cranial irradiation

Summary

Summary: The exposure of the head to roentgen rays or other forms of radioactivity for therapeutic or preventive purposes.

Top Publications

  1. ncbi Neurocognition in patients with brain metastases treated with radiosurgery or radiosurgery plus whole-brain irradiation: a randomised controlled trial
    Eric L Chang
    Department of Radiation Oncology, The University of Texas, M D Anderson Cancer Center, Houston, TX, USA
    Lancet Oncol 10:1037-44. 2009
  2. ncbi Stereotactic radiosurgery plus whole-brain radiation therapy vs stereotactic radiosurgery alone for treatment of brain metastases: a randomized controlled trial
    Hidefumi Aoyama
    Departments of Radiology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    JAMA 295:2483-91. 2006
  3. ncbi Prophylactic cranial irradiation in extensive small-cell lung cancer
    Ben Slotman
    Department of Radiation Oncology, VU University Medical Center, Amsterdam, The Netherlands
    N Engl J Med 357:664-72. 2007
  4. ncbi A practical technique to avoid the hippocampus in prophylactic cranial irradiation for lung cancer
    Zdenko van Kesteren
    Department of Radiation Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
    Radiother Oncol 102:225-7. 2012
  5. ncbi Radiosurgery for patients with brain metastases: a multi-institutional analysis, stratified by the RTOG recursive partitioning analysis method
    S N Sanghavi
    University of Wisconsin, Madison, WI 53792, USA
    Int J Radiat Oncol Biol Phys 51:426-34. 2001
  6. pmc Cranial irradiation alters the behaviorally induced immediate-early gene arc (activity-regulated cytoskeleton-associated protein)
    Susanna Rosi
    Brain and Spinal Injury Center, Department of Physical Therapy and Rehabilitation Sciences, University of California, San Francisco, San Francisco, California 94110, USA
    Cancer Res 68:9763-70. 2008
  7. ncbi Neurocognitive outcome in brain metastases patients treated with accelerated-fractionation vs. accelerated-hyperfractionated radiotherapy: an analysis from Radiation Therapy Oncology Group Study 91-04
    W F Regine
    University of Kentucky, Department of Radiation, Lexington, KY, USA
    Int J Radiat Oncol Biol Phys 51:711-7. 2001
  8. ncbi A multi-institutional review of radiosurgery alone vs. radiosurgery with whole brain radiotherapy as the initial management of brain metastases
    Penny K Sneed
    Department of Radiation Oncology, University of California San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143 0226, USA
    Int J Radiat Oncol Biol Phys 53:519-26. 2002
  9. ncbi The American Society for Therapeutic Radiology and Oncology (ASTRO) evidence-based review of the role of radiosurgery for brain metastases
    Minesh P Mehta
    The American Society for Therapeutic Radiology and Oncology, Fairfax, VA 22033, USA
    Int J Radiat Oncol Biol Phys 63:37-46. 2005
  10. ncbi Early compared with late radiotherapy in combined modality treatment for limited disease small-cell lung cancer: a London Lung Cancer Group multicenter randomized clinical trial and meta-analysis
    Stephen G Spiro
    University College Hospitals Trust, London, United Kingdom
    J Clin Oncol 24:3823-30. 2006

Detail Information

Publications256 found, 100 shown here

  1. ncbi Neurocognition in patients with brain metastases treated with radiosurgery or radiosurgery plus whole-brain irradiation: a randomised controlled trial
    Eric L Chang
    Department of Radiation Oncology, The University of Texas, M D Anderson Cancer Center, Houston, TX, USA
    Lancet Oncol 10:1037-44. 2009
    ..We proposed that the learning and memory functions of patients who undergo SRS plus WBRT are worse than those of patients who undergo SRS alone. We did a randomised controlled trial to test our prediction...
  2. ncbi Stereotactic radiosurgery plus whole-brain radiation therapy vs stereotactic radiosurgery alone for treatment of brain metastases: a randomized controlled trial
    Hidefumi Aoyama
    Departments of Radiology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    JAMA 295:2483-91. 2006
    ..In patients with brain metastases, it is unclear whether adding up-front whole-brain radiation therapy (WBRT) to stereotactic radiosurgery (SRS) has beneficial effects on mortality or neurologic function compared with SRS alone...
  3. ncbi Prophylactic cranial irradiation in extensive small-cell lung cancer
    Ben Slotman
    Department of Radiation Oncology, VU University Medical Center, Amsterdam, The Netherlands
    N Engl J Med 357:664-72. 2007
    We conducted a randomized trial of prophylactic cranial irradiation in patients with extensive small-cell lung cancer who had had a response to chemotherapy.
  4. ncbi A practical technique to avoid the hippocampus in prophylactic cranial irradiation for lung cancer
    Zdenko van Kesteren
    Department of Radiation Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
    Radiother Oncol 102:225-7. 2012
    A practical technique is presented to deliver hippocampus avoiding prophylactic cranial irradiation for lung cancer patients, using two lateral fields. For a prescribed dose of 12×2.5 Gy, sparing of the hippocampi to 6...
  5. ncbi Radiosurgery for patients with brain metastases: a multi-institutional analysis, stratified by the RTOG recursive partitioning analysis method
    S N Sanghavi
    University of Wisconsin, Madison, WI 53792, USA
    Int J Radiat Oncol Biol Phys 51:426-34. 2001
    ..CONCLUSION: In the absence of randomized data, these results suggest that RS may improve survival in patients with BM. The improvement in survival does not appear to be restricted by class for well-selected patients...
  6. pmc Cranial irradiation alters the behaviorally induced immediate-early gene arc (activity-regulated cytoskeleton-associated protein)
    Susanna Rosi
    Brain and Spinal Injury Center, Department of Physical Therapy and Rehabilitation Sciences, University of California, San Francisco, San Francisco, California 94110, USA
    Cancer Res 68:9763-70. 2008
    ..These findings are the first to show that local brain irradiation initiates changes in hippocampal neurons that disrupt the activity patterns (Arc expression) associated with neuroplasticity and memory...
  7. ncbi Neurocognitive outcome in brain metastases patients treated with accelerated-fractionation vs. accelerated-hyperfractionated radiotherapy: an analysis from Radiation Therapy Oncology Group Study 91-04
    W F Regine
    University of Kentucky, Department of Radiation, Lexington, KY, USA
    Int J Radiat Oncol Biol Phys 51:711-7. 2001
    ..accelerated hyperfractionated (AH) whole-brain radiation therapy (WBRT)...
  8. ncbi A multi-institutional review of radiosurgery alone vs. radiosurgery with whole brain radiotherapy as the initial management of brain metastases
    Penny K Sneed
    Department of Radiation Oncology, University of California San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143 0226, USA
    Int J Radiat Oncol Biol Phys 53:519-26. 2002
    ..Data collected from 10 institutions were reviewed to compare survival probabilities of patients with newly diagnosed brain metastases managed initially with radiosurgery (RS) alone vs. RS + whole brain radiotherapy (WBRT)...
  9. ncbi The American Society for Therapeutic Radiology and Oncology (ASTRO) evidence-based review of the role of radiosurgery for brain metastases
    Minesh P Mehta
    The American Society for Therapeutic Radiology and Oncology, Fairfax, VA 22033, USA
    Int J Radiat Oncol Biol Phys 63:37-46. 2005
    ..To systematically review the evidence for the use of stereotactic radiosurgery in adult patients with brain metastases...
  10. ncbi Early compared with late radiotherapy in combined modality treatment for limited disease small-cell lung cancer: a London Lung Cancer Group multicenter randomized clinical trial and meta-analysis
    Stephen G Spiro
    University College Hospitals Trust, London, United Kingdom
    J Clin Oncol 24:3823-30. 2006
    ..To replicate an earlier National Cancer Institute of Canada (NCIC) trial that examined the effect on survival of the timing of thoracic radiotherapy (TRT) in patients with limited disease small-cell lung cancer (SCLC)...
  11. pmc Prophylactic cranial irradiation in small-cell lung cancer: findings from a North Central Cancer Treatment Group Pooled Analysis
    S E Schild
    Department of Radiation Oncology, Mayo Clinic, Scottsdale, USA
    Ann Oncol 23:2919-24. 2012
    This pooled analysis evaluated the outcomes of prophylactic cranial irradiation (PCI) in 739 small-cell lung cancer (SCLC patients with stable disease (SD) or better following chemotherapy ± thoracic radiation therapy (TRT) to examine ..
  12. ncbi Phase I trial of simultaneous in-field boost with helical tomotherapy for patients with one to three brain metastases
    George Rodrigues
    Department of Oncology, University of Western Ontario and London Regional Cancer Program, London Health Sciences Centre, London, ON, Canada
    Int J Radiat Oncol Biol Phys 80:1128-33. 2011
    ..The present study's objective was to determine the maximally tolerated dose of a simultaneous in-field boost integrated with whole brain radiotherapy for palliative treatment of patients with one to three brain metastases using HT...
  13. pmc Why avoid the hippocampus? A comprehensive review
    Vinai Gondi
    Department of Human Oncology, University of Wisconsin Comprehensive Cancer Center, Madison, WI 53792, USA
    Radiother Oncol 97:370-6. 2010
    ..of the rationale for using modern IMRT techniques to spare the subgranular zone of the hippocampus during cranial irradiation. We review the literature on neurocognitive effects of cranial irradiation; discuss clinical and ..
  14. pmc Estimated risk of perihippocampal disease progression after hippocampal avoidance during whole-brain radiotherapy: safety profile for RTOG 0933
    Vinai Gondi
    Department of Human Oncology, University of Wisconsin Comprehensive Cancer Center, Madison, WI 53792, USA
    Radiother Oncol 95:327-31. 2010
    ..By quantifying baseline incidence of perihippocampal or hippocampal metastasis, we sought to estimate the risk of developing metastases in the hippocampal avoidance region (the hippocampus plus 5mm margin)...
  15. ncbi Outcome, quality of life and cognitive function of patients with brain metastases from non-small cell lung cancer treated with whole brain radiotherapy combined with gefitinib or temozolomide. A randomised phase II trial of the Swiss Group for Clinical Ca
    Gianfranco A Pesce
    Istituto Oncologico della Svizzera Italiana, Bellinzona, Switzerland
    Eur J Cancer 48:377-84. 2012
    ..Patients with brain metastases (BM) rarely survive longer than 6months and are commonly excluded from clinical trials. We explored two combined modality regimens with novel agents with single agent activity and radiosensitizing properties...
  16. pmc Phase III trial of prophylactic cranial irradiation compared with observation in patients with locally advanced non-small-cell lung cancer: neurocognitive and quality-of-life analysis
    Alexander Sun
    Princess Margaret Hospital University Health Network, University of Toronto, 610 University Ave, Toronto, Ontario, Canada, M5G 2M9
    J Clin Oncol 29:279-86. 2011
    There are scant data regarding the effects of prophylactic cranial irradiation (PCI) on neurocognitive function (NCF) and quality of life (QOL)...
  17. ncbi Lithium treatment prevents neurocognitive deficit resulting from cranial irradiation
    Eugenia M Yazlovitskaya
    Department of Radiation Oncology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 5671, USA
    Cancer Res 66:11179-86. 2006
    Curative cancer treatment regimens often require cranial irradiation, resulting in lifelong neurocognitive deficiency in cancer survivors...
  18. ncbi Management of brain metastases: the indispensable role of surgery
    George Al-Shamy
    Department of Neurosurgery, Baylor College of Medicine and The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    J Neurooncol 92:275-82. 2009
    ..Achieving the best outcome in treatment of brain metastasis requires the judicious and complementary use of surgical resection along with modalities such as whole-brain radiation therapy and stereotactic radiosurgery...
  19. ncbi Stereotactic radiosurgery with or without whole brain radiotherapy for patients with a single radioresistant brain metastasis
    James W Clarke
    Department of Radiation Medicine, The Ohio State University Arthur G James Cancer Hospital, Columbus, Ohio 43210, USA
    Am J Clin Oncol 33:70-4. 2010
    ..To examine the outcomes of patients with a single brain metastasis from radioresistant histologies (renal cell carcinoma and melanoma) treated with stereotactic radiosurgery (SRS) with or without whole brain radiotherapy (WBRT)...
  20. ncbi Neurocognitive function of patients with brain metastasis who received either whole brain radiotherapy plus stereotactic radiosurgery or radiosurgery alone
    Hidefumi Aoyama
    Department of Radiology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Int J Radiat Oncol Biol Phys 68:1388-95. 2007
    ..To determine how the omission of whole brain radiotherapy (WBRT) affects the neurocognitive function of patients with one to four brain metastases who have been treated with stereotactic radiosurgery (SRS)...
  21. ncbi Late-occurring stroke among long-term survivors of childhood leukemia and brain tumors: a report from the Childhood Cancer Survivor Study
    Daniel C Bowers
    Department of Pediatrics, The University of Texas Southwestern Medical School, Dallas, TX 75390 9063, USA
    J Clin Oncol 24:5277-82. 2006
    ..This report examines the incidence of and risk factors for strokes that occur in > or = 5-year survivors of childhood leukemia and brain tumors...
  22. ncbi Hypofractionated stereotactic radiotherapy for brain metastases--results from three different dose concepts
    Antje Fahrig
    Department of Radiation Therapy and Novalis Shaped Beam Surgery Center of the University of Erlangen, Erlangen, Germany
    Strahlenther Onkol 183:625-30. 2007
    ..To evaluate efficacy and toxicity of hypofractionated stereotactic radiotherapy (hfSRT) with three different dose concepts for irresectable brain metastases not amenable to radiosurgery (SRS) using non-invasive fixation of the skull...
  23. pmc Cranial irradiation compromises neuronal architecture in the hippocampus
    Vipan Kumar Parihar
    Department of Radiation Oncology, University of California, Irvine, CA 92697 2695, USA
    Proc Natl Acad Sci U S A 110:12822-7. 2013
    b>Cranial irradiation is used routinely for the treatment of nearly all brain tumors, but may lead to progressive and debilitating impairments of cognitive function...
  24. ncbi Hypofractionated stereotactic radiotherapy in combination with whole brain radiotherapy for brain metastases
    Cesare Giubilei
    Department of Diagnostic Imaging, Tor Vergata University General Hospital, 00133, Rome, Italy
    J Neurooncol 91:207-12. 2009
    ..The efficacy and toxicity of hypofractionated stereotactic radiotherapy (HSRT) in combination with whole brain radiotherapy (WBRT), for the treatment of 1-4 brain metastases, using a non invasive fixation of the skull, was investigated...
  25. ncbi Reduction of adult height in childhood acute lymphoblastic leukemia survivors after prophylactic cranial irradiation
    M E J Bongers
    Department of Pediatrics, Division of Pediatric Oncology, University of Groningen University Hospital Groningen, The Netherlands
    Pediatr Blood Cancer 45:139-43. 2005
    Impaired linear growth is a well-recognized complication in long-term childhood ALL survivors who received cranial irradiation. However, as many patients achieve a final height between the 5th and the 95th centile, the true incidence of ..
  26. ncbi Prevention and treatment of the consequences of head and neck radiotherapy
    A Vissink
    Department of Oral and Maxillofacial Surgery, University Hospital, PO Box 30 001, 9700 RB Groningen, The Netherlands
    Crit Rev Oral Biol Med 14:213-25. 2003
    ..In this review, the various possibilities for prevention and/or treatment of radiation-induced changes in healthy oral tissues and their consequences are discussed...
  27. ncbi Evaluation of the use of prophylactic cranial irradiation in small cell lung cancer
    Shilpen Patel
    Department of Radiation Oncology, University of Washington, Seattle, Washington 98195 6043, USA
    Cancer 115:842-50. 2009
    Prophylactic cranial irradiation has been used in patients with small cell lung cancer to reduce the incidence of brain metastasis after primary therapy...
  28. pmc High-resolution in-vivo analysis of normal brain response to cranial irradiation
    Kelly Burrell
    Brain Tumor Research Centre, SickKids Research Institute, Toronto, Canada
    PLoS ONE 7:e38366. 2012
    ..However, despite recognized therapeutic success, significant negative consequences are associated with cranial irradiation (CR), which manifests months to years post-RT...
  29. ncbi Hypofractionated frameless stereotactic intensity-modulated radiotherapy with whole brain radiotherapy for the treatment of 1-3 brain metastases
    Bruno De Potter
    Department of Radiotherapy, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium
    Neurol Sci 34:647-53. 2013
    ..The 1-year actuarial local and distant brain control was 66 and 75 %, respectively. WBRT + HSRT is an effective treatment for patients with up to three brain metastases...
  30. pmc CCR2 deficiency prevents neuronal dysfunction and cognitive impairments induced by cranial irradiation
    Karim Belarbi
    Brain and Spinal Injury Center, University of California, San Francisco, San Francisco, CA 94110, USA
    Cancer Res 73:1201-10. 2013
    b>Cranial irradiation can lead to long-lasting cognitive impairments in patients receiving radiotherapy for the treatment of malignant brain tumors...
  31. pmc Risk factors for intellectual and educational sequelae of cranial irradiation in childhood acute lymphoblastic leukaemia
    E Smibert
    Department of Clinical Haematology and Oncology, Royal Children s Hospital, Melbourne, Australia
    Br J Cancer 73:825-30. 1996
    Long-term cognitive and educational sequelae have been inconsistently reported in children who received cranial irradiation (CRT) to prevent central nervous system (CNS) disease in acute lymphoblastic leukaemia (ALL)...
  32. ncbi Standard-dose versus higher-dose prophylactic cranial irradiation (PCI) in patients with limited-stage small-cell lung cancer in complete remission after chemotherapy and thoracic radiotherapy (PCI 99-01, EORTC 22003-08004, RTOG 0212, and IFCT 99-01): a r
    Cécile Le Péchoux
    Radiotherapy Department, Institut Gustave Roussy, Villejuif, France
    Lancet Oncol 10:467-74. 2009
    The optimum dose of prophylactic cranial irradiation (PCI) for limited-stage small-cell lung cancer (SCLC) is unknown. A meta-analysis suggested that the incidence of brain metastases might be reduced with higher PCI doses...
  33. ncbi Hypofractionated stereotactic radiotherapy for the treatment of brain metastases
    Alexander K Kwon
    Department of Radiation Oncology, Cooper University Hospital, Camden, New Jersey, USA
    Cancer 115:890-8. 2009
    ..This retrospective review evaluated the efficacy and toxicity profiles of various dose fractionations using hypofractionated stereotactic radiotherapy (HSRT) in the treatment of brain metastases...
  34. ncbi Neurocognitive function in patients with small cell lung cancer : effect of prophylactic cranial irradiation
    David R Grosshans
    Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 112:589-95. 2008
    The use of prophylactic cranial irradiation (PCI) in patients with small cell lung cancer (SCLC) has been tempered by fears of detrimental effects on cognitive function...
  35. ncbi Stereotatic radiosurgery of 468 brain metastases < or =2 cm: implications for SRS dose and whole brain radiation therapy
    Michael K Shehata
    Department of Radiation Medicine, University of Kentucky, Lexington, KY, USA
    Int J Radiat Oncol Biol Phys 59:87-93. 2004
    ..On the basis of our institutional experience, the goal of this study was to determine the optimal SRS dose and influence of WBRT on local tumor control among 468 < or =2-cm metastases...
  36. ncbi The role of whole brain radiation therapy for the management of brain metastases in the era of stereotactic radiosurgery
    Eisuke Abe
    Division of Radiation Oncology, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Chuo Ku, Niigata, 951 8510, Japan
    Curr Oncol Rep 14:79-84. 2012
    ..Patients who have solitary BM with the absence of extracranial metastases may be indicated for SRS monotherapy given the lower risk of BTR compared with those having multiple BMs or extracranial metastases...
  37. ncbi Relationship between neurocognitive function and quality of life after whole-brain radiotherapy in patients with brain metastasis
    Jing Li
    Department of Human Oncology, University of Wisconsin Comprehensive Cancer Center, Madison, WI 53792, USA
    Int J Radiat Oncol Biol Phys 71:64-70. 2008
    ..To examine the relationship between neurocognitive function (NCF) and quality of life (QOL) in patients with brain metastases after whole-brain radiotherapy...
  38. ncbi Outcome of moderately dosed radiosurgery for limited brain metastases. Report of a single-center experience
    Johanna Meisner
    Department of Radiation Oncology, Medical School Hannover, Carl Neuberg Strasse 1, Hannover, Germany
    Strahlenther Onkol 186:76-81. 2010
    ..Efficacy and safety of the own single-center experience with moderately dosed radiosurgery (SRS) for limited (one to four) brain metastases were analyzed and correlated with patient- and treatment-related variables...
  39. ncbi Management of nonsinonasal neuroendocrine carcinomas of the head and neck
    Jerry L Barker
    Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 98:2322-8. 2003
    ..The authors undertook a retrospective study to gain insights into the spectrum of clinicopathologic characteristics, patterns of failure, and optimal management of patients with this disease...
  40. ncbi Microsurgery plus whole brain irradiation versus Gamma Knife surgery alone for treatment of single metastases to the brain: a randomized controlled multicentre phase III trial
    Alexander Muacevic
    Department of Neurosurgery, Ludwig Maximilians University, Klinikum Grosshadern, Munich 81377, Germany
    J Neurooncol 87:299-307. 2008
    ..Is Gamma Knife surgery alone as effective as surgery plus whole brain irradiation (WBRT) for patients with a single, small-sized brain metastasis?..
  41. pmc Prophylactic cranial irradiation in small cell lung cancer: a systematic review of the literature with meta-analysis
    A P Meert
    Service de Medecine, Institut Jules Bordet, Bruxelles, Belgique
    BMC Cancer 1:5. 2001
    A systematic review of the literature was carried out to determine the role of prophylactic cranial irradiation (PCI) in small cell lung cancer (SCLC).
  42. pmc Phase III comparison of prophylactic cranial irradiation versus observation in patients with locally advanced non-small-cell lung cancer: primary analysis of radiation therapy oncology group study RTOG 0214
    Elizabeth M Gore
    Department of Radiation Oncology, Medical College of Wisconsin, 9200 W Wisconsin Ave, Milwaukee, WI 53213, USA
    J Clin Oncol 29:272-8. 2011
    This study was conducted to determine if prophylactic cranial irradiation (PCI) improves survival in locally advanced non-small-cell lung cancer (LA-NSCLC).
  43. ncbi Improved outcome for children with acute lymphoblastic leukemia: results of Total Therapy Study XIIIB at St Jude Children's Research Hospital
    Ching Hon Pui
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    Blood 104:2690-6. 2004
    ..b>Cranial irradiation was reserved for the 12% of patients who had T-cell ALL and a presenting leukocyte count of 100 x 10(9)/L ..
  44. ncbi Whole-brain radiotherapy in the management of brain metastasis
    Deepak Khuntia
    University of Wisconsin, Madison, WI 53792, USA
    J Clin Oncol 24:1295-304. 2006
    ..In this review article, we present the standard treatment approach of whole-brain radiotherapy and discuss new directions, including the role of chemical modifiers and the management and prevention of neurocognitive deficits...
  45. pmc Cognitive and academic outcome following cranial irradiation and chemotherapy in children: a longitudinal study
    V A Anderson
    Dept Psychology, University of Melbourne, Parkville, Victoria, Australia
    Br J Cancer 82:255-62. 2000
    b>Cranial irradiation therapy (CRT) and chemotherapy are associated with neurobehavioural deficits. Many studies have investigated late effects of these treatments, but few have evaluated changes in abilities over time...
  46. ncbi Height and weight in children treated for acute lymphoblastic leukemia: relationship to CNS treatment
    Virginia Kimball Dalton
    Department of Medicine, Children s Hospital, Boston, MA 02115, USA
    J Clin Oncol 21:2953-60. 2003
    ....
  47. pmc Cranial irradiation alters dendritic spine density and morphology in the hippocampus
    Ayanabha Chakraborti
    Department of Neurological Surgery, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 7:e40844. 2012
    ..cellular changes in the hippocampus following brain irradiation, we investigated the effects of 10 Gy cranial irradiation on dendritic spines in young adult mice...
  48. ncbi Reducing toxicity from craniospinal irradiation: using proton beams to treat medulloblastoma in young children
    Grace E Yuh
    Department of Radiation Medicine, Loma Linda University Medical Center, Loma Linda, California 92354, USA
    Cancer J 10:386-90. 2004
    ..We report on a radiation treatment technique that has reduced the dose to critical normal structures in children with medulloblastoma...
  49. ncbi A randomised phase III study of palliative radiation with concomitant carboplatin for brain metastases from non-small cell carcinoma of the lung
    Mario Guerrieri
    Division of Radiation Oncology, Besen Family Department of Radiation, Peter MacCallum Cancer Centre, St Andrews Place, Locked Bag 1, A Beckett Street, East Melbourne, Victoria 8006, Australia
    Lung Cancer 46:107-11. 2004
    ..To determine if the addition of carboplatin chemotherapy to whole brain irradiation improves response and survival in patients with brain metastases from non-small cell lung cancer (NSCLC)...
  50. ncbi Small cell lung cancer
    G Rosti
    Medical Oncology, Ravenna, Italy
    Ann Oncol 17:ii5-10. 2006
    ..Targeted therapies are undergoing some evaluations, but the data are too premature and so far quite discouraging. At the present time there is a urgent need to improve clinical research in this somehow forgotten disease...
  51. ncbi Unintended effects of cranial irradiation on cognitive function
    Jacob Raber
    Department of Behavioral Neuroscience, and Division of Neuroscience, ONPRC, Oregon Health and Science University, Portland, Oregon 97239, USA
    Toxicol Pathol 38:198-202. 2010
    ..The symposium was held in Washington, DC, in 2009 and dealt with unintended adverse events associated with cranial irradiation as part of cancer therapy...
  52. ncbi Gamma-knife radiosurgery as an optimal treatment modality for brain metastases from epithelial ovarian cancer
    Yoo Kyung Lee
    Department of Obstetrics and Gynecology, Seoul National University Hospital, Seoul, Korea
    Gynecol Oncol 108:505-9. 2008
    ....
  53. ncbi Survival by radiation therapy oncology group recursive partitioning analysis class and treatment modality in patients with brain metastases from malignant melanoma: a retrospective study
    Jeffrey C Buchsbaum
    Department of Radiation Oncology, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Cancer 94:2265-72. 2002
    ....
  54. ncbi Dose escalation of whole-brain radiotherapy for brain metastases from melanoma
    Dirk Rades
    Department of Radiation Oncology, University Hospital Schleswig Holstein, Lubeck, Germany
    Int J Radiat Oncol Biol Phys 77:537-41. 2010
    ..Hypofractionation regimens failed to improve the outcome of these patients. This study investigates a potential benefit from escalation of the WBRT dose beyond the "standard" regimen 30 Gy in 10 fractions (10x3 Gy)...
  55. ncbi Lead-in phase to randomized trial of motexafin gadolinium and whole-brain radiation for patients with brain metastases: centralized assessment of magnetic resonance imaging, neurocognitive, and neurologic end points
    Minesh P Mehta
    Department of Human Oncology, Medical School, University of Wisconsin Madison, K4 334 Clinical Science Center, 600 Highland Avenue, Madison, WI 53792, USA
    J Clin Oncol 20:3445-53. 2002
    ....
  56. pmc Prophylactic cranial irradiation in extensive disease small-cell lung cancer: short-term health-related quality of life and patient reported symptoms: results of an international Phase III randomized controlled trial by the EORTC Radiation Oncology and Lu
    Berend J Slotman
    Department of Radiation Oncology, VU University Medical Center, Amsterdam, The Netherlands
    J Clin Oncol 27:78-84. 2009
    Prophylactic cranial irradiation (PCI) in patients with extensive-disease small-cell lung cancer (ED-SCLC) leads to significantly fewer symptomatic brain metastases and improved survival...
  57. ncbi DEGRO Practical Guidelines for palliative radiotherapy of breast cancer patients: brain metastases and leptomeningeal carcinomatosis
    Petra Feyer
    Klinikum Neukölln, Berlin, Germany
    Strahlenther Onkol 186:63-9. 2010
    ..To provide recommendations for palliative treatment of brain metastases (BM) and leptomeningeal carcinomatosis (LC) in breast cancer patients with specific emphasis on radiooncologic aspects...
  58. ncbi Hypothalamic-pituitary-ovarian dysfunction after prepubertal chemotherapy and cranial irradiation for acute leukaemia
    L E Bath
    Section of Child Life and Health, Department of Reproductive and Developmental Sciences, University of Edinburgh, UK
    Hum Reprod 16:1838-44. 2001
    ..We assessed adult hypothalamic-pituitary-ovarian function following treatment with chemotherapy and cranial irradiation for childhood acute lymphoblastic leukaemia...
  59. ncbi Diagnostic cerebrospinal fluid examination in children with acute lymphoblastic leukemia: significance of low leukocyte counts with blasts or traumatic lumbar puncture
    Britta Bürger
    Department of Pediatric Hematology Oncology, Hannover Medical School, Hannover, Germany
    J Clin Oncol 21:184-8. 2003
    ..To determine the significance of leukemic blasts or traumatic lumbar puncture (TLP) in diagnostic CSF of children enrolled in the Berlin-Frankfurt-Münster (BFM) Acute Lymphoblastic Leukemia-BFM-95 trial...
  60. ncbi Neurocognitive function and progression in patients with brain metastases treated with whole-brain radiation and motexafin gadolinium: results of a randomized phase III trial
    Christina A Meyers
    Department of Neuro Oncology, Unit 431, M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    J Clin Oncol 22:157-65. 2004
    ....
  61. ncbi Radiotherapeutic management of brain metastases: a systematic review and meta-analysis
    May N Tsao
    Department of Radiation Oncology, Toronto Sunnybrook Regional Cancer Centre, 2075 Bayview Avenue, Toronto, Ont, Canada M4N 3M5
    Cancer Treat Rev 31:256-73. 2005
    ..The management of brain metastases is a significant health care problem. An estimated 20-40% of cancer patients will develop metastatic cancer to the brain during the course of their illness...
  62. ncbi Brain metastases in patients with breast cancer: new horizons
    David G Kirsch
    Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Clin Breast Cancer 6:115-24. 2005
    ..Given the prevalence of brain metastases in patients with metastatic breast cancer in contemporary series, the rationale for clinical trials of CNS screening and prophylactic cranial irradiation will be discussed.
  63. pmc Auxological changes in UK survivors of childhood acute lymphoblastic leukaemia treated without cranial irradiation
    R A L Breene
    Department of Paediatric Haematology and Oncology, Addenbrooke s Hospital, Cambridge, CB2 0QQ, UK
    Br J Cancer 104:746-9. 2011
    ..Acute lymphoblastic leukaemia survivors treated historically with protocols including cranial irradiation demonstrate increased weight gain.
  64. ncbi Concurrent chemotherapy and reduced-dose cranial spinal irradiation followed by conformal posterior fossa tumor bed boost for average-risk medulloblastoma: efficacy and patterns of failure
    James G Douglas
    Department of Radiation Oncology, University of Washington School of Medicine, Seattle, WA 98195, USA
    Int J Radiat Oncol Biol Phys 58:1161-4. 2004
    ..To review the efficacy and patterns of failure in average-risk medulloblastoma patients treated with concurrent chemotherapy and reduced-dose cranial spinal irradiation and a conformal tumor bed boost...
  65. ncbi Hypofractionated conformal stereotactic radiotherapy alone or in combination with whole-brain radiotherapy in patients with cerebral metastases
    Peter Lindvall
    Department of Neurosurgery, University Hospital, Umea, Sweden
    Int J Radiat Oncol Biol Phys 61:1460-6. 2005
    ..The aim was to evaluate treatment of cerebral metastases with hypofractionated conformal stereotactic radiotherapy (HCSRT) or whole-brain radiotherapy (WBRT) in combination with a stereotactic boost...
  66. ncbi Patterns of failure after prophylactic cranial irradiation in small-cell lung cancer: analysis of 505 randomized patients
    R Arriagada
    Institut Gustave Roussy, Villejuif, France
    Ann Oncol 13:748-54. 2002
    Prophylactic cranial irradiation (PCI) has a beneficial effect on overall survival in patients with small-cell lung cancer (SCLC) in complete remission as shown in a worldwide meta-analysis...
  67. pmc Primary analysis of a phase II randomized trial Radiation Therapy Oncology Group (RTOG) 0212: impact of different total doses and schedules of prophylactic cranial irradiation on chronic neurotoxicity and quality of life for patients with limited-disease
    Aaron H Wolfson
    Department of Radiation Oncology, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Int J Radiat Oncol Biol Phys 81:77-84. 2011
    To determine the effect of dose and fractionation schedule of prophylactic cranial irradiation (PCI) on the incidence of chronic neurotoxicity (CNt) and changes in quality of life for selected patients with limited-disease small-cell ..
  68. ncbi Allogeneic hematopoietic cell transplantation in children with relapsed acute lymphoblastic leukemia isolated to the central nervous system
    Paul D Harker-Murray
    Pediatric Blood and Marrow Transplant Program, University of Minnesota, Minneapolis, Minnesota, USA
    Biol Blood Marrow Transplant 14:685-92. 2008
    ..These data support the use of allogeneic HCT in the treatment of children with poor prognosis isolated CNS relapse...
  69. ncbi Permanent alopecia after cranial irradiation: dose-response relationship
    Brian D Lawenda
    Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, 100 Blossom Street, Boston, MA 02114, USA
    Int J Radiat Oncol Biol Phys 60:879-87. 2004
    To develop a dose-response relationship for the occurrence of permanent alopecia after cranial irradiation and to analyze potential confounding variables that may contribute to this unwanted and often unavoidable complication of treatment.
  70. ncbi Field-in-field technique with intrafractionally modulated junction shifts for craniospinal irradiation
    Sue S Yom
    Division of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Int J Radiat Oncol Biol Phys 69:1193-8. 2007
    ..To plan craniospinal irradiation with "field-in-field" (FIF) homogenization in combination with daily, intrafractional modulation of the field junctions, to minimize the possibility of spinal cord overdose...
  71. pmc Insulin resistance and risk factors for cardiovascular disease in young adult survivors of childhood acute lymphoblastic leukemia
    Kevin C Oeffinger
    Department of Pediatrics, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10021, USA
    J Clin Oncol 27:3698-704. 2009
    ..To determine the prevalence of insulin resistance and other risk factors for cardiovascular disease (CVD) in young adult survivors of childhood acute lymphoblastic leukemia (ALL)...
  72. ncbi Leptin assessment in acute lymphocytic leukemia survivors: role of cranial radiotherapy?
    Adriana Aparecida Siviero-Miachon
    Division of Pediatric Endocrinology, Department of Pediatrics, Federal University of Sao Paulo UNIFESP EPM, Brazil
    J Pediatr Hematol Oncol 29:776-82. 2007
    ..index (BMI) in a sample of 26 acute lymphocytic leukemia survivors of both sexes, treated with and without cranial irradiation, aged 7.6 to 17 years, at a mean 3.4+/-2.0 years off treatment...
  73. pmc Attentional ability among survivors of leukaemia treated without cranial irradiation
    J Rodgers
    Doctorate in Clinical Psychology, University of Newcastle, UK
    Arch Dis Child 88:147-50. 2003
    Previous research has indicated that children who have received treatment for leukaemia which includes cranial irradiation exhibit deficits in their ability to focus attention...
  74. ncbi Long-term results of prophylactic cranial irradiation for limited-stage small-cell lung cancer in complete remission
    Ka Jia Cao
    Department of Radiation Oncology, Cancer Centre, Sun Yat Sen University, Guangzhou 510060, China
    Chin Med J (Engl) 118:1258-62. 2005
    ..This study was conducted to evaluate the effects of prophylactic cranial irradiation (PCI) on survival and brain metastases for patients with limited stage small cell lung cancer in complete ..
  75. ncbi Radiation-induced meningiomas after high-dose cranial irradiation
    Bartosz Godlewski
    Department of Neurosurgery and Peripheral Nerves Surgery, WAM University Hospital in Lodz, Medical University in Lodz, 113 Zeromskiego Street, Lodz 90 549, Poland
    J Clin Neurosci 19:1627-35. 2012
    ..It is timely to consider RIM due to high dose radiation, which is now frequently employed in the management of various childhood and other malignancies...
  76. ncbi Longitudinal linear growth and final height is impaired in childhood acute lymphoblastic leukemia survivors after treatment without cranial irradiation
    Els Vandecruys
    Department of Pediatric Hemato Oncology, Ghent University Hospital, Ghent, Belgium
    J Pediatr 163:268-73. 2013
    ....
  77. ncbi Factors affecting the risk of brain metastasis in small cell lung cancer with surgery: is prophylactic cranial irradiation necessary for stage I-III disease?
    Linlin Gong
    Department of Radiotherapy, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China
    Int J Radiat Oncol Biol Phys 85:196-200. 2013
    The use of prophylactic cranial irradiation (PCI) in small cell lung cancer (SCLC) with surgical resection has not been fully identified...
  78. ncbi Local delivery of ferrociphenol lipid nanocapsules followed by external radiotherapy as a synergistic treatment against intracranial 9L glioma xenograft
    Emilie Allard
    Inserm U646, Pôle pharmaceutique, CHU d Angers, Universite d Angers, 49100, Angers, France
    Pharm Res 27:56-64. 2010
    ..We tested the hypothesis that the combination of external radiotherapy with Fc-diOH could potentiate the action of this drug...
  79. ncbi Temozolomide in advanced malignant melanoma with small brain metastases: can we withhold cranial irradiation?
    Willem Boogerd
    Department of Neuro Oncology, Netherlands Cancer Institute, Amsterdam, Netherlands
    Cancer 109:306-12. 2007
    ..In this study, the authors evaluated the efficacy of treatment with temozolomide in patients with metastatic melanoma, including small brain metastases, who did not require immediate RT and investigated the feasibility of deferring RT...
  80. ncbi Thirty years of prophylactic cranial irradiation in patients with small cell lung cancer: a meta-analysis of randomized clinical trials
    Gustavo Arruda Viani
    Departamento de Radioterapia e Oncologia, Faculdade de Medicina de Marilia, Marilia, SP, Brazil
    J Bras Pneumol 38:372-81. 2012
    To determine the role of prophylactic cranial irradiation (PCI) in patients with small cell lung cancer (SCLC).
  81. ncbi Long-term cerebral metabolite changes on proton magnetic resonance spectroscopy in patients cured of acute lymphoblastic leukemia with previous intrathecal methotrexate and cranial irradiation prophylaxis
    Y L Chan
    Department of Diagnostic Radiology and Organ Imaging, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China
    Int J Radiat Oncol Biol Phys 50:759-63. 2001
    ..the long-term brain metabolite changes on (1)H-MRS in acute lymphoblastic leukemia (ALL) patients who had intrathecal methotrexate (ITMTX) and cranial irradiation (CRT) for central nervous system (CNS) prophylaxis against CNS relapse.
  82. ncbi Paternal cranial irradiation induces distant bystander DNA damage in the germline and leads to epigenetic alterations in the offspring
    Jan Tamminga
    Department of Biological Sciences, University of Lethbridge, Alberta, Canada
    Cell Cycle 7:1238-45. 2008
    ..To investigate whether or not the paternal cranial irradiation can exert deleterious changes in the protected germline, we studied the accumulation of DNA damage in the ..
  83. ncbi Whole-brain radiotherapy combined with surgery or stereotactic radiotherapy in patients with brain oligometastases: long-term analysis
    Giuseppe Roberto D'Agostino
    Dept of Radiation Oncology, Catholic University of the Sacred Heart, Rome, Italy
    Strahlenther Onkol 187:421-5. 2011
    ..To verify whether the treatment of brain oligometastases with whole-brain radiotherapy (WBRT) plus stereotactic radiotherapy (SRT) or surgical resection results in different outcomes...
  84. ncbi Prophylactic cranial irradiation revisited: cost-effectiveness and quality of life in small-cell lung cancer
    T H Patricia Tai
    Department of Radiation Oncology, Allan Blair Cancer Center, Regina, Saskatchewan, Canada
    Int J Radiat Oncol Biol Phys 52:68-74. 2002
    To investigate the therapeutic usefulness and cost-effectiveness of prophylactic cranial irradiation (PCI) in patients with limited-stage small-cell lung cancer (SCLC) who had achieved a complete remission.
  85. ncbi A case series of pediatric primary central nervous system lymphoma: favorable outcome without cranial irradiation
    Oussama Abla
    Division of Hematology Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada
    Pediatr Blood Cancer 47:880-5. 2006
    ..To describe the outcome of childhood primary central nervous system lymphoma (PCNSL) treated with chemotherapy alone or with chemotherapy plus cranial radiotherapy (CRT)...
  86. ncbi Impact of prophylactic cranial irradiation timing on brain relapse rates in patients with stage IIIB non-small-cell lung carcinoma treated with two different chemoradiotherapy regimens
    Erkan Topkan
    Baskent University Adana Medical Faculty, Department of Radiation Oncology, Kisla Saglik Yerleskesi, Adana, Turkey
    Int J Radiat Oncol Biol Phys 83:1264-71. 2012
    To retrospectively assess the influence of prophylactic cranial irradiation (PCI) timing on brain relapse rates in patients treated with two different chemoradiotherapy (CRT) regimens for Stage IIIB non-small-cell lung cancer (NSCLC).
  87. ncbi Growth hormone treatment impact on growth rate and final height of patients who received HSCT with TBI or/and cranial irradiation in childhood: a report from the French Leukaemia Long-Term Follow-Up Study (LEA)
    F Isfan
    CHU Clermont Ferrand, Centre Régional de Cancérologie et Thérapie Cellulaire Pédiatrique, hôpital Estaing, Clermont Ferrand, France
    Bone Marrow Transplant 47:684-93. 2012
    ..influence the linear growth in up to 85% of patients undergoing haematopoietic SCT (HSCT) with TBI and/or cranial irradiation (CI) for acute leukaemia (AL)...
  88. ncbi Prophylactic cranial irradiation for preventing brain metastases in patients undergoing radical treatment for non-small-cell lung cancer: a Cochrane Review
    Jason Francis Lester
    Department of Oncology, Velindre Hospital, Whitchurch, Cardiff, Wales, United Kingdom
    Int J Radiat Oncol Biol Phys 63:690-4. 2005
    To investigate whether prophylactic cranial irradiation (PCI) has a role in the management of patients with non-small-cell lung cancer (NSCLC) treated with curative intent.
  89. ncbi Prophylactic cranial irradiation in lung cancer
    Pierre Blanchard
    Radiation Oncology Department, Institut Gustave Roussy, Villejuif, France
    Curr Opin Oncol 22:94-101. 2010
    ..Prophylactic cranial irradiation (PCI) has been proposed in both small-cell lung cancers (SCLCs) and non-SCLCs to reduce the incidence of ..
  90. ncbi Prophylactic cranial irradiation in small cell lung cancer
    Cécile Le Péchoux
    Department of Radiotherapy, Institut Gustave Roussy, Villejuif 94805, France
    Hematol Oncol Clin North Am 18:355-72. 2004
  91. pmc Clinical neurological outcome and quality of life among patients with limited small-cell cancer treated with two different doses of prophylactic cranial irradiation in the intergroup phase III trial (PCI99-01, EORTC 22003-08004, RTOG 0212 and IFCT 99-01)
    C Le Pechoux
    Radiation Oncology Department, Institut Gustave Roussy, Villejuif, France
    Ann Oncol 22:1154-63. 2011
    We recently published the results of the PCI99 randomised trial comparing the effect of a prophylactic cranial irradiation (PCI) at 25 or 36 Gy on the incidence of brain metastases (BM) in 720 patients with limited small-cell lung cancer ..
  92. ncbi Decision analysis for prophylactic cranial irradiation for patients with small-cell lung cancer
    J Jack Lee
    Department of Biostatistics and Applied Mathematics, The University of Texas M D Anderson Cancer Center, Houston, TX 77030 4009, USA
    J Clin Oncol 24:3597-603. 2006
    Prophylactic cranial irradiation (PCI) has been shown to provide survival benefit in patients with limited disease small-cell lung cancer (LD-SCLC) who have achieved complete response...
  93. ncbi Therapeutic doses of cranial irradiation induce hippocampus-dependent cognitive deficits in young mice
    Amulya A Nageswara Rao
    Division of Pediatric Hematology Oncology, Department of Pediatrics and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA
    J Neurooncol 105:191-8. 2011
    Fractionated cranial irradiation is an essential part of treatment in the management of cohorts of pediatric brain tumor and leukemia patients...
  94. ncbi Secondary intracranial meningiomas after high-dose cranial irradiation: report of five cases and review of the literature
    P Strojan
    Department of Radiotherapy, Institute of Oncology, Ljubljana
    Int J Radiat Oncol Biol Phys 48:65-73. 2000
    To review cases of secondary intracranial meningiomas following high-dose cranial irradiation (>/= 10 Gy) identified in Slovenia between 1968 and 1998, to determine their histological profile and to review the literature on this topic.
  95. ncbi Primitive neuroectodermal tumors in the central nervous system following cranial irradiation: a report of four cases
    Walter J Hader
    Division of Neurosurgery, Department of Clinical Neurosciences, University of Calgary, Calgary, Canada
    Cancer 97:1072-6. 2003
    ..The authors present four additional cases of PNETs that developed after previous cranial irradiation.
  96. ncbi Radiation induced meningioma with a short latent period following high dose cranial irradiation - case report and literature review
    Ajay Choudhary
    Department of Neurosurgery, Institute of Medical Sciences, Banaras Hindu University, Varanasi, 221 005, Uttar Pradesh, India
    J Neurooncol 77:73-7. 2006
    ..7+/-10.2 years. There are only 9 reported cases of RIM following high dose cranial irradiation with unusually short latency periods of less than 5 years...
  97. ncbi [Surgical treatment for primary non-small cell lung cancer with synchronous brain metastases]
    Y Yoshinaga
    Department of Thoracic Surgery, St Mary s Hospital, Kerume, Japan
    Kyobu Geka 59:41-5. 2006
    ..Multivariate analysis found that only adeocarcinoma histology also affected the survival. It is concluded that surgical treatment may acceptable in selected group of non-small cell lung cancer patients with synchronous brain metastases...
  98. pmc Long-term follow-up of the United Kingdom medical research council protocols for childhood acute lymphoblastic leukaemia, 1980-2001
    C Mitchell
    Department of Paediatric Haematology Oncology, John Radcliffe Hospital, Oxford, UK
    Leukemia 24:406-18. 2010
    ..Over the era encompassed by these four trials, there has been a major improvement in both event-free and overall survival for children in the United Kingdom with ALL...
  99. ncbi Management and prognosis in synchronous solitary resected brain metastasis from non-small-cell lung cancer
    Alexander V Louie
    Department of Radiation Oncology, London Regional Cancer Program, London, Ontario, Canada
    Clin Lung Cancer 10:174-9. 2009
    ..The objective of this research is to analyze prognostic factors that predict for outcome in this unique patient population...
  100. ncbi Lung cancer and its operable brain metastasis: survival rate and staging problems
    Jozsef Furak
    Departments of Medical Informatics, Pathology, and Surgery, University of Szeged, Szeged
    Ann Thorac Surg 79:241-7; discussion 241-7. 2005
    ..The correlation between survival rates and the disease-free interval between lung surgery and metastasectomy was studied...
  101. ncbi Pseudomigraine with prolonged aphasia in a child with cranial irradiation for medulloblastoma
    S N Krishna Murthy
    Department of Neurology, SUNY Buffalo, Children s Hospital of Buffalo, New York 14222, USA
    J Child Neurol 17:134-8. 2002
    ..This presentation mimics migraine headache. Evidence suggesting that this represents a long-term complication of treatment of children with central nervous system neoplasia is presented...

Research Grants62

  1. Innate immunity in Rett pathology and repair
    Jonathan Kipnis; Fiscal Year: 2013
    ..However, when cranial irradiation was blocked by lead shield, and microglial engraftment was prevented, disease was not arrested...
  2. Radiation and Oxidative Stress: Effects on Neurogenesis
    John R Fike; Fiscal Year: 2012
    ..b>Cranial irradiation can induce cognitive impairments that involve the hippocampus, a structure critical for learning and memory...
  3. Mechanisms of T cell leukemia induction and maintenance
    Iannis Aifantis; Fiscal Year: 2013
    ..For that reason, T-ALL patients usually receive cranial irradiation in addition to intensified intrathecal chemotherapy...
  4. IMAGING BIOMARKERS FOR RADIATION-INDUCED NECROSIS
    Joel Richard Garbow; Fiscal Year: 2013
    ..of experiments will result in a significantly clearer understanding of the brain tissue changes that follow cranial irradiation. The ability to monitor these changes non-invasively, and to prevent and mitigate these changes with ..
  5. Rescuing radiation-induced cognitive deficits through cranial transplantation of
    Charles Limoli; Fiscal Year: 2013
    ..Even low doses of cranial irradiation that elicit minimal morphologic injury can result in variable degrees of cognitive dysfunction that ..
  6. Phase III Study of Donepezil in the Irradiated Brain
    Stephen R Rapp; Fiscal Year: 2010
    ..there are very few available treatments for neurocognitive symptoms in patients who have received cranial irradiation;and no known preventive interventions exist...
  7. GSK3b mediates radiation-induced cytotoxicity in hippocampal neurons
    Fen Xia; Fiscal Year: 2013
    ..brain cancers, especially in children, is the long-term neurocognitive deficiencies resulting from cranial irradiation (IR)-induced hippocampal neuronal apoptosis...
  8. CLINICAL PHARMACOLOGY OF INTRATHECAL METHOTREXATE
    W Bleyer; Fiscal Year: 1980
    ..on cerebrospinal-fluid methotrexate concentration: intravenous infusions of high-dose methotrexate, cranial irradiation, systemic and intrathecal probenicid administration, body position and hyperbaric (D10W-Trendelenberg) ..
  9. Characterizing the Obesity of Long-term Cancer Survivors
    Susan Nunez; Fiscal Year: 2005
    ..study to determine the role of neuropeptides in the development of obesity in cancer survivors treated with cranial irradiation with or without surgery...
  10. NEUROTOXICITY OF CNS PROPHYLACTIC THERAPIES IN ALL
    PHYLLIS MULLENIX; Fiscal Year: 1993
    ..span of the rat, young male and female animals are exposed to various CNS prophylactic treatments involving cranial irradiation, methotrexate, and prednisolone...
  11. Inflammatory Modulation of Neural Stem Cell Function
    Theo Palmer; Fiscal Year: 2009
    ..drug, restores neurogenesis following endotoxin-induced inflammation and augments neurogenesis following cranial irradiation. In addition, animals with deficits in the chemokine MCP-1 are resistant to the long-term effects of ..
  12. CONSEQUENCES OF CNS PROPHYLAXIS IN CHILDREN WITH ALL
    Deborah Waber; Fiscal Year: 1993
    ..aim of the research will be to determine whether application of a hyperfractionation schedule to deliver cranial irradiation (XRT) can reduce toxicity without sacrificing efficacy...
  13. Quantifying Radiation-Therapy Brain Injury With 1H-MRS
    Oded Gonen; Fiscal Year: 2003
    ..H2: That WBNAA is more sensitive than MMSE to detect neuronal injury consequences of WBRT. H3: That this neuronal injury may be transient, in part, and could resolve within several months after WBRT. ..
  14. Lapatinib in childhood CNS malignancies
    Maryam Fouladi; Fiscal Year: 2006
    ..These data will be used in the rational design of future phase I combination or frontline studies to improve the outcome in children with these poor prognosis tumors. [unreadable] [unreadable]..
  15. PREMATURE MENOPAUSE IN SURVIVORS OF CHILDHOOD CANCER
    Charles Sklar; Fiscal Year: 2002
    ..The large size of the study population, the heterogeneity of diagnoses and exposures, combined with the extensive treatment data, will allow assessment of interaction between the major risk factors of interest. ..
  16. NABTC (UCSF PROJECT LEADER) U OF WISCONSIN
    Minesh Mehta; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  17. GENETIC MODIFIERS AND LONGEVITY OF MNSOD MUTANT MICE
    Ting Ting Huang; Fiscal Year: 2003
    ..Aim III - Functional studies of the genetic modifier by phenotype analyses of Sod2-/- mice. Aim IV - Identification of the major modifier gene leading to prolonged lifespan in MnSOD mutant mice. ..
  18. Genetics Modifiers and Longevity of MnSOD Mutant Mice
    Ting Ting Huang; Fiscal Year: 2008
    ..Aim 2: Mechanistic analysis of Nnt as the genetic modifier of Sod2-/-. Aim 3: Validation of Nnt as a longevity assurance gene (LAG). ..
  19. NABTT-Consortium Therapeutic Studies of CNS Malignancies
    Stuart Grossman; Fiscal Year: 2008
    ..abstract_text> ..
  20. Participating Member Institution in NABTC
    Lisa DeAngelis; Fiscal Year: 2008
    ..abstract_text> ..
  21. Mammography and High-Risk Survivors of Pediatric Cancer
    Kevin Oeffinger; Fiscal Year: 2005
    ....
  22. PROJECT ALLIFE-EXERCISE AND LEUKEMIA SURVIVORS
    Kevin Oeffinger; Fiscal Year: 2006
    ..This study will represent the first clinical trial aimed at increasing physical activity in leukemia survivors and will advance our understanding of this vulnerable population. ..
  23. Regulation of VEGF/HIF-1 by AKT: Implications for Radiotherapy
    Amit Maity; Fiscal Year: 2010
    ..Increased oxygenation should make tumors more sensitive to radiation;therefore, our studies may be important in helping to optimize the combination of EGFR inhibitors with radiation. ..
  24. Improving Cancer Outcome--Adaptive Helical Tomotherapy
    Minesh Mehta; Fiscal Year: 2005
    ..Our Program Project will allow Tomotherapy to reach a level of scientific and technological maturity where, in the future, technological intercomparisons through Phase III trials may be undertaken. ..
  25. Molecular Analysis-Directed Individualised Therapy in Ad
    George Simon; Fiscal Year: 2005
    ..Patients will be followed till death and survival curves will be generated. ..
  26. Obesity in Hispanic Children with Leukemia
    Jacques Baillargeon; Fiscal Year: 2005
    ..A number of factors, including exposure to corticosteroids, exposure to cranial irradiation, and diminished exercise capacity reportedly contribute to increased rates of obesity among ALL survivors...
  27. Mechanisms of Radiation-Induced Cognitive Dysfunction
    William Brown; Fiscal Year: 2008
    ..Such therapeutic intervention studies could potentially be performed in as little as 10 weeks. ..
  28. Symptom Measurement and Interrelationships During Chemotherapy for Ovarian Cancer
    Heather Jim; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  29. Musculoskeletal Outcomes in Pediatric BMT
    Kathy Ruble; Fiscal Year: 2008
    ..4. Compare the HRQOL of survivors who are at least two years post childhood BMT to established norms from healthy children. [unreadable] [unreadable] [unreadable]..
  30. PATHOGENESIS OF RADIATION-INDUCED KIDNEY INJURY
    Michael Robbins; Fiscal Year: 2004
    ..These studies offer the promise of developing rational therapeutic strategies directed at reducing the severity of this dose-limiting morbidity in human beings. ..
  31. PUFA-MEDIATED MODULATION OF RAT CATALASE EXPRESSION
    Michael Robbins; Fiscal Year: 2003
    ....
  32. Cognitive Studies of Temporal Lobe Function in Man
    Guila Glosser; Fiscal Year: 2003
    ..b) To assess the usefulness of presurgical fMRI activation measures during an allocentric spatial memory task for predicting memory performance following ATL. ..
  33. CHILDRENS NATIONAL MEDICAL CENTER
    Roger Packer; Fiscal Year: 2003
    ....
  34. Neural Predictors and RAS Modulation of Radiation-induced Cognitive Impairment
    Michael E Robbins; Fiscal Year: 2010
    ..These studies should provide information that is likely to lead to treatments that ameliorate radiation-induced brain injury, including cognitive impairment;thereby, addressing one of NCI's new areas of public health emphasis. ..
  35. PHASE I TRIALS OF ANTICANCER AGENTS
    Martin Edelman; Fiscal Year: 2002
    ....
  36. The Renin-Angiotensin System, Inflammation and Radiation-induced Brain Injury
    Michael E Robbins; Fiscal Year: 2010
    ....
  37. Cytokines in radiation lung injury
    ARTHUR BLACKSTOCK; Fiscal Year: 2003
    ..Even further, understanding the temporal expression of MIP-1alpha during thoracic radiation may allow the future utilization of anticytokine reagents, e.g. antibodies, receptor and synthesis blockers during treatment. ..
  38. NEUROGENESIS AND COGNITION IN IRRADIATED YOUNG MICE
    JOHN FIKE; Fiscal Year: 2002
    ..abstract_text> ..
  39. COGNITIVE REMEDIATION FOR CHILDHOOD CANCER SURVIVORS
    Robert Butler; Fiscal Year: 2002
    ..Secondary and exploratory analyses will examine the influences of maternal factors on CRP adherence and effectiveness. ..
  40. CANCER AND LEUKEMIA GROUP B
    Martin Edelman; Fiscal Year: 2002
    ..The grant will also allow for continuation of meritorious pilot protocols and will allow GCC to monitor and collect data which will produce mutual benefit to the GCC and CALGB. ..
  41. Therapeutic Studies of Primary CNS Malignancies-NABTT
    Gene Barnett; Fiscal Year: 2008
    ..abstract_text> ..
  42. Obstructive Sleep Apnea (OSA) in obese teens & preteens: Neurobahavioral effects
    Dean Beebe; Fiscal Year: 2008
    ..abstract_text> ..
  43. Anticancer Agent Pharmacodynamics in Acute Leukemia
    Mary Relling; Fiscal Year: 2006
    ..Our long- term goal is to identify host- and treatment-related risk factors for t-AML so that we can design less leukemogenic anticancer treatment regimens, with improved efficacy for the primary ALL. ..
  44. A MULTI-USE GLIOMA BIOREPOSITORY
    Tom Mikkelsen; Fiscal Year: 2006
    ..We seek support to expand this multi-use glioma biorepository into an ongoing resource of the best characterized glioma material with clinical correlative and genomic data available. ..
  45. MOLECULAR GLIOMA THERAPIES AND DIAGNOSTICS
    Tom Mikkelsen; Fiscal Year: 2004
    ..abstract_text> ..
  46. Indomethacin and p38 Regulating AP-1 In Heat Shock
    Jacob Locke; Fiscal Year: 2004
    ..abstract_text> ..
  47. Genetics of Cognitive Decline Post Cancer Chemotherapy
    Tim Ahles; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  48. Metabolic Syndrome in Adult Survivors of Childhood ALL
    James Gurney; Fiscal Year: 2005
    ..abstract_text> ..
  49. Extracranial Stereotactic Radioablation in Lung Cancer
    Ronald McGarry; Fiscal Year: 2004
    ....
  50. RADIATION RESPONSE OF THE NORMAL SUBEPENDYMA
    JOHN FIKE; Fiscal Year: 2001
    ..abstract_text> ..
  51. Web-Based Instruction for Medical Dosimetrists
    Paul Keall; Fiscal Year: 2006
    ..abstract_text> ..
  52. Genetic Mutations in Gliomatosis Cerebri
    Marcus Ware; Fiscal Year: 2004
    ..We shall use this data to determine if there are specific patterns of chromosome aberrations that are characteristic of GC. Our final goal is to compare copy-number aberrations seen in GC to those seen in other non-GC astrocytic tumors. ..
  53. THERAPEUTICS STUDIES OF PRIMARY CNS MALIGNANCIES
    Patrick Wen; Fiscal Year: 2008
    ..abstract_text> ..
  54. NEW APPLICATIONS IN BRAIN TUMOR THERAPY
    Tom Mikkelsen; Fiscal Year: 2008
    ..These efforts speak to the ultimate goal of our group and NABTT Consortium: improving the outcome of brain tumor patients. ..
  55. Adolescent Gastric By-Pass and Diabetic Precursors
    Thomas Inge; Fiscal Year: 2006
    ....
  56. Pirfenidone in Children with PNs in NF1
    Roger Packer; Fiscal Year: 2006
    ..Abstract Not Provided ..
  57. Neurogenesis, Inflammation and Irradiation Injury
    MICHELLE MONJE DEISSEROTH; Fiscal Year: 2003
    ..abstract_text> ..
  58. Androgens and apoE4 induced cognitive impairments
    Jacob Raber; Fiscal Year: 2005
    ....
  59. Epigenetic Potentiation of Interferon using Decitabine
    Wolfram Samlowski; Fiscal Year: 2008
    ..Additional experiments will evaluate interferon signaling and DNA damage response pathways in normal and neoplastic cells. [unreadable] [unreadable] [unreadable]..
  60. IASLC Biology and Prevention of Lung Cancer Workshop
    James Rigas; Fiscal Year: 2005
    ..Funds in the amount of $12,000 are requested to cover partial travel expenses for out-of-town speakers. ..