conformal radiotherapy

Summary

Summary: Radiotherapy where there is improved dose homogeneity within the tumor and reduced dosage to uninvolved structures. The precise shaping of dose distribution is achieved via the use of computer-controlled multileaf collimators.

Top Publications

  1. ncbi Radiation-induced second cancers: the impact of 3D-CRT and IMRT
    Eric J Hall
    Center for Radiological Research, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
    Int J Radiat Oncol Biol Phys 56:83-8. 2003
  2. ncbi Incidence of late rectal and urinary toxicities after three-dimensional conformal radiotherapy and intensity-modulated radiotherapy for localized prostate cancer
    Michael J Zelefsky
    Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Int J Radiat Oncol Biol Phys 70:1124-9. 2008
  3. ncbi Escalated-dose versus standard-dose conformal radiotherapy in prostate cancer: first results from the MRC RT01 randomised controlled trial
    David P Dearnaley
    Institute of Cancer Research and Royal Marsden Hospitals, Sutton and London, UK
    Lancet Oncol 8:475-87. 2007
  4. ncbi Comparison of conventional-dose vs high-dose conformal radiation therapy in clinically localized adenocarcinoma of the prostate: a randomized controlled trial
    Anthony L Zietman
    Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    JAMA 294:1233-9. 2005
  5. ncbi Volumetric modulated arc therapy for delivery of prostate radiotherapy: comparison with intensity-modulated radiotherapy and three-dimensional conformal radiotherapy
    David Palma
    Radiation Oncology Program, British Columbia Cancer Agency, Vancouver, BC, Canada
    Int J Radiat Oncol Biol Phys 72:996-1001. 2008
  6. ncbi Dose-volumetric parameters predicting radiation-induced hepatic toxicity in unresectable hepatocellular carcinoma patients treated with three-dimensional conformal radiotherapy
    Tae Hyun Kim
    Research Institute and Hospital, National Cancer Center, Goyang, Republic of Korea
    Int J Radiat Oncol Biol Phys 67:225-31. 2007
  7. ncbi Portal imaging to assess set-up errors, tumor motion and tumor shrinkage during conformal radiotherapy of non-small cell lung cancer
    Sara C Erridge
    Edinburgh Cancer Centre, Western General Hospital, Crewe Road South, Edinburgh, UK
    Radiother Oncol 66:75-85. 2003
  8. ncbi Combined therapy of transcatheter arterial chemoembolisation and three-dimensional conformal radiotherapy for hepatocellular carcinoma
    Z H Zhou
    Department of Integrative Chinese and Western Medicine, Fudan University Cancer Hospital, Shanghai 200032, China
    Br J Radiol 80:194-201. 2007
  9. ncbi Analysis of related factors associated with radiation pneumonitis in patients with locally advanced non-small-cell lung cancer treated with three-dimensional conformal radiotherapy
    Jun Dang
    Department of Radiation Oncology, The First Affiliated Hospital of China Medical University, 110001, Shenyang, China
    J Cancer Res Clin Oncol 136:1169-78. 2010
  10. ncbi Radiation-induced liver disease after three-dimensional conformal radiotherapy for patients with hepatocellular carcinoma: dosimetric analysis and implication
    Jason Chia Hsien Cheng
    Department of Radiation Oncology, Koo Foundation Sun Yat Sen Cancer Center, No 125 Lih Der Road, Pei tou District, Taipei 112, Taiwan
    Int J Radiat Oncol Biol Phys 54:156-62. 2002

Research Grants

Detail Information

Publications324 found, 100 shown here

  1. ncbi Radiation-induced second cancers: the impact of 3D-CRT and IMRT
    Eric J Hall
    Center for Radiological Research, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
    Int J Radiat Oncol Biol Phys 56:83-8. 2003
    ..75% for patients surviving 10 years. The numbers may be larger for longer survival (or for younger patients), but the ratio should remain the same...
  2. ncbi Incidence of late rectal and urinary toxicities after three-dimensional conformal radiotherapy and intensity-modulated radiotherapy for localized prostate cancer
    Michael J Zelefsky
    Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Int J Radiat Oncol Biol Phys 70:1124-9. 2008
    To report the incidence and predictors of treatment-related toxicity at 10 years after three-dimensional conformal radiotherapy (3D-CRT) and intensity-modulated radiotherapy (IMRT) for localized prostate cancer.
  3. ncbi Escalated-dose versus standard-dose conformal radiotherapy in prostate cancer: first results from the MRC RT01 randomised controlled trial
    David P Dearnaley
    Institute of Cancer Research and Royal Marsden Hospitals, Sutton and London, UK
    Lancet Oncol 8:475-87. 2007
    In men with localised prostate cancer, conformal radiotherapy (CFRT) could deliver higher doses of radiation than does standard-dose conventional radical external-beam radiotherapy, and could improve long-term efficacy, potentially at the ..
  4. ncbi Comparison of conventional-dose vs high-dose conformal radiation therapy in clinically localized adenocarcinoma of the prostate: a randomized controlled trial
    Anthony L Zietman
    Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    JAMA 294:1233-9. 2005
    ..Clinically localized prostate cancer is very prevalent among US men, but recurrence after treatment with conventional radiation therapy is common...
  5. ncbi Volumetric modulated arc therapy for delivery of prostate radiotherapy: comparison with intensity-modulated radiotherapy and three-dimensional conformal radiotherapy
    David Palma
    Radiation Oncology Program, British Columbia Cancer Agency, Vancouver, BC, Canada
    Int J Radiat Oncol Biol Phys 72:996-1001. 2008
    ..The goal of this study was to compare VMAT prostate RT plans with three-dimensional conformal RT (3D-CRT) and IMRT plans...
  6. ncbi Dose-volumetric parameters predicting radiation-induced hepatic toxicity in unresectable hepatocellular carcinoma patients treated with three-dimensional conformal radiotherapy
    Tae Hyun Kim
    Research Institute and Hospital, National Cancer Center, Goyang, Republic of Korea
    Int J Radiat Oncol Biol Phys 67:225-31. 2007
    To identify the dose-volumetric parameters associated with the risk of radiation-induced hepatic toxicity (RIHT) in hepatocellular carcinoma patients treated with three-dimensional conformal radiotherapy.
  7. ncbi Portal imaging to assess set-up errors, tumor motion and tumor shrinkage during conformal radiotherapy of non-small cell lung cancer
    Sara C Erridge
    Edinburgh Cancer Centre, Western General Hospital, Crewe Road South, Edinburgh, UK
    Radiother Oncol 66:75-85. 2003
    To investigate patient set-up, tumor movement and shrinkage during 3D conformal radiotherapy for non-small cell lung cancer.
  8. ncbi Combined therapy of transcatheter arterial chemoembolisation and three-dimensional conformal radiotherapy for hepatocellular carcinoma
    Z H Zhou
    Department of Integrative Chinese and Western Medicine, Fudan University Cancer Hospital, Shanghai 200032, China
    Br J Radiol 80:194-201. 2007
    To evaluate the toxicity and efficacy of combined therapy of three-dimensional conformal radiotherapy (3DCRT) and transcatheter arterial chemoembolisation (TACE) for hepatocellular carcinoma (HCC)...
  9. ncbi Analysis of related factors associated with radiation pneumonitis in patients with locally advanced non-small-cell lung cancer treated with three-dimensional conformal radiotherapy
    Jun Dang
    Department of Radiation Oncology, The First Affiliated Hospital of China Medical University, 110001, Shenyang, China
    J Cancer Res Clin Oncol 136:1169-78. 2010
    ..RP) in patients with locally advanced non-small-cell lung cancer (NSCLC) treated with three-dimensional conformal radiotherapy (3D-CRT), and the differences between patients treated with 3D-CRT alone or that combined with ..
  10. ncbi Radiation-induced liver disease after three-dimensional conformal radiotherapy for patients with hepatocellular carcinoma: dosimetric analysis and implication
    Jason Chia Hsien Cheng
    Department of Radiation Oncology, Koo Foundation Sun Yat Sen Cancer Center, No 125 Lih Der Road, Pei tou District, Taipei 112, Taiwan
    Int J Radiat Oncol Biol Phys 54:156-62. 2002
    ..dose-volume factors and to describe the probability of RILD by a normal tissue complication probability (NTCP) model for patients with hepatocellular carcinoma (HCC) treated with three-dimensional conformal radiotherapy (3D-CRT).
  11. pmc Phase III pilot study of dose escalation using conformal radiotherapy in prostate cancer: PSA control and side effects
    D P Dearnaley
    Academic Department of Radiotherapy and Oncology, Institute of Cancer Research, Sutton, Surrey SM2 5PT, UK
    Br J Cancer 92:488-98. 2005
    ..In conclusion, dose escalation from 64 to 74 Gy using conformal radiotherapy may improve long-term PSA control, but a treatment margin of 1...
  12. ncbi Towards multidimensional radiotherapy (MD-CRT): biological imaging and biological conformality
    C C Ling
    Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Int J Radiat Oncol Biol Phys 47:551-60. 2000
    ..to survey and summarize the advances in imaging that have potential applications in radiation oncology, and to explore the concept of integrating physical and biological conformality in multidimensional conformal radiotherapy (MD-CRT).
  13. ncbi Hepatitis B virus reactivation after three-dimensional conformal radiotherapy in patients with hepatitis B virus-related hepatocellular carcinoma
    Ji Hoon Kim
    Center for Liver Cancer, National Cancer Center, Goyang, Gyeonggi 411 764, South Korea
    Int J Radiat Oncol Biol Phys 69:813-9. 2007
    To investigate whether three-dimensional conformal radiotherapy (3D-CRT) influences hepatitis B virus (HBV) reactivation and chronic hepatitis B (CHB) exacerbation in patients with HBV-related hepatocellular carcinoma (HCC).
  14. ncbi Acute esophageal toxicity in non-small cell lung cancer patients after high dose conformal radiotherapy
    Jose Belderbos
    Department of Radiation Oncology, The Netherlands Cancer Institute Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands
    Radiother Oncol 75:157-64. 2005
    ..To correlate acute esophageal toxicity with dosimetric and clinical parameters for non-small cell lung cancer (NSCLC) patients treated with radiotherapy (RT) alone or with chemo-radiotherapy (CRT)...
  15. ncbi Intensity-modulated radiation therapy (IMRT) reduces small bowel, rectum, and bladder doses in patients with cervical cancer receiving pelvic and para-aortic irradiation
    L Portelance
    Department of Radiology, Radiation Oncology Center, Mallinckrodt Institute of Radiology, Washington University Medical Center, St. Louis, MO 63110, USA
    Int J Radiat Oncol Biol Phys 51:261-6. 2001
    ..48 +/- 31.80%) techniques (p < 0.05). CONCLUSION: In this dosimetric study, we demonstrated that with similar target coverage, normal tissue sparing is superior with IMRT in the treatment of cervical cancer...
  16. ncbi Nasopharyngeal carcinoma. Treatment planning with IMRT and 3D conformal radiotherapy
    Claus A Kristensen
    Department of Oncology, Rigshospitalet, Copenhagen University Hospital, Denmark
    Acta Oncol 46:214-20. 2007
    The study was undertaken in order to compare dose plans for intensity-modulated radiotherapy (IMRT) with 3D conformal radiotherapy (3D-CRT) dose plans in patients with nasopharyngeal carcinoma (NPC)...
  17. ncbi Intensity-modulated radiotherapy in patients with locally advanced rectal cancer reduces volume of bowel treated to high dose levels
    M Teresa Guerrero Urbano
    Department of Clinical Oncology, Royal Marsden NHS Trust, Sutton, Surrey, United Kingdom
    Int J Radiat Oncol Biol Phys 65:907-16. 2006
    ..To investigate the potential for intensity-modulated radiotherapy (IMRT) to spare the bowel in rectal tumors...
  18. ncbi Intensity-modulated whole pelvic radiation therapy in patients with gynecologic malignancies
    J C Roeske
    Department of Radiation and Cellular Oncology, University of Chicago, Chicago, IL 60637, USA
    Int J Radiat Oncol Biol Phys 48:1613-21. 2000
    ..To evaluate the ability of intensity-modulated radiation therapy (IMRT) to reduce the volume of small bowel irradiated in women with gynecologic malignancies receiving whole pelvic radiotherapy (WPRT)...
  19. pmc Adjuvant androgen deprivation impacts late rectal toxicity after conformal radiotherapy of prostate carcinoma
    G Sanguineti
    Department of Radiation Oncology, National Institute for Cancer Research, Genoa, Italy
    Br J Cancer 86:1843-7. 2002
    ..impacts late rectal toxicity in patients with localised prostate carcinoma treated with three-dimensional conformal radiotherapy. One hundred and eighty-two consecutive patients treated with 3DCRT between 1995 and 1999 at our ..
  20. ncbi Use of magnetic resonance imaging to assess blood-brain/blood-glioma barrier opening during conformal radiotherapy
    Yue Cao
    Department of Radiation Oncology, University of Michigan, 1500 E Medical Center Dr, Rm B2C438, Box 0010, Ann Arbor, MI 48109 0010, USA
    J Clin Oncol 23:4127-36. 2005
    ..The objective of this study was to assess BBB/BTB status using magnetic resonance imaging (MRI) during a course of radiotherapy of high-grade gliomas...
  21. pmc Intensity-modulated radiation therapy (IMRT) vs. 3D conformal radiotherapy (3DCRT) in locally advanced rectal cancer (LARC): dosimetric comparison and clinical implications
    Leire Arbea
    Department of Oncology, Clinica Universidad de Navarra, Pamplona, Spain
    Radiat Oncol 5:17. 2010
    ....
  22. ncbi Treatment of portal vein tumor thrombosis of hepatoma patients with either stereotactic radiotherapy or three-dimensional conformal radiotherapy
    Chun Shu Lin
    Department of Radiation Oncology, Tri Service General Hospital, 325 Section 2 Cheng Kong Rd, Nei Hu 11490, Taipei, Taiwan, ROC
    Jpn J Clin Oncol 36:212-7. 2006
    ..The purpose of this study was to analyze the recanalization rate of thrombosed portal vein and treatment toxicities after stereotactic radiotherapy (SRT) or three-dimensional conformal radiotherapy (3DCRT).
  23. pmc Late gastrointestinal toxicity after dose-escalated conformal radiotherapy for early prostate cancer: results from the UK Medical Research Council RT01 trial (ISRCTN47772397)
    Isabel Syndikus
    Clatterbridge Centre for Oncology, Bebington, United Kingdom
    Int J Radiat Oncol Biol Phys 77:773-83. 2010
    In men with localized prostate cancer, dose-escalated conformal radiotherapy (CFRT) improves efficacy outcomes at the cost of increased toxicity...
  24. ncbi Optimizing breast cancer treatment efficacy with intensity-modulated radiotherapy
    Frank A Vicini
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Int J Radiat Oncol Biol Phys 54:1336-44. 2002
    ..To present our clinical experience using intensity-modulated radiation therapy (IMRT) to improve dose uniformity and treatment efficacy in patients with early-stage breast cancer treated with breast-conserving therapy...
  25. ncbi Comparison of intensity-modulated radiotherapy and 3-dimensional conformal radiotherapy as adjuvant therapy for gastric cancer
    A Yuriko Minn
    Department of Radiation Oncology, Stanford University, Stanford, California 94305 5847, USA
    Cancer 116:3943-52. 2010
    ..was performed to compare the clinical outcomes and toxicity in patients treated with postoperative chemoradiotherapy for gastric cancer using intensity-modulated radiotherapy (IMRT) versus 3-dimensional conformal radiotherapy (3D CRT).
  26. ncbi Combined proton and photon conformal radiotherapy for intracranial atypical and malignant meningioma
    Christos Boskos
    Institut Curie, Centre de protonthérapie d Orsay, Campus Universitaire, Orsay, France
    Int J Radiat Oncol Biol Phys 75:399-406. 2009
    ..To evaluate retrospectively the efficacy of conformal fractionated radiotherapy combining proton and photon beams after primary surgery for treatment of atypical and malignant meningiomas...
  27. ncbi Dose selection for prostate cancer patients based on dose comparison and dose response studies
    G E Hanks
    Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Int J Radiat Oncol Biol Phys 46:823-32. 2000
    ..To better define the appropriate dose for individual prostate cancer patients treated with three-dimensional conformal radiation therapy (3D CRT)...
  28. ncbi Randomized phase II trial of induction chemotherapy followed by concurrent chemotherapy and dose-escalated thoracic conformal radiotherapy (74 Gy) in stage III non-small-cell lung cancer: CALGB 30105
    Mark A Socinski
    Lineberger Comprehensive Cancer Center, University of North Carolina Chapel Hill, NC 27599, USA
    J Clin Oncol 26:2457-63. 2008
    ..To evaluate 74 Gy thoracic radiation therapy (TRT) with induction and concurrent chemotherapy in stage IIIA/B non-small-cell lung cancer (NSCLC)...
  29. ncbi Quality of life and survival outcome for patients with nasopharyngeal carcinoma receiving three-dimensional conformal radiotherapy vs. intensity-modulated radiotherapy-a longitudinal study
    Fu Min Fang
    Department of Radiation Oncology, Chang Gung Memorial Hospital Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung Hsien, Taiwan
    Int J Radiat Oncol Biol Phys 72:356-64. 2008
    To investigate the changes of quality of life (QoL) and survival outcomes for patients with nasopharyngeal carcinoma (NPC) treated by three-dimensional conformal radiotherapy (3D-CRT) vs. intensity-modulated radiotherapy (IMRT).
  30. ncbi Proposed guidelines for image-based intracavitary brachytherapy for cervical carcinoma: report from Image-Guided Brachytherapy Working Group
    Subir Nag
    Ohio State University, Columbus, OH, USA
    Int J Radiat Oncol Biol Phys 60:1160-72. 2004
    ..To present issues to be considered in, and make proposals for, image-based brachytherapy for cervical cancer...
  31. ncbi Patterns of local-regional recurrence following parotid-sparing conformal and segmental intensity-modulated radiotherapy for head and neck cancer
    L A Dawson
    Department of Radiation Oncology, University of Michigan, Ann Arbor 48109 0010, USA
    Int J Radiat Oncol Biol Phys 46:1117-26. 2000
    ..To analyze the patterns of local-regional recurrence in patients with head and neck cancer treated with parotid-sparing conformal and segmental intensity-modulated radiotherapy (IMRT)...
  32. ncbi Acute and late complications after radiotherapy for prostate cancer: results of a multicenter randomized trial comparing 68 Gy to 78 Gy
    Stephanie T H Peeters
    Department of Radiotherapy, The Netherlands Cancer Institute Antoni van Leeuwenhoek Hospital, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands
    Int J Radiat Oncol Biol Phys 61:1019-34. 2005
    ..To compare acute and late gastrointestinal (GI) and genitourinary (GU) side effects in prostate cancer patients randomized to receive 68 Gy or 78 Gy...
  33. ncbi Radiation-induced liver disease in three-dimensional conformal radiation therapy for primary liver carcinoma: the risk factors and hepatic radiation tolerance
    Shi xiong Liang
    Department of Radiation Oncology, Fudan University Cancer Hospital, Shanghai, China
    Int J Radiat Oncol Biol Phys 65:426-34. 2006
    ..To identify risk factors relevant to radiation-induced liver disease (RILD) and to determine the hepatic tolerance to radiation...
  34. ncbi Association of DNA repair and steroid metabolism gene polymorphisms with clinical late toxicity in patients treated with conformal radiotherapy for prostate cancer
    Sambasivarao Damaraju
    Cross Cancer Institute, Department of Oncology, University of Alberta, Edmonton, Alberta, Canada
    Clin Cancer Res 12:2545-54. 2006
    ..recognition/repair/response and steroid metabolism proteins with respect to clinical radiation toxicity in a retrospective cohort of patients previously treated with three-dimensional conformal radiotherapy (3-DCRT) for prostate cancer.
  35. ncbi Prospective trial of combined transcatheter arterial chemoembolization and three-dimensional conformal radiotherapy for portal vein tumor thrombus in patients with unresectable hepatocellular carcinoma
    Kazunari Yamada
    Department of Radiology, Kobe University Graduate School of Medicine, Kobe, Japan
    Int J Radiat Oncol Biol Phys 57:113-9. 2003
    We conducted a prospective trial of combined transarterial chemoembolization (TACE) and three-dimensional conformal radiotherapy (3D-CRT) for portal vein tumor thrombus (PVTT) in unresectable hepatocellular carcinoma (HCC)...
  36. ncbi Xerostomia and its predictors following parotid-sparing irradiation of head-and-neck cancer
    A Eisbruch
    Department of Radiation Oncology, University of Michigan Hospital, Ann Arbor, MI 48109, USA
    Int J Radiat Oncol Biol Phys 50:695-704. 2001
    ..To assess long-term xerostomia in patients receiving parotid-sparing radiation therapy (RT) for head-and-neck cancer, and to find the patient and therapy-related factors that affect its severity...
  37. ncbi Radiation therapy for hepatocellular carcinoma: from palliation to cure
    Maria A Hawkins
    Department of Radiation Oncology, Princess Margaret Hospital, University of Toronto, Toronto, Ontario, Canada
    Cancer 106:1653-63. 2006
    ..3 months to 9.7 months. Although outcomes after high-dose conformal RT for liver-confined HCC were excellent, the potential survival benefit of RT should be tested in randomized controlled trials that require international collaboration...
  38. ncbi Evidence-based radiation oncology in head and neck squamous cell carcinoma
    Renzo Corvò
    Department of Radiation Oncology, National Cancer Research Institute and University, Genova, Italy
    Radiother Oncol 85:156-70. 2007
    ..These strategies are briefly reviewed in an effort to help interpret evidence-based data and to facilitate clinical-decision making in a clinical context...
  39. ncbi Phase III trial comparing whole-pelvic versus prostate-only radiotherapy and neoadjuvant versus adjuvant combined androgen suppression: Radiation Therapy Oncology Group 9413
    M Roach
    University of California San Francisco, 1600 Divisadero St, Suite H1031, San Francisco, CA 94143 1708, USA
    J Clin Oncol 21:1904-11. 2003
    ..This trial also tested the hypothesis that neoadjuvant and concurrent hormonal therapy (NCHT) improves PFS compared with adjuvant hormonal therapy (AHT) by 10%...
  40. ncbi The contribution of integrated PET/CT to the evolving definition of treatment volumes in radiation treatment planning in lung cancer
    Hani Ashamalla
    Department of Radiation Oncology, New York Methodist Hospital, Weill Medical College of Cornell University, Brooklyn, NY 11215, USA
    Int J Radiat Oncol Biol Phys 63:1016-23. 2005
    ....
  41. ncbi Volumetric and dosimetric evaluation of radiation treatment plans: radiation conformity index
    T Knöös
    Department of Radiation Physics, Lund University Hospital, Sweden
    Int J Radiat Oncol Biol Phys 42:1169-76. 1998
    ..We studied the degree of conformity reached in clinical routines for some common diagnoses treated at our department by calculating a radiation conformity index (RCI)...
  42. ncbi A prospective study on radiation pneumonitis following conformal radiation therapy in non-small-cell lung cancer: clinical and dosimetric factors analysis
    Line Claude
    Department of Radiation Oncology, Centre Léon Bérard 28, rue Laënnec 69373 Lyon Cedex 08, France
    Radiother Oncol 71:175-81. 2004
    Clinical and dosimetric prognostic factors for radiation pneumonitis (RP) have been reported after three-dimensional conformal radiotherapy (3D-CRT) in patients with non-small cell lung cancer (NSCLC).
  43. ncbi Treatment planning study to determine potential benefit of intensity-modulated radiotherapy versus conformal radiotherapy for unresectable hepatic malignancies
    Cynthia L Eccles
    Department of Radiation Oncology, Princess Margaret Hospital, University of Toronto, Toronto, ON, Canada
    Int J Radiat Oncol Biol Phys 72:582-8. 2008
    ..To compare intensity-modulated radiotherapy (IMRT) with conformal RT (CRT) for hypofractionated isotoxicity liver RT and explore dose escalation using IMRT for the same/improved nominal risk of liver toxicity in a treatment planning study...
  44. ncbi Combination of conformal radiotherapy and intratumoral injection of adoptive dendritic cell immunotherapy in refractory hepatoma
    Kwan Hwa Chi
    Department of Radiation Therapy and Oncology, Shin Kong Wu Ho Su Memorial Hospital, Taipei 111, Taiwan
    J Immunother 28:129-35. 2005
    ..5 x 10(7), 3 x 10(7), and 5 x 10(7) cells 2 days after a single fraction of conformal radiotherapy of 8 Gy. The second vaccination was performed 3 weeks later...
  45. ncbi Intensity-modulated radiation therapy for prostate cancer
    Michael J Zelefsky
    Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Semin Radiat Oncol 12:229-37. 2002
    ..Clinical trials will be necessary to define more clearly the true extent of improved tumor control and reduction in normal tissue complications with IMRT in the treatment of prostate cancer...
  46. pmc Radiation dose-volume effects in radiation-induced rectal injury
    Jeff M Michalski
    Department of Radiation Oncology, Washington University School of Medicine, St Louis, MO 63110, USA
    Int J Radiat Oncol Biol Phys 76:S123-9. 2010
    ..9 (73.7-80.1) Gy. Most of the models of late radiation toxicity come from three-dimensional conformal radiotherapy dose-escalation studies of early-stage prostate cancer...
  47. ncbi Clinical results of retreatment of vertebral bone metastases by stereotactic conformal radiotherapy and intensity-modulated radiotherapy
    Stefanie Milker-Zabel
    Department of Clinical Radiology, Radiation Therapy, University of Heidelberg, Heidelberg, Germany
    Int J Radiat Oncol Biol Phys 55:162-7. 2003
    ..We evaluated local control, pain relief, neurologic improvement, side effects, and survival rates after fractionated conformal radiotherapy (FCRT) and intensity-modulated RT (IMRT) of recurrent spinal metastases.
  48. ncbi Feasibility and efficacy of high-dose three-dimensional-conformal radiotherapy in cirrhotic patients with small-size hepatocellular carcinoma non-eligible for curative therapies--mature results of the French Phase II RTF-1 trial
    Francoise Mornex
    Department of Radiation Oncology, Centre Hospitalier Lyon Sud, Lyon, France
    Int J Radiat Oncol Biol Phys 66:1152-8. 2006
    ..Although conventional radiotherapy has been traditionally regarded as inefficient and toxic for cirrhotic patients, three-dimensional conformal radiotherapy (3DCRT) has provided promising preliminary data for the treatment of HCC.
  49. ncbi Esophageal cancer: determination of internal target volume for conformal radiotherapy
    F Lorchel
    Service de Radiotherapie, CHU Besancon, Bd Fleming, Besancon Cedex, France
    Radiother Oncol 80:327-32. 2006
    ..To evaluate esophageal tumor and OAR movement during the respiratory cycle in order to obtain optimal values for ITV and PRV. To correlate tumor motion with chest wall displacement - information of value in the free-breathing gating system...
  50. ncbi Combination of transarterial chemoembolization and three-dimensional conformal radiotherapy for hepatocellular carcinoma with inferior vena cava tumor thrombus
    Ja Eun Koo
    Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
    Int J Radiat Oncol Biol Phys 78:180-7. 2010
    To evaluate the effects of transarterial chemoembolization (TACE) and three-dimensional conformal radiotherapy (CRT) in patients with hepatocellular carcinoma (HCC) and inferior vena cava tumor thrombus (IVCTT).
  51. ncbi Loss of biological effect in prolonged fraction delivery
    Jack F Fowler
    Department of Human Oncology, Medical School, University of Wisconsin, Madison, WI 53792, USA
    Int J Radiat Oncol Biol Phys 59:242-9. 2004
    ..In this article, we model repair rates for a range of doses per fraction and draw conclusions...
  52. ncbi Magnetic resonance imaging system for three-dimensional conformal radiotherapy and its impact on gross tumor volume delineation of central nervous system tumors
    H Aoyama
    Department of Radiology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Int J Radiat Oncol Biol Phys 50:821-7. 2001
    ..We developed an MRI system for three-dimensional planning in radiotherapy. Its contribution on gross tumor volume (GTV) delineation of central nervous system (CNS) diseases was evaluated...
  53. ncbi Rectal sequelae after conformal radiotherapy of prostate cancer: dose-volume histograms as predictive factors
    S Wachter
    Department of Radiotherapy and Radiobiology, University Hospital of Vienna, Vienna, Austria
    Radiother Oncol 59:65-70. 2001
    ..of late rectal bleeding derived from cumulative dose-volume histograms (DVHs) of the rectum after conformal radiotherapy of prostate cancer...
  54. ncbi Predictors for chronic urinary toxicity after the treatment of prostate cancer with adaptive three-dimensional conformal radiotherapy: dose-volume analysis of a phase II dose-escalation study
    Asif Harsolia
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Int J Radiat Oncol Biol Phys 69:1100-9. 2007
    ..To identify factors predictive for chronic urinary toxicity secondary to high-dose adaptive three-dimensional conformal radiation...
  55. ncbi Variability in target volume delineation on CT scans of the breast
    C W Hurkmans
    Department of Radiotherapy, The Netherlands Cancer Institute/Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands
    Int J Radiat Oncol Biol Phys 50:1366-72. 2001
    ..in delineation of the target volume of breast tumors on computed tomography (CT) scans in order to perform conformal radiotherapy. MATERIALS AND METHODS: The clinical target volume (CTV) of the breast was delineated in CT slices by four ..
  56. ncbi Dose distribution analysis of axillary lymph nodes for three-dimensional conformal radiotherapy with a field-in-field technique for breast cancer
    Toshio Ohashi
    Department of Radiology, Keio University, School of Medicine, Tokyo, Japan
    Int J Radiat Oncol Biol Phys 73:80-7. 2009
    ..The purpose of this study was to determine whether the three-dimensional conformal radiotherapy (3D-CRT) with a field-in-field technique improves dosimetry for the breast and axillary nodes.
  57. ncbi Automatic selection of non-coplanar beam directions for three-dimensional conformal radiotherapy
    J Meyer
    University of Washington Medical Center, Department of Radiation Oncology, Box 356043, Seattle, WA 98195, USA
    Br J Radiol 78:316-27. 2005
    ..The approach provides a practical alternative to elaborate and time consuming beam angle optimization schemes and is suitable for routine clinical usage...
  58. ncbi Evidence-based review of three-dimensional conformal radiotherapy for localized prostate cancer: an ASTRO outcomes initiative
    David E Morris
    Department of Radiation Oncology, University of North Carolina, Chapel Hill, NC 27514, USA
    Int J Radiat Oncol Biol Phys 62:3-19. 2005
    ..a systematic review of the evidence to determine the efficacy and effectiveness of three-dimensional conformal radiotherapy (3D-CRT) for localized prostate cancer; provide a clear presentation of the key clinical outcome questions ..
  59. ncbi Intra-arterial 5-fluorouracil/interferon combination therapy for advanced hepatocellular carcinoma with or without three-dimensional conformal radiotherapy for portal vein tumor thrombosis
    Yoshio Katamura
    Department of Medicine and Molecular Science, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    J Gastroenterol 44:492-502. 2009
    The aim of this study was to elucidate the efficacy of intra-arterial 5-fluorouracil (5-FU) and interferon (IFN) alpha combined with three-dimensional conformal radiotherapy (3D-CRT) for portal vein tumor thrombosis (PVTT).
  60. ncbi Gastro-intestinal and genito-urinary morbidity after 3D conformal radiotherapy of prostate cancer: observations of a randomized trial
    Peter C Koper
    Erasmus MC Daniel den Hoed Cancer Center, Groene Hilledijk 301, 3075 EA Rotterdam, The Netherlands
    Radiother Oncol 73:1-9. 2004
    ..The difference in intestinal morbidity was analyzed as a function of the treatment arm and dose volume parameters. The correlation with acute toxicity and (pre-existing) bowel complaints was investigated...
  61. ncbi Bladder opacification does not significantly influence dose distribution in conformal radiotherapy of prostate cancer
    D C Weber
    Radiation Oncology Department of the University Hospital, Geneva, Switzerland
    Radiother Oncol 59:95-7. 2001
    ..the results of treatment planning with or without bladder contrast during simulation of three dimensional conformal radiotherapy (3D-CRT) for prostate cancer (18 MV X-rays, six field arrangement), and to assess the potential changes in ..
  62. ncbi Incorporating an improved dose-calculation algorithm in conformal radiotherapy of lung cancer: re-evaluation of dose in normal lung tissue
    Katrien De Jaeger
    Department of Radiotherapy, The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Radiother Oncol 69:1-10. 2003
    ..We also studied the consequences of these differences on the dose-effect relations for radiation-induced lung injury...
  63. ncbi Late rectal toxicity after conformal radiotherapy of prostate cancer (I): multivariate analysis and dose-response
    M W Skwarchuk
    Department of Medical Physics, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, USA
    Int J Radiat Oncol Biol Phys 47:103-13. 2000
    ....
  64. ncbi Is intensity-modulated radiotherapy better than conventional radiation treatment and three-dimensional conformal radiotherapy for mediastinal masses in patients with Hodgkin's disease, and is there a role for beam orientation optimization and dose constra
    Theodore Girinsky
    Department of Radiation Oncology, Institut Gustave Roussy, Villejuif, France
    Int J Radiat Oncol Biol Phys 64:218-26. 2006
    ..at protecting adjacent organs at risk (OARs), and to compare various intensity-modulated radiotherapy (IMRT) setups with conventional treatment with anterior and posterior fields and three-dimensional conformal radiotherapy (3D-CRT).
  65. ncbi Pretreatment nomogram predicting ten-year biochemical outcome of three-dimensional conformal radiotherapy and intensity-modulated radiotherapy for prostate cancer
    Michael J Zelefsky
    Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Urology 70:283-7. 2007
    ..our previously published nomogram predicting for biochemical outcome with 10-year data from a larger cohort of patients treated with three-dimensional conformal radiotherapy (RT) or intensity-modulated RT for localized prostate cancer.
  66. ncbi A radiotherapy planning study of RapidArc, intensity modulated radiotherapy, three-dimensional conformal radiotherapy, and parallel opposed beams in the treatment of pediatric retroperitoneal tumors
    Richard Shaffer
    Department of Radiation Oncology, BC Cancer Agency, Vancouver, British Columbia, Canada
    Pediatr Blood Cancer 56:16-23. 2011
    This planning study compared RapidArc, fixed-field IMRT (cIMRT), 3D conformal radiotherapy (3D-CRT), and a parallel-opposed pair (POP) for children with retroperitoneal tumors.
  67. ncbi Assessment of extended-field radiotherapy for stage IIIC endometrial cancer using three-dimensional conformal radiotherapy, intensity-modulated radiotherapy, and helical tomotherapy
    Jidong Lian
    Department of Radiation Oncology, Cross Cancer Institute and University of Alberta, Edmonton, AB, Canada
    Int J Radiat Oncol Biol Phys 70:935-43. 2008
    To perform a dosimetric comparison of three-dimensional conformal radiotherapy (3D-CRT), intensity-modulated radiotherapy (IMRT), and helical tomotherapy (HT) plans for pelvic and para-aortic RT in postoperative endometrial cancer ..
  68. ncbi Persistently better treatment planning results of intensity-modulated (IMRT) over conformal radiotherapy (3D-CRT) in prostate cancer patients with significant variation of clinical target volume and/or organs-at-risk
    Pascal Fenoglietto
    Département d Oncologie Radiothérapie, CRLC Val d Aurelle Paul Lamarque, Montpellier, France
    Radiother Oncol 88:77-87. 2008
    ..dose coverage of planning and clinical target volume (PTV, CTV), and organs-at-risk (OAR) between intensity-modulated (3D-IMRT) and conventional conformal radiotherapy (3D-CRT) before and after internal organ variation in prostate cancer.
  69. ncbi Sexual function after three-dimensional conformal radiotherapy for prostate cancer: results from a dose-escalation trial
    Gerard J van der Wielen
    Department of Radiation Oncology, Erasmus MC Daniel den Hoed Cancer Center, Rotterdam, The Netherlands
    Int J Radiat Oncol Biol Phys 68:479-84. 2007
    The purpose of this study is to provide information about sexual function (SF) after three-dimensional conformal radiotherapy (3D-CRT) for prostate cancer while taking important factors into account that influence SF.
  70. ncbi A comparison of radiation treatment plans using IMRT with helical tomotherapy and 3D conformal radiotherapy for nasal natural killer/T-cell lymphoma
    N Tomita
    Department of Radiation Oncology, Aichi Cancer Center Hospital, 1 1 Kanokoden, Chikusaku, Nagoya 464 8681, Japan
    Br J Radiol 82:756-63. 2009
    ..In conclusion, 3D-CRT could not provide adequate coverage of the PTV because the PTV was close to many OARs. IMRT should be used for NNKTL because a lack of optimal RTPs could cause local failure...
  71. ncbi High-dose conformal radiotherapy for patients with stage III non-small-cell lung carcinoma
    Hidetsugu Nakayama
    Department of Radiation Oncology, Tsukuba Medical Center, Ibaraki, Japan
    Int J Radiat Oncol Biol Phys 78:645-50. 2010
    To determine the effectiveness of high-dose conformal radiotherapy to the involved field for patients with Stage III non-small-cell lung cancer (NSCLC).
  72. ncbi Dosimetric comparison of IMRT vs. 3D conformal radiotherapy in the treatment of cancer of the cervical esophagus
    Louis Fenkell
    Department of Radiation Oncology, Princess Margaret Hospital, Toronto, ON, Canada
    Radiother Oncol 89:287-91. 2008
    Radiotherapy planning for cervical esophageal cancer is challenging. We compared IMRT and 3D conformal radiotherapy (CRT) with respect to conformality of target coverage and normal tissue sparing.
  73. ncbi Interfraction and respiratory organ motion during conformal radiotherapy in gastric cancer
    Barbara Wysocka
    Department of Radiation Oncology, Princess Margaret Hospital, University of Toronto, Toronto, ON, Canada
    Int J Radiat Oncol Biol Phys 77:53-9. 2010
    ..To quantify the interfraction and breathing organ motion during adjuvant radiotherapy for gastric cancer and assess organ stability in different breathing states...
  74. ncbi Conformal radiotherapy planning of cervix carcinoma: differences in the delineation of the clinical target volume. A comparison between gynaecologic and radiation oncologists
    Elisabeth Weiss
    Department of Radiotherapy, Klinik fur Strahlentherapie, University of Goettingen, Robert Koch Strasse 40, Germany
    Radiother Oncol 67:87-95. 2003
    ..To assess uncertainties in the definition of the clinical target volume (CTV) for patients scheduled for primary radiotherapy of cervix carcinoma...
  75. ncbi Impact of simple tissue inhomogeneity correction algorithms on conformal radiotherapy of lung tumours
    M Engelsman
    Division of Radiotherapy, The Netherlands Cancer Institute, Antoni van Leeuwenhoek Huis, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Radiother Oncol 60:299-309. 2001
    BACKGROUND AND PURPOSE: Conformal radiotherapy requires accurate dose calculation at the dose specification point, at other points in the planning target volume (PTV) and in organs at risk...
  76. ncbi Toxicity of three-dimensional conformal radiotherapy for accelerated partial breast irradiation
    Jaroslaw T Hepel
    Department of Radiation Oncology, Tufts University, Tufts Medical Center, Boston, MA, USA
    Int J Radiat Oncol Biol Phys 75:1290-6. 2009
    To assess the incidence and severity of late normal tissue toxicity using three-dimensional conformal radiotherapy to deliver accelerated partial breast irradiation.
  77. ncbi Comparison of inverse-planned three-dimensional conformal radiotherapy and intensity-modulated radiotherapy for non-small-cell lung cancer
    Judith A Christian
    The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Sutton, United Kingdom
    Int J Radiat Oncol Biol Phys 67:735-41. 2007
    ..This study compared intensity-modulated RT (IMRT) with three-dimensional conformal RT (3D-CRT) in reducing the dose to the lungs...
  78. ncbi Dosimetric comparisons of three-dimensional conformal radiotherapy, intensity-modulated radiotherapy, and helical tomotherapy in whole abdominopelvic radiotherapy for gynecologic malignancy
    Yong Bae Kim
    Department of Radiation Oncology Yonsei Cancer Center, Brain Korea 21 Project for Medical Sciences Yonsei University College of Medicine, Seoul, Korea
    Technol Cancer Res Treat 8:369-77. 2009
    ....
  79. ncbi Recurrences near base of skull after IMRT for head-and-neck cancer: implications for target delineation in high neck and for parotid gland sparing
    Avraham Eisbruch
    Department of Radiation Oncology, University of Michigan, Ann Arbor, MI 48109 0010, USA
    Int J Radiat Oncol Biol Phys 59:28-42. 2004
    ..Locoregional (LR) failures near the base of the skull, and their relationships to the targets in the high neck, were examined in a series of patients who underwent intensity-modulated radiotherapy (IMRT) for head-and-neck cancer...
  80. ncbi Treatment planning comparison between conformal radiotherapy and helical tomotherapy in the case of locally advanced-stage NSCLC
    Giovanni Mauro Cattaneo
    Medical Physics, University of Milano Bicocca, Milano, Italy
    Radiother Oncol 88:310-8. 2008
    To investigate the impact of Helical Tomotherapy (HT) upon the dose distribution when compared to our routinely delivered 3D conformal radiotherapy (CRT) in the case of patients affected by stage III non-small-cell lung cancer (NSCLC).
  81. ncbi A phase I trial of stereotactic body radiation therapy (SBRT) for liver metastases
    Tracey E Schefter
    Department of Radiation Oncology, University of Colorado Health Sciences Center, Aurora, CO 80045 0510, USA
    Int J Radiat Oncol Biol Phys 62:1371-8. 2005
    ..To determine the maximum tolerated dose (MTD) of stereotactic body radiation therapy (SBRT) for liver metastases...
  82. ncbi Internal target volume determined with expansion margins beyond composite gross tumor volume in three-dimensional conformal radiotherapy for lung cancer
    Helen A Shih
    Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Int J Radiat Oncol Biol Phys 60:613-22. 2004
    ....
  83. ncbi A new homogeneity index based on statistical analysis of the dose-volume histogram
    Myonggeun Yoon
    Research Institute and Hospital, National Cancer Center, Goyang, Korea
    J Appl Clin Med Phys 8:9-17. 2007
    ..A guideline for evaluating the dose homogeneity of treatment plans based on the S-index and its relation to equivalent uniform dose is discussed...
  84. ncbi Fractionated stereotactic conformal radiotherapy following conservative surgery in the control of craniopharyngiomas
    Giuseppe Minniti
    Neuro Oncology Unit, The Royal Marsden NHS Foundation Trust, Sutton, Surrey, UK
    Radiother Oncol 82:90-5. 2007
    To describe the technique and results of stereotactically guided conformal radiotherapy (SCRT) in patients with craniopharyngioma after conservative surgery.
  85. pmc Incidence of late rectal bleeding in high-dose conformal radiotherapy of prostate cancer using equivalent uniform dose-based and dose-volume-based normal tissue complication probability models
    Matthias Söhn
    Section for Biomedical Physics, University Hospital for Radiation Oncology, Tubingen, Germany
    Int J Radiat Oncol Biol Phys 67:1066-73. 2007
    ....
  86. ncbi Conformal radiotherapy and intensity-modulated radiotherapy--clinical data
    M Tubiana
    Institut Gustave Roussy, Villejuif, France
    Acta Oncol 39:555-67. 2000
    b>Conformal radiotherapy (CRT) is based on three hypotheses: (i) a higher rate of local control can improve the survival rate; (ii) dose escalation can increase tumor control; and (iii) CRT allows the delivery of higher doses by decreasing ..
  87. ncbi Intensity-modulated radiotherapy versus conventional three-dimensional conformal radiotherapy for boost or salvage treatment of nasopharyngeal carcinoma
    Ching Yeh Hsiung
    Department of Radiation Oncology, Chang Gung Memorial Hospital, 123 Ta Pei Road, Niao Sung Hsian, Kaohsiung Hsien, Taiwan
    Int J Radiat Oncol Biol Phys 53:638-47. 2002
    To compare intensity-modulated radiotherapy (IMRT) and conventional three-dimensional conformal radiotherapy (3D-CRT) for the boost treatment of new-onset nasopharyngeal carcinoma (NPC) or the salvage treatment of locally recurrent NPC.
  88. ncbi Sucralfate versus mesalazine versus hydrocortisone in the prevention of acute radiation proctitis during conformal radiotherapy for prostate carcinoma. A randomized study
    Giuseppe Sanguineti
    Department of Radiation Oncology, National Institute for Cancer Research, Genova, Italy
    Strahlenther Onkol 179:464-70. 2003
    To assess whether the topical use of steroids or 5-aminosalicylic acid (5-ASA) is superior to sucralfate in preventing acute rectal toxicity during three-dimensional conformal radiotherapy (3DCRT) to 76 Gy.
  89. ncbi Has 3-D conformal radiotherapy (3D CRT) improved the local tumour control for stage I non-small cell lung cancer?
    Frank J Lagerwaard
    Department of Radiation Oncology, University Hospital Rotterdam, Groene Hilledijk 301, 3075 EA, Rotterdam, The Netherlands
    Radiother Oncol 63:151-7. 2002
    The high local failure rates observed after radiotherapy in stage I non-small cell lung cancer (NSCLC) may be improved by the use of 3-dimensional conformal radiotherapy (3D CRT).
  90. ncbi Comparison of treatment plans using intensity-modulated radiotherapy and three-dimensional conformal radiotherapy for paranasal sinus carcinoma
    David Huang
    Department of Radiation Oncology, University of California San Francisco, San Francisco, CA, USA
    Int J Radiat Oncol Biol Phys 56:158-68. 2003
    To compare intensity-modulated radiotherapy (IMRT) treatment planning with three-dimensional conformal radiotherapy (3D-CRT) planning for paranasal sinus carcinoma.
  91. ncbi Malignancies of the nasal cavity and paranasal sinuses: long-term outcome with conventional or three-dimensional conformal radiotherapy
    Piet Dirix
    Department of Radiation Oncology, Leuvens Kanker Instituut, University Hospital Gasthuisberg, Leuven, Belgium
    Int J Radiat Oncol Biol Phys 69:1042-50. 2007
    To evaluate the long-term clinical outcome and toxicity of conventional and three-dimensional conformal radiotherapy for malignancies of the nasal cavity and paranasal sinuses.
  92. ncbi The calculated risk of fatal secondary malignancies from intensity-modulated radiation therapy
    Stephen F Kry
    Department of Radiation Physics, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Int J Radiat Oncol Biol Phys 62:1195-203. 2005
    ..Step-and-shoot intensity-modulated radiation therapy (IMRT), an increasingly popular treatment modality, yields higher out-of-field doses than do conventional treatments, because of an increase in required monitor units (beam-on time)...
  93. ncbi Acute and late gastrointestinal toxicity after radiotherapy in prostate cancer patients: consequential late damage
    Wilma D Heemsbergen
    Department of Radiation Oncology, The Netherlands Cancer Institute Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands
    Int J Radiat Oncol Biol Phys 66:3-10. 2006
    ..Late gastrointestinal (GI) toxicity after radiotherapy can be partly explained by late effects of acute toxicity (consequential late damage). We studied whether there is a direct relationship between acute and late GI toxicity...
  94. ncbi Rectal bleeding, fecal incontinence, and high stool frequency after conformal radiotherapy for prostate cancer: normal tissue complication probability modeling
    Stephanie T H Peeters
    Department of Radiation Oncology, The Netherlands Cancer Institute Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands
    Int J Radiat Oncol Biol Phys 66:11-9. 2006
    ..To analyze whether inclusion of predisposing clinical features in the Lyman-Kutcher-Burman (LKB) normal tissue complication probability (NTCP) model improves the estimation of late gastrointestinal toxicity...
  95. ncbi Intensity-modulated radiation therapy for oropharyngeal carcinoma: impact of tumor volume
    K S Clifford Chao
    Department of Radiation Oncology, The University of Texas, M D Anderson Cancer Center, Houston, TX 77030, USA
    Int J Radiat Oncol Biol Phys 59:43-50. 2004
    ....
  96. ncbi Out-of-field photon and neutron dose equivalents from step-and-shoot intensity-modulated radiation therapy
    Stephen F Kry
    Department of Radiation Physics, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Int J Radiat Oncol Biol Phys 62:1204-16. 2005
    ..intensity-modulated radiation therapy [IMRT]) at different treatment energies and delivered by different accelerators...
  97. ncbi High-dose intensity modulated radiation therapy for prostate cancer: early toxicity and biochemical outcome in 772 patients
    Michael J Zelefsky
    Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Int J Radiat Oncol Biol Phys 53:1111-6. 2002
    ..To report the acute and late toxicity and preliminary biochemical outcomes in 772 patients with clinically localized prostate cancer treated with high-dose intensity-modulated radiotherapy (IMRT)...
  98. ncbi High dose radiation delivered by intensity modulated conformal radiotherapy improves the outcome of localized prostate cancer
    M J Zelefsky
    Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    J Urol 166:876-81. 2001
    ..CONCLUSIONS: Sophisticated conformal radiotherapy techniques with high dose 3-D conformal and intensity modulated radiation therapy improve the biochemical ..
  99. ncbi Impact of prolonged fraction delivery times on tumor control: a note of caution for intensity-modulated radiation therapy (IMRT)
    Jian Z Wang
    Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore 21201 1595, USA
    Int J Radiat Oncol Biol Phys 57:543-52. 2003
    ..The purpose of this work is to explore the potential impact of such prolonged fraction delivery times on treatment outcome...
  100. ncbi Predictors of radiation-induced esophageal toxicity in patients with non-small-cell lung cancer treated with three-dimensional conformal radiotherapy
    Anurag K Singh
    Department of Radiation Oncology, Mallinckrodt Institute of Radiology, Siteman Cancer Center, Washington University School of Medicine, St Louis, MO 63110, USA
    Int J Radiat Oncol Biol Phys 55:337-41. 2003
    ..clinical/dosimetric predictors of acute and late Radiation Therapy Oncology Group Grade 3-5 esophageal toxicity in patients with non-small-cell lung cancer (NSCLC) treated with definitive three-dimensional conformal radiotherapy (3D-CRT).
  101. ncbi The risk of early and late lung sequelae after conformal radiotherapy in breast cancer patients
    Zsuzsanna Kahan
    Department of Oncotherapy, University of Szeged, Szeged, Hungary
    Int J Radiat Oncol Biol Phys 68:673-81. 2007
    To study the risks of early and late radiogenic lung damage in breast cancer patients after conformal radiotherapy.

Research Grants64

  1. Targeting Galectin-1 with radiation in lung cancer
    QUYNH THU XUAN LE; Fiscal Year: 2013
    ..Despite dose escalation with conformal radiotherapy (RT), there is still a high intrathoracic failure rate...
  2. Radiotherapy outcomes for children in developing versus developed countries
    Phillip J Taddei; Fiscal Year: 2013
    ..In a virtual clinical trial, quantify the disparity in outcomes of children receiving three-dimensional conformal radiotherapy for a localized brain tumor according to the standard of care in a developing country versus that in a ..
  3. Molecular Gene and Radiation Therapies for Cancer
    SVEND FREYTAG; Fiscal Year: 2009
    ..double suicide gene therapy without (BB-IND 8436) and with (BB-IND 9852) three-dimensional conformal radiotherapy (3D-CRT) in men with prostate cancer have been completed with excellent results...
  4. Small Animal Image-Guided Radiotherapy
    Edward E Graves; Fiscal Year: 2012
    ..The feasibility of laboratory-based conformal radiotherapy has been demonstrated by preliminary investigations in my laboratory in which a variable aperture ..
  5. ONLINE SETUP OF CONFORMAL RADIOTHERAPY USING AMFPIS
    Kwok Lam; Fiscal Year: 2002
    A basic assumption for full realization of conformal radiotherapy (CRT) is that accurate daily patient treatment setup localization and online treatment monitoring leads to improved targeting of tissues tagged for treatment...
  6. TOOLS FOR CONFORMAL RADIOTHERAPY
    Arthur Boyer; Fiscal Year: 1999
    ..from the applicant's abstract): Tools have been developed for planning and delivering intensity-modulated conformal radiotherapy (IMCRT), a variant of new x-ray treatment techniques that use a computer-controlled linear accelerator to ..
  7. PORTAL DOSIMETRY FOR CONFORMAL RADIOTHERAPY
    Yunping Zhu; Fiscal Year: 2000
    ..Pre-treatment verification and on-line checking of patient dose throughout the treatment volume is important especially in conformal radiotherapy.
  8. Development of a Novel X-ray CT-Scannable Dosimeter
    Sai Kumar; Fiscal Year: 2001
    A paramount objective of three-dimensional conformal radiotherapy (3DCRT) is to achieve precise delivery of maximum dose to the target area, white greatly mitigating (if not eliminating) the risk of exposure to adjacent normal body ..
  9. Laser acceleration of protons for radiation therapy
    Dale Litzenberg; Fiscal Year: 2007
    ..This research will conduct the first critical step in determining if the cost can be dramatically reduced through the use of new acceleration technology. [unreadable] [unreadable] [unreadable]..
  10. Dose-Volume Modeling of Late Rectal and Bladder Toxicity
    Susan Tucker; Fiscal Year: 2007
    ..We expect the results of our analyses to play an important role in furthering the development of conformal techniques in RT of the prostate and other pelvic sites. ..
  11. Assessment of BBB Disruption during RT using DCE MRI
    Yue Cao; Fiscal Year: 2006
    ..Data from these scans will be analyzed to quantify vascular permeability, which related to dose, volume, time, and presence in tumor versus normal brain tissue. ..
  12. Early Prediction of Pathological Response of Chemoradiotherapy with FLT PET
    KS CLIFFORD CHAO; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  13. RELEVANCE OF GENOMIC ALTERATIONS IN COLORECTAL CANCER
    Walter Curran; Fiscal Year: 2004
    ..This work will enhance our understanding of the complex events in the MMR-pathway and also provide new diagnostic and prognostic methodologies to test in colorectal tumors. ..
  14. Accurate, easy-to-commission radiotherapy beam models
    Bruce Faddegon; Fiscal Year: 2008
    ..This will allow clinics around the country to take advantage of the computational accuracy of this state-of-the-art clinical tool. [unreadable] [unreadable]..
  15. Xenogen IVIS-200 Bioluminescent Imaging System
    Alan Pollack; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  16. Web-Based Instruction for Medical Dosimetrists
    Paul Keall; Fiscal Year: 2006
    ..abstract_text> ..
  17. HYPOXIC IMAGING GUIDED INTENSITY MODULATED RADIOTHERAPY
    KS CLIFFORD CHAO; Fiscal Year: 2003
    ..They will test the hypothesis by performing multiple Cu-60 ATSM PET scans during the course of irradiation to understand the spatial evolution of hypoxic tumor. ..
  18. Multiattribute decision theory for IMRT plan selection
    Mark Phillips; Fiscal Year: 2009
    ..We will develop and evaluate influence diagrams for prostate cancer and for head &neck cancer. ..
  19. Quantifying Human Lung Tissue Dose Response Relationship
    WALTER O DELL; Fiscal Year: 2008
    ..Our proposal includes graded lung irradiation experiments in animal models to validate and link our imaging results to prior knowledge of cellular and tissue radiobiology. [unreadable] [unreadable] [unreadable]..
  20. An Image Guided Small Animal Radiation Research Platform
    John Wong; Fiscal Year: 2007
    ..The collaborative efforts are best coordinated in a Bioengineering Research Partnership (BRP). An Oversight Group is formed to evaluate the progress of the BRP, and to help identify opportunities and hypotheses for future research. ..
  21. Carbon Nanotube Field Emission Microbeam Array for Single Cell Irradiation
    Sha Chang; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  22. CANCER EDUCATION PROGRAM
    Julia White; Fiscal Year: 2007
    ..Longitudinal tracking of student participants at a later point in their medical training is done to assess the long-term impact of the research experience on career paths. ..
  23. Deformable image registration and reconstruction for radiotherapy applications
    Martin J Murphy; Fiscal Year: 2010
    ..The third aim of the project is to develop measurement and validation procedures to assess the accuracy and reliability of these novel image registration and reconstruction techniques. ..
  24. Gemcitabine-Radiation for Advanced Pancreatic Cancer
    Theodore S Lawrence; Fiscal Year: 2010
    ..We feel our preclinical and clinical team with a track record of 10 years of carrying out leading clinical trials in this area makes it likely that these studies will improve patient outcome. ..
  25. EGFR/Radiation Response and Resistance Interactions
    Paul M Harari; Fiscal Year: 2010
    ..In this research proposal, we seek to increase the percentage of cancer patients who benefit from leading cancer drugs through the identification and disabling of specific tumor cell molecules that promote treatment resistance. ..
  26. Four-dimensional IMAT planning using graph algorithms
    Cedric X Yu; Fiscal Year: 2010
    ..Successful achievement of the aforementioned project aims will provide planning and practical image guidance for the safe and efficient delivery of IMAT, and significantly improve cancer treatments. ..
  27. PSA BASED EARLY DETECTION OF PROSTATE CANCER RECURRENCE
    Jeremy Taylor; Fiscal Year: 2008
    ..abstract_text> ..
  28. Real-Time PDT Dosimetry with Feedback Light Delivery
    Timothy Zhu; Fiscal Year: 2008
    ..abstract_text> ..
  29. NIREP: Non-rigid Image Registration Evaluation Project
    Gary Christensen; Fiscal Year: 2008
    ..3) Disseminate NIREP software and annotated reference databases to the research community. (4) Test performance of major non-rigid image registration algorithms contained in ITK and SPM using the NIREP software. ..
  30. Positron Emission Tomography for Radiation Therapy
    Daniel A Low; Fiscal Year: 2010
    ..This work will provide the radiation-oncology clinician with PET images having unrivaled resolution and sensitivity for target definition, leading to the improved efficacy of radiotherapy in the thoracic and abdominal regions. ..
  31. Better correlation of outcomes with MC dose calculation
    Indrin Chetty; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  32. Image-Guided IMRT for Inter-Fractional Changes
    Radhe Mohan; Fiscal Year: 2008
    ..To accomplish our goal, we intend to leverage the advances we made through our IMRT research in the previous two funding cycles. ..
  33. Digital tomosynthesis: a new paradigm for radiation treatment verification
    Fang Fang Yin; Fiscal Year: 2008
    ..This more frequent and broader range of application will translate into more consistent elimination of tumor and into less damage to nearby healthy tissue. [unreadable] [unreadable] [unreadable]..
  34. NABTC (UCSF PROJECT LEADER) U OF WISCONSIN
    Minesh Mehta; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  35. Experimental Analysis of Advanced Radiotherapy Dosimetry
    JAMES DEMPSEY; Fiscal Year: 2007
    ..Results from this work will provide a paradigm for closing the loop between the clinical treatment planning system and the MLC IMRT delivery system. ..
  36. Indomethacin and p38 Regulating AP-1 In Heat Shock
    Jacob Locke; Fiscal Year: 2004
    ..abstract_text> ..
  37. HIGH-PRECISION IMAGE-GUIDED RADIOTHERAPY OF THE PROSTATE
    David Jaffray; Fiscal Year: 2004
    ..The completion of this system will provide radiation oncologists with the opportunity for unprecedented geometric precision in non-invasive therapy of the prostate. ..
  38. Extracranial Stereotactic Radioablation in Lung Cancer
    Ronald McGarry; Fiscal Year: 2004
    ....
  39. FLAT PANEL CONE BEAM CT FOR IMAGE GUIDED RADIOTHERAPY
    David Jaffray; Fiscal Year: 2004
    ..Successful completion of this program will identify an imaging solution that addresses the clinical need for image-guidance in radiation therapy. ..
  40. TRIMODAL GENE THERAPY FOR PROSTATE CANCER
    SVEND FREYTAG; Fiscal Year: 2003
    ....
  41. FLAT PANEL CONE BEAM CT FOR IMAGE GUIDED RADIOTHERAPY
    David Jaffray; Fiscal Year: 2002
    ..Successful completion of this program will identify an imaging solution that addresses the clinical need for image-guidance in radiation therapy. ..
  42. High Stability Accelerator for Sub-Cellular Microbeam
    David Brenner; Fiscal Year: 2003
    ..We have considerably more demand for microbeam time than we can cope with, primarily because of limited physicist manpower. ..
  43. CANCER AND LEUKEMIA GROUP B
    Martin Edelman; Fiscal Year: 2002
    ..The grant will also allow for continuation of meritorious pilot protocols and will allow GCC to monitor and collect data which will produce mutual benefit to the GCC and CALGB. ..
  44. IMRT FOR GYNECOLOGICAL MALIGNANCIES
    Daniel Low; Fiscal Year: 2002
    ..We believe this novel LACC treatment modality offers the radiation oncologist unparalleled flexibility in dose distribution design, leading to the potential for significant improvement in local control. ..
  45. RADIATION DOSE ESCALATION FOR FOCAL LIVER CANCER
    Theodore Lawrence; Fiscal Year: 2005
    ....
  46. microRT
    Daniel Low; Fiscal Year: 2005
    ..The successful completion of these specific aims will open a new field of preclinical micro imaging-guided radiobiology investigations on small animals. ..
  47. Temporal Variation of Organ Dose Distribution in RT
    Di Yan; Fiscal Year: 2007
    ..Explore practical methods to include temporal variation of organ dose distribution, estimated from image feedback, in treatment planning optimization. ..
  48. Radiotherapy Quality and Outcomes in Prostate Cancer
    JUSTIN BEKELMAN; Fiscal Year: 2006
    ..Furthermore, we hypothesize that higher radiotherapy quality performance is associated with longer event-free survival and lower morbidity. [unreadable] [unreadable] [unreadable]..
  49. Research Center for Emerging Technologies (RCET)
    Jatinder Palta; Fiscal Year: 2006
    ..abstract_text> ..
  50. Improving gene therapy-mediated radiosensitization
    Theodore Lawrence; Fiscal Year: 2006
    ..abstract_text> ..
  51. Cancer Risks Attributable To Radiation from Pediatric CT
    David Brenner; Fiscal Year: 2006
    ..The target audiences will be radiologists, pediatricians, family physicians, and the CT industry. We will use telephone interviews supplemented with survey questions, to aid in web content decisions. ..
  52. Electromagnetic Tracking of Tumors for Radiotherapy
    Martin Murphy; Fiscal Year: 2006
    ..The augmented Calypso targeting system will be designed for integration into existing radiation therapy systems to provide enhanced beam targeting capability. [unreadable] [unreadable]..
  53. Information Processing in Medical Imaging 2005
    Gary Christensen; Fiscal Year: 2005
    ..Women and Minorities are actively encouraged to attend and participate to the fullest extent in the IPMI through the Call for Papers, advertisements, and targeted personal contacts. ..
  54. Intratreatment monitoring of prostate movement during r*
    Howard Sandler; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  55. Real-time in Vivo Dosimetry in Radiation Therapy Using Scintillation Detectors
    Sam Beddar; Fiscal Year: 2009
    ..The resulting data can also be used to study dose- related treatment side effects. The ultimate goal of utilizing this method is to improve the delivery of radiotherapy treatments and the quality of life of radiotherapy patients. ..
  56. Accurate Models for Predicting Radiation-Induced Injury
    Shiva Das; Fiscal Year: 2009
    ..They will be made publicly available via the Internet. The overall impact of this work will be to facilitate significant reduction in thoracic radiotherapy-induced injury via accurate prediction. ..
  57. Hybrid Nuclear/X-ray Projection System for Mouse Imaging
    John Boone; Fiscal Year: 2005
    ..abstract_text> ..
  58. STJUDE PARTICIPATION IN PEDIATRIC BRAIN TUMOR CONSORTIUM
    Larry Kun; Fiscal Year: 2003
    ..The institutional contributions to the PBTCTC combine laboratory and clinical science with a sizable patient base that will be dedicated to consortium trials. ..
  59. Vacsular Remodeling and Effects of Angiogenic Inhibition in Diabetic Retinopathy
    Peter Kaiser; Fiscal Year: 2006
    ..The CAM continues to serve as a convenient testbed for ongoing development of fractal methods and for examination of effects of human regulators on angiogenesis and vascular remodeling. ..
  60. Feasibility of CT in high risk breast cancer patients
    John Boone; Fiscal Year: 2003
    ..The results of this investigation should provide a clear understanding of the potential of breast CT as a tool to reduce breast cancer mortality in the population of women with dire risk of breast cancer. ..
  61. Breast CT scanner for earlier cancer detection
    John Boone; Fiscal Year: 2002
    ..that particularly warrant screening using breast CT. The Phase II trial will shed more light on this issue. ..