phototherapy

Summary

Summary: Treatment of disease by exposure to light, especially by variously concentrated light rays or specific wavelengths.

Top Publications

  1. ncbi Phototherapy: current methods and future directions
    Hendrik J Vreman
    Department of Pediatrics, Division of Neonatal and Developmental Medicine, Stanford University School of Medicine, Stanford, CA 94305 5208, USA
    Semin Perinatol 28:326-33. 2004
  2. ncbi Immunotargeted nanoshells for integrated cancer imaging and therapy
    Christopher Loo
    Department of Bioengineering, Rice University, P O Box 1892, Houston, Texas 77251 1892, USA
    Nano Lett 5:709-11. 2005
  3. ncbi Near-infrared resonant nanoshells for combined optical imaging and photothermal cancer therapy
    Andre M Gobin
    Department of Bioengineering, Rice University, Houston, Texas 77005, USA
    Nano Lett 7:1929-34. 2007
  4. ncbi Nanoshell-enabled photonics-based imaging and therapy of cancer
    Christopher Loo
    Department of Bioengineering, Rice University, P O Box 1892, MS 142, Houston, TX 77030, USA
    Technol Cancer Res Treat 3:33-40. 2004
  5. ncbi Predischarge screening for severe neonatal hyperbilirubinemia identifies infants who need phototherapy
    Vinod K Bhutani
    Department of Neonatal and Developmental Medicine, Lucile Packard Children s Hospital, Department of Pediatrics, Stanford University, Stanford, CA 94304, USA
    J Pediatr 162:477-482.e1. 2013
  6. ncbi Phototherapy device effectiveness in Nigeria: irradiance assessment and potential for improvement
    Benjamin K Cline
    D Rev Design Revolution, San Francisco, CA 94107, USA
    J Trop Pediatr 59:321-5. 2013
  7. ncbi Age-related retinal inflammation is reduced by 670 nm light via increased mitochondrial membrane potential
    Ioannis Kokkinopoulos
    Institute of Ophthalmology, University College London, London, UK
    Neurobiol Aging 34:602-9. 2013
  8. ncbi Influence of a mindfulness meditation-based stress reduction intervention on rates of skin clearing in patients with moderate to severe psoriasis undergoing phototherapy (UVB) and photochemotherapy (PUVA)
    J Kabat-Zinn
    Stress Reduction Clinic, Center for Mindfulness in Medicine, Health Care, and Society, Department of Medicine, University of Massachusetts Medical Center, Worcester 01655 0267, USA
    Psychosom Med 60:625-32. 1998
  9. ncbi The history of photodetection and photodynamic therapy
    R Ackroyd
    Section of Surgical and Anesthetic Sciences, Division of Clinical Sciences, University of Sheffield, Royal Hallamshire Hospital, Sheffield, UK
    Photochem Photobiol 74:656-69. 2001
  10. ncbi Photobiomodulation protects the retina from light-induced photoreceptor degeneration
    Rizalyn Albarracin
    Research School of Biology, National University, Canberra, Australia
    Invest Ophthalmol Vis Sci 52:3582-92. 2011

Detail Information

Publications346 found, 100 shown here

  1. ncbi Phototherapy: current methods and future directions
    Hendrik J Vreman
    Department of Pediatrics, Division of Neonatal and Developmental Medicine, Stanford University School of Medicine, Stanford, CA 94305 5208, USA
    Semin Perinatol 28:326-33. 2004
    b>Phototherapy is the most common therapeutic intervention used for the treatment of hyperbilirubinemia...
  2. ncbi Immunotargeted nanoshells for integrated cancer imaging and therapy
    Christopher Loo
    Department of Bioengineering, Rice University, P O Box 1892, Houston, Texas 77251 1892, USA
    Nano Lett 5:709-11. 2005
    ..In a proof of principle experiment, dual imaging/therapy immunotargeted nanoshells are used to detect and destroy breast carcinoma cells that overexpress HER2, a clinically relevant cancer biomarker...
  3. ncbi Near-infrared resonant nanoshells for combined optical imaging and photothermal cancer therapy
    Andre M Gobin
    Department of Bioengineering, Rice University, Houston, Texas 77005, USA
    Nano Lett 7:1929-34. 2007
    ..Using these in a mouse model, we have demonstrated dramatic contrast enhancement for optical coherence tomography (OCT) and effective photothermal ablation of tumors...
  4. ncbi Nanoshell-enabled photonics-based imaging and therapy of cancer
    Christopher Loo
    Department of Bioengineering, Rice University, P O Box 1892, MS 142, Houston, TX 77030, USA
    Technol Cancer Res Treat 3:33-40. 2004
    ....
  5. ncbi Predischarge screening for severe neonatal hyperbilirubinemia identifies infants who need phototherapy
    Vinod K Bhutani
    Department of Neonatal and Developmental Medicine, Lucile Packard Children s Hospital, Department of Pediatrics, Stanford University, Stanford, CA 94304, USA
    J Pediatr 162:477-482.e1. 2013
    To test whether the combined use of total plasma/serum bilirubin (TSB) levels and clinical risk factors more accurately identifies infants who receive phototherapy than does the use of either method alone.
  6. ncbi Phototherapy device effectiveness in Nigeria: irradiance assessment and potential for improvement
    Benjamin K Cline
    D Rev Design Revolution, San Francisco, CA 94107, USA
    J Trop Pediatr 59:321-5. 2013
    This study investigated the effectiveness of simple-to-implement adjustments of phototherapy devices on irradiance levels in a cross-section of Nigerian hospitals...
  7. ncbi Age-related retinal inflammation is reduced by 670 nm light via increased mitochondrial membrane potential
    Ioannis Kokkinopoulos
    Institute of Ophthalmology, University College London, London, UK
    Neurobiol Aging 34:602-9. 2013
    ..These results provide a simple route to combating inflammation in an aging population with declining visual function and may be applicable to clinical conditions where retinal inflammation is a key feature...
  8. ncbi Influence of a mindfulness meditation-based stress reduction intervention on rates of skin clearing in patients with moderate to severe psoriasis undergoing phototherapy (UVB) and photochemotherapy (PUVA)
    J Kabat-Zinn
    Stress Reduction Clinic, Center for Mindfulness in Medicine, Health Care, and Society, Department of Medicine, University of Massachusetts Medical Center, Worcester 01655 0267, USA
    Psychosom Med 60:625-32. 1998
    This study tests the hypothesis that stress reduction methods based on mindfulness meditation can positively influence the rate at which psoriasis clears in patients undergoing phototherapy or photochemotherapy treatment.
  9. ncbi The history of photodetection and photodynamic therapy
    R Ackroyd
    Section of Surgical and Anesthetic Sciences, Division of Clinical Sciences, University of Sheffield, Royal Hallamshire Hospital, Sheffield, UK
    Photochem Photobiol 74:656-69. 2001
    Light has been employed in the treatment of disease since antiquity. Many ancient civilizations utilized phototherapy, but it was not until early last century that this form of therapy reappeared...
  10. ncbi Photobiomodulation protects the retina from light-induced photoreceptor degeneration
    Rizalyn Albarracin
    Research School of Biology, National University, Canberra, Australia
    Invest Ophthalmol Vis Sci 52:3582-92. 2011
    ..In this study, the hypothesis that near-infrared (NIR) light treatment (photobiomodulation) attenuates bright-light damage in the albino rat retina was tested...
  11. doi Phototherapy for neonatal jaundice
    M Jeffrey Maisels
    Department of Pediatrics, William Beaumont Hospital, Royal Oak, MI 48073, USA
    N Engl J Med 358:920-8. 2008
  12. ncbi Phototherapy for enhancing peripheral nerve repair: a review of the literature
    Davilene Gigo-Benato
    Department of Clinical and Biological Sciences, University of Turin, San Luigi Hospital, Regione Gonzole 10, Orbassano, 10043 Italy
    Muscle Nerve 31:694-701. 2005
    ..present article reviews literature on one possible rehabilitation approach for enhancing nerve recovery, namely phototherapy. The number of experimental studies that have reported on the promoting action of phototherapy on peripheral ..
  13. ncbi Phototherapy improves healing of chronic venous ulcers
    Kelly Steinkopf Caetano
    Department of Bioengineering, Faculty of Medicine, University of Sao Paulo, Ribeirao Preto, Brazil
    Photomed Laser Surg 27:111-8. 2009
    We tested the hypothesis that LED phototherapy with combined 660-nm and 890-nm light will promote healing of venous ulcers that failed to respond to other forms of treatment.
  14. ncbi Malignancy concerns with psoriasis treatments using phototherapy, methotrexate, cyclosporin, and biologics: facts and controversies
    Luigi Naldi
    Centro Studi Gruppo Italiano Studi Epidemiologici in Dermatologia and Department of Dermatology, Largo Barozzi 1, Ospedali Riuniti, 24100 Bergamo, Italy
    Clin Dermatol 28:88-92. 2010
    ..More recently, an increased risk of cancer has been a concern with newly introduced biologic agents. The documentation of such a purported increased risk requires long-term follow-up of treated patients...
  15. pmc Therapeutic photobiomodulation for methanol-induced retinal toxicity
    J T Eells
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Proc Natl Acad Sci U S A 100:3439-44. 2003
    ..They also suggest that photobiomodulation may enhance recovery from retinal injury and other ocular diseases in which mitochondrial dysfunction is postulated to play a role...
  16. ncbi Bright-light therapy in the treatment of mood disorders
    Gerald Pail
    Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria
    Neuropsychobiology 64:152-62. 2011
    ..In the third part, the mode of action, application, efficacy, tolerability and safety of BLT in SAD and other mood disorders are explored...
  17. ncbi Morning light treatment hastens the antidepressant effect of citalopram: a placebo-controlled trial
    Francesco Benedetti
    Universita Vita Salute San Raffaele, School of Medicine, Department of Neuropsychiatric Sciences, Milano, Italy
    J Clin Psychiatry 64:648-53. 2003
    ..The purpose of the present study was to evaluate the effect of morning light therapy or placebo combined with citalopram in the treatment of patients affected by a major depressive episode without psychotic features...
  18. ncbi Light therapy for seasonal and nonseasonal depression: efficacy, protocol, safety, and side effects
    Michael Terman
    Clinical Chronobiology, New York State Psychiatric Institute, New York, NY 10032, USA
    CNS Spectr 10:647-63; quiz 672. 2005
    ..Importantly, light therapy provides a compatible adjunct to antidepressant medication, which can result in accelerated improvement and fewer residual symptoms...
  19. ncbi Microcirculatory responses to acupuncture stimulation and phototherapy
    Makiko Komori
    Department of Anesthesiology, Medical Center East, Tokyo Women s Medical University, 2 1 10, Nishiogu, Arakawa ku, Tokyo 116 8567, Japan
    Anesth Analg 108:635-40. 2009
    Acupuncture stimulation and phototherapy have been reported to have analgesic effects and improve the microcirculation. However, few studies have directly examined changes in peripheral blood vessels, either quantitatively or objectively...
  20. ncbi The efficacy of light therapy in the treatment of mood disorders: a review and meta-analysis of the evidence
    Robert N Golden
    Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7160, USA
    Am J Psychiatry 162:656-62. 2005
    ..The purpose of this study was to assess the evidence base for the efficacy of light therapy in treating mood disorders...
  21. ncbi Multifunctional nanoparticles for upconversion luminescence/MR multimodal imaging and magnetically targeted photothermal therapy
    Liang Cheng
    Jiangsu Key Laboratory for Carbon Based Functional Materials and Devices, Institute of Functional Nano and Soft Materials, Soochow University, Suzhou, Jiangsu 215123, China
    Biomaterials 33:2215-22. 2012
    ..We present here a strategy for multimodal imaging-guided, magnetically targeted physical cancer therapy and highlight the promise of using multifunctional nanostructures for cancer theranostics...
  22. pmc Photothermal nanotherapeutics and nanodiagnostics for selective killing of bacteria targeted with gold nanoparticles
    Vladimir P Zharov
    Philips Classic Laser Laboratories, and Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
    Biophys J 90:619-27. 2006
    ..1-5 J/cm(2), 100 pulses), and laser-induced bacterial damage observed at different laser fluences and nanoparticle sizes was verified by optical transmission, electron microscopy, and conventional viability testing...
  23. pmc Aggressive vs. conservative phototherapy for infants with extremely low birth weight
    Brenda H Morris
    University of Texas Medical School, Houston, TX 77030, USA
    N Engl J Med 359:1885-96. 2008
    It is unclear whether aggressive phototherapy to prevent neurotoxic effects of bilirubin benefits or harms infants with extremely low birth weight (1000 g or less).
  24. ncbi Laser-induced tissue hyperthermia mediated by gold nanoparticles: toward cancer phototherapy
    Georgy S Terentyuk
    Saratov State University, Department of Optics and Biophotonics, 83 Astrakhanskaya, Saratov 410012, Russia
    J Biomed Opt 14:021016. 2009
    ..The results of temperature measurements are compared with tissue histology...
  25. ncbi Therapeutic possibilities of plasmonically heated gold nanoparticles
    Dakrong Pissuwan
    Institute for Nanoscale Technology, University of Technology Sydney, Broadway NSW 2007, Australia
    Trends Biotechnol 24:62-7. 2006
    ..Here, we review the progress made in the exploitation of the plasmon resonance of gold nanoparticles in photo-thermal therapeutic medicine...
  26. pmc Immunonanoshells for targeted photothermal ablation of tumor cells
    Amanda R Lowery
    Department of Bioengineering, Rice University, Houston, TX 77005, USA
    Int J Nanomedicine 1:149-54. 2006
    ..Control nanoshells, conjugated with nonspecific anti-IgG or PEG, did not bind to either cell type, and cells continued to be viable after treatment with these control nanoshells and NIR irradiation...
  27. ncbi Photo-thermal tumor ablation in mice using near infrared-absorbing nanoparticles
    D Patrick O'Neal
    Nanospectra Biosciences, Inc, 8285 El Rio Suite 130, Houston, TX 77054, USA
    Cancer Lett 209:171-6. 2004
    ..This simple, non-invasive procedure shows great promise as a technique for selective photo-thermal tumor ablation...
  28. pmc Nanotechnology-based molecular photoacoustic and photothermal flow cytometry platform for in-vivo detection and killing of circulating cancer stem cells
    Ekaterina I Galanzha
    Department of Biological and Agricultural Engineering and Institute for Nanoscale Materials Science and Engineering, University of Arkansas, Fayetteville, AR, 72701, USA
    J Biophotonics 2:725-35. 2009
    ....
  29. ncbi Evaluation of window-tinting films for sunlight phototherapy
    Hendrik J Vreman
    Division of Neonatal and Developmental Medicine, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305 5208, USA
    J Trop Pediatr 59:496-501. 2013
    ..The data suggest that most of the relatively low-cost window-tinting films tested can effectively reduce sunlight UV and IR and offer a range of significant attenuations of therapeutic blue light. ..
  30. pmc Development and applications of photo-triggered theranostic agents
    Prakash Rai
    Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, 02114, United States
    Adv Drug Deliv Rev 62:1094-124. 2010
    ..Specifically, we discuss recent developments in the use of theranostic agents for photodynamic-, photothermal- or photo-triggered chemotherapy for several diseases...
  31. ncbi Irradiance readings of phototherapy equipment: Nigeria
    Joshua Aderinsola Owa
    Department of Pediatrics and Child Health, Obafemi Awolowo University, Ile Ife, Osun State, Nigeria
    Indian J Pediatr 78:996-8. 2011
    b>Phototherapy devices (n = 63) at twelve nurseries in Nigeria were evaluated. Irradiance was measured using the BiliBlanket Meter II. Irradiance readings ranged from 0.5 to 18...
  32. pmc Pretreatment with near-infrared light via light-emitting diode provides added benefit against rotenone- and MPP+-induced neurotoxicity
    Rong Ying
    Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Brain Res 1243:167-73. 2008
    ..These data suggest that LED pretreatment is an effective adjunct preventative therapy in rescuing neurons from neurotoxins linked to PD...
  33. ncbi Treatment of psoriasis. Part 1. Topical therapy and phototherapy
    M Lebwohl
    Department of Dermatology, The Mount Sinai School of Medicine of New York University, New York, NY 10029, USA
    J Am Acad Dermatol 45:487-98; quiz 499-502. 2001
    New developments in the topical therapy and phototherapy of psoriasis have greatly improved our ability to safely and effectively treat this debilitating disease...
  34. ncbi Controlled trial of bright light and negative air ions for chronic depression
    Namni Goel
    Department of Psychology, 207 High Street, Judd Hall, Wesleyan University, Middletown, CT 06459, USA
    Psychol Med 35:945-55. 2005
    ..Both methods have shown clinical success for seasonal affective disorder (SAD)...
  35. ncbi Bright light therapy: side effects and benefits across the symptom spectrum
    M Terman
    Department of Psychiatry, Columbia University, New York, NY, USA
    J Clin Psychiatry 60:799-808; quiz 809. 1999
    ..This study broadens the purview to a set of 88 physical and subjective symptoms that might emerge, remit, or remain unchanged relative to baseline, thus reducing bias toward assessment of presumed side effects...
  36. ncbi Phototherapy and orange-tinted goggles for night-shift adaptation of police officers on patrol
    Diane B Boivin
    Centre for Study and Treatment of Circadian Rhythms, Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Montreal, Quebec, Canada
    Chronobiol Int 29:629-40. 2012
    ..003), whereas it remained stable in the intervention group. These observations indicate better physiological adaptation in the intervention group compared to the controls...
  37. ncbi A comparative study on efficacy of UVA1 vs. narrow-band UVB phototherapy in the treatment of vitiligo
    Bakr Mohamed El-Zawahry
    Department of Dermatology, Kasr El Ainy University Hospital, Cairo University, Cairo, Egypt
    Photodermatol Photoimmunol Photomed 28:84-90. 2012
    ..Ultraviolet A1 (UVA1) phototherapy has overlapping biological effects to NB-UVB and is relatively free of side effects associated with other ..
  38. pmc In vitro and in vivo efficacy of new blue light emitting diode phototherapy compared to conventional halogen quartz phototherapy for neonatal jaundice
    Yun Sil Chang
    Department of Pediatrics, Samsung Medical Center, Samsung Cheil Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea
    J Korean Med Sci 20:61-4. 2005
    High intensity light emitting diodes (LEDs) are being studied as possible light sources for the phototherapy of neonatal jaundice, as they can emit high intensity light of narrow wavelength band in the blue region of the visible light ..
  39. ncbi Systematic review of laser and other light therapy for the management of oral mucositis in cancer patients
    Cesar Migliorati
    Department of Diagnostic Sciences and Oral Medicine, College of Dentistry, University of Tennessee Health Sciences Center, 875 Union Avenue, suite N231, Memphis, TN 38163, USA
    Support Care Cancer 21:333-41. 2013
    ..The aim of this study was to review the available literature and define clinical practice guidelines for the use of laser and other light therapies for the prevention and treatment of oral mucositis...
  40. ncbi The need to implement effective phototherapy in resource-constrained settings
    Vinod K Bhutani
    Division of Neonatal Developmental Medicine, Department of Pediatrics, Stanford University School of Medicine, Lucile Packard Children s Hospital, Stanford, CA 94304, USA
    Semin Perinatol 35:192-7. 2011
    b>Phototherapy is the treatment of choice to reduce the severity of neonatal unconjugated hyperbilirubinemia regardless of its etiology...
  41. ncbi Circadian misalignment in mood disturbances
    Alfred J Lewy
    Oregon Health and Science University, 3181 Southwest Sam Jackson Road, Portland, OR 97239, USA
    Curr Psychiatry Rep 11:459-65. 2009
    ..Phase-advanced disorders can be treated with bright light in the evening and/or low-dose melatonin in the morning...
  42. ncbi Bright light exposure during acute tryptophan depletion prevents a lowering of mood in mildly seasonal women
    Marije aan het Rot
    Department of Psychiatry, McGill University, 1033 Pine Avenue West, Montreal, Quebec, Canada H3A 1A1
    Eur Neuropsychopharmacol 18:14-23. 2008
    ..Bright light might help protect against ATD-induced mood change by increasing serotonin above the threshold level below which there is a lowering of mood...
  43. ncbi Light emitting diodes versus compact fluorescent tubes for phototherapy in neonatal jaundice: a multi center randomized controlled trial
    Praveen Kumar
    Department of Pediatrics, Post Graduate Institute of Medical Education and Research, Chandigarh, India
    Indian Pediatr 47:131-7. 2010
    To evaluate whether light-emitting diode (LED) phototherapy is as efficacious as compact fluorescent tube (CFT) phototherapy for the treatment of non-hemolytic jaundice in healthy term and late preterm neonates.
  44. ncbi An assessment of the efficacy of blue light phototherapy in the treatment of acne vulgaris
    Sadia Ammad
    Cardiff University, Cardiff, UK
    J Cosmet Dermatol 7:180-8. 2008
    ..Studies conducted in recent years have shown favorable effects within the visible light spectrum for the treatment of acne vulgaris...
  45. ncbi Formation of photoproducts and cytotoxicity of bilirubin irradiated with turquoise and blue phototherapy light
    Ellen Bruzell Roll
    Norwegian Radiation Protection Authority, Østerås, Norway
    Acta Paediatr 94:1448-54. 2005
    To compare a new turquoise ("green") fluorescent phototherapy lamp (490 nm) with a conventional blue phototherapy lamp (450 nm) with respect to cytotoxicity and photochemical effects of bilirubin.
  46. ncbi Bright light, negative air ions and auditory stimuli produce rapid mood changes in a student population: a placebo-controlled study
    Namni Goel
    Department of Psychology, Wesleyan University, Middletown, CT 06459, USA
    Psychol Med 36:1253-63. 2006
    ..This study compared the short-term effects of bright light, an auditory stimulus, and high- and low-density negative ions on mood and alertness in mildly depressed and non-depressed adults...
  47. pmc Self-assembly synthesis, tumor cell targeting, and photothermal capabilities of antibody-coated indocyanine green nanocapsules
    Jie Yu
    Department of Chemical and Biomolecular Engineering, Rice University, Houston, Texas 77251, USA
    J Am Chem Soc 132:1929-38. 2010
    ..These results illustrate the ability to design a colloidal material with cell targeting and heat generating capabilities using noncovalent chemistry...
  48. ncbi Multifunctional polymeric nanoparticles for combined chemotherapeutic and near-infrared photothermal cancer therapy in vitro and in vivo
    Fong Yu Cheng
    Department of Chemistry, National Cheng Kung University, Tainan 701, Taiwan
    Chem Commun (Camb) 46:3167-9. 2010
    ..Multifunctional Taxol-loaded PLGA nanoparticles show chemotherapeutic and photothermal destruction of cancer cells in vitro and in vivo...
  49. pmc Copper selenide nanocrystals for photothermal therapy
    Colin M Hessel
    Department of Chemical Engineering, Texas Materials Institute, Center for Nano and Molecular Science and Technology, Austin, Texas 78712, United States
    Nano Lett 11:2560-6. 2011
    ....
  50. ncbi Therapeutic photobiomodulation: nitric oxide and a novel function of mitochondrial cytochrome c oxidase
    Robert O Poyton
    Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, Colorado 80309, USA
    Discov Med 11:154-9. 2011
    ..We also propose that the effectiveness of photobiomodulation is under the control of tissue oxygen and nitrite levels...
  51. ncbi Photorejuvenation for Asian skin by intense pulsed light
    K Negishi
    Department of Plastic and Reconstructive Surgery, Tokyo Women's Medical University, Daini Hospital, Tokyo, Japan
    Dermatol Surg 27:627-31; discussion 632. 2001
    ..CONCLUSION: Photorejuvenation using IPL is a completely safe and effective procedure even for Asian skin. It will be increasingly used for skin rejuvenation in the future...
  52. ncbi Winter seasonal affective disorder: a follow-up study of the first 59 patients of the National Institute of Mental Health Seasonal Studies Program
    P J Schwartz
    Clinical Psychobiology Branch, NIMH, Bethesda, MD 20892, USA
    Am J Psychiatry 153:1028-36. 1996
    ..The purpose of this study was to characterize the long-term course of patients with seasonal affective disorder...
  53. pmc A light-activated theranostic nanoagent for targeted macrophage ablation in inflammatory atherosclerosis
    Jason R McCarthy
    Harvard Medical School, Boston, MA 02114, USA
    Small 6:2041-9. 2010
    ..Importantly, these agents display limited skin photosensitivity, are highly efficacious, and provide an integrated imaging and therapeutic nanoplatform for atherosclerosis...
  54. pmc Effects of an advanced sleep schedule and morning short wavelength light exposure on circadian phase in young adults with late sleep schedules
    Katherine M Sharkey
    Department of Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, Alpert Medical School of Brown University, Box G RIH, Providence, RI 02912, USA
    Sleep Med 12:685-92. 2011
    ..8±3 years; 13 women) with late sleep schedules and subclinical features of delayed sleep phase disorder (DSPD)...
  55. ncbi A randomized, placebo-controlled trial of bright light and high-density negative air ions for treatment of Seasonal Affective Disorder
    Randall Flory
    Department of Psychology, Hollins University, Roanoke, VA 24020, USA
    Psychiatry Res 177:101-8. 2010
    ....
  56. ncbi Plasmonic nanopowders for photothermal therapy of tumors
    Boris N Khlebtsov
    Institute of Biochemistry and Physiology of Plants and Microorganisms, Russian Academy of Sciences, 13 Prospekt Entuziastov, Saratov 410049, Russia
    Langmuir 28:8994-9002. 2012
    ..Particle biodistribution was measured by atomic absorption spectroscopy, and tumor hyperthermia effects were studied under laser NIR irradiation. Significant tumor damage was observed only at the higher dose of the nanorods...
  57. ncbi Multifunctional nanoparticles for combined doxorubicin and photothermal treatments
    Huiyul Park
    National Core Research Center for Nanomedical Technology, Yonsei University, Seoul 120 749, Korea
    ACS Nano 3:2919-26. 2009
    ..Since our NPs selectively deliver both heat and drug to tumorigenic regions, they may improve the therapeutic effectiveness with minimal side effects...
  58. ncbi Guidelines of care for the management of psoriasis and psoriatic arthritis: Section 5. Guidelines of care for the treatment of psoriasis with phototherapy and photochemotherapy
    Alan Menter
    Psoriasis Research Center, Baylor University Medical Center, Dallas, Texas, USA
    J Am Acad Dermatol 62:114-35. 2010
    ..We will discuss in detail the efficacy and safety as well as offer recommendations for the use of phototherapy, including narrowband and broadband UVB and photochemotherapy using psoralen plus UVA, alone and in combination ..
  59. ncbi Circadian time of morning light administration and therapeutic response in winter depression
    J S Terman
    New York State Psychiatric Institute, 1051 Riverside Dr, Unit 50, New York, NY 10032, USA
    Arch Gen Psychiatry 58:69-75. 2001
    ..CONCLUSION: The antidepressant effect of light is potentiated by early-morning administration in circadian time, optimally about 8.5 hours after melatonin onset or 2.5 hours after the sleep midpoint...
  60. ncbi Neuroprotection of midbrain dopaminergic cells in MPTP-treated mice after near-infrared light treatment
    Victoria E Shaw
    Discipline of Anatomy and Histology F13, University of Sydney, Australia
    J Comp Neurol 518:25-40. 2010
    ..In summary, our results indicate that NIr light treatment offers neuroprotection against MPTP toxicity for dopaminergic cells in the SNc, but not in the ZI-Hyp...
  61. pmc Long-term survival following a single treatment of kidney tumors with multiwalled carbon nanotubes and near-infrared radiation
    Andrew Burke
    Department of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Proc Natl Acad Sci U S A 106:12897-902. 2009
    ..These treatment parameters resulted in complete ablation of tumors and a >3.5-month durable remission in 80% of mice treated with 100 microg of MWCNT. Use of MWCNTs with NIR may be effective in anticancer therapy...
  62. pmc Effect of light treatment on sleep and circadian rhythms in demented nursing home patients
    Sonia Ancoli-Israel
    Department of Psychiatry, University of California San Diego, USA
    J Am Geriatr Soc 50:282-9. 2002
    ..To determine whether fragmented sleep in nursing home patients would improve with increased exposure to bright light...
  63. pmc In vitro and in vivo targeting of hollow gold nanoshells directed at epidermal growth factor receptor for photothermal ablation therapy
    Marites P Melancon
    Department of Experimental Diagnostic Imaging, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Mol Cancer Ther 7:1730-9. 2008
    Laser-induced phototherapy is a new therapeutic use of electromagnetic radiation for cancer treatment. The use of targeted plasmonic gold nanoparticles can reduce the laser energy necessary for selective tumor cell destruction...
  64. ncbi Core-shell hybrid nanogels for integration of optical temperature-sensing, targeted tumor cell imaging, and combined chemo-photothermal treatment
    Weitai Wu
    Department of Chemistry of College of Staten Island, and The Graduate Center, The City University of New York, Staten Island, NY 10314, USA
    Biomaterials 31:7555-66. 2010
    ..The ability of the hybrid nanogels to combine the local specific chemotherapy with external NIR photothermal treatment significantly improves the therapeutic efficacy due to a synergistic effect...
  65. ncbi Laser-induced explosion of gold nanoparticles: potential role for nanophotothermolysis of cancer
    Renat R Letfullin
    Department of Physics and Optical Engineering, Rose Hulman Institute of Technology, Terre Haute, IN 47803 3999, USA
    Nanomedicine (Lond) 1:473-80. 2006
    ..This article explores the laser-induced explosion of absorbing nanoparticles in selective nanophotothermolysis of cancer...
  66. pmc Near-infrared-resonant gold/gold sulfide nanoparticles as a photothermal cancer therapeutic agent
    Andre M Gobin
    Department of Bioengineering, Rice University MS 142, 6100 S Main St, Houston, TX 77251, USA
    Small 6:745-52. 2010
    ..Furthermore, enhanced circulation and biodistribution is observed in vivo. This class of NIR-absorbing nanoparticles has the potential to improve upon photothermal tumor ablation for cancer therapy...
  67. ncbi Hyperbaric oxygen and malignancies: a potential role in radiotherapy, chemotherapy, tumor surgery and phototherapy
    Noori S Al-Waili
    Life Support Technologies, Inc, The Mount Vernon Hospital, New York 10550, USA
    Med Sci Monit 11:RA279-89. 2005
    ..HBO2 is a relatively benign with few contraindications, even for active cancer patients...
  68. ncbi Effects of low-level light therapy on streptozotocin-induced diabetic kidney
    Jinhwan Lim
    School of Public and Environmental Affairs, Indiana University, 1315 East Tenth Street, Bloomington, IN 47405, United States
    J Photochem Photobiol B 99:105-10. 2010
    ..Thus, 670nm LLLT may be broadly applicable to the amelioration of renal complications induced by diabetes that disrupt antioxidant defense mechanisms...
  69. ncbi The Can-SAD study: a randomized controlled trial of the effectiveness of light therapy and fluoxetine in patients with winter seasonal affective disorder
    Raymond W Lam
    Mood Disorders Centre, UBC Hospital, 2255 Wesbrook Mall, Vancouver, BC V6T 2A1
    Am J Psychiatry 163:805-12. 2006
    ..This study compared the effectiveness of light therapy and an antidepressant within a single trial...
  70. ncbi A controlled trial of timed bright light and negative air ionization for treatment of winter depression
    M Terman
    Department of Psychiatry, Columbia University, New York State Psychiatric Institute, New York 10032, USA
    Arch Gen Psychiatry 55:875-82. 1998
    ..Past studies, however, have lacked adequate placebo controls or sufficient power to detect group differences. The importance of time of day of treatment--specifically, morning light superiority--has remained controversial...
  71. ncbi Immunonanoshells for targeted photothermal ablation in medulloblastoma and glioma: an in vitro evaluation using human cell lines
    Ronald J Bernardi
    Texas Children s Cancer Center, Texas Children s Hospital, Baylor College of Medicine, Houston, TX, USA
    J Neurooncol 86:165-72. 2008
    ....
  72. ncbi Self-assembling nanoclusters in living systems: application for integrated photothermal nanodiagnostics and nanotherapy
    Vladimir P Zharov
    Philips Classic Laser Laboratories, The Arkansas Cancer Research Center, The University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
    Nanomedicine 1:326-45. 2005
    ....
  73. ncbi A randomized, double-blind, placebo-controlled study of light therapy for antepartum depression
    Anna Wirz-Justice
    Centre for Chronobiology, Psychiatric Hospitals of the University of Basel, Wilhelm Klein Strasse 27, CH 4012 Basel, Switzerland
    J Clin Psychiatry 72:986-93. 2011
    ..Affective disorder during pregnancy is a common condition requiring careful judgment to treat the depression while minimizing risk to the fetus. Following up on promising pilot trials, we studied the efficacy of light therapy...
  74. ncbi Are recommended phototherapy thresholds safe enough for extremely low birth weight (ELBW) infants? A report on 2 ELBW infants with kernicterus despite only moderate hyperbilirubinemia
    M Moll
    Department of Neonatology, University Children s Hospital, Tuebingen, Germany
    Neonatology 99:90-4. 2011
    ..8 months corrected age despite only moderate neonatal hyperbilirubinemia (peak serum bilirubin <10 g/dl) and phototherapy being applied according to current guidelines...
  75. ncbi Improvement in behavioral symptoms and advance of activity acrophase after short-term bright light treatment in severe dementia
    Arvid Skjerve
    Olaviken Treatment Center, University of Bergen, Bergen, Norway
    Psychiatry Clin Neurosci 58:343-7. 2004
    ..There was an advance of the activity rhythm acrophase during treatment. These results suggest that short-time bright light improves behavioral symptoms and aspects of activity rhythm disturbances even in severely demented subjects...
  76. ncbi Bright light treatment of winter depression: a placebo-controlled trial
    C I Eastman
    Department of Psychology, Rush Presbyterian St Luke s Medical Center, Chicago, Ill 60612, USA
    Arch Gen Psychiatry 55:883-9. 1998
    ..However, the studies with the best placebo controls have not been able to demonstrate that light treatment has a benefit beyond its placebo effect...
  77. ncbi Cognitive-behavioral therapy, light therapy, and their combination in treating seasonal affective disorder
    Kelly J Rohan
    Uniformed Services University of the Health Sciences, Department of Medical and Clinical Psychology, 4301 Jones Bridge Road, Bethesda, MD 20814 4799, USA
    J Affect Disord 80:273-83. 2004
    ..Because preliminary studies suggest that cognitive and behavioral factors are involved in SAD, cognitive-behavioral therapy (CBT) warrants investigation as a possible treatment option...
  78. ncbi A comparative study of the effects of laser photobiomodulation on the healing of third-degree burns: a histological study in rats
    Gyselle C S Meirelles
    Laser Center, School of Dentistry, Department of Propedeutics and Integrated Clinics, Universidade Federal da Bahia, Salvador, Brazil
    Photomed Laser Surg 26:159-66. 2008
    ..The aim of this investigation was to compare by light microscopy the effects of laser photobiomodulation at wavelengths of 660 and 780 nm on third-degree burns in Wistar rats...
  79. ncbi When should phototherapy be stopped? A pilot study comparing two targets of serum bilirubin concentration
    Mila Barak
    Department of Neonatology, Lis Maternity Hospital, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    Acta Paediatr 98:277-81. 2009
    The objective of this study was to compare the outcome of two groups of jaundiced newborns randomized to one of the two targets of total serum bilirubin (TSB) for phototherapy discontinuation.
  80. ncbi Effects of intense pulsed light on sun-damaged human skin, routine, and ultrastructural analysis
    Victor G Prieto
    Department of Pathology, UT MD Anderson Cancer Center, Houston, Texas 77030, USA
    Lasers Surg Med 30:82-5. 2002
    ..New, non-ablative methods can be used in skin rejuvenation. Histologic analysis of non-ablative IPL effects on facial, sun-damaged skin...
  81. ncbi Clear topical ointment decreases transepidermal water loss in jaundiced preterm infants receiving phototherapy
    Siriwan Wananukul
    Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
    J Med Assoc Thai 85:102-6. 2002
    ..The treatment group received 3.0 ml of clear topical ointment just before phototherapy. Conventional phototherapy was placed above the incubators in both groups...
  82. ncbi Nanoshells for photothermal cancer therapy
    Jennifer G Morton
    Rice University, Houston, TX, USA
    Methods Mol Biol 624:101-17. 2010
    ..Nanoshells can also be made to strongly scatter light and therefore can be used in various imaging modalities such as dark-field microscopy and optical coherence tomography (OCT)...
  83. ncbi [Chronotherapy for affective disorders]
    R Lieverse
    Psychiatrie en Neuropsychologie, Maastricht University, Maastricht, The Netherlands
    Tijdschr Psychiatr 54:527-37. 2012
    ..In the literature there is increasing interest in the chronobiology of affective disorders and in the most important chronotherapies for treating these disorders...
  84. ncbi A study of the effects of phototherapy dose interval on photobiomodulation of cell cultures
    Philip Brondon
    Laser Center, Rochester General Hospital, Rochester, New York 14621 3095, USA
    Lasers Surg Med 36:409-13. 2005
    Dosimetry and treatment frequency are controversial phototherapy issues. Efficacy of dose fractionation on photobiomodulation was evaluated in vitro.
  85. ncbi A randomized, triple-blind, placebo-controlled trial of prophylactic oral phenobarbital to reduce the need for phototherapy in G6PD-deficient neonates
    Srinivas Murki
    Division of Neonatology, Department of Pediatrics, Postgraduate Institute of Medical Education and Research, Chandigarh, India
    J Perinatol 25:325-30. 2005
    ..The role of enzyme inducers, like phenobarbital, in G6PD deficiency is unclear. This randomized controlled trial was performed to evaluate Phenobarbital's role in reducing the need for phototherapy among G6PD-deficient neonates.
  86. ncbi Ultraviolet protective properties of branded and unbranded sunglasses available in the Indian market in UV phototherapy chambers
    Atul M Dongre
    Department of Dermatology, Seth G S Medical College and KEM Hospital, Parel, Mumbai, India
    Indian J Dermatol Venereol Leprol 73:26-8. 2007
    Patients receiving phototherapy for various dermatoses are at increased risk of eye damage due to ultraviolet (UV) rays. They are prescribed UV protective sunglasses by dermatologists but their exact protecting effects are not known.
  87. ncbi A prospective randomized controlled study of phototherapy using blue and blue-green light-emitting devices, and conventional halogen-quartz phototherapy
    Daniel S Seidman
    Department of Obstetrics and Gynecology, Chain Medical Center, Tel Hashomer and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    J Perinatol 23:123-7. 2003
    To determine the efficacy of blue versus blue-green phototherapy using new light sources with narrow luminous spectra...
  88. ncbi Phototherapy utilization for psoriasis is declining in the United States
    Tamara Salam Housman
    Bristol Myers Squibb Center for Dermatology Research, and Department of Dermatology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1071, USA
    J Am Acad Dermatol 46:557-9. 2002
    b>Phototherapy is an established treatment modality for psoriasis. The use of phototherapy for psoriasis appears to be in decline in nonfederal and non-university-based settings...
  89. ncbi Light-emitting diode phototherapy for unconjugated hyperbilirubinaemia in neonates
    Praveen Kumar
    Department of Pediatrics, Neonatal Unit, Postgraduate Institute of Medical Education and Research, Chandigarh, India, 16012
    Cochrane Database Syst Rev 12:CD007969. 2011
    b>Phototherapy is the mainstay of treatment of neonatal hyperbilirubinaemia. The commonly used light sources for providing phototherapy are special blue fluorescent tubes, compact fluorescent tubes and halogen spotlights...
  90. ncbi Early isomerization of bilirubin in phototherapy of neonatal jaundice
    Khalaf Mreihil
    Neonatal Intensive Care Unit, Children s and Youth Clinic, Akershus University Hospital, N 1478 Nordbyhagen, Norway
    Pediatr Res 67:656-9. 2010
    Neonatal jaundice is usually treated with phototherapy that converts bilirubin to more polar stereoisomers. These should theoretically be less able to cross the blood-brain barrier...
  91. ncbi Blue light phototherapy in the treatment of acne
    Tien Yi Tzung
    Department of Dermatology, Veterans General Hospital Kaohsiung, 386 Ta Chung 1st Road, Kaohsiung 813, Taiwan
    Photodermatol Photoimmunol Photomed 20:266-9. 2004
    ..Blue light irradiation is known to be effective against acne. However, the profile of a good candidate is still unclear...
  92. ncbi The expression of matrix metalloproteinase-1 mRNA induced by ultraviolet A1 (340-400 nm) is phototherapy relevant to the glutathione (GSH) content in skin fibroblasts of systemic sclerosis
    Lei Yin
    Department of Geriatric and Environmental Dermatology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    J Dermatol 30:173-80. 2003
    ..These data support the concept that clinical responses to UVA1 radiation are influenced by the antioxidative state of the patients' skin...
  93. pmc Effect of simulated dawn on quality of sleep--a community-based trial
    Sami Leppämäki
    Department of Mental Health and Alcohol Research, National Public Health Institute, Helsinki, Finland
    BMC Psychiatry 3:14. 2003
    ..Disturbances in sleep patterns are common and may compromise wellbeing even in the short term. Our hypothesis was that simulated dawn could improve the subjective quality of sleep during winter...
  94. ncbi Pro- and anti-inflammatory cytokine content in human peripheral blood after its transcutaneous (in vivo) and direct (in vitro) irradiation with polychromatic visible and infrared light
    Natalya A Zhevago
    Photobiology Unit, Institute of Cytology of the Russian Academy of Sciences, St Petersburg
    Photomed Laser Surg 24:129-39. 2006
    ....
  95. ncbi Total oxidant/antioxidant status in jaundiced newborns before and after phototherapy
    Ali Aycicek
    Children s Hospital at Sanliurfa, Sanliurfa, Turkey
    J Pediatr (Rio J) 83:319-22. 2007
    To assess the effect of phototherapy on serum oxidant and antioxidant status in hyperbilirubinemic full-term newborns.
  96. ncbi Therapy of circadian rhythm disorders in chronic fatigue syndrome: no symptomatic improvement with melatonin or phototherapy
    G Williams
    Diabetes and Endocrinology Research Group, Department of Medicine, University Hospital Aintree, Liverpool, UK
    Eur J Clin Invest 32:831-7. 2002
    ..We aimed to determine whether CFS symptoms were alleviated by melatonin and bright-light phototherapy, which have been shown to improve circadian rhythm disorders and fatigue in jet-lag and shift workers.
  97. ncbi Narrowband UV-B vs medium-dose UV-A1 phototherapy in chronic atopic dermatitis
    Franz J Legat
    Arch Dermatol 139:223-4. 2003
  98. ncbi Quality of life in psoriasis improves after standardized administration of narrowband UVB phototherapy
    Cathy Lim
    Honorary Research Fellow, Skin and Cancer Foundation Australia, Darlinghurst, New South Wales, Australia
    Australas J Dermatol 47:37-40. 2006
    ..Our aim was to investigate if narrowband UVB phototherapy administered to psoriatic patients in a standardized manner leads to an improvement in patients' perceived ..
  99. ncbi Extraocular light therapy in winter depression: a double-blind placebo-controlled study
    K M Koorengevel
    Department of Psychiatry, Groningen, The Netherlands
    Biol Psychiatry 50:691-8. 2001
    ..CONCLUSIONS: The response to extraocular light therapy in SAD patients did not exceed its placebo effect. Extraocular light did not induce a phase shift of the circadian pacemaker...
  100. ncbi Narrow-band blue-light treatment of seasonal affective disorder in adults and the influence of additional nonseasonal symptoms
    Robert E Strong
    Mood Disorders Clinic, Department of Psychiatry, University of Utah Health Sciences Center, Salt Lake City, Utah, USA
    Depress Anxiety 26:273-8. 2009
    ..To more stringently test the importance of these wavelengths, bright red-light was used for the placebo (control) condition...
  101. ncbi Spectral responses of the human circadian system depend on the irradiance and duration of exposure to light
    Joshua J Gooley
    Division of Sleep Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Sci Transl Med 2:31ra33. 2010
    ..These results suggest that light therapy for sleep disorders and other indications might be optimized by stimulating both photoreceptor systems...

Research Grants63

  1. UV-induced collagen reduction: treating skin scleroderma
    Sewon Kang; Fiscal Year: 2005
    ..Therefore, UVA1 phototherapy holds great potential for treatment of cutaneous scleroderma in light-colored persons...
  2. Predicting Bilirubin-induced Auditory Toxicity in Infants with Severe Jaundice
    Sanjiv B Amin; Fiscal Year: 2010
    ..greatly improve identification of severely jaundiced infants who are at risk for neurotoxicity and in need of phototherapy or exchange transfusion...
  3. Dual-Receptor Targeted Nanoparticles for Photodynamic Therapy of Brain Cancer
    Ann Marie Broome; Fiscal Year: 2013
    ..NIR) spectral range, which penetrates brain tissue most efficiently for both diagnostic optical imaging and phototherapy. The objective of the proposed research is to develop Pc 4 loaded gold nanoparticle (Au NP-Pc 4) conjugates ..
  4. Lab-on-a-chip for Neonatal Hyperbilirubinemia Screening
    Vijay Srinivasan; Fiscal Year: 2012
    ..Infants with jaundice secondary to these conditions may not respond to traditional modes of therapy (such as phototherapy) until the underlying illness is addressed...
  5. Antimicrobial Phototherapy of Antibiotic Resistant Chronic Sinusitis
    MERRILL ABRAHAM BIEL; Fiscal Year: 2011
    ....
  6. Risk factors for encephalopathy in newborns with severe hyperbilirubinemia
    RICHARD PARTRIDGE WENNBERG; Fiscal Year: 2010
    ..or bilirubin photoisomers (which may comprise >20% of total serum bilirubin in patients receiving phototherapy)...
  7. Comparative Effectiveness of Biologics for Psoriasis
    Joel M Gelfand; Fiscal Year: 2010
    ..period prevalence of comparative effectiveness of existing therapies for moderate to severe psoriasis such as phototherapy, acitretin, methotrexate, cyclosporine, alefacept, etanercept, adalimumab, infliximab, and ustekinumab...
  8. Short Wavelength UV Sources for Treatment of Psoriasis
    JOSEPH SMART; Fiscal Year: 2006
    ..on fabrication of ultraviolet (UV) light emitting diodes (LEDs) in the emission range of 305 nm to 315 nm for phototherapy of psoriasis...
  9. Late adverse Impact of Getting Hyperbilrubinemia or photo Therapy (LIGHT) study
    Thomas B Newman; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Each year, hundreds of thousands of jaundiced newborns receive phototherapy to keep their bilirubin from rising to dangerous levels...
  10. Point-of Care System for Determination of Bilirubin Capacity in Neonates
    GLEN D RAMSAY; Fiscal Year: 2013
    ..other clinical parameters such as birth weight and gestational age, and administering effective treatment (phototherapy and/or the rare exchange transfusion), if dictated...
  11. A trial to determine the effect of psoriasis treatment on cardiometabolic disease
    Joel M Gelfand; Fiscal Year: 2013
    ..three treatment arms: systemic immunomodulation with TNF-I s;skin-directed therapy with ultraviolet B (UVB) phototherapy;and placebo...
  12. Point-of Care System for Determination of Bilirubin Capacity in Neonates
    GLEN D RAMSAY; Fiscal Year: 2010
    ..At that time new manage- ment guidelines in the absence of binding data coupled with wide use of phototherapy obviated their use...
  13. Psoriasis treatments, cardiovascular disease, and diabetes
    Lisa J Herrinton; Fiscal Year: 2013
    ..Risk on these drugs will be compared to risk on phototherapy without systemic agent...
  14. MULTICENTER NETWORK OF NEONATAL INTENSIVE CARE UNITS
    Kathleen A Kennedy; Fiscal Year: 2013
    ..design and implementation of numerous completed and ongoing Network randomized trials (Vitamin A, Hypothermia, Phototherapy, Surgery for NEC).], 4) a large pool of talented collaborators to provide multidisciplinary expertise [Dr...
  15. Psoriasis and the risk of diabetes
    Joel M Gelfand; Fiscal Year: 2013
    ..biomarkers which predict future development of diabetes compared to skin targeted treatment (ultraviolet B phototherapy) or placebo...
  16. Biomarkers in Phototherapy of Barrett's Esophagus
    Kenneth K Wang; Fiscal Year: 2010
    ..These studies will provide an improved understanding regarding the response of Barrett's esophagus to ablation therapy. ..
  17. TREATMENT OF CIRCADIAN SLEEP DISORDERS WITH BRIGHT LIGHT
    Steven W Lockley; Fiscal Year: 2010
    ..of this work will build the foundation for the application of new solid-state lighting technology for the phototherapy treatment of delayed sleep phase disorder, advanced sleep phase disorder, shift-work sleep disorder, jet lag, ..
  18. Treating sleep disruption in teens with millisecond light exposure during sleep
    Jamie M Zeitzer; Fiscal Year: 2013
    ..Bright light "phototherapy" is often prescribed for treatment of DSPD...
  19. A Novel Multifunctional Bionanoprobe-Based Phototherapy for Metastatic Cancers
    Wei R Chen; Fiscal Year: 2013
    ..Successful completion of this project will pave the way to future explore the potential applications of this novel multifunctional bionanoprobe in biology and medicine, particularly in cancer treatment. ..
  20. Bilirubin and Photobilirubin: Metabolism & Exretion
    Antony McDonagh; Fiscal Year: 2005
    Long-term objectives of this proposal are to fully elucidate the mechanism and effects of phototherapy of neonatal jaundice, to improve its effectiveness and safety, and to define the molecular mechanisms involved in the transport, ..
  21. Neonatal Phototherapy / Bilirubin Excretion
    DAVID LIGHTNER; Fiscal Year: 2007
    ..b>Phototherapy is the most common treatment, with hundreds of thousands of babies in the U.S...
  22. FAST PHOTOSENSITIZED REACTIONS OF AROMATIC COMPOUNDS
    LEONARD GROSSWEINER; Fiscal Year: 1992
    The objective in a phototherapy procedure is to deliver the light dose to the tissue that accomplishes the desired clinical objective, e.g...
  23. PHOTOTHERAPY OF BLADDER CANCER: NEW PHOTOSENSITIZERS
    Chi Wei Lin; Fiscal Year: 1991
    The overall goal of this project is to advance the technique of phototherapy for bladder cancer...
  24. LASER PHOTORADIATION THERAPY OF MALIGNANT TUMORS
    Michael Berns; Fiscal Year: 2002
    ..Response will be evaluated at 3 month intervals for up to one year post treatment. ..
  25. CHILDREN AS RESEARCH SUBJECTS: HISTORY AND ETHICS
    PAUL EDELSON; Fiscal Year: 2001
    ..the Salk vaccine trial (1954), the development of therapy for childhood leukemia (1955-60), the introduction of phototherapy for neonatal jaundice (1970s), the Extracorporeal Membrane Oxygenator (1980s), and the use of Azidothymidine to ..
  26. CHARACTERIZATION OF PSORALEN DNA PHOTOADDUCTS
    FRANCIS GASPARRO; Fiscal Year: 1990
    ..Recently, a new phototherapy for CTCL, photopheresis, has been developed which may serve as a prototype of a new form of photopharmacology...
  27. LASER PHOTOTHERAPY FOR THE TREATMENT OF MALIGNANCIES
    Dan Castro; Fiscal Year: 1992
    ..ATP levels after laser and Rhodamine-123 phototherapy will be quantitated by luciferin-luciferase assays allowing measurement of mitochondrial oxidative ..
  28. CHRONOBIOLOGY OF PREMENSTRUAL SYNDROME
    Barbara Parry; Fiscal Year: 1993
    ..In pilot studies, we have found that phototherapy and sleep deprivation have marked therapeutic effects in PMS patients...
  29. USE OF AN LED ARRAY FOR NEONATAL PHOTOTHERAPY
    DANIELLE ROSEN; Fiscal Year: 2000
    ..The effectiveness of phototherapy depends upon the irradiance delivered by the light source, and the amount of skin exposed to the light...
  30. EFFECT OF PHOTORADIATION THERAPY ON DNA SYNTHESIS
    ROBERT BAMBARA; Fiscal Year: 1990
    ..Results should clarify the mechanism by which HpD inhibits DNA repair, and should also define the biological role of DNA polymerase delta II...
  31. Singlet Oxygen Detector for Photodynamic Therapy
    Steven Davis; Fiscal Year: 2004
    ..Finally a real time O2 (1delta) monitor during phototherapy could be an invaluable tool for improving the efficiency of cancer cell destruction.
  32. VITAMIN D REQUIREMENT OF INFANTS
    Bruce Hollis; Fiscal Year: 1990
    ..while these infants are being fed differing vitamin D dietary regimens; 3) examine the effects of extended phototherapy on the antirachitic sterol content of human milk and how this phototherapy of the mother affects the mineral ..
  33. Ultra Sensitive Monitor for Singlet Oxygen
    Steven Davis; Fiscal Year: 2002
    ..Finally a real time O2 (1delta) monitor during phototherapy could be an invaluable tool for improving the efficiency of cancer cell destruction...
  34. DEVELOPMENT SUBSEQUENT TO JAUNDICE OF THE NEWBORN
    JEAN JEW; Fiscal Year: 1980
    ..technical procedures will be used to evaluate and compare the effectiveness of various treatments (including phototherapy, albumin, and prednisolone administration) in ameliorating behavioral and biostructural abnormalities that ..
  35. REACTIVE OXYGEN SPECIES IN MODEL BIOLOGICAL SYSTEMS
    Christopher Foote; Fiscal Year: 1993
    ..New phthalocyanine sensitizers for phototherapy that are well characterized and absorb strongly at useful wavelengths will be prepared...
  36. MOOD SLEEP & SEASONALITY--CHILDREN AND ADOLESCENTS
    WILLIAM SONIS; Fiscal Year: 1991
    ..adolescent; initiate a series of treatment studies to determine the most effective timing and duration of phototherapy for adolescents with SAD; and develop family cohorts for the study of the genetic aspects of mood, sleep and ..
  37. ALKYLLYSOPHOSPHOLIPIDS AS ANTITUMOR AGENTS
    David Lawrence; Fiscal Year: 1990
    ..provides the flexibility to choose photosensitizers that possess photophysical properties more ideal for phototherapy than HpD. Certain alkyllysophospholipids posses a strong affinity for tumor cells...
  38. PHOTOTHERAPY OF ANTIBIOTIC RESISTANT WOUND INFECTIONS
    Merrill Biel; Fiscal Year: 2000
    ..abstract_text> ..
  39. Radiopharmaceuticals for Tumor Imaging and Photodynamic Therapy
    Ravindra Pandey; Fiscal Year: 2007
    ..Another approach for developing an improved tumor-imaging and phototherapy agents (bifunctional agents) could be to replace HPPH with those compounds that exhibit a significantly higher ..
  40. MANAGEMENT OF HYPERBILIRUBINEMIA IN NEWBORNS
    Attallah Kappas; Fiscal Year: 2000
    ..oxygenase (HO) to moderate hyperbilirubinemia in preterm infants, thereby reducing or eliminating the need for phototherapy and exchange transfusions...
  41. LIGHT SHAPING TECHNIQUE FOR UV PSORIASIS THERAPIES
    PAUL SHNITSER; Fiscal Year: 2000
    Dermatologists who perform psoriasis UV phototherapy need a flexible tool that will optimize the UV radiation dose and automatically protect healthy parts of a patient s body from excessive UV radiation...
  42. COMPACT, LOW-COST, ADAPTIVE-OPTICAL RETINAL PHOTOTHERAPY SYSTEM
    TRAVIS SIMPKINS; Fiscal Year: 2006
    ..images of the retina and will focus high-energy laser pulses into diffraction-limited spots on the retina for phototherapy/surgery...
  43. REPRODUCTIVE MEDICINE PHOTOTHERAPY
    HENRY SAVAGE; Fiscal Year: 1993
    ..Later, in Phase II, we will propose to characterize the endocrine responses of patients to night lights, and to determine the parameters of illumination which produce the most valuable clinical effects...
  44. DISPERSIVE FIBER OPTICS FOR PDT
    David Putnam; Fiscal Year: 1992
    ..The fibers will have application towards cancer treatment, other related forms of phototherapy, as well as in vivo fiber optic sensing.
  45. Phototherapy of Prostate Cancer-Pro and Anti Apoptosis
    NANCY OLEINICK; Fiscal Year: 2006
    ..abstract_text> ..
  46. PSORALEN-PHOTOTHERAPY OF NORMAL AND PSORIATIC SKIN
    ALVIN ZELICKSON; Fiscal Year: 1980
    ..This project will study: 1) effect on epidermal ultrastructure, and 2) ultrastructural changes in dermal tissue...
  47. Oxygen and Phototherapy in perinatal period: Risk of Acute Lymphoctyic Leukemia
    Nigel Paneth; Fiscal Year: 2008
    ..the relationship of ALL to 3 perinatal interventions: maternal O2 therapy, neonatal O2 therapy, and neonatal phototherapy for jaundice...
  48. LIGHTION THERAPY FOR SEASONAL AFFECTIVE DISOR
    Michael Terman; Fiscal Year: 2003
    ....
  49. MANAGEMENT OF SLEEP-ACTIVITY DISRUPTION IN ALZHEIMERS
    Glenna Dowling; Fiscal Year: 2001
    ..Differences will be determined in the main effects between groups, main effects within groups over time, and the interaction between group and time. Post-hoc contrasts (Tukey) will be performed as needed. ..
  50. FATIGUE, SLEEP AND CIRCADIAN RHYTHMS IN BREAST CANCER
    Sonia Ancoli Israel; Fiscal Year: 2004
    ..Results will provide a scientific basis for future intervention studies, particularly studies with light therapy which can re-synchronize rhythms. ..
  51. Contributions of sleep/rhythms/fatigue to "chemobrain"
    Sonia Ancoli Israel; Fiscal Year: 2009
    ..The reported phenomena of chemobrain will be examined to see if it is related to the complaint of fatigue or sleep disruptions, both of which are known to contribute to decreases in cognitive functioning. ..
  52. Pharmacotherapy for Minor Depression
    Robert Howland; Fiscal Year: 2004
    ..The results of this study will have profound public health implications by improving our understanding of the efficacy of SJW and standard antidepressants for the treatment of MinorD. ..
  53. Melatonin Studies of Totaly Blind Children
    Alfred J Lewy; Fiscal Year: 2010
    ..In a future grant application, we will assess feasibility of a large-scale, multi-center study of melatonin safety and efficacy, which may also be of benefit sighted people with circadian rhythm sleep and mood disorders ..
  54. Phase response curves for home remedies to treat circadian misalignment
    Charmane I Eastman; Fiscal Year: 2010
    ....