punctures

Summary

Summary: Incision of tissues for injection of medication or for other diagnostic or therapeutic procedures. Punctures of the skin, for example may be used for diagnostic drainage; of blood vessels for diagnostic imaging procedures.

Top Publications

  1. ncbi Cecal ligation and puncture with total parenteral nutrition: a clinically relevant model of the metabolic, hormonal, and inflammatory dysfunction associated with critical illness
    Josef G Heuer
    Biotechnology Discovery Research, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana 46285, USA
    J Surg Res 121:178-86. 2004
  2. ncbi Bleomycin in the treatment of keloids and hypertrophic scars by multiple needle punctures
    A Espana
    Department of Dermatology, University Clinic of Navarra, School of Medicine, University of Navarra, Navarra, Spain
    Dermatol Surg 27:23-7. 2001
  3. ncbi Adoptive transfer of in vitro-stimulated CD4+CD25+ regulatory T cells increases bacterial clearance and improves survival in polymicrobial sepsis
    Josef G Heuer
    Biotechnology Discovery Research, Lilly Corporate Center, Indianapolis, IN 46285, USA
    J Immunol 174:7141-6. 2005
  4. ncbi Cecal ligation and puncture as a model of sepsis in the rat: influence of the puncture size on mortality, bacteremia, endotoxemia and tumor necrosis factor alpha levels
    E Otero-Anton
    Department of Medicine, Complejo Hospitalario Universitario, Santiago de Compostela, Spain
    Eur Surg Res 33:77-9. 2001
  5. ncbi Increased sarcolemmal permeability as an early event in experimental septic cardiomyopathy: a potential role for oxidative damage to lipids and proteins
    Mara R N Celes
    Department of Pathology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Sao Paulo, Brazil
    Shock 33:322-31. 2010
  6. ncbi Complement-induced impairment of innate immunity during sepsis
    Markus S Huber-Lang
    Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J Immunol 169:3223-31. 2002
  7. ncbi Arterial puncture closing devices compared with standard manual compression after cardiac catheterization: systematic review and meta-analysis
    Maria Koreny
    Department of Emergency Medicine, University of Vienna, Vienna General Hospital, Vienna, Austria
    JAMA 291:350-7. 2004
  8. ncbi Interatrial septum thickness and difficulty with transseptal puncture during redo catheter ablation of atrial fibrillation
    David R Tomlinson
    Department of Cardiac Rhythm Management, John Radcliffe Hospital, Oxford, United Kingdom
    Pacing Clin Electrophysiol 31:1606-11. 2008
  9. ncbi Multicenter evaluation of a new laser guidance system for computed tomography intervention
    K Brabrand
    Department of Radiology, Rikshospitalet University Hospital, Oslo, Norway
    Acta Radiol 45:308-12. 2004
  10. ncbi Percutaneous punctures with MR imaging guidance: comparison between MR imaging-enhanced fluoroscopic guidance and real-time MR Imaging guidance
    Bernhard Christian Meyer
    Department of Radiology, Hannover Medical School, Carl Neuberg Str 1, 30625 Hannover, Germany
    Radiology 266:912-9. 2013

Detail Information

Publications231 found, 100 shown here

  1. ncbi Cecal ligation and puncture with total parenteral nutrition: a clinically relevant model of the metabolic, hormonal, and inflammatory dysfunction associated with critical illness
    Josef G Heuer
    Biotechnology Discovery Research, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana 46285, USA
    J Surg Res 121:178-86. 2004
    ..Accordingly, we sought to develop a model of rat CLP with prolonged hyperglycemia through continuous infusion of total parenteral nutrition (TPN) post CLP...
  2. ncbi Bleomycin in the treatment of keloids and hypertrophic scars by multiple needle punctures
    A Espana
    Department of Dermatology, University Clinic of Navarra, School of Medicine, University of Navarra, Navarra, Spain
    Dermatol Surg 27:23-7. 2001
    ..The treatment of keloids and hypertrophic scars has been difficult and a recent French study showed that bleomycin has been useful in the treatment of these lesions...
  3. ncbi Adoptive transfer of in vitro-stimulated CD4+CD25+ regulatory T cells increases bacterial clearance and improves survival in polymicrobial sepsis
    Josef G Heuer
    Biotechnology Discovery Research, Lilly Corporate Center, Indianapolis, IN 46285, USA
    J Immunol 174:7141-6. 2005
    ..More importantly, adoptive transfer of in vitro-stimulated Tregs significantly improved bacterial clearance, which resulted in improved survival. Our results suggest a novel role for Tregs in sepsis...
  4. ncbi Cecal ligation and puncture as a model of sepsis in the rat: influence of the puncture size on mortality, bacteremia, endotoxemia and tumor necrosis factor alpha levels
    E Otero-Anton
    Department of Medicine, Complejo Hospitalario Universitario, Santiago de Compostela, Spain
    Eur Surg Res 33:77-9. 2001
    ..Cecal ligation and puncture is a widely used experimental model of sepsis...
  5. ncbi Increased sarcolemmal permeability as an early event in experimental septic cardiomyopathy: a potential role for oxidative damage to lipids and proteins
    Mara R N Celes
    Department of Pathology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Sao Paulo, Brazil
    Shock 33:322-31. 2010
    ....
  6. ncbi Complement-induced impairment of innate immunity during sepsis
    Markus S Huber-Lang
    Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J Immunol 169:3223-31. 2002
    ..These data identify a molecular basis for defective innate immunity involving neutrophils during sepsis...
  7. ncbi Arterial puncture closing devices compared with standard manual compression after cardiac catheterization: systematic review and meta-analysis
    Maria Koreny
    Department of Emergency Medicine, University of Vienna, Vienna General Hospital, Vienna, Austria
    JAMA 291:350-7. 2004
    ..Arterial puncture closing devices (APCDs) were developed to replace standard compression at the puncture site and to shorten bed rest following percutaneous coronary intervention...
  8. ncbi Interatrial septum thickness and difficulty with transseptal puncture during redo catheter ablation of atrial fibrillation
    David R Tomlinson
    Department of Cardiac Rhythm Management, John Radcliffe Hospital, Oxford, United Kingdom
    Pacing Clin Electrophysiol 31:1606-11. 2008
    ..Patients undergoing catheter ablation for atrial fibrillation (AF) frequently require redo procedures, but there are no data reporting interatrial septum thickness (IAS) and difficulty during repeat transseptal puncture (TSP)...
  9. ncbi Multicenter evaluation of a new laser guidance system for computed tomography intervention
    K Brabrand
    Department of Radiology, Rikshospitalet University Hospital, Oslo, Norway
    Acta Radiol 45:308-12. 2004
    To measure the accuracy of laser-guided punctures and to evaluate the usefulness of the developed laser-guided system.
  10. ncbi Percutaneous punctures with MR imaging guidance: comparison between MR imaging-enhanced fluoroscopic guidance and real-time MR Imaging guidance
    Bernhard Christian Meyer
    Department of Radiology, Hannover Medical School, Carl Neuberg Str 1, 30625 Hannover, Germany
    Radiology 266:912-9. 2013
    ..To evaluate and compare the technical accuracy and feasibility of magnetic resonance (MR) imaging-enhanced fluoroscopic guidance and real-time MR imaging guidance for percutaneous puncture procedures in phantoms and animals...
  11. ncbi Use of local anesthesia for arterial punctures
    Timothy L Hudson
    US Army, Fort Bragg, NC 28307, USA
    Am J Crit Care 15:595-9. 2006
    ..Arterial puncture is a source of pain and discomfort. Intradermal injection of lidocaine around the puncture site decreases the incidence and severity of localized pain when used before arterial puncture...
  12. ncbi A conservative approach to performing transseptal punctures without the use of intracardiac echocardiography: stepwise approach with real-time video clips
    Alan Cheng
    Department of Medicine, Division of Cardiology, Section for Cardiac Electrophysiology, The Johns Hopkins Hospital, Baltimore, Maryland, USA
    J Cardiovasc Electrophysiol 18:686-9. 2007
    ..The aim of this brief report is to describe in detail our technique for performing transseptal punctures during catheter ablation procedures for atrial fibrillation...
  13. ncbi Altered neutrophil trafficking during sepsis
    Ren Feng Guo
    Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109 0602, USA
    J Immunol 169:307-14. 2002
    ..These data suggest that sepsis causes enhanced neutrophil trafficking into the lung via mechanisms that are not engaged in the nonseptic state...
  14. ncbi Ultrasonography-guided punctures-with and without puncture guide
    Mahesh Desai
    Department of Urology, Muljibhai Patel Urological Hospital, Gujarat, India
    J Endourol 23:1641-3. 2009
    ..We think the punctures with this technique are suboptimal. Both methods need a certain degree of training and orientation...
  15. ncbi Radiofrequency puncture of the fossa ovalis for resistant transseptal access
    Sebastien Knecht
    Hôpital Cardiologique du Haut Lévêque and the Université Victor Segalen Bordeaux II, Bordeaux, France
    Circ Arrhythm Electrophysiol 1:169-74. 2008
    ..We evaluated the efficacy and safety of a new method to cross-resistant septae by transmitting radiofrequency (RF) energy through the transseptal needle...
  16. ncbi Cryptococcal meningitis management in Tanzania with strict schedule of serial lumber punctures using intravenous tubing sets: an operational research study
    John Meda
    Department of Internal Medicine, Dodoma University, Dodoma, Tanzania Department of Internal Medicine, Bugando Medical Centre, Mwanza, Tanzania Department of Internal Medicine, Weill Bugando School of Medicine, Mwanza, Tanzania Department of Medicine, Center for Global Health, Weill Cornell Medical College, New York, NY Department of Internal Medicine, Muhimbili National Hospital, Dar es Salaam, Tanzania and Departments of Microbiology Biochemistry, Catholic University of Health and Allied Sciences Bugando, Mwanza, Tanzania
    J Acquir Immune Defic Syndr 66:e31-6. 2014
    ..Controlling intracranial pressure (ICP) is essential in CM, but it is difficult in low-income countries because manometers and practical ICP management protocols are lacking...
  17. ncbi Incidence of tissue coring during transseptal catheterization when using electrocautery and a standard transseptal needle
    Eugene Greenstein
    Division of Cardiology, Department of Internal Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Circ Arrhythm Electrophysiol 5:341-4. 2012
    ..The purpose of this study was to determine the incidence of cardiac tissue coring when this technique is used...
  18. ncbi The use of a novel nitinol guidewire to facilitate transseptal puncture and left atrial catheterization for catheter ablation procedures
    Vineet Wadehra
    The Heart Hospital, University College London Hospitals NHS Foundation Trust, 16 18 Westmoreland Street, London W1G 8PH, UK
    Europace 13:1401-5. 2011
    An increasing number of transseptal punctures (TSPs) are performed worldwide for atrial ablations. Transseptal punctures can be complex and can be associated with potentially life threatening complications...
  19. ncbi Transcatheter creation of atrial septal perforation using a radiofrequency transseptal system: novel approach as an alternative to transseptal needle puncture
    Yoshihito Sakata
    Evanston Northwestern Healthcare, Evanston, IL 60201, USA
    Catheter Cardiovasc Interv 64:327-32. 2005
    ..We applied this technique to a series of patients and evaluated its feasibility as an alternative to conventional transseptal needle puncture...
  20. ncbi Evaluation of voice prosthesis placement at the time of primary tracheoesophageal puncture with total laryngectomy
    Daniel G Deschler
    Massachusetts Eye and Ear Infirmary, Division of Head and Neck Surgery, Department of Otology and Laryngology, Harvard Medical School, Boston 02114, Massachusetts, USA
    Laryngoscope 119:1353-7. 2009
    ....
  21. ncbi Simplified technique of tracheoesophageal prosthesis placement at the time of secondary tracheoesophageal puncture (TEP)
    Daniel G Deschler
    Massachusetts Eye and Ear Infirmary, Division of Head and Neck Surgery, Department of Otology and Laryngology, Harvard Medical School, Boston, Massachusetts, USA
    Laryngoscope 121:1855-9. 2011
    ..We describe the technique and evaluate the success and potential advantages...
  22. ncbi Efficient reduction of stimulus artefact in TMS-EEG by epithelial short-circuiting by mini-punctures
    P Julkunen
    Department of Clinical Neurophysiology, Kuopio University Hospital, P O Box 1777, FI 70211 Kuopio, Finland
    Clin Neurophysiol 119:475-81. 2008
    ..We aimed at comparing the effects of two different electrode-to-skin contact preparation techniques on the stimulus artefact induced by transcranial magnetic stimulation (TMS) in electroencephalography (EEG) signals...
  23. ncbi Repeat transseptal catheterization after ablation for atrial fibrillation
    Gregory M Marcus
    Division of Cardiology, Electrophysiology Section, University of California, San Francisco, California 94143 1354, USA
    J Cardiovasc Electrophysiol 18:55-9. 2007
    ..The aim of this study was to determine the difficulty and/or success rates of repeat transseptal catheterization after left atrial ablation for AF...
  24. ncbi Repetitive low-volume blood sampling method as a feasible monitoring tool in a mouse model of sepsis
    Katrin M Weixelbaumer
    Ludwig Boltzmann Institute for Experimental and Clinical Traumatology in the Trauma Research Center of AUVA, Vienna, Austria
    Shock 34:420-6. 2010
    ..9; slope, ≥0.9), except lymphocytes (r > 0.5; slope, >0.5). This method provides a feasible and safe translation of clinically relevant daily immunomonitoring to the mouse sepsis model...
  25. ncbi Relationship between cytokine mRNA expression and organ damage following cecal ligation and puncture
    Rong Qian Wu
    Institute of Surgical Research, General Hospital of PLA, Beijing 100853, China
    World J Gastroenterol 8:131-4. 2002
    ..To investigate the role of cytokine gene expression in organ damage at different tissue sites during sepsis...
  26. pmc Methyl-2-acetamidoacrylate, an ethyl pyruvate analog, decreases sepsis-induced acute kidney injury in mice
    Asada Leelahavanichkul
    NIH NIDDK, Bldg 10, Rm 3N108, 10 Center Drive, MSC 1268, Bethesda, MD 20892 1268, USA
    Am J Physiol Renal Physiol 295:F1825-35. 2008
    ..Identifying this new target and downstream signaling pathways could lengthen the therapeutic window and improve combination therapy with chloroquine...
  27. ncbi Complications of laparoscopic surgery: How to avoid them and how to repair them
    Gerald J Shirk
    Department of Obstetrics and Gynecology, Roy and Lucille Carver Medical School, University of Iowa, Iowa City, Iowa, USA
    J Minim Invasive Gynecol 13:352-9; quiz 360-1. 2006
  28. ncbi Predictors of complications and learning curve using the Angio-Seal closure device following interventional and diagnostic catheterization
    B S Warren
    Department of Chemistry, Carleton College, Northfield, Minnesota, USA
    Catheter Cardiovasc Interv 48:162-6. 1999
    ..009) and failure to deploy was independent of sheath size used. Angio-Seal can be used with reasonable safety and efficacy immediately after diagnostic and interventional procedures. Cathet. Cardiovasc. Intervent. 48:162-166, 1999...
  29. ncbi Use of a collagen-based device for closure of low brachial artery punctures
    A Belenky
    Department of Interventional Radiology, Rabin Medical Center, Beilinson and Glolda Campuses, Petah Tiqwa, Sakler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Cardiovasc Intervent Radiol 30:273-5. 2007
    ..To report our experience with the Angioseal vascular closure device for hemostasis of distal brachial artery puncture...
  30. ncbi Development of a new support method for transpedicular punctures of the vertebral body: the isocenter puncture method
    Kenji Takizawa
    Department of Radiology, St Marianna University School of Medicine, Sugao, Miyamae, Kawasaki, Kanagawa, Japan
    Cardiovasc Intervent Radiol 30:757-60. 2007
  31. ncbi Effects of a membrane-permeable radical scavenger, Tempol, on healing of colonic anastomoses in the cecal ligation and puncture model of polymicrobial sepsis in rats
    Faruk Onder Aytekin
    Faculty of Medicine, Department of General Surgery, Pamukkale University, 20070 Kinikli, Denizli, Turkey
    Am J Surg 193:723-9. 2007
    ..In this study we aimed to investigate the effects of Tempol on the healing of colonic anastomoses in the presence of polymicrobial sepsis...
  32. ncbi Recorded maternal voice for preterm neonates undergoing heel lance
    C Celeste Johnston
    McGill University Health Center, Montreal, Quebec, Canada
    Adv Neonatal Care 7:258-66. 2007
    ..To determine if a recording of a mother's voice talking soothingly to her baby is useful in diminishing pain in newborns born between 32 and 36 weeks' gestational age (GA) during routine painful procedures...
  33. ncbi The efficacy of non-pharmacological interventions in the management of procedural pain in preterm and term neonates. A systematic literature review
    Eva Cignacco
    Department for Obstetrics and Neonatology, Women s and Children s Clinic, University Hospital Insel, Bern, Effingerstr 102, CH 3010 Bern, Switzerland
    Eur J Pain 11:139-52. 2007
    ..Non-pharmacological treatment methods are being increasingly discussed with regard to pain prevention and relief either alone or in combination with pharmacological treatment...
  34. ncbi Anterior stromal puncture for recurrent corneal erosion after laser in situ keratomileusis
    Monika A Malecha
    Department of Ophthalmology, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    J Cataract Refract Surg 30:496-8. 2004
    ..The secondary DLK resolved quickly after the erosion healed, without the need for topical corticosteroids. Anterior stromal puncture may be a useful treatment for recurrent corneal erosions that do not respond to conventional therapy...
  35. ncbi In vivo observation of mesenteric leukocyte-endothelial interactions after cecal ligation/puncture and surgical sepsis source control
    Naomi K Nakagawa
    Research Division, Heart Institute, InCor, University of Sao Paulo School of Medicine, Sao Paulo, SP, Brazil
    Clinics (Sao Paulo) 62:321-6. 2007
    ..The aim of this study was to evaluate leukocyte-endothelial interactions in the rat mesentery in vivo after CLP and REL...
  36. ncbi Breastfeeding or breast milk for procedural pain in neonates
    P S Shah
    University of Toronto, Department of Paediatrics and Department of Health Policy, Management and Evaluation, Rm 775A, 600 University Avenue, Toronto, Ontario, Canada M5G 1XB
    Cochrane Database Syst Rev 3:CD004950. 2006
    ..Nonpharmacological measures (such as holding, swaddling, breastfeeding) and pharmacological measures (such as acetaminophen, sucrose and opioids) have been used for this purpose...
  37. ncbi Breastfeeding is analgesic in healthy newborns
    Larry Gray
    Section of Behavioral and Developmental Pediatrics, University of Chicago, Comers Children s Hospital, Chicago, Illinois 60637 1470, USA
    Pediatrics 109:590-3. 2002
    ..This study identifies a behavioral and nonpharmacologic means of preventing newborn pain...
  38. ncbi Enhanced kangaroo mother care for heel lance in preterm neonates: a crossover trial
    C C Johnston
    School of Nursing, McGill University, Montreal, QC, Canada
    J Perinatol 29:51-6. 2009
    ..To test if enhancing maternal skin-to-skin contact, or kangaroo mother care (KMC) by adding rocking, singing and sucking is more efficacious than simple KMC for procedural pain in preterm neonates...
  39. ncbi Bacteriology and antimicrobial susceptibility of pediatric chronic rhinosinusitis: a 6-year result of maxillary sinus punctures
    Chung Han Hsin
    Department of Otolaryngology, Chung Shan Medical University Hospital and School of Medicine, Taichung, Taiwan
    Am J Otolaryngol 31:145-9. 2010
    ..This study aimed to characterize organisms cultured from pediatric chronic rhinosinusitis, as well as current resistance patterns of pathogens...
  40. ncbi Treatment of type II endoleaks after endovascular repair of abdominal aortic aneurysms: translumbar puncture and injection of thrombin into the aneurysm sac
    R Rial
    Department of Vascular Surgery, Hospital Clinico San Carlos, Universidad Complutense, Madrid, Spain
    Eur J Vasc Endovasc Surg 27:333-5. 2004
    ..The aim of this article is to report our experience in the use of a new technique for the treatment of type II endoleaks which appear after the endovascular treatment of abdominal aortic aneurysms...
  41. ncbi Management of pain from heel lance with lidocaine-prilocaine (EMLA) cream: is it safe and efficacious in preterm infants?
    B Stevens
    Faculties of Nursing and Medicine, University of Toronto, Department of Pediatrics, The Hospital for Sick Children, Ontario, Canada
    J Dev Behav Pediatr 20:216-21. 1999
    ..The authors conclude that EMLA is safe but not efficacious for relieving pain from heel lance in preterm infants...
  42. ncbi Laparoscopic ovarian drilling in the treatment of polycystic ovary syndrome: how many punctures per ovary are needed to improve the reproductive outcome?
    Hasan Y Malkawi
    King Hussein Medical Center, Department of Obstetrics and Gynecology, Infertility Clinic, Amman, Jordan
    J Obstet Gynaecol Res 31:115-9. 2005
    To evaluate the biochemical, clinical and reproductive results after laparoscopic ovarian drilling that carried out a different number of punctures in the ovaries.
  43. ncbi Femoral artery stenosis following percutaneous closure using a starclose closure device
    Clare Louise Bent
    Department of Diagnostic Imaging, Barts and The London NHS Trust, Whitechapel, London, E1 1BB, UK
    Cardiovasc Intervent Radiol 31:814-6. 2008
    ..A Starclose femoral artery closure device was used to achieve hemostasis with subsequent femoral artery stenosis...
  44. ncbi Comparison of arterial closure devices in antegrade and retrograde punctures
    Albert Ho Yuen Chiu
    Department of Radiology, Sir Charles Gairdner Hospital, Perth, Australia
    J Endovasc Ther 15:315-21. 2008
    To compare the efficacy, primary failure rates, and complications for the Angio-Seal and Perclose closure devices in antegrade and retrograde common femoral artery (CFA) punctures during peripheral angioplasty procedures.
  45. ncbi Infectious complications related to the use of the angio-seal hemostatic puncture closure device
    C L Cooper
    Department of Internal Medicine, Section of Infectious Diseases, University of Manitoba, Winnipeg, Manitoba, Canada
    Catheter Cardiovasc Interv 48:301-3. 1999
    ....
  46. ncbi Initial experience using a radiofrequency powered transseptal needle
    Matthew P Smelley
    Section of Cardiology, Department of Internal Medicine, University of Chicago, Chicago, Illinois, USA
    J Cardiovasc Electrophysiol 21:423-7. 2010
    ..The purpose of this study was to determine the safety and efficacy of using a novel radiofrequency (RF) powered transseptal needle to perform transseptal puncture (TSP)...
  47. ncbi Do iatrogenic punctures of the labrum affect the clinical results of hip arthroscopy?
    John S Badylak
    Division of Sports Medicine, Department of Orthopaedics and Rehabilitation, University of Wisconsin, Madison, WI 53792 7375, USA
    Arthroscopy 27:761-7. 2011
    To document the effect of iatrogenic labral punctures (ILPs) on the clinical results of hip arthroscopy.
  48. ncbi Patient tolerance and resource utilization associated with an arterial closure versus an external compression device after percutaneous coronary intervention
    Craig P Juergens
    Department of Cardiology, Liverpool Hospital, Liverpool, New South Wales, Australia
    Catheter Cardiovasc Interv 63:166-70. 2004
    ..However, patients receiving the AngioSeal were able to ambulate sooner and reported less pain, which may justify the increased costs involved...
  49. ncbi Vascular complications after percutaneous coronary interventions following hemostasis with manual compression versus arteriotomy closure devices
    G Dangas
    Cardiovascular Research Foundation, Lenox Hill Heart and Vascular Institute, New York, New York, USA
    J Am Coll Cardiol 38:638-41. 2001
    ..5 vs. 1.5%, p = 0.03). CONCLUSIONS: In this early experience with ACD after PCI, their use was associated with higher vascular complication rates than hemostasis with manual compression...
  50. ncbi Use of FemoStop system for arterial puncture site closure after coronary angioplasty
    M Kunert
    Department of Cardiology, Marienhospital Bottrop, Germany
    J Invasive Cardiol 16:240-2. 2004
    ..5% versus 3.1%; p<0.05). In the clinical setting of intensive heparin anticoagulation and early sheath removal after PTCA (<8 hours), the FemoStop system cannot be recommended due to prolonged femoral artery compression times...
  51. ncbi Glove punctures and postoperative skin flora of hands in cardiac surgery
    Anne M Eklund
    Department of Cardiothoracic Surgery, Helsinki University Central Hospital, Finland
    Ann Thorac Surg 74:149-53. 2002
    ..Surgical gloves are frequently perforated during operations, including heart operations. This infection risk factor is inadequately studied...
  52. ncbi Caecal ligation and puncture in the rat mimics the pathophysiological changes in human sepsis and causes multi-organ dysfunction
    H F Brooks
    Division of Basic Medical Sciences and Image Resource Facility, St George s University of London, Cranmer Terrace, Tooting, London, UK
    Metab Brain Dis 22:353-73. 2007
    ..It appears to be the best available animal model currently available, in which to investigate the underlying pathophysiology of sepsis and identify therapeutic targets...
  53. pmc Kangaroo mother care diminishes pain from heel lance in very preterm neonates: a crossover trial
    C Celeste Johnston
    School of Nursing, McGill University, Montreal, Canada
    BMC Pediatr 8:13. 2008
    ..The purpose of this study was to determine if KMC would also be efficacious in very preterm neonates...
  54. pmc Peroxynitrite mediates the failure of neutrophil migration in severe polymicrobial sepsis in mice
    D Torres-Dueñas
    Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Avenida Bandeirantes, 3900, Ribeirao Preto, Sao Paulo, Brazil
    Br J Pharmacol 152:341-52. 2007
    ..The present study addresses the possibility that peroxynitrite (ONOO(-)), a NO-derived powerful oxidizing and nitrating compound, could also be involved in neutrophil migration failure...
  55. ncbi Early mobilization after percutaneous catheterization and vascular closure with a novel device (Star-Close)
    Alessandro Desideri
    Cardiovascular Research Foundation, S Giacomo Hospital, Castelfranco Veneto, Italy
    Am J Cardiol 96:1408-9. 2005
    ..Unsuccessful device deployment occurred in 5 patients. We conclude that Star-Close is a novel arteriotomy closure device that, in selected patients, is safe and allows early deambulation after diagnostic cardiac catheterization...
  56. ncbi Sophorolipids block lethal effects of septic shock in rats in a cecal ligation and puncture model of experimental sepsis
    Martin H Bluth
    SUNY Downstate Medical Center, Department of Surgery, Brooklyn, NY 11203, USA
    Crit Care Med 34:188-95. 2006
    ..The potential of the therapeutic effect of sophorolipids was investigated in vivo in a rat model of sepsis and in vitro by analysis of nitric oxide and cytokine production...
  57. ncbi Changes in the novel orphan, C5a receptor (C5L2), during experimental sepsis and sepsis in humans
    Markus Huber-Lang
    Department of Traumatology, Hand and Reconstructive Surgery, University of Ulm Medical School, Germany
    J Immunol 174:1104-10. 2005
    ..In contrast, sepsis survivors exhibited retention of C5L2 (n = 12/13). The data suggest that C5L2 on PMN diminishes during sepsis due to systemic generation of C5a, which is associated with a poor prognosis...
  58. pmc A protein C deficiency exacerbates inflammatory and hypotensive responses in mice during polymicrobial sepsis in a cecal ligation and puncture model
    Jorge G Ganopolsky
    W M Keck Center for Transgene Research, Department of Chemistry and Biochemistry, 434 Stepan Hall of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556, USA
    Am J Pathol 165:1433-46. 2004
    ..Thus, the hemodynamic role of PC during sepsis is of critical importance to the outcome of the disease...
  59. ncbi Evidence for a functional role of the second C5a receptor C5L2
    Hongwei Gao
    Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109 0602, USA
    FASEB J 19:1003-5. 2005
    ..When normal blood neutrophils were stimulated in vitro with LPS and C5a, the antibodies had similar effects on release of IL-6. These data provide the first evidence for a role for C5L2 in balancing the biological responses to C5a...
  60. ncbi CCR1 and CC chemokine ligand 5 interactions exacerbate innate immune responses during sepsis
    Traci L Ness
    Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J Immunol 173:6938-48. 2004
    ..These data illustrate that the interaction between CCR1 and CCL5 modulates the innate immune response during sepsis, and both represent potential targets for therapeutic intervention...
  61. ncbi Case-controlled comparison of a percutaneous collagen arteriotomy closure device versus manual compression after liver chemoembolization
    Kelvin Hong
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins Hospital, 600 North Wolfe Street, Blalock 545, Baltimore, Maryland 21287, USA
    J Vasc Interv Radiol 16:339-45. 2005
    ....
  62. ncbi The guidewire technique for transseptal puncture
    Seiichi Haruta
    Department of Cardiology, Fukuyama Cardiovascular Hospital, Sumiyoshi cho 1 26, Fukuyama, Hiroshima, Japan
    J Invasive Cardiol 17:68-70. 2005
  63. ncbi Opposing and hierarchical roles of leukotrienes in local innate immune versus vascular responses in a model of sepsis
    Claudia F Benjamim
    Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA
    J Immunol 174:1616-20. 2005
    ..They also suggest the possible therapeutic utility of targeting vascular events in sepsis with cysteinyl-LT blockade...
  64. pmc FoxA2 involvement in suppression of protein C, an outcome predictor in experimental sepsis
    David T Berg
    Biotechnology Discovery Research, Lilly Corporate Center, Indianapolis, IN 46285, USA
    Clin Vaccine Immunol 13:426-32. 2006
    ..Our data suggest that reduced FoxA2 may be important in the suppression of PC and resulting poor outcome in sepsis...
  65. ncbi Failure of neutrophil migration to infectious focus and cardiovascular changes on sepsis in rats: Effects of the inhibition of nitric oxide production, removal of infectious focus, and antimicrobial treatment
    D Torres-Dueñas
    Department of Pharmacology, School of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Sao Paulo, FMRP USP, Brazil
    Shock 25:267-76. 2006
    ..The results showed, for the first time, that the pharmacological prevention of FNM to the infectious focus associated with the antimicrobial therapy could be a new beneficial strategy for the treatment of sepsis syndrome...
  66. ncbi Complications associated with the arterial puncture closure device--Angio-Seal
    Alexander Kadner
    Swiss Cardiovascular Center, University Hospital, Freiburgerstrasse, Bern, Switzerland
    Vasc Endovascular Surg 42:225-7. 2008
    ..Arterial puncture closure devices (APCD) are frequently used after cardiac catheterization. Here, the diagnosis and therapy of femoral artery complications after the use of the Angio-Seal APCD is reported...
  67. ncbi Beneficial versus detrimental effects of neutrophils are determined by the nature of the insult
    Mario Perl
    Shock Trauma Research Laboratories, Division of Surgical Research, Department of Surgery, Rhode Island Hospital and Brown University, School of Medicine, Providence, RI 02903, USA
    J Am Coll Surg 204:840-52; discussion 852-3. 2007
    ....
  68. ncbi Effects of ketamine on levels of cytokines, NF-kappaB and TLRs in rat intestine during CLP-induced sepsis
    Min Yu
    Department of Anesthesiology, Jinling Hospital, School of Medicine, Nanjing University, 305 East Zhongshan Road, Nanjing 210002, PR China
    Int Immunopharmacol 7:1076-82. 2007
    ..And these anti-inflammatory effects possibly correlate with the inhibitory influence of ketamine on TLR2 and TLR4 expressions...
  69. ncbi Early ambulation after diagnostic heart catheterization
    Bilal Boztosun
    Kosuyolu Heart and Research Centre, Cardiology Department, Istanbul, Turkey
    Angiology 58:743-6. 2007
    ..Early mobilization of selected patients undergoing diagnostic heart catheterization through the femoral artery via 6-Fr catheters is safe and associated with acceptable bleeding complication rates...
  70. ncbi Angio-seal in antegrade endovascular interventions: technical success and complications in a 55-patient series
    Baljendra Kapoor
    Vascular and Interventional Radiology, The University of Alabama at Birmingham, Birmingham, Alabama 35249, USA
    J Endovasc Ther 14:382-6. 2007
    To assess the technical success and complications of Angio-Seal vascular closure device in antegrade common femoral artery (CFA) punctures.
  71. ncbi Hydrogen sulfide up-regulates substance P in polymicrobial sepsis-associated lung injury
    Huili Zhang
    Department of Pharmacology, National University of Singapore, Singapore, Singapore
    J Immunol 179:4153-60. 2007
    ..The present findings show for the first time that in sepsis, H2S up-regulates the generation of SP, which contributes to lung inflammation and lung injury mainly via activation of the neurokinin-1 receptor...
  72. ncbi The safety and efficacy of an extravascular, water-soluble sealant for vascular closure: initial clinical results for Mynx
    D Scheinert
    Department of Angiology, Heart Center, University of Leipzig, Leipzig, Germany
    Catheter Cardiovasc Interv 70:627-33. 2007
    ..The purpose of this study was to evaluate the hemostatic efficacy and safety of the Mynx extravascular sealant for femoral artery closure...
  73. ncbi Prospective study of elective bilateral versus unilateral femoral arterial puncture for uterine artery embolization
    M J Bratby
    Department of Radiology, St George s Hospital, Blackshaw Road, Tooting, London SW17 OQT, UK
    Cardiovasc Intervent Radiol 30:1139-43. 2007
    The purpose of this study was to assess the effect of elective bilateral femoral arterial punctures for uterine artery embolization (UAE) of symptomatic fibroids on fluoroscopy and procedural time, patient dose, and ease of procedure...
  74. doi Reducing complications of femoral access
    Lowell Satler
    Division of Cardiology, Washington Hospital Center, Washington, DC 20010, USA
    Catheter Cardiovasc Interv 71:524-5. 2008
  75. ncbi Mice depleted of alphabeta but not gammadelta T cells are resistant to mortality caused by cecal ligation and puncture
    Victor T Enoh
    Departments of Anesthesiology, The University of Texas Medical Branch, Galveston, Galveston, Texas 77555 0591, USA
    Shock 27:507-19. 2007
    ..The depletion of NK cells caused further survival benefit in alphabeta T cell-deficient mice. These findings suggest that alphabeta T and NK cells mediate or facilitate CLP-induced inflammatory injury...
  76. ncbi Trapping of vascular clip closure device in previously accessed femoral puncture site
    Steven J Fowler
    Division of Cardiology, The University of California, Irvine Medical Center, Orange, California 92868 4080, USA
    Catheter Cardiovasc Interv 70:62-4. 2007
  77. ncbi Acute claudication caused by Angio-Seal closure devices: a report of four cases
    E Mattens
    Department of Surgery, Diaconessenhuis, Meppel, The Netherlands
    Acta Chir Belg 108:247-50. 2008
    ..The occurrence of few serious complications can outweigh the relative small benefits these devices offer...
  78. ncbi Signaling via platelet-activating factor receptors accounts for the impairment of neutrophil migration in polymicrobial sepsis
    Susana E Moreno
    Departamento de Farmacologia, Faculdade de Medicina de Ribeirao Preto, Universidade de Sao Paulo, Sao Paulo, Brazil
    J Immunol 177:1264-71. 2006
    ..Altogether, the results firmly establish a role for PAFR in mediating the early impairment of neutrophil migration toward the infectious focus. Blockade of PAFR may prevent the establishment of severe sepsis...
  79. ncbi Divergent signaling pathways in phagocytic cells during sepsis
    Ren Feng Guo
    Department of Pathology, University of Michigan Medical School, 1301 Catherine Road, Ann Arbor, MI 48109, USA
    J Immunol 177:1306-13. 2006
    ..As a result, CXC chemokines increase in lung, setting the stage for neutrophil accumulation in lung during sepsis...
  80. ncbi Closure of the femoral artery after cardiac catheterization: a comparison of Angio-Seal, StarClose, and manual compression
    J H H Deuling
    Department of Cardiology, Thorax Center, University Medical Center Groningen, University of Groningen, The Netherlands
    Catheter Cardiovasc Interv 71:518-23. 2008
    ..To compare Angio-Seal (AS) and StarClose (SC) and manual compression (MC) on efficacy of hemostasis, complication rate, safety of early mobilization, and patient comfort...
  81. ncbi Initial experience with the Cardiva Boomerang vascular closure device in diagnostic catheterization
    Brendan J Doyle
    Division of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota 55905, USA
    Catheter Cardiovasc Interv 69:203-8. 2007
    ..The authors studied the safety and efficacy of the Cardiva Boomerang vascular closure device in patients undergoing diagnostic cardiac catheterization...
  82. ncbi Hydrogen sulfide acts as an inflammatory mediator in cecal ligation and puncture-induced sepsis in mice by upregulating the production of cytokines and chemokines via NF-kappaB
    Huili Zhang
    Dept of Pharmacology, National University of Singapore, Singapore
    Am J Physiol Lung Cell Mol Physiol 292:L960-71. 2007
    ..Therefore, H2S upregulates the production of proinflammatory mediators and exacerbates the systemic inflammation in sepsis through a mechanism involving NF-kappaB activation...
  83. ncbi Moving in the right direction
    George W Vetrovec
    Catheter Cardiovasc Interv 70:634. 2007
  84. ncbi Development of a lethal model of peritonitis for assessment of laparoscopic and laparotomic treatments in rats
    Wilson Salgado Júnior
    Gastroenterology Division, Department of Surgery and Anatomy, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, 14048 900 Ribeirao Preto, SP, Brazil
    Acta Cir Bras 22:39-42. 2007
    ..Development of a lethal model of peritonitis to assess the results of treating that peritonitis using videolaparoscopy and laparotomy...
  85. pmc Blunt atrial transseptal puncture using excimer laser in swine
    Abdalla A Elagha
    Cardiovascular Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA
    Catheter Cardiovasc Interv 70:585-90. 2007
    ..We describe a new approach that may enhance safety of atrial transseptal puncture using a commercially available laser catheter that is capable of perforation only when energized. We test this approach in swine...
  86. ncbi Upregulation of cardiovascular ghrelin receptor occurs in the hyperdynamic phase of sepsis
    Rongqian Wu
    Division of Surgical Research, Department of Surgery, North Shore University Hospital and Long Island Jewish Medical Center, Manhasset, New York 11030, USA
    Am J Physiol Heart Circ Physiol 287:H1296-302. 2004
    ..These results demonstrate that GHSR-1a expression is upregulated and vascular sensitivity to ghrelin stimulation is increased in the hyperdynamic phase of sepsis...
  87. ncbi Impact of the Duett sealing device on quality of life and hospitalization costs for coronary diagnostic and interventional procedures: Results from the Study of Economic and Quality of Life substudy of the SEAL trial
    Z Zhang
    Division of Cardiology, Emory University School of Medicine, Atlanta, GA, USA
    Am Heart J 142:982-8. 2001
    ..02). CONCLUSIONS: The Duett sealing device was associated with significantly higher functional status at 7 days after the procedure in addition to shortened time to hemostasis and ambulation, with no associated increase in cost...
  88. ncbi Local vascular complications after use of the hemostatic puncture closure device Angio-Seal
    C Kirchhof
    Department of Medicine, Park Krankenhaus Leipzig Südost GmbH, Leipzig, Germany
    Vasa 31:101-6. 2002
    ..Here we report about the diagnosis and therapy of femoral artery complications after use of the closure device Angio-Seal, consisting of an intraarterial anchor and extravascular collagen plug...
  89. ncbi Modulation of the phosphoinositide 3-kinase pathway alters innate resistance to polymicrobial sepsis
    David L Williams
    Department of Surgery, James H Quillen College of Medicine, East Tennessee State University, PO Box 70575, Johnson City, TN 37614, USA
    J Immunol 172:449-56. 2004
    ..This suggests that stimulation of the PI3K pathway may be an effective approach for preventing or treating sepsis and/or septic shock...
  90. ncbi Hemodynamic and cardiac contractile function during sepsis caused by cecal ligation and puncture in mice
    Weike Tao
    Department of Anesthesiology, University of Texas Medical Branch and Shriners Hospital for Children, Galveston, Texas 77555 0591, USA
    Shock 21:31-7. 2004
    ..The miniaturized conductance catheter allows for effective measurements of hemodynamic function in septic mice and provides measurements that cannot be obtained using other cardiovascular monitoring techniques...
  91. ncbi A role for CD21/CD35 and CD19 in responses to acute septic peritonitis: a potential mechanism for mast cell activation
    J L Gommerman
    Department of Pathology, Center for Blood Research and Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 165:6915-21. 2000
    ..Taken together, these findings suggest that the engagement of complement receptors CD21/CD35 along with CD19 on the mast cell surface by C3 fragments may be necessary for the full expression of mast cell activation in the CLP model...
  92. ncbi Restick following initial Angioseal use
    Robert J Applegate
    Section of Cardiology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Catheter Cardiovasc Interv 58:181-4. 2003
    ..There were no major bleeding, vascular repair, vessel occlusion, or embolizations. Three large hematomas (1.7%) were noted. These data suggest that restick can be performed safely after initial Angioseal deployment...
  93. ncbi Clinical evaluation of SyvekPatch in patients undergoing interventional, EPS and diagnostic cardiac catheterization procedures
    R G Nader
    Mt Sinai Medical Center and Miami Heart Institute, Miami Beach, FL, USA
    J Invasive Cardiol 14:305-7. 2002
    ..A clinical evaluation was designed to determine the efficacy and safety of this vascular closure device in 1,000 consecutive patients after routine diagnostic and interventional procedures...
  94. ncbi Effects of arginine-enriched total parenteral nutrition on inflammatory-related mediator and T-cell population in septic rats
    Chiu Li Yeh
    Institute of Nutrition and Health Science, Taipei Medical University, Taipei, Taiwan, Republic of China
    Nutrition 18:631-5. 2002
    ..However, the effects of parenterally infused Arg on sepsis are not well understood. We used a septic rat model to study Arg infusion in inflammatory-related cytokines and blood T lymphocyte population in vivo...
  95. ncbi Anti-IL-10 therapeutic strategy using the immunomodulator AS101 in protecting mice from sepsis-induced death: dependence on timing of immunomodulating intervention
    Yona Kalechman
    C A I R Institute, Faculty of Life Sciences, Bar Ilan University, Ramat Gan, Israel
    J Immunol 169:384-92. 2002
    ....
  96. ncbi Effect of sodium arsenite on iNOS expression and vascular hyporeactivity associated with cecal ligation and puncture in the rat
    G J Hauser
    Division of Pediatric Critical Care Medicine, Georgetown University Children's Medical Center, Washington, District of Columbia 20007, USA
    Shock 15:73-6. 2001
    ....
  97. ncbi Sepsis induces apoptosis and profound depletion of splenic interdigitating and follicular dendritic cells
    Kevin W Tinsley
    Department of Anesthesiology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 171:909-14. 2003
    ..IDC death occurred by caspase 3-mediated apoptosis. Such profound apoptosis induced loss of FDCs and IDCs may significantly compromise B and T cell function and impair the ability of the host to survive sepsis...
  98. ncbi Reduced vascular complications after percutaneous coronary interventions with a nonmechanical suture device: results from the randomized RACE study
    Timothy A Sanborn
    Evanston Northwestern Healthcare, Evanston, Illinois 60201, USA
    Catheter Cardiovasc Interv 61:327-32. 2004
    ..The incidence of major complications after PCI was reduced with the device...
  99. pmc To plug or not to plug?
    Joseph Varon
    The University of Texas Health Science Center, St Luke s Episcopal Hospital, Houston, Texas, USA
    Crit Care 8:87-8. 2004
    ..Further, well designed studies are necessary to document the comparative effects of these devices versus manual compression...
  100. ncbi A new interventional procedure in the treatment of iatrogenic pseudoaneurysm
    Roberto Marcello
    UOC di Radiologia Interventistica e dell Alta Tecnologia, ACO San Filippo Neri, Rome, Italy
    Radiol Med 105:63-8. 2003
    ..The purpose of this study was to test the validity and the efficacy of a new interventional procedure in the treatment of iatrogenic pseudoaneurysms...
  101. ncbi Differential expression of cytochrome P450 isoforms in the lungs of septic animals
    Xiaoxuan Cui
    Division of Surgical Research, Department of Surgery, North Shore University Hospital and Long Island Jewish Medical Center, Manhasset, NY 11030, USA
    Crit Care Med 32:1186-91. 2004
    ....

Research Grants53

  1. Pathogenic Mechanism for Lung Infection in Mucoid Pseudomonas
    DENNIS EDWARD OHMAN; Fiscal Year: 2013
    ..bacterium can result in nosocomial infections, which is common via respiratory ventilators, catheters, lumbar punctures and general surgery. P...
  2. Phenotype-Genotype Associations with Symptoms During Childhood Leukemia Treatment
    Michael E Scheurer; Fiscal Year: 2013
    ..CSF oxidative stress and cytokine biomarkers will be obtained with all therapeutic lumbar punctures occurring at four time points during post-induction therapy...
  3. Childhood Leukemia: Oxidative Stress, Cognitive Changes &Academic Outcomes
    IDA MARIE MOORE; Fiscal Year: 2013
    ..CSF samples will be obtained during diagnostic and therapeutic lumbar punctures for measuring oxidative stress. Aims 1 and 2 will be addressed using mixed model ANOVAs...
  4. A Nanofibrous Bioactive Hemodialysis Access Graft
    SAIF G PATHAN; Fiscal Year: 2013
    ..grafts into a canine arteriovenous shunt access model for 30 and 60 days in conjunction with numerous needle punctures and 5) macroscopically and histologically analyze explanted BioAccess and ePTFE grafts...
  5. Novel antithrombotic agents to prevent hemodialysis vascular access failure
    TZE CHEIN WUN; Fiscal Year: 2013
    ..Surgical trauma, repeated needle punctures, mechanical shear stress, the foreign graft material and uremia can elicit a strong thrombotic response that ..
  6. Multi-lumen steerable needles for transoral access to lung nodules
    Ron Alterovitz; Fiscal Year: 2013
    ..by image-guided steering) and pneumothorax (since, in contrast to transthoracic needle biopsy, our device never punctures the pleura around the lung)...
  7. Stabilization Device for Transseptal Access
    MARK CHRISTIAN SVENDSEN; Fiscal Year: 2013
    ..constant movement of the heart and the thin and slippery nature of the fossa ovalis (FO) make standard TS access punctures unpredictable...
  8. Neural Correlates of Working Memory Training for HIV Patients
    Linda Chang; Fiscal Year: 2013
    ..assess changes in neuroinflammatory markers and monoamine metabolites in the CSF of those who consent to lumbar punctures before and 6 months after training, and evaluate the relationships between these CSF makers, cognitive ..
  9. The Effects of Rosiglitazone in Patients with MCI
    Suzanne Craft; Fiscal Year: 2009
    ..A subset of participants will receive lumbar punctures before and following treatment to determine whether rosiglitazone affects cerebrospinal fluid (CSF) levels of ..
  10. RNA Biosignatures in the Emergency Evaluation of Febrile Infants
    Octavio Ramilo; Fiscal Year: 2013
    ..a significant and beneficial impact by reducing the number of (1) unnecessary invasive tests (including lumbar punctures), (2) use of empirical antibiotics, (3) hospitalizations and associated iatrogenic complications, and (4) ..
  11. Linking apparatus dynamics to interbacterial intoxication by type VI secretion
    Paul A Wiggins; Fiscal Year: 2013
    ..Though the T6SS is often described as a bacteriophage-like pathway that "punctures" recipient cells and injects toxins, a functioning T6S apparatus and the effects it exerts on recipient cells ..
  12. Resources, Parent-Child Communication and Adjustment to Pediatric Cancer
    Louis A Penner; Fiscal Year: 2013
    ..g., lumbar punctures) are one of the most stressful aspects of pediatric cancer;and thus (c) negative responses to these procedures (..
  13. BEHAVIORAL INTERVENTION FOR CHILDREN WITH CANCER
    Lonnie Zeltzer; Fiscal Year: 1990
    ..and observer (obs.) ratings and a behavioral checklist during 2 bone marrow aspirations and/or 2 lumbar punctures prior to intervention. Pts...
  14. NONINVASIVE DEVICE FOR SEALING VASCULAR ACCESS PUNCTURES
    Thomas Anderson; Fiscal Year: 2001
    ....
  15. Sealing Air Leaks by Inductive Coagulation Following Lung Surgery
    KEVIN MARCHITTO; Fiscal Year: 2006
    ..Pilot testing of the device has proven feasibility for sealing dialysis needle perforations, femoral artery punctures, and anastomosing arteries. The non-contact process is safe, easy to use and inexpensive...
  16. Training Simulator for Epidural Needle Insertion
    Bruce Anderson; Fiscal Year: 2002
    ..Between each vertebra will be a novel actuator and position sensor. When a Touhy needle punctures the artificial skin, it enters a computer controlled haptic feedback, virtual environment...
  17. Training Simulator for Epidural Needle Insertion
    JOHN MAGILL; Fiscal Year: 2006
    ..When a Touhy needle punctures the artificial skin, it will encounter, the novel, haptic feedback device, the feasibility of which was ..
  18. NOVEL PROTECTIVE UNDERGLOVE
    Bakul Bhatt; Fiscal Year: 2004
    ..This technology has been developed to reduce transmission of bacteria and bloodborne pathogens. Glove punctures are frequent, and the potential for pathogen transmission is increasingly significant...
  19. Parental Role in Pediatric Cancer Pain and Survivorship
    Terrance Albrecht; Fiscal Year: 2005
    Children with cancer experience stress/trauma during certain treatment-related procedures (e.g.,lumbar punctures, bone marrow aspirations)...
  20. STABILITY OF INFANT RESPONSES TO PAINFUL PROCEDURES
    Jane Evans; Fiscal Year: 2000
    ..Tissue damage from heel lances, intravenous punctures, and other standard caregiving procedures results in permanent structural changes in the brain and spinal cord ..
  21. CELLULAR MECHANISMS OF AXONAL REPAIR AND DEGENERATION
    Harvey Fishman; Fiscal Year: 2004
    ..vesicles) that we showed are necessary for successful repair (sealing) of axolemmal lesions (transections and punctures) to prevent degeneration of invertebrate giant axons (GAs) or mammalian axons...
  22. NEUROPSYCHOLOGICAL ASPECTS OF STAGE II/III HIV INFECTION
    HUGH HANDSFIELD; Fiscal Year: 1991
    ..of the HIV-infected subjects (30 each with group II and group III HIV infection) will undergo annual lumbar punctures with cerebrospinal fluid culture for HIV and determination of intrathical production of antibody to HIV...
  23. NONINVASIVE DEVICE FOR SEALING VASCULAR ACCESS PUNCTURES
    Thomas Anderson; Fiscal Year: 2004
    ..abstract_text> ..
  24. Percutaneous MR Guided Creation of a Meso-Caval Shunt
    Aravind Arepally; Fiscal Year: 2008
    ..aims will support these goals: (1) Develop a novel intravascular needle system to perform MR-guided vena cava punctures; (2) Develop and implement an MRI protocol that will provide complete real-time 3D anatomical definition of ..
  25. Antiretroviral-Induced Defects in Muscle Protein Synthesis
    Charles H Lang; Fiscal Year: 2010
    ..Such data is needed to both realize the full potential and avoid possible pitfalls of this drug in the long-term treatment of HIV-infected individuals. ..
  26. MYOCARDIAL PROTEIN SYNTHESIS AFTER ALCOHOL INTOXICATION
    Charles H Lang; Fiscal Year: 2010
    ..Overall, the research design will establish the mechanism by which myocardial protein synthesis is reduced in response to alcohol abuse. ..
  27. Myocardial Protein Synthesis After Thermal Injury
    Charles Lang; Fiscal Year: 2005
    ..Overall, the research will elucidate the mechanisms by which myocardial protein synthesis is reduced after thermal injury, leading to the better understanding and treatment of the resulting cardiomyopathy. - ..
  28. Novel Methods to Access Brain Function in HIV-1
    Christina Marra; Fiscal Year: 2003
    ..abstract_text> ..
  29. ALZHEIMER'S IN LONG TERM PROPRANOLOL FOR AGITATION
    Elaine Peskind; Fiscal Year: 2003
    ..We will determine if high plasma NE and/or high lymphocyte beta-adrenergic receptor density, affinity, and/or sensitivity define AD patients with disruptive agitation most responsive to propranolol. ..
  30. ORGAN HEMOSTASIS IN TRAUMA BY HIGH INTENSITY ULTRASOUND
    Shahram Vaezy; Fiscal Year: 2003
    ..Thus, the investigators believe that their proposed studies will result in a new and clinically applicable methodology for reducing mortality and morbidity in abnormal trauma. ..
  31. SPINAL BENDING MOTIONS FOR PREVENTING DISC DEGENERATION
    Adam Hsieh; Fiscal Year: 2003
    ..These regimens will then be tested experimentally to determine the effects on biosynthesis and apoptosis. ..
  32. UTERINE TUMOR TREATMENT USING HIGH INTENSITY ULTRASOUND
    Shahram Vaezy; Fiscal Year: 2003
    ..Ultimately, this treatment approach may also provide an option to preserve fertility and improve reproductive outcomes in patients with fibroid tumors. ..
  33. ANALYSIS OF ASSOCIATION BETWEEN C. PNEUMONIAE AND MS
    Subramaniam Sriram; Fiscal Year: 2002
    ..Also, the presence of an immune response to C. pneumoniae that is contained within the CNS compartment will constitute strong circumstantial evidence of microbial infection. ..
  34. Dietary supplementation with glucan enhances immune fn
    David Williams; Fiscal Year: 2002
    ..At the successful conclusion of this research e will have established what, if any, effect dietary supplementation with glucan has on modulating immunocompetence arid whether oral glucans will increase resistance to infectious diseases. ..
  35. Pathophysiological Interpretations of Dynamic PET/CT of Molecular Liver Biology
    Susanne Keiding; Fiscal Year: 2010
    ..This will lead to improved diagnosis and treatment of the large groups of patients with liver disease and cancer in the liver. ..
  36. Ethical & Methodological Standards for Trials of Invasive Therapeutic Procedures
    Carol M Ashton; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: The project will result in substantial and much-needed improvements in the methodological and ethical quality of trials performed to evaluate invasive therapeutic procedures in humans. ..
  37. Anti-ischemic Resuscitation Fluid
    Martin Bluth; Fiscal Year: 2008
    ..abstract_text> ..
  38. Oxidative Stress Markers and HIV Dementia
    Ned Sacktor; Fiscal Year: 2009
    ..We believe that oxidative stress plays a significant role in the development of HIV-D, and strategies to decrease oxidative stress may serve as a useful therapeutic target to treat HIV-D. ..
  39. MULTI IMAGER COMPATIBLE ROBOT FOR PROSTATE ACCESS
    Dan Stoianovici; Fiscal Year: 2004
    ..The use of electricity in the imager's room will be eliminated by using optical sensors and pneumatic/hydraulic motors while all control equipment will be located in the control room of the imager. ..
  40. ROLE OF T PALLIDUM MSP-HOMOLOGUES IN CNS INVASION
    Christina Marra; Fiscal Year: 2004
    ..These investigations are most applicable to persons who are also infected with HIV-1, as they are at greatest risk for syphilis and neurosyphilis. ..
  41. STRETCH-INDUCED CYCLOOXYGENASE-2 IN UROTHELIAL CELLs
    Stephen Nakada; Fiscal Year: 2005
    ..abstract_text> ..
  42. Novel oral therapeutics for multiple sclerosis
    Subramaniam Sriram; Fiscal Year: 2006
    ....
  43. Rapid and Simple CSF Tests for Neurosyphillis Diagnosis
    Christina Marra; Fiscal Year: 2006
    ..The results of this study will be used to design field trials in the areas of greatest need. ..
  44. MATH INTERVENTION FOR CHILDREN WITH LEUKEMIA
    Ida Moore; Fiscal Year: 2004
    ..of phospholipids, a biological marker of CNS injury, will be measured in CSF samples collected when lumbar punctures are done for intrathecal therapy...
  45. ROMK CHANNEL FUNCTION AND REGULATION IN KIDNEY
    Gerhard Giebisch; Fiscal Year: 2003
    ..Patch-clamp and whole-cell current measurements will be carried out in native tubules and in an oocyte expression system, and tubule perfusion studies in ROMK knock-out mice. ..
  46. Epithelial Na channel (ENaC) polymorphisms in hyptertention
    James Stockand; Fiscal Year: 2007
    ..Preliminary results support the feasibility of this investigation and suggest that this line of inquiry will yield significant and novel findings. [unreadable] [unreadable]..
  47. Alcohol-specific modifications of glycated Hb: Novel biomarkers of alcohol abuse
    Yousef Al Abed; Fiscal Year: 2007
    ..Future studies will be designed to measure these alcohol-specific-markers in humans following binge and chronic alcohol intake. [unreadable] [unreadable] [unreadable]..
  48. Imaging of Pulmonary Cancer: Overcoming Limitations
    Jane Ko; Fiscal Year: 2007
    ..The proposed method will enable early recognition of nodule growth and, therefore, the early diagnosis of malignancy. ..
  49. Focused Ultrasound for Treatment of Nerves
    Shahram Vaezy; Fiscal Year: 2008
    ..It is our goal to develop image- guided focused ultrasound as a non-invasive alternative for the treatment of spasticity and pain. ..
  50. Biomechanical Engineering of Fibrous Load-Bearing Tissue
    Dawn Elliott; Fiscal Year: 2007
    ..Notably, this design approach for load-bearing fiberreinforced tissues, focusing on mechanics first, can be extended to other orthopaedic and cardiovascular tissue applications. ..
  51. GDF-5 Regulation in Intervertebral Disc Degeneration
    Xudong Li; Fiscal Year: 2008
    ..If successful in achieving meaningful repair, this project will help investigators make significant strides towards enabling disc repair in humans. [unreadable] [unreadable] [unreadable]..
  52. Stoichiometry and modular retrieval of ENaC
    James Stockand; Fiscal Year: 2009
    ..This research will provide critical insight about the molecualr architecture of ENaC and regulation of this important channel. ..
  53. TENDON FIBER-MATRIX MECHANICS--THEORY AND EXPERIMENTS
    Dawn Elliott; Fiscal Year: 2003
    ..This information will enable us to develop and assess potential treatment modalities. ..