brachytherapy

Summary

Summary: A collective term for interstitial, intracavity, and surface radiotherapy. It uses small sealed or partly-sealed sources that may be placed on or near the body surface or within a natural body cavity or implanted directly into the tissues.

Top Publications

  1. ncbi The American Brachytherapy Society recommendations for high-dose-rate brachytherapy for carcinoma of the cervix
    S Nag
    Arthur C James Cancer Hospital, Ohio State University, Columbus, 43210, USA
    Int J Radiat Oncol Biol Phys 48:201-11. 2000
  2. ncbi Quality of life and satisfaction with outcome among prostate-cancer survivors
    Martin G Sanda
    Departments of Surgery, Beth Israel Deaconess Medical Center and Harvard Medical School, Harvard University, Boston, MA 02215, USA
    N Engl J Med 358:1250-61. 2008
  3. ncbi Recommendations from gynaecological (GYN) GEC ESTRO working group (II): concepts and terms in 3D image-based treatment planning in cervix cancer brachytherapy-3D dose volume parameters and aspects of 3D image-based anatomy, radiation physics, radiobiology
    Richard Potter
    Department of Radiotherapy and Radiobiology, Medical University of Vienna, Austria
    Radiother Oncol 78:67-77. 2006
  4. ncbi Update of AAPM Task Group No. 43 Report: A revised AAPM protocol for brachytherapy dose calculations
    Mark J Rivard
    Department of Radiation Oncology, Tufts New England Medical Center, Boston, Massachusetts 02111, USA
    Med Phys 31:633-74. 2004
  5. ncbi Monotherapeutic high-dose-rate brachytherapy for prostate cancer: five-year results of an extreme hypofractionation regimen with 54 Gy in nine fractions
    Yasuo Yoshioka
    Department of Radiation Oncology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Int J Radiat Oncol Biol Phys 80:469-75. 2011
  6. ncbi Recommendations from Gynaecological (GYN) GEC-ESTRO Working Group (I): concepts and terms in 3D image based 3D treatment planning in cervix cancer brachytherapy with emphasis on MRI assessment of GTV and CTV
    Christine Haie-Meder
    Department of Radiotherapy, Brachytherapy Unit, Institut Gustave Roussy, 39 rue Camille Desmoulins, 94805 Villejuif, France
    Radiother Oncol 74:235-45. 2005
  7. ncbi Pelvic radiation with concurrent chemotherapy compared with pelvic and para-aortic radiation for high-risk cervical cancer
    M Morris
    Department of Gynecologic Oncology, University of Texas M D Anderson Cancer Center, Houston 77030, USA
    N Engl J Med 340:1137-43. 1999
  8. pmc Clinical outcome of protocol based image (MRI) guided adaptive brachytherapy combined with 3D conformal radiotherapy with or without chemotherapy in patients with locally advanced cervical cancer
    Richard Potter
    Department of Radiotherapy, Medical University of Vienna, Austria
    Radiother Oncol 100:116-23. 2011
  9. ncbi Virtual HDR CyberKnife treatment for localized prostatic carcinoma: dosimetry comparison with HDR brachytherapy and preliminary clinical observations
    Donald B Fuller
    Radiosurgery Medical Group, Inc, San Diego CyberKnife Center, San Diego, CA 92123, USA
    Int J Radiat Oncol Biol Phys 70:1588-97. 2008
  10. ncbi American Brachytherapy Society consensus guidelines for locally advanced carcinoma of the cervix. Part I: general principles
    Akila N Viswanathan
    Brigham and Women s Hospital and Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Brachytherapy 11:33-46. 2012

Detail Information

Publications320 found, 100 shown here

  1. ncbi The American Brachytherapy Society recommendations for high-dose-rate brachytherapy for carcinoma of the cervix
    S Nag
    Arthur C James Cancer Hospital, Ohio State University, Columbus, 43210, USA
    Int J Radiat Oncol Biol Phys 48:201-11. 2000
    This report presents guidelines for using high-dose-rate (HDR) brachytherapy in the management of patients with cervical cancer, taking into consideration the current availability of resources in most institutions.
  2. ncbi Quality of life and satisfaction with outcome among prostate-cancer survivors
    Martin G Sanda
    Departments of Surgery, Beth Israel Deaconess Medical Center and Harvard Medical School, Harvard University, Boston, MA 02215, USA
    N Engl J Med 358:1250-61. 2008
    ....
  3. ncbi Recommendations from gynaecological (GYN) GEC ESTRO working group (II): concepts and terms in 3D image-based treatment planning in cervix cancer brachytherapy-3D dose volume parameters and aspects of 3D image-based anatomy, radiation physics, radiobiology
    Richard Potter
    Department of Radiotherapy and Radiobiology, Medical University of Vienna, Austria
    Radiother Oncol 78:67-77. 2006
    The second part of the GYN GEC ESTRO working group recommendations is focused on 3D dose-volume parameters for brachytherapy of cervical carcinoma...
  4. ncbi Update of AAPM Task Group No. 43 Report: A revised AAPM protocol for brachytherapy dose calculations
    Mark J Rivard
    Department of Radiation Oncology, Tufts New England Medical Center, Boston, Massachusetts 02111, USA
    Med Phys 31:633-74. 2004
    ..1995 (TG-43), both the utilization of permanent source implantation and the number of low-energy interstitial brachytherapy source models commercially available have dramatically increased...
  5. ncbi Monotherapeutic high-dose-rate brachytherapy for prostate cancer: five-year results of an extreme hypofractionation regimen with 54 Gy in nine fractions
    Yasuo Yoshioka
    Department of Radiation Oncology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Int J Radiat Oncol Biol Phys 80:469-75. 2011
    To evaluate an extreme hypofractionation regimen with 54 Gy in nine fractions provided by high-dose-rate (HDR) brachytherapy as monotherapy for prostate cancer by reporting 5-year clinical results.
  6. ncbi Recommendations from Gynaecological (GYN) GEC-ESTRO Working Group (I): concepts and terms in 3D image based 3D treatment planning in cervix cancer brachytherapy with emphasis on MRI assessment of GTV and CTV
    Christine Haie-Meder
    Department of Radiotherapy, Brachytherapy Unit, Institut Gustave Roussy, 39 rue Camille Desmoulins, 94805 Villejuif, France
    Radiother Oncol 74:235-45. 2005
    b>Brachytherapy (BT) plays a crucial role in the management of invasive cervix cancer from stage I to IV. Intracavitary techniques are based on afterloading devices, with different types of applicators...
  7. ncbi Pelvic radiation with concurrent chemotherapy compared with pelvic and para-aortic radiation for high-risk cervical cancer
    M Morris
    Department of Gynecologic Oncology, University of Texas M D Anderson Cancer Center, Houston 77030, USA
    N Engl J Med 340:1137-43. 1999
    ..Patients were then to receive one or two applications of low-dose-rate intracavitary radiation, with a third cycle of chemotherapy planned for the second intracavitary procedure in the combined-therapy group...
  8. pmc Clinical outcome of protocol based image (MRI) guided adaptive brachytherapy combined with 3D conformal radiotherapy with or without chemotherapy in patients with locally advanced cervical cancer
    Richard Potter
    Department of Radiotherapy, Medical University of Vienna, Austria
    Radiother Oncol 100:116-23. 2011
    To analyse the overall clinical outcome and benefits by applying protocol based image guided adaptive brachytherapy combined with 3D conformal external beam radiotherapy (EBRT)±chemotherapy (ChT).
  9. ncbi Virtual HDR CyberKnife treatment for localized prostatic carcinoma: dosimetry comparison with HDR brachytherapy and preliminary clinical observations
    Donald B Fuller
    Radiosurgery Medical Group, Inc, San Diego CyberKnife Center, San Diego, CA 92123, USA
    Int J Radiat Oncol Biol Phys 70:1588-97. 2008
    ..to approximate the dose (38 Gy), fractionation (four fractions), and distribution of high-dose-rate (HDR) brachytherapy for prostate cancer with CyberKnife (CK) stereotactic body radiotherapy (SBRT) plans...
  10. ncbi American Brachytherapy Society consensus guidelines for locally advanced carcinoma of the cervix. Part I: general principles
    Akila N Viswanathan
    Brigham and Women s Hospital and Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Brachytherapy 11:33-46. 2012
    To develop brachytherapy recommendations covering aspects of pretreatment evaluation, treatment, and dosimetric issues for locally advanced cervical cancer.
  11. ncbi Computed tomography versus magnetic resonance imaging-based contouring in cervical cancer brachytherapy: results of a prospective trial and preliminary guidelines for standardized contours
    Akila N Viswanathan
    Department of Radiation Oncology, Brigham and Women s Hospital, Dana Farber Cancer Institute, Boston, MA, USA
    Int J Radiat Oncol Biol Phys 68:491-8. 2007
    To compare the contours and dose-volume histograms (DVH) of the tumor and organs at risk (OAR) with computed tomography (CT) vs. magnetic resonance imaging (MRI) in cervical cancer brachytherapy.
  12. ncbi High-dose-rate monotherapy: safe and effective brachytherapy for patients with localized prostate cancer
    D Jeffrey Demanes
    California Endocurietherapy at UCLA, Department of Radiation Oncology, David Geffen School of Medicine of the University of California at Los Angeles, Los Angeles, CA 90095, USA
    Int J Radiat Oncol Biol Phys 81:1286-92. 2011
    High-dose-rate (HDR) brachytherapy used as the only treatment (monotherapy) for early prostate cancer is consistent with current concepts in prostate radiobiology, and the dose is reliably delivered in a prospectively defined anatomic ..
  13. ncbi Recommendations for radioembolization of hepatic malignancies using yttrium-90 microsphere brachytherapy: a consensus panel report from the radioembolization brachytherapy oncology consortium
    Andrew Kennedy
    Wake Radiology Oncology, Cary, NC, USA
    Int J Radiat Oncol Biol Phys 68:13-23. 2007
    To standardize the indications, techniques, multimodality treatment approaches, and dosimetry to be used for yttrium-90 (Y90) microsphere hepatic brachytherapy.
  14. ncbi Evaluation of artifacts and distortions of titanium applicators on 3.0-Tesla MRI: feasibility of titanium applicators in MRI-guided brachytherapy for gynecological cancer
    Yusung Kim
    Department of Radiation Oncology, University of Iowa, Iowa City, IA 52242, USA
    Int J Radiat Oncol Biol Phys 80:947-55. 2011
    ..The aim of this study was to characterize the levels of artifacts and distortions of titanium applicators on 3.0-Tesla magnetic resonance imaging (MRI)...
  15. ncbi Multi-institutional analysis of long-term outcome for stages T1-T2 prostate cancer treated with permanent seed implantation
    Michael J Zelefsky
    Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Int J Radiat Oncol Biol Phys 67:327-33. 2007
    To assess long-term prostate-specific antigen (PSA) outcome after permanent prostate brachytherapy (BT) and identify predictors of improved disease-free survival.
  16. ncbi The COMS randomized trial of iodine 125 brachytherapy for choroidal melanoma: IV. Local treatment failure and enucleation in the first 5 years after brachytherapy. COMS report no. 19
    Lee M Jampol
    Department of Ophthalmology, Northwestern University Medical School, Chicago, Illinois, USA
    Ophthalmology 109:2197-206. 2002
    To describe the frequency and predictors of local treatment failure and enucleation after iodine 125 (I(125)) brachytherapy in patients with choroidal melanoma treated and followed up in a large randomized clinical trial.
  17. ncbi Pelvic irradiation with concurrent chemotherapy versus pelvic and para-aortic irradiation for high-risk cervical cancer: an update of radiation therapy oncology group trial (RTOG) 90-01
    Patricia J Eifel
    Department of Radiation Oncology, Unit 97, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    J Clin Oncol 22:872-80. 2004
    ....
  18. ncbi Predictive factors for acute and late urinary toxicity after permanent prostate brachytherapy: long-term outcome in 712 consecutive patients
    Mira Keyes
    Vancouver Cancer Center, Vancouver, BC, Canada
    Int J Radiat Oncol Biol Phys 73:1023-32. 2009
    ..the frequency of acute and late Radiation Therapy Oncology Group (RTOG) urinary toxicity, associated predictive factors, and resolution of International Prostate Symptom Score (IPSS) in 712 consecutive prostate brachytherapy patients.
  19. ncbi Toxicity and early treatment outcomes in low- and intermediate-risk prostate cancer managed by high-dose-rate brachytherapy as a monotherapy
    Pirus Ghadjar
    Department of Radiation Oncology, University of Bern, Inselspital, Bern, Switzerland
    Brachytherapy 8:45-51. 2009
    To determine the acute and late genitourinary (GU) and gastrointestinal (GI) toxicity and present short-term biochemical no evidence of disease (bNED) rates after high-dose-rate brachytherapy (HDR-B) monotherapy.
  20. ncbi High-dose-rate brachytherapy alone for localized prostate cancer in patients at moderate or high risk of biochemical recurrence
    Peter Hoskin
    Cancer Centre, Mount Vernon Hospital, Northwood, Middlesex, UK
    Int J Radiat Oncol Biol Phys 82:1376-84. 2012
    To evaluate genitourinary (GU) and gastrointestinal (GI) morbidity and biochemical control of disease in patients with localized prostate adenocarcinoma treated with escalating doses per fraction of high-dose rate brachytherapy alone.
  21. ncbi Multicenter analysis of effect of high biologic effective dose on biochemical failure and survival outcomes in patients with Gleason score 7-10 prostate cancer treated with permanent prostate brachytherapy
    Nelson N Stone
    Mount Sinai School of Medicine, New York, NY, USA
    Int J Radiat Oncol Biol Phys 73:341-6. 2009
    To investigate the biochemical control rates and survival for Gleason score 7-10 prostate cancer patients undergoing permanent prostate brachytherapy as a function of the biologic effective dose (BED).
  22. pmc High dose rate brachytherapy for oral cancer
    Hideya Yamazaki
    Department of Radiology, Kyoto Prefectural University of Medicine, 465 Kajiicho Kawaramachi Hirokoji, Kamigyo ku, Kyoto 602 8566, Japan
    J Radiat Res 54:1-17. 2013
    b>Brachytherapy results in better dose distribution compared with other treatments because of steep dose reduction in the surrounding normal tissues...
  23. ncbi High-dose-rate interstitial brachytherapy as monotherapy for clinically localized prostate cancer: treatment evolution and mature results
    Nikolaos Zamboglou
    Department of Radiation Oncology, Klinikum Offenbach, Offenbach, Germany
    Int J Radiat Oncol Biol Phys 85:672-8. 2013
    To report the clinical outcome of high-dose-rate (HDR) interstitial (IRT) brachytherapy (BRT) as sole treatment (monotherapy) for clinically localized prostate cancer.
  24. ncbi Direct evidence that prostate tumors show high sensitivity to fractionation (low alpha/beta ratio), similar to late-responding normal tissue
    David J Brenner
    Center for Radiological Research, Department of Radiation Oncology, Columbia University, New York, NY 10032, USA
    Int J Radiat Oncol Biol Phys 52:6-13. 2002
    ..A direct approach to the question of whether prostate tumors have an atypically high sensitivity to fractionation (low alpha/beta ratio), more typical of the surrounding late-responding normal tissue...
  25. ncbi A dose-volume analysis of magnetic resonance imaging-aided high-dose-rate image-based interstitial brachytherapy for uterine cervical cancer
    Ken Yoshida
    Department of Radiology, National Hospital Organization Osaka National Hospital, Osaka, Japan
    Int J Radiat Oncol Biol Phys 77:765-72. 2010
    To investigate the feasibility of our novel image-based high-dose-rate interstitial brachytherapy (HDR-ISBT) for uterine cervical cancer, we evaluated the dose-volume histogram (DVH) according to the recommendations of the Gynecological ..
  26. ncbi High dose brachytherapy as monotherapy for intermediate risk prostate cancer
    C Leland Rogers
    GammaWest Cancer Services, Salt Lake City, Utah, USA
    J Urol 187:109-16. 2012
    We evaluated our retrospective, single institution experience with high dose rate brachytherapy as monotherapy for intermediate risk prostate cancer.
  27. ncbi Brachytherapy reirradiation with hyaluronate gel injection of paraaortic lymphnode metastasis of pancreatic cancer: paravertebral approach--a technical report with a case
    Kazushi Kishi
    Department of Radiation Oncology, Tumor Center, Wakayama Medical University, Wakayama City, 641 8510 Japan
    J Radiat Res 52:840-4. 2011
    ..We developed a new approach and technique of brachytherapy to overcome this difficult situation, with a paravertebral approach and hyaluronate gel injection (HGI)...
  28. ncbi Uncertainties when using only one MRI-based treatment plan for subsequent high-dose-rate tandem and ring applications in brachytherapy of cervix cancer
    Christian Kirisits
    Department of Radiotherapy and Radiobiology, Medical University of Vienna, Vienna, Austria
    Radiother Oncol 81:269-75. 2006
    This retrospective study compares individual MRI based 3D treatment planning for each intracavitary applicator insertion and the use of only one MRI treatment plan for cervical cancer brachytherapy.
  29. ncbi Randomised trial of external beam radiotherapy alone or combined with high-dose-rate brachytherapy boost for localised prostate cancer
    Peter J Hoskin
    Cancer Centre, Mount Vernon Hospital, Northwood, UK
    Radiother Oncol 103:217-22. 2012
    A randomised phase-III trial compared external beam radiotherapy (EBRT) alone with EBRT combined with high-dose-rate brachytherapy boost (HDR-BTb) in localised prostate adenocarcinoma.
  30. ncbi Three-dimensional imaging in gynecologic brachytherapy: a survey of the American Brachytherapy Society
    Akila N Viswanathan
    Department of Radiation Oncology, Brigham and Women s Hospital and Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Int J Radiat Oncol Biol Phys 76:104-9. 2010
    To determine current practice patterns with regard to three-dimensional (3D) imaging for gynecologic brachytherapy among American Brachytherapy Society (ABS) members.
  31. ncbi Comparison of stereotactic brachytherapy (125 iodine seeds) with stereotactic radiosurgery (LINAC) for the treatment of singular cerebral metastases
    Maximilian I Ruge
    Department of Stereotactic and Functional Neurosurgery, University of Cologne, Cologne, Germany
    Strahlenther Onkol 187:7-14. 2011
    To compare stereotactic brachytherapy (SBT) with stereotactic radiosurgery (SRS) for treating singular cerebral metastases, regarding feasibility, complications, cerebral disease control, and survival.
  32. ncbi Surgical resection plus stereotactic 125I brachytherapy in adult patients with eloquently located supratentorial WHO grade II glioma - feasibility and outcome of a combined local treatment concept
    O Schnell
    Department of Neurosurgery, Klinikum Grosshadern, Ludwig Maximilians Universitat Munchen, Marchioninistrasse 15, 81377 Munich, Germany
    J Neurol 255:1495-502. 2008
    ..study analyzed feasibility, risk and effectiveness of 1) microsurgery plus stereotactic iodine-125 ((125)I) brachytherapy (SBT) for large (diameter > 4 cm), circumscribed, and complex located WHO grade II glioma and 2) SBT alone ..
  33. ncbi Comparison of 60cobalt and 192iridium sources in high dose rate afterloading brachytherapy
    Jürgen Richter
    Department of Radiation Oncology, Julius Maximilians University of Wuerzburg, Germany
    Strahlenther Onkol 184:187-92. 2008
    60)Co sources with dimensions identical to those of (192)Ir have recently been made available in clinical brachytherapy. A longer half time reduces demands on logistics and quality assurance and perhaps costs.
  34. ncbi Comparison of intraoperative ultrasound with postimplant computed tomography--dosimetric values at Day 1 and Day 30 after prostate brachytherapy
    Toshio Ohashi
    Department of Radiology, National Hospital Organization Tokyo Medical Center, Tokyo, Japan
    Brachytherapy 6:246-53. 2007
    To compare the results of intraoperative dosimetry with those of postimplant computed tomography (CT)-based dosimetry after (125)I prostate brachytherapy.
  35. ncbi Randomized trial comparing iridium implant plus external-beam radiation therapy with external-beam radiation therapy alone in node-negative locally advanced cancer of the prostate
    Jinka R Sathya
    McMaster University, Hamilton, Ontario, Canada
    J Clin Oncol 23:1192-9. 2005
    ..To determine if iridium implant (IM) and external-beam radiation therapy (EBRT) is better than standard EBRT in locally advanced prostate cancer...
  36. ncbi Comparison of intraoperative dosimetric implant representation with postimplant dosimetry in patients receiving prostate brachytherapy
    Nelson N Stone
    Department of Urology, Mount Sinai School of Medicine, New York, NY, USA
    Brachytherapy 2:17-25. 2003
    ..To compare the results of intraoperative dosimetry with those of CT-based postimplant dosimetry in patients undergoing prostate seed implantation...
  37. ncbi Defining the risk of developing grade 2 proctitis following 125I prostate brachytherapy using a rectal dose-volume histogram analysis
    K M Snyder
    Department of Radiation Oncology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Int J Radiat Oncol Biol Phys 50:335-41. 2001
    ..Delivered dose should be kept below defined rectal volume thresholds to minimize this risk. This information can allow one to decrease rectal morbidity by modifying prostate implant technique...
  38. ncbi Inter- and intraobserver variation in HR-CTV contouring: intercomparison of transverse and paratransverse image orientation in 3D-MRI assisted cervix cancer brachytherapy
    Primoz Petric
    Department of Radiotherapy and Radiobiology, Medical University of Vienna, Vienna, Austria
    Radiother Oncol 89:164-71. 2008
    To analyze agreement between target volumes, delineated by two observers on transverse (T) and paratransverse (perpendicular to the long cervical axis - PT) MR images for cervix cancer brachytherapy.
  39. ncbi The Vienna applicator for combined intracavitary and interstitial brachytherapy of cervical cancer: design, application, treatment planning, and dosimetric results
    Christian Kirisits
    Department of Radiotherapy and Radiobiology, Medical University of Vienna, Vienna, Austria
    Int J Radiat Oncol Biol Phys 65:624-30. 2006
    To present a combined intracavitary and interstitial dedicated applicator and magnetic resonance imaging (MRI) treatment planning for cervical cancer brachytherapy.
  40. ncbi Magnetic resonance image-guided salvage brachytherapy after radiation in select men who initially presented with favorable-risk prostate cancer: a prospective phase 2 study
    Paul L Nguyen
    Department of Radiation Oncology, Brigham and Women s Hospital and Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts
    Cancer 110:1485-92. 2007
    ..evaluated the late gastrointestinal (GI) and genitourinary (GU) toxicity and prostate-specific antigen (PSA) control of magnetic resonance imaging (MRI)-guided brachytherapy used as salvage for radiation therapy (RT) failure.
  41. ncbi Phase II prospective study of the use of conformal high-dose-rate brachytherapy as monotherapy for the treatment of favorable stage prostate cancer: a feasibility report
    A A Martinez
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Int J Radiat Oncol Biol Phys 49:61-9. 2001
    ..the technical feasibility and tolerance of image-guided transperineal conformal high-dose-rate (C-HDR) brachytherapy as the sole treatment modality for favorable, localized cancer of the prostate, and to analyze possible ..
  42. ncbi Potential of dose optimisation in MRI-based PDR brachytherapy of cervix carcinoma
    Marisol De Brabandere
    Department of Radiation Oncology, University Hospital Leuven, Belgium
    Radiother Oncol 88:217-26. 2008
    ..In this study on PDR treatment planning of utero-vaginal carcinoma, we analysed the dosimetry of traditional X-ray based plans as it presents on MR images. The potential gain of MRI-based dose optimisation was assessed...
  43. ncbi Vaginal brachytherapy versus pelvic external beam radiotherapy for patients with endometrial cancer of high-intermediate risk (PORTEC-2): an open-label, non-inferiority, randomised trial
    R A Nout
    Department of Clinical Oncology, Leiden University Medical Center, Leiden, Netherlands
    Lancet 375:816-23. 2010
    ..This study established whether vaginal brachytherapy (VBT) is as effective as pelvic external beam radiotherapy (EBRT) in prevention of vaginal recurrence, with ..
  44. ncbi MRI-based low dose-rate brachytherapy experience in locally advanced cervical cancer patients initially treated by concomitant chemoradiotherapy
    Christine Haie-Meder
    Department of Radiotherapy Brachytherapy Service, Institut Gustave Roussy, Villejuif, France
    Radiother Oncol 96:161-5. 2010
    To retrospectively assess the physics contributions and the clinical outcome with preliminary 3D MRI-guided low dose-rate (LDR) intracavitary brachytherapy (BT) experience in locally advanced cervical cancer patients.
  45. ncbi The evolution of brachytherapy treatment planning
    Mark J Rivard
    Department of Radiation Oncology, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    Med Phys 36:2136-53. 2009
    b>Brachytherapy is a mature treatment modality that has benefited from technological advances. Treatment planning has advanced from simple lookup tables to complex, computer-based dose-calculation algorithms...
  46. ncbi Recommendations from Gynaecological (GYN) GEC-ESTRO Working Group: considerations and pitfalls in commissioning and applicator reconstruction in 3D image-based treatment planning of cervix cancer brachytherapy
    Taran Paulsen Hellebust
    Department of Medical Physics, Division of Cancer and Surgery, Oslo University Hospital, Norway
    Radiother Oncol 96:153-60. 2010
    Image-guided brachytherapy in cervical cancer is increasingly replacing X-ray based dose planning...
  47. ncbi Breast-conserving treatment with partial or whole breast irradiation for low-risk invasive breast carcinoma--5-year results of a randomized trial
    Csaba Polgar
    Department of Radiotherapy, National Institute of Oncology, Budapest, Hungary
    Int J Radiat Oncol Biol Phys 69:694-702. 2007
    ..To report the 5-year results of a randomized study comparing the survival and cosmetic results of breast-conserving treatment with partial breast irradiation (PBI) or conventional whole breast irradiation (WBI)...
  48. ncbi Radiation therapy for choroidal melanoma
    P T Finger
    Department of Ophthalmology, New York Eye and Ear Infirmary, New York, USA
    Surv Ophthalmol 42:215-32. 1997
    ..The most commonly used forms of radiotherapy are ophthalmic plaque brachytherapy and charged-particle (external beam) radiotherapy...
  49. ncbi Impact of 3D image-based PDR brachytherapy on outcome of patients treated for cervix carcinoma in France: results of the French STIC prospective study
    Claire Charra-Brunaud
    Centre Alexis Vautrin, Vandoeuvre les Nancy, France
    Radiother Oncol 103:305-13. 2012
    ..prospective study was initiated to compare two groups of patients treated for cervix carcinoma according to brachytherapy (BT) method: 2D vs 3D dosimetry...
  50. ncbi Uncertainty analysis for 3D image-based cervix cancer brachytherapy by repetitive MR imaging: assessment of DVH-variations between two HDR fractions within one applicator insertion and their clinical relevance
    Stefan Lang
    Department of Radiotherapy, Comprehensive Cancer Center, Medical University of Vienna, Austria
    Radiother Oncol 107:26-31. 2013
    To investigate dosimetric uncertainties of MRI-based cervix cancer brachytherapy, when applying two HDR fractions for each applicator insertion and their clinical relevance.
  51. ncbi Acute genitourinary toxicity after high dose rate (HDR) brachytherapy combined with hypofractionated external-beam radiation therapy for localized prostate cancer: Second analysis to determine the correlation between the urethral dose in HDR brachytherapy
    Tetsuo Akimoto
    Department of Radiation Oncology, Gunma University Graduate School of Medicine, 3 39 22 Showa machi, Maebashi, Gunma 371 8511, Japan
    Int J Radiat Oncol Biol Phys 63:472-8. 2005
    We have been treating localized prostate cancer with high-dose-rate (HDR) brachytherapy combined with hypofractionated external beam radiation therapy (EBRT) at our institution...
  52. ncbi Long-term results of high-dose rate intracavitary brachytherapy for squamous cell carcinoma of the uterine cervix
    Takashi Nakano
    Department of Radiology and Radiation Oncology, Gunma University Graduate School of Medicine, Gunma, Japan
    Cancer 103:92-101. 2005
    The authors performed a long-term follow-up study to evaluate the efficacy and late toxicity of high-dose rate intracavitary brachytherapy (HDR-ICBT) for cervical carcinoma.
  53. ncbi Combination external beam radiotherapy and high-dose-rate intracavitary brachytherapy for uterine cervical cancer: analysis of dose and fractionation schedule
    Takafumi Toita
    Department of Radiology, University of the Ryukyus School of Medicine, Okinawa, Japan
    Int J Radiat Oncol Biol Phys 56:1344-53. 2003
    To determine an appropriate dose and fractionation schedule for a combination of external beam radiotherapy (EBRT) and high-dose-rate intracavitary brachytherapy (HDR-ICBT) for uterine cervical cancer.
  54. pmc Quality of life three years after diagnosis of localised prostate cancer: population based cohort study
    David P Smith
    Cancer Council, Kings Cross, New South Wales 1340, Australia
    BMJ 339:b4817. 2009
    ..To quantify the risk and severity of negative effects of treatment for localised prostate cancer on long term quality of life...
  55. ncbi Clinical impact of MRI assisted dose volume adaptation and dose escalation in brachytherapy of locally advanced cervix cancer
    Richard Potter
    Department of Radiotherapy and Radiobiology, Medical University of Vienna, General Hospital of Vienna, Vienna, Austria
    Radiother Oncol 83:148-55. 2007
    To investigate the clinical impact of MRI based cervix cancer brachytherapy combined with external beam radiochemotherapy applying dose volume adaptation and dose escalation in a consecutive group of patients with locally advanced cervix ..
  56. ncbi Psychological functioning associated with prostate cancer: cross-sectional comparison of patients treated with radiotherapy, brachytherapy, or surgery
    Séverine Hervouet
    School of Psychology, Laval University, Canada
    J Pain Symptom Manage 30:474-84. 2005
    ..and fatigue), and sexual difficulties across three modalities of treatment for prostate cancer (radiotherapy, brachytherapy, and radical prostatectomy)...
  57. ncbi Late genitourinary and gastrointestinal toxicity after magnetic resonance image-guided prostate brachytherapy with or without neoadjuvant external beam radiation therapy
    Michele Albert
    Department of Radiation Oncology, Brigham and Women s Hospital, 75 Francis Street, L 2 Level, Boston, MA 02115, USA
    Cancer 98:949-54. 2003
    This study was designed to estimate the rates of late genitourinary (GU) and rectal toxicity after magnetic resonance image (MRI)-guided prostate brachytherapy exclusively or in conjunction with external beam radiation therapy (EBRT).
  58. ncbi Effectiveness of brachytherapy and fractionated stereotactic radiotherapy boost for persistent nasopharyngeal carcinoma
    Tsz Kok Yau
    Department of Clinical Oncology, Pamela Youde Nethersole Eastern Hospital, 3 Lok Man Road, Chai Wan, Hong Kong
    Head Neck 26:1024-30. 2004
    ..We compared the effectiveness of brachytherapy and a fractionated stereotactic radiotherapy (SRT) boost in improving tumor control.
  59. ncbi Urinary symptom flare in 712 125I prostate brachytherapy patients: long-term follow-up
    Mira Keyes
    Department of Surgery, University of British Columbia, Provincial Prostate Brachytherapy Program, British Columbia Cancer Agency, 600 W 10th Avenue, Vancouver, BC, Canada
    Int J Radiat Oncol Biol Phys 75:649-55. 2009
    ..the late transient worsening of urinary symptoms ("urinary symptom flare") in 712 consecutive prostate brachytherapy patients, associated predictive factors, association with rectal and urinary toxicity, and the development of ..
  60. pmc Value of diffusion weighted MR imaging as an early surrogate parameter for evaluation of tumor response to high-dose-rate brachytherapy of colorectal liver metastases
    Christian Wybranski
    Department of Radiology and Nuclear Medicine, Otto von Guericke University Magdeburg, Germany
    Radiat Oncol 6:43. 2011
    To assess the value of diffusion weighted imaging (DWI) as an early surrogate parameter for treatment response of colorectal liver metastases to image-guided single-fraction ¹⁹²Ir-high-dose-rate brachytherapy (HDR-BT).
  61. ncbi Localization of the surgical bed using supine magnetic resonance and computed tomography scan fusion for planification of breast interstitial brachytherapy
    Marjory Jolicoeur
    Department of Radiotherapy, Hopital Charles LeMoyne, University of Sherbrooke, Quebec, Canada
    Radiother Oncol 100:480-4. 2011
    ..To assess the inter-observer variability of surgical bed delineation on computed tomography (CT) and supine MR...
  62. ncbi High-dose-rate brachytherapy as a monotherapy for favorable-risk prostate cancer: a Phase II trial
    Maroie Barkati
    Division of Radiation Oncology, Peter MacCallum Cancer Centre, East Melbourne, Australia
    Int J Radiat Oncol Biol Phys 82:1889-96. 2012
    There are multiple treatment options for favorable-risk prostate cancer. High-dose-rate (HDR) brachytherapy as a monotherapy is appealing, but its use is still investigational...
  63. ncbi Six-year analysis of treatment-related toxicities in patients treated with accelerated partial breast irradiation on the American Society of Breast Surgeons MammoSite Breast Brachytherapy registry trial
    A J Khan
    Department of Radiation Oncology, Cancer Institute of New Jersey, New Brunswick, NJ, USA
    Ann Surg Oncol 19:1477-83. 2012
    ..The American Society of Breast Surgeons (ASBrS) enrolled women in a registry trial to prospectively study patients treated with the MammoSite RTS device. This report presents 6-year data on treatment-related toxicities from the trial...
  64. ncbi Prostate brachytherapy and second primary cancer risk: a competitive risk analysis
    Karel A Hinnen
    Department of Radiation Oncology, Netherlands Cancer Institute Antoni van Leeuwenhoek Hospital, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    J Clin Oncol 29:4510-5. 2011
    To assess the risk of second primary cancer (SPC) after [(125)I]iodine prostate cancer brachytherapy compared with prostatectomy and the general population.
  65. ncbi Androgen-deprivation therapy does not impact cause-specific or overall survival after permanent prostate brachytherapy
    Gregory S Merrick
    Schiffler Cancer Center, Wheeling Jesuit University, Wheeling, WV, USA
    Int J Radiat Oncol Biol Phys 65:669-77. 2006
    To determine if androgen-deprivation therapy (ADT) has an impact on cause-specific, biochemical progression-free, or overall survival after prostate brachytherapy.
  66. ncbi Acute urinary retention after I-125 prostate brachytherapy in relation to dose in different regions of the prostate
    Ellen M A Roeloffzen
    Department of Radiation Oncology, University Medical Center Utrecht, Utrecht, The Netherlands
    Int J Radiat Oncol Biol Phys 80:76-84. 2011
    To assess the influence of dose in different prostate regions, and the influence of anatomic variation on the risk of acute urinary retention (AUR) after I-125 prostate brachytherapy.
  67. ncbi Daily computed tomography measurement of needle applicator displacement during high-dose-rate interstitial brachytherapy for previously untreated uterine cervical cancer
    Mari Mikami
    Department of Radiology, National Hospital Organization Osaka National Hospital, Osaka, Japan
    Brachytherapy 10:318-24. 2011
    We investigated daily needle applicator displacement during high-dose-rate interstitial brachytherapy.
  68. ncbi The Vienna applicator for combined intracavitary and interstitial brachytherapy of cervical cancer: clinical feasibility and preliminary results
    Johannes C A Dimopoulos
    Department of Radiotherapy and Radiobiology, Medical University of Vienna, Vienna, Austria
    Int J Radiat Oncol Biol Phys 66:83-90. 2006
    ..clinical feasibility and to report on preliminary treatment outcomes of combined intracavitary/interstitial brachytherapy, using a novel applicator and magnetic resonance imaging (MRI)-based treatment planning in patients with ..
  69. ncbi High-dose-rate interstitial brachytherapy as monotherapy in one fraction and transperineal hyaluronic acid injection into the perirectal fat for the treatment of favorable stage prostate cancer: treatment description and preliminary results
    Pedro J Prada
    Department of Radiation Oncology, Hospital Universitario Central de Asturias, Oviedo, Spain
    Brachytherapy 11:105-10. 2012
    ..acute and late genitourinary (GU) toxicity, and gastrointestinal toxicity after high-dose-rate (HDR) brachytherapy as monotherapy in one fraction with transperineal hyaluronic acid injection into the perirectal fat to ..
  70. ncbi Surgical salvage of persistent or recurrent nasopharyngeal carcinoma with maxillary swing approach - Critical appraisal after 2 decades
    William I Wei
    Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong Special Administrative Region, China
    Head Neck 33:969-75. 2011
    ..The purpose of this study was to report on our experience on salvage nasopharyngectomy using the maxillary swing approach for persistent or recurrent nasopharyngeal carcinoma after primary treatment...
  71. ncbi Correlation of dose-volume parameters, endoscopic and clinical rectal side effects in cervix cancer patients treated with definitive radiotherapy including MRI-based brachytherapy
    Petra Georg
    Department of Radiotherapy, Medical University Vienna, Vienna, Austria
    Radiother Oncol 91:173-80. 2009
    ..Correlation of dosimetric parameters for MRI-based 3D treatment planning with rectoscopic findings and clinical rectal side effects...
  72. ncbi A Phase II study of high-dose-rate afterloading brachytherapy as monotherapy for the treatment of localized prostate cancer
    Carie Corner
    Mount Vernon Cancer Centre, Mount Vernon Hospital, Northwood, Middlesex, UK
    Int J Radiat Oncol Biol Phys 72:441-6. 2008
    A Phase II dose escalation study has been undertaken to evaluate high-dose-rate brachytherapy (HDRBT) monotherapy for prostate cancer.
  73. ncbi Primary causes of death after permanent prostate brachytherapy
    Nathan Bittner
    Department of Radiation Oncology, University of Washington, Seattle, WA 26003 6300, USA
    Int J Radiat Oncol Biol Phys 72:433-40. 2008
    To evaluate the primary causes of death in low-risk (low-risk), intermediate-risk (intermediate-risk), and high-risk (high-risk) patients undergoing permanent prostate brachytherapy with or without supplemental therapies.
  74. ncbi Clinical outcomes of high-dose-rate brachytherapy and external beam radiotherapy in the management of clinically localized prostate cancer
    Rupesh Kotecha
    Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Brachytherapy 12:44-9. 2013
    ..antigen (PSA) relapse-free survival and treatment-related toxicity outcomes after combining high-dose-rate (HDR) brachytherapy with external beam radiotherapy (EBRT) for patients with clinically localized prostate cancer.
  75. ncbi High-dose-rate prostate brachytherapy: an excellent accelerated-hypofractionated treatment for favorable prostate cancer
    Alvaro A Martinez
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Am J Clin Oncol 33:481-8. 2010
    ..The 5-year experience at William Beaumont Hospital (WBH) and the California Endocurietherapy Center (CET) with accelerated-hypofractionated high-dose-rate (HDR) monotherapy in favorable prostate cancer is presented...
  76. pmc Recommendations from Gynaecological (GYN) GEC-ESTRO Working Group (IV): Basic principles and parameters for MR imaging within the frame of image based adaptive cervix cancer brachytherapy
    Johannes C A Dimopoulos
    Metropolitan Hospital, Athens, Greece
    Radiother Oncol 103:113-22. 2012
    ..and highlighted the pivotal role of MRI for the successful implementation of 3D image-based cervical cancer brachytherapy (BT). The main advantage of MRI as an imaging modality is its superior soft tissue depiction quality...
  77. ncbi Dose escalation using conformal high-dose-rate brachytherapy improves outcome in unfavorable prostate cancer
    Alvaro A Martinez
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Int J Radiat Oncol Biol Phys 53:316-27. 2002
    ..radioresistance for patients with unfavorable prostate cancer, a prospective trial of pelvic external beam irradiation (EBRT) interdigitated with dose-escalating conformal high-dose-rate (HDR) prostate brachytherapy was performed.
  78. pmc American Brachytherapy Society consensus guidelines for locally advanced carcinoma of the cervix. Part II: high-dose-rate brachytherapy
    Akila N Viswanathan
    Department of Radiation Oncology, Brigham and Women s Hospital and Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Brachytherapy 11:47-52. 2012
    This report presents an update to the American Brachytherapy Society (ABS) high-dose-rate (HDR) brachytherapy guidelines for locally advanced cervical cancer.
  79. ncbi High-dose-rate interstitial brachytherapy as a monotherapy for localized prostate cancer: treatment description and preliminary results of a phase I/II clinical trial
    Y Yoshioka
    Division of Multidisciplinary Radiotherapy, Biomedical Research Center, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Int J Radiat Oncol Biol Phys 48:675-81. 2000
    To improve results for localized prostate cancer, a prospective clinical trial of hyperfractionated Iridium-192 high-dose-rate (HDR) brachytherapy as a monotherapy was initiated.
  80. ncbi Intracavitary combined with CT-guided interstitial brachytherapy for locally advanced uterine cervical cancer: introduction of the technique and a case presentation
    Masaru Wakatsuki
    Department of Radiation Oncology, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan
    J Radiat Res 52:54-8. 2011
    We report a new technique of brachytherapy consisting of intracavitary combined with computed tomography (CT)-guided interstitial brachytherapy for locally advanced cervical cancer...
  81. pmc A dosimetric uncertainty analysis for photon-emitting brachytherapy sources: report of AAPM Task Group No. 138 and GEC-ESTRO
    Larry A DeWerd
    Department of Medical Physics and Accredited Dosimetry Calibration Laboratory, University of Wisconsin, Madison, Wisconsin 53706, USA
    Med Phys 38:782-801. 2011
    This report addresses uncertainties pertaining to brachytherapy single-source dosimetry preceding clinical use...
  82. ncbi Stereotactic biopsy combined with stereotactic (125)iodine brachytherapy for diagnosis and treatment of locally recurrent single brain metastases
    Maximilian I Ruge
    Department of Stereotactic and Functional Neurosurgery, University Hospital of Cologne, Kerpener Straße 62, 50937 Cologne, Germany
    J Neurooncol 105:109-18. 2011
    This paper reports on stereotactic biopsy combined with stereotactic (125)iodine brachytherapy (SBT) for locally recurrent, previously irradiated cerebral metastases, focusing on feasibility, complications, cerebral disease control, and ..
  83. ncbi 18F-fluorodeoxyglucose positron emisson tomography/computed tomography guided conformal brachytherapy for cervical cancer
    Heerim Nam
    Department of Radiation Oncology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, South Korea
    Int J Radiat Oncol Biol Phys 84:e29-34. 2012
    To evaluate the feasibility of 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT)-guided conformal brachytherapy treatment planning in patients with cervical cancer.
  84. ncbi Patterns of care for brachytherapy in Europe: updated results
    Ferran Guedea
    Department of Radiation Oncology, L Hospitalet de Llobregat, Spain
    Radiother Oncol 97:514-20. 2010
    This descriptive survey evaluated brachytherapy (BT) practices and resources in the European area. This was a follow-up study to the original patterns of care for brachytherapy in Europe (PCBE).
  85. ncbi Technical note: EGSnrc-based dosimetric study of the BEBIG 60Co HDR brachytherapy sources
    T Palani Selvam
    Radiological Physics and Advisory Division, Health, Safety and Environment Group, Bhabha Atomic Research Centre, Mumbai 400094, India
    Med Phys 37:1365-70. 2010
    ..A86 (new) 60Co high dose rate brachytherapy sources in an unbounded liquid water phantom...
  86. ncbi Transperineal injection of hyaluronic acid in anterior perirectal fat to decrease rectal toxicity from radiation delivered with intensity modulated brachytherapy or EBRT for prostate cancer patients
    Pedro J Prada
    Department of Radiation Oncology, Hospital Central de Asturias, Oviedo, Spain
    Int J Radiat Oncol Biol Phys 69:95-102. 2007
    ..We began an investigational trial injecting hyaluronic acid (HA) in the perirectal fat to increase the distance between the prostate and the anterior rectal wall. This is the first report using HA injection in oncology...
  87. ncbi Magnetic resonance imaging-guided intracavitary brachytherapy for cancer of the cervix
    Daniel Zwahlen
    Radiation Medicine Program, Princess Margaret Hospital Ontario Cancer Institute, University Health Network, Toronto, ON, Canada
    Int J Radiat Oncol Biol Phys 74:1157-64. 2009
    To determine the feasibility and benefits of optimized magnetic resonance imaging (MRI)-guided brachytherapy (BT) for cancer of the cervix.
  88. ncbi EGSnrc Monte Carlo calculated dosimetry parameters for 192Ir and 169Yb brachytherapy sources
    R E P Taylor
    Carleton Laboratory for Radiotherapy Physics, Ottawa Carleton Institute of Physics, Carleton University Campus Ottawa, Ontario KIS 5B6, Canada
    Med Phys 35:4933-44. 2008
    ..the results of EGSnrc Monte Carlo calculations of the dose distribution surrounding a high dose rate 169Yb brachytherapy source and 14 high dose rate and pulsed dose rate 192Ir brachytherapy sources...
  89. ncbi Applicator reconstruction and applicator shifts in 3D MR-based PDR brachytherapy of cervical cancer
    Astrid A C De Leeuw
    Department of Radiation Oncology, University Medical Center Utrecht, Utrecht, The Netherlands
    Radiother Oncol 93:341-6. 2009
    To evaluate the methods of applicator reconstruction in 3D MR-based planning for brachytherapy of cervical cancer, and to investigate applicator shifts and changes in DVH parameters during PDR treatment.
  90. ncbi Twelve-year clinical outcomes and patterns of failure with accelerated partial breast irradiation versus whole-breast irradiation: results of a matched-pair analysis
    Chirag Shah
    Department of Radiation Oncology, William Beaumont Hospital, MI, USA
    Radiother Oncol 100:210-4. 2011
    ..To compare 12-year outcomes of accelerated partial breast irradiation (APBI) versus whole-breast irradiation (WBI) in patients treated with breast conservation...
  91. ncbi Consequences of random and systematic reconstruction uncertainties in 3D image based brachytherapy in cervical cancer
    Kari Tanderup
    Department of Oncology, Aarhus University Hospital, Denmark
    Radiother Oncol 89:156-63. 2008
    The purpose of this study was to evaluate the impact of random and systematic applicator reconstruction uncertainties on DVH parameters in brachytherapy for cervical cancer.
  92. ncbi Applicator reconstruction for HDR cervix treatment planning using images from 0.35 T open MR scanner
    Rachel Wills
    Clinical Physics Department, Mount Vernon Cancer Centre, Northwood, UK
    Radiother Oncol 94:346-52. 2010
    ..for imaging soft tissue such as the target volume and critical structures relevant to high dose rate (HDR) brachytherapy of the cervix...
  93. ncbi High dose rate brachytherapy in combination with external beam radiotherapy in the radical treatment of prostate cancer: initial results of a randomised phase three trial
    Peter J Hoskin
    Mount Vernon Cancer Centre, Northwood, Middlesex, UK
    Radiother Oncol 84:114-20. 2007
    ..III trial has compared external beam radiotherapy alone with a dose escalated schedule using high dose rate brachytherapy. Patients with histologically confirmed prostate cancer, no evidence of metastases, a PSA <50, no previous ..
  94. pmc Stereotactic brachytherapy of low-grade cerebral glioma after tumor resection
    Bogdana Suchorska
    Department of Neurosurgery, University Hospital Munich Grosshadern, Ludwig Maximilians University, Munich, Germany
    Neuro Oncol 13:1133-42. 2011
    The purpose of this study was to assess the impact of stereotactic brachytherapy (SBT) on survival time and outcome when applied after resection of low-grade glioma (LGG) of World Health Organization grade II...
  95. ncbi Intravaginal brachytherapy alone for intermediate-risk endometrial cancer
    Kaled M Alektiar
    Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Int J Radiat Oncol Biol Phys 62:111-7. 2005
    ..First, can intravaginal brachytherapy (IVRT) alone substitute for external beam RT but without added morbidity? Second, is the high-risk (HR) ..
  96. ncbi Efficacy of high-dose-rate interstitial brachytherapy in patients with oral tongue carcinoma
    Jose Luis Guinot
    Department of Radiation Oncology, Fundación Instituto Valenciano de Oncología IVO, Valencia, Spain
    Brachytherapy 9:227-34. 2010
    To evaluate the results of high-dose-rate (HDR)-interstitial brachytherapy (ISBT) in oral tongue carcinomas.
  97. ncbi Stereotactic 125iodine brachytherapy for the treatment of singular brain metastases: closing a gap?
    Maximilian I Ruge
    Department of Stereotactic and Functional Neurosurgery, Albertus Magnus University of Cologne, Otto v Guericke University, Magdeburg, Germany
    Neurosurgery 68:1209-18; discussion 1218-9. 2011
    ..Brain metastases represent the most common intracranial tumors and are associated with very poor prognosis...
  98. ncbi Transperineal injection of hyaluronic acid in the anterior perirectal fat to decrease rectal toxicity from radiation delivered with low-dose-rate brachytherapy for prostate cancer patients
    Pedro J Prada
    Department of Radiation Oncology, Hospital Universitario Central de Asturias, Oviedo, Spain
    Brachytherapy 8:210-7. 2009
    ..This is the first article looking at such injections in low-dose-rate brachytherapy patients and subsequent rectal toxicity.
  99. ncbi Radiation complications and tumor control after 125I plaque brachytherapy for ocular melanoma
    Ashley W Jensen
    Department of Radiation Oncology, Mayo Medical School, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Int J Radiat Oncol Biol Phys 63:101-8. 2005
    To determine the outcome of 125I plaque brachytherapy at our institution and identify the risk factors associated with the development of radiation complications, tumor recurrence, and metastasis.
  100. ncbi Effects of bladder distension on organs at risk in 3D image-based planning of intracavitary brachytherapy for cervical cancer
    Robert Y Kim
    Department of Radiation Oncology, University of Alabama Medical Center, Birmingham, AL 35249 6832, USA
    Int J Radiat Oncol Biol Phys 76:485-9. 2010
    To investigate the effects of bladder distension on organs at risk (OARs) in the image-based planning of intracavitary brachytherapy for cervical cancer.
  101. ncbi Outcomes of high dose rate interstitial boost brachytherapy after external beam radiation therapy in head and neck cancer--an Indian (single institutional) learning experience
    Niladri B Patra
    Department of Radiotherapy, Medical College Hospital, Kolkata, India
    Brachytherapy 8:248-54. 2009
    ..to assess efficacy and toxicity associated with external beam radiation therapy (EBRT) and high dose rate (HDR) interstitial Iridium-192 ((192)Ir) brachytherapy for the treatment of squamous carcinoma of the oropharynx and oral cavity.

Research Grants67

  1. A Novel Brachytherapy Agent for GBM
    FRANK CALZONE; Fiscal Year: 2013
    ..t.) or intravenously (i.v.). Brachytherapy for malignant gliomas has been traditionally performed via invasive radioactive probes placed intracranially ..
  2. Fabrication and validation of implantable MRI markers for prostate cancer treatme
    Andrew Bright; Fiscal Year: 2010
    ..applicant): Approximately 60,000 of the 200,000 men diagnosed annually with prostate cancer are treated with brachytherapy. Prostate brachytherapy (PB) is performed using tiny radioactive (0...
  3. Robotic System with Multiplexed DOF Control for Minimally Invasive Interventions
    Peter Kazanzides; Fiscal Year: 2012
    ..g. the pubic arch can obstruct a portion of the prostate in some patients during brachytherapy)...
  4. Prostate Cancer Recovery Enhancement (PROCARE) for African American Men
    Lisa C Campbell; Fiscal Year: 2010
    ..CST in African American prostate cancer survivors who have undergone radiation therapies (for example, brachytherapy)...
  5. Genome-Wide Study to Identify SNPs and CNPs Associated with Radiation Injury
    Barry S Rosenstein; Fiscal Year: 2012
    A subgroup of prostate cancer patients treated with brachytherapy experience radiation-induced injury manifested as either urinary morbidity, proctitis or erectile dysfunction (ED)...
  6. Effectiveness of Early Stage Prostate Cancer Treatment
    MARTIN G contact SANDA; Fiscal Year: 2010
    ..most common contemporary treatments for early stage prostate cancer: prostatectomy, external radiotherapy, and brachytherapy. We propose to address this knowledge gap to facilitate treatment decisions...
  7. Broncho-adventitial Drug Delivery: Paclitaxel for Bronchial Carcinoma
    KIRK SEWARD; Fiscal Year: 2013
    ..radiation therapy, surgical resection, photodynamic therapy (PDT), argon plasma coagulation (APC), brachytherapy, and laser resection...
  8. Prostate Cancer In Vivo Using an Ultra Low Field MRI Device
    CHARLIE DANAHER; Fiscal Year: 2010
    ..of tumors to guide biopsy;and 4) in situ monitoring of focal therapies, such as placement of the seeds during brachytherapy. PUBLIC HEALTH RELEVANCE: The American Cancer Society estimates that nearly 200,000 males will be newly ..
  9. Comparative Effectiveness of Localized Prostate Cancer Treatments (Pilot Study)
    Austin B Frakt; Fiscal Year: 2013
    ..across the main treatment modalities: radical prostatectomy (RP), external beam radiation therapy (EBRT), brachytherapy (BT), and active surveillance (AS)...
  10. Multi-lumen steerable needles for transoral access to lung nodules
    Ron Alterovitz; Fiscal Year: 2013
    ..Once the multi-lumen steerable needles safely reach the nodule, the new device will also be able to deliver local therapy via chemotherapy instillation, ablation, and brachytherapy.
  11. Costs and Complications of Radiotherapy Modalities
    Heather Taffet Gold; Fiscal Year: 2012
    ..the risks, complication rates, and costs of RT and subsequent complications for whole breast RT compared to brachytherapy-based accelerated partial breast RT, a newer form of RT that may be associated with new or increased risks of ..
  12. Training in Radiation Oncology Translational Research
    Ross B Mikkelsen; Fiscal Year: 2011
    ..dosimetry, diagnostic imaging and instrumentation, and mentored research in intensity modulated radiotherapy, brachytherapy and diagnostic imaging...
  13. Walking Forward - American Indian Participation in Cancer Clinical Trials
    Daniel G Petereit; Fiscal Year: 2013
    ..g. NCCTG, RTOG, GOG), Investigator initiated trials such as IMRT and brachytherapy studies will be opened...
  14. Nanoplatform Delivery of MDA-7 and Brachytherapy for Treatment of Brain Tumors
    Michael D Shultz; Fiscal Year: 2013
    ..gene-7/interleukin-24 (MDA- 7) and a [unreadable]-emitter, 177Lu, as the radiotherapeutic agent for brachytherapy. MDA-7 has widespread cancer-specific toxicity and radiosensitization effects, two aspects that provide a ..
  15. Integrated Photoacoustic Ultrasound Real-time Imaging for Brachytherapy Treatment
    Everette C Burdette; Fiscal Year: 2013
    ..Permanent interstitial brachytherapy, the permanent placement of radioactive seeds in the prostate, is widely used in the treatment of prostate ..
  16. Local Radionuclide Delivery to Solid Tumors by Injectible Biopolymer
    Wenge Liu; Fiscal Year: 2013
    ..engineered, nonimmunogenic injectable radionuclide deposition system that is an improvement over current brachytherapy methods. PUBLIC HEALTH RELEVANCE: Cancer is the second leading cause of death in the US...
  17. Intraoperative Dose Visualization using X-Ray and Ultrasound for Prostate Brachyt
    Danny Song; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Brachytherapy is widely utilized in the management of prostate cancer;over 55,000 procedures are performed in the US annually...
  18. Joint Segmentation of MR and CT scans for Gynecologic Cancer Brachytherapy
    Tina Kapur; Fiscal Year: 2012
    ..However, MRI more clearly defines gynecologic tumors, though the application of MRI to gynecologic brachytherapy is in its infancy...
  19. A Novel Dose Calculation Method for Targeted Radionuclide Therapy
    Firas Mourtada; Fiscal Year: 2012
    ..g., for external beam and brachytherapy), in order to aid in trial design and tumor response and toxicity prediction, as well as replace the current, ..
  20. Molecular Imaging Directed, 3D Ultrasound-guided, Biopsy System
    Baowei Fei; Fiscal Year: 2013
    ..If completely developed, the multimodality molecular image-guided system will be able to be used not only for biopsy but also for brachytherapy, radiofrequency thermal ablation, cryotherapy, and photodynamic therapy.
  21. Metallofullerene Nanoplatform for Imaging & Treatment
    Panos Fatouros; Fiscal Year: 2009
    ..in vivo, with Gd for MR imaging, with Tb for fluorescence localization, and with Lu for interstitial molecular brachytherapy. The proposed work brings together a number of innovative strategies to develop a nanotechnology platform for ..
  22. OTHER FUNCTIONS "DEVELOPMENT OF A UNI-DIRECTIONAL BRACHYTHERAPY DEVICE FOR THE T
    KRISTY PEREZ; Fiscal Year: 2012
    ..At present, brachytherapy devices used for lung cancer treatment consist of metal I-125 or Cs-131 seeds, originally designed for ..
  23. Radioactive Stents for Brachytherapy of Esophageal Cancers
    YONGREN BENJAMIN PENG; Fiscal Year: 2013
    ..The Phase II research will begin with in vivo biocompatibility assessment and end with preliminary clinical assessment using the proposed advanced radioactive esophageal stents. ..
  24. Quantitative dual-energy CT imaging for radiation therapy treatment planning
    Jeffrey F Williamson; Fiscal Year: 2013
    ..Project Summary/Abstract Proton-beam therapy (PT) and low-energy (20-60 keV) photon-emitting brachytherapy (LEPBT) are rapidly evolving modalities with high potential for improving radiation therapy clinical outcomes ..
  25. MULTI IMAGER COMPATIBLE ROBOT FOR PROSTATE ACCESS
    Dan Stoianovici; Fiscal Year: 2004
    ..The deliverable is an accurate mechanism for performing precise image-guided procedures such as biopsy, brachytherapy, cryosurgery, hyperthermia, interstitial laser therapy, focused ultrasound and microwaves, chemotherapy, gene ..
  26. Characterizing the DNA methylomes of indolent and aggressive prostate cancers
    ANGELA HSIANG HSIANG TING; Fiscal Year: 2013
    ..biologically indolent cancers to the morbidities of prostate cancer treatments such as radical prostatectomy, brachytherapy, and external beam radiation therapy...
  27. Brachytherapy in situ dose-painting administered via gold-nanoparticle eluters
    Wilfred Ngwa; Fiscal Year: 2013
    ..Research: The overall goal of the proposed research is to develop a new brachytherapy application with in situ dose-painting administered via gold-nanoparticle eluters (BANDAGE) that would ..
  28. MULTI IMAGER COMPATIBLE ROBOT FOR PROSTATE ACCESS
    Dan Stoianovici; Fiscal Year: 2001
    ..The deliverable is an accurate mechanism for performing precise image-guided procedures such as biopsy, brachytherapy, cryosurgery, hyperthermia, interstitial laser therapy, focused ultrasound and microwaves, chemotherapy, gene ..
  29. Combined Intravascular Ultrasound and Photoacoustic Imaging of Atherosclerosis
    Stanislav Y Emelianov; Fiscal Year: 2010
    ..interventions including percutaneous balloon angioplasty, endovascular stenting, ablation/vaporization and brachytherapy. To address this clinical need, we propose to develop an advanced, catheter-based combined ultrasound and ..
  30. Enabling Technologies for MRI-Guided Prostate Interventions
    Clare M Tempany; Fiscal Year: 2013
    ..ultrasound to be used sequentially from baseline imaging through prostate biopsy for diagnosis and treatment (brachytherapy) of prostate cancer...
  31. MR Image Guided Gynecologic Brachytherapy
    Akila Viswanathan; Fiscal Year: 2013
    ..The use of brachytherapy, the placement of radioactive seeds directly into the center of the tumor, after external beam radiation, ..
  32. Personal Patient Profile-Prostate: Testing and Implementation in Health Networks
    Donna L Berry; Fiscal Year: 2013
    ..be treated with one or more modalities including observation alone, surgery, cryosurgery, hormonal therapy, brachytherapy, or external beam radiation therapy...
  33. Visualization and real-time dosimetry for prostate brachytherapy using ultrasound
    Septimiu Salcudean; Fiscal Year: 2007
    ..A widely used curative therapy for prostate cancer is prostate brachytherapy. This treatment involves the permanent placement of radioactive capsules (seeds) in the prostate, in a pattern ..
  34. Randomized Feasibility Study of Dilator Use and an Educational Program to Increas
    Deborah Watkins Bruner; Fiscal Year: 2010
    ..malignancy in the United States, with 68 percent to 83 percent of women (treated with adjuvant vaginal brachytherapy (VBT) for Stage II or III) surviving 5-years...
  35. SUPERHEATED DROP DETECTORS FOR DOSIMETRY IN RADIOTHERAPY
    Ravinder Nath; Fiscal Year: 2001
    ..initial studies opened the way to further developments which will allow benchmark dosimetry measurements for brachytherapy sources and for high-LET particles...
  36. ADVANCED TECHNOLOGY QA CENTER
    Jeff M Michalski; Fiscal Year: 2013
    ..as required to) the current electronic data submission of advanced technology (3DCRT, IMRT, SBRT, and brachytherapy) protocol credentialing and case data, archival storage, and remote QA review process utilizing ATC Method-1 (..
  37. TAS::75 0849::TAS
    SETH HOEDL; Fiscal Year: 2010
    The use of LDR brachytherapy after sub-lobar lung resection is the focus of a phase III NCI sponsored trial...
  38. Ultrasonic Tissue-Typing-Guided Prostate Brachytherapy
    Tian Liu; Fiscal Year: 2010
    ..The UTT 3-D cancer mapping will be incorporated into image guided dose escalation in prostate brachytherapy (seed implant)...
  39. Deformable Image Registration and Reconstruction
    Martin J Murphy; Fiscal Year: 2011
    ..tissue voxels to be tracked through the processes of biological imaging, planning and simulation, delivery of brachytherapy, and administration of each IMRT fraction...
  40. Iodine-125 Peripheral Intravascular Brachytherapy System
    John Munro; Fiscal Year: 2004
    ..Restenosis has been the Achilles heel of PTA. The current research has shown that intravascular brachytherapy using afterloaded 192-Iridium sources has a beneficial effect of the treatment of restenosis in femoral and ..
  41. ENHANCEMENT OF IUDR SENSITIZATION BY LOW ENERGY PHOTONS
    Ravinder Nath; Fiscal Year: 1992
    ..on photon energy and dose rate will be studied in order to evaluate the therapeutic potential of IUdR in brachytherapy. Previous studies indicate that radiosensitization by IUdR can be enhanced substantially through the use of ..
  42. Biomedical Imaging Research Opportunities Workshop
    C Partain; Fiscal Year: 2006
    ..The participating societies include; American Brachytherapy society (ABS), American Institute of Ultrasound in Medicine (ALUM), American Roentgen Ray Society (ARRS), ..
  43. SAMARIUM-145 SOURCES FOR BRACHYTHERAPY
    KRISHNAN SUTHANTHIRAN; Fiscal Year: 1991
    ..ionizing radiation in the form of high energy photons are widely used for treatment of cancer, known as brachytherapy. In this treatment radioactive sources are placed directly in the tumor volume (interstitial brachytherapy) or ..
  44. Computer Directed Photodynamic Therapy of Prostate Ca
    Jerzy Jankun; Fiscal Year: 2005
    ..Treatment of organ confined prostatic cancer includes radical prostatectomy, radiotherapy, brachytherapy and cryosurgical ablation. Results from all these are favorable at least in terms of short outcomes...
  45. Brachytherapy Delivery System for Treatment of Lung Cancer
    John Munro; Fiscal Year: 2009
    This Phase II program intends to continue to develop an improved brachytherapy delivery system for treatment of lung cancer by incorporating radioactive 169Ytterbium sources into surgical staples used in lung resection...
  46. BRACHYTHERAPY DOSIMETRY USING PLASTIC SCINTILLATOR
    Jeffrey Williamson; Fiscal Year: 2001
    Our overall goal is to complete development of a two-dimensional (2D) planar dosimetry system for brachytherapy dose measurement based upon a promising new detector system, plastic scintillator (PS) sheet...
  47. REVERSIBLE GELS FOR DELIVERY OF MEDICAL RADIOISOTOPES
    Anna Gutowska; Fiscal Year: 2000
    ..Very high, localized doses deep within the patient can only be achieved with brachytherapy or direct injection of a suitable radionuclide in a suitable delivery vehicle that would assure localization ..
  48. NOVEL ULTRASONIC IMAGING OF BRACHYTHERAPY SEEDS
    ERNEST FELEPPA; Fiscal Year: 2000
    DESCRIPTION: (Applicant's Description) Current methods of implanting radioactive seeds for brachytherapy of prostate cancer rely upon B-mode imaging for planning the dose and monitoring implantation in the operating room...
  49. POSITRON EMISSION TOMOGRAPHY GUIDED PROSTATE BIOPSY
    David Yun; Fiscal Year: 2004
    ..be applied to specifically image the prostate gland for guiding biopsy and optimizing local treatments such as brachytherapy. These applications can be realized through computer image registration with other diagnostic modalities, ..
  50. Bremsstrahlung Enhanced Vascular Brachytherapy Source
    Stephen Bunker; Fiscal Year: 2001
    ..PROPOSED COMMERCIAL APPLICATION: Not available ..
  51. REAL-TIME DOSE COMPUTATION AND TREATMENT PLANNING
    Sartaj Sahni; Fiscal Year: 2001
    ..computational methods that maximize the computational speed of accurate radiotherapy (external beam as well as brachytherapy) dose calculation algorithms...
  52. REAL-TIME DOSE COMPUTATION AND TREATMENT PLANNING
    Sartaj Sahni; Fiscal Year: 2003
    ..computational methods that maximize the computational speed of accurate radiotherapy (external beam as well as brachytherapy) dose calculation algorithms...
  53. FERROMAGNETIC HYPERTHERMIA & IODINE-125 BRACHYTHERAPY
    Richard Steeves; Fiscal Year: 1992
    ..and radiobiological factors on the thermal enhancement ratio (TER) of ferromagnetic hyperthermia with I-125 brachytherapy for the local control of transplanted neoplasms in rabbits...
  54. C-arm Fluoroscopy for Prostate Brachytherapy
    EVERETTE BURDETTE; Fiscal Year: 2003
    ..With present techniques using transrectal ultrasound guidance for brachytherapy, intra-operative localization of implanted seeds with respect to soft tissue anatomy is still an unsolved ..
  55. IMAGING OF THREE-DIMENSIONAL DOSE DISTRIBUTIONS NMR
    Robert Schulz; Fiscal Year: 1990
    ..produced in anthropomorphic phantoms by x-ray and electron beams (single beams or combinations), and by brachytherapy sources...
  56. PRECLINICAL INTERSTITIAL PHOTODYNAMIC THERAPY RESEARCH
    J Chapman; Fiscal Year: 1992
    ..tumors through interstitial fiber optical elements, by procedures analogous to some interstitial techniques of brachytherapy. A goal of our research is to irradiate tumor volumes with as uniform a photo-dose as possible to effect both ..
  57. Interventional PhotoAcoustic Surgical System (i-PASS)
    Russell H Taylor; Fiscal Year: 2013
    ..in using IOUS in both open and laparoscopic surgery, in providing guidance for biopsies, tumor ablation, brachytherapy, and robotic surgery is growing...
  58. Catheter-Based Ultrasound Hyperthermia System for 3D-Targeted Thermal Therapy
    Chris Diederich; Fiscal Year: 2009
    ..highly-controllable interstitial and endocavity ultrasound heating technology to be integrated with HDR brachytherapy as a means to significantly enhance treatment efficacy of combining hyperthermia with standard radiation and ..
  59. Antioxidant Interactions with Prostate Cancer Treatments
    Kathleen Shiverick; Fiscal Year: 2007
    ..Recent improvements in external beam radiotherapy and interstitial brachytherapy (implantation of radioactive pellets) have made this minimally invasive treatment popular among prostate ..
  60. PATIENT OPTIMIZED BRACHYTHERAPY FOR BREAST CARCINOMA
    Piran Sioshansi; Fiscal Year: 2001
    ..treatment following lumpectomy are external beam therapy and, in certain cases, an additional local dose by brachytherapy. Avoiding local occurrence is, naturally, the primary goal, but cosmesis and patient comfort are of critical ..
  61. HYPERTHERMIA AND BRACHYTHERAPY IN BRAIN TUMOR TREATMENT
    David Roberts; Fiscal Year: 1990
    ..efficacy of treatment of brain tumors using an interstitial microwave antenna array hyperthermia system and brachytherapy. The ability of this system to effectively heat brain tumors will be evaluated as well as the effects of ..
  62. RADIOLOGICAL PHYSICS CENTER
    David S Followill; Fiscal Year: 2013
    ..In order to accomplish this objective, the RPC monitors the basic treatment unit output and brachytherapy source strength, the dosimetry data used by the institution, the calculation algorithms used in treatment ..
  63. ARTIFACT-FREE CT IMAGING FOR RADIOTHERAPY PLANNING
    Jeffrey Williamson; Fiscal Year: 2006
    ..with specific emphasis on imaging in the presence of intracavitary applicators, seeds, and needles used in brachytherapy. We hypothesize that artifact-free image-reconstruction technologies will support sufficiently quantitative CT ..
  64. Imaging & Localizing Device Using the Barkhausen Effect
    John Dicello; Fiscal Year: 2003
    ..Potential devices include Fiducial markers, surgical clips, catheters, and brachytherapy-seeds...
  65. QUALITY RESEARCH IN RADIATION ONCOLOGY: ACR PCS
    JESSE WILSON; Fiscal Year: 2009
    ..technological capabilities for delivering both external beam radiotherapy and high- as well as low-dose rate brachytherapy have advanced rapidly and have entered the national practice...
  66. DOSIMETRIC STUDY FOR INTRAVASCULAR BRACHYTHERAPY
    Sou Tung Chiu Tsao; Fiscal Year: 2000
    Intravascular brachytherapy delivered at the time of angioplasty has been proven to be effective in preventing restenosis induced by interventional recanulazation procedures...
  67. Accelerator-based Neutron Brachytherapy
    RUTH SHEFER; Fiscal Year: 2002
    The development of a novel treatment of head and neck tumors based on fast neuron brachytherapy, with or without dose augmentation by neutron by neutron capture in boron, it is proposed...