withholding treatment

Summary

Summary: Withholding or withdrawal of a particular treatment or treatments, often (but not necessarily) life-prolonging treatment, from a patient or from a research subject as part of a research protocol. The concept is differentiated from REFUSAL TO TREAT, where the emphasis is on the health professional's or health facility's refusal to treat a patient or group of patients when the patient or the patient's representative requests treatment. Withholding of life-prolonging treatment is usually indexed only with EUTHANASIA, PASSIVE, unless the distinction between withholding and withdrawing treatment, or the issue of withholding palliative rather than curative treatment, is discussed.

Top Publications

  1. ncbi Can tyrosine kinase inhibitors be discontinued in patients with metastatic renal cell carcinoma and a complete response to treatment? A multicentre, retrospective analysis
    Manfred Johannsen
    Department of Urology, Charite Universitatsmedizin Berlin, Berlin, Germany
    Eur Urol 55:1430-8. 2009
  2. ncbi Death after withdrawal from dialysis: the most common cause of death in a French dialysis population
    Béatrice Birmelé
    Néphrologie Immunologie Clinique, CHRU Bretonneau, Tours, France
    Nephrol Dial Transplant 19:686-91. 2004
  3. ncbi Extended oral anticoagulant therapy after a first episode of pulmonary embolism
    Giancarlo Agnelli
    Sezione di Medicina Interna e Cardiovascolare, Dipartimento di Medicina Interna, Universita di Perugia, Via Enrico Dal Pozzo, 06123 Perugia, Italy
    Ann Intern Med 139:19-25. 2003
  4. pmc Country, sex, EDSS change and therapy choice independently predict treatment discontinuation in multiple sclerosis and clinically isolated syndrome
    Claire Meyniel
    Department of Neurology, Royal Melbourne Hospital, Victoria, Australia
    PLoS ONE 7:e38661. 2012
  5. ncbi A prospective clinical study in hepatitis B e antigen-negative chronic hepatitis B patients with stringent cessation criteria for adefovir
    Minghao Ha
    Department of Infectious Diseases and Hepatology, Shanghai No 7 hospital, Shanghai 200137, China
    Arch Virol 157:285-90. 2012
  6. ncbi The types of neurological deficits might not justify withholding treatment in patients with low total National Institutes of Health Stroke Scale scores
    Enrique C Leira
    Division of Cerebrovascular Diseases, Department of Neurology, Carver College of Medicine, University of Iowa, Iowa City, IA, USA
    Stroke 43:782-6. 2012
  7. ncbi MRI and withdrawal of life support from newborn infants with hypoxic-ischemic encephalopathy
    Dominic Wilkinson
    Department of Public Health and Primary Health Care, Ethox Centre, University of Oxford, Badenoch Building, Headington, UK
    Pediatrics 126:e451-8. 2010
  8. pmc Treatment interruption in a primary care antiretroviral therapy program in South Africa: cohort analysis of trends and risk factors
    Katharina Kranzer
    The Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, Faculty of Health Science, University of Cape Town, South Africa
    J Acquir Immune Defic Syndr 55:e17-23. 2010
  9. ncbi The risk for fatal pulmonary embolism after discontinuing anticoagulant therapy for venous thromboembolism
    James D Douketis
    McMaster University, Hamilton, Ontario, Canada
    Ann Intern Med 147:766-74. 2007
  10. ncbi Ethical issues in intensive care--a survey among Scandinavian intensivists
    M Tallgren
    Department of Anaesthesia and Intensive Care Medicine, Helsinki University Hospital, Helsinki, Finland
    Acta Anaesthesiol Scand 49:1092-100. 2005

Research Grants

  1. Serpin Modulation of Inflammatory Vasculitis; Potential for Immunomodulatory Ther
    ALEXANDRA ROSE LUCAS; Fiscal Year: 2010
  2. Bifunctional Redox Agent for the Treatment of PPHN
    GARRY JOHN SOUTHAN; Fiscal Year: 2011
  3. A Controlled Trial of CBT for Multiple Sclerosis Inflammation
    David I Daikh; Fiscal Year: 2010
  4. ESTROGEN AND THE AGING BRAIN
    John H Morrison; Fiscal Year: 2013
  5. Individualized Objective Techniques for Early Detection of Ototoxicity
    MARILYN FARNSWORTH contact DILLE; Fiscal Year: 2011
  6. Decision-making for Infants with Complex Life-Threatening Conditions
    Sharron L Docherty; Fiscal Year: 2012
  7. Immunomodulation for Heart Allograft Tolerance
    Richard N Pierson; Fiscal Year: 2013
  8. Gene Discovery for Warfarin-Related Intracerebral Hemorrhage
    Jonathan Rosand; Fiscal Year: 2012
  9. MODULATION OF MULTIDRUG RESISTANCE BY CYCLOSPORIN A
    Charles Erlichman; Fiscal Year: 1992
  10. Expression of anti-HIV siRNA in Blood Cells
    JOHN JOSEPH ROSSI; Fiscal Year: 2013

Detail Information

Publications227 found, 100 shown here

  1. ncbi Can tyrosine kinase inhibitors be discontinued in patients with metastatic renal cell carcinoma and a complete response to treatment? A multicentre, retrospective analysis
    Manfred Johannsen
    Department of Urology, Charite Universitatsmedizin Berlin, Berlin, Germany
    Eur Urol 55:1430-8. 2009
    ....
  2. ncbi Death after withdrawal from dialysis: the most common cause of death in a French dialysis population
    Béatrice Birmelé
    Néphrologie Immunologie Clinique, CHRU Bretonneau, Tours, France
    Nephrol Dial Transplant 19:686-91. 2004
    ..The aim of this retrospective study was to characterize withdrawal from dialysis in a French population cohort...
  3. ncbi Extended oral anticoagulant therapy after a first episode of pulmonary embolism
    Giancarlo Agnelli
    Sezione di Medicina Interna e Cardiovascolare, Dipartimento di Medicina Interna, Universita di Perugia, Via Enrico Dal Pozzo, 06123 Perugia, Italy
    Ann Intern Med 139:19-25. 2003
    ..The optimal duration of oral anticoagulant treatment after a first episode of pulmonary embolism remains uncertain...
  4. pmc Country, sex, EDSS change and therapy choice independently predict treatment discontinuation in multiple sclerosis and clinically isolated syndrome
    Claire Meyniel
    Department of Neurology, Royal Melbourne Hospital, Victoria, Australia
    PLoS ONE 7:e38661. 2012
    ..We conducted a prospective study, MSBASIS, to assess factors leading to first treatment discontinuation in patients with a clinically isolated syndrome (CIS) and early relapsing-remitting multiple sclerosis (RRMS)...
  5. ncbi A prospective clinical study in hepatitis B e antigen-negative chronic hepatitis B patients with stringent cessation criteria for adefovir
    Minghao Ha
    Department of Infectious Diseases and Hepatology, Shanghai No 7 hospital, Shanghai 200137, China
    Arch Virol 157:285-90. 2012
    ..HBsAg seroconversion is the ideal endpoint of adefovir treatment...
  6. ncbi The types of neurological deficits might not justify withholding treatment in patients with low total National Institutes of Health Stroke Scale scores
    Enrique C Leira
    Division of Cerebrovascular Diseases, Department of Neurology, Carver College of Medicine, University of Iowa, Iowa City, IA, USA
    Stroke 43:782-6. 2012
    ....
  7. ncbi MRI and withdrawal of life support from newborn infants with hypoxic-ischemic encephalopathy
    Dominic Wilkinson
    Department of Public Health and Primary Health Care, Ethox Centre, University of Oxford, Badenoch Building, Headington, UK
    Pediatrics 126:e451-8. 2010
    ..There is an urgent need for improved prognostic research into HIE...
  8. pmc Treatment interruption in a primary care antiretroviral therapy program in South Africa: cohort analysis of trends and risk factors
    Katharina Kranzer
    The Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, Faculty of Health Science, University of Cape Town, South Africa
    J Acquir Immune Defic Syndr 55:e17-23. 2010
    ..To investigate antiretroviral treatment (ART) interruption in a long-term treatment cohort in South Africa...
  9. ncbi The risk for fatal pulmonary embolism after discontinuing anticoagulant therapy for venous thromboembolism
    James D Douketis
    McMaster University, Hamilton, Ontario, Canada
    Ann Intern Med 147:766-74. 2007
    ..The long-term risk for fatal pulmonary embolism (PE) after treatment of venous thromboembolism (VTE) may be an important factor in the decision to discontinue this treatment...
  10. ncbi Ethical issues in intensive care--a survey among Scandinavian intensivists
    M Tallgren
    Department of Anaesthesia and Intensive Care Medicine, Helsinki University Hospital, Helsinki, Finland
    Acta Anaesthesiol Scand 49:1092-100. 2005
    ....
  11. pmc Withdrawing may be preferable to withholding
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, Belgium
    Crit Care 9:226-9. 2005
    ..In this article, I will provide arguments why, although the two actions are indeed ethically equivalent, withdrawing life-sustaining therapy may in fact be preferable to withholding...
  12. ncbi Analysis of terminal events in 109 successive deaths in a Belgian intensive care unit
    Kalina Gajewska
    Department of Intensive Care, Erasme University Hospital, Route de Lennik 808, 1070 Brussels, Belgium
    Intensive Care Med 30:1224-7. 2004
    ..To determine the incidence of end-of-life decisions in intensive care unit (ICU) patients...
  13. ncbi Use of feeding tubes in nursing home residents with severe cognitive impairment
    Joan M Teno
    JAMA 287:3211-2. 2002
  14. ncbi Epistaxis as the reason for premature discontinuation of clopidogrel after percutaneous coronary angioplasty with stent implantation
    Edyta Jura-Szołtys
    Department of Laryngology, Silesian Medical University, Katowice, Poland
    Kardiol Pol 69:817-23. 2011
    ..Haemorrhagic complications, including epistaxis, are the main reason for discontinuation of antiplatelet therapy in patients after stent implantation which increases risk of in-stent thrombosis...
  15. ncbi Nurse involvement in end-of-life decision making: the ETHICUS Study
    Julie Benbenishty
    Hadassah Medical Organization, Jerusalem, Israel
    Intensive Care Med 32:129-32. 2006
    ..The purpose was to investigate physicians' perceptions of the role of European intensive care nurses in end-of-life decision making...
  16. ncbi Advance care planning for fatal chronic illness: avoiding commonplace errors and unwarranted suffering
    Joanne Lynn
    Center for Palliative Care Studies, The Washington Home Center for Palliative Care Studies and RAND Health, Washington, DC 20016, USA
    Ann Intern Med 138:812-8. 2003
    ..Reliable improvement will also require making it unacceptable for clinicians to fail to plan ahead for care during fatal chronic illness...
  17. ncbi Reasons, considerations, difficulties and documentation of end-of-life decisions in European intensive care units: the ETHICUS Study
    Charles L Sprung
    Hadassah Hebrew University Medical Center, General Intensive Care Unit, Department of Anesthesiology and Critical Care Medicine, P O Box 12000, 91120 Jerusalem, Israel
    Intensive Care Med 34:271-7. 2008
    ..To evaluate physicians' reasoning, considerations and possible difficulties in end-of-life decision-making for patients in European intensive care units (ICUs)...
  18. ncbi Clinical response in psoriasis patients discontinued from and then reinitiated on etanercept therapy
    Kenneth B Gordon
    Loyola University, Maywood, IL, USA
    J Dermatolog Treat 17:9-17. 2006
    ....
  19. ncbi Patient involvement in decisions to limit treatment: the crucial role of agreement between physician and patient
    Eva C Winkler
    Department of Internal Medicine III, University Hospital Grosshadern, Ludwig Maximilians University, 81377 Munich, Germany
    J Clin Oncol 27:2225-30. 2009
    ....
  20. ncbi Futility and rationing
    N S Jecker
    Department of Medical History and Ethics, University of Washington School of Medicine, Seattle 98195
    Am J Med 92:189-96. 1992
    ..Rationing always occurs against a backdrop of resource scarcity, but futility need not. Toward the end of the paper, we clarify how the various connotations and contexts we associate with each term enhance or frustrate ethical debate...
  21. ncbi Withdrawal of care in Japan
    Kaoruko Aita
    Department of Social Gerontology, School of Health Sciences and Nursing, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Lancet 368:12-4. 2006
  22. ncbi Are terminally ill patients dying in the ICU suitable for non-heart beating organ donation?
    Jean Pierre Revelly
    Surgical Intensive Care Unit, Centre Hospitalier Universitaire Vaudois, 1011, Lausanne, Switzerland
    Intensive Care Med 32:708-12. 2006
    ..To evaluate the feasibility of implementing a program of controlled non-heart beating organ donation, in patients undergoing the withdrawal of intensive care treatment...
  23. ncbi Outcome of patients who have therapy withheld or withdrawn in ICU
    J P Lewis
    Intensive Care Unit, Royal Perth Hospital, Perth, Western Australia, Australia
    Anaesth Intensive Care 35:387-92. 2007
    ..Long-term survival in critically ill patients who had life support limitations was very rare in this ICU...
  24. ncbi Efficacy and safety of atazanavir, with or without ritonavir, as part of once-daily highly active antiretroviral therapy regimens in antiretroviral-naive patients
    D R Malan
    Triple M Research, Port Elizabeth, South Africa
    J Acquir Immune Defic Syndr 47:161-7. 2008
    ..Study AI424-089 was a prospective, randomized, open-label, 96-week study comparing 2 ATV-based treatment regimens in ARV-naive HIV-infected patients...
  25. ncbi The legal framework for end of life care: a United Kingdom perspective
    Dominic Bell
    Intensive Care Anaesthesia, General Infirmary at Leeds, Great George Street, LS1 3EX, Leeds, UK
    Intensive Care Med 33:158-62. 2007
  26. ncbi Reasons for stopping antiretrovirals used in an initial highly active antiretroviral regimen: increased incidence of stopping due to toxicity or patient/physician choice in patients with hepatitis C coinfection
    A Mocroft
    Royal Free Centre for HIV Medicine and Department of Primary Care and Population Sciences, Royal Free and University College Medical School, London, NW3 2PF UK
    AIDS Res Hum Retroviruses 21:743-52. 2005
    ..Managing adverse events must remain a key intervention in maintaining HAART. There is a need for further studies to describe the relationship between HCV, specific antiretrovirals, and different treatment strategies...
  27. ncbi End-of-life decisions: a cohort study of the withdrawal of all active treatment in intensive care units in the United Kingdom
    Hannah Wunsch
    Department of Anesthesiology, Columbia University, New York Presbyterian Hospital, New York, NY 10025, USA
    Intensive Care Med 31:823-31. 2005
    ..To describe the epidemiology of active treatment withdrawal in a nationally representative cohort of intensive care units (ICUs) focusing on between-unit differences...
  28. ncbi Withholding treatment, withdrawing treatment, and palliative care in the neonatal intensive care unit
    Frans J Walther
    Neonatal Center, Department of Pediatrics, Leiden University Medical Center, J6 S, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    Early Hum Dev 81:965-72. 2005
    ..Perinatal audit and after-care of the family complete the process. The Dutch viewpoint and practice guidelines on withholding and withdrawing of neonatal intensive care are presented...
  29. ncbi Discontinuation of postmenopausal hormone therapy
    Deborah Grady
    Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California, USA
    Am J Med 118:163-5. 2005
    ..For women who cannot tolerate even a slow taper, the value of symptom relief likely outweighs any increased risks due to HT use...
  30. ncbi End-of-life decisions in Swedish ICUs. How do physicians from the admitting department reason?
    Mia Svantesson
    Department of Anesthesia and Intensive Care, Centre for Caring Sciences, Orebro University Hospital, SE 701 85 Orebro, Sweden
    Intensive Crit Care Nurs 19:241-51. 2003
    ..To study how physicians from the admitting department reason during the decision-making process to forego life-sustaining treatment of patients in intensive care units (ICUs)...
  31. ncbi The contribution of withholding or withdrawing care to newborn mortality
    Lorayne Barton
    Division of Newborn Medicine, Department of Pediatrics, Keck School of Medicine, University of Southern California, Women s and Children s Hospital, Los Angeles, California, USA
    Pediatrics 116:1487-91. 2005
    ..We sought to determine the contribution of withholding or withdrawing care to neonatal mortality in our hospital over a 10-year period from 1993 through 2002...
  32. ncbi Forgoing life sustaining treatments: differences and similarities between North America and Europe
    N M Moselli
    Unit of Anaesthesiology, Intensive Care and Pain Therapy, Institute for Cancer Research and Treatment IRCC, Candiolo Torino, Italy
    Acta Anaesthesiol Scand 50:1177-86. 2006
    ..The objective of this review is to examine policies and attitudes towards end-of-life decisions in Europe and North America and to outline differences and similarities...
  33. ncbi DNR directives are established early in mechanically ventilated intensive care unit patients
    Tasnim Sinuff
    Department of Medicine, McMaster University Health Sciences Center, Room 2C11, 1200 Main Street West, Hamilton, Ontario L8N 3Z5, Canada
    Can J Anaesth 51:1034-41. 2004
    ..Our objective was to study the rate of establishing do-not-resuscitate (DNR) directives, determinants, and outcomes of those directives for mechanically ventilated patients...
  34. ncbi Parental role in medical decision-making: fact or fiction? A comparative study of ethical dilemmas in French and American neonatal intensive care units
    Kristina Orfali
    MacLean Center for Clinical Medical Ethics, The University of Chicago, 5841 S Maryland Avenue, MC 6098, Chicago, IL 6098, USA
    Soc Sci Med 58:2009-22. 2004
    ..The study provides an analysis of the making of "ethics", with an emphasis on how decisions are conceptualized as ethical dilemmas. The final conclusion is that the ongoing medical authority on ethics remains the key issue...
  35. pmc Decision making and modes of death in a tertiary neonatal unit
    R Roy
    Homerton University Hospital, London E9 6SR, UK
    Arch Dis Child Fetal Neonatal Ed 89:F527-30. 2004
    ..To study the frequency and reason for withdrawal/withholding of life sustaining treatment (LST) and do not resuscitate (DNR) orders in infants who died in a tertiary neonatal unit...
  36. ncbi Legal basis for ethical withholding and withdrawing life-sustaining medical treatment from infants and children
    James Tibballs
    Intensive Care Unit and Department of Paediatrics, Royal Children s Hospital, The University of Melbourne, Melbourne, Victoria, Australia
    J Paediatr Child Health 43:230-6. 2007
    ..These legal principles may facilitate difficult ethical decisions. This article identifies a number of common law cases which establishes these principles...
  37. ncbi Tube feedings and persistent vegetative state patients: ordinary or extraordinary means?
    Peter Clark
    Department of Theology, Saint Joseph s University, 5600 City Avenue, Philadelphia, PA 19135 1395, USA
    Christ Bioeth 12:43-64. 2006
    ..Moreover, additional analysis is needed to determine whether the papal allocution is in conflict with the traditional Catholic medical ethics understanding of the ordinary-extraordinary care distinction...
  38. ncbi Harm and uncertainty in newborn intensive care
    Kenneth Kipnis
    Department of Philosophy, University of Hawaii at Manoa, 2530 Dole Street, Honolulu, HI 96822, USA
    Theor Med Bioeth 28:393-412. 2007
    ..Though treatment may offer a reasonable chance of a good outcome, it is argued that there are situations in which neonatologists should nonetheless defer to parental nontreatment decisions...
  39. ncbi Withdrawing and withholding life support in the intensive care unit: a Spanish prospective multi-centre observational study
    A Esteban
    Hospital Universitario de Getafe, Carretera de Toledo Km 12, 500, Getafe 28905, Madrid, Spain
    Intensive Care Med 27:1744-9. 2001
    ..To determine how frequently life support is withheld or withdrawn from adult critically ill patients, and how physicians and patients families agree on the decision regarding the limitation of life support...
  40. ncbi Flaws in the assessment of the best interests of the newborn
    Carlo V Bellieni
    Department of Pediatrics, Obstetrics and Reproduction Medicine, University of Siena, Italy
    Acta Paediatr 98:613-7. 2009
    ..In most cases, parents' opinions are considered important and are sometimes the main determinant in decision making. However, it is unclear whether parents' decisions are based on their own wishes or on the best interests of the newborn...
  41. ncbi Decisions for life made in the perinatal period: who decides and on which standards?
    Jag Ahluwalia
    Rosie Hospital, Addenbrooke s NHS Trust, Hills Road, Cambridge CB2 0QQ, UK
    Arch Dis Child Fetal Neonatal Ed 93:F332-5. 2008
  42. pmc Racial and ethnic differences in preferences for end-of-life treatment
    Amber E Barnato
    Center for Research on Health Care, University of Pittsburgh, 200 Meyran Avenue, Suite 200, Pittsburgh, PA, 15312, USA
    J Gen Intern Med 24:695-701. 2009
    ..These studies are limited by size, representation, and insufficient exploration of sociocultural covariables...
  43. pmc Functional neuroimaging and withdrawal of life-sustaining treatment from vegetative patients
    D J Wilkinson
    Oxford Uehiro Centre for Practical Ethics, University of Oxford, Oxford, UK
    J Med Ethics 35:508-11. 2009
    ..Although functional neuroimaging is likely to play an increasing role in the assessment of patients in a vegetative state, caution is needed in the interpretation of neuroimaging findings...
  44. ncbi End-of-life decision before and after birth: changing ethical considerations
    Andrew B Pinter
    Department of Paediatrics, University of Pecs, 7623 Pecs, Hungary
    J Pediatr Surg 43:430-6. 2008
    ....
  45. ncbi End-of-life decisions in Dutch neonatal intensive care units
    A A Eduard Verhagen
    Department of Pediatrics, University Medical Centre, 9700 RB Groningen, The Netherlands
    Arch Pediatr Adolesc Med 163:895-901. 2009
    ..To clarify the practice of end-of-life decision making in severely ill newborns...
  46. ncbi The Terri Schiavo case: legal, ethical, and medical perspectives
    Joshua E Perry
    Vanderbilt University, Nashville, Tennessee, USA
    Ann Intern Med 143:744-8. 2005
    ....
  47. ncbi Potential for donation after cardiac death in a children's hospital
    Amy L Durall
    Division of Critical Care, Department of Anesthesia, Perioperative and Pain Medicine, Children s Hospital Boston, 300 Longwood Ave, Boston, MA 02115, USA
    Pediatrics 119:e219-24. 2007
    ..As part of this process, we sought to determine the number of potential kidney donation after cardiac death donors in our PICUs...
  48. ncbi Neonatal end-of-life care: a review of the research literature
    Teresa Moro
    University of Chicago, School of Social Service Administration, IL 60612, USA
    J Perinat Neonatal Nurs 20:262-73. 2006
    ....
  49. pmc Is it in the best interests of an intellectually disabled infant to die?
    D Wilkinson
    Mercy Hospital for Women, PO Box 5027, Heidelberg West, Victoria 3081, Australia
    J Med Ethics 32:454-9. 2006
    ..The best interests of the child can be affected by severe or profound intellectual disability. It is, though, not as clear-cut as some might expect...
  50. ncbi Withholding and withdrawal of life-sustaining treatment in a Lebanese intensive care unit: a prospective observational study
    Alexandre Yazigi
    Department of Anesthesiology and Surgical Intensive Care, Hotel Dieu de France Hospital, Saint Joseph University, Adib Ishac Street, Beirut, Lebanon
    Intensive Care Med 31:562-7. 2005
    ..To evaluate the implementation and process of withholding and withdrawing life-sustaining treatment in an intensive care unit...
  51. ncbi EfCCNa survey: European intensive care nurses' attitudes and beliefs towards end-of-life care
    Jos M Latour
    Clinical Researcher, Paediatric Intensive Care Unit, Erasmus MC Sophia Children s Hospital, Rotterdam, The Netherlands
    Nurs Crit Care 14:110-21. 2009
    ..Few studies have examined the involvement of European intensive care nurses' involvement in EOL care decisions and the extent to which their nursing practice is based on shared beliefs, experiences and attitudes...
  52. pmc Death in the neonatal intensive care unit: changing patterns of end of life care over two decades
    D J Wilkinson
    Department of Neonatology, Royal Children s Hospital, Parkville, Melbourne, Victoria 3052, Australia
    Arch Dis Child Fetal Neonatal Ed 91:F268-71. 2006
    ..Death remains a common event in the neonatal intensive care unit, and often involves limitation or withdrawal of life sustaining treatment...
  53. ncbi Circumstances surrounding end of life in a pediatric intensive care unit
    Daniel Garros
    Department of Critical Care Medicine, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    Pediatrics 112:e371. 2003
    ..Approximately 60% of deaths in pediatric intensive care units follow limitation or withdrawal of life-sustaining treatment (LST). We aimed to describe the circumstances surrounding decision making and end-of-life care in this setting...
  54. ncbi Circumstances surrounding the deaths of hospitalized children: opportunities for pediatric palliative care
    Brian S Carter
    Vanderbilt Children s Hospital, Vanderbilt University School of Medicine, TN, USA
    Pediatrics 114:e361-6. 2004
    ..This study was conducted to describe the circumstances surrounding the deaths of hospitalized terminally ill children, especially pain and symptom management by the multidisciplinary pediatric care team...
  55. ncbi The reason for discontinuation of the first tumor necrosis factor (TNF) blocking agent does not influence the effect of a second TNF blocking agent in patients with rheumatoid arthritis
    Marlies Blom
    Department of Rheumatology, Radboud University Nijmegen Medical Centre, PO Box 9101, H 470, 6500 HB Nijmegen, The Netherlands
    J Rheumatol 36:2171-7. 2009
    ..To investigate whether the reason for discontinuation of the first tumor necrosis factor (TNF) blocking agent influences the effect of a second TNF blocking agent...
  56. ncbi Conflicts about end-of-life decisions in NICUs in the Netherlands
    A A Eduard Verhagen
    Department of Pediatrics, Beatrix Children s Hospital, University Medical Center Groningen, Groningen, Netherlands
    Pediatrics 124:e112-9. 2009
    ..To determine the frequency and background of conflicts about neonatal end-of-life (EoL) decisions...
  57. ncbi End-of-life after birth: death and dying in a neonatal intensive care unit
    Jaideep Singh
    Department of Pediatrics, University of Chicago, and the MacLean Center for Clinical Medical Ethics, Chicago, Illinois 60637, USA
    Pediatrics 114:1620-6. 2004
    ..We hypothesized that clarifying them would more accurately portray the process of end-of-life decision-making in the NICU...
  58. ncbi Noninitiation or withdrawal of intensive care for high-risk newborns
    Edward F Bell
    Pediatrics 119:401-3. 2007
    ....
  59. ncbi Futility: a concept in evolution
    Jeffrey P Burns
    Division of Critical Care Medicine, Department of Anesthesia, Children s Hospital Boston and Harvard Medical School, Boston, MA 02115, USA
    Chest 132:1987-93. 2007
    ....
  60. ncbi Are newborns morally different from older children?
    Annie Janvier
    McGill University, Montreal, Quebec, Canada
    Theor Med Bioeth 28:413-25. 2007
    ....
  61. pmc Terminal sedation: source of a restless ethical debate
    Johannes J M van Delden
    J Med Ethics 33:187-8. 2007
  62. ncbi Discussing withholding and withdrawing of life-sustaining medical treatment in paediatric inpatients: audit of current practice
    Zornitza Stark
    Department of Clinical Quality and Safety, Royal Children s Hospital, Melbourne, Victoria, Australia
    J Paediatr Child Health 44:399-403. 2008
    ....
  63. ncbi The legal framework for end-of-life decisions in the UK
    Janet M Rennie
    UCL Elizabeth Garrett Anderson Institute for Women s Health, University College London Hospitals, London, UK
    Semin Fetal Neonatal Med 13:296-300. 2008
    ..Legal proceedings should be used only as a last resort...
  64. ncbi Withdrawal and limitation of life-sustaining treatments in a paediatric intensive care unit and review of the literature
    Peter Moore
    Orange Base Hospital, Orange, Australia
    J Paediatr Child Health 44:404-8. 2008
    ..To examine withdrawal and limitation of life-sustaining treatment (WLST) in an Australian paediatric intensive care unit (PICU) and to compare this experience with published data from other countries...
  65. ncbi Systematic review: D-dimer to predict recurrent disease after stopping anticoagulant therapy for unprovoked venous thromboembolism
    Madeleine Verhovsek
    McMaster University and St Joseph s Hospital, Hamilton, Ontario, Canada
    Ann Intern Med 149:481-90, W94. 2008
    ..Methods for predicting risk for recurrence may identify low-risk patients who are less likely to benefit from prolonged anticoagulation...
  66. ncbi HIV-1 transmission after cessation of early antiretroviral therapy among men having sex with men
    Philip Rieder
    Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, Zurich, Switzerland
    AIDS 24:1177-83. 2010
    ..To study transmission dynamics during acute infection, during the aviremic phase over the period of early antiretroviral therapy (ART) and during the phase of viral rebound after early treatment was stopped...
  67. ncbi Parental refusal of medical treatment for a newborn
    John J Paris
    Boston College, Chestnut Hill, MA 02167, USA
    Theor Med Bioeth 28:427-41. 2007
    ..We conclude with support for the policy articulated in the 2007 guidelines of the American Academy of Pediatrics on non-intervention or withdrawal of intensive care for high-risk newborns...
  68. ncbi Withdrawal of medical treatment in the ICU. A cohort study of 318 cases during 1994-2000
    T Nolin
    Department of Anaesthesiology, Central Hospital, Kristianstad, Sweden
    Acta Anaesthesiol Scand 47:501-7. 2003
    ..The aim of this study was to determine the incidence of decisions to withdraw medical therapy in a Swedish, general intensive care unit (ICU), the underlying reasons and outcomes...
  69. ncbi Time course of adverse events most commonly associated with topiramate for migraine prevention
    M J A Lainez
    University Clinic Hospital, University of Valencia, Valencia, Spain
    Eur J Neurol 14:900-6. 2007
    ..AEs leading to discontinuation of topiramate are probably to occur during dose titration. If a patient has not experienced one of these AEs within the first 6 weeks of initiating topiramate 100 mg/day, these AEs are unlikely to occur...
  70. ncbi End-of-life practices in the Netherlands under the Euthanasia Act
    Agnes van der Heide
    Department of Public Health, Erasmus Medical Center, Rotterdam, Netherlands
    N Engl J Med 356:1957-65. 2007
    ..In 2005, we performed a follow-up study of euthanasia, physician-assisted suicide, and other end-of-life practices...
  71. ncbi End-of-life practices in 282 intensive care units: data from the SAPS 3 database
    Elie Azoulay
    Service de Reanimation Medicale, Hôpital Saint Louis et Université Paris 7, Assistance Publique, Hopitaux de Paris, Paris, France
    Intensive Care Med 35:623-30. 2009
    ..To report incidence and characteristics of decisions to forgo life-sustaining therapies (DFLSTs) in the 282 ICUs who contributed to the SAPS3 database...
  72. ncbi Practices of anaesthesiologists with regard to withholding and withdrawal of life support from the critically ill in Turkey
    L Iyilikci
    Department of Anaesthesiology, School of Medicine, Dokuz Eylul University, Izmir, Turkey
    Acta Anaesthesiol Scand 48:457-62. 2004
    ..To determine practices of Turkish anaesthesiologists with regard to withholding and withdrawal of life support from the critically ill...
  73. ncbi Evaluation of changes in forgoing life-sustaining treatment in Israeli ICU patients
    Daniel J Jakobson
    Department of Anesthesiology and Critical Care Medicine, Hadassah Hebrew University Medical Center, The Hebrew University of Jerusalem, PO Box 12000, Jerusalem, Israel 91120, USA
    Chest 126:1969-73. 2004
    ..Over the last several years, there have been legal decisions and changes in medical directives concerning end-of-life decisions in Israel...
  74. ncbi Perinatal care at the threshold of viability: an international comparison of practical guidelines for the treatment of extremely preterm births
    Maria Serenella Pignotti
    Neonatal Medicine, A Meyer Children s Hospital, University of Florence, Via Luca Giordano 13, 50132 Firenze, Italy
    Pediatrics 121:e193-8. 2008
    ....
  75. ncbi Usefulness of repeated D-dimer testing after stopping anticoagulation for a first episode of unprovoked venous thromboembolism: the PROLONG II prospective study
    Benilde Cosmi
    Department of Angiology and Blood Coagulation, Marino Golinelli University Hospital St Orsola Malpighi, Bologna, Italy
    Blood 115:481-8. 2010
    ..9; 95% CI: 2.1-30; P = .002). Repeated D-d testing after anticoagulation suspension for a first episode of unprovoked VTE could help tailor the duration of treatment. This trial is registered at http://clinicaltrials.gov as NCT00266045...
  76. pmc Ethical analysis of withdrawing ventricular assist device support
    Paul S Mueller
    Division of General Internal Medicine, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Mayo Clin Proc 85:791-7. 2010
    ..To describe a series of patients with heart failure supported with a ventricular assist device (VAD) who requested (or whose surrogates requested) withdrawal of VAD support and the legal and ethical aspects pertaining to these requests...
  77. ncbi Survey of respiratory therapists' attitudes and concerns regarding terminal extubation
    David C Willms
    Pulmonary Center, Sharp Memorial Hospital, 7901 Frost Street, San Diego CA 92123, USA
    Respir Care 50:1046-9. 2005
    ..There is little published information on the role of respiratory therapists in the process of withdrawal of mechanical ventilatory support...
  78. pmc Within you/without you: biotechnology, ontology, and ethics
    Daniel P Sulmasy
    John J Conley Department of Ethics, St Vincent s Hospital Manhattan, 153 W 11th St, New York, NY, USA
    J Gen Intern Med 23:69-72. 2008
    ....
  79. pmc Ethical and legal views of physicians regarding deactivation of cardiac implantable electrical devices: a quantitative assessment
    Daniel B Kramer
    Cardiovascular Institute, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02446, USA
    Heart Rhythm 7:1537-42. 2010
    ..Despite the high prevalence of pacemakers and implantable cardioverter-defibrillators, little is known about physicians' views surrounding the ethical and legal aspects of managing these devices at the end of life...
  80. pmc Brain damage and the moral significance of consciousness
    Guy Kahane
    University of Oxford, Oxford, UK
    J Med Philos 34:6-26. 2009
    ..We argue that enjoyment of consciousness might actually give stronger moral reasons not to preserve a patient's life and, indeed, that these might be stronger when patients retain significant cognitive function...
  81. ncbi Infliximab continuation rates in patients with rheumatoid arthritis in everyday practice
    Daniel Wendling
    Rheumatology Department, Minjoz Teaching Hospital, CHU Minjoz, 25030 Besancon, France
    Joint Bone Spine 72:309-12. 2005
    ..Infliximab is a major breakthrough in the management of rheumatoid arthritis (RA). We evaluated infliximab continuation rates and reasons for discontinuation in patients with RA...
  82. ncbi Effect of decisions to withhold life support on prolonged survival
    Yen Yuan Chen
    Department of Bioethics, Case Western Reserve University, Cleveland, OH, USA
    Chest 133:1312-8. 2008
    ..We hypothesized that mortality 60 days after ICU admission is not influenced by a decision to withhold use of LST in the context of otherwise providing all indicated care...
  83. ncbi Terri Schiavo--a tragedy compounded
    Timothy E Quill
    Center for Palliative Care and Clinical Ethics at the University of Rochester Medical Center, Rochester, NY, USA
    N Engl J Med 352:1630-3. 2005
  84. pmc Participation of French general practitioners in end-of-life decisions for their hospitalised patients
    E Ferrand
    Service d anesthésie réanimation Samu 94, Hopital Henri Mondor, AP HP 51, Avenue du Marechal de Lattre de Tassigny, 94010 Creteil Cedex, France
    J Med Ethics 32:683-7. 2006
    ....
  85. pmc Assessment of strategies for switching patients from olanzapine to risperidone: a randomized, open-label, rater-blinded study
    Rohan Ganguli
    Western Psychiatric Institute and Clinic, O Hara Street, Pittsburgh, PA 15213 2593, USA
    BMC Med 6:17. 2008
    ..This paper assesses the short-term results of strategies for the discontinuation of olanzapine when initiating risperidone...
  86. ncbi The importance of religious affiliation and culture on end-of-life decisions in European intensive care units
    Charles L Sprung
    General Intensive Care Unit, Department of Anesthesiology and Critical Care Medicine, Medical Center, Hadassah Hebrew University, P O Box 12000, 91120, Jerusalem, Israel
    Intensive Care Med 33:1732-9. 2007
    ..To determine the influence of religious affiliation and culture on end-of-life decisions in European intensive care units (ICUs)...
  87. pmc The impact of regional culture on intensive care end of life decision making: an Israeli perspective from the ETHICUS study
    F D Ganz
    Hadassah Hebrew University School of Nursing, Kiryat Hadassah, PO Box 12000, Jerusalem, Israel
    J Med Ethics 32:196-9. 2006
    ..Several results of the Israeli subsample were different to those of the overall sample...
  88. ncbi Deactivating implanted cardiac devices in terminally ill patients: practices and attitudes
    Paul S Mueller
    Division of General Internal Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    Pacing Clin Electrophysiol 31:560-8. 2008
    ..Clinicians may receive requests to deactivate pacemakers and implantable cardioverter-defibrillators (ICDs) in terminally ill patients...
  89. ncbi Withdrawal of cardiac medications and devices
    Debra Lynn McHale Wiegand
    University of Maryland School of Nursing, USA
    AACN Adv Crit Care 18:415-25. 2007
    ..Critical care nurses support each patient and his or her family and work with other members of the healthcare team to achieve a peaceful death...
  90. ncbi Moral fictions and medical ethics
    Franklin G Miller
    Department of Bioethics, Clinical Center, National Institutes of Health, Bethesda, MD 20892 1156, USA
    Bioethics 24:453-60. 2010
    ..When these moral fictions are exposed, it becomes apparent that conventional medical ethics relating to end-of-life decisions is radically mistaken...
  91. ncbi Physicians' decisions to withhold and withdraw life-sustaining treatment
    Neil J Farber
    Department of Medicine, Christiana Care Health System, Wilmington, Delaware 19899, USA
    Arch Intern Med 166:560-4. 2006
    ..Few data are available about physicians' decisions in regard to withholding or withdrawing life-sustaining measures. We therefore studied internists' views on this subject...
  92. ncbi Interventions to improve care during withdrawal of life-sustaining treatments
    J Randall Curtis
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, School of Medicine, University of Washington, Seattle, Washington 98104 2499, USA
    J Palliat Med 8:S116-31. 2005
    ..Further research is needed to identify and test the most appropriate and responsive outcome measures and to identify the most effective and cost-effective interventions...
  93. ncbi Opioids and benzodiazepines appear paradoxically to delay inevitable death after ventilator withdrawal
    Miles J Edwards
    Center for Ethics in HealthCare, Oregon Health and Science University, Portland, USA
    J Palliat Care 21:299-302. 2005
  94. ncbi Ethics ain't easy: do we need simple rules for complicated ethical decisions?
    Annie Janvier
    Paediatrics, McGill University, Montreal, Quebec, Canada
    Acta Paediatr 97:402-6. 2008
    ..Recommendations from national bodies regarding extremely preterm infants have focussed almost exclusively on thresholds for intervention based upon estimated gestational age (GA) alone...
  95. ncbi 'Death rattle' after withdrawal of mechanical ventilation: practical and ethical considerations
    Erwin J O Kompanje
    Department of Intensive Care and Department of Medical Ethics, Erasmus MC University Medical Center, Room V 208, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    Intensive Crit Care Nurs 22:214-9. 2006
    ..In practice, injectable scopolamine is the reference drug for symptomatic treatment of death rattle...
  96. ncbi Withdrawal of ventilatory support from the dying adult patient
    Lisa Marr
    Medical College of Wisconsin, Palliative Care Center, Division of Neoplastic Diseases and Related Disorders, Milwaukee, WI 53226, USA
    J Support Oncol 2:283-8. 2004
  97. ncbi ICU nurses' preparation of families for death of patients following withdrawal of ventilator support
    Karin T Kirchhoff
    University of Wisconsin, School of Nursing, Madison, WI 53792 2455, USA
    Appl Nurs Res 16:85-92. 2003
    ....
  98. pmc Withdrawing life support and resolution of conflict with families
    Jenny Way
    Department of Medicine, University of Washington, Seattle, WA 98195, USA
    BMJ 325:1342-5. 2002
  99. ncbi Limitation of treatment at the end-of-life: withholding and withdrawal
    Arthur R Derse
    Center for the Study of Bioethics, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226 0509, USA
    Clin Geriatr Med 21:223-38, xi. 2005
    ..The circumstances in which end of life treatment may be ethically and legally limited through withholding or withdrawal are discussed...
  100. ncbi Management of implantable cardioverter defibrillators in end-of-life care
    Nathan E Goldstein
    Robert Wood Johnson Clinical Scholars Program, Yale University School of Medicine, New Haven, Connecticut, USA
    Ann Intern Med 141:835-8. 2004
    ..Implantable cardioverter defibrillators (ICDs) can prevent premature death from an arrhythmia but may also prolong the dying process and make it more distressing...
  101. ncbi The ethics of deactivating implanted cardioverter defibrillators
    Jeffrey T Berger
    State University of New York Stony Brook School of Medicine, USA
    Ann Intern Med 142:631-4. 2005
    ..This paper discusses bioethical considerations in disabling implantable cardioverter defibrillators...

Research Grants63

  1. Serpin Modulation of Inflammatory Vasculitis; Potential for Immunomodulatory Ther
    ALEXANDRA ROSE LUCAS; Fiscal Year: 2010
    ..We have successfully tested one of these serpins, Serp-1, in a small phase 2A clinical trial for anti-inflammatory activity in unstable coronary syndromes (Viron Therapeutics, Inc;proprietary information). ..
  2. Bifunctional Redox Agent for the Treatment of PPHN
    GARRY JOHN SOUTHAN; Fiscal Year: 2011
    ..We now propose to define the value of our technology in a definitive clinically-relevant animal model of PPHN. ..
  3. A Controlled Trial of CBT for Multiple Sclerosis Inflammation
    David I Daikh; Fiscal Year: 2010
    ..We also wilt enhance our understanding of mechanisms by examining potential psychosocial, immune, and endocrine mediators of the relationship betweenSLEs and clinical and neuroimaging markers of MS inflammation. ..
  4. ESTROGEN AND THE AGING BRAIN
    John H Morrison; Fiscal Year: 2013
    ..These results will provide critically important information on brain aging and will aid in the design of hormone treatments that provide maximal neurological benefits for post-menopausal women. ..
  5. Individualized Objective Techniques for Early Detection of Ototoxicity
    MARILYN FARNSWORTH contact DILLE; Fiscal Year: 2011
    ..Further improvements, such as may be accomplished through the combined use of 2f1-f2 and 2f2-f1 DPOAEs or stimulus- frequency otoacoustic emissions, are also desirable for testing patients with greater hearing loss. ..
  6. Decision-making for Infants with Complex Life-Threatening Conditions
    Sharron L Docherty; Fiscal Year: 2012
    ..The goal will be to identify transition points across the trajectory and provide a foundation for developing interventions to facilitate parents'decision-making for these infants. ..
  7. Immunomodulation for Heart Allograft Tolerance
    Richard N Pierson; Fiscal Year: 2013
    ....
  8. Gene Discovery for Warfarin-Related Intracerebral Hemorrhage
    Jonathan Rosand; Fiscal Year: 2012
    ..Thus, even relatively minor elevations in risk for ICH on warfarin can sway the balance in favor of withholding treatment. Accumulated evidence points to a strong familial contribution to ICH susceptibility...
  9. MODULATION OF MULTIDRUG RESISTANCE BY CYCLOSPORIN A
    Charles Erlichman; Fiscal Year: 1992
    ..The proposed studies will evaluate the importance of P-glycoprotein in clinical resistance to MDR and determine whether cyclosporin A can reverse the MDR phenotype in patients...
  10. Expression of anti-HIV siRNA in Blood Cells
    JOHN JOSEPH ROSSI; Fiscal Year: 2013
    ..The long term goal of these studies is the establishment of a method for activation of latent virus followed by selective purging of these cells from infected individuals, ultimately leading to a cure from HIV-1 infection. ..
  11. Role of CTL avidity in epitope variant recognition and immune control of HIV
    Nicole Frahm; Fiscal Year: 2010
    ....
  12. Cocaine behavior: Regulation by k-opioids and serotonin
    Sari Izenwasser; Fiscal Year: 2009
    ..abstract_text> ..
  13. Use of Chronoamperometry to Measure Extracellular 5 HT
    Alan Frazer; Fiscal Year: 2005
    ..These experiments involve multiple approaches to study an effect of specific antidepressant drugs that may be very important in sustaining the enhancement of monoaminergic transmission that underlies clinical improvement ..
  14. Metabolic Polymorphisms and Survival from Brain Tumors
    Melissa Bondy; Fiscal Year: 2004
    ..Thus, patients who can tolerate higher doses of chemotherapy can be treated more efficiently, suffering from less side effects and potentially may have a better outcome. ..
  15. EFFECT OF COCAINE ON ENDOCRINE FUNCTION IN THE RAT
    Catherine Rivier; Fiscal Year: 1992
    ....
  16. An Assessment of a Problem Gambling Self-Change Toolkit
    Richard LaBrie; Fiscal Year: 2007
    ..evaluation studies often places health care providers in the difficult position of deciding between withholding treatment or providing well-intentioned, but unproven treatment...
  17. Immune function in desensitized allograft recipients
    Jonathan Schneck; Fiscal Year: 2005
    ....
  18. Retinoic Acid and Post-pneumonectomy Lung Growth
    CONNIE HSIA; Fiscal Year: 2006
    ..e., the consequences when a natural compensatory response is distorted by pharmacological manipulation that selectively alters some but not all aspects of the natural response. ..
  19. Antiretroviral-TIP for Substance Users
    Sarah Lewis; Fiscal Year: 2005
    ..The reason most often cited by physicians for withholding treatment is active drug involvement...
  20. NOVEL NON-PEPTIDE ANTAGONIST OF THE MCH RECEPTOR
    David Schwarz; Fiscal Year: 2003
    ..Compounds successfully emerging from this process will be further evaluated in acute and chronic feeding paradigms in order to select candidates suitable for clinical trials. ..
  21. PHASE II CLINIAL TRIAL OF NEW CHEMOPREVENTIVE AGENTS - W
    Omer Kucuk; Fiscal Year: 2000
    ..5) To evaluate the safety of zileuton in this cohort. ..
  22. Hospice Intervention for Older Adults With End Stage Renal Disease
    Lewis Cohen; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  23. Improving Physician Skill at Providing End-of-Life Care
    J Curtis; Fiscal Year: 2004
    ..The results will allow investigators and others to develop targeted educational and systemic interventions to improve the quality of this care. ..
  24. Balancing Hope & Truth-Telling for Patients with Ca/COPD
    J Curtis; Fiscal Year: 2005
    ..These strategies will be described and translated into interventions targeting nurses, physicians, and teams who provide care for patients with cancer, COPD, and other life-limiting diseases. ..
  25. Patient-Centered Approach to Advance Care Planning
    KARIN KIRCHHOFF; Fiscal Year: 2006
    ..abstract_text> ..
  26. Family Experience: End of Life for a Family Member with a Chronic Illness
    DEBRA LYNN MCHALE WIEGAND; Fiscal Year: 2009
    ..The results of the study will be published and presented in local and national meetings to health care professionals and others who would benefit from information related to how to help these vulnerable family members. ..
  27. The impact of early antiretroviral therapy on HIV persistence and inflammation
    STEVEN GRANT DEEKS; Fiscal Year: 2010
    ..Our work may also provide important insights in the role of chronic inflammation in driving viral persistence, and hence may lead to the development of novel interventions. ..
  28. OUTCOME MEASURES FOR CLINICAL TRIALS IN STRABISMUS
    Jonathan Holmes; Fiscal Year: 2008
    ..Ultimately this research will result in better quality of life for patients with strabismus. ..
  29. Immunologic Control of Drug-resistant HIV-1
    Steven Deeks; Fiscal Year: 2005
    ..Finally, since we will estimate the relative in vivo thresholds for HIV-mediated immunogenicity and pathogenicity, these studies may also have implications for vaccine development. ..
  30. Treatment Intensification for Drug-Resistant HIV
    Steven Deeks; Fiscal Year: 2004
    ..Funding for the pilot clinical trial has been obtained from other sources; funding is requested in this proposal only for costs associated with the measurements of immunologic response to drug-resistant HIV-1. ..
  31. PATHOGENESIS OF RETINOPATHY OF PREMATURITY
    Jonathan Holmes; Fiscal Year: 2003
    ....
  32. DEVELOPMENTAL REGULATION OF O2 SENSING IN THE LUNG
    David Cornfield; Fiscal Year: 2009
    ..The strategy of modulating BKCa channel subunit expression to enhance pulmonary vasodilation may be more broadly applicable to other vascular diseases. ..
  33. Fetal & Adolescent Nicotine Effects on CNS 5HT Systems
    Theodore Slotkin; Fiscal Year: 2003
    ..abstract_text> ..
  34. Maximizing CBT's Efficacy with Medication & CM
    Kathleen Carroll; Fiscal Year: 2009
    ..Variables assessing theoretical mechanisms of action will be assessed monthly during treatment. ..
  35. Predictors of Immunologic Long-term Non-Progression in Children with HIV
    Jintanat Ananworanich; Fiscal Year: 2010
    ..This will be important in deciding when to treat children with antiretroviral therapy. ..
  36. Familial Intracranial Aneurysm Study II (FIA II)
    JOSEPH PAUL BRODERICK; Fiscal Year: 2010
    ..Finally, we will use bioinformatics, statistical methods, and gene sequencing, to identify specific disease producing mutations and/or high risk haplotypes whose functional relevance will be subsequently explored. ..
  37. Health Behavior Change in Cancer Patients and Families
    Carolyn Rabin; Fiscal Year: 2003
    ..This brief assessment study, therefore, has the potential to shed light on an important area of primary and secondary cancer prevention. ..
  38. Toward Optimal End-of-Life Care in the PICU
    Robert Truog; Fiscal Year: 2010
    ....
  39. PEDIATRIC AIDS CLINICAL TRIALS UNIT
    William Borkowsky; Fiscal Year: 2002
    ..This effort will also be helped by established links to previously funded community resources, our community advisory board, and by our own local General Clinical Research Center. ..
  40. DRUGS AND DEVELOPMENT OF THE ADRENERGIC NERVOUS SYSTEM
    Theodore Slotkin; Fiscal Year: 2003
    ....
  41. INTERACTIONS OF HIV-1GP120 WITH BRAIN CELLS: ROLE OF PAG
    Avindra Nath; Fiscal Year: 2001
    ..The transfected cells will be screened for gp120 binding properties and for gp120-induced changes in intracellular calcium. The role of Pag in viral entry by itself or in conjunction with other HIV-coreceptors will also be determined. ..
  42. TREATMENT OF BEHAVIORAL SYMPTOMS IN ALZHEIMERS DISEASE
    Davangere Devanand; Fiscal Year: 2001
    ..These clinical data will be important in improving the management of AD patients with behavioral complications. ..
  43. TREATMENT OF NEGATIVE SYMPTOMS & COGNITIVE IMPAIRMENTS
    William Carpenter; Fiscal Year: 2003
    ..The study will provide new information on the efficacy of d- cyclosporine and glycine for both persistent primary and secondary negative symptoms and its effect on cognitive functioning. ..
  44. Feasibility and Pilot Efficacy of Flash-heated Breastmilk to Reduce Pediatric HIV
    Caroline Chantry; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  45. MECHANISMS OF CHLORPYRIFOS DEVELOPMENTAL NEUROTOXICITY
    Theodore Slotkin; Fiscal Year: 2004
    ..Molecular mechanisms of developmental neurotoxicity can be determined and linked to eventual alterations in behavioral performance. ..
  46. EDUCATIONAL RESOURCE FOR TUMOR HETEROGENEITY
    Roger Day; Fiscal Year: 2004
    ..Utilization of the Patient Encounter Interface in an ongoing training program for oncology residents, focused on patient management skills. ..
  47. PROSPECTIVE INVESTIGATION OF PULMONARY EMBOLISM DX-II
    Paul Stein; Fiscal Year: 2003
    ..4) The team of investigators is strong, and has collaborated previously in successful research in PE. ..
  48. Inflammation and Immunity in Dilated Cardiomyopathy
    Leslie Cooper; Fiscal Year: 2004
    ..The long-term overall goal of this workshop is to translate advances in molecular and cellular mechanisms of disease into improvements in the diagnosis and treatment of patients with DCM. ..
  49. NEUROLEPTIC-INDUCED MOVEMENT DISORDERS IN OLDER PATIENTS
    Dilip Jeste; Fiscal Year: 2003
    ..We believe that our findings will have major therapeutic implications for the use of antipsychotics, particularly in older patients. ..
  50. COMMUNITY CONTEXT, SEP OPERATIONS, & HIV RISK AMONG IDUs
    Ricky Bluthenthal; Fiscal Year: 2005
    ..abstract_text> ..
  51. End of Life Communication Skills for Oncology Fellows
    Anthony Back; Fiscal Year: 2005
    ..This program will create a formal curriculum for communication skills that could be replicated in many institutions to improve the quality of oncologists-patient communication--and ultimately the quality of cancer care--nationwide. ..
  52. SOCIAL AND ENVIRONMENTAL CONTEXTS OF ADAPTATION
    PETER DITTO; Fiscal Year: 2006
    ..We request funding to support three (3) predoctoral and three (3) postdoctoral trainees in the next project period. ..
  53. PST in Geriatric Depression with Executive Dysfunction
    Patricia Arean; Fiscal Year: 2006
    ..Accordingly, we are well positioned to meet the challenges inherent in this difficult but important area of research. ..
  54. ACTION - A CHF Trial Investigating Outcomes of Exercise
    Gregg Fonarow; Fiscal Year: 2006
    ..The trial will take place over 5 years with an initial 6 months for planning, training, and implementation; 3 years of enrollment; 1 year of follow-up; and 6 months for close out, analysis, and presentation. ..
  55. Functional Mechanisms of Antibody Inhibition of HIV-1
    Marshall Posner; Fiscal Year: 2008
    ..Long-term objectives will be to select constructs from in vitro testing for further testing in non-human primate models of prevention and therapeutics. ..
  56. fMRI Predictor Model for Stroke Locomotor Rehabilitation
    Bruce Dobkin; Fiscal Year: 2008
    ..The study is a step toward using fMRI as a tool to develop theory- and evidencebased practices that lessen disabilities after stroke. [unreadable] [unreadable] [unreadable]..
  57. ICU CULTURE AND PROBLEMATIC TREATMENT LIMITATION CASES
    JUDITH BAGGS; Fiscal Year: 2002
    ..With a description of such barriers and facilitators, it will be possible to design interventions to serve patients' interests and be mutually acceptable to patients, families, and health care providers. ..
  58. Improving memory after hippocampal cell loss
    MARK BARDGETT; Fiscal Year: 2007
    ..The results may shed light on new directions in the treatment of memory disorders, and the proposed work will also enhance education in biomedical research among college undergraduates in Kentucky. [unreadable] [unreadable] [unreadable]..
  59. Preschool Vision Screening in Primary Care Settings
    Alex Kemper; Fiscal Year: 2007
    ....
  60. Risk and Predictors of Postpartum Depression
    Lee Cohen; Fiscal Year: 2007
    ..AItshuler, Dr. Hendrick), and the Emory Women's Mental Health Program at Emory University School of Medicine (Dr. Stowe). [unreadable] [unreadable]..
  61. The Obese Critical III: Process and Outcome Disparities
    James O Brien; Fiscal Year: 2008
    ..These studies will describe the effect of excess body weight on critical illness and produce a new type of independent investigator - the ICU health services researcher. ..
  62. MECHANISMS OF CUTANEOUS INJURY IN LUPUS ERYTHEMATOSUS
    Richard Sontheimer; Fiscal Year: 2001
    ....
  63. Mechanisms of Innate and Adaptive Immunity In HCV
    David Nelson; Fiscal Year: 2009
    ..A better understanding of the immunologic factors that determine resolution or persistence of the infection may help in the design of therapies and vaccines for the control of HCV infection. ..