Genomes and Genes
Summary: The use of IONIZING RADIATION to treat malignant NEOPLASMS and some benign conditions.
Publications379 found, 100 shown here
- CTCAE v3.0: development of a comprehensive grading system for the adverse effects of cancer treatmentAndy Trotti
H Lee Moffitt Cancer Center at the University of South Florida, Tampa, FL 33612, USA
Semin Radiat Oncol 13:176-81. 2003..This article updates recent progress in the evolution of adverse effects grading systems and reviews the development of CTCAE v3.0...
- A review of update clinical results of carbon ion radiotherapyHirohiko Tsujii
Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba, Japan
Jpn J Clin Oncol 42:670-85. 2012..This is practically an ideal property from the standpoint of cancer radiotherapy. Clinical studies have been carried out in the world to confirm the efficacy of carbon ions against a variety ..
- Postoperative irradiation with or without concomitant chemotherapy for locally advanced head and neck cancerJacques Bernier
Department of Radio Oncology, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland
N Engl J Med 350:1945-52. 2004We compared concomitant cisplatin and irradiation with radiotherapy alone as adjuvant treatment for stage III or IV head and neck cancer.
- Preoperative versus postoperative chemoradiotherapy for rectal cancerRolf Sauer
Department of Radiation Therapy, University of Erlangen, Erlangen, Germany
N Engl J Med 351:1731-40. 2004..In recent years, encouraging results with preoperative radiotherapy have been reported...
- Adjuvant whole-brain radiotherapy versus observation after radiosurgery or surgical resection of one to three cerebral metastases: results of the EORTC 22952-26001 studyMartin Kocher
University of Cologne, Cologne, Germany
J Clin Oncol 29:134-41. 2011This European Organisation for Research and Treatment of Cancer phase III trial assesses whether adjuvant whole-brain radiotherapy (WBRT) increases the duration of functional independence after surgery or radiosurgery of brain metastases.
- Risk-adapted targeted intraoperative radiotherapy versus whole-breast radiotherapy for breast cancer: 5-year results for local control and overall survival from the TARGIT-A randomised trialJayant S Vaidya
Clinical Trials Group, Division of Surgery and Interventional Science, University College London, London, UK Department of Surgery, Royal Free Hospital, London, UK Department of Surgery, Whittington Hopsital, London, UK Electronic address
Lancet 383:603-13. 2014The TARGIT-A trial compared risk-adapted radiotherapy using single-dose targeted intraoperative radiotherapy (TARGIT) versus fractionated external beam radiotherapy (EBRT) for breast cancer...
- Concurrent chemotherapy and radiotherapy for organ preservation in advanced laryngeal cancerArlene A Forastiere
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21231 1000, USA
N Engl J Med 349:2091-8. 2003Induction chemotherapy with cisplatin plus fluorouracil followed by radiotherapy is the standard alternative to total laryngectomy for patients with locally advanced laryngeal cancer...
- Palifermin for oral mucositis after intensive therapy for hematologic cancersRicardo Spielberger
City of Hope National Medical Center, Department of Hematology and Hematopoietic Cell Transplantation and Kaiser Permanente BMT Program, Duarte, Calif 91010, USA
N Engl J Med 351:2590-8. 2004Oral mucositis is a complication of intensive chemotherapy and radiotherapy with no effective treatment...
- Proportion of second cancers attributable to radiotherapy treatment in adults: a cohort study in the US SEER cancer registriesAmy Berrington de Gonzalez
Radiation Epidemiology Branch, National Cancer Institute, Bethesda, MD 20892, USA
Lancet Oncol 12:353-60. 2011..made the long-term risks from treatments more important, including the risk of developing a second cancer after radiotherapy. We aimed to estimate the proportion of second cancers attributable to radiotherapy in adults with data from ..
- Memory function before and after whole brain radiotherapy in patients with and without brain metastasesGrit Welzel
Department of Radiation Oncology, University Medical Center Mannheim, University of Heidelberg, Mannheim, Germany
Int J Radiat Oncol Biol Phys 72:1311-8. 2008To prospectively compare the effect of prophylactic and therapeutic whole brain radiotherapy (WBRT) on memory function in patients with and without brain metastases.
- Hypoxic modification of radiotherapy in squamous cell carcinoma of the head and neck--a systematic review and meta-analysisJens Overgaard
Department of Experimental Clinical Oncology, Aarhus University Hospital, Aarhus, Denmark
Radiother Oncol 100:22-32. 2011The importance of tumour hypoxia for the outcome of radiotherapy has been under investigation for decades...
- Cisplatin and fluorouracil alone or with docetaxel in head and neck cancerMarshall R Posner
Dana Farber Cancer Institute, Boston, MA 02115, USA
N Engl J Med 357:1705-15. 2007....
- Excessive toxicity when treating central tumors in a phase II study of stereotactic body radiation therapy for medically inoperable early-stage lung cancerRobert Timmerman
Department of Radiation Oncology, The University of Texas Southwestern Medical Center, 5801 Forest Park Rd, Dallas, TX 75390 9183, USA
J Clin Oncol 24:4833-9. 2006..Building on a previously reported phase I trial, we carried out a prospective phase II trial using stereotactic body radiation therapy (SBRT) in this population...
- Long-term results of the M. D. Anderson randomized dose-escalation trial for prostate cancerDeborah A Kuban
Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Int J Radiat Oncol Biol Phys 70:67-74. 2008To report the long-term results of a randomized radiotherapy dose escalation trial for prostate cancer.
- Preventing or reducing late side effects of radiation therapy: radiobiology meets molecular pathologySøren M Bentzen
University of Wisconsin School of Medicine and Public Health, Department of Human Oncology, K4 316 Clinical Science Center, 600 Highland Avenue, Madison, Wisconsin 53792, USA
Nat Rev Cancer 6:702-13. 2006..Unfortunately, early and late toxicity limits the deliverable intensity of radiotherapy, and might affect the long-term health-related quality of life of the patient...
- Metastasis after radical prostatectomy or external beam radiotherapy for patients with clinically localized prostate cancer: a comparison of clinical cohorts adjusted for case mixMichael J Zelefsky
Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
J Clin Oncol 28:1508-13. 2010We assessed the effect of radical prostatectomy (RP) and external beam radiotherapy (EBRT) on distant metastases (DM) rates in patients with localized prostate cancer treated with RP or EBRT at a single specialized cancer center.
- The hazard of accelerated tumor clonogen repopulation during radiotherapyH R Withers
Department of Radiation Oncology, Jonsson Comprehensive Cancer Center, UCLA
Acta Oncol 27:131-46. 1988When analysis of results of radiotherapy for nearly 500 patients with oropharyngeal cancer showed evidence for rapid tumor regrowth during extensions of treatment from about 5 weeks to about 8 weeks, we searched the literature on ..
- Radiation injury and neurogenesisMichelle L Monje
Department of Neurosurgery, MSLS P309, MC 5487, Stanford, CA, USA
Curr Opin Neurol 16:129-34. 2003..Children and adults who receive radiotherapy involving the brain frequently experience a progressive cognitive decline...
- Radiotherapy with or without chemotherapy in muscle-invasive bladder cancerNicholas D James
University of Birmingham, School of Cancer Sciences, Edgbaston, Birmingham B15 2TT, United Kingdom
N Engl J Med 366:1477-88. 2012b>Radiotherapy is an alternative to cystectomy in patients with muscle-invasive bladder cancer...
- Dose-response in radiotherapy for localized prostate cancer: results of the Dutch multicenter randomized phase III trial comparing 68 Gy of radiotherapy with 78 GyStephanie T H Peeters
Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands
J Clin Oncol 24:1990-6. 2006To determine whether a dose of 78 Gy improves outcome compared with a conventional dose of 68 Gy for prostate cancer patients treated with three-dimensional conformal radiotherapy.
- Effects of an integrated yoga program in modulating psychological stress and radiation-induced genotoxic stress in breast cancer patients undergoing radiotherapyBirendranath Banerjee
Genome Stability Laboratory, Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
Integr Cancer Ther 6:242-50. 2007..well as depression levels and radiation-induced DNA damage were studied in 68 breast cancer patients undergoing radiotherapy. Two psychological questionnaires--Hospital Anxiety and Depression Scale (HADS) and Perceived Stress Scale (PSS)..
- INT 0123 (Radiation Therapy Oncology Group 94-05) phase III trial of combined-modality therapy for esophageal cancer: high-dose versus standard-dose radiation therapyBruce D Minsky
Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
J Clin Oncol 20:1167-74. 2002..To compare the local/regional control, survival, and toxicity of combined-modality therapy using high-dose (64.8 Gy) versus standard-dose (50.4 Gy) radiation therapy for the treatment of patients with esophageal cancer...
- Radiotherapy and short-term androgen deprivation for localized prostate cancerChristopher U Jones
Radiological Associates of Sacramento, Sacramento, CA 95816, USA
N Engl J Med 365:107-18. 2011It is not known whether short-term androgen-deprivation therapy (ADT) before and during radiotherapy improves cancer control and overall survival among patients with early, localized prostate adenocarcinoma.
- Obesity in adult survivors of childhood acute lymphoblastic leukemia: a report from the Childhood Cancer Survivor StudyKevin C Oeffinger
Department of Family Practice and Community Medicine, University of Texas Southwestern Medical Center at Dallas, 753900 9067, USA
J Clin Oncol 21:1359-65. 2003..To determine whether adult survivors (>or= 18 years of age) of childhood acute lymphoblastic leukemia (ALL) are at increased risk for obesity and to assess patient and treatment variables that influence risk...
- Guidelines for the assessment of oral mucositis in adult chemotherapy, radiotherapy and haematopoietic stem cell transplant patientsBarry Quinn
Royal Marsden School of Cancer Nursing and Rehabilitation, London, UK
Eur J Cancer 44:61-72. 2008Oral mucositis (OM) is a serious consequence of some chemotherapy and radiotherapy regimens. A number of reliable instruments are available to assess OM, but none are universally accepted...
- Three-dimensional intrafractional movement of prostate measured during real-time tumor-tracking radiotherapy in supine and prone treatment positionsKei Kitamura
Department of Radiology, Hokkaido University School of Medicine, Sapporo, Japan
Int J Radiat Oncol Biol Phys 53:1117-23. 2002..To quantify three-dimensional (3D) movement of the prostate gland with the patient in the supine and prone positions and to analyze the movement frequency for each treatment position...
- Dose-response relationship in local radiotherapy for hepatocellular carcinomaHee Chul Park
Department of Radiation Oncology, Brain Korea 21 Project for Medical Science, Seoul, South Korea
Int J Radiat Oncol Biol Phys 54:150-5. 2002Dose escalation using three-dimensional conformal radiotherapy (3D-CRT) is based on the hypothesis that increasing the dose can enhance tumor control...
- Targeting the TGF-beta1 pathway to prevent normal tissue injury after cancer therapyMitchell S Anscher
Department of Radiation Oncology, Virginia Commonwealth University, Richmond, Virginia, USA
Oncologist 15:350-9. 2010....
- Quantification of the relative biological effectiveness for ion beam radiotherapy: direct experimental comparison of proton and carbon ion beams and a novel approach for treatment planningThilo Elsasser
Department of Biophysics, GSI Helmholtz Centre for Heavy Ion Research, Darmstadt, Germany
Int J Radiat Oncol Biol Phys 78:1177-83. 2010....
- Incidence of heart disease in 35,000 women treated with radiotherapy for breast cancer in Denmark and SwedenPaul McGale
Clinical Trial Service Unit, University of Oxford, UK
Radiother Oncol 100:167-75. 2011..To study incidence of radiation-related heart disease in a large population of breast cancer patients followed for up to 30 years...
- Preoperative short-course radiotherapy with delayed surgery in primary rectal cancerD Pettersson
Department of Molecular Medicine and Surgery, Uppsala, Sweden
Br J Surg 99:577-83. 2012Short-course radiotherapy (SRT) with immediate surgery and long-course chemoradiotherapy (CRT) are currently the standard preoperative treatment options for rectal cancer...
- A modified Inflammatory Bowel Disease questionnaire and the Vaizey Incontinence questionnaire are simple ways to identify patients with significant gastrointestinal symptoms after pelvic radiotherapyF A Olopade
Department of Medicine and Therapeutics, Imperial College Faculty of Medicine, Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, UK
Br J Cancer 92:1663-70. 2005After radiotherapy for pelvic cancer, chronic gastrointestinal problems may affect quality of life (QOL) in 6-78% of patients...
- AVAglio: Phase 3 trial of bevacizumab plus temozolomide and radiotherapy in newly diagnosed glioblastoma multiformeO L Chinot
Service de Neuro Oncologie, Centre Hospitalo Universitaire Timone, Universite de la Mediterranee, Marseilles, France
Adv Ther 28:334-40. 2011..We describe the protocol for the AVAglio phase 3 registration trial, which is designed to evaluate the efficacy and safety of combining bevacizumab with standard-of-care therapy in patients with newly diagnosed GBM...
- Feasibility report of image guided stereotactic body radiotherapy (IG-SBRT) with tomotherapy for early stage medically inoperable lung cancer using extreme hypofractionationWes Hodge
Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA
Acta Oncol 45:890-6. 2006..dosimetric aspects, and daily image-guidance capability with megavoltage CT (MVCT) of stereotactic body radiotherapy (SBRT) using helical tomotherapy for medically inoperable T1/2 N0 M0 non-small cell lung cancer...
- Twice-daily compared with once-daily thoracic radiotherapy in limited small-cell lung cancer treated concurrently with cisplatin and etoposideA T Turrisi
Medical University of South Carolina, Charleston 29425, USA
N Engl J Med 340:265-71. 1999For small-cell lung cancer confined to one hemithorax (limited small-cell lung cancer), thoracic radiotherapy improves survival, but the best ways of integrating chemotherapy and thoracic radiotherapy remain unsettled...
- Radiotherapy-related fatigueBarbara Alicja Jereczek-Fossa
Department of Radiotherapy, European Institute of Oncology, Via Ripamonti 435, 20141, Milan, Italy
Crit Rev Oncol Hematol 41:317-25. 2002b>Radiotherapy-induced fatigue is a common early and chronic side-effect of irradiation, reported in up to 80 and 30% of patients during radiation therapy and at follow-up visits, respectively...
- Local radiotherapy for patients with unresectable hepatocellular carcinomaWon Park
Department of Radiation Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea
Int J Radiat Oncol Biol Phys 61:1143-50. 2005To evaluate the response to local radiotherapy (RT) for unresectable hepatocellular carcinoma (HCC) and to analyze the dose-response relationship and the treatment-related morbidities.
- Impact of short-term preoperative radiotherapy on health-related quality of life and sexual functioning in primary rectal cancer: report of a multicenter randomized trialCorrie A M Marijnen
Department of Clinical Oncology, Leiden University Medical Center, K1 P, PO Box 9600, 2300 RC Leiden, The Netherlands
J Clin Oncol 23:1847-58. 2005Few prospective studies have been performed about the impact of preoperative radiotherapy (PRT) or total mesorectal excision (TME) on health-related quality of life (HRQL) and sexual functioning in patients with resectable rectal cancer...
- Radiotherapy dose-volume effects on salivary gland functionJoseph O Deasy
Department of Radiation Oncology, Washington University School of Medicine, St Louis, MO 63110, USA
Int J Radiat Oncol Biol Phys 76:S58-63. 2010Publications relating parotid dose-volume characteristics to radiotherapy-induced salivary toxicity were reviewed. Late salivary dysfunction has been correlated to the mean parotid gland dose, with recovery occurring with time...
- Involved-field radiotherapy is equally effective and less toxic compared with extended-field radiotherapy after four cycles of chemotherapy in patients with early-stage unfavorable Hodgkin's lymphoma: results of the HD8 trial of the German Hodgkin's LymphAndreas Engert
Department I of Internal Medicine, University Hospital Cologne, Cologne 50924, Germany
J Clin Oncol 21:3601-8. 2003To investigate whether radiotherapy can be reduced without loss of efficacy from extended field (EF) to involved field (IF) after four cycles of chemotherapy.
- Extent of MGMT promoter methylation correlates with outcome in glioblastomas given temozolomide and radiotherapyJ Dunn
Department of Surgery and Oncology, School of Cancer Studies, University of Liverpool, Liverpool, UK
Br J Cancer 101:124-31. 2009..In this study, we investigated MGMT promoter methylation in glioblastomas treated with temozolomide and radiotherapy in a single UK treatment centre.
- Treatment outcomes and late complications of 849 patients with nasopharyngeal carcinoma treated with radiotherapy aloneShyh An Yeh
Department of Radiation Oncology, Kaohsiung Chang Gung Memorial Hospital, Taiwan
Int J Radiat Oncol Biol Phys 62:672-9. 2005The objective of this study was to describe the treatment outcomes and treatment-related complications of nasopharyngeal carcinoma (NPC) patients treated with radiotherapy alone.
- Normal tissue reactions to radiotherapy: towards tailoring treatment dose by genotypeGillian C Barnett
Department of Oncology, University of Cambridge, Oncology Centre, Addenbrooke s Hospital, Hills Road, Cambridge CB2 0QQ, UK
Nat Rev Cancer 9:134-42. 2009A key challenge in radiotherapy is to maximize radiation doses to cancer cells while minimizing damage to surrounding healthy tissue...
- Phase I/II study of oncolytic HSV GM-CSF in combination with radiotherapy and cisplatin in untreated stage III/IV squamous cell cancer of the head and neckKevin J Harrington
Institute of Cancer Research, 237 Fulham Road, London, United Kingdom
Clin Cancer Res 16:4005-15. 2010....
- Task Group 142 report: quality assurance of medical acceleratorsEric E Klein
Washington University, St Louis, Missouri, USA
Med Phys 36:4197-212. 2009..For example, machines that are used for radiosurgery treatments or intensity-modulated radiotherapy (IMRT) require different tests and/or tolerances...
- Consensus guidelines for the management of radiation dermatitis and coexisting acne-like rash in patients receiving radiotherapy plus EGFR inhibitors for the treatment of squamous cell carcinoma of the head and neckJ Bernier
Department of Radiation Oncology, Genolier Swiss Medical Network, Genolier, Geneva, Switzerland
Ann Oncol 19:142-9. 2008Radiation dermatitis occurs to some degree in most patients receiving radiotherapy, with or without chemotherapy...
- Cognitive and radiological effects of radiotherapy in patients with low-grade glioma: long-term follow-upLinda Douw
Department of Neurology, VU University Medical Center, Amsterdam, Netherlands
Lancet Neurol 8:810-8. 2009..with low-grade glioma (LGG) a mean of 6 years after diagnosis suggested that the tumour itself, rather than the radiotherapy used to treat it, has the most deleterious effect on cognitive functioning; only high fraction dose ..
- Evaluation of 3'-deoxy-3'-18F-fluorothymidine for monitoring tumor response to radiotherapy and photodynamic therapy in miceMasahiro Sugiyama
Department of Radiology, Hamamatsu University School of Medicine, Hamamatsu, Japan
J Nucl Med 45:1754-8. 20043'-Deoxy-3'-18F-fluorothymidine (18F-FLT) has been suggested as a new PET tracer for imaging tumor proliferation. We investigated the use of 18F-FLT to monitor the response of tumors to radiotherapy and photodynamic therapy (PDT) in mice.
- A phase I study of topical Tempol for the prevention of alopecia induced by whole brain radiotherapyJames M Metz
Department of Radiation Oncology, University of Pennsylvania, Philadelphia 19104 4283, USA
Clin Cancer Res 10:6411-7. 2004..This phase Ib study was designed to evaluate the safety and side effect profile of topical Tempol in patients with brain metastases being treated with whole brain radiotherapy.
- Objective assessment of deformable image registration in radiotherapy: a multi-institution studyRojano Kashani
Department of Radiation Oncology, University of Michigan, Ann Arbor Michigan 48109 0010, USA
Med Phys 35:5944-53. 2008The looming potential of deformable alignment tools to play an integral role in adaptive radiotherapy suggests a need for objective assessment of these complex algorithms...
- Mast cells are an essential component of human radiation proctitis and contribute to experimental colorectal damage in miceKarl Blirando
Laboratory of Radiopathology and Experimental Therapeutics, Institute for Radiological Protection and Nuclear Safety IRSN, Fontenay aux Roses, France
Am J Pathol 178:640-51. 2011..Rectal tissue from patients treated with radiotherapy shows mast cell hyperplasia and activation, suggesting that these cells play a role in the development of ..
- Genetic variants of the nonhomologous end joining gene LIG4 and severe radiation pneumonitis in nonsmall cell lung cancer patients treated with definitive radiotherapyMing Yin
Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
Cancer 118:528-35. 2012..The authors hypothesized that single nucleotide polymorphisms (SNPs) in NHEJ repair genes may affect clinical outcomes in patients with nonsmall cell lung cancer (NSCLC) who receive definitive radio(chemo)therapy...
- CSF1R signaling blockade stanches tumor-infiltrating myeloid cells and improves the efficacy of radiotherapy in prostate cancerJingying Xu
Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90095 1735, USA
Cancer Res 73:2782-94. 2013b>Radiotherapy is used to treat many types of cancer, but many treated patients relapse with local tumor recurrence...
- Comparison of radiotherapy alone with radiotherapy plus hyperthermia in locally advanced pelvic tumours: a prospective, randomised, multicentre trial. Dutch Deep Hyperthermia GroupJ Van der Zee
Subdivision of Hyperthermia, Academic Medical Centre, Amsterdam, The Netherlands
Lancet 355:1119-25. 2000Local-control rates after radiotherapy for locally advanced tumours of the bladder, cervix, and rectum are disappointing. We investigated the effect of adding hyperthermia to standard radiotherapy.
- Effects of radiation on normal tissue: consequences and mechanismsHelen B Stone
Radiation Research Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, NIH, MD 20892 7440, USA
Lancet Oncol 4:529-36. 2003..Treatments that reduce the risk or severity of damage to normal tissue or that facilitate the healing of radiation injury are being developed. These could greatly improve the quality of life of patients treated for cancer...
- Palliation of metastatic bone pain: single fraction versus multifraction radiotherapy--a systematic review of randomised trialsW M Sze
Departament of Clinical Oncology, Pamela Youde Nethersole Eastern Hospital, Chai Wan, Hong Kong, PR China
Clin Oncol (R Coll Radiol) 15:345-52. 2003Recent randomised studies have reported that single fraction radiotherapy is as effective as multifraction radiotherapy in relieving pain caused by bone metastasis...
- Dietary counseling improves patient outcomes: a prospective, randomized, controlled trial in colorectal cancer patients undergoing radiotherapyPaula Ravasco
Unidade de Nutrição e Metabolismo, Instituto de Medicina Molecular, Faculdade de Medicina de Lisboa, Avenida Prof Egas Moniz, 1649 028 Lisboa, Portugal
J Clin Oncol 23:1431-8. 2005To investigate the impact of dietary counseling or nutritional supplements on outcomes in cancer patients: nutritional, morbidity, and quality of life (QoL) during and 3 months after radiotherapy.
- Cancer incidence after localized therapy for prostate cancerKihyuck Moon
Department of Urology, University of Virginia, Charlottesville, Virginia 22908, USA
Cancer 107:991-8. 2006..In this study, the authors examined the size and significance of the observed association between occurrences of secondary cancers 5 years after radiotherapy in a large population of men with incident prostate cancer.
- Cisplatin, fluorouracil, and docetaxel in unresectable head and neck cancerJan B Vermorken
Department of Medical Oncology, Universitair Ziekenhuis Antwerpen, Edegem, Belgium
N Engl J Med 357:1695-704. 2007..We compared TPF with PF as induction chemotherapy in patients with locoregionally advanced, unresectable disease...
- Comparison of 12 deformable registration strategies in adaptive radiation therapy for the treatment of head and neck tumorsPierre Castadot
Department of Radiation Oncology, Universite Catholique de Louvain, St Luc University Hospital, Brussels, Belgium
Radiother Oncol 89:1-12. 2008..shrinkage, and tissue edema induce substantial modification of patient's anatomy during head and neck (HN) radiotherapy (RT) or chemo-radiotherapy...
- Evaluation of nonrigid registration models for interfraction dose accumulation in radiotherapyGuillaume Janssens
Communications and Remote Sensing Laboratory TELE, Universite Catholique de Louvain, 1348 Louvain la Neuve, Belgium
Med Phys 36:4268-76. 2009..For this purpose, the accuracy of nonrigid registration methods is assessed for dose accumulation based on the calculated deformations fields...
- Prolonged expression of the γ-H2AX DNA repair biomarker correlates with excess acute and chronic toxicity from radiotherapy treatmentEmma C Bourton
Brunel Institute of Cancer Genetics and Pharmacogenomics, Brunel University, Uxbridge, Middlesex, UK
Int J Cancer 129:2928-34. 2011The normal tissue tolerance levels to fractionated radiotherapy have been appreciated by a century of careful clinical observations and radiobiological studies in animals...
- Early prediction of response to radiotherapy and androgen-deprivation therapy in prostate cancer by repeated functional MRI: a preclinical studyKathrine Røe
Department of Radiation Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, PO Box 4953 Nydalen, 0424 Oslo, Norway
Radiat Oncol 6:65. 2011..We hypothesized that the combination of several functional parameters increased the predictive power...
- Radiation induced CNS toxicity--molecular and cellular mechanismsC Belka
Department of Radiation Oncology, , Hoppe Seyler Str 3,
Br J Cancer 85:1233-9. 2001b>Radiotherapy of tumours proximal to normal CNS structures is limited by the sensitivity of the normal tissue...
- Late cognitive and radiographic changes related to radiotherapy: initial prospective findingsC L Armstrong
Departments of Neurology, University of Pennsylvania Medical School, Children s Hospital of Philadelphia, PA 19104, USA
Neurology 59:40-8. 2002Assumptions about the damaging effects of radiotherapy (XRT) are based on studies in which total dose, dose fraction, treatment volume, degree of malignancy, chemotherapy, tumor recurrence, and neurologic comorbidity interact with XRT ..
- Cancer risks from medical radiationElaine Ron
Division of Cancer Epidemiology and Genetics, National Cancer Institute, EPS 7048, 6120 Executive Boulevard, Bethesda, MD 20892, USA
Health Phys 85:47-59. 2003..Since then, continual improvements in diagnostic imaging and radiotherapy as well as the aging of our population have led to greater use of medical radiation...
- The use of MRI in planning radiotherapy for gynaecological tumoursI Barillot
Clinique d Oncologie et Radiothérapie, Centre Régional Universitaire de Cancérologie Henry S Kaplan, Hopital Bretonneau, Tours, France
Cancer Imaging 6:100-6. 2006..in radiation treatment of gynaecological malignancies are mainly related to the tumour characteristics and the radiotherapy technique used...
- Increased risk of colon cancer after external radiation therapy for prostate cancerElisabetta Rapiti
Geneva Cancer Registry, Institute for Social and Preventive Medicine, University of Geneva, Geneva, Switzerland
Int J Cancer 123:1141-5. 2008b>Radiotherapy can induce second cancers. Controversies still exist regarding the risk of second malignancies after irradiation for prostate cancer...
- Effectiveness of treatments for metastatic uveal melanomaJames J Augsburger
Department of Ophthalmology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA
Am J Ophthalmol 148:119-27. 2009..To evaluate and comment on published peer-reviewed literature for evidence of effectiveness of treatments for metastatic uveal melanoma...
- Acute toxicity of curative radiotherapy for intermediate- and high-risk localised prostate cancer in the EORTC trial 22991O Matzinger
EORTC Headquarters, Belgium
Eur J Cancer 45:2825-34. 2009This trial randomly assessed short-term adjuvant hormonal therapy added to radiotherapy (RT) for intermediate- and high-risk (UICC 1997 cT2a or cT1b-c with high PSA or Gleason score) localised prostate cancer...
- External beam radiotherapy for prostate cancer: urinary outcomes for men with high International Prostate Symptom Scores (IPSS)Renuka Malik
Department of Radiation and Cellular Oncology, University of Chicago, Chicago, IL 60637, USA
Int J Radiat Oncol Biol Phys 80:1080-6. 2011To report the urinary outcome of men treated for prostate cancer with external beam radiotherapy (EBRT) who have pretreatment obstructive urinary symptoms (International Prostate Symptom Score [IPSS] ≥ 15).
- Late radiation-induced heart disease after radiotherapy. Clinical importance, radiobiological mechanisms and strategies of preventionNicolaus Andratschke
Klinik und Poliklinik für Strahlentherapie und Radiologische Onkologie, Technische Universitat Munchen, Munich, Germany
Radiother Oncol 100:160-6. 2011The clinical importance of radiation-induced heart disease, in particular in post-operative radiotherapy of breast cancer patients, has been recognised only recently...
- Image-guided radiotherapy: has it influenced patient outcomes?Alexis Bujold
Département de Radio oncologie clinique enseignement recherche, Hopital Maisonneuve Rosemont, Universite de Montreal, Montreal, Canada
Semin Radiat Oncol 22:50-61. 2012Cancer control and toxicity outcomes are the mainstay of evidence-based medicine in radiation oncology. However, radiotherapy is an intricate therapy involving numerous processes that need to be executed appropriately in order for the ..
- Radiotherapy in elderly patients with inoperable esophageal cancer. Is there a benefit?R Semrau
Department of Radiation Oncology, University of Cologne, Kerpener Str 62, 50924, Cologne, Germany
Strahlenther Onkol 188:226-32. 2012..was to assess the prognosis of inoperable esophageal cancer patients ≥ 70 years undergoing definitive radiotherapy or radiochemotherapy...
- Association between polymorphisms in the DNA repair genes, XRCC1, APE1, and XPD and acute side effects of radiotherapy in breast cancer patientsJenny Chang-Claude
Division of Clinical Epidemiology and Toxicology, German Cancer Research Center, Heidelberg, Germany
Clin Cancer Res 11:4802-9. 2005..We evaluated the association of six polymorphisms in the DNA repair genes: XRCC1 (Arg194Trp, Arg280His, and Arg399Gln), APE1 (Asp148Glu), and XPD (Lys751Gln and Asp312Asn), with the risk of acute skin reactions following radiotherapy.
- An economic evaluation of cetuximab combined with radiotherapy for patients with locally advanced head and neck cancer in Belgium, France, Italy, Switzerland, and the United KingdomBen Brown
IMS Health, London, UK
Value Health 11:791-9. 2008A phase III randomized trial that compared the combination of cetuximab and radiotherapy to radiotherapy alone in patients with locally advanced squamous cell carcinoma of the head and neck provided a platform for a comprehensive economic ..
- Dose to normal tissues outside the radiation therapy patient's treated volume: a review of different radiation therapy techniquesJames A Purdy
Department of Radiation Oncology, University of California, Davis Medical Center, Sacramento, CA 95816, USA
Health Phys 95:666-76. 2008..Dose distributions for the various CRT techniques and the current status of available data for normal tissues, and whole body dose are reviewed...
- Acute and long-term gastrointestinal consequences of chemotherapyFrederic Di Fiore
Digestive Oncology Unit, University Hospital Gasthuisberg, Herestraat 49, 3000 Leuven, Belgium
Best Pract Res Clin Gastroenterol 23:113-24. 2009..We herein review and discuss the main acute and late gastrointestinal toxicities of chemotherapy and/or radiotherapy for patients with gastrointestinal malignancies.
- Dosimetry for treatment with radiolabelled somatostatin analogues. A reviewM Cremonesi
Medical Physics, European Institute of Oncology, Milan, Italy
Q J Nucl Med Mol Imaging 54:37-51. 2010..Special focus is given on recent improvements and indications for critical organ protection that light up challenging perspectives for PRRT...
- Predictors of weight loss during radiotherapy in patients with stage I or II head and neck cancerAlice Nourissat
Clinical Epidemiology Unit, Laval University Cancer Research Center, Chuq Hotel Dieu de Quebec, Quebec City, Quebec, Canada
Cancer 116:2275-83. 2010The purpose of the study was to identify predictors of weight loss during radiotherapy (RT) in patients with stage I or II head and neck (HN) cancer.
- Ocular ischemic syndrome secondary to carotid artery occlusion as a late complication of radiotherapy of nasopharyngeal carcinomaYamei Tang
Department of Neurology, The Second Affiliated Hospital, Sun Yat Sen University, Guangzhou, Guangdong Province, China
J Neuroophthalmol 30:315-20. 2010..Radiation therapy of the head and neck has a relatively high likelihood of causing vascular stenosis. However, we believe this to be the first reported case of OIS following radiotherapy for nasopharyngeal carcinoma.
- Toxicity at three years with and without irradiation of the internal mammary and medial supraclavicular lymph node chain in stage I to III breast cancer (EORTC trial 22922/10925)Oscar Matzinger
European Organisation for Research and Treatment of Cancer EORTC, Headquarters, Brussels, Belgium
Acta Oncol 49:24-34. 2010..We present the toxicity reported until year 3 after treatment...
- A method to separate the rectum from the prostate during proton beam radiotherapy of prostate cancer patientsUlf Isacsson
Sections of Oncology and Medical Radiation Physics, Department of Oncology, Radiology and Clinical Immunology, Uppsala University Hospital, Uppsala, Sweden
Acta Oncol 49:500-5. 2010..of prostate cancer is increasing, either as a single treatment modality or in combination with conventional radiotherapy. The proximity between prostate (target) and rectum (organ at risk) often leads to a compromise between dose to ..
- A review of the clinical evidence for intensity-modulated radiotherapyJ Staffurth
Cardiff University, Velindre Hospital, Whitchurch, Cardiff, UK
Clin Oncol (R Coll Radiol) 22:643-57. 2010Intensity-modulated radiotherapy (IMRT) is a development of three-dimensional conformal radiotherapy that offers improvements in dosimetry in many clinical scenarios...
- Treatment of patients with atypical meningiomas Simpson grade 4 and 5 with a carbon ion boost in combination with postoperative photon radiotherapy: the MARCIE trialStephanie E Combs
Department of Radiation Oncology, University Hospital of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
BMC Cancer 10:615. 2010..A series or smaller studies has shown that postoperative radiotherapy in this patient population can increase progression-free survival, which translates into increased overall ..
- Skull base chordomas: efficacy of surgery followed by carbon ion radiotherapySatoshi Takahashi
Department of Neurosurgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
Acta Neurochir (Wien) 151:759-69. 2009..We report the effectiveness of combined radical skull base surgery with carbon ion radiotherapy for treating skull base chordomas.
- Effects of pulsed, spatially fractionated, microscopic synchrotron X-ray beams on normal and tumoral brain tissueE Brauer-Krisch
European Synchrotron Radiation Facility, B P 220, 38043 Grenoble, France
Mutat Res 704:160-6. 2010..in the target volume in fractions of seconds, with a sharper penumbra than that produced in conventional radiotherapy. MRT research over the past 20 years has yielded many results from preclinical trials based on different animal ..
- Chromosomal radiosensitivity and acute radiation side effects after radiotherapy in tumour patients--a follow-up studyReinhard Huber
Department of Radiation Cytogenetics, HelmholtzZentrum Muenchen German Research Center for Environmental Health, Neuherberg, Germany
Radiat Oncol 6:32. 2011..are highly interested in optimizing doses especially for patients who tend to suffer from side effects of radiotherapy (RT). It seems to be helpful to identify radiosensitive individuals before RT...
- Second malignant neoplasms and cardiovascular disease following radiotherapyLois B Travis
Rubin Center for Cancer Survivorship and Department of Radiation Oncology, James P Wilmot Cancer Center, University of Rochester Medical Center, 265 Crittenden Blvd, CU 420318, Rochester, NY 14642, USA
J Natl Cancer Inst 104:357-70. 2012..late adverse effects experienced by the growing number of cancer survivors worldwide and are due in part to radiotherapy. The National Council on Radiation Protection and Measurements (NCRP) convened an expert scientific committee ..
- Improvement, clinical course, and quality of life after palliative radiotherapy for recurrent glioblastomaCarsten Nieder
Department of Internal Medicine Oncology and Radiation Oncology Units, Nordlandssykehuset HF, Bodø, Norway
Am J Clin Oncol 31:300-5. 2008..Serious late toxicity was uncommon, especially after conventional treatment and fractionated stereotactic radiotherapy (FSRT)...
- Prognostic significance of mid- and post-ABVD PET imaging in Hodgkin's lymphoma: the importance of involved-field radiotherapyD J Sher
Department of Radiation Oncology, Dana Farber Cancer Institute and Brigham and Women s Hospital, Boston, MA, USA
Ann Oncol 20:1848-53. 2009..in Hodgkin's lymphoma (HL), it is unclear whether patients with 2-[fluorine-18]fluoro-2-deoxy-D-glucose (FDG)-PET positivity during and/or after CT can be rendered disease free with consolidative involved-field radiotherapy (IFRT).
- Dose-volume effects for normal tissues in external radiotherapy: pelvisClaudio Fiorino
Medical Physics Department, San Raffaele Scientific Institute, Milan, Italy
Radiother Oncol 93:153-67. 2009..has become increasingly important, due to the rapidly increasing use of inverse-planned intensity-modulated radiotherapy (IMRT) and the consequent need of a quantitative assessment of dose-volume or biological-based cost functions...
- The radiotherapeutic injury--a complex 'wound'James W Denham
Department of Radiation Oncology, Newcastle Mater Misericordiae Hospital, Newcastle University, Locked Bag 7, Hunter Region Mail Centre, NSW 2310, Newcastle, Australia
Radiother Oncol 63:129-45. 2002..therapy produces a series of repeated insults to tissues that undergo significant changes during the course of radiotherapy. Normal tissue responses are also influenced by rate of dose accumulation and other factors that relate to the ..
- The role of radiotherapy in cancer treatment: estimating optimal utilization from a review of evidence-based clinical guidelinesGeoff Delaney
Collaboration for Cancer Outcomes Research and Evaluation CCORE, Liverpool Hospital, Sydney, Australia
Cancer 104:1129-37. 2005b>Radiotherapy utilization rates for cancer vary widely internationally. It has previously been suggested that approximately 50% of all cancer patients should receive radiation. However, this estimate was not evidence-based...
- Dosimetric verification in participating institutions in a stereotactic body radiotherapy trial for stage I non-small cell lung cancer: Japan clinical oncology group trial (JCOG0403)Teiji Nishio
Radiation Oncology Division, National Cancer Center Hospital East, Kashiwa, Japan
Phys Med Biol 51:5409-17. 2006A multicentre phase II trial of stereotactic body radiotherapy for T1N0M0 non-small cell lung cancer was initiated in Japan as the Japan Clinical Oncology Group trial (JCOG0403)...
- Sensitivity of salivary glands to radiation: from animal models to therapiesO Grundmann
Department of Nutritional Sciences, University of Arizona, 1177 E 4th St, Shantz 421, PO Box 210038, Tucson, AZ 85721, USA
J Dent Res 88:894-903. 2009..Salivary glands are exquisitely sensitive to radiation and display acute and chronic responses to radiotherapy. This review will discuss clinical implications of radiosensitivity in normal salivary glands, compare animal ..
- MGMT promoter methylation is predictive of response to radiotherapy and prognostic in the absence of adjuvant alkylating chemotherapy for glioblastomaAndreana L Rivera
Departments of Pathology and Radiation Oncology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 0097, Houston, TX 77030, USA
Neuro Oncol 12:116-21. 2010..In patients who received radiotherapy alone following resection, methylation of the MGMT promoter correlated with an improved response to ..
- The role of concurrent chemoradiotherapy in the treatment of locoregionally advanced nasopharyngeal carcinoma among endemic population: a meta-analysis of the phase III randomized trialsLi Zhang
Department of Medical Oncology, Sun Yat sen University Cancer Center, 651 Dongfeng Road East, Guangzhou, China
BMC Cancer 10:558. 2010....
- Health outcomes after prostatectomy or radiotherapy for prostate cancer: results from the Prostate Cancer Outcomes StudyA L Potosky
Applied Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, MD 20892 7344, USA
J Natl Cancer Inst 92:1582-92. 2000Radical prostatectomy and external beam radiotherapy are the two major therapeutic options for treating clinically localized prostate cancer...
- Radiotherapy and radiosurgery for benign skull base meningiomasGiuseppe Minniti
Department of Radiotherapy Oncology, Sant Andrea Hospital, University La Sapienza, Rome, Italy
Radiat Oncol 4:42. 2009..New radiation techniques, including stereotactic radiosurgery (SRS), fractionated stereotactic radiotherapy (FSRT), and intensity-modulated radiotherapy (IMRT) have been developed as a more accurate technique of ..
- Randomised trial of standard 2D radiotherapy (RT) versus intensity modulated radiotherapy (IMRT) in patients prescribed breast radiotherapyEllen Donovan
Joint Department of Physics, Royal Marsden Hospital and Institute of Cancer Research, Sutton, Surrey, UK
Radiother Oncol 82:254-64. 2007..for partial volumes receiving >107% of the prescribed dose in a proportion of patients prescribed whole breast radiotherapy after tumour excision of early breast cancer...
- Regulation of epithelial cell homeostasis by actin microfilamentsSeema Khurana; Fiscal Year: 2010..to both the pathogenesis of colorectal cancer as well as its resistance to chemotherapeutic drugs and radiotherapy. An understanding of apoptosis would help enhance normal physiology and ameliorate diseases...
- TIMOTHY L SITA; Fiscal Year: 2016..The standard of care for newly diagnosed GBM is surgical resection followed by adjuvant radiotherapy and temozolomide (TMZ) chemotherapy...
- Ted A Bateman; Fiscal Year: 2015..b>Radiotherapy for soft-tissue tumors in the pelvic region increases hip-fracture risk, resulting in substantial patient ..
- Enhancing radiation and cisplatin HNSCC cell killing by inhibiting mitochondrialLynn Harrison; Fiscal Year: 2013..Early stage disease is treated with surgery or radiotherapy alone, while advanced stage HNSCC is treated with a combination of cisplatin and radiotherapy...
- Contribution of c-Jun N-terminal kinase activity to vestibular schwannoma growthMarlan R Hansen; Fiscal Year: 2013..Microsurgical removal and stereotactic radiosurgery/stereotactic radiotherapy (SRS/SRT) constitute the only current treatments for VSs and often result in deafness, tinnitus, facial ..
- RADIATION-INDUCED THYROID CANCERHeinz Ulrich G Weier; Fiscal Year: 2011..who developed thyroid cancer without prior radiation exposure as well as tumors in adult patients who underwent radiotherapy as children or adults...
- PKC delta and cell renewal in irradiated taste epitheliumMARY ELAINE REYLAND; Fiscal Year: 2012..by applicant): Taste dysfunction, either loss or alteration in sensation, is a common occurrence during radiotherapy for head and neck cancer...
- Mechanism of Irradiation Pulmonary FibrosisJoel S Greenberger; Fiscal Year: 2012..Project Narrative This irradiation application addresses a critical problem in managing the side effects of thoracic radiotherapy for lung and esophagus cancer.
- Inhibition of matrix proteases to sensitize medulloblastoma cells to radiationAndrei L Gartel; Fiscal Year: 2013..of uPAR and MMP-9 by RNAi technology could be a potential therapeutic approach to improve the efficacy of radiotherapy in medulloblastoma patients. Specific Aim 1...
- Edward A Neuwelt; Fiscal Year: 2015..Current treatments for brain metastasis such as radiotherapy with or without chemotherapy have only short- term efficacy...
- QUYNH THU XUAN LE; Fiscal Year: 2016..Despite dose escalation with conformal radiotherapy (RT), there is still a high intrathoracic failure rate...
- Autophagy in Brain TumorJin Ming Yang; Fiscal Year: 2013..As eEF-2 kinase is overexpressed in malignant gliomas, targeting this kinase in combination with chemotherapy, radiotherapy, or other existing treatments to shuttle cells into more reliable and permanent pathways of cell death is an ..
- A Molecular targeting agent for systemic radiotherapy of metastatic Prostate CancKevin P Maresca; Fiscal Year: 2010..This proposal is designed to generate the pre-clinical efficacy data for the corresponding therapeutic I-131-MIP-1072 in order to assess the possibilities of developing the imaging agent into an effective treatment for prostate cancer. ..
- CSHL Eukaryotic DNA Replication ConferenceDavid J Stewart; Fiscal Year: 2013..crucial to cell division, uncontrolled growth is a hallmark of tumors, S phase is a major target for chemo- and radiotherapy and errors in DNA replication lead to genomic instability, the relevance of this meeting to cancer research, ..
- Tousled kinase contributes to survival of salivary acinar cells against radiationGulshan Sunavala-Dossabhoy; Fiscal Year: 2013..Oral complications predominantly affect patients undergoing radiotherapy for head and neck cancers, early stage lymphomas, and full-body radiation before bone marrow transplantation...
- Gutless Adenovirus Mediated Gene Therapy for GliomaMaria G Castro; Fiscal Year: 2011..Mean survival time from the time of diagnosis is 6-12 months, in spite of advances in chemotherapy, surgery and radiotherapy. Harnessing the host's immune system to develop novel treatments for GBM has been attempted...
- Slow cycling brain tumor cancer stem cellsBRENT REYNOLDS; Fiscal Year: 2010..time of less than 1 year despite aggressive therapy that combines state-of- the-art imaging with surgery, radiotherapy and chemotherapy...
- Heat Shock-Induced ApoptosisShawn B Bratton; Fiscal Year: 2012..shock, or hyperthermia, is currently being used in clinical trials, either alone or as an adjunct to chemo- or radiotherapy for the treatment of various cancers. Unfortunately, very little is known about how heat shock kills cells...
- Darell D Bigner; Fiscal Year: 2016..Project 1, led by Michael Zaiutsky, is entitled "Targeted Radiotherapy of Neoplastic Meningitis using Monoclonal Antibodies Labeled with Alpha Particle Emitting At...
- ASCORBATE-INDUCED RADIOSENSITIZATION IN PANCREATIC CANCERJoseph J Cullen; Fiscal Year: 2013..extends this preclinical work to determine if this strategy can be used effectively as an adjuvant in radiotherapy for pancreatic cancer...
- Using Ketogenic Diets to Enhance Radio-Chemo-Therapy Response: A Phase I TrialDOUGLAS ROBERT SPITZ; Fiscal Year: 2012..This is based on preliminary data in mice with human NSCLC or pancreas cancer xenografts fed KD during radiotherapy demonstrate enhanced therapeutic responses and increases in parameters indicative of oxidative stress with no ..
- JOHN P O'BRYAN; Fiscal Year: 2014..b>Radiotherapy remains a major component of treatment modalities for controlling both malignant and benign glioblastomas...
- Martin G Pomper; Fiscal Year: 2014..tumor cells harboring the EBV genome will already possess the TK that we can harness for targeted, enzymatic radiotherapy. Because the substrate specificity for the viral TK is orthogonal to that of cellular TK, we can use a ..
- Genetic Instability &Risk for Esophageal CarcinomaXifeng Wu; Fiscal Year: 2012..We will accrue 600 patients with EAC from M.D. Anderson Cancer Center who have not received chemotherapy or radiotherapy and are residents of Texas...
- Martin G Pomper; Fiscal Year: 2016..mAb) [111In]capromab pendetide (Cyt-356, ProstaScint) is being used to identify candidates for salvage radiotherapy. However, intact antibodies tend to have poor pharmacokinetics for imaging...
- David Kozono; Fiscal Year: 2016..our recently commissioned small animal radiation research platform (SARRP) for CT-guided targeted mouse radiotherapy. Key elements of the career development plan also include courses at the Harvard School of Public Health on ..
- Lung Cancer Chemoradiation: Predictors of SurvivalXifeng Wu; Fiscal Year: 2009..theme of this study is that intrinsic differences in the susceptibility of cells to the genotoxic effects of radiotherapy and chemotherapy modulate toxicity and outcome...
- Soy isoflavones to augment radiotherapy of lung carcinomaGilda G Hillman; Fiscal Year: 2012..provided by applicant): Treatment of unresectable locally advanced non-small cell lung cancer includes radiotherapy which is limited by its toxicity to normal lung, particularly when treating larger-volume disease...
- Bioactive Peptides for Mitigation of AGS and Acute Radiation InjuryLurong Zhang; Fiscal Year: 2010..AGS and ARI, but also be of benefit to millions of cancer patients each year who undergo chemotherapy or radiotherapy which damages the GI and BM systems...
- A phase Ib/II study of AZD2171 and radiation for new brain metastases from NSCLCAPRIL FITZSIMMONS EICHLER; Fiscal Year: 2010..Despite the standard use of whole brain radiotherapy (WBRT), the prognosis of patients with brain metastases remains dismal...
- CAMERON JOHN TURTLE; Fiscal Year: 2015..Inflammation induced by conditioning chemo-radiotherapy prior to HSCT could provide the necessary initiating signals that cause loss of TCR regulation or ..
- Quiescent Tc17 programmed CD8 T cells and their role in graft versus host diseaseCAMERON JOHN TURTLE; Fiscal Year: 2012..Inflammation induced by conditioning chemo-radiotherapy prior to HSCT could provide the necessary initiating signals that cause loss of TCR regulation or ..
- A Novel Therapy for Radiation-Induced Xerostomia Using Human Salivary Stem CellsQUYNH THU XUAN LE; Fiscal Year: 2012..Current pharmacologic management of RT-related xerostomia is costly and ineffective. Intensity modulated radiotherapy (IMRT), which aims to spare one parotid gland, has resulted in some improvement of stimulatory salivary ..
- Linda A Barlow; Fiscal Year: 2016..In particular, head and neck cancer patients receiving radiotherapy virtually always experience loss or distortion of their sense of taste that can persist for years...
- Sandeep Burma; Fiscal Year: 2015..relatively unchanged over the past 40 years despite aggressive therapy that includes surgical resection, radiotherapy and chemotherapy...
- The MRAD9 Radioresistance GeneHoward B Lieberman; Fiscal Year: 2013..impact on a wide array of important issues, including understanding inherent susceptibility to DNA damage, with implications for radiotherapy, as well as the genetic control of sperm development and male infertility.
- Hongbo R Luo; Fiscal Year: 2016Project summary Chemo- and radiotherapy are extensively used to treat various hematological malignancies and solid tumors...
- FOUR-DIMENSIONAL MRI FOR IMAGE-GUIDED RADIATION THERAPY FOR PANCREATIC CANCERYanle Hu; Fiscal Year: 2013..Despite a high tendency for metastatic spread, radiotherapy plays an important role in the management of locally advanced unresectable pancreatic cancer...
- Tej K Pandita; Fiscal Year: 2014..The inability of radiotherapy to control tumor growth is still a daunting clinical problem that leads to the failure of many treatment ..
- Effect of Bone Marrow Cells on the Radiosensitivity of Brain and Mouth CancersJOHN MARTIN BROWN; Fiscal Year: 2012..of glioblastoma multiforme (GBM) and of head and neck tumors: human cancers for which the current treatment is radiotherapy (with or without surgery and chemotherapy) and for which treatment failure leading to patient death is largely ..
- IVETTE SUAREZ; Fiscal Year: 2015..Since IBC tumor cell emboli are more efficient at forming metastases and are more resistant to chemo and radiotherapy than single cells, it seems feasible to prevent IBC with a compound that has the ability to disintegrate the ..
- Antimicrobial and Regenerative Treatment for Oral MucositisSHENDA BAKER; Fiscal Year: 2012DESCRIPTION (provided by applicant): Oral mucositis is a frequent and painful complication of chemotherapy, radiotherapy and immune compromise...
- Discovering Microenvironments Promoting Pathological EMT using Array TechnologyNaira Serobyan; Fiscal Year: 2012..Current conventional therapy - surgery, chemotherapy, radiotherapy, etc...
- Expression-Based Multi-Gene Signatures for CRC Recurrence and ChemoselectionChristopher Sears; Fiscal Year: 2012..response to therapies used to treat post-surgical CRC patients including major chemotherapies and external beam radiotherapy. The initial assay developed and evaluated in Phase II requires only 4 genes to predict recurrence (mCRC) with ..
- Translating CBT-Insomnia for Lung Cancer into practice: A RCTGrace E Dean; Fiscal Year: 2013..COPD), and the effects of lung cancer treatment, in particular, partial lung resection and postoperative radiotherapy can result in impaired pulmonary function resulting in hyperarousal from pain, cough and dyspnea leading to a ..
- Role of EGFR in DNA Repair and Radiation Response in Non Small Cell Lung CancerCHAITANYA SURESH NIRODI; Fiscal Year: 2012b>Radiotherapy, either alone, or in combination with chemotherapy, is frequently used in the treatment of patients with non-small cell lung carcinoma...
- Novel multivalent/multifunctional agents derived from a humanized anti-insulin-liThomas M Cardillo; Fiscal Year: 2010..It has resisted attempts of curative radiotherapy and chemotherapy...
- Jack Roth; Fiscal Year: 2016..Molecular Signatures for Individualizing Lung Cancer;2. Risk Prediction for Platinum-based Chemotherapy and Radiotherapy Outcome in Non-Small Cell Lung Cancer Patients;3. Targeting the Tumor Microenvironment in NSCLC;4...
- Treatment of Osteoradionecrosis with Bone Marrow Stromal CellsSunday O Akintoye; Fiscal Year: 2010..In the oro-facial region, osteoradionecrosis is a major complication of head and neck cancer radiotherapy characterized by tissue dehiscence, bone exposure, facial deformities, compromised oro-facial function and ..
- Mechanisms of radiosensitization by 2-methoxyestradiol in prostate cancer modelsJames M Larner; Fiscal Year: 2012..A promising candidate for enhancement of prostate tumor radiotherapy is the naturally occurring estrogen metabolite, 2-methoxyestradiol (2-ME)...
- JAMES MATTHEW BARNES; Fiscal Year: 2015..often have survival rates as low as one year, even after surgical resection of the tumor and combined chemo and radiotherapy. As an example of the unmet therapeutic need for this tumor type, the alkylating agent temozolomide is one of ..
- Khaled Hassan; Fiscal Year: 2015..At diagnosis, most patients already have advanced-stage disease and the use of chemotherapy and radiotherapy is rarely curative...
- Hua Su; Fiscal Year: 2016..The only options are resection, embolization and radiotherapy, all of which may pose significant risk...
- BRENDA MARIE SANDMAIER; Fiscal Year: 2016..The overall goal of this project is to overcome these limitations by delivering targeted anti-CD45 radiotherapy using an ?-emitter, astatine-211 (211At), to sites of disease in dogs with spontaneous lymphoma...
- A Novel Testicular Germ Cell Maturation Model for Fertility Preservation in Pre-pKirk C Lo; Fiscal Year: 2012..Treatment modalities such as chemotherapy and radiotherapy can have a profound and irreversible impact on fertility...
- HEAT AND RADIATION EFFECTS ON TUMOR MICROCIRCULATIONMark Wesley Dewhirst; Fiscal Year: 2013..for how hypoxia and reactive oxygen/nitrogen species (ROS/RNS) regulate blood vessel growth (angiogenesis) and radiotherapy responses, via HIF-1 (hypoxia-inducible factor-1) and VEGF (vascular endothelial growth factor)...
- A Modulator of Innate Immunity for Preventing Hospital-Acquired InfectionsJames D Thacker; Fiscal Year: 2010..g. neonates, the elderly, chemo- or radiotherapy patients, HIV/AIDS patients)...
- 8th Annual Conference on Head and Neck CancerEben L Rosenthal; Fiscal Year: 2012..molecular genetics, tumor cell biology, immunology, gene therapy, organ-sparing surgery, radiology and imaging, radiotherapy, chemotherapy, chemoprevention, reconstructive surgery, and quality of life issues...
- Targeted Radiotherapy with 90Y-BC8 Monclonal Antibody, Fludarabine and TBI FollowWilliam I Bensinger; Fiscal Year: 2012..Although 131I has been highly successful with regard to delivering targeted radiotherapy, concerns about safety and the transportability of this technology due to high gamma emissions of 131I and the ..
- Human Umami Taste: Genetics of Psychophysical TraitsPaul A S Breslin; Fiscal Year: 2012..Hence, people who lose their sense of taste, such as radiotherapy patients, suffer nutrionally...
- Invasion of glioblastoma multiforme (GBM) cells in organotypic brain slicesZEV ARI BINDER; Fiscal Year: 2013..The average survival with surgery, radiotherapy, and chemotherapy is 14.6 months and is often marked by tumor recurrence after treatment...
- Predictive Markers in Metastatic Renal CancerPhillip G Febbo; Fiscal Year: 2012..by applicant): Metastatic renal cell carcinoma (RCC) is a dismal disease, with nearly uniform resistance to radiotherapy, chemotherapy and immunotherapy...
- Paul Dent; Fiscal Year: 2014..In vivo we have noted in one GBM model that OSU-03012 can enhance animal survival and interact with radiotherapy to further prolong survival...
- Suppression of glioma invasion by a bicistronic constuctJASTI RAO; Fiscal Year: 2007..These gliomas are highly resistant even to combinations of different therapies such as surgery, radiotherapy, and chemotherapy...
- Molecular Epidemiology of Secondary Lung CancerPeter Shields; Fiscal Year: 2007Several studies indicate that women with breast cancer who undergo radiotherapy are susceptible to secondary lung cancer, whether they are smokers or nonsmokers...
- RADIOPHARMACEUTICALS FOR BREAST TUMOR IMAGING & THERAPYJohn Katzenellenbogen; Fiscal Year: 2006..of estrogens, which if labeled with suitable radionuclides, could be used for diagnostic imaging or radiotherapy or breast tumors...
- Nanotechnology enabled desktop image-guided microbeam radiation therapy systemOTTO Z contact ZHOU; Fiscal Year: 2010DESCRIPTION (Provided by the applicant): Today, state-of-the-art radiotherapy provides excellent benefits for patients with early stage and radiosensitive cancers...
- DOSIMETRY IN CHILDREN AND YOUNG ADULTS WITH NEUROBLASTOMA OR NEUROENDOCRINE TUMORM SUE O DORISIO; Fiscal Year: 2009Molecularly targeted radiotherapy using 131I-MIBG has been demonstrated to improve survival in neuroblastoma, but the dose is limited by bone marrow toxicity...
- A Phase II Study to Test the Correlation of a Radiation Pneumonitis Imaging BiomaThomas M Guerrero; Fiscal Year: 2010..RP is the dose limiting toxicity in thoracic radiotherapy for lung cancer making local control (based on bronchoscopic biopsy) achievable in less than 20% of patients...
- A Therapeutic Agent for Radiation-induced Lung FibrosisSHUAN HUANG; Fiscal Year: 2009..Lung fibrosis also develops as a consequence of multiple causes, including radiotherapy and chemotherapy for lung neoplasms...
- Effectiveness of Early Stage Prostate Cancer TreatmentMARTIN G contact SANDA; Fiscal Year: 2010..comparing the 3 most common contemporary treatments for early stage prostate cancer: prostatectomy, external radiotherapy, and brachytherapy. We propose to address this knowledge gap to facilitate treatment decisions...
- Gene Therapy for RetinoblastomaRichard Hurwitz; Fiscal Year: 2003..therapy for retinoblastoma utilizes surgical enucleation with resulting blindness and facial deformities or radiotherapy and chemotherapy that result in both local and systemic toxicity including an increase in the occurrence of ..
- SUPERHEATED DROP DETECTORS FOR DOSIMETRY IN RADIOTHERAPYRavinder Nath; Fiscal Year: 2001..neutron-sensitive and photon-insensitive probes for in- vivo measurements of the photoneutron contamination of radiotherapy x-ray beams have been developed...
- Development of a canine model of radiotherapy induced oral mucositisDorothy C Brown; Fiscal Year: 2010..Up to 90% of patients with head and neck cancer (HNC) receiving radiotherapy (RT) will develop OM...
- PROGNOSTIC BIOMARKERS FOR HEAD AND NECK CANCERK Ang; Fiscal Year: 2002..Since treatment consisted of radiotherapy only in all patients, the study population is ideal for addressing the value of EGFR expression in predicting ..
- Antioxidant Interactions with Prostate Cancer TreatmentsKathleen Shiverick; Fiscal Year: 2007..Recent improvements in external beam radiotherapy and interstitial brachytherapy (implantation of radioactive pellets) have made this minimally invasive ..
- NEOADJUVANT THERAPY OF OR CANCER BY INHIBITING NF-KAPPABCun Yu Wang; Fiscal Year: 2003..At advanced stage, p53 is mutated in about 60 percent of tumors and the effectiveness of chemotherapy and radiotherapy has been very disappointing...
- Image-guided Adaptive IMRT for Head and Neck CancerDavid Schwartz; Fiscal Year: 2009DESCRIPTION (provided by applicant): Current head and neck (H&N) intensity modulated radiotherapy (IMRT) techniques cause severe discomfort and functional morbidity...
- MECHANISMS OF CANNABINOID'S ANTIEMETIC ACTIONSNISSAR DARMANI; Fiscal Year: 2007..The immediate phase of vomiting induced by chemo- or radiotherapy can be treated with serotonin 5-HT3 receptor antagonists, however, there is currently no clinically available ..