 81:59-68. 2011
    ..However, it remains controversial whether these results apply to all subgroups of patients. We therefore developed an evidence-based guideline to provide direction for clinical practice...
  48. ncbi Escalated dose for non-small-cell lung cancer with accelerated hypofractionated three-dimensional conformal radiation therapy
    Pierre Thirion
    Department of Radiation Oncology, St Luke s Hospital, Highfield Road, Dublin 4, Ireland
    Radiother Oncol 71:163-6. 2004
    ..To prospectively assess the feasibility and efficacy of a hypofractionated accelerated radiotherapy regimen (72 Gy in 24 daily fractions, 3 Gy per fraction) in patients (pts) with non-resectable non-small-cell lung cancer (NSCLC)...
  49. ncbi Palliation of metastatic bone pain: single fraction versus multifraction radiotherapy--a systematic review of randomised trials
    W M Sze
    Departament of Clinical Oncology, Pamela Youde Nethersole Eastern Hospital, Chai Wan, Hong Kong, PR China
    Clin Oncol (R Coll Radiol) 15:345-52. 2003
    ..However, the re-treatment rate and pathological fracture rate were higher after single fraction radiotherapy. Studies with quality of life and health economic end points are warranted to find out the optimal treatment option...
  50. ncbi Accelerated hypofractionated intensity-modulated radiotherapy with concurrent and adjuvant temozolomide for patients with glioblastoma multiforme: a safety and efficacy analysis
    Valerie Panet-Raymond
    Department of Oncology, Division of Radiation Oncology, McGill University, Montreal, QC, Canada
    Int J Radiat Oncol Biol Phys 73:473-8. 2009
    ..In an attempt to improve results, we have begun a program of accelerated hypofractionated intensity-modulated radiotherapy (hypo-IMRT) with concomitant and adjuvant temozolomide (TMZ)...
  51. ncbi High-dose-rate prostate brachytherapy: an excellent accelerated-hypofractionated treatment for favorable prostate cancer
    Alvaro A Martinez
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Am J Clin Oncol 33:481-8. 2010
    ..The 5-year experience at William Beaumont Hospital (WBH) and the California Endocurietherapy Center (CET) with accelerated-hypofractionated high-dose-rate (HDR) monotherapy in favorable prostate cancer is presented...
  52. ncbi Combination external beam radiotherapy and high-dose-rate intracavitary brachytherapy for uterine cervical cancer: analysis of dose and fractionation schedule
    Takafumi Toita
    Department of Radiology, University of the Ryukyus School of Medicine, Okinawa, Japan
    Int J Radiat Oncol Biol Phys 56:1344-53. 2003
    ..To determine an appropriate dose and fractionation schedule for a combination of external beam radiotherapy (EBRT) and high-dose-rate intracavitary brachytherapy (HDR-ICBT) for uterine cervical cancer...
  53. ncbi Mechanistic formulation of a lineal-quadratic-linear (LQL) model: split-dose experiments and exponentially decaying sources
    Mariana Guerrero
    Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, 21201, USA
    Med Phys 37:4173-81. 2010
    ..This model provides a comprehensive description of radiation response for arbitrary dose rate and fractionation with only one additional parameter...
  54. ncbi A phase II trial of accelerated hypofractionated three-dimensional conformal radiation therapy in locally advanced non-small cell lung cancer
    Zheng Fei Zhu
    Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Fudan University, 270 Dong An Road, Shanghai, China
    Radiother Oncol 98:304-8. 2011
    ..The aim of this study is to evaluate the safety and efficacy of accelerated hypofractionated radiotherapy (HypoRT) combined with sequential chemotherapy in locally advanced non-small cell lung cancer (NSCLC)...
  55. ncbi Short-course intensity-modulated radiotherapy (70 GY at 2.5 GY per fraction) for localized prostate cancer: preliminary results on late toxicity and quality of life
    P A Kupelian
    Department of Radiation Oncology, Cleveland Clinic Foundation, OH 44195, USA
    Int J Radiat Oncol Biol Phys 51:988-93. 2001
    ..To present our preliminary observations on the late toxicity and quality of life (QOL) of patients treated with short-course intensity-modulated radiotherapy (SCIM-RT)...
  56. ncbi GEC/ESTRO-EAU recommendations on temporary brachytherapy using stepping sources for localised prostate cancer
    Gyorgy Kovacs
    Interdisciplinary Brachytherapy Centre, University Hospital Schleswig Holstein Campus Kiel, Arnold Heller Str 9, D 24105 Kiel, Germany
    Radiother Oncol 74:137-48. 2005
    ..Experts in prostate brachytherapy developed these recommendations on behalf of the GEC/ESTRO and of the EAU. The paper has been approved by both GEC/ESTRO steering committee members and EAU committee members...
  57. ncbi New radiotherapy and chemoradiotherapy approaches for non-small-cell lung cancer
    Joseph K Salama
    Duke University, Durham, NC, USA
    J Clin Oncol 31:1029-38. 2013
    ..As modern radiotherapy techniques have been shown to improve outcomes of some patients with limited metastatic disease, investigations are ongoing regarding how to optimally integrate them with standard chemotherapy platforms...
  58. pmc Dosimetry and preliminary acute toxicity in the first 100 men treated for prostate cancer on a randomized hypofractionation dose escalation trial
    Alan Pollack
    Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Int J Radiat Oncol Biol Phys 64:518-26. 2006
    ..The dosimetry and acute toxicity are described in the first 100 men enrolled in a randomized trial...
  59. ncbi Adaptive-predictive organ localization using cone-beam computed tomography for improved accuracy in external beam radiotherapy for bladder cancer
    Susan Lalondrelle
    Academic Urology Unit, Department of Radiotherapy, Royal Marsden NHS Foundation Trust, Sutton, UK
    Int J Radiat Oncol Biol Phys 79:705-12. 2011
    ..To examine patterns of bladder wall motion during high-dose hypofractionated bladder radiotherapy and to validate a novel adaptive planning method, A-POLO, to prevent subsequent geographic miss...
  60. ncbi Two-year results from a Swedish study on conventional versus accelerated radiotherapy in head and neck squamous cell carcinoma--the ARTSCAN study
    Björn Zackrisson
    Umea University Hospital, Sweden
    Radiother Oncol 100:41-8. 2011
    ..In 1998 a national Swedish group decided to perform a randomised controlled clinical study of AF...
  61. ncbi Stereotactic body radiotherapy for primary lung cancer at a dose of 50 Gy total in five fractions to the periphery of the planning target volume calculated using a superposition algorithm
    Atsuya Takeda
    Department of Radiology, Ofuna Chuo Hospital, Kamakura, Japan Department of Radiology, Tokyo Metropolitan Hiroo General Hospital, Tokyo, Japan
    Int J Radiat Oncol Biol Phys 73:442-8. 2009
    ..To retrospectively analyze the clinical outcomes of stereotactic body radiotherapy (SBRT) for patients with Stages 1A and 1B non-small-cell lung cancer...
  62. pmc Hypofractionation for prostate cancer
    Mark Ritter
    Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
    Cancer J 15:1-6. 2009
    ..With hypofractionation's significant potential for therapeutic gain, cost savings, and improved patient convenience, the future management of localized prostate cancer could be profoundly altered in the process...
  63. ncbi Radiation therapy in the management of childhood brain tumors
    J L Habrand
    Department of Radiation Oncology, Institut Gustave Roussy, Villejuif, France
    Childs Nerv Syst 17:121-33. 2001
    ....
  64. pmc A modified Phase I trial of radiation dose escalation in 3D conformal radiation therapy with concurrent vinorelbine and carboplatin chemotherapy for non-small-cell lung cancer
    Qiang Lin
    Department of Oncology, Hebei Medical University North China Petroleum Bureau General Hospital, 8 Huizhan Avenue, Renqiu 062552, Hebei, China
    J Radiat Res 54:126-34. 2013
    ..A further evaluation of this regimen in a prospective Phase II trial is ongoing...
  65. ncbi Feasibility and acute toxicity of hypofractionated radiation in large-breasted patients
    Paige L Dorn
    Department of Radiation and Cellular Oncology, University of Chicago Hospitals, Chicago, IL, USA
    Int J Radiat Oncol Biol Phys 83:79-83. 2012
    ....
  66. ncbi Results of a phase I dose-escalation study using single-fraction stereotactic radiotherapy for lung tumors
    Quynh Thu Le
    Department of Radiation Oncology, Stanford University, Stanford, California, USA
    J Thorac Oncol 1:802-9. 2006
    ..The purpose of this study was to report initial results of a phase I study using single-fraction stereotactic radiotherapy (RT) in patients with inoperable lung tumors...
  67. ncbi Effectiveness of brachytherapy and fractionated stereotactic radiotherapy boost for persistent nasopharyngeal carcinoma
    Tsz Kok Yau
    Department of Clinical Oncology, Pamela Youde Nethersole Eastern Hospital, 3 Lok Man Road, Chai Wan, Hong Kong
    Head Neck 26:1024-30. 2004
    ..We compared the effectiveness of brachytherapy and a fractionated stereotactic radiotherapy (SRT) boost in improving tumor control...
  68. ncbi Modelling of post-irradiation accelerated repopulation in squamous cell carcinomas
    L Marcu
    School of Chemistry and Physics, University of Adelaide, Adelaide, Australia
    Phys Med Biol 49:3767-79. 2004
    ..A more significant contribution was provided through the multiplication of surviving tumour stem cells during radiotherapy, by reducing their cell cycle time, and due to loss of asymmetry of stem cell division...
  69. ncbi Efficient Monte Carlo modelling of individual tumour cell propagation for hypoxic head and neck cancer
    W Tuckwell
    School of Chemistry and Physics, University of Adelaide, South Australia, Australia
    Phys Med Biol 53:4489-507. 2008
    ....
  70. ncbi Stereotactic body radiotherapy and gemcitabine for locally advanced pancreatic cancer
    Anand Mahadevan
    Department of Radiation Oncology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Int J Radiat Oncol Biol Phys 78:735-42. 2010
    ..We explored the safety and effectiveness of a 3-day course of hypofractionated stereotactic body radiotherapy (SBRT) followed by gemcitabine in this population...
  71. ncbi Early outcomes from three prospective trials of image-guided proton therapy for prostate cancer
    Nancy P Mendenhall
    University of Florida Proton Therapy Institute, Jacksonville, FL 32206, USA
    Int J Radiat Oncol Biol Phys 82:213-21. 2012
    ..To report early outcomes with image-guided proton therapy for prostate cancer...
  72. ncbi Daily image guidance with cone-beam computed tomography for head-and-neck cancer intensity-modulated radiotherapy: a prospective study
    Robert B Den
    Department of Radiation Oncology, Thomas Jefferson University Hospital, Philadelphia, PA 19107 5097, USA
    Int J Radiat Oncol Biol Phys 76:1353-9. 2010
    ....
  73. ncbi Phase II trial of hypofractionated stereotactic radiotherapy for brain metastases: results and toxicity
    Antje Ernst-Stecken
    Department of Radiation Therapy and Novalis Shaped Beam Surgery Center, University of Erlangen, Germany
    Radiother Oncol 81:18-24. 2006
    ..To prospectively evaluate efficacy and side effects of hypofractionated stereotactic radiotherapy (hfSRT) for irresectable brain metastases not amenable to radiosurgery (SRS)...
  74. pmc Monte Carlo radiotherapy simulations of accelerated repopulation and reoxygenation for hypoxic head and neck cancer
    W M Harriss-Phillips
    Department of Medical Physics, Royal Adelaide Hospital Cancer Centre, Adelaide, SA, Australia
    Br J Radiol 84:903-18. 2011
    ..The model was designed to simulate individual cell division up to 10(8) cells, while incorporating radiobiological effects, including accelerated repopulation and reoxygenation during treatment...
  75. ncbi Adaptive replanning strategies accounting for shrinkage in head and neck IMRT
    Qiuwen Wu
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI, USA
    Int J Radiat Oncol Biol Phys 75:924-32. 2009
    ..The purposes of this study were (1) to evaluate the differences between planned and delivered dose, (2) to investigate margins required for anatomic changes, and (3) to find optimal replanning strategies...
  76. ncbi Stereotactic body radiation therapy for abdominal targets using volumetric intensity modulated arc therapy with RapidArc: feasibility and clinical preliminary results
    Marta Scorsetti
    IRCCS Istituto Clinico Humanitas, Rozzano Milano, Italy
    Acta Oncol 50:528-38. 2011
    ..To report early clinical experience in stereotactic body radiation therapy (SBRT) delivered using volumetric intensity modulated arc therapy with RapidArc (RA) in patients with primary or metastatic tumours at abdominal sites...
  77. ncbi Patterns of failure in patients receiving definitive and postoperative IMRT for head-and-neck cancer
    K S Clifford Chao
    Department of Radiation Oncology, Washington University Medical School, St Louis, MO, USA
    Int J Radiat Oncol Biol Phys 55:312-21. 2003
    ..To analyze the patterns of locoregional failure in patients with head-and-neck cancer treated with inverse planning intensity-modulated radiotherapy (IMRT)...
  78. ncbi Prognostic factors in stereotactic body radiotherapy for non-small-cell lung cancer
    Yukinori Matsuo
    Department of Radiation Oncology and Image Applied Therapy, Graduate School of Medicine, Kyoto University, Sakyo ku, Kyoto, Japan
    Int J Radiat Oncol Biol Phys 79:1104-11. 2011
    ..To investigate the factors that influence clinical outcomes after stereotactic body radiotherapy (SBRT) for non-small-cell lung cancer (NSCLC)...
  79. pmc Effects of proton radiation dose, dose rate and dose fractionation on hematopoietic cells in mice
    J H Ware
    Department of Radiation Oncology, Division of Oncology Research, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6072, USA
    Radiat Res 174:325-30. 2010
    ....
  80. ncbi Hypofractionated stereotactic radiotherapy for the treatment of brain metastases
    Alexander K Kwon
    Department of Radiation Oncology, Cooper University Hospital, Camden, New Jersey, USA
    Cancer 115:890-8. 2009
    ..This retrospective review evaluated the efficacy and toxicity profiles of various dose fractionations using hypofractionated stereotactic radiotherapy (HSRT) in the treatment of brain metastases...
  81. ncbi Stereotactic body radiotherapy for medically inoperable lung cancer: prospective, single-center study of 108 consecutive patients
    Mojgan Taremi
    Radiation Medicine Program, Princess Margaret Hospital, Toronto, ON, Canada
    Int J Radiat Oncol Biol Phys 82:967-73. 2012
    ..To present the results of stereotactic body radiotherapy (SBRT) for medically inoperable patients with Stage I non-small-cell lung cancer (NSCLC) and contrast outcomes in patients with and without a pathologic diagnosis...
  82. ncbi Critical appraisal of volumetric modulated arc therapy in stereotactic body radiation therapy for metastases to abdominal lymph nodes
    Mario Bignardi
    Istituto Clinico Humanitas, Radiation Oncology, Rozzano, Italy
    Int J Radiat Oncol Biol Phys 75:1570-7. 2009
    ....
  83. ncbi Combined proton and photon conformal radiotherapy for intracranial atypical and malignant meningioma
    Christos Boskos
    Institut Curie, Centre de protonthérapie d Orsay, Campus Universitaire, Orsay, France
    Int J Radiat Oncol Biol Phys 75:399-406. 2009
    ..To evaluate retrospectively the efficacy of conformal fractionated radiotherapy combining proton and photon beams after primary surgery for treatment of atypical and malignant meningiomas...
  84. ncbi Altered fractionation in radiotherapy: from radiobiological rationale to therapeutic gain
    Loredana G Marcu
    University of Oradea, Faculty of Science, Romania
    Cancer Treat Rev 36:606-14. 2010
    ....
  85. ncbi Post mastectomy adjuvant radiotherapy in breast cancer: a comparision of three hypofractionated protocols
    Abubaker Shahid
    Institute of Nuclear Medicine and Oncology INMOL, Wahdat Road, Lahore, Pakistan
    J Pak Med Assoc 59:282-7. 2009
    ..To compare three hypofractionated protocols in postmastectomy cancinoma breast in terms of local control, toxicity and work load...
  86. doi An overview of hypofractionation and introduction to this issue of seminars in radiation oncology
    Robert D Timmerman
    Semin Radiat Oncol 18:215-22. 2008
  87. ncbi Fractionated proton beam irradiation of pituitary adenomas
    Brian B Ronson
    Department of Radiation Medicine, Loma Linda University Medical Center, Loma Linda, CA 92354, USA
    Int J Radiat Oncol Biol Phys 64:425-34. 2006
    ..Various radiation techniques and modalities have been used to treat pituitary adenomas. This report details our experience with proton treatment of these tumors...
  88. pmc Anaplastic thyroid carcinoma: three protocols combining doxorubicin, hyperfractionated radiotherapy and surgery
    J Tennvall
    Department of Oncology, Lund University Hospital, SE 221 85 Lund, Sweden
    Br J Cancer 86:1848-53. 2002
    ..017). In the 40 patients undergoing additional surgery, no signs of local recurrence were seen in 5 out of 9 patients, 11 out of 14 patients and 17 out of 17 patients, respectively (P=0.005)...
  89. ncbi The role of fractionated radiotherapy and radiosurgery in the management of patients with craniopharyngioma
    G Minniti
    Department of Radiotherapy Oncology, Sant Andrea Hospital, University La Sapienza, Via di Grottarossa 1035, 00189, Rome, Italy
    Neurosurg Rev 32:125-32; discussion 132. 2009
    ..Longer follow-up is necessary to confirm the excellent tumor control and the potential reduction of long-term radiation toxicity...
  90. pmc Use of normal tissue complication probability models in the clinic
    Lawrence B Marks
    Department of Radiation Oncology, University of North Carolina, Chapel Hill, NC 27514, USA
    Int J Radiat Oncol Biol Phys 76:S10-9. 2010
    ..A summary of organ-specific dose/volume/outcome data, based on the QUANTEC reviews, is included...
  91. ncbi Interobserver variability of clinical target volume delineation of glandular breast tissue and of boost volume in tangential breast irradiation
    Henk Struikmans
    Department of Radiotherapy, University Medical Centre, Ultrecht, The Netherlands
    Radiother Oncol 76:293-9. 2005
    ..To determine the interobserver variability of clinical target volume delineation of glandular breast tissue and of boost volume in tangential breast irradiation...
  92. ncbi Phase II trial of hypofractionated image-guided intensity-modulated radiotherapy for localized prostate adenocarcinoma
    Jarad M Martin
    Department of Radiation Oncology, Princess Margaret Hospital, University of Toronto, Toronto, ON, Canada
    Int J Radiat Oncol Biol Phys 69:1084-9. 2007
    ..To assess in a prospective trial the feasibility and late toxicity of hypofractionated radiotherapy (RT) for prostate cancer...
  93. ncbi Delayed radiation-induced myelopathy after spinal radiosurgery
    Iris C Gibbs
    Department of Radiation Oncology, Stanford University Medical Center, Stanford, California 94305 5847, USA
    Neurosurgery 64:A67-72. 2009
    ..We report a case series of 6 patients treated with radiosurgery who developed delayed myelopathy...
  94. ncbi Results of radiotherapy for T2N0 glottic carcinoma: does the "2" stand for twice-daily treatment?
    Adam S Garden
    Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Int J Radiat Oncol Biol Phys 55:322-8. 2003
    ..This retrospective study updated the results of RT for patients treated at our center. The primary focus of this study was whether a policy of using hyperfractionated RT for these patients resulted in a therapeutic gain...
  95. ncbi Treatment of nasopharyngeal carcinoma using intensity-modulated radiotherapy-the national cancer centre singapore experience
    Ivan Weng Keong Tham
    Department of Radiation Oncology, National Cancer Centre, Singapore
    Int J Radiat Oncol Biol Phys 75:1481-6. 2009
    ..The aim of this study was to determine the efficacy and acute toxicity of our early experience with treating nasopharyngeal carcinoma (NPC) patients with intensity-modulated radiotherapy (IMRT)...
  96. ncbi Improved tumor targeting of radiolabeled RGD peptides using rapid dose fractionation
    Marcel Janssen
    Department of Nuclear Medicine, University Medical Center Nijmegen, The Netherlands
    Cancer Biother Radiopharm 19:399-404. 2004
    ..These studies aimed to investigate whether tumor targeting and tumor therapy could be optimized by dose fractionation. The RGD-peptide DOTA-E-[c(RGDfK)]2 was labeled with 111In for biodistribution experiments and with 90Y for ..
  97. ncbi Accelerated treatment of breast cancer
    F A Vicini
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    J Clin Oncol 19:1993-2001. 2001
    ..The goals of the study were to determine whether treatment time can be reduced and whether elective treatment of the entire breast is necessary...
  98. ncbi What hypofractionated protocols should be tested for prostate cancer?
    Jack F Fowler
    Department of Human Oncology, University of Wisconsin Madison, Madison, WI 53792, USA
    Int J Radiat Oncol Biol Phys 56:1093-104. 2003
    ..We analyze here possible high-gain/low-risk hypofractionated protocols for prostate cancer to test this suggestion...
  99. pmc Normal tissue toxicity after small field hypofractionated stereotactic body radiation
    Michael T Milano
    Department of Radiation Oncology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Radiat Oncol 3:36. 2008
    ..While clinical data has shown SBRT to be safe in most circumstances, more data is needed to refine the ideal dose-volume metrics...
  100. pmc Safety and efficacy of bevacizumab with hypofractionated stereotactic irradiation for recurrent malignant gliomas
    Philip H Gutin
    Department of Neurosurgery, The Brain Tumor Center, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    Int J Radiat Oncol Biol Phys 75:156-63. 2009
    ..The objectives of this study were to determine the safety and activity of this combination in malignant gliomas...
  101. ncbi Hypofractionated stereotactic radiotherapy using intensity-modulated radiotherapy in patients with one or two brain metastases
    Ashwatha Narayana
    Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, Weill Medical College of Cornell University, New York, NY, USA
    Stereotact Funct Neurosurg 85:82-7. 2007
    ....

Research Grants63

  1. Co-Delivery of Antifungal Agents: Toxicity and Efficacy in Invasive Candidiasis
    Glen S Kwon; Fiscal Year: 2013
    ..for established and novel combinations of antifungal agents are ill-defined in terms of dose selection, dose fractionation, predictive PD index (PDI), and post-antibiotic effect (PAE) in relation to treatment efficacy and host ..
  2. Blood-Brain Barrier Disruption in Blast Neurotrauma
    AMANDA DAWN GAUDREAU-BALDERRAMA; Fiscal Year: 2013
    ..Insights gained from this work will stimulate further development of MIMS technology for biomedical research and accelerate translational development of urgently needed diagnostics and therapeutics for blast-related TBI and CTE. ..
  3. Rescuing radiation-induced cognitive deficits through cranial transplantation of
    Charles Limoli; Fiscal Year: 2013
    ..following Specific Aims: 1) determine if the effectiveness of stem cell transplantation depends on dose or dose fractionation, 2) determine the optimal post-irradiation transplantation time for restoration of impaired cognition, 3) ..
  4. Rhenium-188 therapy of NIS-expressing breast tumors
    Ekaterina Dadachova; Fiscal Year: 2003
    ..We also hypothesize that the combination of dose fractionation/normal organ protection will increase 188-Re tumodcidal effect while decreasing the radiation dose to normal ..
  5. HYPERTHERMIA AND PERFUSION EFFECTS IN CANCER THERAPY
    Mark Dewhirst; Fiscal Year: 2009
    ..Project 4 will examine the relationship between thermal dose fractionation, tumor physiologic change and treatment outcome in dogs with spontaneous soft tissue sarcomas treated with ..
  6. TRANSFORMATION IN VITRO WITH SPLIT DOSES OF RADIATION
    Richard Miller; Fiscal Year: 1980
    ..Recently developed methods of in vitro oncogenic transformation are being used to investigate the effect of dose fractionation and variations in dose-rate, both for x-rays and for cyclotron produced neutrons...
  7. RADIATION INDUCED HEPATIC INJURY
    Joseph Geraci; Fiscal Year: 1991
    ..Radiation dose fractionation studies will be performed to measure time dependent recovery processes (e.g...
  8. MODULATION OF COLON CARCINOGENESIS BY CHLOROPHYLLIN
    Roderick Dashwood; Fiscal Year: 2000
    ..Finally, several intermediate biomarkers associated with the post-initiation phase of colon carcinogenesis will be examined to provide insight into the possible mechanisms of tumor promotion by CHL. ..
  9. EXPERIMENTAL RADIOTHERAPY - CELLULAR RESPONSES IN VIVO
    Amato Giaccia; Fiscal Year: 1993
    ..and by cytotoxic drugs; determine microcolony abortion probabilities; determine whether the mode of X-ray dose fractionation affects growth kinetics of surviving clonogenic tumor cells; and provide data on the kinetics of cell death ..
  10. EFFECTS OF HYPERFRACTIONATED RADIATION ON BONE GROWTH
    Patricia Eifel; Fiscal Year: 1990
    ..Development and application of morphometric techniques to determine radiation dose-response relationships in this complex system may provide a useful tool for the analysis of radiation-induced normal tissue damage in general...
  11. INTERNATIONAL CONFERENCE ON TIME/DOSE/FRACTIONATION
    Bhudatt Paliwal; Fiscal Year: 1992
    ..The relevance of the above to clinical procedures will be emphasized. Evening workshops will provide tutorials in the basics, as well as providing a forum for discussion and identification of issues needing further investigation...
  12. RESPONSE OF BRAIN TO RADIATION
    William McBride; Fiscal Year: 1991
    ..They are particularly inadequate for predicting how the brain will respond to dose fractionation in particular at doses of less than or equal to 2 Gy...
  13. RESPONSE OF SPINAL CORD TO LOW RADIATION DOSES
    H Withers; Fiscal Year: 1991
    The radiation dose response characteristics of the spinal cord will be investigated for dose fractionation regimens using fractional doses between 1 and 4 Gy...
  14. GROWTH PLATE CELLULAR FUNCTION FOLLOWING RADIOTHERAPY
    Timothy Damron; Fiscal Year: 2008
    ..abstract_text> ..
  15. TUMOR OXYGENATION, VASCULARIZATION, AND RADIORESPONSE
    Bruce Fenton; Fiscal Year: 2009
    ..These results with lead to the more rational and optimal design of effective combined therapies, thereby ultimately accelerating their implementation into clinical protocols. ..
  16. Defining Molecular Markers for Tumor Hypoxia
    QUYNH THU XUAN LE; Fiscal Year: 2010
    ..abstract_text> ..
  17. RADIOLOGICAL RESEARCH ACCELERATOR FACILITY (RARAF)
    David Brenner; Fiscal Year: 2002
    ..abstract_text> ..
  18. High Stability Accelerator for Sub-Cellular Microbeam
    David Brenner; Fiscal Year: 2003
    ..We have considerably more demand for microbeam time than we can cope with, primarily because of limited physicist manpower. ..
  19. MONTE CARLO DOSIMETRY FOR INTRAVASCULAR BRACHYTHERAPY
    X Li; Fiscal Year: 2002
    ..abstract_text> ..
  20. Laser acceleration of protons for radiation therapy
    Dale Litzenberg; Fiscal Year: 2007
    ..This research will conduct the first critical step in determining if the cost can be dramatically reduced through the use of new acceleration technology. [unreadable] [unreadable] [unreadable]..
  21. Cancer Risks Attributable To Radiation from Pediatric CT
    David Brenner; Fiscal Year: 2006
    ..The target audiences will be radiologists, pediatricians, family physicians, and the CT industry. We will use telephone interviews supplemented with survey questions, to aid in web content decisions. ..
  22. Biomarkers of Prostate Cancer Radiation Outcome
    Mark Ritter; Fiscal Year: 2007
    ..abstract_text> ..
  23. Hypofractionated IMRT for Localized Prostate Cancer
    Mark Ritter; Fiscal Year: 2008
    ..abstract_text> ..
  24. IMRT in the Treatment of Node-Positive Breast Cancer
    Lori Pierce; Fiscal Year: 2006
    ..3) Study 60 patients treated with either the best delivery-optimized motion corrected plan from Aim 2 or PWTF and compare plans using heart and lung metrics. ..
  25. Gulf Coast MBCCOP
    Paul Schwarzenberger; Fiscal Year: 2007
    ..Genesis of the MBCCOP at MIMC was associated with increased accrual to NCI supported research over previous years. ..
  26. Temporal Variation of Organ Dose Distribution in RT
    Di Yan; Fiscal Year: 2007
    ..Explore practical methods to include temporal variation of organ dose distribution, estimated from image feedback, in treatment planning optimization. ..
  27. Rescue of radiation-induced salivary gland dysfunction by Akt
    KIRSTEN LIMESAND; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  28. Spectral-Encoding for Video-Rate Hemodynamic Tomography
    Brian Pogue; Fiscal Year: 2007
    ..abstract_text> ..
  29. Dose-Volume Modeling of Late Rectal and Bladder Toxicity
    Susan Tucker; Fiscal Year: 2007
    ..We expect the results of our analyses to play an important role in furthering the development of conformal techniques in RT of the prostate and other pelvic sites. ..
  30. Functional Infrared Imaging Predicts Radiation Mucositis
    Ezra Cohen; Fiscal Year: 2008
    ..Such a tool would have wide applicability in this patient population and would have tremendous impact on their treatment. [unreadable] [unreadable] [unreadable]..
  31. PHASE I TRIALS OF ANTICANCER AGENTS
    Martin Edelman; Fiscal Year: 2002
    ....
  32. 9/10TH Conf./Cancer Therapy/Antibody/Immunoconjugates
    David Goldenberg; Fiscal Year: 2004
    ..The conference chairman, Dr. Goldenberg, has secured two outstanding scientists as co-chairmen, Drs. Ralph Reisfeld (Scripps) and Edward Sausville (NCI). ..
  33. Damage signaling from irradiated to non-irradiated cells
    EDOUARD AZZAM; Fiscal Year: 2004
    ..They are also relevant to diagnostic and therapeutic nuclear medicine where radionuclides are being investigated to detect various diseases and treat cancer. ..
  34. Beta glucan enhances antibody therapy for neuroblastoma
    Nai Kong Cheung; Fiscal Year: 2003
    ..These findings will have general implications for antibody and vaccine strategies in human cancer models, and the role of polysaccharides as complementary/herbal medicine in immune-based therapies. ..
  35. AT: ERRORS IN DOUBLE STRAND BREAK REPAIR
    Simon Powell; Fiscal Year: 2003
    ..Functional analysis will address the relationship between the NBS- containing protein complex and ATM in a DNA damage response pathway. ..
  36. Suppression of Salivary Gland Apoptosis by AKt
    KIRSTEN LIMESAND; Fiscal Year: 2003
    ..These studies will provide greater insight to the understanding of this tissue and potentially provide clinical treatment of cancer-induced apoptosis in salivary glands. ..
  37. GENETIC INFLUENCE ON MUTAGEN SENSITIVITY--A TWIN STUDY
    Xifeng Wu; Fiscal Year: 2004
    ..Additionally, these potential biomarkers may ultimately be used to identify individuals who should be targeted for more intense screening programs or behavior modification interventions. ..
  38. Cytokines in radiation lung injury
    ARTHUR BLACKSTOCK; Fiscal Year: 2003
    ..Even further, understanding the temporal expression of MIP-1alpha during thoracic radiation may allow the future utilization of anticytokine reagents, e.g. antibodies, receptor and synthesis blockers during treatment. ..
  39. CMMI Human Subject Research Enhancement Program
    David Goldenberg; Fiscal Year: 2002
    ..3.) Provide travel expenses and educational materials for IRB members, investigators, and Regulatory Affairs Office personnel to attend meetings for educational enhancement. ..
  40. SUPERHEATED DROP DETECTORS FOR DOSIMETRY IN RADIOTHERAPY
    Ravinder Nath; Fiscal Year: 2001
    ..The research plan will attempt to exploit the many unique features of the SEC, namely its reusability, high sensitivity and LET discrimination. ..
  41. GENETIC ANALYSIS OF HEREDITARY MACROTHROMBOCYTOPENIAS
    Michael Kelley; Fiscal Year: 2002
    ..When the causative gene is identified, biochemical and physiological analysis will be pursued including development of a murine model of the disease. ..
  42. DNA Recombinational Repair: Role of the p53 Tumor Suppressor Protein
    Simon N Powell; Fiscal Year: 2010
    ....
  43. PRE-CLINICAL STUDIES OF SPINAL-CORD INJURY REPAIR
    Nurit Kalderon; Fiscal Year: 2004
    ..g., dose protocol) at which repair is facilitated. Analysis of repair is conducted using magnetic resonance imaging of the lesion site at the cord, quantitative histologic and electrophysiologic methods and behavioral methods. ..
  44. HIGH ENERGY IONS AND GENOMIC INSTABILITY
    Eric Hall; Fiscal Year: 2001
    ....
  45. 4D Visible Human Modeling for Radiation Dosimetry
    Xie George Xu; Fiscal Year: 2010
    ..4).To establish an internet-based information-sharing resource on virtual-human motion simulation and radiation dosimetry. ..
  46. Deformable image registration and reconstruction for radiotherapy applications
    Martin J Murphy; Fiscal Year: 2010
    ..The third aim of the project is to develop measurement and validation procedures to assess the accuracy and reliability of these novel image registration and reconstruction techniques. ..
  47. Quantifying Human Lung Tissue Dose Response Relationship
    WALTER O DELL; Fiscal Year: 2008
    ..Our proposal includes graded lung irradiation experiments in animal models to validate and link our imaging results to prior knowledge of cellular and tissue radiobiology. [unreadable] [unreadable] [unreadable]..
  48. CANCER AND LEUKEMIA GROUP B
    Martin Edelman; Fiscal Year: 2002
    ..The grant will also allow for continuation of meritorious pilot protocols and will allow GCC to monitor and collect data which will produce mutual benefit to the GCC and CALGB. ..
  49. Use of Radiation in Stage IV Non-Small Cell Lung Cancer
    James Hayman; Fiscal Year: 2003
    ..Lastly, we plan to examine whether the frequency and intensity of the administration of treatment with palliative radiation in this patient population has changed over time. ..
  50. SUPERHEATED DROP DETECTORS FOR DOSIMETRY IN RADIOTHERAPY
    Ravinder Nath; Fiscal Year: 2005
    ..A Petri-dish-like micro SEC will be developed for the determination of doses at the interface of high Z materials and tissues with capability of measuring doses averaged over layers of about 10 pm thickness. ..
  51. Electromagnetic Tracking of Tumors for Radiotherapy
    Martin Murphy; Fiscal Year: 2006
    ..The augmented Calypso targeting system will be designed for integration into existing radiation therapy systems to provide enhanced beam targeting capability. [unreadable] [unreadable]..
  52. CARDINAL BERNARDIN CANCER CENTER, LOYOLA UNIVERSITY
    Patrick Stiff; Fiscal Year: 2002
    ..At the completion of this grant, the Cardinal Bernardin Cancer Center plans to be positioned to successfully apply for a P-30 Cancer Center Support Grant. ..
  53. Virtual Patients for Computing Radiation Doses
    Xie Xu; Fiscal Year: 2007
    ..These two cores then support four parallel clinical projects. [unreadable] [unreadable] [unreadable]..
  54. A novel set of molecular markers to measure metastatic neuroblastoma
    Nai Kong Cheung; Fiscal Year: 2007
    ..Armed with the tools to collect samples expeditiously and to measure MRD accurately, the paradigm of treating subclinical NB can then be tested in multicenter randomized studies. [unreadable] [unreadable]..
  55. Yeast Gene Ontology by Phenotypic Profiling
    John Brown; Fiscal Year: 2007
    ..abstract_text> ..
  56. 11th & 12th Conference on Cancer Therapy with Antibodies and Immunoconjugates
    David Goldenberg; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  57. Measurement of Hypoxia in Non Small Cell Lung Carcinoma
    Michael Kelley; Fiscal Year: 2003
    ..We believe the data from this pilot study will be useful to design future study(ies) with clinical endpoints and to guide selection of subjects for novel hypoxia-directed therapies in patients with NSCLC...
  58. RELEVANCE OF GENOMIC ALTERATIONS IN COLORECTAL CANCER
    Walter Curran; Fiscal Year: 2004
    ..This work will enhance our understanding of the complex events in the MMR-pathway and also provide new diagnostic and prognostic methodologies to test in colorectal tumors. ..
  59. EXPERIMENTAL RADIOTHERAPY--BASIS AND MODIFICATION
    John Brown; Fiscal Year: 2002
    ..To test this hypothesis we will employ inhibitors of the topo II catalytic cycle as well as cells induced to express high levels of topo II following TPZ treatment ..
  60. Digital tomosynthesis: a new paradigm for radiation treatment verification
    Fang Fang Yin; Fiscal Year: 2008
    ..This more frequent and broader range of application will translate into more consistent elimination of tumor and into less damage to nearby healthy tissue. [unreadable] [unreadable] [unreadable]..
  61. Image-guided radiation therapy of prostate cancer
    Qiuwen Wu; Fiscal Year: 2009
    ..The adoption of image guidance will allow significantly increased local control and reduced radiation induced complications in prostate cancer patients. ..