high energy radiotherapy

Summary

Summary: Radiotherapy using high-energy (megavolt or higher) ionizing radiation. Types of radiation include gamma rays, produced by a radioisotope within a teletherapy unit; x-rays, electrons, protons, alpha particles (helium ions) and heavy charged ions, produced by particle acceleration; and neutrons and pi-mesons (pions), produced as secondary particles following bombardment of a target with a primary particle.

Top Publications

  1. ncbi Experimental determination of electron source parameters for accurate Monte Carlo calculation of large field electron therapy
    Vicky W Huang
    Medical Physics Unit, McGill University, 1650 Cedar Ave Montreal, Quebec H3G 1A4, Canada
    Phys Med Biol 50:779-86. 2005
  2. ncbi Final Aperture Superposition Technique applied to fast calculation of electron output factors and depth dose curves
    B A Faddegon
    Department of Radiation Oncology, UCSF, San Francisco, California 94143 1708, USA
    Med Phys 32:3286-94. 2005
  3. ncbi Dual scattering foil design for poly-energetic electron beams
    K K Kainz
    Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030 4009, USA
    Phys Med Biol 50:755-67. 2005
  4. ncbi Effect of beamlet step-size on IMRT plan quality
    Guowei Zhang
    Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Med Phys 32:3448-54. 2005
  5. ncbi Photonuclear dose calculations for high-energy photon beams from Siemens and Varian linacs
    Omar Chibani
    Department of Radiation Oncology, Massy Cancer Center, Virginia Commonwealth University, 401 College Street, Richmond, Virginia 23298, USA
    Med Phys 30:1990-2000. 2003
  6. ncbi A dose verification method using a monitor unit matrix for dynamic IMRT on Varian linear accelerators
    Xuangen Chen
    University of Pittsburgh Cancer Institute, Department of Radiation Oncology, PA 15901, USA
    Phys Med Biol 50:5641-52. 2005
  7. ncbi Monte Carlo modelling of external radiotherapy photon beams
    Frank Verhaegen
    Medical Physics Unit, McGill University, 1650 Cedar Av Montreal, Quebec, H3G1A4, Canada
    Phys Med Biol 48:R107-64. 2003
  8. ncbi Deterministic photon transport calculations in general geometry for external beam radiation therapy
    M L Williams
    Department of Physics and Astronomy, Medical Physics Group, Louisiana State University, Baton Rouge, Louisiana 70803, USA
    Med Phys 30:3183-95. 2003
  9. ncbi Backscattered dose perturbation effects at metallic interfaces irradiated by high-energy X- and gamma-ray therapeutic beams
    Manickam Ravikumar
    Department of Radiation Physics, Kidwai Memorial Institute of Oncology, Bangalore, India
    Strahlenther Onkol 180:173-8. 2004
  10. ncbi Dosimetric characteristics of the Elekta Beam Modulator
    I Patel
    North Western Medical Physics, Radiotherapy Department, Rosemere Cancer Centre, Royal Preston Hospital, UK
    Phys Med Biol 50:5479-92. 2005

Detail Information

Publications234 found, 100 shown here

  1. ncbi Experimental determination of electron source parameters for accurate Monte Carlo calculation of large field electron therapy
    Vicky W Huang
    Medical Physics Unit, McGill University, 1650 Cedar Ave Montreal, Quebec H3G 1A4, Canada
    Phys Med Biol 50:779-86. 2005
    ..This model can potentially provide a solution to the Monte Carlo validation of large field electron beam therapy...
  2. ncbi Final Aperture Superposition Technique applied to fast calculation of electron output factors and depth dose curves
    B A Faddegon
    Department of Radiation Oncology, UCSF, San Francisco, California 94143 1708, USA
    Med Phys 32:3286-94. 2005
    ..5% exceeded the statistical precision of the calculation by four standard deviations. This occurred at 18 MeV for the 2.5 x 2.5 cm2 field. The differences are due to the method used to account for the collimator effect...
  3. ncbi Dual scattering foil design for poly-energetic electron beams
    K K Kainz
    Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030 4009, USA
    Phys Med Biol 50:755-67. 2005
    ..Further studies of the dosimetric properties of LWFA-generated electron beams will be done using Monte Carlo methods...
  4. ncbi Effect of beamlet step-size on IMRT plan quality
    Guowei Zhang
    Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Med Phys 32:3448-54. 2005
    ..0, 7.6, 8.7, and 9.1 dose%/mm achieved for beamlet step sizes of 10, 5, 2, and 1 mm, respectively...
  5. ncbi Photonuclear dose calculations for high-energy photon beams from Siemens and Varian linacs
    Omar Chibani
    Department of Radiation Oncology, Massy Cancer Center, Virginia Commonwealth University, 401 College Street, Richmond, Virginia 23298, USA
    Med Phys 30:1990-2000. 2003
    ..1, 1.1, and 2.0% likelihood of fatal secondary cancer for a 70 Gy treatment delivered by the Siemens 18 MV, Varian 15 MV, and Varian 18 MV beams, respectively...
  6. ncbi A dose verification method using a monitor unit matrix for dynamic IMRT on Varian linear accelerators
    Xuangen Chen
    University of Pittsburgh Cancer Institute, Department of Radiation Oncology, PA 15901, USA
    Phys Med Biol 50:5641-52. 2005
    ..The doses computed using the method were compared with both measurement and treatment planning for 14 and 25 plans respectively. An average of less than 2% agreement was observed and the standard deviation was about 1.9%...
  7. ncbi Monte Carlo modelling of external radiotherapy photon beams
    Frank Verhaegen
    Medical Physics Unit, McGill University, 1650 Cedar Av Montreal, Quebec, H3G1A4, Canada
    Phys Med Biol 48:R107-64. 2003
    ..The review will be focused mainly on Monte Carlo modelling of linear accelerator treatment heads but sections will also be devoted to kilovoltage x-ray units and 60Co teletherapy sources...
  8. ncbi Deterministic photon transport calculations in general geometry for external beam radiation therapy
    M L Williams
    Department of Physics and Astronomy, Medical Physics Group, Louisiana State University, Baton Rouge, Louisiana 70803, USA
    Med Phys 30:3183-95. 2003
    ..However additional development is needed to provide capability for 3D electron transport calculations...
  9. ncbi Backscattered dose perturbation effects at metallic interfaces irradiated by high-energy X- and gamma-ray therapeutic beams
    Manickam Ravikumar
    Department of Radiation Physics, Kidwai Memorial Institute of Oncology, Bangalore, India
    Strahlenther Onkol 180:173-8. 2004
    ..To analyze backscattered dose enhancements near different metallic interfaces for cobalt-60 ((60)Co) gamma rays and 6- and 18-MV photon beams...
  10. ncbi Dosimetric characteristics of the Elekta Beam Modulator
    I Patel
    North Western Medical Physics, Radiotherapy Department, Rosemere Cancer Centre, Royal Preston Hospital, UK
    Phys Med Biol 50:5479-92. 2005
    ..The maximum interleaf leakage was found to be 1.7% and the average leaf transmission less than 1.0%. No major differences were observed in leakage and transmission with changing gantry angle...
  11. ncbi Dosimetric validation of the anisotropic analytical algorithm for photon dose calculation: fundamental characterization in water
    Antonella Fogliata
    Oncology Institute of Southern Switzerland, Medical Physics Unit, Bellinzona, Switzerland
    Phys Med Biol 51:1421-38. 2006
    ..Additional tests were carried out for enhanced dynamic wedges with results comparable to previous results. The basic dosimetric validation of the AAA was therefore considered satisfactory...
  12. ncbi Experimental determination of beam quality factors, kQ, for two types of Farmer chamber in a 10 MV photon and a 175 MeV proton beam
    Joakim Medin
    Department of Medical Radiation Physics, Lund University, Malmo University Hospital, SE 205 02 Malmo, Sweden
    Phys Med Biol 51:1503-21. 2006
    ..6%. Including this estimated result in the proton beam would increase the determined (w(air)/e)(Q) value by the same amount...
  13. ncbi Application of the electron pencil beam redefinition algorithm to electron arc therapy
    Pai Chun M Chi
    Department of Radiation Physics, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA
    Med Phys 33:2369-83. 2006
    ....
  14. ncbi Are neutrons responsible for the dose discrepancies between Monte Carlo calculations and measurements in the build-up region for a high-energy photon beam?
    George X Ding
    Medical Physics, Fraser Valley Cancer Centre, British Columbia Cancer Agency, Surrey, Canada
    Phys Med Biol 47:3251-61. 2002
    ..Therefore, neutrons present in a high-energy photon beam were unlikely to be responsible for the reported discrepancies in the build-up region for large fields...
  15. ncbi On the effective point of measurement in megavoltage photon beams
    Iwan Kawrakow
    Ionizing Radiation Standards, NRC, Ottawa, K1A 0R6
    Med Phys 33:1829-39. 2006
    ..On the other hand, once the effective point of measurement is selected appropriately, measured depth-ionization curves can be equated to measured depth-dose curves for all depths within +/- 0.5%...
  16. ncbi Ultra-thin TLDs for skin dose determination in high energy photon beams
    S Stathakis
    Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Phys Med Biol 51:3549-67. 2006
    ..Knowing the dose received at the surface of the patient can lead to prediction of skin reactions helping with the design of new treatment techniques and alternative dose fractionation schemes...
  17. ncbi Perturbation factors for cylindrical ionization chambers in proton beams. Part I: corrections for gradients
    Hugo Palmans
    National Physical Laboratory, Radiation Dosimetry Team, Hampton Road, Teddington, Middx, TW11 0LW, UK
    Phys Med Biol 51:3483-501. 2006
    ..This is illustrated by successfully applying it to depth-dose measurements with cylindrical ionization chambers taken from the literature...
  18. ncbi Two-dimensional and quasi-three-dimensional dosimetry of hadron and photon beams with the Magic Cube and the Pixel Ionization Chamber
    R Cirio
    Experimental Physics Department of the University and Istituto Nazionale di Fisica Nucleare, Via P Giuria 1, I 10125 Torino, Italy
    Phys Med Biol 49:3713-24. 2004
    ..The PXC has been used to verify dynamic intensity-modulated radiotherapy for head-and-neck and breast cancers...
  19. ncbi Dose discrepancies between Monte Carlo calculations and measurements in the buildup region for a high-energy photon beam
    George X Ding
    Medical Physics, Fraser Valley Cancer Centre, British Columbia Cancer Agency, Surrey, BC, V3V 1Z2 Canada
    Med Phys 29:2459-63. 2002
    ..At a depth of 1 cm, discrepancies of about 5% are still observed in the buildup region for the field with the lead foil. Therefore a new explanation for the unresolved discrepancy remains to be found...
  20. ncbi Monte Carlo correction factors for a Farmer 0.6 cm3 ion chamber dose measurement in the build-up region of the 6 MV clinical beam
    J Pena
    Departamento de Física de Partículas, Universidade de Santiago de Compostela, Santiago de Compostela, Spain
    Phys Med Biol 51:1523-32. 2006
    ..The corrected percentage depth dose (PDD) agrees within 2% with that measured using the NACP 02 plane-parallel ion chamber in the build-up region at depths greater than 0.4 cm, where the Farmer chamber wall reaches the phantom surface...
  21. ncbi Calculations of neutron dose equivalent exposures from range-modulated proton therapy beams
    Jerimy C Polf
    Department of Radiation Physics, Unit 130, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Phys Med Biol 50:3859-73. 2005
    ..In general, H/D increased with increasing range modulation at all locations studied, and the maximum H/D exposures shifted away from isocentre...
  22. ncbi Beam modeling and verification of a photon beam multisource model
    Anders Ahnesjö
    Nucletron Scandinavia AB, Box 1704, 751 47 Uppsala, Sweden
    Med Phys 32:1722-37. 2005
    ..Internal, motorized wedges did yield slightly larger errors than external wedges. These results reflect the increased complexity, both experimentally and computationally, when wedges are used compared to open beams...
  23. ncbi Monte Carlo dose calculations for spot scanned proton therapy
    A Tourovsky
    Division of Radiation Medicine, Paul Scherrer Institute PSI, Villigen, Switzerland
    Phys Med Biol 50:971-81. 2005
    ....
  24. ncbi Monte Carlo based modulated electron beam treatment planning using a few-leaf electron collimator--feasibility study
    Khalid Al-Yahya
    Medical Physics Unit, McGill University, 1650 Cedar Avenue, Montreal H3G 1A9, Canada
    Phys Med Biol 50:847-57. 2005
    ..Estimates of delivery times are made and show that a full treatment fraction can be kept to 15 min or less...
  25. ncbi Monte Carlo source model for photon beam radiotherapy: photon source characteristics
    Michael K Fix
    Department of Radiation Oncology, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    Med Phys 31:3106-21. 2004
    ....
  26. ncbi Spectrum reconstruction from dose measurements as a linear inverse problem
    Benjamin Armbruster
    Department of Mathematics, University of Arizona, Tucson, AZ 85721, USA
    Phys Med Biol 49:5087-99. 2004
    ..We illustrate this theory with simulations and an example utilizing six sets of dose measurements with water and lead as attenuators...
  27. ncbi Reference photon dosimetry data and reference phase space data for the 6 MV photon beam from varian clinac 2100 series linear accelerators
    Sang Hyun Cho
    Department of Radiation Physics, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Med Phys 32:137-48. 2005
    ..g., 1% or 1 mm for depth dose). A complete set of the RPDD and RPSD from the current study is available from the RPC website (http://rpc.mdanderson.org) or via mass storage media such as DVD or CD-ROM upon request...
  28. ncbi Comparison of build-up dose between Elekta and Varian linear accelerators for high-energy photon beams using radiochromic film and clinical implications for IMRT head and neck treatments
    L Paelinck
    Ghent University Hospital, De Pintelaan 185, B 9000 Gent, Belgium
    Phys Med Biol 50:413-28. 2005
    ....
  29. ncbi Implementation of random set-up errors in Monte Carlo calculated dynamic IMRT treatment plans
    S Stapleton
    Department of Physics and Astronomy, University of Victoria, Victoria BC, Canada
    Phys Med Biol 50:429-39. 2005
    ..It also showed that accounting for the set-up errors could be essential for correct identification of the value and position of the hot spot...
  30. ncbi A generalized extension to the Hounsell-Wilkinson head scatter model
    J Byrne
    Regional Medical Physics Department, Newcastle General Hospital, Newcastle upon Tyne, NE4 6BE, UK
    Phys Med Biol 49:N277-85. 2004
    ..We present a generalized extension to Hounsell and Wilkinson's model and present results for typical treatment field shapes on a Siemens Primus linear accelerator...
  31. ncbi Linear energy transfer dependence of a normoxic polymer gel dosimeter investigated using proton beam absorbed dose measurements
    Helen Gustavsson
    Department of Medical Radiation Physics, Lund University, Malmo University Hospital, SE 205 02, Malmo, Sweden
    Phys Med Biol 49:3847-55. 2004
    ..9 keV microm(-1), thus indicating that the behaviour of the polymer gel dosimeter would not be altered for the range of LET values expected in the case of photons or electrons in a clinical range of energies...
  32. ncbi Geometric leaf placement strategies
    J D Fenwick
    Department of Physics, Clatterbridge, Centre for Oncology, Clatterbridge Road, Bebington, Wirral CH63 4JY, UK
    Phys Med Biol 49:1505-19. 2004
    ....
  33. ncbi Correction for dose-response variations in a scanning liquid ion chamber EPID as a function of linac gantry angle
    P W Chin
    Department of Medical Physics, Velindre Cancer Centre, Cardiff CF14 2TL, Wales, UK
    Phys Med Biol 49:N93-103. 2004
    ..Since the artefacts compromise both accurate dosimetry and image quality, their successful removal should benefit a broad range of SLIC EPID applications...
  34. ncbi A novel method to correct for pitch and yaw patient setup errors in helical tomotherapy
    Sarah A Boswell
    Department of Medical Physics, University of Wisconsin, Madison, Wisconsin 53706, USA
    Med Phys 32:1630-9. 2005
    ..Rotational corrections about an axis perpendicular to the transverse plane continue to be implemented easily in tomotherapy by adjustment of the initial gantry angle...
  35. ncbi Photon-beam subsource sensitivity to the initial electron-beam parameters
    Michael K Fix
    Department of Radiation Oncology, Virginia Commonwealth University, PO Box 980058, Richmond, Virginia 23298, USA
    Med Phys 32:1164-75. 2005
    ....
  36. ncbi Experimental simulation of A-bomb gamma ray spectra: revisited
    John E Pattison
    School of Physics and Electronic Systems Engineering, University of South Australia, Mawson Lakes, 5095, Australia
    Radiat Prot Dosimetry 109:175-80. 2004
    ..16 for Hiroshima and Nagasaki, respectively. These results provide further confirmation of the acceptability of the simple cylindrically symmetrical body models employed in these studies to represent the average Japanese survivor...
  37. ncbi Online compensation for target motion with scanned particle beams: simulation environment
    Qiang Li
    Institute of Modem Physics, Chinese Academy of Sciences, Lanzhou 730000, People s Republic of China
    Phys Med Biol 49:3029-46. 2004
    ..It contributes a substantial basis for the experimental research on the irradiation of moving target volumes with scanned ion beams at GSI which will be presented in upcoming papers...
  38. ncbi Intensity-modulated radiation therapy: overlapping co-axial modulated fields
    P Metcalfe
    Centre for Medical Radiation Physics, University of Wollongong, NSW, Australia
    Phys Med Biol 49:3629-37. 2004
    ..5 cGy in a modulated field at d(max). While the magnitude of the dose differences are small improved round end leaf modelling combined with a finer dose calculation grid may minimize the discrepancy between calculated and delivered dose...
  39. ncbi Response corrections for solid-state detectors in megavoltage photon dosimetry
    Z Yin
    School of Physics and Astronomy, University of Birmingham, Birmingham B15 2TT, UK
    Phys Med Biol 49:3691-702. 2004
    ..The model predicts the effect to within 1% for both energies offering a basis for the correction of diodes for use in routine dosimetry...
  40. ncbi Portal dose image prediction for dosimetric treatment verification in radiotherapy. II. An algorithm for wedged beams
    Kasper L Pasma
    Department of Radiotherapy, Daniel den Hoed Cancer Center University Hospital Rotterdam, The Netherlands
    Med Phys 29:925-31. 2002
    ..For low and high energy photon beams (6 and 23 MV) good agreement (approximately 1%) has been found between calculated and measured transmissions for a slab and a thorax phantom...
  41. ncbi Density heterogeneities and the influence of multiple Coulomb and nuclear scatterings on the Bragg peak distal edge of proton therapy beams
    Gabriel O Sawakuchi
    Department of Radiation Physics, Unit 94, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Phys Med Biol 53:4605-19. 2008
    ..This method is tested for three clinical setups of a voxelized model of a human head based on computer tomography data. Results are within 3% of the distal fall-off values obtained using Monte Carlo simulations...
  42. ncbi Automatic determination of primary electron beam parameters in Monte Carlo simulation
    Javier Pena
    Departamento de Física de Partículas, Facultade de Fisica, Universidade de Santiago de Compostela, Spain
    Med Phys 34:1076-84. 2007
    ..These databases can also be used to characterize any accelerators of the same model from different sites...
  43. ncbi A beam source model for scanned proton beams
    Peter Kimstrand
    Section of Oncology, Department of Oncology, Radiology and Clinical Immunology, Uppsala University, Akademiska sjukhuset, S 751 85 Uppsala, Sweden
    Phys Med Biol 52:3151-68. 2007
    ..For a set of four individual pencil beams, both with the full energy and range shifted, 96.5% (99.8%) of the tested dose points satisfied the 1%/1 mm (2%/2 mm) gamma criterion...
  44. ncbi Dosimetric features of linac head and phantom scattered radiation outside the clinical photon beam: experimental measurements and comparison with treatment planning system calculations
    L Cozzi
    Radiation Oncology Division, Medical Physics Unit, Istituto Oncologico della Svizzera Italiana, Ospedale S. Giovanni, 6504 Bellinzona, Switzerland
    Radiother Oncol 58:193-200. 2001
    ....
  45. ncbi Interface perturbation effects in high-energy electron beams
    Frank Verhaegen
    Medical Physics Department, McGill University, Montreal General Hospital, 1650 Cedar Avenue, Montreal, Quebec, H3G1A4 Canada
    Phys Med Biol 48:687-705. 2003
    ..It is concluded that EGSnrc is a highly suitable tool for electron interface dosimetry studies...
  46. ncbi Shielding design for a laser-accelerated proton therapy system
    J Fan
    Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Phys Med Biol 52:3913-30. 2007
    ..It is shown that the two-layer shielding design with 10-12 cm thick polyethylene and 4 cm thick lead can effectively absorb the unwanted particles to meet the shielding requirements...
  47. ncbi Field-size dependence of doses of therapeutic carbon beams
    Yohsuke Kusano
    Tokai University Unified Graduate School, Graduate School of Science and Technology, 1117 Kitakaname, Hiratsuka, Kanagawa 259 1207, Japan
    Med Phys 34:4016-22. 2007
    ..The reconstructed beam was also used for irregularly shaped fields. The resultant dose distribution agreed with the measured dose distribution. The reconstructed beams were found to be applicable to the treatment-planning system...
  48. ncbi Initial beam size study for passive scatter proton therapy. I. Monte Carlo verification
    Jerimy C Polf
    Department of Radiation Physics, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA
    Med Phys 34:4213-8. 2007
    ....
  49. ncbi Initial beam size study for passive scatter proton therapy. II. Changes in delivered depth dose profiles
    Jerimy C Polf
    Department of Radiation Physics, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA
    Med Phys 34:4219-22. 2007
    ..Our results indicate that the width of the delivered SOBP decreases as the size of the initial beam increases...
  50. ncbi Dose attenuation effect of hip prostheses in a 9-MV photon beam: commercial treatment planning system versus Monte Carlo calculations
    Asghar Mesbahi
    Medical Physics Department, Medical School, Tabriz University of Medical Sciences, Tabriz, Iran
    Radiat Med 25:529-35. 2007
    ..The purpose of this study was to investigate the dosimetric effect of various hip prostheses on pelvis lateral fields treated by a 9-MV photon beam using Monte Carlo (MC) and effective path-length (EPL) methods...
  51. ncbi Clinical results of entrance dose in vivo dosimetry for high energy photons in external beam radiotherapy using MOSFETs
    J P Morton
    Department of Physics IT and Engineering, Adelaide Radiotherapy Centre, Adelaide, Australia
    Australas Phys Eng Sci Med 30:252-9. 2007
    ..D. of 2.8%. Prostates had a mean discrepancy of 1.3% and S.D. of 2.9%. For 3 fields combined, prostates had a mean of 1.3% and S.D. of 1.8%. These results are similar to results obtained with diodes and TLDs for the same techniques...
  52. ncbi Prototyping a large field size IORT applicator for a mobile linear accelerator
    Rogier W J Janssen
    Catharina Hospital Eindhoven, PO Box 1350, 5602 ZA, Eindhoven, The Netherlands
    Phys Med Biol 53:2089-102. 2008
    ..In addition, the measurements agreed well with the MC simulations, typically within 2%/1 mm...
  53. ncbi Optimization of photon beam flatness for radiation therapy
    Jörgen Olofsson
    Department of Radiation Sciences Radiation Physics, Umea University, SE 901 87 Umea, Sweden
    Phys Med Biol 52:1735-46. 2007
    ....
  54. ncbi The influence of output measurement time interval and tolerance on treatment dose deviation in photon external beam radiotherapy
    Mika Kapanen
    Radiation and Nuclear Safety Authority, STUK, Laippatie 4, 00881 Helsinki, Finland
    Phys Med Biol 51:4857-67. 2006
    ..The results suggest that similar treatment quality can be achieved by doubling the output measurement time interval and lowering the action level from +/-2% to +/-1.5% and the constancy check action level from +/-3% to +/-2%...
  55. ncbi Incorporation of the aperture thickness in proton pencil-beam dose calculations
    Roelf L Slopsema
    Francis H Burr Proton Therapy Center, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Phys Med Biol 51:5441-53. 2006
    ..The overall effect depends on the aperture thickness, the position of the aperture edge and the intrinsic source size and SAD, but is fairly insensitive to aperture-to-skin distance and depth in patient...
  56. ncbi Determination of the recombination correction factor kS for some specific plane-parallel and cylindrical ionization chambers in pulsed photon and electron beams
    G Bruggmoser
    Univ Klinikum Freiburg, Klinik f Strahlenheilkunde, FB Med Physik, Freiburg, Germany
    Phys Med Biol 52:N35-50. 2007
    ....
  57. ncbi Experimental determination of the effect of detector size on profile measurements in narrow photon beams
    E Pappas
    Department of Medical Physics, Faculty of Medicine, University of Crete, 711 10 Stavrakia Heraklion, Crete, Greece
    Med Phys 33:3700-10. 2006
    ..The response kernels of any desired detector can be derived, allowing the elimination of the errors associated with narrow beam profile measurements...
  58. ncbi Head scatter off-axis for megavoltage x rays
    Timothy C Zhu
    Department of Radiation Oncology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Med Phys 30:533-43. 2003
    ..It exceeds the leakage through the collimator 2 cm outside the edge for square fields c>10 cm. Monte Carlo calculations showed considerably less head scatter outside the field than measurements...
  59. ncbi Skin dose measurement by using ultra-thin TLDs
    J P Lin
    Department of Nuclear Science, National Tsing Hua University, Hsinchu, Taiwan
    Appl Radiat Isot 55:383-91. 2001
    ..59+/-1.72%, 78.52+/-2.99%, 78.89+/-2.86%, 86.08+/-2.62%. 87.75+/-1.94% and 86.33+/-3.09% for 6, 9, 12, 15, 18 and 21 MeV, respectively. They also increase with a larger size. The oblique factors also increase with larger incident angle...
  60. ncbi Clinical tolerance in large field radiotherapy--the knowledge gained over the last ten years
    Lilia B Gocheva
    Clinic of Radotherapy, University Hospital Tzarica Yoanna ISUL, Sofia, Bulgaria
    Folia Med (Plovdiv) 52:14-21. 2010
    ..far from being successfully managed in spite of the apparent progress achieved by surgical treatment, high energy radiotherapy (RT) and chemotherapy (CHT)...
  61. ncbi A Monte Carlo model for out-of-field dose calculation from high-energy photon therapy
    Stephen F Kry
    Department of Radiation Physics, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Med Phys 34:3489-99. 2007
    ..This Monte Carlo model is useful to both physicists and clinicians when evaluating out-of-field doses and associated potential risks...
  62. ncbi Estimation of the dose at the maze entrance for x-rays from radiotherapy linear accelerators
    I A Al-Affan
    Medical Physics, Velindre NHS Trust, Cardiff, United Kingdom
    Med Phys 27:231-8. 2000
    ..measurements have shown that the NCRP formula to estimate the x radiation dose at the maze entrance of high energy radiotherapy rooms underestimates the dose by an order of magnitude...
  63. ncbi Review of clinical radioimmunotherapy
    Brad Pohlman
    Department of Hematologic Oncology and Blood Disorders, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Expert Rev Anticancer Ther 6:445-61. 2006
    ..The most likely pattern of use for this field in the next 5 years will probably involve combination or sequential regimens incorporating both radioimmunotherapy and more conventional chemotherapy or external radiotherapy...
  64. ncbi [Radiotherapy of locally advanced tumors of the mouth floor and the tongue]
    B Bonetti
    Istituto del Radio, O Alberti degli Spedali Civili di Brescia
    Acta Otorhinolaryngol Ital 10:79-86. 1990
    ..All underwent high energy radiotherapy associated, in 93 cases, with surgery on the T and/or on the N...
  65. ncbi Characteristics of the photoneutron contamination present in a high-energy radiotherapy treatment room
    H M Garnica-Garza
    Coordinación de Posgrado, Facultad de Medicina, Universidad Autonoma del Estado de Mexico, Paseo Tollocan S N, Toluca, Estado de México 50180, Mexico
    Phys Med Biol 50:531-9. 2005
    ..The transport of the photoneutrons across a treatment room corroborates the validity of empirical models, but the transmission across a concrete maze produces a dose-equivalent tenth-value layer that differs from previous data...
  66. ncbi Feasibility study of glass dosimeter postal dosimetry audit of high-energy radiotherapy photon beams
    Hideyuki Mizuno
    Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Inage Ku, Chiba, Japan
    Radiother Oncol 86:258-63. 2008
    ..Reproducibility, energy dependence, field size and depth dependence were compared to those of a thermoluminescence dosimeter (TLD), which has been the major tool for postal dose audits worldwide...
  67. ncbi Investigation of the neutron contamination in IMRT deliveries with a paired magnesium and boron coated magnesium ionization chamber system
    Julian Becker
    Department of Radiotherapy and Radio Oncology, University Medical Center Hamburg Eppendorf, University of Hamburg, Germany
    Radiother Oncol 86:182-6. 2008
    Photon beams used in IMRT treatments with high energies (>10 MV) are contaminated with neutrons. Measurement of this neutron dose is of significance to the overall risk estimate of high energy radiotherapy.
  68. ncbi Reduced neutron production through use of a flattening-filter-free accelerator
    Stephen F Kry
    Department of Radiation Physics, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Int J Radiat Oncol Biol Phys 68:1260-4. 2007
    ..To measure and compare neutron fluence around an accelerator operating at 18 MV, both with the flattening filter present (FF mode) and absent (flattening-filter-free [FFF] mode)...
  69. ncbi Monte Carlo evaluations of the absorbed dose and quality dependence of AL2O3 in radiotherapy photon beams
    Shao Wen Chen
    School of Physics Science and Engineering, Sun Yat Sen University, Guangzhou 510275, China
    Med Phys 36:4421-4. 2009
    ..The purpose of this work was to evaluate the absorbed dose to AL2O3 dosimeter at various depths of water phantom in radiotherapy photon beams by Monte Carlo simulation and evaluate the beam quality dependence...
  70. ncbi A study of radiotherapy modalities combined with continuous 5-FU infusion for locally advanced gastrointestinal malignancies
    S I Shibata
    Department of Medical Oncology and Therapeutics Research, City of Hope National Medical Center, 1500 E Duarte Road, Duarte, CA 91010, USA
    Eur J Surg Oncol 30:650-7. 2004
    ..We describe the feasibility of combining infusional 5-fluorouracil (5-FU) with intraoperative radiation therapy (IORT)...
  71. ncbi Radiotherapy services in countries in transition: gross national income per capita as a significant factor
    Victor Levin
    Section of Applied Radiation Biology and Radiotherapy, Division of Human Health, Department of Nuclear Sciences and Applications, International Atomic Energy Agency IAEA, Wagramer Strasse 5, P O Box 200, A 1400, Vienna, Austria
    Radiother Oncol 63:147-50. 2002
    ..This information has been analysed to provide guidance to countries commencing and expanding radiotherapy services...
  72. ncbi A Monte Carlo study on internal wedges using BEAM
    W van der Zee
    Department of Radiotherapy, University Medical Center Utrecht, The Netherlands
    Med Phys 29:876-85. 2002
    ..The ultimate solution will be to make this beam hardening depending on the actual position in the radiation field, as the photon energy varies over the field (holds also for open fields)...
  73. ncbi Effect of scatter material on diode detector performance for in vivo dosimetry
    S Best
    Department of Radiation Oncology, Royal Prince Alfred Hospital, Camperdown, Australia
    Phys Med Biol 53:89-97. 2008
    ..A diode design with minimal non-water-equivalent components and the addition of a 6 cm diameter water-equivalent disc for scatter material is recommended for the in vivo dosimetry of 6 MV complex fields...
  74. ncbi Internal high linear energy transfer (LET) targeted radiotherapy for cancer
    Barry J Allen
    Centre for Experimental Radiation Oncology, St George Cancer Care Centre, Gray St, Kogarah NSW 2217, Australia
    Phys Med Biol 51:R327-41. 2006
    ..This review charts, from an Australian perspective, the developing role of local and systemic high LET, internal radiation therapy...
  75. ncbi Effects of positioning uncertainty and breathing on dose delivery and radiation pneumonitis prediction in breast cancer
    Panayiotis Mavroidis
    Department of Medical Radiation Physics, Karolinska Institutet, Stockholm University, Sweden
    Acta Oncol 41:471-85. 2002
    ..The proposed treatment-plan adjustments taking positioning uncertainty and breathing effects into account indicate significant deviations in the dose delivery and the predicted lung complications...
  76. ncbi Characteristic features of a high-energy x-ray spectra estimation method based on the Waggener iterative perturbation principle
    Akira Iwasaki
    School of Health Sciences, Hirosaki University, 66 1 Hon cho, Hirosaki, Aomori 036 8564, Japan
    Med Phys 33:4056-63. 2006
    ....
  77. ncbi What can we expect from dose escalation using proton beams?
    J F Fowler
    Department of Human Oncology, Medical School of the University of Wisconsin, Madison, Wisconsin 53792, USA
    Clin Oncol (R Coll Radiol) 15:S10-5. 2003
    ..There is a considerable way to go yet to achieve really high non-recurrence rates, especially in the lung tumours. Proton beams would make this progress much safer and more effective than any variants with photons...
  78. ncbi The impact of skin washing with water and soap during breast irradiation: a randomized study
    I Roy
    Department of Radiation Oncology, , , 11, , Quebec City, Quebec, Canada
    Radiother Oncol 58:333-9. 2001
    ..CONCLUSION: Washing the irradiated skin during the course of radiotherapy for breast cancer is not associated with increased skin toxicity and should not be discouraged...
  79. ncbi Combined surgical excision and radiation therapy for keloid treatment
    Sadanori Akita
    Division of Plastic and Reconstructive Surgery, Department of Developmental and Reconstructive Medicine, Nagasaki University, Graduate School of Biomedical and Sciences, Nagasaki, Japan
    J Craniofac Surg 18:1164-9. 2007
    ..2% overall with none in craniofacial locations. Therefore, the combined treatment of surgical excision and postoperative electron beam irradiation is effective for scar quality and reducing the recurrence rate in long-term follow up...
  80. ncbi Long-term survival (superior to 20 years) after pancreaticoduodenectomy for pancreatic duct adenocarcinoma: report of two cases
    O Naseef
    Department of Digestive Surgery and Liver Transplantation, Edouard Herriot Hospital, Lyon, France
    Hepatogastroenterology 55:1110-1. 2008
    ..Both received adjuvant treatment and are currently alive after 21y 6 months and 22 y 2 months respectively. Very long term survival for PDA can be achieved for some patients who benefit from R0 resection...
  81. ncbi Focal and craniospinal irradiation for patients with intracranial germinoma and patterns of failure
    Quynh Nhu Nguyen
    Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 107:2228-36. 2006
    ..The authors compared the patterns of failure in patients with intracranial germinoma who were managed with either chemotherapy and focal irradiation or with craniospinal irradiation (CSI)...
  82. ncbi The case for particle therapy
    B Jones
    Queen Elizabeth University Hospital, Birmingham B15 2TH, UK
    Br J Radiol 79:24-31. 2006
    ....
  83. ncbi Test of GEANT3 and GEANT4 nuclear models for 160 MeV protons stopping in CH2
    H Paganetti
    Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, Massachusetts 02114 2696, USA
    Med Phys 30:1926-31. 2003
    ..The GEANT3/Fluka and GEANT4/precompound simulations agree moderately well with the observed range distribution. The data are given in a convenient form for testing other Monte Carlo programs...
  84. ncbi Tumour dose enhancement using modified megavoltage photon beams and contrast media
    James L Robar
    Vancouver Cancer Centre, BC Cancer Agency, Canada
    Phys Med Biol 47:2433-49. 2002
    ..In contrast to the phototherapy technique, which uses the orthovoltage beam from a modified CT scanner to achieve dose enhancement, all unflattened spectra preserve the dose build-up at the surface, and thus the skin and bone are spared...
  85. ncbi Dosimetric verification of modulated photon fields by means of compensators for a kernel model
    Lars Weber
    MDS Nordion AB, Box 1704, SE 751 47 Uppsala, Sweden
    Radiother Oncol 62:87-93. 2002
    ....
  86. ncbi Long-term results of treatment for prostate carcinoma by staging pelvic lymph node dissection and definitive irradiation using low-dose rate temporary iridium-192 interstitial implant and external beam radiotherapy
    A A Puthawala
    Department of Radiation Oncology, Long Beach Memorial Medical Center, Long Beach, California 90806, USA
    Cancer 92:2084-94. 2001
    ..The objective of this study was to evaluate long-term treatment outcome of definitive irradiation by using temporary interstitial implant and limited dose of external beam radiotherapy in treatment of localized prostate carcinoma...
  87. ncbi Experience of radiotherapy in lethal midline granuloma with special emphasis on centrofacial T-cell lymphoma: a retrospective analysis covering a 34-year period
    H H Chen
    Department of Radiation Oncology, National Cheng Kung University Hospital, Tainan, Taiwan
    Radiother Oncol 38:1-6. 1996
    ..The recent clarification of the disease nature and the recognition of the background clinicopathological features should provide valuable information for future patient management and prospective studies...
  88. ncbi Impact of radioimmunoscintigraphy on definition of clinical target volume for radiotherapy after prostatectomy
    Ashesh B Jani
    Department of Radiation and Cellular Oncology, University of Chicago Hospitals, 5758 S Maryland Avenue, MC 9006, Chicago, IL 60637, USA
    J Nucl Med 45:238-46. 2004
    ..The goal of this study was to evaluate the role of radioimmunoscintigraphy (RIS) directed against prostate-specific membrane antigen in modifying postprostatectomy prostate fossa clinical target volume (CTV) definition...
  89. pmc A study of the shielding used to reduce leakage and scattered radiation to the fetus in a pregnant patient treated with a 6-MV external X-ray beam
    Bin Han
    Nuclear Engineering and Engineering Physics, Rensselaer Polytechnic Institute, Troy, NY 12180, USA
    Health Phys 97:581-9. 2009
    ..The study demonstrates an accurate assessing tool that can be used to determine the absorbed dose to the fetus and to design the shielding as part of the treatment planning and risk management...
  90. ncbi Radiation therapy compared with chemotherapy for consolidation of chemotherapy-induced remission of advanced Hodgkin lymphoma: a study by the Eastern Co-operative Oncology Group (E1476) with >20 years follow-up
    Peter H Wiernik
    Montefiore Medical Center North Division, Cancer Center, New York Medical College, Bronx, NY 10466, USA
    Leuk Lymphoma 50:1632-41. 2009
    ..002). Treatment toxicity was acceptable. After MOPP-Bleo induction for advanced Hodgkin lymphoma, ABVD provides better consolidation than local RT...
  91. ncbi Evaluation of uncertainty predictions and dose output for model-based dose calculations for megavoltage photon beams
    Jörgen Olofsson
    Department of Radiation Sciences, Radiation Physics, Umea University, SE 901 87 Umea, Sweden
    Med Phys 33:2548-56. 2006
    ..A detailed analysis of the predicted uncertainties versus the observed deviations suggests that the predictions indeed can be used as a basis for creating action levels and tracking dose calculation errors in homogeneous media...
  92. ncbi Dosimetric evaluation of a 2D pixel ionization chamber for implementation in clinical routine
    J Herzen
    Department of Radiotherapy and Radio Oncology, Center for Diagnostic Imaging and Image Guided Therapy, Radiological Physics, University Medical Center Hamburg Eppendorf, Martinistrasse 52, DE 20251 Hamburg, Germany
    Phys Med Biol 52:1197-208. 2007
    ..From these investigations it can be concluded that the detector is a suitable device for quality assurance and 2D dose verifications...
  93. ncbi [Detection and prognostic significance of micrometastasis in peripheral blood of patients with non-small cell lung cancer treated by chemo-radiation therapy]
    Ting feng Chen
    Department of Radiation Oncology, Jiangsu Province Cancer Hospital Cancer Institute, Nanjing 210009, China
    Zhonghua Zhong Liu Za Zhi 29:365-8. 2007
    ..To investigate the prognostic significance of micrometastasis (MM) in peripheral blood of patients with non-small cell lung cancer (NSCLC) treated by chemo-radiation therapy...
  94. ncbi Management strategies for locally advanced prostate cancer
    Ashesh B Jani
    Department of Radiation and Cellular Oncology, University of Chicago Hospitals, Chicago, Illinois 60637, USA
    Drugs Aging 23:119-29. 2006
    ..Finally, novel investigational strategies such as chemotherapy and gene therapy are being applied in an attempt to improve outcomes of locally advanced prostate cancer patients...
  95. ncbi Modelling of output factors for conformal megavoltage X-ray beams
    A T Redpath
    Department of Oncology Physics, Western General Hospital, Crewe Road South, Edinburgh EH4 2XU, UK
    Br J Radiol 78:612-22. 2005
    ..The model has been incorporated into a computer program that is used clinically...
  96. ncbi The Schwarzschild effect of the dosimetry film Kodak EDR 2
    A Djouguela
    Pius Hospital Oldenburg, Clinic of Radiotherapy and Oncology, Medical Radiation Physics Working Group and University of Oldenburg, Oldenburg, Germany
    Phys Med Biol 50:N317-21. 2005
    ....
  97. ncbi Modeling skin collimation using the electron pencil beam redefinition algorithm
    Pai Chun M Chi
    Department of Radiation Physics, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA
    Med Phys 32:3409-18. 2005
    ..To further improve the accuracy of the PBRA in regions having significant electrons scattered from the edge of the skin collimation would require transporting the electrons through the lead skin collimation near its edges...
  98. ncbi Radiation therapy communication: equine hemangioma
    Miriam Kleiter
    Department for Companion Animals and Horses, Divisions of Internal Medicine and Infectious Diseases, University of Veterinary Medicine Vienna, Veterinaerplatz 1, 1210 Vienna, Austria
    Vet Radiol Ultrasound 50:560-3. 2009
    ..Wound healing by second intention was achieved over the next 4 months and the colt began race training 6 months after the end of therapy. Twenty months later the colt is sound and there is no evidence of tumor recurrence...
  99. ncbi A model to determine the initial phase space of a clinical electron beam from measured beam data
    J J Janssen
    Daniel den Hoed Cancer Center, University Hospital Rotterdam, The Netherlands
    Phys Med Biol 46:269-86. 2001
    ....
  100. ncbi The RBE of euoxic and hypoxic Ehrlich ascites tumour cells irradiated with negative pions in vitro and in vivo
    L Jüling-Pohlit
    Institute of Biophysics, University of Frankfurt, F R G
    Radiother Oncol 19:57-72. 1990
    ..Side effects in the mouse gut showed a RBE of 2.0, corresponding to irreparable lethal lesions in euoxic in vitro cells...
  101. ncbi Ionization chamber shift correction and surface dose measurements in electron beams
    I J Das
    Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Phys Med Biol 43:3419-24. 1998
    ..The method presented in this report is unambiguous, fast and reliable for the estimation of surface dose and the shift needed in electron beam dosimetry...

Research Grants19

  1. Radiotherapy Quality and Outcomes in Prostate Cancer
    JUSTIN BEKELMAN; Fiscal Year: 2006
    ..Furthermore, we hypothesize that higher radiotherapy quality performance is associated with longer event-free survival and lower morbidity. [unreadable] [unreadable] [unreadable]..
  2. Chemotherapy with injectable microdroplets
    FRANCESCO D ERRICO; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  3. Real-time in Vivo Dosimetry in Radiation Therapy Using Scintillation Detectors
    Sam Beddar; Fiscal Year: 2009
    ..The resulting data can also be used to study dose- related treatment side effects. The ultimate goal of utilizing this method is to improve the delivery of radiotherapy treatments and the quality of life of radiotherapy patients. ..
  4. Prediction of Second Cancer Risks for Children Treated with Proton - vs. - Photon
    Wayne D Newhauser; Fiscal Year: 2010
    ..In the future, we expect that the lower-risk treatments will result in fewer second cancers and this will translate into longer, higher-quality lives for survivors of childhood cancer (presently 270,000 persons in the United States). ..
  5. Real-Time PDT Dosimetry with Feedback Light Delivery
    Timothy Zhu; Fiscal Year: 2008
    ..abstract_text> ..
  6. Laser acceleration of protons for radiation therapy
    Dale Litzenberg; Fiscal Year: 2007
    ..This research will conduct the first critical step in determining if the cost can be dramatically reduced through the use of new acceleration technology. [unreadable] [unreadable] [unreadable]..
  7. Better correlation of outcomes with MC dose calculation
    Indrin Chetty; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  8. Multiattribute decision theory for IMRT plan selection
    Mark Phillips; Fiscal Year: 2009
    ..We will develop and evaluate influence diagrams for prostate cancer and for head &neck cancer. ..
  9. The Zebrafish Radioresponse for High-Throughput and -Content Molecular Screening
    Gary Kao; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  10. MINORITY BASED COMMUNITY CLINICAL ONCOLOGY PROGRAM
    Peter Wiernik; Fiscal Year: 2006
    ..Efforts in screening and prevention intervention will be facilitated through the Community Outreach program and Community Council. ..
  11. HDAC4 Viability: Unique Mechanisms and Function
    Gary Kao; Fiscal Year: 2007
    ..When aspects of this unique and vital feedback loop are interrupted, cellular death ensues. ..
  12. Regulation- Medulloblastoma Growth by alpha-v integrins
    Tobey Macdonald; Fiscal Year: 2006
    ..The long-range goal of this work is to broaden our understanding of medulloblastoma growth, so that novel biologic therapies may be developed into new treatments for medulloblastoma, the most common malignant brain tumor in children. ..
  13. Cancer Risks Attributable To Radiation from Pediatric CT
    David Brenner; Fiscal Year: 2006
    ..The target audiences will be radiologists, pediatricians, family physicians, and the CT industry. We will use telephone interviews supplemented with survey questions, to aid in web content decisions. ..
  14. Accelerated x-ray therapy planning system PEREGRINE
    PAUL NIZIN; Fiscal Year: 2004
    ..2. Benchmarking of NVR over the range of clinically useful energies in homogeneous and heterogeneous phantoms. 3. Validation of NVR in the case of patient-specific Monte Carlo calculations using CT based patient anatomy. ..
  15. INVESTIGATING THE MECHANISMS OF PRB TUMOR SUPPRESSION
    Arnab Chakravarti; Fiscal Year: 2003
    ..Specific Aim number 3: To determine whether the deregulation of E2F dependent transcription is correlated with the tumorigenic potential of RB -/- cells in-vivo. ..
  16. High Stability Accelerator for Sub-Cellular Microbeam
    David Brenner; Fiscal Year: 2003
    ..We have considerably more demand for microbeam time than we can cope with, primarily because of limited physicist manpower. ..
  17. RADIOLOGICAL RESEARCH ACCELERATOR FACILITY (RARAF)
    David Brenner; Fiscal Year: 2002
    ..abstract_text> ..
  18. HIGH ENERGY IONS AND GENOMIC INSTABILITY
    Eric Hall; Fiscal Year: 2001
    ....