blood specimen collection

Summary

Summary: The taking of a blood sample to determine its character as a whole, to identify levels of its component cells, chemicals, gases, or other constituents, to perform pathological examination, etc.

Top Publications

  1. ncbi Stability of genomic DNA in dried blood spots stored on filter paper
    Sumonta Chaisomchit
    National Institute of Health, Department of Medical Sciences, Ministry of Public Health, Nonthaburi, Thailand
    Southeast Asian J Trop Med Public Health 36:270-3. 2005
  2. ncbi Dried blood spot methods in therapeutic drug monitoring: methods, assays, and pitfalls
    Peter M Edelbroek
    SEIN, Epilepsy Institute, Heemstede, The Netherlands
    Ther Drug Monit 31:327-36. 2009
  3. ncbi Dried blood spots for HIV-1 drug resistance and viral load testing: A review of current knowledge and WHO efforts for global HIV drug resistance surveillance
    Silvia Bertagnolio
    World Health Organization, Geneva, Switzerland
    AIDS Rev 12:195-208. 2010
  4. ncbi Haemolysis: an overview of the leading cause of unsuitable specimens in clinical laboratories
    Giuseppe Lippi
    Clinical Chemistry Laboratory, University of Verona, Verona, Italy
    Clin Chem Lab Med 46:764-72. 2008
  5. ncbi Impact of blood collection devices on clinical chemistry assays
    Raffick A R Bowen
    Department of Pathology, Stanford University, 300 Pasteur Drive, Room H1507 B, Stanford, CA 94305, USA
    Clin Biochem 43:4-25. 2010
  6. pmc Pre-analytical effects of blood sampling and handling in quantitative immunoassays for rheumatoid arthritis
    Xiaoyan Zhao
    Crescendo Bioscience, Inc, South San Francisco, CA 94080, United States
    J Immunol Methods 378:72-80. 2012
  7. ncbi An unusual case of a primary blood collection tube with floating separator gel
    Massimo Daves
    Clinical Biochemical Laboratory, San Maurizio Regional Hospital, Via L Boehler 5, Balzano, Italy
    J Clin Lab Anal 26:246-7. 2012
  8. ncbi A new methodology to preserve the original proportion and integrity of cell-free fetal DNA in maternal plasma during sample processing and storage
    M R Fernando
    Research and Development Division, Streck Inc, La Vista, NE 68128, USA
    Prenat Diagn 30:418-24. 2010
  9. ncbi Evaluation of the Becton-Dickinson rapid serum tube: does it provide a suitable alternative to lithium heparin plasma tubes?
    Goce Dimeski
    School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, Australia
    Clin Chem Lab Med 48:651-7. 2010
  10. ncbi Dried blood spots are a useful tool for quality assurance of rapid HIV testing in Kigali, Rwanda
    P Chaillet
    Medecins Sans Frontieres, Medical Department, Brussels Operational Center, Belgium
    Trans R Soc Trop Med Hyg 103:634-7. 2009

Detail Information

Publications260 found, 100 shown here

  1. ncbi Stability of genomic DNA in dried blood spots stored on filter paper
    Sumonta Chaisomchit
    National Institute of Health, Department of Medical Sciences, Ministry of Public Health, Nonthaburi, Thailand
    Southeast Asian J Trop Med Public Health 36:270-3. 2005
    ..However, DNA quality for amplification of larger DNA fragments decreased when the specimens were stored for longer than 10 years...
  2. ncbi Dried blood spot methods in therapeutic drug monitoring: methods, assays, and pitfalls
    Peter M Edelbroek
    SEIN, Epilepsy Institute, Heemstede, The Netherlands
    Ther Drug Monit 31:327-36. 2009
    ..However, its benefits must be weighed against the degree of potential errors introduced via the sampling method; there is evidently a need for more standardization, quality assurance, basic research, and assay development...
  3. ncbi Dried blood spots for HIV-1 drug resistance and viral load testing: A review of current knowledge and WHO efforts for global HIV drug resistance surveillance
    Silvia Bertagnolio
    World Health Organization, Geneva, Switzerland
    AIDS Rev 12:195-208. 2010
    ....
  4. ncbi Haemolysis: an overview of the leading cause of unsuitable specimens in clinical laboratories
    Giuseppe Lippi
    Clinical Chemistry Laboratory, University of Verona, Verona, Italy
    Clin Chem Lab Med 46:764-72. 2008
    ....
  5. ncbi Impact of blood collection devices on clinical chemistry assays
    Raffick A R Bowen
    Department of Pathology, Stanford University, 300 Pasteur Drive, Room H1507 B, Stanford, CA 94305, USA
    Clin Biochem 43:4-25. 2010
    ..This review will identify sources of exogenous substances in blood specimens and propose methods to minimize their impact on clinical chemistry assays...
  6. pmc Pre-analytical effects of blood sampling and handling in quantitative immunoassays for rheumatoid arthritis
    Xiaoyan Zhao
    Crescendo Bioscience, Inc, South San Francisco, CA 94080, United States
    J Immunol Methods 378:72-80. 2012
    ..These results illustrate the importance of characterizing pre-analytical methodology, sample type, sample processing and handling procedures for clinical testing in order to ensure test accuracy...
  7. ncbi An unusual case of a primary blood collection tube with floating separator gel
    Massimo Daves
    Clinical Biochemical Laboratory, San Maurizio Regional Hospital, Via L Boehler 5, Balzano, Italy
    J Clin Lab Anal 26:246-7. 2012
    ..The aspiration of gel along with the sample matrix might also spuriously modify the test results, since an inappropriate amount of serum or plasma would be analyzed...
  8. ncbi A new methodology to preserve the original proportion and integrity of cell-free fetal DNA in maternal plasma during sample processing and storage
    M R Fernando
    Research and Development Division, Streck Inc, La Vista, NE 68128, USA
    Prenat Diagn 30:418-24. 2010
    ..To develop a standardized blood collection device that preserves fetal cell-free DNA and minimizes the cell-free DNA background in maternal plasma...
  9. ncbi Evaluation of the Becton-Dickinson rapid serum tube: does it provide a suitable alternative to lithium heparin plasma tubes?
    Goce Dimeski
    School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, Australia
    Clin Chem Lab Med 48:651-7. 2010
    ..Although lithium heparin plasma has unique problems, it has become an alternative in hospital-based laboratories...
  10. ncbi Dried blood spots are a useful tool for quality assurance of rapid HIV testing in Kigali, Rwanda
    P Chaillet
    Medecins Sans Frontieres, Medical Department, Brussels Operational Center, Belgium
    Trans R Soc Trop Med Hyg 103:634-7. 2009
    ....
  11. ncbi Optimizing the yield and utility of circulating cell-free DNA from plasma and serum
    Xiaoyan Xue
    Academic Unit of Clinical Oncology, University of Sheffield, Sheffield, UK
    Clin Chim Acta 404:100-4. 2009
    ..We therefore evaluated different aspects of laboratory protocols for the processing and purification of CFDNA in clinical studies...
  12. ncbi Dried fluid spots for HIV type-1 viral load and resistance genotyping: a systematic review
    Raph L Hamers
    PharmAccess Foundation, Center for Poverty related Communicable Diseases, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Antivir Ther 14:619-29. 2009
    ..This report reviews the current evidence for their utility...
  13. ncbi The effect of freezing, thawing, and short- and long-term storage on serum thyrotropin, thyroid hormones, and thyroid autoantibodies: implications for analyzing samples stored in serum banks
    Tuija Männistö
    Clin Chem 53:1986-7. 2007
  14. ncbi Genotyping whole-genome-amplified DNA from 3- to 25-year-old neonatal dried blood spot samples with reference to fresh genomic DNA
    Mads Vilhelm Hollegaard
    Section of Neonatal Screening and Hormones, Statens Serum Institute, Copenhagen, Denmark
    Electrophoresis 30:2532-5. 2009
    ..Based on these results we conclude that DBS samples should be considered a reliable and potential resource for future genotyping studies...
  15. ncbi An improved, simple screening method for detection of glucose-6-phosphate dehydrogenase deficiency
    Indah S Tantular
    Tropical Disease Center and Department of Parasitology, Faculty of Medicine, Airlangga University, Surabaya, Indonesia
    Trop Med Int Health 8:569-74. 2003
    ..As the new method is both qualitative and quantitative, it is possible to express G6PD activity as increase of NADPH concentration by reading absorbance at 460 nm after incubation for 30 or 60 min...
  16. ncbi Preanalytical variables and off-site blood collection: influences on the results of the prothrombin time/international normalized ratio test and implications for monitoring of oral anticoagulant therapy
    Johanna H H van Geest-Daalderop
    Thrombosis Service, Department of Laboratory of Clinical Chemistry and Haematology, Jeroen Bosch Hospital, s Hertogenbosch, The Netherlands
    Clin Chem 51:561-8. 2005
    ..We assessed the effect on PT/INR of preanalytical variables, including ones related to off-site blood collection and transportation to a laboratory...
  17. ncbi PCR assay in malaria diagnosis using filter paper samples from Jazan region, Saudi Arabia
    Saeed A Al-Harthi
    Department of Medical Parasitology, Faculty of Medicine, Umm Al Qura University, Makkah, Kingdom of Saudi Arabia
    J Egypt Soc Parasitol 38:693-706. 2008
    ..PCR sensitivity decreased by using DNA extracted from filter-paper compared to microscopy and whole blood PCR. But the DNA isolated from filter paper detected parasites in many microscopy negative samples...
  18. ncbi Serum 25-hydroxyvitamin D is unaffected by multiple freeze-thaw cycles
    Diana M Antoniucci
    Division of Endocrinology, Department of Medicine, University of California, San Francisco, CA 94105, USA
    Clin Chem 51:258-61. 2005
  19. ncbi Dried blood spots for the diagnosis and quantitation of HIV-1: stability studies and evaluation of sensitivity and specificity for the diagnosis of infant HIV-1 infection in Thailand
    W Leelawiwat
    The Thai Ministry of Public Health U S Centers for Disease Control and Prevention Collaboration, Nonthaburi, Thailand
    J Virol Methods 155:109-17. 2009
    ..These results show that DBS can be used accurately instead of whole blood for the diagnosis of HIV-1 infection and VL quantitation, particularly if samples are appropriately stored...
  20. ncbi Solution densities and estimated total protein contents associated with inappropriate flotation of separator gel in different blood collection tubes
    Ronald C Faught
    Clinical Laboratory, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    Arch Pathol Lab Med 135:1081-4. 2011
    ..In automated analytical systems, gel flotation can lead to mechanical disruption and potential inaccurate result reporting upon aspiration into instrument sampling probes...
  21. ncbi High-sensitivity enzyme immunoassay for C-reactive protein in dried blood spots
    Thomas W McDade
    Laboratory for Human Biology Research, Northwestern University, Evanston, IL 60208, USA
    Clin Chem 50:652-4. 2004
  22. ncbi Evaluation of a new generation of plastic evacuated blood-collection tubes in clinical chemistry, therapeutic drug monitoring, hormone and trace metal analysis
    Jean Marie Boeynaems
    Laboratory of Medical Chemistry, Department of Clinical Pathology, Erasme Hospital, Universite Libre de Bruxelles, Brussels, Belgium
    Clin Chem Lab Med 42:67-71. 2004
    ..These studies demonstrate that VENOSAFE PET tubes are a suitable alternative to glass tubes...
  23. ncbi Comparison of glucose determinations on blood samples collected in three types of tubes
    Geling Li
    Department of Pathology, SUNY Downstate Medical Center, Brooklyn, NY, 11209, USA
    Ann Clin Lab Sci 43:278-84. 2013
    ..These results suggest that red-top tubes with serum separator or grey-top tubes with a fluoride glycolysis inhibitor may be used for reproducible glucose determinations. ..
  24. ncbi The analysis of dried blood spot samples using liquid chromatography tandem mass spectrometry
    Brian G Keevil
    Department of Clinical Biochemistry, University Hospital of South Manchester, UK
    Clin Biochem 44:110-8. 2011
    ..Calibration of assays and the problems with matrix matching of standards are also important issues that need to be addressed before an assay can be used routinely...
  25. ncbi Effect of specimen anticoagulation on the measurement of circulating platelet-derived growth factors
    Robert Zimmermann
    Department of Transfusion Medicine and Hemostaseology, University Hospital Erlangen, Friedrich Alexander University, Germany
    Clin Chem 51:2365-8. 2005
  26. ncbi Commercial enzyme immunoassay adapted for the detection of antibodies to hepatitis C virus in dried blood spots
    Hayley A Croom
    National Serology Reference Laboratory, 4th Floor, Healy Building, 41 Victoria Parade, Melbourne, VIC 3065, Australia
    J Clin Virol 36:68-71. 2006
    ..Consequently, HCV assays are required that produce reliable results using samples derived from DBS...
  27. ncbi Human immunodeficiency virus serotyping on dried serum spots as a screening tool for the surveillance of the AIDS epidemic
    Francis Barin
    Universite Francois Rabelais, Centre National de Référence du VIH and Inserm Espri EA 3856, Tours, France
    J Med Virol 78:S13-8. 2006
    ....
  28. pmc Use of capillary blood samples as a new approach for diagnosis of Dengue virus infection
    Severine Matheus
    Centre National de Référence des Arbovirus, Institut Pasteur de la Guyane, 23 avenue Pasteur, BP 6010, 97306 Cayenne Cedex, French Guiana
    J Clin Microbiol 45:887-90. 2007
    ..Analysis of the viability of viral particles under these conditions may give new insights into the physiopathology of dengue virus infection and the transmission of dengue virus during outbreaks...
  29. ncbi Nursing blood specimen collection techniques and hemolysis rates in an emergency department: analysis of venipuncture versus intravenous catheter collection techniques
    Glynnis Lowe
    Department of Emergency Medicine, York Hospital, York, PA 17405, USA
    J Emerg Nurs 34:26-32. 2008
    ..Our hypothesis was that hemolysis rates of blood specimens differ dependent on the blood collection technique by venipuncture or intravenous catheter draw...
  30. ncbi Evaluation of the BD Vacutainer PST II blood collection tube for special chemistry analytes
    Jeffrey Chance
    BD Diagnostics Preanalytical Systems, Franklin Lakes, NJ, USA
    Clin Chem Lab Med 47:358-61. 2009
    ..The comparison tubes included the BD Vacutainer Serum Plus Tube, the BD Vacutainer Lithium Heparin Plus Tube, and the BD Vacutainer Lithium Heparin Glass Tube...
  31. ncbi Collecting factors related to the haemolysis of blood specimens
    Li Fang
    Department of Nursing, Kaohsiung Armed Forces General Hospital, Kaohsiung, Taiwan
    J Clin Nurs 17:2343-51. 2008
    ..The purpose of the study is to explore the collecting factors for the haemolysis of the blood specimens in a regional hospital in South Taiwan...
  32. pmc Virological surveillance of dengue in Saint Martin and Saint Barthelemy, French West Indies, using blood samples on filter paper
    Severine Matheus
    Laboratoire de Virologie, Centre National de Référence des Arbovirus et Virus Influenza Région Antilles Guyane, Institut Pasteur de la Guyane, Cayenne, French Guiana
    Am J Trop Med Hyg 86:159-65. 2012
    ..This surveillance system offers a low-cost alternative for reinforcing dengue prevention in areas where specialized laboratories do not exist, notably by facilitating the early detection of potentially new dengue serotypes...
  33. ncbi Iodinated contrast media interfere with gel barrier formation in plasma and serum separator tubes
    Tom Spiritus
    Department of Laboratory Medicine Clinical Chemistry, University Hospitals Leuven, Herestraat 49, B 3000 Leuven, Belgium
    Clin Chem 49:1187-9. 2003
  34. ncbi Evaluation of the filter paper blood collection method for detecting Og4C3 circulating antigen in bancroftian filariasis
    J O Gyapong
    Health Research Unit, Ministry of Health, Accra, Ghana
    Trans R Soc Trop Med Hyg 92:407-10. 1998
    ..The diagnostic performance of the method was consistently low in all but 2 communities (sensitivity = 50.3%). This method of diagnosing filariasis is not suitable for field use in its present form...
  35. ncbi Stability studies of twenty-four analytes in human plasma and serum
    Bobby L Boyanton
    Department of Pathology, OU Medical Center, University of Oklahoma Health Sciences Center, PO Box 26307 Oklahoma City, OK 73190, USA
    Clin Chem 48:2242-7. 2002
    ..The stability and stoichiometric changes of analytes in plasma and serum after prolonged contact with blood cells in uncentrifuged Vacutainer tubes were studied...
  36. ncbi Detection of Leishmania in immunocompromised patients using peripheral blood spots on filter paper and the polymerase chain reaction
    L Campino
    Unidade de Leishmanioses Centro de Malária e Outras Doenças Tropicais, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Portugal
    Eur J Clin Microbiol Infect Dis 19:396-8. 2000
    ..The results suggest that the polymerase chain reaction can be used with blood spots on filter paper as an initial screening method for immunocompromised patients suspected to have Leishmania infection...
  37. ncbi Incomplete filling of lithium heparin tubes affects the activity of creatine kinase and gamma-glutamyltransferase
    G Lippi
    U O Diagnostica Ematochimica, Azienda Ospedaliero Universitaria di Parma, Italy
    Br J Biomed Sci 69:67-70. 2012
    ..3% and 16.6% for the half-draw and low-draw tubes, respectively. These results suggest that short-draw lithium heparin tubes might be unsuitable for testing GGT and CK using specific combinations of reagents and instrumentation...
  38. pmc Modified indirect hemagglutination test for detection of treponemal antibodies in finger-prick blood
    J L Backhouse
    Institute of Clinical Pathology and Medical Research, Westmead, New South Wales, Australia
    J Clin Microbiol 30:561-3. 1992
    ..pallidum and 94.8% with the fluorescent treponemal antibody test. The modified hemagglutination test appears to be a simple and economical test that is suitable for use in large epidemiological surveys for yaws...
  39. ncbi Storing newborn blood spots: modern controversies
    Linda Kharaboyan
    Centre de recherche en droit public, University of Montreal
    J Law Med Ethics 32:741-8. 2004
  40. pmc Point-of-care method for total white cell count: an evaluation of the HemoCue WBC device
    A Osei-Bimpong
    Department of Haematology, Hammersmith Hospital, Imperial College Healthcare NHS Trust, London, UK
    Int J Lab Hematol 31:657-64. 2009
    ..4-30.0 x 10(9)/l, except in samples where there are significant numbers of normoblasts or reticulocytes. It is simple to use and provides a valuable advance in the facilities available for POCT in haematology...
  41. ncbi Effects of blood-processing protocols on fetal and total DNA quantification in maternal plasma
    R W Chiu
    Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, 30-32 Ngan Shing Street, Shatin, New Territories, Hong Kong, SAR
    Clin Chem 47:1607-13. 2001
    ..Such preanalytic factors may also affect other applications of plasma DNA analysis...
  42. ncbi Stabilization of mRNA expression in whole blood samples
    Lynne Rainen
    PreAnalytiX CH c o Becton Dickinson, Franklin Lakes, NJ 07417, USA
    Clin Chem 48:1883-90. 2002
    ....
  43. ncbi Changes in concentration of DNA in serum and plasma during storage of blood samples
    Monika Jung
    Clin Chem 49:1028-9. 2003
  44. ncbi Evaluation of the anticoagulants EDTA and citrate, theophylline, adenosine, and dipyridamole (CTAD) for assessing platelet activation on the ADVIA 120 hematology system
    Marion Macey
    Department of Haematology, The Royal London Hospital, Whitechapel, London E1 1BB, United Kingdom
    Clin Chem 48:891-9. 2002
    ..Monitoring of platelet activation by the ADVIA 120 Hematology System requires an anticoagulant and protocol that ensures that platelets are sphered and their activation status is not altered artifactually in vitro...
  45. ncbi Methods to increase the percentage of free fetal DNA recovered from the maternal circulation
    Ravinder Dhallan
    Ravgen Inc, Columbia, MD 21045, USA
    JAMA 291:1114-9. 2004
    ....
  46. ncbi Comparison of indirect immunofluorescence assays for diagnosis of scrub typhus and murine typhus using venous blood and finger prick filter paper blood spots
    Rattanaphone Phetsouvanh
    Wellcome Trust Mahosot Hospital Oxford Tropical Medicine Research Collaboration, Microbiology Laboratory, Mahosot Hospital, Vientiane, Lao People s Democratic Republic
    Am J Trop Med Hyg 80:837-40. 2009
    ..Because filter paper blood samples do not require sophisticated and expensive storage and transport, they may be an appropriate specimen collection technique for the diagnosis of rickettsial disease in the rural tropics...
  47. ncbi Hepatitis B surface antigenaemia and alpha-foetoprotein detection from dried blood spots: applications to field-based studies and to clinical care in hepatitis B virus endemic areas
    M Mendy
    Medical Research Council Fajara, Banjul, The Gambia, West Africa
    J Viral Hepat 12:642-7. 2005
    ..Both research-oriented field studies and routine clinical care may benefit from application of these techniques in resource-limited settings...
  48. ncbi Comparison of blood counts in venous, fingertip and arterial blood and their measurement variation
    Z W Yang
    Morphometric Research Laboratory, North Sichuan Medical College, China
    Clin Lab Haematol 23:155-9. 2001
    ..Elevation of total leucocyte count in the fingertip blood was mainly due to the increase of granulocytes. Measurement with venous blood was of better precision than with fingertip or arterial blood...
  49. ncbi Evaluation of the dried blood spot filter paper technology and five testing strategies of HIV-1 and HIV-2 infections in West Africa
    Ramu Sarge-Njie
    Medical Research Council Laboratories, Fajara, UK
    Scand J Infect Dis 38:1050-6. 2006
    ..The monospecific ELISAs used in this study are no longer in production; currently available differentiating assays need to be tested. DBS are recommended for sentinel surveillance in Africa...
  50. ncbi High specificity of semi-nested multiplex PCR using dried blood spots on DNA Banking Card in comparison with frozen liquid blood for detection of Plasmodium falciparum and Plasmodium vivax
    S Ataei
    Department of Medical and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
    J Clin Lab Anal 25:185-90. 2011
    ..This study was proposed to compare between DNA Banking Card (DBC) filter papers containing dried finger-prick blood and venipunctured frozen liquid blood...
  51. ncbi Effect of blood collection tubes on total triiodothyronine and other laboratory assays
    Raffick A R Bowen
    Clinical Chemistry Service, Department of Laboratory Medicine, Warren Grant Magnuson Clinical Center, NIH, Bethesda, MD 20892 1508, USA
    Clin Chem 51:424-33. 2005
    ..Increased total triiodothyronine (TT(3)) assay results in apparently euthyroid patients triggered an investigation of the effect of blood collection tubes on serum TT(3) and other laboratory assays...
  52. ncbi Newborn screening in Japan
    Kikumaro Aoki
    Kagawa Nutrition University, Saitama, Japan
    Southeast Asian J Trop Med Public Health 34:80. 2003
    ..Parents pay for sample collection. The program is carried out according to law. A new activity involving screening for Wilson disease now necessitates taking dried blood specimens from children 1-3 years old...
  53. ncbi A comparison of glass and plastic blood collection tubes for routine and specialized coagulation assays: a comprehensive study
    Alexander Kratz
    Division of Laboratory Medicine, Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA
    Arch Pathol Lab Med 130:39-44. 2006
    ..Blood collection tubes made from plastic are beginning to replace glass tubes. Coagulation test results can be influenced easily by preanalytic factors, including exposure to surfaces that activate the clotting cascade...
  54. pmc Finger-prick blood samples can be used interchangeably with venous samples for CD4 cell counting indicating their potential for use in CD4 rapid tests
    Calman A MacLennan
    Malawi Liverpool Wellcome Trust Clinical Research Programme, College of Medicine, University of Malawi, Blantyre, Malawi
    AIDS 21:1643-5. 2007
    ..7 and 63.7 cells/microl) for absolute counts and 0.71% (limits of agreement -2.07 and 3.48%) for %CD4/lymphocyte suggesting that finger-prick blood samples can be used interchangeably with venous samples for CD4 cell counting...
  55. ncbi Comparison of soluble thrombomodulin, von Willebrand factor, tPA/PAI-1 complex, and high-sensitivity CRP concentrations in serum, EDTA plasma, citrated plasma, and acidified citrated plasma (Stabilyte) stored at -70 degrees C for 8-11 years
    Torbjörn K Nilsson
    Department of Clinical Chemistry, Orebro University Hospital, Orebro, Sweden
    Thromb Res 116:249-54. 2005
    ..Indeed, using acidified Stabilyte plasma as the single medium would substantially simplify sampling for many epidemiological studies...
  56. ncbi Evaluation of blood collection tubes
    Benoit Polack
    Thromb Res 119:133-4. 2007
  57. ncbi Serum testosterone quantitation by liquid chromatography-tandem mass spectrometry: interference from blood collection tubes
    Run Zhang Shi
    Department of Pathology, Stanford University, Palo Alto, CA, USA
    Clin Biochem 45:1706-9. 2012
    ..We examined a number of commonly used blood collection tubes for the presence of interference and its impact on testosterone quantitation...
  58. pmc Persistence of human immunodeficiency virus type 1 subtype B DNA in dried-blood samples on FTA filter paper
    Chung Chen Li
    Department of Pediatrics, University of Washington, Seattle, USA
    J Clin Microbiol 42:3847-9. 2004
    ..After >4 years of storage at room temperature in the dark our qualitative assay detected virus at a rate similar to that of our initial test (58 of 60, 97%; P = 0.16), suggesting long-term HIV-1 DNA stability...
  59. pmc Evaluation of three parasite lactate dehydrogenase-based rapid diagnostic tests for the diagnosis of falciparum and vivax malaria
    Elizabeth A Ashley
    Epicentre, Paris, France
    Malar J 8:241. 2009
    ..In areas where non-falciparum malaria is common rapid diagnostic tests (RDTs) capable of distinguishing malaria species reliably are needed. Such tests are often based on the detection of parasite lactate dehydrogenase (pLDH)...
  60. ncbi Finger-prick blood collection and computer-assisted enzyme-linked immunosorbent assay for large-scale serological studies on leprosy
    S Chanteau
    Institut Territorial de Recherches Medicales Louis Malarde, Papeete, Tahiti
    Trans R Soc Trop Med Hyg 83:414-6. 1989
    ..Using the method described, as many as 300 samples can be collected in the field and 480 ELISAs per day can be run in the central laboratory by one trained person...
  61. ncbi Evaluation of the human immunodeficiency virus type 1 and 2 antibodies detection in dried whole blood spots (DBS) samples
    Andréa Cauduro de Castro
    Programa de Pós Graduação em Patologia, Fundacao Faculdade Federal de Ciencias Medicas de Porto Alegre, Rua Visconde do Herval 472, Porto Alegre, RS, Brazil
    Rev Inst Med Trop Sao Paulo 50:151-6. 2008
    ..6%, the positive predictive value was 99.5% and negative predictive values were 100%. The results demonstrated high performance characteristics, opening a new perspective of dried whole blood spot utilization in HIV screening diagnosis...
  62. pmc Dried venous blood samples for the detection and quantification of measles IgG using a commercial enzyme immunoassay
    Michaela A Riddell
    Victorian Infectious Diseases Reference Laboratory VIDRL WHO Western Pacific Measles Regional Reference Laboratory, 10 Wreckyn Street, North Melbourne, 3051 Victoria, Australia
    Bull World Health Organ 81:701-7. 2003
    ..To determine whether samples of dried venous blood (DVB) were an acceptable alternative to serum for detecting measles-specific IgG in a commercial enzyme immunoassay...
  63. ncbi A simple method for extraction and purification of genomic DNA from dried blood spots on filter paper
    Sumonta Chaisomchit
    National Institute of Health, Department of Medical Sciences, Ministry of Public Health, Nonthaburi, Thailand
    Southeast Asian J Trop Med Public Health 34:641-5. 2003
    ..Therefore, the method is efficient and appropriate for the extraction and purification of genomic DNA from dried blood specimens, which has become an increasingly important tool for genetic and epidemiological studies...
  64. ncbi Performance of evacuated blood collection tubes at high altitude
    Meaghan J Macnutt
    School of Human Kinetics, University of British Columbia, Vancouver, British Columbia, Canada
    High Alt Med Biol 9:235-7. 2008
    ..With foresight and proper planning, these problems can be avoided, and evacuated blood collection tubes can still be used safely and effectively at high altitude...
  65. ncbi Blood specimen collection methods influence the concentration and the diagnostic validity of matrix metalloproteinase 9 in blood
    K Jung
    Department of Urology, University Hospital Charite, Humboldt University Berlin, Schumannstrasse 20 21, D 10098 Berlin, Germany
    Clin Chim Acta 314:241-4. 2001
    ..To clarify whether the sampling process also influences the diagnostic validity of MMPs, MMP-9 measurements were performed in plasma and serum samples of patients with prostate carcinoma and renal cell cancer...
  66. ncbi A randomized trial of 2% chlorhexidine tincture compared with 10% aqueous povidone-iodine for venipuncture site disinfection: Effects on blood culture contamination rates
    Gompol Suwanpimolkul
    Division of Infectious Diseases, Department of Medicine, Faculty of Medicine, Chulalongkorn University, PhraramIV Road, Pathumwan, Bangkok 10330, Thailand
    J Infect 56:354-9. 2008
    ..Skin antiseptics can prevent blood culture contamination. To our knowledge, there have been no randomized studies to compare 2% alcoholic chlorhexidine and 10% aqueous povidone-iodine for venipuncture site disinfection...
  67. ncbi Preanalytical venous blood sampling practices demand improvement--a survey of test-request management, test-tube labelling and information search procedures
    Olof Wallin
    Department of Medical Biosciences, Clinical Chemistry, Umea University, Umea, Sweden
    Clin Chim Acta 391:91-7. 2008
    ..In the present study, we aimed to survey preanalytical steps in venous blood sampling, prior to actual sample collection. These steps included test-request management and test-tube labelling, as well as information search procedures...
  68. pmc Release of the angiogenic cytokine vascular endothelial growth factor (VEGF) from platelets: significance for VEGF measurements and cancer biology
    R E Banks
    ICRF Cancer Medicine Research Unit, St James s University Hospital, Leeds UK
    Br J Cancer 77:956-64. 1998
    ..e.g. wound healing, and in tumour metastasis, when platelets adhering to circulating tumour cells may release VEGF at points of adhesion to endothelium, leading to hyperpermeability and extravasation of cells...
  69. ncbi Patient-centred care--preanalytical factors demand attention: a questionnaire study of venous blood sampling and specimen handling
    O Wallin
    Department of Medical Biosciences, Clinical Chemistry, Umea University, Umea, Sweden
    Scand J Clin Lab Invest 67:836-47. 2007
    ..This survey of preanalytical procedures was designed to identify sources of error and potential targets for quality improvement strategies...
  70. ncbi Is the test result correct? A questionnaire study of blood collection practices in primary health care
    Johan Söderberg
    Department of Medical Biosciences, Clinical Chemistry, Umea University, Umea, Sweden
    J Eval Clin Pract 16:707-11. 2010
    ..The present study was designed to investigate venous blood sampling (VBS) practices in primary health care centres (PHCs) compared with clinical laboratory staff...
  71. ncbi Evaluation of blood collection tubes using selected reaction monitoring MS: implications for proteomic biomarker studies
    Sarah A Randall
    Department of Chemistry and Biomolecular Sciences, Macquarie University, Sydney, Australia
    Proteomics 10:2050-6. 2010
    ..This study provides useful information for researchers contemplating blood collection for undertaking protein biomarker studies...
  72. ncbi Skin antisepsis kits containing alcohol and chlorhexidine gluconate or tincture of iodine are associated with low rates of blood culture contamination
    Barbara W Trautner
    Department of Medicine, Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas 77030, USA
    Infect Control Hosp Epidemiol 23:397-401. 2002
    ..We assessed blood culture contamination rates associated with the use of skin antisepsis kits containing either 2% alcoholic chlorhexidine gluconate or 2% alcoholic tincture of iodine...
  73. pmc Glycolysis inhibitors negatively bias blood glucose measurements: potential impact on the reported prevalence of diabetes mellitus
    W S Waring
    Clinical Pharmacology Unit, Roche Products, Welwyn Garden City, UK
    J Clin Pathol 60:820-3. 2007
    ..One of these involves addition of glycolysis inhibitors, such as sodium fluoride-potassium oxalate (NaF-KOx) to sample collection tubes, whereas the other requires immediate refrigeration and sample separation...
  74. ncbi Effectiveness of Chloraprep in reduction of blood culture contamination rates in emergency department
    Dwayne Tepus
    Summa Health System, Akron, Ohio 44304, USA
    J Nurs Care Qual 23:272-6. 2008
    ..Adoption of this technique throughout our institution is expected to result in a savings of 875000 dollars per year, as well as decreased discomfort for the patient...
  75. ncbi Acute hepatitis B outbreaks related to fingerstick blood glucose monitoring in two assisted living facilities
    Catherine A Counard
    Communicable Disease Control Unit, Cook County Department of Public Health, Oak Park, Illinois, USA
    J Am Geriatr Soc 58:306-11. 2010
    ..To establish the etiology for outbreaks of hepatitis B virus (HBV) infections at two assisted living facilities (ALFs) and devise appropriate control measures...
  76. ncbi Blood culture contamination rates after skin antisepsis with chlorhexidine gluconate versus povidone-iodine in a pediatric emergency department
    Lauren Marlowe
    University of Pennsylvania School of Medicine, Philadelphia, USA
    Infect Control Hosp Epidemiol 31:171-6. 2010
    ..To determine blood culture contamination rates after skin antisepsis with chlorhexidine, compared with povidone-iodine...
  77. pmc Comparison of chlorhexidine and tincture of iodine for skin antisepsis in preparation for blood sample collection
    Joan Barenfanger
    Laboratory Medicine, Memorial Medical Center, Springfield, Illinois 62781, USA
    J Clin Microbiol 42:2216-7. 2004
    ..7%; for chlorhexidine, it was 3.1%. The 0.41% difference is not statistically significant. Chlorhexidine has comparable effectiveness and is safer, cheaper, and preferred by staff, so it is an alternative to iodine tincture...
  78. ncbi Incident reporting practices in the preanalytical phase: Low reported frequencies in the primary health care setting
    Johan Söderberg
    Department of Medical Biosciences, Clinical Chemistry, Umea University, Umea, Sweden
    Scand J Clin Lab Invest 69:731-5. 2009
    ..However, the practical use of incident reports in this area has not been previously investigated in the primary health care setting, where the majority of the patients come in contact with health care...
  79. doi Stabilization of glucose in blood specimens: mechanism of delay in fluoride inhibition of glycolysis
    Leann M Mikesh
    Clin Chem 54:930-2. 2008
  80. ncbi Effects of a pneumatic tube system on routine and novel hematology and coagulation parameters in healthy volunteers
    Alexander Kratz
    Division of Laboratory Medicine, Department of Pathology, Massachusetts General Hospital, and Harvard Medical School, Boston, USA
    Arch Pathol Lab Med 131:293-6. 2007
    ..The effects of specimen transport through a pneumatic tube system on laboratory results obtained with such modern instruments are unclear...
  81. ncbi Preanalytical errors in primary healthcare: a questionnaire study of information search procedures, test request management and test tube labelling
    Johan Söderberg
    Department of Medical Biosciences, Clinical Chemistry, Umea University, Umea, Sweden
    Clin Chem Lab Med 47:195-201. 2009
    ..This study investigated information search procedures, test request management and test tube labelling in primary healthcare compared to the same procedures amongst clinical laboratory staff...
  82. ncbi Skin antiseptics in venous puncture-site disinfection for prevention of blood culture contamination: systematic review with meta-analysis
    D Caldeira
    Clinical Pharmacology and Therapeutics Laboratory, Faculty of Medicine, Lisbon, Portugal
    J Hosp Infect 77:223-32. 2011
    ..The association of alcohol and povidone-iodine did not seem to be useful. Alcoholic chlorhexidine solutions reduced blood culture false positives compared with aqueous povidone-iodine...
  83. ncbi Dried blood spots, pharmacokinetic studies and better medicines for children
    Hitesh C Pandya
    Department of Infection, Immunity and Inflammation, University of Leicester, Robert Kilpatrick Clinical Sciences Building, Infirmary Square, Leicester, UK
    Bioanalysis 3:779-86. 2011
    ..This article discusses the potential for dried blood spot sampling to offer a solution to this issue...
  84. pmc Comparison of IsoCode STIX and FTA Gene Guard collection matrices as whole-blood storage and processing devices for diagnosis of malaria by PCR
    K J Zhong
    Centre for Travel and Tropical Medicine, Division of Infectious Diseases, Department of Medicine, Toronto General Hospital and the University of Toronto, 200 Elizabeth St, M5G 2C4 Toronto, Ontario, Canada
    J Clin Microbiol 39:1195-6. 2001
    ..However, the detection of mixed infections was suboptimal (IsoCode was 42% sensitive, and FTA was 63% sensitive)...
  85. ncbi DBS sampling can be used to stabilize prodrugs in drug discovery rodent studies without the addition of esterase inhibitors
    Celia J D'Arienzo
    Department of Pharmaceutical Candidate Optimization, Bristol Myers Squibb, Princeton, NJ, USA
    Bioanalysis 2:1415-22. 2010
    ..Dried blood spots (DBS) sampling may offer an alternative prodrug stabilization method for sample collection and storage from rodent studies in drug discovery...
  86. ncbi Logistics and quality control for DNA sampling in large multicenter studies
    R J Nederhand
    Gaubius Laboratory, TNO Prevention and Health, Leiden, The Netherlands
    J Thromb Haemost 1:987-91. 2003
    ..From these results we conclude that transport of non-frozen blood by ordinary mail is usable and practical for DNA isolation for polymerase chain reaction in clinical and epidemiological studies...
  87. ncbi Facilitating pharmacokinetic studies in children: a new use of dried blood spots
    Parul Patel
    School of Pharmacy, De Montfort University, Leicester, UK
    Arch Dis Child 95:484-7. 2010
    ..In this article, we review the DBS technique for performing pharmacokinetic studies and highlight issues that still need to be addressed to establish DBS as a method for performing pharmacokinetic studies in children...
  88. ncbi Simultaneous measurement of 25 inflammatory markers and neurotrophins in neonatal dried blood spots by immunoassay with xMAP technology
    Kristin Skogstrand
    Department of Clinical Biochemistry, Statens Serum Institut, Copenhagen, Denmark
    Clin Chem 51:1854-66. 2005
    ..The small amount of blood available, however, limits the number of analytes that can be determined by traditional immunoassay methodologies...
  89. pmc Implementation of universal newborn bloodspot screening for sickle cell disease and other clinically significant haemoglobinopathies in England: screening results for 2005-7
    A Streetly
    NHS Sickle Cell and Thalassaemia Screening Programme, King s College London School of Medicine, Division of Health and Social Care Research, London, UK
    J Clin Pathol 62:26-30. 2009
    ..Potentially it also offers important lessons for Africa where the World Health Organization is supporting the introduction of newborn screening...
  90. ncbi Use of tandem mass spectrometry for multianalyte screening of dried blood specimens from newborns
    Donald H Chace
    Pediatrix Screening, PO Box 219, 90 Emerson Lane, Bridgeville, PA 15017, USA
    Clin Chem 49:1797-817. 2003
    ....
  91. ncbi Influences of blood sample processing on low-molecular-weight proteome identified by surface-enhanced laser desorption/ionization mass spectrometry
    Rosamonde E Banks
    Cancer Research UK Clinical Centre, St James s University Hospital, Leeds, UK
    Clin Chem 51:1637-49. 2005
    ..The aim of this study was to investigate the potential influence of selected preanalytical factors on the results obtained...
  92. ncbi Storage policies and use of the Danish Newborn Screening Biobank
    B Nørgaard-Pedersen
    Department of Clinical Biochemistry, Statens Serum Institut, Copenhagen, Denmark
    J Inherit Metab Dis 30:530-6. 2007
    ..The Danish NBS-Biobank has been used in several research projects for aetiological studies of a number of disorders, recently employing new sensitive multiplex technologies and genetic analyses utilizing whole-genome amplified DNA...
  93. ncbi Comparing whole-genome amplification methods and sources of biological samples for single-nucleotide polymorphism genotyping
    Ji Wan Park
    Department of Epidemiology, Bloomberg School of Public Health, McKusick Nathans Institute of Genetic Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
    Clin Chem 51:1520-3. 2005
  94. pmc Direct multiplex assay of enzymes in dried blood spots by tandem mass spectrometry for the newborn screening of lysosomal storage disorders
    Michael H Gelb
    Department of Chemistry, University of Washington, Seattle, Washington, USA
    J Inherit Metab Dis 29:397-404. 2006
    ..Several enzymes can be analysed by a single method (multiplex analysis) and in a high-throughput manner appropriate for newborn screening laboratories...
  95. ncbi Determination of oseltamivir (Tamiflu®) and oseltamivir carboxylate in dried blood spots using offline or online extraction
    Katja Heinig
    F Hoffmann La Roche AG, Pharma Research, Nonclinical Drug Safety, Development DMPK Department, Grenzacherstrasse 124, 4070 Basel, Switzerland
    Bioanalysis 3:421-37. 2011
    ..Hence, its feasibility was investigated using a previously developed column-switching LC-MS/MS method...
  96. ncbi Determination of gamma-hydroxybutyric acid in dried blood spots using a simple GC-MS method with direct "on spot" derivatization
    Ann Sofie M E Ingels
    Laboratory of Toxicology, Faculty of Pharmaceutical Sciences, Ghent University, Harelbekestraat 72, 9000 Ghent, Belgium
    Anal Bioanal Chem 398:2173-82. 2010
    ..Our procedure, utilizing the novel approach of direct "on spot" derivatization followed by analysis with GC-MS, proved to be reliable, fast, and applicable in routine toxicology...
  97. ncbi Detection of herpes simplex virus DNA in dried blood spots making a retrospective diagnosis possible
    Ilona Lewensohn-Fuchs
    Department of Immunology, Microbiology and Pathology, Division of Clinical Virology, Karolinska Institutet, F 68 Huddinge University Hospital, 14186 Stockholm, Sweden
    J Clin Virol 26:39-48. 2003
    ....
  98. pmc Direct multiplex assay of lysosomal enzymes in dried blood spots for newborn screening
    Yijun Li
    Department of Chemistry, University of Washington, Seattle 98195, USA
    Clin Chem 50:1785-96. 2004
    ..We describe a multiplex screening method for all five lysosomal enzymes that uses newborn-screening cards containing dried blood spots as the enzyme source...
  99. ncbi Whole genome amplification and genetic analysis after extraction of proteins from dried blood spots
    Mads V Hollegaard
    Clin Chem 53:1161-2. 2007
  100. ncbi Comparison of capillary blood sampling using an automated incision device with and without warming the heel
    Marianne Janes
    The Children s Hospital, Hamilton Health Sciences, Hamilton, ON, Canada, and School of Nursing, McMaster University, Hamilton, ON, Canada
    J Perinatol 22:154-8. 2002
    ..To determine if heel warming prior to heelstick increases the volume of blood collected compared to no warming...
  101. ncbi Modified PAXgene method allows for isolation of high-integrity total RNA from microlitre volumes of mouse whole blood
    J A Krawiec
    Cardiovascular Center for Excellence in Drug Discovery, Department of Vascular Inflammatory Diseases, GlaxoSmithKline Pharmaceuticals, 709 Swedeland Road, King of Prussia, PA 19406, USA
    Lab Anim 43:394-8. 2009
    ..The successful isolation of total RNA from small volumes of mouse whole blood can allow for serial sampling on the same animals, thereby reducing the number of animals required for experimentation...

Research Grants67

  1. Utilizing Saliva to Measure Bone Turnover
    Sreenivas Koka; Fiscal Year: 2007
    ..We anticipate that our results will identify how salivary biomarkers can be used to assess the osseo-status of patients with, or at risk for, osteoporosis. [unreadable] [unreadable] [unreadable] [unreadable]..
  2. Increasing HCV Knowledge & Service Use in Drug Tx Pgms
    Shiela Strauss; Fiscal Year: 2007
    ..In its manualized form, successful elements of the training will be disseminated to programs nationwide ..
  3. Methods for Promoting Public Dialogue on the Use of Residual Newborn Screening Sa
    JEFFREY ROBERT BOTKIN; Fiscal Year: 2010
    ..The project also will compare 3 methods of obtaining public input on this important set of issues. The project is directly relevant to policies in public health departments that affect virtually every newborn in the country. ..
  4. Natural history of acute and chronic HCV in blood donors
    Michael Busch; Fiscal Year: 2008
    ..These investigations will yield important insights into HCV pathogenesis and clarify the natural history of disease for the large number of HCV infected persons identified through donor screening. ..
  5. Aromatase Inhibitor in Males with Adrenal Hyperplasia
    Kyriakie Sarafoglou; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  6. Validity of Preschool Disruptive Behavior Disorders
    KATHRYN KEENAN; Fiscal Year: 2006
    ..If DSM-IV diagnoses of ODD and CD are valid for preschoolers, then etiologic and prevention research must focus on the first years of life. ..
  7. CNS specific Knock-out and Multidrug Transport
    RODNEY HO; Fiscal Year: 2006
    ..The potential benefits to overall biomedical research outweigh the calculated risks associated with this exploratory research. ..
  8. Inflammation and Infection as Risk Factors in Stroke
    Mitchell Elkind; Fiscal Year: 2006
    ..Nationally recognized experts in stroke epidemiology and basic vascular biology will serve as mentors for these studies. ..
  9. Metabolic effects of chemical interactions in toxicity
    Dean Jones; Fiscal Year: 2005
    ....
  10. Metabolic analysis in human sulfur amino acid deficiency
    Dean Jones; Fiscal Year: 2005
    ..g., 300 samples/day with a flow cell), results will show whether this approach could be useful for nutritional assessment of complex metabolic effects of SAA intake. ..
  11. Conference-Safeguarding Adult/Pediatric Stem Cell Donors
    Edward Snyder; Fiscal Year: 2004
    ..This Symposium would address the need for such Standards and stimulate the process. AIM 3 will be to publish a summary of the Symposium in a nationally recognized Journal. ..
  12. REFERENCE LABORATORY TO EVALUATE THERAPIES FOR SCD
    Toshio Asakura; Fiscal Year: 2004
    ..This enhances the likelihood of finding potentially clinically useful compounds. ..
  13. Longitudinal Cancer-Specific Serum Protein Signatures
    Brian Haab; Fiscal Year: 2006
    ..The successful demonstration of the approach to prostate cancer diagnostics will signal its potential usefulness for all types of biomarker studies. [unreadable] [unreadable] [unreadable]..
  14. Defining Secreted Glycan Alterations in Pancreatic Cancer
    Brian Haab; Fiscal Year: 2006
    ..This research could lead to significantly improved blood tests for the detection of cancer, as well as a powerful, generally- applicable platform for studying carbohydrate alterations on multiple proteins. ..
  15. CVD Predictors of Cognitive Function Trajectory over 20 Years
    Elizabeth L Barrett Connor; Fiscal Year: 2010
    ..This information is important given the aging of the population, the fact that CVD risk factors are modifiable, and because the maintenance of cognitive function is an essential component of healthy aging. ..
  16. Natural History and Pathogenesis of WNV in Viremic Dono*
    Michael Busch; Fiscal Year: 2007
    ..abstract_text> ..
  17. Exploring Attitudes About Data Disclosure and Data-Sharing in Genomics Research
    Susanne Haga; Fiscal Year: 2008
    ..The success of large-scale genomics research initiatives will depend on the support and participation of the public and therefore, their views are critically important to obtain. [unreadable] [unreadable] [unreadable]..
  18. Development of an ABO Incompatibility Stop Device (AISD)
    Christopher Hillyer; Fiscal Year: 2008
    ..If the unit is not compatible, the transfusion is not allowed to proceed. This should stop all mistransfusion and the related deaths. [unreadable] [unreadable] [unreadable]..
  19. Reconstitution of Protective CMV Immunity and Immune Regulation After HAART
    Adriana Weinberg; Fiscal Year: 2008
    ..These analyses will define the role of TREG in the inadequate CMV immune reconstitution of HAART recipients. [unreadable] [unreadable] [unreadable] [unreadable]..
  20. Inflammatory and Infectious Burden and Risk of Stroke
    Mitchell Elkind; Fiscal Year: 2008
    ..The cross-sectional associations between inflammatory and infectious markers and quantitative MRI abnormalities will also be assessed. ..
  21. Preadolescent Precursors to Depression in Girls
    KATHRYN KEENAN; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  22. Preventing Adverse Reactions in Novice Blood Donors
    Christopher R France; Fiscal Year: 2010
    ..Because we are working directly with the American Red Cross, our findings can be quickly translated into practice. ..
  23. Outcomes of Sleep Disorders in Older Men
    Elizabeth Barrett Connor; Fiscal Year: 2007
    ..We will also supplement the bank of MrOS specimens to allow for testing of future hypotheses concerning the role of sleep in the development of age-related diseases and conditions. ..
  24. MICROASSAYS FOR ENZYME ACTIVITY
    Wilson Smart; Fiscal Year: 2004
    ..abstract_text> ..
  25. Conference on Drug Against Tropical Protozoan Parasites
    Michael Gelb; Fiscal Year: 2002
    ..We consider the poster sessions that occur throughout our meeting to be just as important as the collection of lecture presentations. ..
  26. BIOCHEMISTRY OF PROTEIN PRENYLATION
    Michael Gelb; Fiscal Year: 2002
    ....
  27. Endogenous/Exogenous Sex Hormones & CHD Risk Factors
    Elizabeth Barrett Connor; Fiscal Year: 2003
    ..These observations may aid in deciding whether individual women should use HRT and, if so, which regimen would provide the most benefit with the least risk. ..
  28. RESEARCH TRAINING IN TRANSFUSION MEDICINE
    Jeffrey McCullough; Fiscal Year: 2003
    ..abstract_text> ..
  29. PILOT TRIAL IN YOUNG PATIENTS WITH IGA NEPHROPATHY
    Ronald Hogg; Fiscal Year: 2002
    ..From these pilot data, we will determine if a full- scale clinical trial is justified and feasible. if this is the case, a competitive renewal application will be submitted to the NIH. ..
  30. Growth Hormone Secretory Dynamics in Peripubertal Girls
    Steven Pincus; Fiscal Year: 2002
    ..In particular, collaborations with pharmaceutical companies who manufacture growth hormone. ..
  31. PREVENTING HIV INFECTION THROUGH BEHAVIOR CHANGE
    Michael Carey; Fiscal Year: 2002
    ....
  32. REGULATION OF HEPATOCELLULAR FUNCTION BY GROWTH HORMONE
    Susan Berry; Fiscal Year: 2002
    ..1 gene expression, defining the IL-6 response element and the nuclear factors binding to Spi 2.1 in response to IL-6 with comparison to the GH response, thereby furthering understanding of the specificity of the Spi 2.1 response to GH. ..
  33. Aptamer Chips for Clinical Monitoring of Target Proteins
    Wilson Smart; Fiscal Year: 2002
    ....
  34. INFANT DYSREGULATION--RISK FACTOR FOR PSYCHOPATHOLOGY
    KATHRYN KEENAN; Fiscal Year: 2002
    ..Ultimately the candidate will test the hypothesis that treatment of early signs of dysregulation will prevent the development of mental disorders in children. ..
  35. NOVEL APPROACHES TO IMPROVE AND EXTEND PLATELET STORAGE
    Sherrill Slichter; Fiscal Year: 2001
    ....
  36. PCR Screening for CMV in Umbilical Cord Blood Stem Cells
    Christopher Hillyer; Fiscal Year: 2003
    ....
  37. Novel Approaches to the Assessment of Oral Mucosal Immu*
    Theresa Whiteside; Fiscal Year: 2003
    ..A better understanding of oral immunity in normal and HIV-infected mucosa is important for the development of new antiviral therapies, including oral antiviral vaccines. ..
  38. HYPERTENSION, RISK FOR HYPERTENSION AND HYPOALGESIA
    Christopher France; Fiscal Year: 2003
    ..This information could be used to identify the best candidates for behavioral and other risk reduction efforts. ..
  39. MULTIPLEX ANALYSIS OF INBORN ERRORS OF METABOLISM
    Michael Gelb; Fiscal Year: 2001
    ..abstract_text> ..
  40. Mechanisms and clinical effects of microchimerism in transfused trauma patients
    MICHAEL PAUL BUSCH; Fiscal Year: 2010
    ..TA-MC also offers an opportunity to better understand, and potentially exploit, injury-induced tolerance for future therapeutic purposes. ..
  41. DNA-Based Vaccines for Oral Carcnoma
    Theresa Whiteside; Fiscal Year: 2005
    ....
  42. GENDER DIFFERENCES IN OSTEOPOROSIS
    Elizabeth Barrett Connor; Fiscal Year: 2002
    ....
  43. Kinetic Biomarker for CLL Prognosis
    Scott Turner; Fiscal Year: 2007
    ..abstract_text> ..
  44. High fat feeding and intramyocellular lipid abnormality
    ZengKui Guo; Fiscal Year: 2005
    ..Thus, the proposed research will improve the understanding of the mechanism of insulin resistance and imcTG abnormalities in the obese rat that will benefit investigation of human obesity. ..
  45. Improving informed consent in Alzheimer disease research
    Jason Karlawish; Fiscal Year: 2006
    ..The results will also begin to elucidate how experts make judgments of competency. [unreadable] [unreadable] [unreadable]..
  46. Folate Polymorphisms, Dietary Folate and Prostate Cancer
    Victoria Stevens; Fiscal Year: 2005
    ..The results of this study are expected to indicate the importance of folate for prostate cancer and whether changing folate consumption can modify the risk associated with genetic variants in the pathway for folate metabolism. ..
  47. Liquid Chromatography Mass Spectrometry system
    Adrian Franke; Fiscal Year: 2005
    ..abstract_text> ..
  48. BIOCHEMICAL STUDIES OF 14 KDA PHOSPHOLIPASES A2
    Michael Gelb; Fiscal Year: 2006
    ..These studies will contribute to our fundamental understanding of how mammalian cells initiate the eicosanoid cascade. ..
  49. Levels of Inflammatory Markers in Treatment of Stroke
    Mitchell Elkind; Fiscal Year: 2008
    ..abstract_text> ..
  50. Consent Methods and Participation in Geriatric Clinical Research
    Jason Karlawish; Fiscal Year: 2009
    ..These results will assist researchers and proxies in conducting subject-centered informed consent discussions. ..
  51. Effect of Antioxidants on Inflammatory Markers and FMVD
    Christopher Gardner; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  52. Potential mechanism(s) of impaired pulsatile insulin secretion and action in Type
    ALEKSEY MATVEYENKO; Fiscal Year: 2008
    ..Specific Aim 3 will be undertaken with the additional guidance of Dr. Morris White at the Howard Hughes Medical Institute. [unreadable] [unreadable] [unreadable]..
  53. The Role of Prolactin in the Etiology of Postmenopausal Breast Cancer
    Shelley Tworoger; Fiscal Year: 2008
    ..This potentially may affect public health by increasing our understanding of how breast cancer develops, which in turn can lead to a better understanding of how to prevent this disease. [unreadable] [unreadable]..
  54. Benefits & Risks of Popular Weight Loss Diets
    Christopher Gardner; Fiscal Year: 2003
    ..The data generated from this preliminary/feasibility study will be used to strengthen the proposal and design of a future full-scale study. ..
  55. COMMUNITY EQUIPOISE AND THE ETHICS OF CLINICAL RESEARCH
    Jason Karlawish; Fiscal Year: 2002
    ..Karlawish advanced training in bioethics scholarship. Other sponsors include experts in clinical trial design, Alzheimers Disease research and empirical research in research ethics. ..
  56. ALA & EPA/DHA (w-3) Effects On Inflammatory Markers in Insulin Resistant Adults
    Christopher Gardner; Fiscal Year: 2007
    ..The adults with the metabolic syndrome selected for this study are those that are at increased risk of heart disease, and those most likely to be benefit from the different therapies tested. [unreadable] [unreadable] [unreadable]..
  57. Fusion Proteins As Probes of P450 Structure and Function
    Richard Auchus; Fiscal Year: 2004
    ..In addition, this approach might be generally applicable to structural studies of membrane-bound proteins. ..
  58. CASE CONTROL STUDY OF RISK FACTORS FOR WILMS TUMOR
    Andrew Olshan; Fiscal Year: 2002
    ..This study will provide important new advances in our understanding of Wilms tumor given the study size, quality of exposure assessment, and incorporation of clinical and biological markers of etiologic heterogeneity. ..
  59. Gene Environment Interaction in Head and Neck Cancer
    Andrew Olshan; Fiscal Year: 2005
    ..The proposed study should contribute knowledge on gene-environment interactions for cancer of the head and neck, but also for other tobacco- and alcohol-related cancers and possibly cancers of unknown etiology. ..
  60. SECONDARY PREVENTION TRIAL OF VENOUS THROMBOSIS
    Paul Ridker; Fiscal Year: 2002
    ....
  61. Bio-Psych Stress Measure Associations and Preterm Birth
    Gwen Latendresse; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  62. THROMBOTIC, INFLAMMATORY & GENE MARKERS OF CVD IN WOMEN
    Paul Ridker; Fiscal Year: 2002
    ....
  63. Comparing Effects of 3 Sources of Garlic on Serum Lipids
    Christopher Gardner; Fiscal Year: 2005
    ..The comprehensive approach taken in this study will provide important evidence for both the public and for health professionals as to whether fresh garlic or garlic supplements have beneficial effects on serum lipids. ..