radiotherapy

Summary

Summary: The use of IONIZING RADIATION to treat malignant NEOPLASMS and some benign conditions.

Top Publications

  1. ncbi CTCAE v3.0: development of a comprehensive grading system for the adverse effects of cancer treatment
    Andy Trotti
    H Lee Moffitt Cancer Center at the University of South Florida, Tampa, FL 33612, USA
    Semin Radiat Oncol 13:176-81. 2003
  2. pmc A review of update clinical results of carbon ion radiotherapy
    Hirohiko Tsujii
    Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba, Japan
    Jpn J Clin Oncol 42:670-85. 2012
  3. ncbi Postoperative irradiation with or without concomitant chemotherapy for locally advanced head and neck cancer
    Jacques Bernier
    Department of Radio Oncology, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland
    N Engl J Med 350:1945-52. 2004
  4. ncbi Preoperative versus postoperative chemoradiotherapy for rectal cancer
    Rolf Sauer
    Department of Radiation Therapy, University of Erlangen, Erlangen, Germany
    N Engl J Med 351:1731-40. 2004
  5. pmc Adjuvant whole-brain radiotherapy versus observation after radiosurgery or surgical resection of one to three cerebral metastases: results of the EORTC 22952-26001 study
    Martin Kocher
    University of Cologne, Cologne, Germany
    J Clin Oncol 29:134-41. 2011
  6. doi Risk-adapted targeted intraoperative radiotherapy versus whole-breast radiotherapy for breast cancer: 5-year results for local control and overall survival from the TARGIT-A randomised trial
    Jayant S Vaidya
    Clinical Trials Group, Division of Surgery and Interventional Science, University College London, London, UK Department of Surgery, Royal Free Hospital, London, UK Department of Surgery, Whittington Hopsital, London, UK Electronic address
    Lancet 383:603-13. 2014
  7. ncbi Concurrent chemotherapy and radiotherapy for organ preservation in advanced laryngeal cancer
    Arlene A Forastiere
    Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21231 1000, USA
    N Engl J Med 349:2091-8. 2003
  8. ncbi Palifermin for oral mucositis after intensive therapy for hematologic cancers
    Ricardo Spielberger
    City of Hope National Medical Center, Department of Hematology and Hematopoietic Cell Transplantation and Kaiser Permanente BMT Program, Duarte, Calif 91010, USA
    N Engl J Med 351:2590-8. 2004
  9. pmc Proportion of second cancers attributable to radiotherapy treatment in adults: a cohort study in the US SEER cancer registries
    Amy Berrington de Gonzalez
    Radiation Epidemiology Branch, National Cancer Institute, Bethesda, MD 20892, USA
    Lancet Oncol 12:353-60. 2011
  10. doi Memory function before and after whole brain radiotherapy in patients with and without brain metastases
    Grit Welzel
    Department of Radiation Oncology, University Medical Center Mannheim, University of Heidelberg, Mannheim, Germany
    Int J Radiat Oncol Biol Phys 72:1311-8. 2008

Research Grants

  1. Regulation of epithelial cell homeostasis by actin microfilaments
    Seema Khurana; Fiscal Year: 2010
  2. TIMOTHY L SITA; Fiscal Year: 2016
  3. Ted A Bateman; Fiscal Year: 2015
  4. Enhancing radiation and cisplatin HNSCC cell killing by inhibiting mitochondrial
    Lynn Harrison; Fiscal Year: 2013
  5. Contribution of c-Jun N-terminal kinase activity to vestibular schwannoma growth
    Marlan R Hansen; Fiscal Year: 2013
  6. RADIATION-INDUCED THYROID CANCER
    Heinz Ulrich G Weier; Fiscal Year: 2011
  7. PKC delta and cell renewal in irradiated taste epithelium
    MARY ELAINE REYLAND; Fiscal Year: 2012
  8. Mechanism of Irradiation Pulmonary Fibrosis
    Joel S Greenberger; Fiscal Year: 2012
  9. Inhibition of matrix proteases to sensitize medulloblastoma cells to radiation
    Andrei L Gartel; Fiscal Year: 2013
  10. Edward A Neuwelt; Fiscal Year: 2015

Detail Information

Publications379 found, 100 shown here

  1. ncbi CTCAE v3.0: development of a comprehensive grading system for the adverse effects of cancer treatment
    Andy Trotti
    H Lee Moffitt Cancer Center at the University of South Florida, Tampa, FL 33612, USA
    Semin Radiat Oncol 13:176-81. 2003
    ..This article updates recent progress in the evolution of adverse effects grading systems and reviews the development of CTCAE v3.0...
  2. pmc A review of update clinical results of carbon ion radiotherapy
    Hirohiko Tsujii
    Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba, Japan
    Jpn J Clin Oncol 42:670-85. 2012
    ..This is practically an ideal property from the standpoint of cancer radiotherapy. Clinical studies have been carried out in the world to confirm the efficacy of carbon ions against a variety ..
  3. ncbi Postoperative irradiation with or without concomitant chemotherapy for locally advanced head and neck cancer
    Jacques Bernier
    Department of Radio Oncology, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland
    N Engl J Med 350:1945-52. 2004
    We compared concomitant cisplatin and irradiation with radiotherapy alone as adjuvant treatment for stage III or IV head and neck cancer.
  4. ncbi Preoperative versus postoperative chemoradiotherapy for rectal cancer
    Rolf Sauer
    Department of Radiation Therapy, University of Erlangen, Erlangen, Germany
    N Engl J Med 351:1731-40. 2004
    ..In recent years, encouraging results with preoperative radiotherapy have been reported...
  5. pmc Adjuvant whole-brain radiotherapy versus observation after radiosurgery or surgical resection of one to three cerebral metastases: results of the EORTC 22952-26001 study
    Martin Kocher
    University of Cologne, Cologne, Germany
    J Clin Oncol 29:134-41. 2011
    This European Organisation for Research and Treatment of Cancer phase III trial assesses whether adjuvant whole-brain radiotherapy (WBRT) increases the duration of functional independence after surgery or radiosurgery of brain metastases.
  6. doi Risk-adapted targeted intraoperative radiotherapy versus whole-breast radiotherapy for breast cancer: 5-year results for local control and overall survival from the TARGIT-A randomised trial
    Jayant S Vaidya
    Clinical Trials Group, Division of Surgery and Interventional Science, University College London, London, UK Department of Surgery, Royal Free Hospital, London, UK Department of Surgery, Whittington Hopsital, London, UK Electronic address
    Lancet 383:603-13. 2014
    The TARGIT-A trial compared risk-adapted radiotherapy using single-dose targeted intraoperative radiotherapy (TARGIT) versus fractionated external beam radiotherapy (EBRT) for breast cancer...
  7. ncbi Concurrent chemotherapy and radiotherapy for organ preservation in advanced laryngeal cancer
    Arlene A Forastiere
    Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21231 1000, USA
    N Engl J Med 349:2091-8. 2003
    Induction chemotherapy with cisplatin plus fluorouracil followed by radiotherapy is the standard alternative to total laryngectomy for patients with locally advanced laryngeal cancer...
  8. ncbi Palifermin for oral mucositis after intensive therapy for hematologic cancers
    Ricardo Spielberger
    City of Hope National Medical Center, Department of Hematology and Hematopoietic Cell Transplantation and Kaiser Permanente BMT Program, Duarte, Calif 91010, USA
    N Engl J Med 351:2590-8. 2004
    Oral mucositis is a complication of intensive chemotherapy and radiotherapy with no effective treatment...
  9. pmc Proportion of second cancers attributable to radiotherapy treatment in adults: a cohort study in the US SEER cancer registries
    Amy Berrington de Gonzalez
    Radiation Epidemiology Branch, National Cancer Institute, Bethesda, MD 20892, USA
    Lancet Oncol 12:353-60. 2011
    ..made the long-term risks from treatments more important, including the risk of developing a second cancer after radiotherapy. We aimed to estimate the proportion of second cancers attributable to radiotherapy in adults with data from ..
  10. doi Memory function before and after whole brain radiotherapy in patients with and without brain metastases
    Grit Welzel
    Department of Radiation Oncology, University Medical Center Mannheim, University of Heidelberg, Mannheim, Germany
    Int J Radiat Oncol Biol Phys 72:1311-8. 2008
    To prospectively compare the effect of prophylactic and therapeutic whole brain radiotherapy (WBRT) on memory function in patients with and without brain metastases.
  11. doi Hypoxic modification of radiotherapy in squamous cell carcinoma of the head and neck--a systematic review and meta-analysis
    Jens Overgaard
    Department of Experimental Clinical Oncology, Aarhus University Hospital, Aarhus, Denmark
    Radiother Oncol 100:22-32. 2011
    The importance of tumour hypoxia for the outcome of radiotherapy has been under investigation for decades...
  12. ncbi Cisplatin and fluorouracil alone or with docetaxel in head and neck cancer
    Marshall R Posner
    Dana Farber Cancer Institute, Boston, MA 02115, USA
    N Engl J Med 357:1705-15. 2007
    ....
  13. ncbi Excessive toxicity when treating central tumors in a phase II study of stereotactic body radiation therapy for medically inoperable early-stage lung cancer
    Robert Timmerman
    Department of Radiation Oncology, The University of Texas Southwestern Medical Center, 5801 Forest Park Rd, Dallas, TX 75390 9183, USA
    J Clin Oncol 24:4833-9. 2006
    ..Building on a previously reported phase I trial, we carried out a prospective phase II trial using stereotactic body radiation therapy (SBRT) in this population...
  14. ncbi Long-term results of the M. D. Anderson randomized dose-escalation trial for prostate cancer
    Deborah A Kuban
    Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Int J Radiat Oncol Biol Phys 70:67-74. 2008
    To report the long-term results of a randomized radiotherapy dose escalation trial for prostate cancer.
  15. ncbi Preventing or reducing late side effects of radiation therapy: radiobiology meets molecular pathology
    Søren M Bentzen
    University of Wisconsin School of Medicine and Public Health, Department of Human Oncology, K4 316 Clinical Science Center, 600 Highland Avenue, Madison, Wisconsin 53792, USA
    Nat Rev Cancer 6:702-13. 2006
    ..Unfortunately, early and late toxicity limits the deliverable intensity of radiotherapy, and might affect the long-term health-related quality of life of the patient...
  16. pmc Metastasis after radical prostatectomy or external beam radiotherapy for patients with clinically localized prostate cancer: a comparison of clinical cohorts adjusted for case mix
    Michael J Zelefsky
    Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    J Clin Oncol 28:1508-13. 2010
    We assessed the effect of radical prostatectomy (RP) and external beam radiotherapy (EBRT) on distant metastases (DM) rates in patients with localized prostate cancer treated with RP or EBRT at a single specialized cancer center.
  17. ncbi The hazard of accelerated tumor clonogen repopulation during radiotherapy
    H R Withers
    Department of Radiation Oncology, Jonsson Comprehensive Cancer Center, UCLA
    Acta Oncol 27:131-46. 1988
    When analysis of results of radiotherapy for nearly 500 patients with oropharyngeal cancer showed evidence for rapid tumor regrowth during extensions of treatment from about 5 weeks to about 8 weeks, we searched the literature on ..
  18. ncbi Radiation injury and neurogenesis
    Michelle L Monje
    Department of Neurosurgery, MSLS P309, MC 5487, Stanford, CA, USA
    Curr Opin Neurol 16:129-34. 2003
    ..Children and adults who receive radiotherapy involving the brain frequently experience a progressive cognitive decline...
  19. doi Radiotherapy with or without chemotherapy in muscle-invasive bladder cancer
    Nicholas D James
    University of Birmingham, School of Cancer Sciences, Edgbaston, Birmingham B15 2TT, United Kingdom
    N Engl J Med 366:1477-88. 2012
    b>Radiotherapy is an alternative to cystectomy in patients with muscle-invasive bladder cancer...
  20. ncbi Dose-response in radiotherapy for localized prostate cancer: results of the Dutch multicenter randomized phase III trial comparing 68 Gy of radiotherapy with 78 Gy
    Stephanie T H Peeters
    Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands
    J Clin Oncol 24:1990-6. 2006
    To determine whether a dose of 78 Gy improves outcome compared with a conventional dose of 68 Gy for prostate cancer patients treated with three-dimensional conformal radiotherapy.
  21. ncbi Effects of an integrated yoga program in modulating psychological stress and radiation-induced genotoxic stress in breast cancer patients undergoing radiotherapy
    Birendranath Banerjee
    Genome Stability Laboratory, Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    Integr Cancer Ther 6:242-50. 2007
    ..well as depression levels and radiation-induced DNA damage were studied in 68 breast cancer patients undergoing radiotherapy. Two psychological questionnaires--Hospital Anxiety and Depression Scale (HADS) and Perceived Stress Scale (PSS)..
  22. ncbi INT 0123 (Radiation Therapy Oncology Group 94-05) phase III trial of combined-modality therapy for esophageal cancer: high-dose versus standard-dose radiation therapy
    Bruce D Minsky
    Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Clin Oncol 20:1167-74. 2002
    ..To compare the local/regional control, survival, and toxicity of combined-modality therapy using high-dose (64.8 Gy) versus standard-dose (50.4 Gy) radiation therapy for the treatment of patients with esophageal cancer...
  23. doi Radiotherapy and short-term androgen deprivation for localized prostate cancer
    Christopher U Jones
    Radiological Associates of Sacramento, Sacramento, CA 95816, USA
    N Engl J Med 365:107-18. 2011
    It is not known whether short-term androgen-deprivation therapy (ADT) before and during radiotherapy improves cancer control and overall survival among patients with early, localized prostate adenocarcinoma.
  24. ncbi Obesity in adult survivors of childhood acute lymphoblastic leukemia: a report from the Childhood Cancer Survivor Study
    Kevin C Oeffinger
    Department of Family Practice and Community Medicine, University of Texas Southwestern Medical Center at Dallas, 753900 9067, USA
    J Clin Oncol 21:1359-65. 2003
    ..To determine whether adult survivors (>or= 18 years of age) of childhood acute lymphoblastic leukemia (ALL) are at increased risk for obesity and to assess patient and treatment variables that influence risk...
  25. ncbi Guidelines for the assessment of oral mucositis in adult chemotherapy, radiotherapy and haematopoietic stem cell transplant patients
    Barry Quinn
    Royal Marsden School of Cancer Nursing and Rehabilitation, London, UK
    Eur J Cancer 44:61-72. 2008
    Oral mucositis (OM) is a serious consequence of some chemotherapy and radiotherapy regimens. A number of reliable instruments are available to assess OM, but none are universally accepted...
  26. ncbi Three-dimensional intrafractional movement of prostate measured during real-time tumor-tracking radiotherapy in supine and prone treatment positions
    Kei Kitamura
    Department of Radiology, Hokkaido University School of Medicine, Sapporo, Japan
    Int J Radiat Oncol Biol Phys 53:1117-23. 2002
    ..To quantify three-dimensional (3D) movement of the prostate gland with the patient in the supine and prone positions and to analyze the movement frequency for each treatment position...
  27. ncbi Dose-response relationship in local radiotherapy for hepatocellular carcinoma
    Hee Chul Park
    Department of Radiation Oncology, Brain Korea 21 Project for Medical Science, Seoul, South Korea
    Int J Radiat Oncol Biol Phys 54:150-5. 2002
    Dose escalation using three-dimensional conformal radiotherapy (3D-CRT) is based on the hypothesis that increasing the dose can enhance tumor control...
  28. pmc Targeting the TGF-beta1 pathway to prevent normal tissue injury after cancer therapy
    Mitchell S Anscher
    Department of Radiation Oncology, Virginia Commonwealth University, Richmond, Virginia, USA
    Oncologist 15:350-9. 2010
    ....
  29. doi Quantification of the relative biological effectiveness for ion beam radiotherapy: direct experimental comparison of proton and carbon ion beams and a novel approach for treatment planning
    Thilo Elsasser
    Department of Biophysics, GSI Helmholtz Centre for Heavy Ion Research, Darmstadt, Germany
    Int J Radiat Oncol Biol Phys 78:1177-83. 2010
    ....
  30. doi Incidence of heart disease in 35,000 women treated with radiotherapy for breast cancer in Denmark and Sweden
    Paul McGale
    Clinical Trial Service Unit, University of Oxford, UK
    Radiother Oncol 100:167-75. 2011
    ..To study incidence of radiation-related heart disease in a large population of breast cancer patients followed for up to 30 years...
  31. doi Preoperative short-course radiotherapy with delayed surgery in primary rectal cancer
    D Pettersson
    Department of Molecular Medicine and Surgery, Uppsala, Sweden
    Br J Surg 99:577-83. 2012
    Short-course radiotherapy (SRT) with immediate surgery and long-course chemoradiotherapy (CRT) are currently the standard preoperative treatment options for rectal cancer...
  32. pmc A modified Inflammatory Bowel Disease questionnaire and the Vaizey Incontinence questionnaire are simple ways to identify patients with significant gastrointestinal symptoms after pelvic radiotherapy
    F A Olopade
    Department of Medicine and Therapeutics, Imperial College Faculty of Medicine, Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, UK
    Br J Cancer 92:1663-70. 2005
    After radiotherapy for pelvic cancer, chronic gastrointestinal problems may affect quality of life (QOL) in 6-78% of patients...
  33. doi AVAglio: Phase 3 trial of bevacizumab plus temozolomide and radiotherapy in newly diagnosed glioblastoma multiforme
    O L Chinot
    Service de Neuro Oncologie, Centre Hospitalo Universitaire Timone, Universite de la Mediterranee, Marseilles, France
    Adv Ther 28:334-40. 2011
    ..We describe the protocol for the AVAglio phase 3 registration trial, which is designed to evaluate the efficacy and safety of combining bevacizumab with standard-of-care therapy in patients with newly diagnosed GBM...
  34. ncbi Feasibility report of image guided stereotactic body radiotherapy (IG-SBRT) with tomotherapy for early stage medically inoperable lung cancer using extreme hypofractionation
    Wes Hodge
    Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA
    Acta Oncol 45:890-6. 2006
    ..dosimetric aspects, and daily image-guidance capability with megavoltage CT (MVCT) of stereotactic body radiotherapy (SBRT) using helical tomotherapy for medically inoperable T1/2 N0 M0 non-small cell lung cancer...
  35. ncbi Twice-daily compared with once-daily thoracic radiotherapy in limited small-cell lung cancer treated concurrently with cisplatin and etoposide
    A T Turrisi
    Medical University of South Carolina, Charleston 29425, USA
    N Engl J Med 340:265-71. 1999
    For small-cell lung cancer confined to one hemithorax (limited small-cell lung cancer), thoracic radiotherapy improves survival, but the best ways of integrating chemotherapy and thoracic radiotherapy remain unsettled...
  36. ncbi Radiotherapy-related fatigue
    Barbara Alicja Jereczek-Fossa
    Department of Radiotherapy, European Institute of Oncology, Via Ripamonti 435, 20141, Milan, Italy
    Crit Rev Oncol Hematol 41:317-25. 2002
    b>Radiotherapy-induced fatigue is a common early and chronic side-effect of irradiation, reported in up to 80 and 30% of patients during radiation therapy and at follow-up visits, respectively...
  37. ncbi Local radiotherapy for patients with unresectable hepatocellular carcinoma
    Won Park
    Department of Radiation Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea
    Int J Radiat Oncol Biol Phys 61:1143-50. 2005
    To evaluate the response to local radiotherapy (RT) for unresectable hepatocellular carcinoma (HCC) and to analyze the dose-response relationship and the treatment-related morbidities.
  38. ncbi Impact of short-term preoperative radiotherapy on health-related quality of life and sexual functioning in primary rectal cancer: report of a multicenter randomized trial
    Corrie A M Marijnen
    Department of Clinical Oncology, Leiden University Medical Center, K1 P, PO Box 9600, 2300 RC Leiden, The Netherlands
    J Clin Oncol 23:1847-58. 2005
    Few prospective studies have been performed about the impact of preoperative radiotherapy (PRT) or total mesorectal excision (TME) on health-related quality of life (HRQL) and sexual functioning in patients with resectable rectal cancer...
  39. pmc Radiotherapy dose-volume effects on salivary gland function
    Joseph O Deasy
    Department of Radiation Oncology, Washington University School of Medicine, St Louis, MO 63110, USA
    Int J Radiat Oncol Biol Phys 76:S58-63. 2010
    Publications relating parotid dose-volume characteristics to radiotherapy-induced salivary toxicity were reviewed. Late salivary dysfunction has been correlated to the mean parotid gland dose, with recovery occurring with time...
  40. ncbi Involved-field radiotherapy is equally effective and less toxic compared with extended-field radiotherapy after four cycles of chemotherapy in patients with early-stage unfavorable Hodgkin's lymphoma: results of the HD8 trial of the German Hodgkin's Lymph
    Andreas Engert
    Department I of Internal Medicine, University Hospital Cologne, Cologne 50924, Germany
    J Clin Oncol 21:3601-8. 2003
    To investigate whether radiotherapy can be reduced without loss of efficacy from extended field (EF) to involved field (IF) after four cycles of chemotherapy.
  41. pmc Extent of MGMT promoter methylation correlates with outcome in glioblastomas given temozolomide and radiotherapy
    J Dunn
    Department of Surgery and Oncology, School of Cancer Studies, University of Liverpool, Liverpool, UK
    Br J Cancer 101:124-31. 2009
    ..In this study, we investigated MGMT promoter methylation in glioblastomas treated with temozolomide and radiotherapy in a single UK treatment centre.
  42. ncbi Treatment outcomes and late complications of 849 patients with nasopharyngeal carcinoma treated with radiotherapy alone
    Shyh An Yeh
    Department of Radiation Oncology, Kaohsiung Chang Gung Memorial Hospital, Taiwan
    Int J Radiat Oncol Biol Phys 62:672-9. 2005
    The objective of this study was to describe the treatment outcomes and treatment-related complications of nasopharyngeal carcinoma (NPC) patients treated with radiotherapy alone.
  43. pmc Normal tissue reactions to radiotherapy: towards tailoring treatment dose by genotype
    Gillian C Barnett
    Department of Oncology, University of Cambridge, Oncology Centre, Addenbrooke s Hospital, Hills Road, Cambridge CB2 0QQ, UK
    Nat Rev Cancer 9:134-42. 2009
    A key challenge in radiotherapy is to maximize radiation doses to cancer cells while minimizing damage to surrounding healthy tissue...
  44. doi Phase I/II study of oncolytic HSV GM-CSF in combination with radiotherapy and cisplatin in untreated stage III/IV squamous cell cancer of the head and neck
    Kevin J Harrington
    Institute of Cancer Research, 237 Fulham Road, London, United Kingdom
    Clin Cancer Res 16:4005-15. 2010
    ....
  45. ncbi Task Group 142 report: quality assurance of medical accelerators
    Eric E Klein
    Washington University, St Louis, Missouri, USA
    Med Phys 36:4197-212. 2009
    ..For example, machines that are used for radiosurgery treatments or intensity-modulated radiotherapy (IMRT) require different tests and/or tolerances...
  46. ncbi Consensus guidelines for the management of radiation dermatitis and coexisting acne-like rash in patients receiving radiotherapy plus EGFR inhibitors for the treatment of squamous cell carcinoma of the head and neck
    J Bernier
    Department of Radiation Oncology, Genolier Swiss Medical Network, Genolier, Geneva, Switzerland
    Ann Oncol 19:142-9. 2008
    Radiation dermatitis occurs to some degree in most patients receiving radiotherapy, with or without chemotherapy...
  47. doi Cognitive and radiological effects of radiotherapy in patients with low-grade glioma: long-term follow-up
    Linda Douw
    Department of Neurology, VU University Medical Center, Amsterdam, Netherlands
    Lancet Neurol 8:810-8. 2009
    ..with low-grade glioma (LGG) a mean of 6 years after diagnosis suggested that the tumour itself, rather than the radiotherapy used to treat it, has the most deleterious effect on cognitive functioning; only high fraction dose ..
  48. ncbi Evaluation of 3'-deoxy-3'-18F-fluorothymidine for monitoring tumor response to radiotherapy and photodynamic therapy in mice
    Masahiro Sugiyama
    Department of Radiology, Hamamatsu University School of Medicine, Hamamatsu, Japan
    J Nucl Med 45:1754-8. 2004
    3'-Deoxy-3'-18F-fluorothymidine (18F-FLT) has been suggested as a new PET tracer for imaging tumor proliferation. We investigated the use of 18F-FLT to monitor the response of tumors to radiotherapy and photodynamic therapy (PDT) in mice.
  49. ncbi A phase I study of topical Tempol for the prevention of alopecia induced by whole brain radiotherapy
    James M Metz
    Department of Radiation Oncology, University of Pennsylvania, Philadelphia 19104 4283, USA
    Clin Cancer Res 10:6411-7. 2004
    ..This phase Ib study was designed to evaluate the safety and side effect profile of topical Tempol in patients with brain metastases being treated with whole brain radiotherapy.
  50. pmc Objective assessment of deformable image registration in radiotherapy: a multi-institution study
    Rojano Kashani
    Department of Radiation Oncology, University of Michigan, Ann Arbor Michigan 48109 0010, USA
    Med Phys 35:5944-53. 2008
    The looming potential of deformable alignment tools to play an integral role in adaptive radiotherapy suggests a need for objective assessment of these complex algorithms...
  51. pmc Mast cells are an essential component of human radiation proctitis and contribute to experimental colorectal damage in mice
    Karl Blirando
    Laboratory of Radiopathology and Experimental Therapeutics, Institute for Radiological Protection and Nuclear Safety IRSN, Fontenay aux Roses, France
    Am J Pathol 178:640-51. 2011
    ..Rectal tissue from patients treated with radiotherapy shows mast cell hyperplasia and activation, suggesting that these cells play a role in the development of ..
  52. pmc Genetic variants of the nonhomologous end joining gene LIG4 and severe radiation pneumonitis in nonsmall cell lung cancer patients treated with definitive radiotherapy
    Ming Yin
    Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
    Cancer 118:528-35. 2012
    ..The authors hypothesized that single nucleotide polymorphisms (SNPs) in NHEJ repair genes may affect clinical outcomes in patients with nonsmall cell lung cancer (NSCLC) who receive definitive radio(chemo)therapy...
  53. pmc CSF1R signaling blockade stanches tumor-infiltrating myeloid cells and improves the efficacy of radiotherapy in prostate cancer
    Jingying Xu
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90095 1735, USA
    Cancer Res 73:2782-94. 2013
    b>Radiotherapy is used to treat many types of cancer, but many treated patients relapse with local tumor recurrence...
  54. ncbi Comparison of radiotherapy alone with radiotherapy plus hyperthermia in locally advanced pelvic tumours: a prospective, randomised, multicentre trial. Dutch Deep Hyperthermia Group
    J Van der Zee
    Subdivision of Hyperthermia, Academic Medical Centre, Amsterdam, The Netherlands
    Lancet 355:1119-25. 2000
    Local-control rates after radiotherapy for locally advanced tumours of the bladder, cervix, and rectum are disappointing. We investigated the effect of adding hyperthermia to standard radiotherapy.
  55. ncbi Effects of radiation on normal tissue: consequences and mechanisms
    Helen B Stone
    Radiation Research Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, NIH, MD 20892 7440, USA
    Lancet Oncol 4:529-36. 2003
    ..Treatments that reduce the risk or severity of damage to normal tissue or that facilitate the healing of radiation injury are being developed. These could greatly improve the quality of life of patients treated for cancer...
  56. ncbi Palliation of metastatic bone pain: single fraction versus multifraction radiotherapy--a systematic review of randomised trials
    W M Sze
    Departament of Clinical Oncology, Pamela Youde Nethersole Eastern Hospital, Chai Wan, Hong Kong, PR China
    Clin Oncol (R Coll Radiol) 15:345-52. 2003
    Recent randomised studies have reported that single fraction radiotherapy is as effective as multifraction radiotherapy in relieving pain caused by bone metastasis...
  57. ncbi Dietary counseling improves patient outcomes: a prospective, randomized, controlled trial in colorectal cancer patients undergoing radiotherapy
    Paula Ravasco
    Unidade de Nutrição e Metabolismo, Instituto de Medicina Molecular, Faculdade de Medicina de Lisboa, Avenida Prof Egas Moniz, 1649 028 Lisboa, Portugal
    J Clin Oncol 23:1431-8. 2005
    To investigate the impact of dietary counseling or nutritional supplements on outcomes in cancer patients: nutritional, morbidity, and quality of life (QoL) during and 3 months after radiotherapy.
  58. ncbi Cancer incidence after localized therapy for prostate cancer
    Kihyuck Moon
    Department of Urology, University of Virginia, Charlottesville, Virginia 22908, USA
    Cancer 107:991-8. 2006
    ..In this study, the authors examined the size and significance of the observed association between occurrences of secondary cancers 5 years after radiotherapy in a large population of men with incident prostate cancer.
  59. ncbi Cisplatin, fluorouracil, and docetaxel in unresectable head and neck cancer
    Jan B Vermorken
    Department of Medical Oncology, Universitair Ziekenhuis Antwerpen, Edegem, Belgium
    N Engl J Med 357:1695-704. 2007
    ..We compared TPF with PF as induction chemotherapy in patients with locoregionally advanced, unresectable disease...
  60. doi Comparison of 12 deformable registration strategies in adaptive radiation therapy for the treatment of head and neck tumors
    Pierre Castadot
    Department of Radiation Oncology, Universite Catholique de Louvain, St Luc University Hospital, Brussels, Belgium
    Radiother Oncol 89:1-12. 2008
    ..shrinkage, and tissue edema induce substantial modification of patient's anatomy during head and neck (HN) radiotherapy (RT) or chemo-radiotherapy...
  61. ncbi Evaluation of nonrigid registration models for interfraction dose accumulation in radiotherapy
    Guillaume Janssens
    Communications and Remote Sensing Laboratory TELE, Universite Catholique de Louvain, 1348 Louvain la Neuve, Belgium
    Med Phys 36:4268-76. 2009
    ..For this purpose, the accuracy of nonrigid registration methods is assessed for dose accumulation based on the calculated deformations fields...
  62. pmc Prolonged expression of the γ-H2AX DNA repair biomarker correlates with excess acute and chronic toxicity from radiotherapy treatment
    Emma C Bourton
    Brunel Institute of Cancer Genetics and Pharmacogenomics, Brunel University, Uxbridge, Middlesex, UK
    Int J Cancer 129:2928-34. 2011
    The normal tissue tolerance levels to fractionated radiotherapy have been appreciated by a century of careful clinical observations and radiobiological studies in animals...
  63. pmc Early prediction of response to radiotherapy and androgen-deprivation therapy in prostate cancer by repeated functional MRI: a preclinical study
    Kathrine Røe
    Department of Radiation Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, PO Box 4953 Nydalen, 0424 Oslo, Norway
    Radiat Oncol 6:65. 2011
    ..We hypothesized that the combination of several functional parameters increased the predictive power...
  64. pmc Radiation induced CNS toxicity--molecular and cellular mechanisms
    C Belka
    Department of Radiation Oncology, , Hoppe Seyler Str 3,
    Br J Cancer 85:1233-9. 2001
    b>Radiotherapy of tumours proximal to normal CNS structures is limited by the sensitivity of the normal tissue...
  65. ncbi Late cognitive and radiographic changes related to radiotherapy: initial prospective findings
    C L Armstrong
    Departments of Neurology, University of Pennsylvania Medical School, Children s Hospital of Philadelphia, PA 19104, USA
    Neurology 59:40-8. 2002
    Assumptions about the damaging effects of radiotherapy (XRT) are based on studies in which total dose, dose fraction, treatment volume, degree of malignancy, chemotherapy, tumor recurrence, and neurologic comorbidity interact with XRT ..
  66. ncbi Cancer risks from medical radiation
    Elaine Ron
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, EPS 7048, 6120 Executive Boulevard, Bethesda, MD 20892, USA
    Health Phys 85:47-59. 2003
    ..Since then, continual improvements in diagnostic imaging and radiotherapy as well as the aging of our population have led to greater use of medical radiation...
  67. pmc The use of MRI in planning radiotherapy for gynaecological tumours
    I Barillot
    Clinique d Oncologie et Radiothérapie, Centre Régional Universitaire de Cancérologie Henry S Kaplan, Hopital Bretonneau, Tours, France
    Cancer Imaging 6:100-6. 2006
    ..in radiation treatment of gynaecological malignancies are mainly related to the tumour characteristics and the radiotherapy technique used...
  68. doi Increased risk of colon cancer after external radiation therapy for prostate cancer
    Elisabetta Rapiti
    Geneva Cancer Registry, Institute for Social and Preventive Medicine, University of Geneva, Geneva, Switzerland
    Int J Cancer 123:1141-5. 2008
    b>Radiotherapy can induce second cancers. Controversies still exist regarding the risk of second malignancies after irradiation for prostate cancer...
  69. doi Effectiveness of treatments for metastatic uveal melanoma
    James J Augsburger
    Department of Ophthalmology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA
    Am J Ophthalmol 148:119-27. 2009
    ..To evaluate and comment on published peer-reviewed literature for evidence of effectiveness of treatments for metastatic uveal melanoma...
  70. doi Acute toxicity of curative radiotherapy for intermediate- and high-risk localised prostate cancer in the EORTC trial 22991
    O Matzinger
    EORTC Headquarters, Belgium
    Eur J Cancer 45:2825-34. 2009
    This trial randomly assessed short-term adjuvant hormonal therapy added to radiotherapy (RT) for intermediate- and high-risk (UICC 1997 cT2a or cT1b-c with high PSA or Gleason score) localised prostate cancer...
  71. doi External beam radiotherapy for prostate cancer: urinary outcomes for men with high International Prostate Symptom Scores (IPSS)
    Renuka Malik
    Department of Radiation and Cellular Oncology, University of Chicago, Chicago, IL 60637, USA
    Int J Radiat Oncol Biol Phys 80:1080-6. 2011
    To report the urinary outcome of men treated for prostate cancer with external beam radiotherapy (EBRT) who have pretreatment obstructive urinary symptoms (International Prostate Symptom Score [IPSS] ≥ 15).
  72. doi Late radiation-induced heart disease after radiotherapy. Clinical importance, radiobiological mechanisms and strategies of prevention
    Nicolaus Andratschke
    Klinik und Poliklinik für Strahlentherapie und Radiologische Onkologie, Technische Universitat Munchen, Munich, Germany
    Radiother Oncol 100:160-6. 2011
    The clinical importance of radiation-induced heart disease, in particular in post-operative radiotherapy of breast cancer patients, has been recognised only recently...
  73. doi Image-guided radiotherapy: has it influenced patient outcomes?
    Alexis Bujold
    Département de Radio oncologie clinique enseignement recherche, Hopital Maisonneuve Rosemont, Universite de Montreal, Montreal, Canada
    Semin Radiat Oncol 22:50-61. 2012
    Cancer control and toxicity outcomes are the mainstay of evidence-based medicine in radiation oncology. However, radiotherapy is an intricate therapy involving numerous processes that need to be executed appropriately in order for the ..
  74. doi Radiotherapy in elderly patients with inoperable esophageal cancer. Is there a benefit?
    R Semrau
    Department of Radiation Oncology, University of Cologne, Kerpener Str 62, 50924, Cologne, Germany
    Strahlenther Onkol 188:226-32. 2012
    ..was to assess the prognosis of inoperable esophageal cancer patients ≥ 70 years undergoing definitive radiotherapy or radiochemotherapy...
  75. ncbi Association between polymorphisms in the DNA repair genes, XRCC1, APE1, and XPD and acute side effects of radiotherapy in breast cancer patients
    Jenny Chang-Claude
    Division of Clinical Epidemiology and Toxicology, German Cancer Research Center, Heidelberg, Germany
    Clin Cancer Res 11:4802-9. 2005
    ..We evaluated the association of six polymorphisms in the DNA repair genes: XRCC1 (Arg194Trp, Arg280His, and Arg399Gln), APE1 (Asp148Glu), and XPD (Lys751Gln and Asp312Asn), with the risk of acute skin reactions following radiotherapy.
  76. doi An economic evaluation of cetuximab combined with radiotherapy for patients with locally advanced head and neck cancer in Belgium, France, Italy, Switzerland, and the United Kingdom
    Ben Brown
    IMS Health, London, UK
    Value Health 11:791-9. 2008
    A phase III randomized trial that compared the combination of cetuximab and radiotherapy to radiotherapy alone in patients with locally advanced squamous cell carcinoma of the head and neck provided a platform for a comprehensive economic ..
  77. doi Dose to normal tissues outside the radiation therapy patient's treated volume: a review of different radiation therapy techniques
    James A Purdy
    Department of Radiation Oncology, University of California, Davis Medical Center, Sacramento, CA 95816, USA
    Health Phys 95:666-76. 2008
    ..Dose distributions for the various CRT techniques and the current status of available data for normal tissues, and whole body dose are reviewed...
  78. doi Acute and long-term gastrointestinal consequences of chemotherapy
    Frederic Di Fiore
    Digestive Oncology Unit, University Hospital Gasthuisberg, Herestraat 49, 3000 Leuven, Belgium
    Best Pract Res Clin Gastroenterol 23:113-24. 2009
    ..We herein review and discuss the main acute and late gastrointestinal toxicities of chemotherapy and/or radiotherapy for patients with gastrointestinal malignancies.
  79. ncbi Dosimetry for treatment with radiolabelled somatostatin analogues. A review
    M Cremonesi
    Medical Physics, European Institute of Oncology, Milan, Italy
    Q J Nucl Med Mol Imaging 54:37-51. 2010
    ..Special focus is given on recent improvements and indications for critical organ protection that light up challenging perspectives for PRRT...
  80. doi Predictors of weight loss during radiotherapy in patients with stage I or II head and neck cancer
    Alice Nourissat
    Clinical Epidemiology Unit, Laval University Cancer Research Center, Chuq Hotel Dieu de Quebec, Quebec City, Quebec, Canada
    Cancer 116:2275-83. 2010
    The purpose of the study was to identify predictors of weight loss during radiotherapy (RT) in patients with stage I or II head and neck (HN) cancer.
  81. doi Ocular ischemic syndrome secondary to carotid artery occlusion as a late complication of radiotherapy of nasopharyngeal carcinoma
    Yamei Tang
    Department of Neurology, The Second Affiliated Hospital, Sun Yat Sen University, Guangzhou, Guangdong Province, China
    J Neuroophthalmol 30:315-20. 2010
    ..Radiation therapy of the head and neck has a relatively high likelihood of causing vascular stenosis. However, we believe this to be the first reported case of OIS following radiotherapy for nasopharyngeal carcinoma.
  82. doi Toxicity at three years with and without irradiation of the internal mammary and medial supraclavicular lymph node chain in stage I to III breast cancer (EORTC trial 22922/10925)
    Oscar Matzinger
    European Organisation for Research and Treatment of Cancer EORTC, Headquarters, Brussels, Belgium
    Acta Oncol 49:24-34. 2010
    ..We present the toxicity reported until year 3 after treatment...
  83. doi A method to separate the rectum from the prostate during proton beam radiotherapy of prostate cancer patients
    Ulf Isacsson
    Sections of Oncology and Medical Radiation Physics, Department of Oncology, Radiology and Clinical Immunology, Uppsala University Hospital, Uppsala, Sweden
    Acta Oncol 49:500-5. 2010
    ..of prostate cancer is increasing, either as a single treatment modality or in combination with conventional radiotherapy. The proximity between prostate (target) and rectum (organ at risk) often leads to a compromise between dose to ..
  84. doi A review of the clinical evidence for intensity-modulated radiotherapy
    J Staffurth
    Cardiff University, Velindre Hospital, Whitchurch, Cardiff, UK
    Clin Oncol (R Coll Radiol) 22:643-57. 2010
    Intensity-modulated radiotherapy (IMRT) is a development of three-dimensional conformal radiotherapy that offers improvements in dosimetry in many clinical scenarios...
  85. pmc Treatment of patients with atypical meningiomas Simpson grade 4 and 5 with a carbon ion boost in combination with postoperative photon radiotherapy: the MARCIE trial
    Stephanie E Combs
    Department of Radiation Oncology, University Hospital of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    BMC Cancer 10:615. 2010
    ..A series or smaller studies has shown that postoperative radiotherapy in this patient population can increase progression-free survival, which translates into increased overall ..
  86. doi Skull base chordomas: efficacy of surgery followed by carbon ion radiotherapy
    Satoshi Takahashi
    Department of Neurosurgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Acta Neurochir (Wien) 151:759-69. 2009
    ..We report the effectiveness of combined radical skull base surgery with carbon ion radiotherapy for treating skull base chordomas.
  87. doi Effects of pulsed, spatially fractionated, microscopic synchrotron X-ray beams on normal and tumoral brain tissue
    E Brauer-Krisch
    European Synchrotron Radiation Facility, B P 220, 38043 Grenoble, France
    Mutat Res 704:160-6. 2010
    ..in the target volume in fractions of seconds, with a sharper penumbra than that produced in conventional radiotherapy. MRT research over the past 20 years has yielded many results from preclinical trials based on different animal ..
  88. pmc Chromosomal radiosensitivity and acute radiation side effects after radiotherapy in tumour patients--a follow-up study
    Reinhard Huber
    Department of Radiation Cytogenetics, HelmholtzZentrum Muenchen German Research Center for Environmental Health, Neuherberg, Germany
    Radiat Oncol 6:32. 2011
    ..are highly interested in optimizing doses especially for patients who tend to suffer from side effects of radiotherapy (RT). It seems to be helpful to identify radiosensitive individuals before RT...
  89. pmc Second malignant neoplasms and cardiovascular disease following radiotherapy
    Lois B Travis
    Rubin Center for Cancer Survivorship and Department of Radiation Oncology, James P Wilmot Cancer Center, University of Rochester Medical Center, 265 Crittenden Blvd, CU 420318, Rochester, NY 14642, USA
    J Natl Cancer Inst 104:357-70. 2012
    ..late adverse effects experienced by the growing number of cancer survivors worldwide and are due in part to radiotherapy. The National Council on Radiation Protection and Measurements (NCRP) convened an expert scientific committee ..
  90. doi Improvement, clinical course, and quality of life after palliative radiotherapy for recurrent glioblastoma
    Carsten Nieder
    Department of Internal Medicine Oncology and Radiation Oncology Units, Nordlandssykehuset HF, Bodø, Norway
    Am J Clin Oncol 31:300-5. 2008
    ..Serious late toxicity was uncommon, especially after conventional treatment and fractionated stereotactic radiotherapy (FSRT)...
  91. doi Prognostic significance of mid- and post-ABVD PET imaging in Hodgkin's lymphoma: the importance of involved-field radiotherapy
    D J Sher
    Department of Radiation Oncology, Dana Farber Cancer Institute and Brigham and Women s Hospital, Boston, MA, USA
    Ann Oncol 20:1848-53. 2009
    ..in Hodgkin's lymphoma (HL), it is unclear whether patients with 2-[fluorine-18]fluoro-2-deoxy-D-glucose (FDG)-PET positivity during and/or after CT can be rendered disease free with consolidative involved-field radiotherapy (IFRT).
  92. doi Dose-volume effects for normal tissues in external radiotherapy: pelvis
    Claudio Fiorino
    Medical Physics Department, San Raffaele Scientific Institute, Milan, Italy
    Radiother Oncol 93:153-67. 2009
    ..has become increasingly important, due to the rapidly increasing use of inverse-planned intensity-modulated radiotherapy (IMRT) and the consequent need of a quantitative assessment of dose-volume or biological-based cost functions...
  93. ncbi The radiotherapeutic injury--a complex 'wound'
    James W Denham
    Department of Radiation Oncology, Newcastle Mater Misericordiae Hospital, Newcastle University, Locked Bag 7, Hunter Region Mail Centre, NSW 2310, Newcastle, Australia
    Radiother Oncol 63:129-45. 2002
    ..therapy produces a series of repeated insults to tissues that undergo significant changes during the course of radiotherapy. Normal tissue responses are also influenced by rate of dose accumulation and other factors that relate to the ..
  94. ncbi The role of radiotherapy in cancer treatment: estimating optimal utilization from a review of evidence-based clinical guidelines
    Geoff Delaney
    Collaboration for Cancer Outcomes Research and Evaluation CCORE, Liverpool Hospital, Sydney, Australia
    Cancer 104:1129-37. 2005
    b>Radiotherapy utilization rates for cancer vary widely internationally. It has previously been suggested that approximately 50% of all cancer patients should receive radiation. However, this estimate was not evidence-based...
  95. ncbi Dosimetric verification in participating institutions in a stereotactic body radiotherapy trial for stage I non-small cell lung cancer: Japan clinical oncology group trial (JCOG0403)
    Teiji Nishio
    Radiation Oncology Division, National Cancer Center Hospital East, Kashiwa, Japan
    Phys Med Biol 51:5409-17. 2006
    A multicentre phase II trial of stereotactic body radiotherapy for T1N0M0 non-small cell lung cancer was initiated in Japan as the Japan Clinical Oncology Group trial (JCOG0403)...
  96. pmc Sensitivity of salivary glands to radiation: from animal models to therapies
    O Grundmann
    Department of Nutritional Sciences, University of Arizona, 1177 E 4th St, Shantz 421, PO Box 210038, Tucson, AZ 85721, USA
    J Dent Res 88:894-903. 2009
    ..Salivary glands are exquisitely sensitive to radiation and display acute and chronic responses to radiotherapy. This review will discuss clinical implications of radiosensitivity in normal salivary glands, compare animal ..
  97. pmc MGMT promoter methylation is predictive of response to radiotherapy and prognostic in the absence of adjuvant alkylating chemotherapy for glioblastoma
    Andreana L Rivera
    Departments of Pathology and Radiation Oncology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 0097, Houston, TX 77030, USA
    Neuro Oncol 12:116-21. 2010
    ..In patients who received radiotherapy alone following resection, methylation of the MGMT promoter correlated with an improved response to ..
  98. pmc The role of concurrent chemoradiotherapy in the treatment of locoregionally advanced nasopharyngeal carcinoma among endemic population: a meta-analysis of the phase III randomized trials
    Li Zhang
    Department of Medical Oncology, Sun Yat sen University Cancer Center, 651 Dongfeng Road East, Guangzhou, China
    BMC Cancer 10:558. 2010
    ....
  99. ncbi Health outcomes after prostatectomy or radiotherapy for prostate cancer: results from the Prostate Cancer Outcomes Study
    A L Potosky
    Applied Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, MD 20892 7344, USA
    J Natl Cancer Inst 92:1582-92. 2000
    Radical prostatectomy and external beam radiotherapy are the two major therapeutic options for treating clinically localized prostate cancer...
  100. pmc Radiotherapy and radiosurgery for benign skull base meningiomas
    Giuseppe Minniti
    Department of Radiotherapy Oncology, Sant Andrea Hospital, University La Sapienza, Rome, Italy
    Radiat Oncol 4:42. 2009
    ..New radiation techniques, including stereotactic radiosurgery (SRS), fractionated stereotactic radiotherapy (FSRT), and intensity-modulated radiotherapy (IMRT) have been developed as a more accurate technique of ..
  101. ncbi Randomised trial of standard 2D radiotherapy (RT) versus intensity modulated radiotherapy (IMRT) in patients prescribed breast radiotherapy
    Ellen Donovan
    Joint Department of Physics, Royal Marsden Hospital and Institute of Cancer Research, Sutton, Surrey, UK
    Radiother Oncol 82:254-64. 2007
    ..for partial volumes receiving >107% of the prescribed dose in a proportion of patients prescribed whole breast radiotherapy after tumour excision of early breast cancer...

Research Grants81

  1. Regulation of epithelial cell homeostasis by actin microfilaments
    Seema Khurana; Fiscal Year: 2010
    ..to both the pathogenesis of colorectal cancer as well as its resistance to chemotherapeutic drugs and radiotherapy. An understanding of apoptosis would help enhance normal physiology and ameliorate diseases...
  2. TIMOTHY L SITA; Fiscal Year: 2016
    ..The standard of care for newly diagnosed GBM is surgical resection followed by adjuvant radiotherapy and temozolomide (TMZ) chemotherapy...
  3. Ted A Bateman; Fiscal Year: 2015
    ..b>Radiotherapy for soft-tissue tumors in the pelvic region increases hip-fracture risk, resulting in substantial patient ..
  4. Enhancing radiation and cisplatin HNSCC cell killing by inhibiting mitochondrial
    Lynn Harrison; Fiscal Year: 2013
    ..Early stage disease is treated with surgery or radiotherapy alone, while advanced stage HNSCC is treated with a combination of cisplatin and radiotherapy...
  5. Contribution of c-Jun N-terminal kinase activity to vestibular schwannoma growth
    Marlan R Hansen; Fiscal Year: 2013
    ..Microsurgical removal and stereotactic radiosurgery/stereotactic radiotherapy (SRS/SRT) constitute the only current treatments for VSs and often result in deafness, tinnitus, facial ..
  6. RADIATION-INDUCED THYROID CANCER
    Heinz Ulrich G Weier; Fiscal Year: 2011
    ..who developed thyroid cancer without prior radiation exposure as well as tumors in adult patients who underwent radiotherapy as children or adults...
  7. PKC delta and cell renewal in irradiated taste epithelium
    MARY ELAINE REYLAND; Fiscal Year: 2012
    ..by applicant): Taste dysfunction, either loss or alteration in sensation, is a common occurrence during radiotherapy for head and neck cancer...
  8. Mechanism of Irradiation Pulmonary Fibrosis
    Joel S Greenberger; Fiscal Year: 2012
    ..Project Narrative This irradiation application addresses a critical problem in managing the side effects of thoracic radiotherapy for lung and esophagus cancer.
  9. Inhibition of matrix proteases to sensitize medulloblastoma cells to radiation
    Andrei L Gartel; Fiscal Year: 2013
    ..of uPAR and MMP-9 by RNAi technology could be a potential therapeutic approach to improve the efficacy of radiotherapy in medulloblastoma patients. Specific Aim 1...
  10. Edward A Neuwelt; Fiscal Year: 2015
    ..Current treatments for brain metastasis such as radiotherapy with or without chemotherapy have only short- term efficacy...
  11. QUYNH THU XUAN LE; Fiscal Year: 2016
    ..Despite dose escalation with conformal radiotherapy (RT), there is still a high intrathoracic failure rate...
  12. Autophagy in Brain Tumor
    Jin Ming Yang; Fiscal Year: 2013
    ..As eEF-2 kinase is overexpressed in malignant gliomas, targeting this kinase in combination with chemotherapy, radiotherapy, or other existing treatments to shuttle cells into more reliable and permanent pathways of cell death is an ..
  13. A Molecular targeting agent for systemic radiotherapy of metastatic Prostate Canc
    Kevin P Maresca; Fiscal Year: 2010
    ..This proposal is designed to generate the pre-clinical efficacy data for the corresponding therapeutic I-131-MIP-1072 in order to assess the possibilities of developing the imaging agent into an effective treatment for prostate cancer. ..
  14. CSHL Eukaryotic DNA Replication Conference
    David J Stewart; Fiscal Year: 2013
    ..crucial to cell division, uncontrolled growth is a hallmark of tumors, S phase is a major target for chemo- and radiotherapy and errors in DNA replication lead to genomic instability, the relevance of this meeting to cancer research, ..
  15. Tousled kinase contributes to survival of salivary acinar cells against radiation
    Gulshan Sunavala-Dossabhoy; Fiscal Year: 2013
    ..Oral complications predominantly affect patients undergoing radiotherapy for head and neck cancers, early stage lymphomas, and full-body radiation before bone marrow transplantation...
  16. Gutless Adenovirus Mediated Gene Therapy for Glioma
    Maria G Castro; Fiscal Year: 2011
    ..Mean survival time from the time of diagnosis is 6-12 months, in spite of advances in chemotherapy, surgery and radiotherapy. Harnessing the host's immune system to develop novel treatments for GBM has been attempted...
  17. Slow cycling brain tumor cancer stem cells
    BRENT REYNOLDS; Fiscal Year: 2010
    ..time of less than 1 year despite aggressive therapy that combines state-of- the-art imaging with surgery, radiotherapy and chemotherapy...
  18. Heat Shock-Induced Apoptosis
    Shawn B Bratton; Fiscal Year: 2012
    ..shock, or hyperthermia, is currently being used in clinical trials, either alone or as an adjunct to chemo- or radiotherapy for the treatment of various cancers. Unfortunately, very little is known about how heat shock kills cells...
  19. Darell D Bigner; Fiscal Year: 2016
    ..Project 1, led by Michael Zaiutsky, is entitled "Targeted Radiotherapy of Neoplastic Meningitis using Monoclonal Antibodies Labeled with Alpha Particle Emitting At...
  20. ASCORBATE-INDUCED RADIOSENSITIZATION IN PANCREATIC CANCER
    Joseph J Cullen; Fiscal Year: 2013
    ..extends this preclinical work to determine if this strategy can be used effectively as an adjuvant in radiotherapy for pancreatic cancer...
  21. Using Ketogenic Diets to Enhance Radio-Chemo-Therapy Response: A Phase I Trial
    DOUGLAS ROBERT SPITZ; Fiscal Year: 2012
    ..This is based on preliminary data in mice with human NSCLC or pancreas cancer xenografts fed KD during radiotherapy demonstrate enhanced therapeutic responses and increases in parameters indicative of oxidative stress with no ..
  22. JOHN P O'BRYAN; Fiscal Year: 2014
    ..b>Radiotherapy remains a major component of treatment modalities for controlling both malignant and benign glioblastomas...
  23. Martin G Pomper; Fiscal Year: 2014
    ..tumor cells harboring the EBV genome will already possess the TK that we can harness for targeted, enzymatic radiotherapy. Because the substrate specificity for the viral TK is orthogonal to that of cellular TK, we can use a ..
  24. Genetic Instability &Risk for Esophageal Carcinoma
    Xifeng Wu; Fiscal Year: 2012
    ..We will accrue 600 patients with EAC from M.D. Anderson Cancer Center who have not received chemotherapy or radiotherapy and are residents of Texas...
  25. Martin G Pomper; Fiscal Year: 2016
    ..mAb) [111In]capromab pendetide (Cyt-356, ProstaScint) is being used to identify candidates for salvage radiotherapy. However, intact antibodies tend to have poor pharmacokinetics for imaging...
  26. David Kozono; Fiscal Year: 2016
    ..our recently commissioned small animal radiation research platform (SARRP) for CT-guided targeted mouse radiotherapy. Key elements of the career development plan also include courses at the Harvard School of Public Health on ..
  27. Lung Cancer Chemoradiation: Predictors of Survival
    Xifeng Wu; Fiscal Year: 2009
    ..theme of this study is that intrinsic differences in the susceptibility of cells to the genotoxic effects of radiotherapy and chemotherapy modulate toxicity and outcome...
  28. Soy isoflavones to augment radiotherapy of lung carcinoma
    Gilda G Hillman; Fiscal Year: 2012
    ..provided by applicant): Treatment of unresectable locally advanced non-small cell lung cancer includes radiotherapy which is limited by its toxicity to normal lung, particularly when treating larger-volume disease...
  29. Bioactive Peptides for Mitigation of AGS and Acute Radiation Injury
    Lurong Zhang; Fiscal Year: 2010
    ..AGS and ARI, but also be of benefit to millions of cancer patients each year who undergo chemotherapy or radiotherapy which damages the GI and BM systems...
  30. A phase Ib/II study of AZD2171 and radiation for new brain metastases from NSCLC
    APRIL FITZSIMMONS EICHLER; Fiscal Year: 2010
    ..Despite the standard use of whole brain radiotherapy (WBRT), the prognosis of patients with brain metastases remains dismal...
  31. CAMERON JOHN TURTLE; Fiscal Year: 2015
    ..Inflammation induced by conditioning chemo-radiotherapy prior to HSCT could provide the necessary initiating signals that cause loss of TCR regulation or ..
  32. Quiescent Tc17 programmed CD8 T cells and their role in graft versus host disease
    CAMERON JOHN TURTLE; Fiscal Year: 2012
    ..Inflammation induced by conditioning chemo-radiotherapy prior to HSCT could provide the necessary initiating signals that cause loss of TCR regulation or ..
  33. A Novel Therapy for Radiation-Induced Xerostomia Using Human Salivary Stem Cells
    QUYNH THU XUAN LE; Fiscal Year: 2012
    ..Current pharmacologic management of RT-related xerostomia is costly and ineffective. Intensity modulated radiotherapy (IMRT), which aims to spare one parotid gland, has resulted in some improvement of stimulatory salivary ..
  34. Linda A Barlow; Fiscal Year: 2016
    ..In particular, head and neck cancer patients receiving radiotherapy virtually always experience loss or distortion of their sense of taste that can persist for years...
  35. Sandeep Burma; Fiscal Year: 2015
    ..relatively unchanged over the past 40 years despite aggressive therapy that includes surgical resection, radiotherapy and chemotherapy...
  36. The MRAD9 Radioresistance Gene
    Howard B Lieberman; Fiscal Year: 2013
    ..impact on a wide array of important issues, including understanding inherent susceptibility to DNA damage, with implications for radiotherapy, as well as the genetic control of sperm development and male infertility.
  37. Hongbo R Luo; Fiscal Year: 2016
    Project summary Chemo- and radiotherapy are extensively used to treat various hematological malignancies and solid tumors...
  38. FOUR-DIMENSIONAL MRI FOR IMAGE-GUIDED RADIATION THERAPY FOR PANCREATIC CANCER
    Yanle Hu; Fiscal Year: 2013
    ..Despite a high tendency for metastatic spread, radiotherapy plays an important role in the management of locally advanced unresectable pancreatic cancer...
  39. Tej K Pandita; Fiscal Year: 2014
    ..The inability of radiotherapy to control tumor growth is still a daunting clinical problem that leads to the failure of many treatment ..
  40. Effect of Bone Marrow Cells on the Radiosensitivity of Brain and Mouth Cancers
    JOHN MARTIN BROWN; Fiscal Year: 2012
    ..of glioblastoma multiforme (GBM) and of head and neck tumors: human cancers for which the current treatment is radiotherapy (with or without surgery and chemotherapy) and for which treatment failure leading to patient death is largely ..
  41. IVETTE SUAREZ; Fiscal Year: 2015
    ..Since IBC tumor cell emboli are more efficient at forming metastases and are more resistant to chemo and radiotherapy than single cells, it seems feasible to prevent IBC with a compound that has the ability to disintegrate the ..
  42. Antimicrobial and Regenerative Treatment for Oral Mucositis
    SHENDA BAKER; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Oral mucositis is a frequent and painful complication of chemotherapy, radiotherapy and immune compromise...
  43. Discovering Microenvironments Promoting Pathological EMT using Array Technology
    Naira Serobyan; Fiscal Year: 2012
    ..Current conventional therapy - surgery, chemotherapy, radiotherapy, etc...
  44. Expression-Based Multi-Gene Signatures for CRC Recurrence and Chemoselection
    Christopher Sears; Fiscal Year: 2012
    ..response to therapies used to treat post-surgical CRC patients including major chemotherapies and external beam radiotherapy. The initial assay developed and evaluated in Phase II requires only 4 genes to predict recurrence (mCRC) with ..
  45. Translating CBT-Insomnia for Lung Cancer into practice: A RCT
    Grace E Dean; Fiscal Year: 2013
    ..COPD), and the effects of lung cancer treatment, in particular, partial lung resection and postoperative radiotherapy can result in impaired pulmonary function resulting in hyperarousal from pain, cough and dyspnea leading to a ..
  46. Role of EGFR in DNA Repair and Radiation Response in Non Small Cell Lung Cancer
    CHAITANYA SURESH NIRODI; Fiscal Year: 2012
    b>Radiotherapy, either alone, or in combination with chemotherapy, is frequently used in the treatment of patients with non-small cell lung carcinoma...
  47. Novel multivalent/multifunctional agents derived from a humanized anti-insulin-li
    Thomas M Cardillo; Fiscal Year: 2010
    ..It has resisted attempts of curative radiotherapy and chemotherapy...
  48. Jack Roth; Fiscal Year: 2016
    ..Molecular Signatures for Individualizing Lung Cancer;2. Risk Prediction for Platinum-based Chemotherapy and Radiotherapy Outcome in Non-Small Cell Lung Cancer Patients;3. Targeting the Tumor Microenvironment in NSCLC;4...
  49. Treatment of Osteoradionecrosis with Bone Marrow Stromal Cells
    Sunday O Akintoye; Fiscal Year: 2010
    ..In the oro-facial region, osteoradionecrosis is a major complication of head and neck cancer radiotherapy characterized by tissue dehiscence, bone exposure, facial deformities, compromised oro-facial function and ..
  50. Mechanisms of radiosensitization by 2-methoxyestradiol in prostate cancer models
    James M Larner; Fiscal Year: 2012
    ..A promising candidate for enhancement of prostate tumor radiotherapy is the naturally occurring estrogen metabolite, 2-methoxyestradiol (2-ME)...
  51. JAMES MATTHEW BARNES; Fiscal Year: 2015
    ..often have survival rates as low as one year, even after surgical resection of the tumor and combined chemo and radiotherapy. As an example of the unmet therapeutic need for this tumor type, the alkylating agent temozolomide is one of ..
  52. Khaled Hassan; Fiscal Year: 2015
    ..At diagnosis, most patients already have advanced-stage disease and the use of chemotherapy and radiotherapy is rarely curative...
  53. Hua Su; Fiscal Year: 2016
    ..The only options are resection, embolization and radiotherapy, all of which may pose significant risk...
  54. BRENDA MARIE SANDMAIER; Fiscal Year: 2016
    ..The overall goal of this project is to overcome these limitations by delivering targeted anti-CD45 radiotherapy using an ?-emitter, astatine-211 (211At), to sites of disease in dogs with spontaneous lymphoma...
  55. A Novel Testicular Germ Cell Maturation Model for Fertility Preservation in Pre-p
    Kirk C Lo; Fiscal Year: 2012
    ..Treatment modalities such as chemotherapy and radiotherapy can have a profound and irreversible impact on fertility...
  56. HEAT AND RADIATION EFFECTS ON TUMOR MICROCIRCULATION
    Mark Wesley Dewhirst; Fiscal Year: 2013
    ..for how hypoxia and reactive oxygen/nitrogen species (ROS/RNS) regulate blood vessel growth (angiogenesis) and radiotherapy responses, via HIF-1 (hypoxia-inducible factor-1) and VEGF (vascular endothelial growth factor)...
  57. A Modulator of Innate Immunity for Preventing Hospital-Acquired Infections
    James D Thacker; Fiscal Year: 2010
    ..g. neonates, the elderly, chemo- or radiotherapy patients, HIV/AIDS patients)...
  58. 8th Annual Conference on Head and Neck Cancer
    Eben L Rosenthal; Fiscal Year: 2012
    ..molecular genetics, tumor cell biology, immunology, gene therapy, organ-sparing surgery, radiology and imaging, radiotherapy, chemotherapy, chemoprevention, reconstructive surgery, and quality of life issues...
  59. Targeted Radiotherapy with 90Y-BC8 Monclonal Antibody, Fludarabine and TBI Follow
    William I Bensinger; Fiscal Year: 2012
    ..Although 131I has been highly successful with regard to delivering targeted radiotherapy, concerns about safety and the transportability of this technology due to high gamma emissions of 131I and the ..
  60. Human Umami Taste: Genetics of Psychophysical Traits
    Paul A S Breslin; Fiscal Year: 2012
    ..Hence, people who lose their sense of taste, such as radiotherapy patients, suffer nutrionally...
  61. Invasion of glioblastoma multiforme (GBM) cells in organotypic brain slices
    ZEV ARI BINDER; Fiscal Year: 2013
    ..The average survival with surgery, radiotherapy, and chemotherapy is 14.6 months and is often marked by tumor recurrence after treatment...
  62. Predictive Markers in Metastatic Renal Cancer
    Phillip G Febbo; Fiscal Year: 2012
    ..by applicant): Metastatic renal cell carcinoma (RCC) is a dismal disease, with nearly uniform resistance to radiotherapy, chemotherapy and immunotherapy...
  63. Paul Dent; Fiscal Year: 2014
    ..In vivo we have noted in one GBM model that OSU-03012 can enhance animal survival and interact with radiotherapy to further prolong survival...
  64. Suppression of glioma invasion by a bicistronic constuct
    JASTI RAO; Fiscal Year: 2007
    ..These gliomas are highly resistant even to combinations of different therapies such as surgery, radiotherapy, and chemotherapy...
  65. Molecular Epidemiology of Secondary Lung Cancer
    Peter Shields; Fiscal Year: 2007
    Several studies indicate that women with breast cancer who undergo radiotherapy are susceptible to secondary lung cancer, whether they are smokers or nonsmokers...
  66. RADIOPHARMACEUTICALS FOR BREAST TUMOR IMAGING & THERAPY
    John Katzenellenbogen; Fiscal Year: 2006
    ..of estrogens, which if labeled with suitable radionuclides, could be used for diagnostic imaging or radiotherapy or breast tumors...
  67. Nanotechnology enabled desktop image-guided microbeam radiation therapy system
    OTTO Z contact ZHOU; Fiscal Year: 2010
    DESCRIPTION (Provided by the applicant): Today, state-of-the-art radiotherapy provides excellent benefits for patients with early stage and radiosensitive cancers...
  68. DOSIMETRY IN CHILDREN AND YOUNG ADULTS WITH NEUROBLASTOMA OR NEUROENDOCRINE TUMOR
    M SUE O DORISIO; Fiscal Year: 2009
    Molecularly targeted radiotherapy using 131I-MIBG has been demonstrated to improve survival in neuroblastoma, but the dose is limited by bone marrow toxicity...
  69. A Phase II Study to Test the Correlation of a Radiation Pneumonitis Imaging Bioma
    Thomas M Guerrero; Fiscal Year: 2010
    ..RP is the dose limiting toxicity in thoracic radiotherapy for lung cancer making local control (based on bronchoscopic biopsy) achievable in less than 20% of patients...
  70. A Therapeutic Agent for Radiation-induced Lung Fibrosis
    SHUAN HUANG; Fiscal Year: 2009
    ..Lung fibrosis also develops as a consequence of multiple causes, including radiotherapy and chemotherapy for lung neoplasms...
  71. Effectiveness of Early Stage Prostate Cancer Treatment
    MARTIN G contact SANDA; Fiscal Year: 2010
    ..comparing the 3 most common contemporary treatments for early stage prostate cancer: prostatectomy, external radiotherapy, and brachytherapy. We propose to address this knowledge gap to facilitate treatment decisions...
  72. Gene Therapy for Retinoblastoma
    Richard Hurwitz; Fiscal Year: 2003
    ..therapy for retinoblastoma utilizes surgical enucleation with resulting blindness and facial deformities or radiotherapy and chemotherapy that result in both local and systemic toxicity including an increase in the occurrence of ..
  73. SUPERHEATED DROP DETECTORS FOR DOSIMETRY IN RADIOTHERAPY
    Ravinder Nath; Fiscal Year: 2001
    ..neutron-sensitive and photon-insensitive probes for in- vivo measurements of the photoneutron contamination of radiotherapy x-ray beams have been developed...
  74. Development of a canine model of radiotherapy induced oral mucositis
    Dorothy C Brown; Fiscal Year: 2010
    ..Up to 90% of patients with head and neck cancer (HNC) receiving radiotherapy (RT) will develop OM...
  75. PROGNOSTIC BIOMARKERS FOR HEAD AND NECK CANCER
    K Ang; Fiscal Year: 2002
    ..Since treatment consisted of radiotherapy only in all patients, the study population is ideal for addressing the value of EGFR expression in predicting ..
  76. Antioxidant Interactions with Prostate Cancer Treatments
    Kathleen Shiverick; Fiscal Year: 2007
    ..Recent improvements in external beam radiotherapy and interstitial brachytherapy (implantation of radioactive pellets) have made this minimally invasive ..
  77. NEOADJUVANT THERAPY OF OR CANCER BY INHIBITING NF-KAPPAB
    Cun Yu Wang; Fiscal Year: 2003
    ..At advanced stage, p53 is mutated in about 60 percent of tumors and the effectiveness of chemotherapy and radiotherapy has been very disappointing...
  78. Image-guided Adaptive IMRT for Head and Neck Cancer
    David Schwartz; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Current head and neck (H&N) intensity modulated radiotherapy (IMRT) techniques cause severe discomfort and functional morbidity...
  79. MECHANISMS OF CANNABINOID'S ANTIEMETIC ACTIONS
    NISSAR DARMANI; Fiscal Year: 2007
    ..The immediate phase of vomiting induced by chemo- or radiotherapy can be treated with serotonin 5-HT3 receptor antagonists, however, there is currently no clinically available ..