radiosurgery

Summary

Summary: A stereotactic neurosurgery in which the usual rigid needles or probes are replaced with beams of ionizing radiation directed toward an intracranial target so as to achieve local tissue destruction. No skin incision or skull opening is required. It is performed with the "gamma knife", a self-contained unit with 201 cobalt-60 sources or with an isocentric linear accelerator (linac). (Goodman, M.L., Southern Medical Journal, vol. 83, May 1990, pp. 551-4)

Top Publications

  1. ncbi Hypofractionated stereotactic body radiotherapy in low-risk prostate adenocarcinoma: preliminary results of a multi-institutional phase 1 feasibility trial
    Sean M McBride
    Harvard Radiation Oncology Program, Harvard University, 100 Blossom Street, 3, Boston, MA 02114, USA
    Cancer 118:3681-90. 2012
  2. pmc Stereotactic body radiation therapy for inoperable early stage lung cancer
    Robert Timmerman
    Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    JAMA 303:1070-6. 2010
  3. ncbi Whole brain radiation therapy with or without stereotactic radiosurgery boost for patients with one to three brain metastases: phase III results of the RTOG 9508 randomised trial
    David W Andrews
    Department of Neurosurgery, Thomas Jefferson University Hospital, Philadelphia, PA 19107, USA
    Lancet 363:1665-72. 2004
  4. pmc Adjuvant whole-brain radiotherapy versus observation after radiosurgery or surgical resection of one to three cerebral metastases: results of the EORTC 22952-26001 study
    Martin Kocher
    University of Cologne, Cologne, Germany
    J Clin Oncol 29:134-41. 2011
  5. ncbi Neurocognition in patients with brain metastases treated with radiosurgery or radiosurgery plus whole-brain irradiation: a randomised controlled trial
    Eric L Chang
    Department of Radiation Oncology, The University of Texas, M D Anderson Cancer Center, Houston, TX, USA
    Lancet Oncol 10:1037-44. 2009
  6. ncbi A European Organisation for Research and Treatment of Cancer phase III trial of adjuvant whole-brain radiotherapy versus observation in patients with one to three brain metastases from solid tumors after surgical resection or radiosurgery: quality-of-life
    Riccardo Soffietti
    University of Torino and San Giovanni Battista Hospital, Turin, Italy
    J Clin Oncol 31:65-72. 2013
  7. ncbi Stereotactic radiosurgery plus whole-brain radiation therapy vs stereotactic radiosurgery alone for treatment of brain metastases: a randomized controlled trial
    Hidefumi Aoyama
    Departments of Radiology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    JAMA 295:2483-91. 2006
  8. ncbi Stereotactic body radiation therapy: the report of AAPM Task Group 101
    Stanley H Benedict
    University of Virginia Health System, Charlottesville, Virginia 22908, USA
    Med Phys 37:4078-101. 2010
  9. ncbi Outcome in a prospective phase II trial of medically inoperable stage I non-small-cell lung cancer patients treated with stereotactic body radiotherapy
    Pia Baumann
    Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden
    J Clin Oncol 27:3290-6. 2009
  10. ncbi Stereotactic body radiotherapy (SBRT) for operable stage I non-small-cell lung cancer: can SBRT be comparable to surgery?
    Hiroshi Onishi
    Department of Radiology, School of Medicine, Yamanashi University, Yamanashi, Japan
    Int J Radiat Oncol Biol Phys 81:1352-8. 2011

Detail Information

Publications367 found, 100 shown here

  1. ncbi Hypofractionated stereotactic body radiotherapy in low-risk prostate adenocarcinoma: preliminary results of a multi-institutional phase 1 feasibility trial
    Sean M McBride
    Harvard Radiation Oncology Program, Harvard University, 100 Blossom Street, 3, Boston, MA 02114, USA
    Cancer 118:3681-90. 2012
    ..Here, the authors report on their own multi-institutional experience with extreme hypofractionated stereotactic radiotherapy for early stage disease...
  2. pmc Stereotactic body radiation therapy for inoperable early stage lung cancer
    Robert Timmerman
    Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    JAMA 303:1070-6. 2010
    ..Patients with early stage but medically inoperable lung cancer have a poor rate of primary tumor control (30%-40%) and a high rate of mortality (3-year survival, 20%-35%) with current management...
  3. ncbi Whole brain radiation therapy with or without stereotactic radiosurgery boost for patients with one to three brain metastases: phase III results of the RTOG 9508 randomised trial
    David W Andrews
    Department of Neurosurgery, Thomas Jefferson University Hospital, Philadelphia, PA 19107, USA
    Lancet 363:1665-72. 2004
    ..Brain metastases occur in up to 40% of all patients with systemic cancer. We aimed to assess whether stereotactic radiosurgery provided any therapeutic benefit in a randomised multi-institutional trial directed by the Radiation Therapy ..
  4. pmc Adjuvant whole-brain radiotherapy versus observation after radiosurgery or surgical resection of one to three cerebral metastases: results of the EORTC 22952-26001 study
    Martin Kocher
    University of Cologne, Cologne, Germany
    J Clin Oncol 29:134-41. 2011
    This European Organisation for Research and Treatment of Cancer phase III trial assesses whether adjuvant whole-brain radiotherapy (WBRT) increases the duration of functional independence after surgery or radiosurgery of brain metastases.
  5. ncbi Neurocognition in patients with brain metastases treated with radiosurgery or radiosurgery plus whole-brain irradiation: a randomised controlled trial
    Eric L Chang
    Department of Radiation Oncology, The University of Texas, M D Anderson Cancer Center, Houston, TX, USA
    Lancet Oncol 10:1037-44. 2009
    It is unclear whether the benefit of adding whole-brain radiation therapy (WBRT) to stereotactic radiosurgery (SRS) for the control of brain-tumours outweighs the potential neurocognitive risks...
  6. ncbi A European Organisation for Research and Treatment of Cancer phase III trial of adjuvant whole-brain radiotherapy versus observation in patients with one to three brain metastases from solid tumors after surgical resection or radiosurgery: quality-of-life
    Riccardo Soffietti
    University of Torino and San Giovanni Battista Hospital, Turin, Italy
    J Clin Oncol 31:65-72. 2013
    This phase III trial compared adjuvant whole-brain radiotherapy (WBRT) with observation after either surgery or radiosurgery of a limited number of brain metastases in patients with stable solid tumors...
  7. ncbi Stereotactic radiosurgery plus whole-brain radiation therapy vs stereotactic radiosurgery alone for treatment of brain metastases: a randomized controlled trial
    Hidefumi Aoyama
    Departments of Radiology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    JAMA 295:2483-91. 2006
    In patients with brain metastases, it is unclear whether adding up-front whole-brain radiation therapy (WBRT) to stereotactic radiosurgery (SRS) has beneficial effects on mortality or neurologic function compared with SRS alone.
  8. ncbi Stereotactic body radiation therapy: the report of AAPM Task Group 101
    Stanley H Benedict
    University of Virginia Health System, Charlottesville, Virginia 22908, USA
    Med Phys 37:4078-101. 2010
    ..Additionally, suggestions for developing consistent documentation for prescribing, reporting, and recording SBRT treatment delivery is provided...
  9. ncbi Outcome in a prospective phase II trial of medically inoperable stage I non-small-cell lung cancer patients treated with stereotactic body radiotherapy
    Pia Baumann
    Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden
    J Clin Oncol 27:3290-6. 2009
    ..The impact of stereotactic body radiotherapy (SBRT) on 3-year progression-free survival of medically inoperable patients with stage I non-small-cell lung cancer (NSCLC) was analyzed in a prospective phase II study...
  10. ncbi Stereotactic body radiotherapy (SBRT) for operable stage I non-small-cell lung cancer: can SBRT be comparable to surgery?
    Hiroshi Onishi
    Department of Radiology, School of Medicine, Yamanashi University, Yamanashi, Japan
    Int J Radiat Oncol Biol Phys 81:1352-8. 2011
    ..To review treatment outcomes for stereotactic body radiotherapy (SBRT) in medically operable patients with Stage I non-small-cell lung cancer (NSCLC), using a Japanese multi-institutional database...
  11. ncbi Long-term outcomes from a prospective trial of stereotactic body radiotherapy for low-risk prostate cancer
    Christopher R King
    Departments of Radiation Oncology, University of California Los Angeles School of Medicine, Los Angeles, CA 90095, USA
    Int J Radiat Oncol Biol Phys 82:877-82. 2012
    ..The results of a prospective trial of stereotactic body radiotherapy (SBRT) for prostate cancer with long-term patient-reported toxicity and tumor control rates are presented...
  12. pmc Stereotactic body radiotherapy for low-risk prostate cancer: five-year outcomes
    Debra E Freeman
    Naples Radiation Oncology, PA, USA
    Radiat Oncol 6:3. 2011
    ..Hypofractionated, stereotactic body radiotherapy (SBRT) is an emerging treatment approach for prostate cancer. We present the outcomes for low-risk prostate cancer patients with a median follow-up of 5 years after SBRT...
  13. ncbi Dose-escalation study of single-fraction stereotactic body radiotherapy for liver malignancies
    Karyn A Goodman
    Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Int J Radiat Oncol Biol Phys 78:486-93. 2010
    ..We performed a Phase I dose-escalation study to explore the feasibility and safety of treating primary and metastatic liver tumors with single-fraction stereotactic body radiotherapy (SBRT)...
  14. ncbi Multi-institutional phase I/II trial of stereotactic body radiation therapy for lung metastases
    Kyle E Rusthoven
    University of Colorado Denver, Department of Radiation Oncology and Medical Oncology, Aurora, CO 80045, USA
    J Clin Oncol 27:1579-84. 2009
    ..To evaluate the efficacy and tolerability of high-dose stereotactic body radiation therapy (SBRT) for the treatment of patients with one to three lung metastases...
  15. ncbi Phase I study of individualized stereotactic body radiotherapy for hepatocellular carcinoma and intrahepatic cholangiocarcinoma
    Regina V Tse
    Princess Margaret Hospital, University of Toronto, Toronto, Ontario, Canada
    J Clin Oncol 26:657-64. 2008
    ..To report outcomes of a phase I study of individualized stereotactic body radiotherapy treatment (SBRT) for unresectable hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (IHC)...
  16. ncbi Prognostic factors in stereotactic body radiotherapy for non-small-cell lung cancer
    Yukinori Matsuo
    Department of Radiation Oncology and Image Applied Therapy, Graduate School of Medicine, Kyoto University, Sakyo ku, Kyoto, Japan
    Int J Radiat Oncol Biol Phys 79:1104-11. 2011
    ..To investigate the factors that influence clinical outcomes after stereotactic body radiotherapy (SBRT) for non-small-cell lung cancer (NSCLC)...
  17. ncbi Geometrical differences in target volumes between slow CT and 4D CT imaging in stereotactic body radiotherapy for lung tumors in the upper and middle lobe
    Mitsuhiro Nakamura
    Department of Radiation Oncology and Image Applied Therapy, Graduate School of Medicine, Kyoto University, Kyoto 606 8507, Japan
    Med Phys 35:4142-8. 2008
    ..0, 5.4, 4.9, 5.1, 1.8, and 1.7 mm for lateral, medial, ventral, dorsal, cranial, and caudal directions, respectively...
  18. ncbi Stereotactic body radiotherapy using a radiobiology-based regimen for stage I nonsmall cell lung cancer: a multicenter study
    Yuta Shibamoto
    Department of Radiology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Cancer 118:2078-84. 2012
    ..5 cm, 1.5 to 3.0 cm, and >3.0 cm in greatest dimension, radiation doses of 44 Gy, 48 Gy, and 52 Gy, respectively, were given in 4 fractions with interfraction intervals of ≥3 days...
  19. ncbi Preliminary result of stereotactic body radiotherapy as a local salvage treatment for inoperable hepatocellular carcinoma
    Young Seok Seo
    Department of Radiation Oncology, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences, Nowon Gu, Seoul, Korea
    J Surg Oncol 102:209-14. 2010
    ..To evaluate the toxicity and efficacy of stereotactic body radiotherapy (SBRT) for the treatment of localized hepatocellular carcinoma (HCC) in the absence of another standard treatment option...
  20. ncbi Multi-institutional phase I/II trial of stereotactic body radiation therapy for liver metastases
    Kyle E Rusthoven
    University of Colorado Denver, Department of Radiation Oncology, Pathology, and Medical Oncology, Aurora, CO 80045, USA
    J Clin Oncol 27:1572-8. 2009
    ..To evaluate the efficacy and tolerability of high-dose stereotactic body radiation therapy (SBRT) for the treatment of patients with one to three hepatic metastases...
  21. ncbi Radiation therapy for hepatocellular carcinoma
    Mary Feng
    Department of Radiation Oncology, University of Michigan, Ann Arbor, MI, USA
    Semin Radiat Oncol 21:271-7. 2011
    ..These developments have led to a body of evidence that now supports the careful use of radiotherapy for unresectable HCC. The rationale for studying radiotherapy in a randomized trial is strong...
  22. ncbi Radiosurgery to the surgical cavity as adjuvant therapy for resected brain metastasis
    Jared R Robbins
    Department of Radiation Oncology, Henry Ford Hospital, Detroit, Michigan 48202, USA
    Neurosurgery 71:937-43. 2012
    The standard treatment of resected brain metastasis is whole-brain radiotherapy (WBRT). To avoid the potential toxicity of WBRT and to improve local control, we have used radiosurgery alone to the surgical cavity.
  23. ncbi Sequential phase I and II trials of stereotactic body radiotherapy for locally advanced hepatocellular carcinoma
    Alexis Bujold
    Princess Margaret Hospital, University Health Network, University of Toronto, Canada
    J Clin Oncol 31:1631-9. 2013
    ..To describe outcomes of prospective trials of stereotactic body radiotherapy (SBRT) for hepatocellular carcinoma (HCC)...
  24. pmc Intrafractional motion of the prostate during hypofractionated radiotherapy
    Yaoqin Xie
    Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305 5847, USA
    Int J Radiat Oncol Biol Phys 72:236-46. 2008
    ..To report the characteristics of prostate motion as tracked by the stereoscopic X-ray images of the implanted fiducials during hypofractionated radiotherapy with CyberKnife...
  25. pmc The role of stereotactic radiosurgery in the management of patients with newly diagnosed brain metastases: a systematic review and evidence-based clinical practice guideline
    Mark E Linskey
    Department of Neurosurgery, University of California Irvine Medical Center, Orange, CA, USA
    J Neurooncol 96:45-68. 2010
    Should patients with newly-diagnosed metastatic brain tumors undergo stereotactic radiosurgery (SRS) compared with other treatment modalities? Target population These recommendations apply to adults with newly diagnosed solid brain ..
  26. ncbi Outcomes and prognostic factors for patients with brainstem metastases undergoing stereotactic radiosurgery
    Mustafa Aziz Hatiboglu
    Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Neurosurgery 69:796-806; discussion 806. 2011
    Treatment of tumors metastatic to the brainstem with stereotactic radiosurgery (SRS) has not been widely studied.
  27. ncbi Systemic review of the patterns of failure following stereotactic body radiation therapy in early-stage non-small-cell lung cancer: clinical implications
    Alexander Chi
    Department of Radiation Oncology, University of Arizona, 1501 N Campbell Ave, Tucson, AZ 85724, USA
    Radiother Oncol 94:1-11. 2010
    ..To analyze the patterns of failure, the toxicity profile, and the factors influencing efficacy of stereotactic body radiation (SBRT) for early-stage non-small-cell lung cancer (NSCLC)...
  28. ncbi Stereotactic body radiation therapy for early-stage non-small-cell lung carcinoma: four-year results of a prospective phase II study
    Achilles J Fakiris
    Department of Radiation Oncology, Indiana University School of Medicine, 535 Barnhill Drive, Indianapolis, IN 46202, USA
    Int J Radiat Oncol Biol Phys 75:677-82. 2009
    ..The 50-month results of a prospective Phase II trial of stereotactic body radiation therapy (SBRT) in medically inoperable patients are reported...
  29. ncbi Malignant transformation of a vestibular schwannoma after gamma knife radiosurgery
    Masahiro Shin
    Department of Neurosurgery, University of Tokyo Hospital, Tokyo, Japan
    Lancet 360:309-10. 2002
    Stereotactic radiosurgery is used to treat benign tumours, but its long-term effects are not fully understood...
  30. ncbi Virtual HDR CyberKnife treatment for localized prostatic carcinoma: dosimetry comparison with HDR brachytherapy and preliminary clinical observations
    Donald B Fuller
    Radiosurgery Medical Group, Inc, San Diego CyberKnife Center, San Diego, CA 92123, USA
    Int J Radiat Oncol Biol Phys 70:1588-97. 2008
    ..We also report early clinical observations of CK SBRT treatment...
  31. ncbi The management of brain metastases
    Roy A Patchell
    Division of Neurosurgery, University of Kentucky Medical Center, Lexington, KY 40536, USA
    Cancer Treat Rev 29:533-40. 2003
    ..progress has been made in the treatment of these tumours, and radiotherapy, surgery, and stereotactic radiosurgery are now established treatments...
  32. ncbi Phase I feasibility trial of stereotactic body radiation therapy for primary hepatocellular carcinoma
    Higinia R Cardenes
    Department of Radiation Oncology, Indiana University School of Medicine, Indianapolis 46202, USA
    Clin Transl Oncol 12:218-25. 2010
    ..Hepatocellular carcinoma (HCC) is increasing in incidence and the majority of patients are not candidates for radical therapies. Therefore, interest in minimally invasive therapies in growing...
  33. pmc Stereotactic body radiotherapy for organ-confined prostate cancer
    Alan J Katz
    Winthrop University Hospital, 264 Old Country Road, Mineola, NY 11501, USA
    BMC Urol 10:1. 2010
    ..We present preliminary results following stereotactic body radiotherapy (SBRT) treatment for organ-confined prostate cancer...
  34. ncbi Management of cerebral metastasis: evidence-based approach for surgery, stereotactic radiosurgery and radiotherapy
    Michael D Jenkinson
    Department of Neurosurgery, The Walton Centre for Neurology and Neurosurgery, Lower Lane, Liverpool, L9 7LJ, UK
    Eur J Cancer 47:649-55. 2011
    ..This review discusses the relative merits of open surgery, whole brain radiotherapy (WBRT) and stereotactic radiosurgery (SRS), which have been used alone and in combination with varying degrees of success for the treatment of newly ..
  35. ncbi Sexual function after stereotactic body radiotherapy for prostate cancer: results of a prospective clinical trial
    Ellen A Wiegner
    Department of Radiation Oncology, Stanford University School of Medicine, CA, USA
    Int J Radiat Oncol Biol Phys 78:442-8. 2010
    ..To study the sexual quality of life for prostate cancer patients after stereotactic body radiotherapy (SBRT)...
  36. ncbi Salvage stereotactic reirradiation with or without cetuximab for locally recurrent head-and-neck cancer: a feasibility study
    Bénédicte Comet
    Department of Academic Radiotherapy, Centre Oscar Lambret and University Lille II, Lille, France
    Int J Radiat Oncol Biol Phys 84:203-9. 2012
    ..Stereotactic body radiotherapy (SBRT) could offer precise irradiation while sparing healthy tissues. Results of a feasibility study using SBRT with or without cetuximab are reported for reirradiation of recurrent primary HNC...
  37. ncbi Single dose radiosurgical treatment of recurrent previously irradiated primary brain tumors and brain metastases: final report of RTOG protocol 90-05
    E Shaw
    Department of Radiation Oncology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1030, USA
    Int J Radiat Oncol Biol Phys 47:291-8. 2000
    To determine the maximum tolerated dose of single fraction radiosurgery in patients with recurrent previously irradiated primary brain tumors and brain metastases.
  38. ncbi Stereotactic body radiotherapy for oligometastatic lung tumors
    Yoshiki Norihisa
    Department of Radiation Oncology and Image Applied Therapy, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Int J Radiat Oncol Biol Phys 72:398-403. 2008
    ..The term "oligometastasis" is used to indicate a small number of metastases limited to an organ. We evaluated our clinical experience of SBRT for oligometastatic lung tumors...
  39. ncbi A pathology-based substrate for target definition in radiosurgery of brain metastases
    Brigitta G Baumert
    Department of Radiation Oncology MAASTRO, GROW, University Hospital Maastricht, Maastricht, The Netherlands
    Int J Radiat Oncol Biol Phys 66:187-94. 2006
    To investigate the need of a margin other than for accuracy reasons in stereotactic radiosurgery (SRS) of brain metastases by means of histopathology.
  40. pmc Radiation dose-volume effects in the brain
    Yaacov Richard Lawrence
    Department of Radiation Oncology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Int J Radiat Oncol Biol Phys 76:S20-7. 2010
    ..5 Gy), the incidence and severity of toxicity is unpredictable. For single fraction radiosurgery, a clear correlation has been demonstrated between the target size and the risk of adverse events...
  41. ncbi Factors important for efficacy of stereotactic body radiotherapy of medically inoperable stage I lung cancer. A retrospective analysis of patients treated in the Nordic countries
    Pia Baumann
    Division of Oncology and Hospital Physics, Radiumhemmet Karolinska University Hospital, Sweden
    Acta Oncol 45:787-95. 2006
    ..EQD2 (> v.s.<55.6 Gy) showed a statistically significant benefit survival for the higher doses. SBRT for stage I NSCLC results in favourable local control not inferior to fractionated RT and with acceptable toxicity...
  42. ncbi Clinical outcomes of stereotactic radiosurgery in the treatment of patients with metastatic brain tumors
    Ameer L Elaimy
    Gamma Knife of Spokane, Spokane, Washington, USA
    World Neurosurg 75:673-83. 2011
    Stereotactic radiosurgery (SRS) is a form of radiation therapy that delivers a focused, highly conformal dose of radiation to a single volume, while minimizing damage to the adjacent nervous tissue...
  43. ncbi Treatment of spinal tumors using cyberknife fractionated stereotactic radiosurgery: pain and quality-of-life assessment after treatment in 200 patients
    Gregory J Gagnon
    Department of Radiation Medicine, Georgetown University Hospital, Washington, District of Columbia, USA
    Neurosurgery 64:297-306; discussion 306-7. 2009
    ..Image-guided stereotactic radiosurgery using the CyberKnife system (Accuray, Inc...
  44. ncbi Radiotherapy and radiosurgery for metastatic spine disease: what are the options, indications, and outcomes?
    Peter C Gerszten
    Department of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Spine (Phila Pa 1976) 34:S78-92. 2009
    ..Systematic literature review...
  45. ncbi Stereotactic body radiation therapy for lung metastases
    Umberto Ricardi
    Radiation Oncology Department, University Hospital S Giovanni Battista di Torino, Via Genova 3, 10126, Torino, Italy
    Lung Cancer 75:77-81. 2012
    ..Purpose of this study was to evaluate efficacy and tolerability of SBRT in a cohort of patients treated between 2003 and 2009 at our institution...
  46. pmc Phase I dose-escalation study of stereotactic body radiation therapy for low- and intermediate-risk prostate cancer
    Thomas P Boike
    University of Texas Southwestern, Dallas, TX 75390, USA
    J Clin Oncol 29:2020-6. 2011
    ..To evaluate the tolerability of escalating doses of stereotactic body radiation therapy in the treatment of localized prostate cancer...
  47. ncbi Malignancy in a vestibular schwannoma. Report of a case with central neurofibromatosis, treated by both stereotactic radiosurgery and surgical excision, with a review of the literature
    M E Bari
    Department of Neurosurgery, Royal Hallamshire Hospital, Sheffield, UK
    Br J Neurosurg 16:284-9. 2002
    ..This paper presents a case of rapidly growing vestibular schwannoma first treated by radiosurgery whose histopathology after surgical excision 42 months later showed malignant changes...
  48. ncbi The CyberKnife Robotic Radiosurgery System in 2010
    W Kilby
    Accuray Incorporated, 1310 Chesapeake Terrace, Sunnyvale, CA 94089, USA
    Technol Cancer Res Treat 9:433-52. 2010
    ..Finally, the relationship between technical developments and the greatly increased range of clinical applications they have allowed is reviewed briefly...
  49. ncbi Hypofractionated stereotactic radiotherapy alone without whole-brain irradiation for patients with solitary and oligo brain metastasis using noninvasive fixation of the skull
    Hidefumi Aoyama
    Department of Radiology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Int J Radiat Oncol Biol Phys 56:793-800. 2003
    ..and toxicity of hypofractionated stereotactic radiotherapy (HSRT) using noninvasive fixation of the skull on solitary or oligo brain metastatic patients as an alternative to stereotactic radiosurgery (SRS) using invasive fixation.
  50. ncbi Extracranial stereotactic radioablation: results of a phase I study in medically inoperable stage I non-small cell lung cancer
    Robert Timmerman
    Department of Radiation Oncology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Chest 124:1946-55. 2003
    ..We set out to investigate a new therapy akin to brain radiosurgery called extracranial stereotactic radioablation (ESR) in a phase I trial.
  51. ncbi Radiosurgery for brain metastases: a score index for predicting prognosis
    E Weltman
    Department of Radiation Oncology, Hospital Israelita Albert Einstein, Sao Paulo, Brazil
    Int J Radiat Oncol Biol Phys 46:1155-61. 2000
    To analyze a prognostic score index for patients with brain metastases submitted to stereotactic radiosurgery (the Score Index for Radiosurgery in Brain Metastases [SIR]).
  52. pmc Long-term effect of stereotactic body radiation therapy for primary hepatocellular carcinoma ineligible for local ablation therapy or surgical resection. Stereotactic radiotherapy for liver cancer
    Jung Hyun Kwon
    Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea
    BMC Cancer 10:475. 2010
    ..We evaluated the long-term effect of stereotactic body radiation therapy (SBRT) for primary small hepatocellular carcinoma (HCC) ineligible for local therapy or surgery...
  53. ncbi A phase II study on stereotactic body radiotherapy for stage I non-small cell lung cancer
    Masashi Koto
    Department of Radiation Oncology, Tohoku University Graduate School of Medicine, 1 1 Seiryo machi, Aobaku, Sendai, Japan
    Radiother Oncol 85:429-34. 2007
    ..We aimed to evaluate the clinical outcome of stereotactic body radiotherapy (SBRT) in the treatment of stage I NSCLC...
  54. ncbi Phase I study of individualized stereotactic body radiotherapy of liver metastases
    Mark T Lee
    Radiation Medicine Program, Department of Biostatistics and Medical Oncology, Princess Margaret Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada
    J Clin Oncol 27:1585-91. 2009
    ..To report on the outcomes of a phase I study of stereotactic body radiotherapy (SBRT) for treatment of liver metastases...
  55. ncbi Stereotactic imaging for radiosurgery: localization accuracy of magnetic resonance imaging and positron emission tomography compared with computed tomography
    Yoshimasa Mori
    Nagoya Radiosurgery Center, Nagoya Kyoritsu Hospital, Nagoya, Japan
    Stereotact Funct Neurosurg 84:142-6. 2006
    ..and positron emission tomography (PET) provide complementary information for treatment planning in stereotactic radiosurgery. We evaluated the localization accuracy of MRI and PET compared with CT...
  56. ncbi Stereotactic body radiotherapy for primary hepatocellular carcinoma
    David L Andolino
    Department of Radiation Oncology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Int J Radiat Oncol Biol Phys 81:e447-53. 2011
    ..To evaluate the safety and efficacy of stereotactic body radiotherapy (SBRT) for the treatment of primary hepatocellular carcinoma (HCC)...
  57. ncbi Stereotactic body radiation therapy in recurrent hepatocellular carcinoma
    Wen Yen Huang
    Department of Radiation Oncology, Tri Service General Hospital, National Defense Medical Center, Taipei, Taiwan, ROC
    Int J Radiat Oncol Biol Phys 84:355-61. 2012
    ..To examine the safety and efficacy of Cyberknife stereotactic body radiation therapy (SBRT) and its effect on survival in patients of recurrent hepatocellular carcinoma (HCC)...
  58. ncbi Radiographic changes after lung stereotactic ablative radiotherapy (SABR)--can we distinguish recurrence from fibrosis? A systematic review of the literature
    Kitty Huang
    Department of Radiation Oncology, London Health Sciences Centre, University of Western Ontario, London, Canada
    Radiother Oncol 102:335-42. 2012
    ..We performed a systematic review to describe post-SABR findings on computed tomography (CT) and positron-emission tomography (PET), identify imaging characteristics that predict recurrence and propose a follow-up imaging algorithm...
  59. ncbi Stereotactic body radiotherapy for colorectal liver metastases: a pooled analysis
    Daniel T Chang
    Department of Radiation Oncology, Stanford University, Stanford, California, USA
    Cancer 117:4060-9. 2011
    ..This study was undertaken to determine outcomes of stereotactic body radiotherapy for colorectal liver metastases in a pooled patient cohort...
  60. ncbi Treatment of five or more brain metastases with stereotactic radiosurgery
    Grant K Hunter
    Department of Radiation Oncology, Cleveland Clinic, Cleveland, OH, USA
    Int J Radiat Oncol Biol Phys 83:1394-8. 2012
    To examine the outcomes of patients with five or more brain metastases treated in a single session with stereotactic radiosurgery (SRS).
  61. ncbi Development of a model to predict permanent symptomatic postradiosurgery injury for arteriovenous malformation patients. Arteriovenous Malformation Radiosurgery Study Group
    J C Flickinger
    Department of Radiation Oncology, University of Pittsburgh School of Medicine, PA, USA
    Int J Radiat Oncol Biol Phys 46:1143-8. 2000
    To better predict permanent complications from arteriovenous malformation (AVM) radiosurgery.
  62. ncbi Stereotactic radiotherapy of histologically proven inoperable stage I non-small cell lung cancer: patterns of failure
    Nicolaus Andratschke
    Klinik und Poliklinik für Strahlentherapie und Radiologische Onkologie, Klinikum rechts der Isar, Technische Universitat Munchen, Ismaninger Strasse 22, Munich, Germany
    Radiother Oncol 101:245-9. 2011
    ..To report patterns of failure of stereotactic body radiation therapy (SBRT) in inoperable patients with histologically confirmed stage I NSCLC...
  63. ncbi Spinal cord tolerance for stereotactic body radiotherapy
    Arjun Sahgal
    Department of Radiation Oncology, Sunnybrook Health Sciences Centre, Princess Margaret Hospital, University of Toronto, Toronto, Ontario, Canada
    Int J Radiat Oncol Biol Phys 77:548-53. 2010
    ..Dosimetric data are reported for five cases of radiation-induced myelopathy after stereotactic body radiotherapy (SBRT) to spinal tumors. Analysis per the biologically effective dose (BED) model was performed...
  64. ncbi Comparative risk of leptomeningeal dissemination of cancer after surgery or stereotactic radiosurgery for a single supratentorial solid tumor metastasis
    Dima Suki
    Department of Neurosurgery, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Neurosurgery 64:664-74; discussion 674-6. 2009
    ..hypothesis that differential risks of developing leptomeningeal disease (LMD) exist in patients having a single supratentorial brain metastasis resected via a piecemeal or en bloc approach or treated with stereotactic radiosurgery (SRS).
  65. pmc A survey of stereotactic body radiotherapy use in the United States
    Hubert Pan
    Department of Radiation Oncology, Center for Advanced Radiotherapy Technologies, University of California at San Diego, La Jolla, California, USA
    Cancer 117:4566-72. 2011
    ..To the authors' knowledge, the prevalence of SBRT use among radiation oncologists in the United States is unknown...
  66. ncbi Phase I dose-escalation study of stereotactic body radiotherapy in patients with hepatic metastases
    William Rule
    Department of Radiation Oncology, University of Texas Southwestern, 5801 Forest Park Road, Dallas, TX, USA
    Ann Surg Oncol 18:1081-7. 2011
    ..To identify a tolerable and effective dose for 5-fraction stereotactic body radiotherapy for hepatic metastases...
  67. ncbi Analysis of radiosurgical results in patients with brain metastases according to the number of brain lesions: is stereotactic radiosurgery effective for multiple brain metastases?
    Won Seok Chang
    Department of Neurosurgery, Gamma Knife Center and Brain Research Institute, Yonsei University College of Medicine, Seoul, Republic of Korea
    J Neurosurg 113:73-8. 2010
    Whole-brain radiation therapy (WBRT), open resection, and stereotactic radiosurgery (SRS) are widely used for treatment of metastatic brain lesions, and many physicians recommend WBRT for multiple brain metastases...
  68. ncbi Observation of a dose-control relationship for lung and liver tumors after stereotactic body radiation therapy
    Robert McCammon
    Department of Radiation Oncology, University of Colorado Health Sciences Center, Aurora, CO, USA
    Int J Radiat Oncol Biol Phys 73:112-8. 2009
    ..To determine prognostic factors for local control of primary or metastatic tumors within the lung or liver treated with stereotactic body radiation therapy (SBRT) within a single institution...
  69. ncbi Comparison of stereotactic brachytherapy (125 iodine seeds) with stereotactic radiosurgery (LINAC) for the treatment of singular cerebral metastases
    Maximilian I Ruge
    Department of Stereotactic and Functional Neurosurgery, University of Cologne, Cologne, Germany
    Strahlenther Onkol 187:7-14. 2011
    To compare stereotactic brachytherapy (SBT) with stereotactic radiosurgery (SRS) for treating singular cerebral metastases, regarding feasibility, complications, cerebral disease control, and survival.
  70. ncbi Radiobiological evaluation of the radiation dose as used in high-precision radiotherapy: effect of prolonged delivery time and applicability of the linear-quadratic model
    Yuta Shibamoto
    Department of Radiology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    J Radiat Res 53:1-9. 2012
    ..Another issue related to radiosurgery and hypofractionated stereotactic radiotherapy is the mathematical model for dose evaluation and conversion...
  71. ncbi Phase II study on stereotactic body radiotherapy of colorectal metastases
    Morten Hoyer
    Department of Oncology, Aarhus University Hospital
    Acta Oncol 45:823-30. 2006
    ..One toxic death and few severe reactions were observed. For the majority of patients, the treatment related toxicity was moderate...
  72. ncbi Stereotactic high dose fraction radiation therapy of extracranial tumors using an accelerator. Clinical experience of the first thirty-one patients
    H Blomgren
    Department of Oncology, Karolinska Hospital, Stockholm, Sweden
    Acta Oncol 34:861-70. 1995
    ..We observed a local rate of no progressive disease of 80% during a follow-up period of 1.5-38 months. Fifty percent of the tumors decreased in size or disappeared...
  73. ncbi Clinical outcomes of stereotactic radiotherapy for stage I non-small cell lung cancer using a novel irradiation technique: patient self-controlled breath-hold and beam switching using a combination of linear accelerator and CT scanner
    Hiroshi Onishi
    Department of Radiation Oncology, Yamanashi Medical University, 1110 Shimokato Tamaho Cho, Nakakoma gun, Yamanashi 409 3898, Japan
    Lung Cancer 45:45-55. 2004
    ..Based on the initial results, excellent local control with minimal complications is expected for stage I NSCLC...
  74. ncbi Stereotactic body radiation therapy for primary and metastatic liver tumors: A single institution phase i-ii study
    Alejandra Méndez Romero
    Department of Radiation Oncology, Erasmus MC Daniel den Hoed Cancer Center, Rotterdam, The Netherlands
    Acta Oncol 45:831-7. 2006
    ..Optimal dose-fractionation schemes for HCC with cirrhosis have to be found. Extreme caution should be used for patients with Child B because of a high toxicity risk...
  75. ncbi Radiosurgery for patients with brain metastases: a multi-institutional analysis, stratified by the RTOG recursive partitioning analysis method
    S N Sanghavi
    University of Wisconsin, Madison, WI 53792, USA
    Int J Radiat Oncol Biol Phys 51:426-34. 2001
    ..by the Radiation Therapy Oncology Group (RTOG) recursive partitioning analysis (RPA) class and treated with radiosurgery (RS) plus whole brain radiotherapy (WBRT)...
  76. ncbi Acute toxicity after cyberknife-delivered hypofractionated radiotherapy for treatment of prostate cancer
    Natasa C Townsend
    Department of Radiation Oncology, Drexel University College of Medicine, Philadelphia, PA 19102, USA
    Am J Clin Oncol 34:6-10. 2011
    ..To evaluate acute toxicity outcomes of prostate cancer patients treated with CyberKnife-delivered hypofractionated radiotherapy...
  77. ncbi Extending the linear-quadratic model for large fraction doses pertinent to stereotactic radiotherapy
    M Guerrero
    Department of Radiation Oncology, University of Maryland, Baltimore, MD 21201, USA
    Phys Med Biol 49:4825-35. 2004
    Ongoing clinical trials designed to explore the use of extracranial stereotactic radiosurgery (ESR) for different tumour sites use large doses per fraction (15, 20, 30 Gy or even larger)...
  78. ncbi Radiosurgery with or without whole-brain radiotherapy for brain metastases: the patients' perspective regarding complications
    Douglas Kondziolka
    Department of Neurological Surgery and Radiation Oncology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Am J Clin Oncol 28:173-9. 2005
    ..Whole-brain radiation therapy (WBRT) and/or radiosurgery (RS) are mainstays of management for patients with metastatic brain cancer...
  79. ncbi Gamma Knife radiosurgery as a primary surgical treatment for hypersecreting pituitary adenomas
    N Zhang
    Department of Neurosurgery, Hua Shan Hospital and Shanghai Gamma Knife Hospital, Shanghai, China
    Stereotact Funct Neurosurg 75:123-8. 2000
    To estimate the efficacy of Gamma Knife radiosurgery (GKR) especially as a primary surgical treatment for hypersecreting pituitary adenomas.
  80. ncbi Surgery and radiotherapy compared with gamma knife radiosurgery in the treatment of solitary cerebral metastases of small diameter
    A Muacevic
    Department of Neurosurgery, Ludwig Maximilians University, Klinikum Grosshadern, and Gamma Knife Center, Munich, Germany
    J Neurosurg 91:35-43. 1999
    ..retrospective study was to compare treatment results of surgery plus whole-brain radiation therapy (WBRT) with gamma knife radiosurgery alone as the primary treatment for solitary cerebral metastases suitable for radiosurgical treatment.
  81. ncbi Phase I/II study of stereotactic body radiotherapy for spinal metastasis and its pattern of failure
    Eric L Chang
    Departments of Radiation Oncology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Neurosurg Spine 7:151-60. 2007
    ..The authors report data concerning the safety, effectiveness, and patterns of failure obtained in a Phase I/II study of stereotactic body radiotherapy (SBRT) for spinal metastatic tumors...
  82. ncbi Radiosurgery for treatment of brain metastases: estimation of patient eligibility using three stratification systems
    Jose Lorenzoni
    Gamma Knife Center and Department of Neurosurgery, Hopital Erasme, Route de Lennik 808, Brussels B 1070, Belgium
    Int J Radiat Oncol Biol Phys 60:218-24. 2004
    To compare three patient stratification systems predicting survival: recursive partitioning analysis (RPA), score index for radiosurgery in brain metastases (SIR), and a proposed basic score for brain metastases (BS-BM).
  83. ncbi Stereotactic radiotherapy of primary lung cancer and other targets: results of consultant meeting of the International Atomic Energy Agency
    Yasushi Nagata
    Hiroshima University Hospital, Department of Radiation Oncology, Hiroshima, Japan
    Int J Radiat Oncol Biol Phys 79:660-9. 2011
    ..Despite the disadvantages expected to be experienced in developing countries, SBRT using fewer fractions may be useful in selected patients with various extracranial cancers with favorable outcome and low toxicity...
  84. ncbi Radiation pneumonitis in patients treated for malignant pulmonary lesions with hypofractionated radiation therapy
    Gerben R Borst
    Department of Radiation Oncology, Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands
    Radiother Oncol 91:307-13. 2009
    ..We evaluated the relationship between the mean lung dose (MLD) and the incidence of radiation pneumonitis (RP) after stereotactic body radiation therapy (SBRT), and compared this with conventional fractionated radiation therapy (CFRT)...
  85. ncbi Universal survival curve and single fraction equivalent dose: useful tools in understanding potency of ablative radiotherapy
    Clint Park
    Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9183, USA
    Int J Radiat Oncol Biol Phys 70:847-52. 2008
    ....
  86. pmc Stereotactic radiosurgery for brain metastases: analysis of outcome and risk of brain radionecrosis
    Giuseppe Minniti
    Department of Radiation Oncology, Sant Andrea Hospital, University La Sapienza, Rome, Italy
    Radiat Oncol 6:48. 2011
    to investigate the factors affecting survival and toxicity in patients treated with stereotactic radiosurgery (SRS), with special attention to volumes of brain receiving a specific dose (V10 - V16 Gy) as predictors for brain radionecrosis.
  87. ncbi Palliative radiotherapy for bone metastases: an ASTRO evidence-based guideline
    Stephen Lutz
    Department of Radiation Oncology, Blanchard Valley Regional Cancer Center, Findlay, OH 45840, USA
    Int J Radiat Oncol Biol Phys 79:965-76. 2011
    ..To present guidance for patients and physicians regarding the use of radiotherapy in the treatment of bone metastases according to current published evidence and complemented by expert opinion...
  88. ncbi Microsurgery plus whole brain irradiation versus Gamma Knife surgery alone for treatment of single metastases to the brain: a randomized controlled multicentre phase III trial
    Alexander Muacevic
    Department of Neurosurgery, Ludwig Maximilians University, Klinikum Grosshadern, Munich 81377, Germany
    J Neurooncol 87:299-307. 2008
    ..Is Gamma Knife surgery alone as effective as surgery plus whole brain irradiation (WBRT) for patients with a single, small-sized brain metastasis?..
  89. ncbi Gamma knife stereotactic radiosurgery for acromegaly
    Einar Osland Vik-Mo
    Department of Neurosurgery, Haukeland University Hospital, Bergen, Norway
    Eur J Endocrinol 157:255-63. 2007
    Gamma knife radiosurgery (GKR) is an adjuvant treatment for acromegaly if surgery fails to normalize GH hypersecretion.
  90. ncbi Radiosurgery for spinal metastases: clinical experience in 500 cases from a single institution
    Peter C Gerszten
    Department of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Spine (Phila Pa 1976) 32:193-9. 2007
    ..A prospective nonrandomized, longitudinal cohort study...
  91. ncbi A rationale for the targeted treatment of oligometastases with radiotherapy
    Dhara M Macdermed
    Department of Radiation and Cellular Oncology, University of Chicago, Chicago, Illinois 60637, USA
    J Surg Oncol 98:202-6. 2008
    ....
  92. ncbi Radiosurgery of growth hormone-producing pituitary adenomas: factors associated with biochemical remission
    Bruce E Pollock
    Department of Neurological Surgery, Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Neurosurg 106:833-8. 2007
    The authors reviewed outcomes after stereotactic radiosurgery for patients with acromegaly and analyzed factors associated with biochemical remission.
  93. pmc Stereotactic body radiation therapy with or without transarterial chemoembolization for patients with primary hepatocellular carcinoma: preliminary analysis
    Byung Ock Choi
    Department of Radiation Oncology, The Catholic University of Korea, School of Medicine, Seoul, South Korea
    BMC Cancer 8:351. 2008
    ....
  94. ncbi The American Society for Therapeutic Radiology and Oncology (ASTRO) evidence-based review of the role of radiosurgery for brain metastases
    Minesh P Mehta
    The American Society for Therapeutic Radiology and Oncology, Fairfax, VA 22033, USA
    Int J Radiat Oncol Biol Phys 63:37-46. 2005
    To systematically review the evidence for the use of stereotactic radiosurgery in adult patients with brain metastases.
  95. ncbi Gamma knife radiosurgery for acromegaly--long-term experience
    Jana Jezkova
    Third Department of Medicine, First Medical Faculty, Charles University, Prague, Czech Republic
    Clin Endocrinol (Oxf) 64:588-95. 2006
    ..The Leksell gamma knife (LGK) is one of the treatment options for pituitary adenomas. We report on our long-term experience treating acromegaly using LGK...
  96. ncbi Stereotactic body radiotherapy for localized prostate cancer: interim results of a prospective phase II clinical trial
    Christopher R King
    Department of Radiation Oncology, Division of Urologic Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Int J Radiat Oncol Biol Phys 73:1043-8. 2009
    ..The radiobiology of prostate cancer favors a hypofractionated dose regimen. We report results of a prospective Phase II clinical trial of stereotactic body radiotherapy (SBRT) for localized prostate cancer...
  97. ncbi Stereotactic 125iodine brachytherapy for the treatment of singular brain metastases: closing a gap?
    Maximilian I Ruge
    Department of Stereotactic and Functional Neurosurgery, Albertus Magnus University of Cologne, Otto v Guericke University, Magdeburg, Germany
    Neurosurgery 68:1209-18; discussion 1218-9. 2011
    ..Brain metastases represent the most common intracranial tumors and are associated with very poor prognosis...
  98. ncbi A comparison of surgical resection and stereotactic radiosurgery in the treatment of solitary brain metastases
    BRIAN PATRICK O'NEILL
    Department of Neurology, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Int J Radiat Oncol Biol Phys 55:1169-76. 2003
    To determine whether neurosurgery (NS) or stereotactic radiosurgery (RS) provided better local tumor control and enhanced patient survival.
  99. ncbi A dosimetric model of duodenal toxicity after stereotactic body radiotherapy for pancreatic cancer
    James D Murphy
    Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305 5152, USA
    Int J Radiat Oncol Biol Phys 78:1420-6. 2010
    ..The duodenum is generally considered to be the organ at greatest risk. This study reports on the dosimetric determinants of duodenal toxicity with single-fraction SBRT...
  100. ncbi Stereotactic body radiotherapy for medically inoperable lung cancer: prospective, single-center study of 108 consecutive patients
    Mojgan Taremi
    Radiation Medicine Program, Princess Margaret Hospital, Toronto, ON, Canada
    Int J Radiat Oncol Biol Phys 82:967-73. 2012
    ..To present the results of stereotactic body radiotherapy (SBRT) for medically inoperable patients with Stage I non-small-cell lung cancer (NSCLC) and contrast outcomes in patients with and without a pathologic diagnosis...
  101. ncbi Stereotactic body radiotherapy for multisite extracranial oligometastases: final report of a dose escalation trial in patients with 1 to 5 sites of metastatic disease
    Joseph K Salama
    Department of Radiation Oncology, Duke University, Durham, North Carolina 27710, USA
    Cancer 118:2962-70. 2012
    ..A subset of patients with metastatic cancer in limited organs may benefit from metastasis-directed therapy. The authors investigated whether patients with limited metastases could be safely treated with metastasis-directed radiotherapy...

Research Grants63

  1. Contribution of c-Jun N-terminal kinase activity to vestibular schwannoma growth
    Marlan R Hansen; Fiscal Year: 2013
    ..Microsurgical removal and stereotactic radiosurgery/stereotactic radiotherapy (SRS/SRT) constitute the only current treatments for VSs and often result in deafness,..
  2. Endothelial Progenitor Cells in Brain Arteriovenous Malformations
    Yongmei Chen; Fiscal Year: 2010
    ..The two study cohorts will be age and gender matched. Patients with embolization, radiosurgery, and hemorrhage will be excluded to avoid possible confounding effects...
  3. Cath B and uPAR si RNA constructs regressed glioma growth
    JOHN P O'BRYAN; Fiscal Year: 2013
    ..concern about radiation-related side effects that may occur even with highly accurate therapies such as radiosurgery. Despite some therapeutic effect, recent evidence has shown that irradiation may promote malignant behaviors of ..
  4. Radiosurgery vs lobectomy for temporal lobe epilepsy: Phase 3 Clinical Trial
    Nicholas M Barbaro; Fiscal Year: 2012
    ..excess of 80% and with acceptable toxicity, there is equipoise for treating well-selected patients with either radiosurgery or temporal resection...
  5. Combination therapy to inhibit neuroblastoma growth
    CHRISTOPHER SUMEET BABU GONDI; Fiscal Year: 2013
    ..concern about radiation-related side effects that may occur even with highly accurate therapies such as radiosurgery. Despite some therapeutic effect, recent evidence has shown that irradiation may promote malignant behaviors of ..
  6. PREDICTORS OF SPONTANEOUS CEREBRAL AVM HEMORRHAGE
    Helen Kim; Fiscal Year: 2013
    ..Trial of Unruptured Brain AVMs (ARUBA), is comparing best intervention (either surgery, embolization and/or radiosurgery) vs. non-intervention...
  7. Nanoparticle-Directed Photothermal Ablation of Primary Brain Tumors guided by Mag
    R Jason Stafford; Fiscal Year: 2012
    ..accepted treatment modalities for tumors of the brain include surgery, whole-brain radiotherapy, stereotactic radiosurgery, chemotherapy;or some combination of these, but these treatments are by no means curative for most patients and ..
  8. Radiation-Induced Cardiopulmonary Injury in Humans
    Lawrence B Marks; Fiscal Year: 2012
    ..Further, new conformal RT methods (e.g., intensity modulated RT, radiosurgery), often expose large portions of the lung and heart to diverse RT doses and fraction sizes...
  9. Combination therapy to inhibit glioma growth by Ad MMP2 and radiation
    Jasti S Rao; Fiscal Year: 2012
    ..concern about radiation-related side effects that may occur even with highly accurate therapies such as radiosurgery. Despite some therapeutic effect, recent evidence has shown that irradiation may promote malignant behaviors of ..
  10. Regression of meningioma tumor growth by combination therapy
    Jasti S Rao; Fiscal Year: 2012
    ..concern about radiation- related side effects that may occur even with highly accurate therapies such as radiosurgery. Besides therapeutic effect, recent evidence has shown that irradiation may promote malignant behaviors of ..
  11. 18F-Fluorocholine to distinguish necrosis from recurrence in brain metastases
    John L Humm; Fiscal Year: 2013
    ..Stereotactic radiosurgery (SRS) is a common treatment for patients with a limited number of brain metastases...
  12. Design of a real-time dosimetry prototype for use with external beam radiotherapy
    ENRIQUE WILMAR IZAGUIRRE; Fiscal Year: 2013
    ..treatments such as intensity modulated radiation therapy (IMRT), volumetric modulated arc therapy, stereotactic radiosurgery and stereotactic body radiation therapy using clinical linear accelerators...
  13. Image-Guided Stereotactic Radiosurgery of Breast Cancer
    CEDRIC XINSHENG YU; Fiscal Year: 2010
    ..and the treatment couch for delivering breast SRS;2) Develop the treatment planning system (TPS) for gamma radiosurgery of breast cancer;3) Perform system integration and radiation testing to verify geometric and dosimetric ..
  14. A Randomized Trial of Unruptured Brain Arteriovenous Malformations (ARUBA)
    Jay P Mohr; Fiscal Year: 2013
    ..Patients will be randomized to medical management or to invasive treatment (endovascular, neurosurgical, or radiosurgery, alone or in combination) and followed for a minimum of 5 years...
  15. A Randomized Trial of Unruptured Brain AVMs (ARUBA)-STAT
    Alan J Moskowitz; Fiscal Year: 2013
    ..Patients will be randomized to medical management or invasive therapy (endovascular, neurosurgical, or radiosurgery, alone or in combination) and followed for a minimum of 5 years...
  16. COMMUNITY CLINICAL ONCOLOGY PROGRAM
    Deborah Watkins Bruner; Fiscal Year: 2013
    ..of different fractionation schedules for the palliation of painful bone metastases, the use of stereotactic radiosurgery to palliate spinal metastases, and the use of hippocampal avoidance with RT treatment planning to minimize ..
  17. MRI-guided focused ultrasound for drug delivery and ablation of brain tumors
    Nathan J McDannold; Fiscal Year: 2013
    ..combine FUS and a microbubble agent to enable non-thermal ablation, a noninvasive alternative to surgery and radiosurgery. With this method, we can ablate tissue volumes practically anywhere in the brain without using ionizing ..
  18. MR-Guided Precision Conformal Ablation Therapy for Brain Tumors
    JULIE GEORGIA PILITSIS; Fiscal Year: 2013
    ..Treatment of BMs is often multidisciplinary involving open surgery, stereotactic radiosurgery (SRS), whole brain radiation, and/or chemotherapy...
  19. Water-Equivalent Plastic Scintillation Detectors for Small-Field Radiotherapy
    DANIEL G SCHMIDT; Fiscal Year: 2010
    ..radiation dosimeters for small field dosimetry, which are needed in clinical applications such as stereotactic radiosurgery/ stereotactic radiotherapy (SRS/SRT), intensity modulated radiation therapy (IMRT), dynamical arc therapy and ..
  20. Water-Equivalent Plastic Scintillation Detectors for Small-Field Radiotherapy
    DANIEL G SCHMIDT; Fiscal Year: 2013
    ..These small detectors are needed in clinical applications such as stereotactic radiosurgery/stereotactic radiotherapy (SRS/SRT), intensity modulated radiation therapy (IMRT), dynamic arc therapy, and ..
  21. RADIOSURGICAL TREATMENT OF TEMPORAL LOBE EPILEPSY
    Nicholas Barbaro; Fiscal Year: 2002
    DESCRIPTION (Applicant's Abstract): The purpose of this study is to determine whether gamma knife radiosurgery is effective in reducing or eliminating seizures in patients with temporal lobe epilepsy...
  22. Image-Guided Radiation Therapy and Radiosurgery for Small Animals
    David Kirsch; Fiscal Year: 2009
    ..Combining this novel instrument with the extensive expertise in radiation biology at Duke will bring about new discoveries and will facilitate their translation into improved cancer therapy. ..
  23. Polysaccharide Hydrogel Fillers for Arteriovenous Malformation
    Weiliam Chen; Fiscal Year: 2007
    ..Even though this mode of treatment is generally regarded as a better alternative to surgical resection and radiosurgery, there are major limitations and risks leading to their lack of universal acceptance as leader in the field...
  24. DOSE COMPARISON OF STEREOTACTIC RADIOSURGICAL MODALITIES
    Mark Phillips; Fiscal Year: 1992
    Different techniques of small field stereotaxic external beam radiotherapy, also known as stereotactic radiosurgery, or intracranial lesions will be compared by means of dose distributions calculated using a CT-based, 3- dimensional ..
  25. APPROACHES TO BRAIN TUMOR THERAPY
    Steven Brem; Fiscal Year: 2002
    ..new drug development, Phase I and II c l i nical trials; (6) state-of-the-art radiation therapy; stereotactic radiosurgery; - computer-driven, navigational neurosurgery; and advanced MR neuroimaging; (7) expertise in biostatistics, ..
  26. Natural History and Treatment Response of AVMs
    ALEXANDER HALIM; Fiscal Year: 2002
    ..involving the relative efficacies of the 2 most practiced treatment modalities: open surgery and stereotactic radiosurgery. Most of what is known about BAVM comes from referral series...
  27. Development of High Throughput Screening Assays (RMI)
    Steven Rosenfeld; Fiscal Year: 2004
    ..This invasiveness greatly limits the effectiveness of local therapies, such as surgery, radiosurgery, and brachytherapy. Second, these tumors are very effective at generating their own blood supply...
  28. THE LATE EFFECTS OF NORMAL TISSUE (LENT) IV CONFERENCE
    Andrea Trotti; Fiscal Year: 2002
    ..g. conformal radiation therapy, radiosurgery, radionuclide therapy, high-dose rate brachytherapy, intensity-modulated radiation therapy), and the aggressive ..
  29. Brain Tumor Therapy: Radio Surgery vs. MR-Guided Ablat;
    Shantanu Sinha; Fiscal Year: 2005
    ..Conventional treatment options, including radical surgery, radiation therapy and stereotactic radiosurgery, are often accompanied by systemic side effects, long hospital stays and morbidity...
  30. RADIOSURGERY OF ARTERIOVENOUS MALFORMATION MODELS
    Reza Jahan; Fiscal Year: 2002
    Despite an expanding role of stereotactic radiosurgery, a number of key questions remain unanswered regarding the fundamental radiobiological and histopathological mechanisms contributing to radiosurgical obliteration of brain ..
  31. DYNAMIC FIELD SHAPING/STEREOTACTIC RADIOSURGERY DOSES
    Dennis Leavitt; Fiscal Year: 1993
    The circular field defining apertures commonly used in isocentrically focussed high-dose irradiation (termed radiosurgery) used in treatment of surgically inaccessible vascular malformations, benign acoustic neuromas, or other focal ..
  32. Response to Fractionated radiation Therapy by MRSI
    Sarah Nelson; Fiscal Year: 2007
    ..that MRSI is superior to conventional MR imaging for predicting outcome and following response to Gamma Knife Radiosurgery (GK-RS) in recurrent gliomas...
  33. Neural stem cell and brain plasticity after stroke
    Jialing Liu; Fiscal Year: 2005
    ..Experiments will determine whether the depletion of dentate gyrus progenitor cells by radiosurgery affects the structure of dentate gyrus and the functional recovery after focal ischemia...
  34. Glioma Therapy Using Targeted Oncolytic HSV Vectors
    Joseph C Glorioso; Fiscal Year: 2010
    ..Throughout this investigationvector performanceand tumor killing will be evaluated in combinationwith radiosurgery. We will use the performance of G207 as a benchmark with which to compare any vector improvements...
  35. PEDIATRIC BRAIN TUMOR CONSORTIUM--CHOP MEMBERSHIP
    Peter Phillips; Fiscal Year: 2003
    ..MRSpectroscopy, PET, SPECT), neurosurgery (computer image-guided surgery), and radiation therapy (stereotaxic radiosurgery, Gamma Knife, brachytherapy); (4) an NIH-funded brain tumor bank which stores brain tumor biopsies from CHOP, ..
  36. PEDIATRIC BRAIN TUMOR CLINICAL TRIAL CONSORTIUM
    Michael Prados; Fiscal Year: 2003
    ..therapy and unique drug therapy will be available, including but not limited to interstitial brachytherapy, radiosurgery, and experimental chemotherapy and gene therapy...
  37. Fast PET Dosimetry for Proton Therapy
    IRVING WEINBERG; Fiscal Year: 2009
    ..e., radiosurgery)...
  38. Quality of Life in Patients with Brain Metastases
    Joseph King; Fiscal Year: 2005
    ..well-controlled systemic disease are candidates for local therapy such as surgical resection or stereotactic radiosurgery. Randomized trials have shown that surgical resection of solitary brain metastases improves survival and ..
  39. Deterministic Radiotherapy Dose Calculation Method
    Todd Wareing; Fiscal Year: 2005
    ..of more precise beam delivery methods such as Intensity Modulated Radiation Therapy (IMRT) and Stereotactic Radiosurgery (SRS), the potential exists to substantially reduce margins and improve dose conformity...
  40. EFFICIENT GENERATION OF OPTIMAL MULTIBEAM IMRT PLANS
    Robert Levine; Fiscal Year: 1999
    ..The proposed algorithms will assist the radiotherapy and radiosurgery planner in the efficient design of MeV photon therapy beams to conform dose to the tumor and avoid exposure of ..
  41. TREATMENT OF MALIGNANT BRAIN TUMORS
    Mitchel Berger; Fiscal Year: 1999
    ..Fike will define the critical radiation dose-volume relationships for radiosurgery, so that clinical treatments provided by using this modality can be optimized for safety and efficacy...
  42. COMPUTER ASSISTED STEREOTAXIC NEUROSURGICAL SYSTEM
    ROBERT RIKER; Fiscal Year: 1992
    ..4) Development of Visualization Tools, 5) Multi-Modality Coregistration, 6) Stereotaxic Brachytherapy and Radiosurgery Capabilities, 7) Documentation, 8) Adjustable Imaging Adapter Design and Phototyping, 9) Accuracy Testing and ..
  43. OPTIMIZATION OF CANCER RADIATION THERAPY PLANNING
    Jorge Llacer; Fiscal Year: 2000
    ..is now coming to the forefront as the correct way to treat patients with difficult tumors by radiation and for Radiosurgery. Further licensing of the method by other large commercial companies in the field is then expected...
  44. Nanogold-Enhanced Radiosurgery for Malignant Brain Tumors
    James Hainfeld; Fiscal Year: 2008
    ..earlier studies in safely ablating malignant EMT-6 carcinomas in the thighs of mice by using photoactivation radiosurgery mediated by gold nanoparticles (so-called metal-enhanced radiosurgery [MERS])...
  45. CHRONOBIOLOGY OF PARTIAL EPILEPSY
    Mark Quigg; Fiscal Year: 2002
    ..In summary, these studies will provide insight into the chronoblological factors that facilitate partial seizure expression and may provide new perspectives into treatments for poorly controlled partial epilepsy. ..
  46. Spinal Cord Tolerance to Radiosurgical Dose Delivery
    Paul M Medin; Fiscal Year: 2010
    ..Advances in image-guided stereotactic radiosurgery (SRS) techniques have enabled the irradiation of spinal and paraspinal neoplasms with an accuracy and dose ..
  47. RADIATION ARTERIOPATHY IN A TRANSGENIC AV FISTULA MODEL
    Michael Lawton; Fiscal Year: 2004
    ..If NO and TGF-01 are involved in the radiation arteriopathy of AVMs, they might be used to enhance the efficacy of conventional stereotactic radiosurgery as part of a gene therapy for high-grade cerebral AVMs.
  48. EXPERIMENTAL RADIOTHERAPY--BASIS AND MODIFICATION
    John Brown; Fiscal Year: 2002
    ..To test this hypothesis we will employ inhibitors of the topo II catalytic cycle as well as cells induced to express high levels of topo II following TPZ treatment ..
  49. Digital tomosynthesis: a new paradigm for radiation treatment verification
    Fang Fang Yin; Fiscal Year: 2008
    ..This more frequent and broader range of application will translate into more consistent elimination of tumor and into less damage to nearby healthy tissue. [unreadable] [unreadable] [unreadable]..
  50. DEVELOPMENT OF NEW HYPOXIC CYTOTOXINS FOR CANCER THERAPY
    John Brown; Fiscal Year: 2008
    ..abstract_text> ..
  51. Epigenetic Potentiation of Interferon using Decitabine
    Wolfram Samlowski; Fiscal Year: 2008
    ..Additional experiments will evaluate interferon signaling and DNA damage response pathways in normal and neoplastic cells. [unreadable] [unreadable] [unreadable]..
  52. Four-dimensional IMAT planning using graph algorithms
    Cedric X Yu; Fiscal Year: 2010
    ..Successful achievement of the aforementioned project aims will provide planning and practical image guidance for the safe and efficient delivery of IMAT, and significantly improve cancer treatments. ..
  53. Experimental Radiotherapy and Chemotherapy With a Potent New Hypoxic Cytotoxin
    JOHN MARTIN BROWN; Fiscal Year: 2010
    ....
  54. Electromagnetic Tracking of Tumors for Radiotherapy
    Martin Murphy; Fiscal Year: 2006
    ..The augmented Calypso targeting system will be designed for integration into existing radiation therapy systems to provide enhanced beam targeting capability. [unreadable] [unreadable]..
  55. Meningioma: Risk Factors and Quality of Life
    Peter M Black; Fiscal Year: 2010
    ..This study represents the first concentratedeffort to examine environmental and genetic risk factors for meningioma. ..
  56. Effect of Estrogen on Radiation-induced Cataractogenesis
    JOSEPH DYNLACHT; Fiscal Year: 2005
    ..abstract_text> ..
  57. Yeast Gene Ontology by Phenotypic Profiling
    John Brown; Fiscal Year: 2007
    ..abstract_text> ..
  58. THERAPEUTICS STUDIES OF PRIMARY CNS MALIGNANCIES
    Patrick Wen; Fiscal Year: 2008
    ..abstract_text> ..
  59. CLINICAL RESEARCH IN NEURO-ONCOLOGY
    ROY PATCHELL; Fiscal Year: 2004
    ..abstract_text> ..
  60. The Role of the Mre11 Complex in Heat-radiosensitization
    JOSEPH DYNLACHT; Fiscal Year: 2007
    ..We will also determine the role of HR in heat-radiosensitization using silencing RNA (siRNA) targeting technology or conditional mutants deficient in specific NHEJ or HR proteins. [unreadable] [unreadable]..