Genomes and Genes
Summary: Incision of tissues for injection of medication or for other diagnostic or therapeutic procedures. Punctures of the skin, for example may be used for diagnostic drainage; of blood vessels for diagnostic imaging procedures.
Publications231 found, 100 shown here
- Cecal ligation and puncture with total parenteral nutrition: a clinically relevant model of the metabolic, hormonal, and inflammatory dysfunction associated with critical illnessJosef G Heuer
Biotechnology Discovery Research, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana 46285, USA
J Surg Res 121:178-86. 2004..Accordingly, we sought to develop a model of rat CLP with prolonged hyperglycemia through continuous infusion of total parenteral nutrition (TPN) post CLP...
- Bleomycin in the treatment of keloids and hypertrophic scars by multiple needle puncturesA Espana
Department of Dermatology, University Clinic of Navarra, School of Medicine, University of Navarra, Navarra, Spain
Dermatol Surg 27:23-7. 2001..The treatment of keloids and hypertrophic scars has been difficult and a recent French study showed that bleomycin has been useful in the treatment of these lesions...
- Adoptive transfer of in vitro-stimulated CD4+CD25+ regulatory T cells increases bacterial clearance and improves survival in polymicrobial sepsisJosef G Heuer
Biotechnology Discovery Research, Lilly Corporate Center, Indianapolis, IN 46285, USA
J Immunol 174:7141-6. 2005..More importantly, adoptive transfer of in vitro-stimulated Tregs significantly improved bacterial clearance, which resulted in improved survival. Our results suggest a novel role for Tregs in sepsis...
- Cecal ligation and puncture as a model of sepsis in the rat: influence of the puncture size on mortality, bacteremia, endotoxemia and tumor necrosis factor alpha levelsE Otero-Anton
Department of Medicine, Complejo Hospitalario Universitario, Santiago de Compostela, Spain
Eur Surg Res 33:77-9. 2001..Cecal ligation and puncture is a widely used experimental model of sepsis...
- Increased sarcolemmal permeability as an early event in experimental septic cardiomyopathy: a potential role for oxidative damage to lipids and proteinsMara R N Celes
Department of Pathology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Sao Paulo, Brazil
Shock 33:322-31. 2010....
- Complement-induced impairment of innate immunity during sepsisMarkus S Huber-Lang
Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
J Immunol 169:3223-31. 2002..These data identify a molecular basis for defective innate immunity involving neutrophils during sepsis...
- Arterial puncture closing devices compared with standard manual compression after cardiac catheterization: systematic review and meta-analysisMaria Koreny
Department of Emergency Medicine, University of Vienna, Vienna General Hospital, Vienna, Austria
JAMA 291:350-7. 2004..Arterial puncture closing devices (APCDs) were developed to replace standard compression at the puncture site and to shorten bed rest following percutaneous coronary intervention...
- Interatrial septum thickness and difficulty with transseptal puncture during redo catheter ablation of atrial fibrillationDavid R Tomlinson
Department of Cardiac Rhythm Management, John Radcliffe Hospital, Oxford, United Kingdom
Pacing Clin Electrophysiol 31:1606-11. 2008..Patients undergoing catheter ablation for atrial fibrillation (AF) frequently require redo procedures, but there are no data reporting interatrial septum thickness (IAS) and difficulty during repeat transseptal puncture (TSP)...
- Multicenter evaluation of a new laser guidance system for computed tomography interventionK Brabrand
Department of Radiology, Rikshospitalet University Hospital, Oslo, Norway
Acta Radiol 45:308-12. 2004To measure the accuracy of laser-guided punctures and to evaluate the usefulness of the developed laser-guided system.
- Percutaneous punctures with MR imaging guidance: comparison between MR imaging-enhanced fluoroscopic guidance and real-time MR Imaging guidanceBernhard Christian Meyer
Department of Radiology, Hannover Medical School, Carl Neuberg Str 1, 30625 Hannover, Germany
Radiology 266:912-9. 2013..To evaluate and compare the technical accuracy and feasibility of magnetic resonance (MR) imaging-enhanced fluoroscopic guidance and real-time MR imaging guidance for percutaneous puncture procedures in phantoms and animals...
- Use of local anesthesia for arterial puncturesTimothy L Hudson
US Army, Fort Bragg, NC 28307, USA
Am J Crit Care 15:595-9. 2006..Arterial puncture is a source of pain and discomfort. Intradermal injection of lidocaine around the puncture site decreases the incidence and severity of localized pain when used before arterial puncture...
- A conservative approach to performing transseptal punctures without the use of intracardiac echocardiography: stepwise approach with real-time video clipsAlan Cheng
Department of Medicine, Division of Cardiology, Section for Cardiac Electrophysiology, The Johns Hopkins Hospital, Baltimore, Maryland, USA
J Cardiovasc Electrophysiol 18:686-9. 2007..The aim of this brief report is to describe in detail our technique for performing transseptal punctures during catheter ablation procedures for atrial fibrillation...
- Altered neutrophil trafficking during sepsisRen Feng Guo
Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109 0602, USA
J Immunol 169:307-14. 2002..These data suggest that sepsis causes enhanced neutrophil trafficking into the lung via mechanisms that are not engaged in the nonseptic state...
- Ultrasonography-guided punctures-with and without puncture guideMahesh Desai
Department of Urology, Muljibhai Patel Urological Hospital, Gujarat, India
J Endourol 23:1641-3. 2009..We think the punctures with this technique are suboptimal. Both methods need a certain degree of training and orientation...
- Radiofrequency puncture of the fossa ovalis for resistant transseptal accessSebastien Knecht
Hôpital Cardiologique du Haut Lévêque and the Université Victor Segalen Bordeaux II, Bordeaux, France
Circ Arrhythm Electrophysiol 1:169-74. 2008..We evaluated the efficacy and safety of a new method to cross-resistant septae by transmitting radiofrequency (RF) energy through the transseptal needle...
- Cryptococcal meningitis management in Tanzania with strict schedule of serial lumber punctures using intravenous tubing sets: an operational research studyJohn Meda
Department of Internal Medicine, Dodoma University, Dodoma, Tanzania Department of Internal Medicine, Bugando Medical Centre, Mwanza, Tanzania Department of Internal Medicine, Weill Bugando School of Medicine, Mwanza, Tanzania Department of Medicine, Center for Global Health, Weill Cornell Medical College, New York, NY Department of Internal Medicine, Muhimbili National Hospital, Dar es Salaam, Tanzania and Departments of Microbiology Biochemistry, Catholic University of Health and Allied Sciences Bugando, Mwanza, Tanzania
J Acquir Immune Defic Syndr 66:e31-6. 2014..Controlling intracranial pressure (ICP) is essential in CM, but it is difficult in low-income countries because manometers and practical ICP management protocols are lacking...
- Incidence of tissue coring during transseptal catheterization when using electrocautery and a standard transseptal needleEugene Greenstein
Division of Cardiology, Department of Internal Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
Circ Arrhythm Electrophysiol 5:341-4. 2012..The purpose of this study was to determine the incidence of cardiac tissue coring when this technique is used...
- The use of a novel nitinol guidewire to facilitate transseptal puncture and left atrial catheterization for catheter ablation proceduresVineet Wadehra
The Heart Hospital, University College London Hospitals NHS Foundation Trust, 16 18 Westmoreland Street, London W1G 8PH, UK
Europace 13:1401-5. 2011An increasing number of transseptal punctures (TSPs) are performed worldwide for atrial ablations. Transseptal punctures can be complex and can be associated with potentially life threatening complications...
- Transcatheter creation of atrial septal perforation using a radiofrequency transseptal system: novel approach as an alternative to transseptal needle punctureYoshihito Sakata
Evanston Northwestern Healthcare, Evanston, IL 60201, USA
Catheter Cardiovasc Interv 64:327-32. 2005..We applied this technique to a series of patients and evaluated its feasibility as an alternative to conventional transseptal needle puncture...
- Evaluation of voice prosthesis placement at the time of primary tracheoesophageal puncture with total laryngectomyDaniel G Deschler
Massachusetts Eye and Ear Infirmary, Division of Head and Neck Surgery, Department of Otology and Laryngology, Harvard Medical School, Boston 02114, Massachusetts, USA
Laryngoscope 119:1353-7. 2009....
- Simplified technique of tracheoesophageal prosthesis placement at the time of secondary tracheoesophageal puncture (TEP)Daniel G Deschler
Massachusetts Eye and Ear Infirmary, Division of Head and Neck Surgery, Department of Otology and Laryngology, Harvard Medical School, Boston, Massachusetts, USA
Laryngoscope 121:1855-9. 2011..We describe the technique and evaluate the success and potential advantages...
- Efficient reduction of stimulus artefact in TMS-EEG by epithelial short-circuiting by mini-puncturesP Julkunen
Department of Clinical Neurophysiology, Kuopio University Hospital, P O Box 1777, FI 70211 Kuopio, Finland
Clin Neurophysiol 119:475-81. 2008..We aimed at comparing the effects of two different electrode-to-skin contact preparation techniques on the stimulus artefact induced by transcranial magnetic stimulation (TMS) in electroencephalography (EEG) signals...
- Repeat transseptal catheterization after ablation for atrial fibrillationGregory M Marcus
Division of Cardiology, Electrophysiology Section, University of California, San Francisco, California 94143 1354, USA
J Cardiovasc Electrophysiol 18:55-9. 2007..The aim of this study was to determine the difficulty and/or success rates of repeat transseptal catheterization after left atrial ablation for AF...
- Repetitive low-volume blood sampling method as a feasible monitoring tool in a mouse model of sepsisKatrin M Weixelbaumer
Ludwig Boltzmann Institute for Experimental and Clinical Traumatology in the Trauma Research Center of AUVA, Vienna, Austria
Shock 34:420-6. 2010..9; slope, ≥0.9), except lymphocytes (r > 0.5; slope, >0.5). This method provides a feasible and safe translation of clinically relevant daily immunomonitoring to the mouse sepsis model...
- Relationship between cytokine mRNA expression and organ damage following cecal ligation and punctureRong Qian Wu
Institute of Surgical Research, General Hospital of PLA, Beijing 100853, China
World J Gastroenterol 8:131-4. 2002..To investigate the role of cytokine gene expression in organ damage at different tissue sites during sepsis...
- Methyl-2-acetamidoacrylate, an ethyl pyruvate analog, decreases sepsis-induced acute kidney injury in miceAsada Leelahavanichkul
NIH NIDDK, Bldg 10, Rm 3N108, 10 Center Drive, MSC 1268, Bethesda, MD 20892 1268, USA
Am J Physiol Renal Physiol 295:F1825-35. 2008..Identifying this new target and downstream signaling pathways could lengthen the therapeutic window and improve combination therapy with chloroquine...
- Complications of laparoscopic surgery: How to avoid them and how to repair themGerald J Shirk
Department of Obstetrics and Gynecology, Roy and Lucille Carver Medical School, University of Iowa, Iowa City, Iowa, USA
J Minim Invasive Gynecol 13:352-9; quiz 360-1. 2006
- Predictors of complications and learning curve using the Angio-Seal closure device following interventional and diagnostic catheterizationB S Warren
Department of Chemistry, Carleton College, Northfield, Minnesota, USA
Catheter Cardiovasc Interv 48:162-6. 1999..009) and failure to deploy was independent of sheath size used. Angio-Seal can be used with reasonable safety and efficacy immediately after diagnostic and interventional procedures. Cathet. Cardiovasc. Intervent. 48:162-166, 1999...
- Use of a collagen-based device for closure of low brachial artery puncturesA Belenky
Department of Interventional Radiology, Rabin Medical Center, Beilinson and Glolda Campuses, Petah Tiqwa, Sakler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
Cardiovasc Intervent Radiol 30:273-5. 2007..To report our experience with the Angioseal vascular closure device for hemostasis of distal brachial artery puncture...
- Development of a new support method for transpedicular punctures of the vertebral body: the isocenter puncture methodKenji Takizawa
Department of Radiology, St Marianna University School of Medicine, Sugao, Miyamae, Kawasaki, Kanagawa, Japan
Cardiovasc Intervent Radiol 30:757-60. 2007
- Effects of a membrane-permeable radical scavenger, Tempol, on healing of colonic anastomoses in the cecal ligation and puncture model of polymicrobial sepsis in ratsFaruk Onder Aytekin
Faculty of Medicine, Department of General Surgery, Pamukkale University, 20070 Kinikli, Denizli, Turkey
Am J Surg 193:723-9. 2007..In this study we aimed to investigate the effects of Tempol on the healing of colonic anastomoses in the presence of polymicrobial sepsis...
- Recorded maternal voice for preterm neonates undergoing heel lanceC Celeste Johnston
McGill University Health Center, Montreal, Quebec, Canada
Adv Neonatal Care 7:258-66. 2007..To determine if a recording of a mother's voice talking soothingly to her baby is useful in diminishing pain in newborns born between 32 and 36 weeks' gestational age (GA) during routine painful procedures...
- The efficacy of non-pharmacological interventions in the management of procedural pain in preterm and term neonates. A systematic literature reviewEva Cignacco
Department for Obstetrics and Neonatology, Women s and Children s Clinic, University Hospital Insel, Bern, Effingerstr 102, CH 3010 Bern, Switzerland
Eur J Pain 11:139-52. 2007..Non-pharmacological treatment methods are being increasingly discussed with regard to pain prevention and relief either alone or in combination with pharmacological treatment...
- Anterior stromal puncture for recurrent corneal erosion after laser in situ keratomileusisMonika A Malecha
Department of Ophthalmology, University of Tennessee Health Science Center, Memphis, TN 38163, USA
J Cataract Refract Surg 30:496-8. 2004..The secondary DLK resolved quickly after the erosion healed, without the need for topical corticosteroids. Anterior stromal puncture may be a useful treatment for recurrent corneal erosions that do not respond to conventional therapy...
- In vivo observation of mesenteric leukocyte-endothelial interactions after cecal ligation/puncture and surgical sepsis source controlNaomi K Nakagawa
Research Division, Heart Institute, InCor, University of Sao Paulo School of Medicine, Sao Paulo, SP, Brazil
Clinics (Sao Paulo) 62:321-6. 2007..The aim of this study was to evaluate leukocyte-endothelial interactions in the rat mesentery in vivo after CLP and REL...
- Breastfeeding or breast milk for procedural pain in neonatesP S Shah
University of Toronto, Department of Paediatrics and Department of Health Policy, Management and Evaluation, Rm 775A, 600 University Avenue, Toronto, Ontario, Canada M5G 1XB
Cochrane Database Syst Rev 3:CD004950. 2006..Nonpharmacological measures (such as holding, swaddling, breastfeeding) and pharmacological measures (such as acetaminophen, sucrose and opioids) have been used for this purpose...
- Breastfeeding is analgesic in healthy newbornsLarry Gray
Section of Behavioral and Developmental Pediatrics, University of Chicago, Comers Children s Hospital, Chicago, Illinois 60637 1470, USA
Pediatrics 109:590-3. 2002..This study identifies a behavioral and nonpharmacologic means of preventing newborn pain...
- Enhanced kangaroo mother care for heel lance in preterm neonates: a crossover trialC C Johnston
School of Nursing, McGill University, Montreal, QC, Canada
J Perinatol 29:51-6. 2009..To test if enhancing maternal skin-to-skin contact, or kangaroo mother care (KMC) by adding rocking, singing and sucking is more efficacious than simple KMC for procedural pain in preterm neonates...
- Bacteriology and antimicrobial susceptibility of pediatric chronic rhinosinusitis: a 6-year result of maxillary sinus puncturesChung Han Hsin
Department of Otolaryngology, Chung Shan Medical University Hospital and School of Medicine, Taichung, Taiwan
Am J Otolaryngol 31:145-9. 2010..This study aimed to characterize organisms cultured from pediatric chronic rhinosinusitis, as well as current resistance patterns of pathogens...
- Treatment of type II endoleaks after endovascular repair of abdominal aortic aneurysms: translumbar puncture and injection of thrombin into the aneurysm sacR Rial
Department of Vascular Surgery, Hospital Clinico San Carlos, Universidad Complutense, Madrid, Spain
Eur J Vasc Endovasc Surg 27:333-5. 2004..The aim of this article is to report our experience in the use of a new technique for the treatment of type II endoleaks which appear after the endovascular treatment of abdominal aortic aneurysms...
- Management of pain from heel lance with lidocaine-prilocaine (EMLA) cream: is it safe and efficacious in preterm infants?B Stevens
Faculties of Nursing and Medicine, University of Toronto, Department of Pediatrics, The Hospital for Sick Children, Ontario, Canada
J Dev Behav Pediatr 20:216-21. 1999..The authors conclude that EMLA is safe but not efficacious for relieving pain from heel lance in preterm infants...
- Laparoscopic ovarian drilling in the treatment of polycystic ovary syndrome: how many punctures per ovary are needed to improve the reproductive outcome?Hasan Y Malkawi
King Hussein Medical Center, Department of Obstetrics and Gynecology, Infertility Clinic, Amman, Jordan
J Obstet Gynaecol Res 31:115-9. 2005To evaluate the biochemical, clinical and reproductive results after laparoscopic ovarian drilling that carried out a different number of punctures in the ovaries.
- Femoral artery stenosis following percutaneous closure using a starclose closure deviceClare Louise Bent
Department of Diagnostic Imaging, Barts and The London NHS Trust, Whitechapel, London, E1 1BB, UK
Cardiovasc Intervent Radiol 31:814-6. 2008..A Starclose femoral artery closure device was used to achieve hemostasis with subsequent femoral artery stenosis...
- Comparison of arterial closure devices in antegrade and retrograde puncturesAlbert Ho Yuen Chiu
Department of Radiology, Sir Charles Gairdner Hospital, Perth, Australia
J Endovasc Ther 15:315-21. 2008To compare the efficacy, primary failure rates, and complications for the Angio-Seal and Perclose closure devices in antegrade and retrograde common femoral artery (CFA) punctures during peripheral angioplasty procedures.
- Infectious complications related to the use of the angio-seal hemostatic puncture closure deviceC L Cooper
Department of Internal Medicine, Section of Infectious Diseases, University of Manitoba, Winnipeg, Manitoba, Canada
Catheter Cardiovasc Interv 48:301-3. 1999....
- Initial experience using a radiofrequency powered transseptal needleMatthew P Smelley
Section of Cardiology, Department of Internal Medicine, University of Chicago, Chicago, Illinois, USA
J Cardiovasc Electrophysiol 21:423-7. 2010..The purpose of this study was to determine the safety and efficacy of using a novel radiofrequency (RF) powered transseptal needle to perform transseptal puncture (TSP)...
- Do iatrogenic punctures of the labrum affect the clinical results of hip arthroscopy?John S Badylak
Division of Sports Medicine, Department of Orthopaedics and Rehabilitation, University of Wisconsin, Madison, WI 53792 7375, USA
Arthroscopy 27:761-7. 2011To document the effect of iatrogenic labral punctures (ILPs) on the clinical results of hip arthroscopy.
- Patient tolerance and resource utilization associated with an arterial closure versus an external compression device after percutaneous coronary interventionCraig P Juergens
Department of Cardiology, Liverpool Hospital, Liverpool, New South Wales, Australia
Catheter Cardiovasc Interv 63:166-70. 2004..However, patients receiving the AngioSeal were able to ambulate sooner and reported less pain, which may justify the increased costs involved...
- Vascular complications after percutaneous coronary interventions following hemostasis with manual compression versus arteriotomy closure devicesG Dangas
Cardiovascular Research Foundation, Lenox Hill Heart and Vascular Institute, New York, New York, USA
J Am Coll Cardiol 38:638-41. 2001..5 vs. 1.5%, p = 0.03). CONCLUSIONS: In this early experience with ACD after PCI, their use was associated with higher vascular complication rates than hemostasis with manual compression...
- Use of FemoStop system for arterial puncture site closure after coronary angioplastyM Kunert
Department of Cardiology, Marienhospital Bottrop, Germany
J Invasive Cardiol 16:240-2. 2004..5% versus 3.1%; p<0.05). In the clinical setting of intensive heparin anticoagulation and early sheath removal after PTCA (<8 hours), the FemoStop system cannot be recommended due to prolonged femoral artery compression times...
- Glove punctures and postoperative skin flora of hands in cardiac surgeryAnne M Eklund
Department of Cardiothoracic Surgery, Helsinki University Central Hospital, Finland
Ann Thorac Surg 74:149-53. 2002..Surgical gloves are frequently perforated during operations, including heart operations. This infection risk factor is inadequately studied...
- Caecal ligation and puncture in the rat mimics the pathophysiological changes in human sepsis and causes multi-organ dysfunctionH F Brooks
Division of Basic Medical Sciences and Image Resource Facility, St George s University of London, Cranmer Terrace, Tooting, London, UK
Metab Brain Dis 22:353-73. 2007..It appears to be the best available animal model currently available, in which to investigate the underlying pathophysiology of sepsis and identify therapeutic targets...
- Kangaroo mother care diminishes pain from heel lance in very preterm neonates: a crossover trialC Celeste Johnston
School of Nursing, McGill University, Montreal, Canada
BMC Pediatr 8:13. 2008..The purpose of this study was to determine if KMC would also be efficacious in very preterm neonates...
- Peroxynitrite mediates the failure of neutrophil migration in severe polymicrobial sepsis in miceD Torres-Dueñas
Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Avenida Bandeirantes, 3900, Ribeirao Preto, Sao Paulo, Brazil
Br J Pharmacol 152:341-52. 2007..The present study addresses the possibility that peroxynitrite (ONOO(-)), a NO-derived powerful oxidizing and nitrating compound, could also be involved in neutrophil migration failure...
- Early mobilization after percutaneous catheterization and vascular closure with a novel device (Star-Close)Alessandro Desideri
Cardiovascular Research Foundation, S Giacomo Hospital, Castelfranco Veneto, Italy
Am J Cardiol 96:1408-9. 2005..Unsuccessful device deployment occurred in 5 patients. We conclude that Star-Close is a novel arteriotomy closure device that, in selected patients, is safe and allows early deambulation after diagnostic cardiac catheterization...
- Sophorolipids block lethal effects of septic shock in rats in a cecal ligation and puncture model of experimental sepsisMartin H Bluth
SUNY Downstate Medical Center, Department of Surgery, Brooklyn, NY 11203, USA
Crit Care Med 34:188-95. 2006..The potential of the therapeutic effect of sophorolipids was investigated in vivo in a rat model of sepsis and in vitro by analysis of nitric oxide and cytokine production...
- Changes in the novel orphan, C5a receptor (C5L2), during experimental sepsis and sepsis in humansMarkus Huber-Lang
Department of Traumatology, Hand and Reconstructive Surgery, University of Ulm Medical School, Germany
J Immunol 174:1104-10. 2005..In contrast, sepsis survivors exhibited retention of C5L2 (n = 12/13). The data suggest that C5L2 on PMN diminishes during sepsis due to systemic generation of C5a, which is associated with a poor prognosis...
- A protein C deficiency exacerbates inflammatory and hypotensive responses in mice during polymicrobial sepsis in a cecal ligation and puncture modelJorge G Ganopolsky
W M Keck Center for Transgene Research, Department of Chemistry and Biochemistry, 434 Stepan Hall of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556, USA
Am J Pathol 165:1433-46. 2004..Thus, the hemodynamic role of PC during sepsis is of critical importance to the outcome of the disease...
- Evidence for a functional role of the second C5a receptor C5L2Hongwei Gao
Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109 0602, USA
FASEB J 19:1003-5. 2005..When normal blood neutrophils were stimulated in vitro with LPS and C5a, the antibodies had similar effects on release of IL-6. These data provide the first evidence for a role for C5L2 in balancing the biological responses to C5a...
- CCR1 and CC chemokine ligand 5 interactions exacerbate innate immune responses during sepsisTraci L Ness
Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
J Immunol 173:6938-48. 2004..These data illustrate that the interaction between CCR1 and CCL5 modulates the innate immune response during sepsis, and both represent potential targets for therapeutic intervention...
- Case-controlled comparison of a percutaneous collagen arteriotomy closure device versus manual compression after liver chemoembolizationKelvin Hong
Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins Hospital, 600 North Wolfe Street, Blalock 545, Baltimore, Maryland 21287, USA
J Vasc Interv Radiol 16:339-45. 2005....
- The guidewire technique for transseptal punctureSeiichi Haruta
Department of Cardiology, Fukuyama Cardiovascular Hospital, Sumiyoshi cho 1 26, Fukuyama, Hiroshima, Japan
J Invasive Cardiol 17:68-70. 2005
- Opposing and hierarchical roles of leukotrienes in local innate immune versus vascular responses in a model of sepsisClaudia F Benjamim
Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA
J Immunol 174:1616-20. 2005..They also suggest the possible therapeutic utility of targeting vascular events in sepsis with cysteinyl-LT blockade...
- FoxA2 involvement in suppression of protein C, an outcome predictor in experimental sepsisDavid T Berg
Biotechnology Discovery Research, Lilly Corporate Center, Indianapolis, IN 46285, USA
Clin Vaccine Immunol 13:426-32. 2006..Our data suggest that reduced FoxA2 may be important in the suppression of PC and resulting poor outcome in sepsis...
- Failure of neutrophil migration to infectious focus and cardiovascular changes on sepsis in rats: Effects of the inhibition of nitric oxide production, removal of infectious focus, and antimicrobial treatmentD Torres-Dueñas
Department of Pharmacology, School of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Sao Paulo, FMRP USP, Brazil
Shock 25:267-76. 2006..The results showed, for the first time, that the pharmacological prevention of FNM to the infectious focus associated with the antimicrobial therapy could be a new beneficial strategy for the treatment of sepsis syndrome...
- Complications associated with the arterial puncture closure device--Angio-SealAlexander Kadner
Swiss Cardiovascular Center, University Hospital, Freiburgerstrasse, Bern, Switzerland
Vasc Endovascular Surg 42:225-7. 2008..Arterial puncture closure devices (APCD) are frequently used after cardiac catheterization. Here, the diagnosis and therapy of femoral artery complications after the use of the Angio-Seal APCD is reported...
- Beneficial versus detrimental effects of neutrophils are determined by the nature of the insultMario Perl
Shock Trauma Research Laboratories, Division of Surgical Research, Department of Surgery, Rhode Island Hospital and Brown University, School of Medicine, Providence, RI 02903, USA
J Am Coll Surg 204:840-52; discussion 852-3. 2007....
- Effects of ketamine on levels of cytokines, NF-kappaB and TLRs in rat intestine during CLP-induced sepsisMin Yu
Department of Anesthesiology, Jinling Hospital, School of Medicine, Nanjing University, 305 East Zhongshan Road, Nanjing 210002, PR China
Int Immunopharmacol 7:1076-82. 2007..And these anti-inflammatory effects possibly correlate with the inhibitory influence of ketamine on TLR2 and TLR4 expressions...
- Early ambulation after diagnostic heart catheterizationBilal Boztosun
Kosuyolu Heart and Research Centre, Cardiology Department, Istanbul, Turkey
Angiology 58:743-6. 2007..Early mobilization of selected patients undergoing diagnostic heart catheterization through the femoral artery via 6-Fr catheters is safe and associated with acceptable bleeding complication rates...
- Angio-seal in antegrade endovascular interventions: technical success and complications in a 55-patient seriesBaljendra Kapoor
Vascular and Interventional Radiology, The University of Alabama at Birmingham, Birmingham, Alabama 35249, USA
J Endovasc Ther 14:382-6. 2007To assess the technical success and complications of Angio-Seal vascular closure device in antegrade common femoral artery (CFA) punctures.
- Hydrogen sulfide up-regulates substance P in polymicrobial sepsis-associated lung injuryHuili Zhang
Department of Pharmacology, National University of Singapore, Singapore, Singapore
J Immunol 179:4153-60. 2007..The present findings show for the first time that in sepsis, H2S up-regulates the generation of SP, which contributes to lung inflammation and lung injury mainly via activation of the neurokinin-1 receptor...
- The safety and efficacy of an extravascular, water-soluble sealant for vascular closure: initial clinical results for MynxD Scheinert
Department of Angiology, Heart Center, University of Leipzig, Leipzig, Germany
Catheter Cardiovasc Interv 70:627-33. 2007..The purpose of this study was to evaluate the hemostatic efficacy and safety of the Mynx extravascular sealant for femoral artery closure...
- Prospective study of elective bilateral versus unilateral femoral arterial puncture for uterine artery embolizationM J Bratby
Department of Radiology, St George s Hospital, Blackshaw Road, Tooting, London SW17 OQT, UK
Cardiovasc Intervent Radiol 30:1139-43. 2007The purpose of this study was to assess the effect of elective bilateral femoral arterial punctures for uterine artery embolization (UAE) of symptomatic fibroids on fluoroscopy and procedural time, patient dose, and ease of procedure...
- Reducing complications of femoral accessLowell Satler
Division of Cardiology, Washington Hospital Center, Washington, DC 20010, USA
Catheter Cardiovasc Interv 71:524-5. 2008
- Mice depleted of alphabeta but not gammadelta T cells are resistant to mortality caused by cecal ligation and punctureVictor T Enoh
Departments of Anesthesiology, The University of Texas Medical Branch, Galveston, Galveston, Texas 77555 0591, USA
Shock 27:507-19. 2007..The depletion of NK cells caused further survival benefit in alphabeta T cell-deficient mice. These findings suggest that alphabeta T and NK cells mediate or facilitate CLP-induced inflammatory injury...
- Trapping of vascular clip closure device in previously accessed femoral puncture siteSteven J Fowler
Division of Cardiology, The University of California, Irvine Medical Center, Orange, California 92868 4080, USA
Catheter Cardiovasc Interv 70:62-4. 2007
- Acute claudication caused by Angio-Seal closure devices: a report of four casesE Mattens
Department of Surgery, Diaconessenhuis, Meppel, The Netherlands
Acta Chir Belg 108:247-50. 2008..The occurrence of few serious complications can outweigh the relative small benefits these devices offer...
- Signaling via platelet-activating factor receptors accounts for the impairment of neutrophil migration in polymicrobial sepsisSusana E Moreno
Departamento de Farmacologia, Faculdade de Medicina de Ribeirao Preto, Universidade de Sao Paulo, Sao Paulo, Brazil
J Immunol 177:1264-71. 2006..Altogether, the results firmly establish a role for PAFR in mediating the early impairment of neutrophil migration toward the infectious focus. Blockade of PAFR may prevent the establishment of severe sepsis...
- Divergent signaling pathways in phagocytic cells during sepsisRen Feng Guo
Department of Pathology, University of Michigan Medical School, 1301 Catherine Road, Ann Arbor, MI 48109, USA
J Immunol 177:1306-13. 2006..As a result, CXC chemokines increase in lung, setting the stage for neutrophil accumulation in lung during sepsis...
- Closure of the femoral artery after cardiac catheterization: a comparison of Angio-Seal, StarClose, and manual compressionJ H H Deuling
Department of Cardiology, Thorax Center, University Medical Center Groningen, University of Groningen, The Netherlands
Catheter Cardiovasc Interv 71:518-23. 2008..To compare Angio-Seal (AS) and StarClose (SC) and manual compression (MC) on efficacy of hemostasis, complication rate, safety of early mobilization, and patient comfort...
- Initial experience with the Cardiva Boomerang vascular closure device in diagnostic catheterizationBrendan J Doyle
Division of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota 55905, USA
Catheter Cardiovasc Interv 69:203-8. 2007..The authors studied the safety and efficacy of the Cardiva Boomerang vascular closure device in patients undergoing diagnostic cardiac catheterization...
- Hydrogen sulfide acts as an inflammatory mediator in cecal ligation and puncture-induced sepsis in mice by upregulating the production of cytokines and chemokines via NF-kappaBHuili Zhang
Dept of Pharmacology, National University of Singapore, Singapore
Am J Physiol Lung Cell Mol Physiol 292:L960-71. 2007..Therefore, H2S upregulates the production of proinflammatory mediators and exacerbates the systemic inflammation in sepsis through a mechanism involving NF-kappaB activation...
- Moving in the right directionGeorge W Vetrovec
Catheter Cardiovasc Interv 70:634. 2007
- Development of a lethal model of peritonitis for assessment of laparoscopic and laparotomic treatments in ratsWilson Salgado Júnior
Gastroenterology Division, Department of Surgery and Anatomy, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, 14048 900 Ribeirao Preto, SP, Brazil
Acta Cir Bras 22:39-42. 2007..Development of a lethal model of peritonitis to assess the results of treating that peritonitis using videolaparoscopy and laparotomy...
- Blunt atrial transseptal puncture using excimer laser in swineAbdalla A Elagha
Cardiovascular Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA
Catheter Cardiovasc Interv 70:585-90. 2007..We describe a new approach that may enhance safety of atrial transseptal puncture using a commercially available laser catheter that is capable of perforation only when energized. We test this approach in swine...
- Upregulation of cardiovascular ghrelin receptor occurs in the hyperdynamic phase of sepsisRongqian Wu
Division of Surgical Research, Department of Surgery, North Shore University Hospital and Long Island Jewish Medical Center, Manhasset, New York 11030, USA
Am J Physiol Heart Circ Physiol 287:H1296-302. 2004..These results demonstrate that GHSR-1a expression is upregulated and vascular sensitivity to ghrelin stimulation is increased in the hyperdynamic phase of sepsis...
- Impact of the Duett sealing device on quality of life and hospitalization costs for coronary diagnostic and interventional procedures: Results from the Study of Economic and Quality of Life substudy of the SEAL trialZ Zhang
Division of Cardiology, Emory University School of Medicine, Atlanta, GA, USA
Am Heart J 142:982-8. 2001..02). CONCLUSIONS: The Duett sealing device was associated with significantly higher functional status at 7 days after the procedure in addition to shortened time to hemostasis and ambulation, with no associated increase in cost...
- Local vascular complications after use of the hemostatic puncture closure device Angio-SealC Kirchhof
Department of Medicine, Park Krankenhaus Leipzig Südost GmbH, Leipzig, Germany
Vasa 31:101-6. 2002..Here we report about the diagnosis and therapy of femoral artery complications after use of the closure device Angio-Seal, consisting of an intraarterial anchor and extravascular collagen plug...
- Modulation of the phosphoinositide 3-kinase pathway alters innate resistance to polymicrobial sepsisDavid L Williams
Department of Surgery, James H Quillen College of Medicine, East Tennessee State University, PO Box 70575, Johnson City, TN 37614, USA
J Immunol 172:449-56. 2004..This suggests that stimulation of the PI3K pathway may be an effective approach for preventing or treating sepsis and/or septic shock...
- Hemodynamic and cardiac contractile function during sepsis caused by cecal ligation and puncture in miceWeike Tao
Department of Anesthesiology, University of Texas Medical Branch and Shriners Hospital for Children, Galveston, Texas 77555 0591, USA
Shock 21:31-7. 2004..The miniaturized conductance catheter allows for effective measurements of hemodynamic function in septic mice and provides measurements that cannot be obtained using other cardiovascular monitoring techniques...
- A role for CD21/CD35 and CD19 in responses to acute septic peritonitis: a potential mechanism for mast cell activationJ L Gommerman
Department of Pathology, Center for Blood Research and Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
J Immunol 165:6915-21. 2000..Taken together, these findings suggest that the engagement of complement receptors CD21/CD35 along with CD19 on the mast cell surface by C3 fragments may be necessary for the full expression of mast cell activation in the CLP model...
- Restick following initial Angioseal useRobert J Applegate
Section of Cardiology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
Catheter Cardiovasc Interv 58:181-4. 2003..There were no major bleeding, vascular repair, vessel occlusion, or embolizations. Three large hematomas (1.7%) were noted. These data suggest that restick can be performed safely after initial Angioseal deployment...
- Clinical evaluation of SyvekPatch in patients undergoing interventional, EPS and diagnostic cardiac catheterization proceduresR G Nader
Mt Sinai Medical Center and Miami Heart Institute, Miami Beach, FL, USA
J Invasive Cardiol 14:305-7. 2002..A clinical evaluation was designed to determine the efficacy and safety of this vascular closure device in 1,000 consecutive patients after routine diagnostic and interventional procedures...
- Effects of arginine-enriched total parenteral nutrition on inflammatory-related mediator and T-cell population in septic ratsChiu Li Yeh
Institute of Nutrition and Health Science, Taipei Medical University, Taipei, Taiwan, Republic of China
Nutrition 18:631-5. 2002..However, the effects of parenterally infused Arg on sepsis are not well understood. We used a septic rat model to study Arg infusion in inflammatory-related cytokines and blood T lymphocyte population in vivo...
- Anti-IL-10 therapeutic strategy using the immunomodulator AS101 in protecting mice from sepsis-induced death: dependence on timing of immunomodulating interventionYona Kalechman
C A I R Institute, Faculty of Life Sciences, Bar Ilan University, Ramat Gan, Israel
J Immunol 169:384-92. 2002....
- Effect of sodium arsenite on iNOS expression and vascular hyporeactivity associated with cecal ligation and puncture in the ratG J Hauser
Division of Pediatric Critical Care Medicine, Georgetown University Children's Medical Center, Washington, District of Columbia 20007, USA
Shock 15:73-6. 2001....
- Sepsis induces apoptosis and profound depletion of splenic interdigitating and follicular dendritic cellsKevin W Tinsley
Department of Anesthesiology, Washington University School of Medicine, St Louis, MO 63110, USA
J Immunol 171:909-14. 2003..IDC death occurred by caspase 3-mediated apoptosis. Such profound apoptosis induced loss of FDCs and IDCs may significantly compromise B and T cell function and impair the ability of the host to survive sepsis...
- Reduced vascular complications after percutaneous coronary interventions with a nonmechanical suture device: results from the randomized RACE studyTimothy A Sanborn
Evanston Northwestern Healthcare, Evanston, Illinois 60201, USA
Catheter Cardiovasc Interv 61:327-32. 2004..The incidence of major complications after PCI was reduced with the device...
- To plug or not to plug?Joseph Varon
The University of Texas Health Science Center, St Luke s Episcopal Hospital, Houston, Texas, USA
Crit Care 8:87-8. 2004..Further, well designed studies are necessary to document the comparative effects of these devices versus manual compression...
- A new interventional procedure in the treatment of iatrogenic pseudoaneurysmRoberto Marcello
UOC di Radiologia Interventistica e dell Alta Tecnologia, ACO San Filippo Neri, Rome, Italy
Radiol Med 105:63-8. 2003..The purpose of this study was to test the validity and the efficacy of a new interventional procedure in the treatment of iatrogenic pseudoaneurysms...
- Differential expression of cytochrome P450 isoforms in the lungs of septic animalsXiaoxuan Cui
Division of Surgical Research, Department of Surgery, North Shore University Hospital and Long Island Jewish Medical Center, Manhasset, NY 11030, USA
Crit Care Med 32:1186-91. 2004....
- Pathogenic Mechanism for Lung Infection in Mucoid PseudomonasDENNIS EDWARD OHMAN; Fiscal Year: 2013..bacterium can result in nosocomial infections, which is common via respiratory ventilators, catheters, lumbar punctures and general surgery. P...
- Phenotype-Genotype Associations with Symptoms During Childhood Leukemia TreatmentMichael E Scheurer; Fiscal Year: 2013..CSF oxidative stress and cytokine biomarkers will be obtained with all therapeutic lumbar punctures occurring at four time points during post-induction therapy...
- Childhood Leukemia: Oxidative Stress, Cognitive Changes &Academic OutcomesIDA MARIE MOORE; Fiscal Year: 2013..CSF samples will be obtained during diagnostic and therapeutic lumbar punctures for measuring oxidative stress. Aims 1 and 2 will be addressed using mixed model ANOVAs...
- A Nanofibrous Bioactive Hemodialysis Access GraftSAIF G PATHAN; Fiscal Year: 2013..grafts into a canine arteriovenous shunt access model for 30 and 60 days in conjunction with numerous needle punctures and 5) macroscopically and histologically analyze explanted BioAccess and ePTFE grafts...
- Novel antithrombotic agents to prevent hemodialysis vascular access failureTZE CHEIN WUN; Fiscal Year: 2013..Surgical trauma, repeated needle punctures, mechanical shear stress, the foreign graft material and uremia can elicit a strong thrombotic response that ..
- Multi-lumen steerable needles for transoral access to lung nodulesRon Alterovitz; Fiscal Year: 2013..by image-guided steering) and pneumothorax (since, in contrast to transthoracic needle biopsy, our device never punctures the pleura around the lung)...
- Stabilization Device for Transseptal AccessMARK CHRISTIAN SVENDSEN; Fiscal Year: 2013..constant movement of the heart and the thin and slippery nature of the fossa ovalis (FO) make standard TS access punctures unpredictable...
- Neural Correlates of Working Memory Training for HIV PatientsLinda Chang; Fiscal Year: 2013..assess changes in neuroinflammatory markers and monoamine metabolites in the CSF of those who consent to lumbar punctures before and 6 months after training, and evaluate the relationships between these CSF makers, cognitive ..
- The Effects of Rosiglitazone in Patients with MCISuzanne Craft; Fiscal Year: 2009..A subset of participants will receive lumbar punctures before and following treatment to determine whether rosiglitazone affects cerebrospinal fluid (CSF) levels of ..
- RNA Biosignatures in the Emergency Evaluation of Febrile InfantsOctavio Ramilo; Fiscal Year: 2013..a significant and beneficial impact by reducing the number of (1) unnecessary invasive tests (including lumbar punctures), (2) use of empirical antibiotics, (3) hospitalizations and associated iatrogenic complications, and (4) ..
- Linking apparatus dynamics to interbacterial intoxication by type VI secretionPaul A Wiggins; Fiscal Year: 2013..Though the T6SS is often described as a bacteriophage-like pathway that "punctures" recipient cells and injects toxins, a functioning T6S apparatus and the effects it exerts on recipient cells ..
- Resources, Parent-Child Communication and Adjustment to Pediatric CancerLouis A Penner; Fiscal Year: 2013..g., lumbar punctures) are one of the most stressful aspects of pediatric cancer;and thus (c) negative responses to these procedures (..
- BEHAVIORAL INTERVENTION FOR CHILDREN WITH CANCERLonnie Zeltzer; Fiscal Year: 1990..and observer (obs.) ratings and a behavioral checklist during 2 bone marrow aspirations and/or 2 lumbar punctures prior to intervention. Pts...
- NONINVASIVE DEVICE FOR SEALING VASCULAR ACCESS PUNCTURESThomas Anderson; Fiscal Year: 2001....
- Sealing Air Leaks by Inductive Coagulation Following Lung SurgeryKEVIN MARCHITTO; Fiscal Year: 2006..Pilot testing of the device has proven feasibility for sealing dialysis needle perforations, femoral artery punctures, and anastomosing arteries. The non-contact process is safe, easy to use and inexpensive...
- Training Simulator for Epidural Needle InsertionBruce Anderson; Fiscal Year: 2002..Between each vertebra will be a novel actuator and position sensor. When a Touhy needle punctures the artificial skin, it enters a computer controlled haptic feedback, virtual environment...
- Training Simulator for Epidural Needle InsertionJOHN MAGILL; Fiscal Year: 2006..When a Touhy needle punctures the artificial skin, it will encounter, the novel, haptic feedback device, the feasibility of which was ..
- NOVEL PROTECTIVE UNDERGLOVEBakul Bhatt; Fiscal Year: 2004..This technology has been developed to reduce transmission of bacteria and bloodborne pathogens. Glove punctures are frequent, and the potential for pathogen transmission is increasingly significant...
- Parental Role in Pediatric Cancer Pain and SurvivorshipTerrance Albrecht; Fiscal Year: 2005Children with cancer experience stress/trauma during certain treatment-related procedures (e.g.,lumbar punctures, bone marrow aspirations)...
- STABILITY OF INFANT RESPONSES TO PAINFUL PROCEDURESJane Evans; Fiscal Year: 2000..Tissue damage from heel lances, intravenous punctures, and other standard caregiving procedures results in permanent structural changes in the brain and spinal cord ..
- CELLULAR MECHANISMS OF AXONAL REPAIR AND DEGENERATIONHarvey Fishman; Fiscal Year: 2004..vesicles) that we showed are necessary for successful repair (sealing) of axolemmal lesions (transections and punctures) to prevent degeneration of invertebrate giant axons (GAs) or mammalian axons...
- NEUROPSYCHOLOGICAL ASPECTS OF STAGE II/III HIV INFECTIONHUGH HANDSFIELD; Fiscal Year: 1991..of the HIV-infected subjects (30 each with group II and group III HIV infection) will undergo annual lumbar punctures with cerebrospinal fluid culture for HIV and determination of intrathical production of antibody to HIV...
- NONINVASIVE DEVICE FOR SEALING VASCULAR ACCESS PUNCTURESThomas Anderson; Fiscal Year: 2004..abstract_text> ..
- Percutaneous MR Guided Creation of a Meso-Caval ShuntAravind Arepally; Fiscal Year: 2008..aims will support these goals: (1) Develop a novel intravascular needle system to perform MR-guided vena cava punctures; (2) Develop and implement an MRI protocol that will provide complete real-time 3D anatomical definition of ..
- Antiretroviral-Induced Defects in Muscle Protein SynthesisCharles H Lang; Fiscal Year: 2010..Such data is needed to both realize the full potential and avoid possible pitfalls of this drug in the long-term treatment of HIV-infected individuals. ..
- MYOCARDIAL PROTEIN SYNTHESIS AFTER ALCOHOL INTOXICATIONCharles H Lang; Fiscal Year: 2010..Overall, the research design will establish the mechanism by which myocardial protein synthesis is reduced in response to alcohol abuse. ..
- Myocardial Protein Synthesis After Thermal InjuryCharles Lang; Fiscal Year: 2005..Overall, the research will elucidate the mechanisms by which myocardial protein synthesis is reduced after thermal injury, leading to the better understanding and treatment of the resulting cardiomyopathy. - ..
- Novel Methods to Access Brain Function in HIV-1Christina Marra; Fiscal Year: 2003..abstract_text> ..
- ALZHEIMER'S IN LONG TERM PROPRANOLOL FOR AGITATIONElaine Peskind; Fiscal Year: 2003..We will determine if high plasma NE and/or high lymphocyte beta-adrenergic receptor density, affinity, and/or sensitivity define AD patients with disruptive agitation most responsive to propranolol. ..
- ORGAN HEMOSTASIS IN TRAUMA BY HIGH INTENSITY ULTRASOUNDShahram Vaezy; Fiscal Year: 2003..Thus, the investigators believe that their proposed studies will result in a new and clinically applicable methodology for reducing mortality and morbidity in abnormal trauma. ..
- SPINAL BENDING MOTIONS FOR PREVENTING DISC DEGENERATIONAdam Hsieh; Fiscal Year: 2003..These regimens will then be tested experimentally to determine the effects on biosynthesis and apoptosis. ..
- UTERINE TUMOR TREATMENT USING HIGH INTENSITY ULTRASOUNDShahram Vaezy; Fiscal Year: 2003..Ultimately, this treatment approach may also provide an option to preserve fertility and improve reproductive outcomes in patients with fibroid tumors. ..
- ANALYSIS OF ASSOCIATION BETWEEN C. PNEUMONIAE AND MSSubramaniam Sriram; Fiscal Year: 2002..Also, the presence of an immune response to C. pneumoniae that is contained within the CNS compartment will constitute strong circumstantial evidence of microbial infection. ..
- Dietary supplementation with glucan enhances immune fnDavid Williams; Fiscal Year: 2002..At the successful conclusion of this research e will have established what, if any, effect dietary supplementation with glucan has on modulating immunocompetence arid whether oral glucans will increase resistance to infectious diseases. ..
- Pathophysiological Interpretations of Dynamic PET/CT of Molecular Liver BiologySusanne Keiding; Fiscal Year: 2010..This will lead to improved diagnosis and treatment of the large groups of patients with liver disease and cancer in the liver. ..
- Ethical & Methodological Standards for Trials of Invasive Therapeutic ProceduresCarol M Ashton; Fiscal Year: 2010..PUBLIC HEALTH RELEVANCE: The project will result in substantial and much-needed improvements in the methodological and ethical quality of trials performed to evaluate invasive therapeutic procedures in humans. ..
- Anti-ischemic Resuscitation FluidMartin Bluth; Fiscal Year: 2008..abstract_text> ..
- Oxidative Stress Markers and HIV DementiaNed Sacktor; Fiscal Year: 2009..We believe that oxidative stress plays a significant role in the development of HIV-D, and strategies to decrease oxidative stress may serve as a useful therapeutic target to treat HIV-D. ..
- MULTI IMAGER COMPATIBLE ROBOT FOR PROSTATE ACCESSDan Stoianovici; Fiscal Year: 2004..The use of electricity in the imager's room will be eliminated by using optical sensors and pneumatic/hydraulic motors while all control equipment will be located in the control room of the imager. ..
- ROLE OF T PALLIDUM MSP-HOMOLOGUES IN CNS INVASIONChristina Marra; Fiscal Year: 2004..These investigations are most applicable to persons who are also infected with HIV-1, as they are at greatest risk for syphilis and neurosyphilis. ..
- STRETCH-INDUCED CYCLOOXYGENASE-2 IN UROTHELIAL CELLsStephen Nakada; Fiscal Year: 2005..abstract_text> ..
- Novel oral therapeutics for multiple sclerosisSubramaniam Sriram; Fiscal Year: 2006....
- Rapid and Simple CSF Tests for Neurosyphillis DiagnosisChristina Marra; Fiscal Year: 2006..The results of this study will be used to design field trials in the areas of greatest need. ..
- MATH INTERVENTION FOR CHILDREN WITH LEUKEMIAIda Moore; Fiscal Year: 2004..of phospholipids, a biological marker of CNS injury, will be measured in CSF samples collected when lumbar punctures are done for intrathecal therapy...
- ROMK CHANNEL FUNCTION AND REGULATION IN KIDNEYGerhard Giebisch; Fiscal Year: 2003..Patch-clamp and whole-cell current measurements will be carried out in native tubules and in an oocyte expression system, and tubule perfusion studies in ROMK knock-out mice. ..
- Epithelial Na channel (ENaC) polymorphisms in hyptertentionJames Stockand; Fiscal Year: 2007..Preliminary results support the feasibility of this investigation and suggest that this line of inquiry will yield significant and novel findings. [unreadable] [unreadable]..
- Alcohol-specific modifications of glycated Hb: Novel biomarkers of alcohol abuseYousef Al Abed; Fiscal Year: 2007..Future studies will be designed to measure these alcohol-specific-markers in humans following binge and chronic alcohol intake. [unreadable] [unreadable] [unreadable]..
- Imaging of Pulmonary Cancer: Overcoming LimitationsJane Ko; Fiscal Year: 2007..The proposed method will enable early recognition of nodule growth and, therefore, the early diagnosis of malignancy. ..
- Focused Ultrasound for Treatment of NervesShahram Vaezy; Fiscal Year: 2008..It is our goal to develop image- guided focused ultrasound as a non-invasive alternative for the treatment of spasticity and pain. ..
- Biomechanical Engineering of Fibrous Load-Bearing TissueDawn Elliott; Fiscal Year: 2007..Notably, this design approach for load-bearing fiberreinforced tissues, focusing on mechanics first, can be extended to other orthopaedic and cardiovascular tissue applications. ..
- GDF-5 Regulation in Intervertebral Disc DegenerationXudong Li; Fiscal Year: 2008..If successful in achieving meaningful repair, this project will help investigators make significant strides towards enabling disc repair in humans. [unreadable] [unreadable] [unreadable]..
- Stoichiometry and modular retrieval of ENaCJames Stockand; Fiscal Year: 2009..This research will provide critical insight about the molecualr architecture of ENaC and regulation of this important channel. ..
- TENDON FIBER-MATRIX MECHANICS--THEORY AND EXPERIMENTSDawn Elliott; Fiscal Year: 2003..This information will enable us to develop and assess potential treatment modalities. ..