intensive care

Summary

Summary: Advanced and highly specialized care provided to medical or surgical patients whose conditions are life-threatening and require comprehensive care and constant monitoring. It is usually administered in specially equipped units of a health care facility.

Top Publications

  1. doi Hydroxyethyl starch or saline for fluid resuscitation in intensive care
    John A Myburgh
    Division of Critical Care and Trauma, George Institute For Global Health, Sydney, NSW, Australia
    N Engl J Med 367:1901-11. 2012
  2. pmc Development and validation of PRE-DELIRIC (PREdiction of DELIRium in ICu patients) delirium prediction model for intensive care patients: observational multicentre study
    M van den Boogaard
    Department of Intensive Care Medicine, Radboud University Nijmegen Medical Centre, 6500HB Nijmegen, Netherlands
    BMJ 344:e420. 2012
  3. ncbi ESPEN Guidelines on Enteral Nutrition: Intensive care
    K G Kreymann
    Department of Intensive Care Medicine, University Hospital Eppendorf, Hamburg, Germany
    Clin Nutr 25:210-23. 2006
  4. pmc Persistent inflammation and immunosuppression: a common syndrome and new horizon for surgical intensive care
    Lori F Gentile
    Department of Surgery, University of Florida College of Medicine, Gainesville, Florida 32610, USA
    J Trauma Acute Care Surg 72:1491-501. 2012
  5. doi ESPEN Guidelines on Parenteral Nutrition: intensive care
    Pierre Singer
    General Intensive Care Department and Institute for Nutrition Research, Rabin Medical Center, Beilinson Hospital, Tikva, Israel
    Clin Nutr 28:387-400. 2009
  6. pmc Intensive care adult patients with severe respiratory failure caused by Influenza A (H1N1)v in Spain
    Jordi Rello
    Critical Care Department, Joan XXIII University Hospital, CIBERes Enfermedades Respiratorias, IISPV, Mallafre Guasch 4, 43007 Tarragona, Spain
    Crit Care 13:R148. 2009
  7. doi Intensive care of the patient with cirrhosis
    Jody C Olson
    Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN 55905, USA
    Hepatology 54:1864-72. 2011
  8. doi Nitrate-nitrite-nitric oxide pathway: implications for anesthesiology and intensive care
    Eddie Weitzberg
    Section of Anesthesiology and Intensive Care, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
    Anesthesiology 113:1460-75. 2010
  9. pmc Transfusion-related acute lung injury in the critically ill: prospective nested case-control study
    Ognjen Gajic
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Am J Respir Crit Care Med 176:886-91. 2007
  10. pmc Impact of a statewide intensive care unit quality improvement initiative on hospital mortality and length of stay: retrospective comparative analysis
    Allison Lipitz-Snyderman
    Department of Health Policy and Management, Johns Hopkins Bloomberg School of Public Health, 624 N Broadway, Baltimore, MD 21205, USA
    BMJ 342:d219. 2011

Detail Information

Publications382 found, 100 shown here

  1. doi Hydroxyethyl starch or saline for fluid resuscitation in intensive care
    John A Myburgh
    Division of Critical Care and Trauma, George Institute For Global Health, Sydney, NSW, Australia
    N Engl J Med 367:1901-11. 2012
    ..The safety and efficacy of hydroxyethyl starch (HES) for fluid resuscitation have not been fully evaluated, and adverse effects of HES on survival and renal function have been reported...
  2. pmc Development and validation of PRE-DELIRIC (PREdiction of DELIRium in ICu patients) delirium prediction model for intensive care patients: observational multicentre study
    M van den Boogaard
    Department of Intensive Care Medicine, Radboud University Nijmegen Medical Centre, 6500HB Nijmegen, Netherlands
    BMJ 344:e420. 2012
    To develop and validate a delirium prediction model for adult intensive care patients and determine its additional value compared with prediction by caregivers.
  3. ncbi ESPEN Guidelines on Enteral Nutrition: Intensive care
    K G Kreymann
    Department of Intensive Care Medicine, University Hospital Eppendorf, Hamburg, Germany
    Clin Nutr 25:210-23. 2006
    ..There is no general indication for immune-modulating formulae in patients with severe illness or sepsis and an APACHE II Score >15. Glutamine should be supplemented in patients suffering from burns or trauma...
  4. pmc Persistent inflammation and immunosuppression: a common syndrome and new horizon for surgical intensive care
    Lori F Gentile
    Department of Surgery, University of Florida College of Medicine, Gainesville, Florida 32610, USA
    J Trauma Acute Care Surg 72:1491-501. 2012
    Surgical intensive care unit (ICU) stay of longer than 10 days is often described by the experienced intensivist as a "complicated clinical course" and is frequently attributed to persistent immune dysfunction...
  5. doi ESPEN Guidelines on Parenteral Nutrition: intensive care
    Pierre Singer
    General Intensive Care Department and Institute for Nutrition Research, Rabin Medical Center, Beilinson Hospital, Tikva, Israel
    Clin Nutr 28:387-400. 2009
    Nutritional support in the intensive care setting represents a challenge but it is fortunate that its delivery and monitoring can be followed closely...
  6. pmc Intensive care adult patients with severe respiratory failure caused by Influenza A (H1N1)v in Spain
    Jordi Rello
    Critical Care Department, Joan XXIII University Hospital, CIBERes Enfermedades Respiratorias, IISPV, Mallafre Guasch 4, 43007 Tarragona, Spain
    Crit Care 13:R148. 2009
    ..We describe the clinical and epidemiologic characteristics of the first 32 persons reported to be admitted to the intensive care unit (ICU) due to influenza A (H1N1)v infection in Spain.
  7. doi Intensive care of the patient with cirrhosis
    Jody C Olson
    Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN 55905, USA
    Hepatology 54:1864-72. 2011
    Acute deterioration of patients with cirrhosis manifests as multiple organ failure requiring admission to an intensive care unit...
  8. doi Nitrate-nitrite-nitric oxide pathway: implications for anesthesiology and intensive care
    Eddie Weitzberg
    Section of Anesthesiology and Intensive Care, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
    Anesthesiology 113:1460-75. 2010
    ..nitric oxide is involved in numerous physiologic and pathophysiological events important in anesthesiology and intensive care. Nitric oxide is endogenously generated from the amino acid l-arginine and molecular oxygen in reactions ..
  9. pmc Transfusion-related acute lung injury in the critically ill: prospective nested case-control study
    Ognjen Gajic
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Am J Respir Crit Care Med 176:886-91. 2007
    ..Several transfusion characteristics have been postulated as risk factors for TRALI, but the evidence is limited to retrospective studies...
  10. pmc Impact of a statewide intensive care unit quality improvement initiative on hospital mortality and length of stay: retrospective comparative analysis
    Allison Lipitz-Snyderman
    Department of Health Policy and Management, Johns Hopkins Bloomberg School of Public Health, 624 N Broadway, Baltimore, MD 21205, USA
    BMJ 342:d219. 2011
    ..ICU project, a comprehensive statewide quality improvement initiative focused on reduction of infections, was associated with reductions in hospital mortality and length of stay for adults aged 65 or more admitted to intensive care units.
  11. ncbi Critically ill patients readmitted to intensive care units--lessons to learn?
    Philipp G H Metnitz
    Département Réanimation Médicale, Hopital St Louis, Universite Paris VII, Paris, France
    Intensive Care Med 29:241-8. 2003
    To evaluate risk factors in critically ill patients who were readmitted to an intensive care unit (ICU) during their hospital stay.
  12. ncbi Increased mortality associated with after-hours and weekend admission to the intensive care unit: a retrospective analysis
    Deepak Bhonagiri
    Liverpool Hospital, Sydney, NSW, Australia
    Med J Aust 194:287-92. 2011
    To study variation in mortality associated with time and day of admission to the intensive care unit (ICU).
  13. doi Macroscopic postmortem findings in 235 surgical intensive care patients with sepsis
    Christian Torgersen
    Department of Anesthesiology and Critical Care Medicine, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria
    Anesth Analg 108:1841-7. 2009
    ..In this retrospective cohort study, we reviewed macroscopic postmortem examinations of surgical intensive care unit (ICU) patients who died from sepsis or septic shock.
  14. pmc Gastrointestinal function in intensive care patients: terminology, definitions and management. Recommendations of the ESICM Working Group on Abdominal Problems
    Annika Reintam Blaser
    Clinic of Anaesthesiology and Intensive Care, University of Tartu, Puusepa 8, 51014 Tartu, Estonia
    Intensive Care Med 38:384-94. 2012
    ..An international working group convened to standardize the definitions for acute GI failure and GI symptoms and to review the therapeutic options...
  15. ncbi Biomarkers of acute kidney injury in anesthesia, intensive care and major surgery: from the bench to clinical research to clinical practice
    E Moore
    Department of Epidemiology and Preventive Medicine, Australian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, Australia
    Minerva Anestesiol 76:425-40. 2010
    ..It is associated with increased mortality, greater cost, and prolonged Intensive Care Unit (ICU) and hospital stay, despite attempts to develop therapies to prevent or attenuate AKI, which have ..
  16. doi Early lactate-guided therapy in intensive care unit patients: a multicenter, open-label, randomized controlled trial
    Tim C Jansen
    Department of Intensive Care, Erasmus MC University Medical Centre, Rotterdam, The Netherlands
    Am J Respir Crit Care Med 182:752-61. 2010
    ..It is unknown whether lactate monitoring aimed to decrease levels during initial treatment in critically ill patients improves outcome...
  17. pmc Readmission to a surgical intensive care unit: incidence, outcome and risk factors
    Axel Kaben
    Department of Anesthesiology and Intensive Care, Friedrich Schiller University Hospital, Erlanger Allee 101, Jena, 07743, Germany
    Crit Care 12:R123. 2008
    We investigated the incidence of, outcome from and possible risk factors for readmission to the surgical intensive care unit (ICU) at Friedrich Schiller University Hospital, Jena, Germany.
  18. doi Hospital discharge data can be used for monitoring procedures and intensive care related to severe maternal morbidity
    Anne A Chantry
    INSERM, UMR S953, Epidemiological Research on Perinatal Health and Women s and Children s Health, F 75020, Paris, France
    J Clin Epidemiol 64:1014-22. 2011
    ..To estimate the accuracy and reliability of the reporting of diagnoses and procedures related to severe acute maternal morbidity in French hospital discharge data...
  19. pmc Current recognition and management of intra-abdominal hypertension and abdominal compartment syndrome among tertiary Chinese intensive care physicians
    Jian cang Zhou
    Department of Critical Care Medicine, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, China
    J Zhejiang Univ Sci B 12:156-62. 2011
    ..and clinical management of intra-abdominal hypertension (IAH)/abdominal compartment syndrome (ACS) among intensive care physicians in tertiary Chinese hospitals...
  20. ncbi Sensitivity and specificity of a screening test to document traumatic experiences and to diagnose post-traumatic stress disorder in ARDS patients after intensive care treatment
    C Stoll
    Dept of Anaesthesiology, Klinikum Grosshadern, Ludwig Maximilians University, Munich, Germany
    Intensive Care Med 25:697-704. 1999
    Many survivors of critical illness and intensive care unit (ICU) treatment have traumatic memories such as nightmares, panic or pain which can be associated with the development of posttraumatic stress disorder (PTSD)...
  21. doi Fluid resuscitation in septic shock: a positive fluid balance and elevated central venous pressure are associated with increased mortality
    John H Boyd
    University of British Columbia Critical Care Research Laboratories, Heart Lung Institute, St Paul s Hospital, Vancouver, British Columbia, Canada
    Crit Care Med 39:259-65. 2011
    ..To determine whether central venous pressure and fluid balance after resuscitation for septic shock are associated with mortality...
  22. doi Emergency management of children with severe sepsis in the United Kingdom: the results of the Paediatric Intensive Care Society sepsis audit
    D P Inwald
    Department of Paediatrics, Faculty of Medicine, Imperial College London, London, UK
    Arch Dis Child 94:348-53. 2009
    ..To audit current UK practice of the management of severe sepsis in children against the 2002 American College of Critical Care Medicine/Pediatric Advanced Life Support (ACCM-PALS) guideline...
  23. ncbi Effect of obesity on intensive care morbidity and mortality: a meta-analysis
    Morohunfolu E Akinnusi
    Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Western New York Respiratory Research Center, University at Buffalo School of Medicine and Biomedical Sciences, Buffalo, NY, USA
    Crit Care Med 36:151-8. 2008
    To evaluate the effect of obesity on intensive care unit mortality, duration of mechanical ventilation, and intensive care unit length of stay among critically ill medical and surgical patients.
  24. ncbi Eliminating catheter-related bloodstream infections in the intensive care unit
    Sean M Berenholtz
    Departments of Anesthesiology CCM and Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Crit Care Med 32:2014-20. 2004
    ..To determine whether a multifaceted systems intervention would eliminate catheter-related bloodstream infections (CR-BSIs)...
  25. doi Scoring systems for prediction of mortality in patients with intensive care unit-acquired sepsis: a comparison of the Pitt bacteremia score and the Acute Physiology and Chronic Health Evaluation II scoring systems
    Ji Young Rhee
    Division of Infectious Diseases, Department of Medicine, Dankook University, Cheonan, Chungcheongnam do, Republic of Korea
    Shock 31:146-50. 2009
    ..Physiology and Chronic Health Evaluation II (APACHE II) scoring systems for the prediction of mortality in intensive care unit (ICU) patients with sepsis using the retrospective observational method on 134 patients with ICU-acquired ..
  26. pmc Errors in administration of parenteral drugs in intensive care units: multinational prospective study
    Andreas Valentin
    Department of Emergency Medicine, Medical University of Vienna, Vienna, Austria
    BMJ 338:b814. 2009
    To assess on a multinational level the frequency, characteristics, contributing factors, and preventive measures of administration errors in parenteral medication in intensive care units.
  27. doi Extravascular lung water indexed to predicted body weight is a novel predictor of intensive care unit mortality in patients with acute lung injury
    Thelma R Craig
    Regional Intensive Care Unit, Royal Victoria Hospital, Belfast, UK
    Crit Care Med 38:114-20. 2010
    ..Because lung size is dependent on height rather than weight, we hypothesized indexing to predicted body weight may be a better predictor of mortality in acute lung injury/acute respiratory distress syndrome...
  28. doi Acute kidney injury in the intensive care unit: an update and primer for the intensivist
    Paula Dennen
    Divisions of Nephrology and Critical Care Medicine, Denver Health Medical Center and University of Colorado, Denver, CO, USA
    Crit Care Med 38:261-75. 2010
    ..with recent advances in definitions, diagnosis, prevention, and management of acute kidney injury in the intensive care unit...
  29. ncbi Predicting fluid responsiveness in ICU patients: a critical analysis of the evidence
    Frederic Michard
    Medical ICU, CHU de Bicetre, Assistance Publique Hopitaux de Paris, Le Kremlin Bicetre, Universite Paris XI, France
    Chest 121:2000-8. 2002
    ..To identify and critically review the published peer-reviewed, English-language studies investigating predictive factors of fluid responsiveness in ICU patients...
  30. doi Serial measurement of Therapeutic Intervention Scoring System-28 (TISS-28) in a surgical intensive care unit
    Norman Muehler
    Department of Anesthesiology and Intensive Care, Friedrich Schiller University Hospital, Jena 07743, Germany
    J Crit Care 25:620-7. 2010
    ..aim of the study was to assess the use of the Therapeutic Intervention Scoring System-28 (TISS-28) in surgical intensive care unit (ICU) patients and the relationship of the score to the type of surgery, severity of illness, and outcome ..
  31. pmc Multiparameter Intelligent Monitoring in Intensive Care II: a public-access intensive care unit database
    Mohammed Saeed
    Massachusetts Institute of Technology, Cambridge, MA, USA
    Crit Care Med 39:952-60. 2011
    We sought to develop an intensive care unit research database applying automated techniques to aggregate high-resolution diagnostic and therapeutic data from a large, diverse population of adult intensive care unit patients...
  32. pmc Diastolic dysfunction and mortality in severe sepsis and septic shock
    Giora Landesberg
    Department of Anesthesiology and Critical Care Medicine, Hadassah Hebrew University Medical Center, Jerusalem 91120, Israel
    Eur Heart J 33:895-903. 2012
    ..In contrast, diastolic dysfunction is often ignored and its role in determining early mortality from sepsis has not been adequately investigated...
  33. doi Automated drug dispensing system reduces medication errors in an intensive care setting
    Claire Chapuis
    Pharmacy Department, Grenoble University Hospital, France
    Crit Care Med 38:2275-81. 2010
    ..dispensing system on the incidence of medication errors related to picking, preparation, and administration of drugs in a medical intensive care unit. We also evaluated the clinical significance of such errors and user satisfaction.
  34. doi Relationship of a common polymorphism of the glucocorticoid receptor gene to traumatic memories and posttraumatic stress disorder in patients after intensive care therapy
    Daniela Hauer
    Departments of Anaesthesiology, Ludwig Maximilians University, Munich, Germany
    Crit Care Med 39:643-50. 2011
    ..of the BclI polymorphism with plasma cortisol levels, traumatic memories, posttraumatic stress disorder symptoms, and health-related quality of life outcomes in 126 patients undergoing cardiac surgery and intensive care unit therapy.
  35. ncbi Health-related quality of life and post-traumatic stress disorder in patients after cardiac surgery and intensive care treatment
    C Stoll
    Departments of Anaesthesiology, Cardiac Surgery, and Psychiatry, Ludwig Maximilians University, Munich, Germany
    J Thorac Cardiovasc Surg 120:505-12. 2000
    ....
  36. ncbi Sedation and analgesia in German intensive care units: how is it done in reality? Results of a patient-based survey of analgesia and sedation
    JORG MARTIN
    Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, Hospital am Eichert, Eichertstrasse 3, 73035 Göppingen, Germany
    Intensive Care Med 32:1137-42. 2006
    This study carried out the first patient-oriented survey on the practice of analgesia and sedation in German intensive care units, examining whether the goals of early spontaneous breathing and awake, cooperative patients are achieved.
  37. doi Differences in organ dysfunction in endotoxin-tolerant pigs under intensive care exposed to a second hit of endotoxin
    Markus Castegren
    Centre for Clinical Research Sörmland, Uppsala University, Eskilstuna, Sweden
    Shock 37:501-10. 2012
    ..the effect of endotoxin tolerance on organ dysfunction, and therefore, this was investigated in a porcine intensive care sepsis model. Twenty-seven healthy pigs, including nine control animals, were included in the study...
  38. doi Provision of protein and energy in relation to measured requirements in intensive care patients
    Matilde Jo Allingstrup
    Department of Intensive Care 4131, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Clin Nutr 31:462-8. 2012
    Adequacy of nutritional support in intensive care patients is still a matter of investigation. This study aimed to relate mortality to provision, measured requirements and balances for energy and protein in ICU patients.
  39. doi I-SAVE study: impact of sedation, analgesia, and delirium protocols evaluated in the intensive care unit: an economic evaluation
    Don Kelena Awissi
    Pharmacy Department, Maisonneuve Rosemont Hospital, Montreal, Quebec, Canada
    Ann Pharmacother 46:21-8. 2012
    b>Intensive care units (ICUs) account for considerable health care costs. Adequate pain and sedation management is important to clinical care.
  40. doi Outcomes of critically ill patients with acute kidney injury and end-stage renal disease requiring renal replacement therapy: a case-control study
    Eduardo Rocha
    Department of Nephrology, Faculdade de Medicina, Universidade Federal do Rio de Janeiro, Brazil
    Nephrol Dial Transplant 24:1925-30. 2009
    ..This study aimed to evaluate and compare the characteristics and outcomes of patients with end-stage renal disease (ESRD) with those of matched controls of patients with acute kidney injury (AKI) requiring renal replacement therapy...
  41. doi Pain assessment is associated with decreased duration of mechanical ventilation in the intensive care unit: a post Hoc analysis of the DOLOREA study
    Jean Francois Payen
    Department of Anesthesiology and Critical Care, Grenoble University Hospital, Grenoble, France
    Anesthesiology 111:1308-16. 2009
    ..Critically ill patients frequently experience pain, but assessment rates remain below 40% in mechanically ventilated patients. Whether pain assessment affects patient outcomes is largely unknown...
  42. ncbi Continuous versus intermittent infusion of temocillin, a directed spectrum penicillin for intensive care patients with nosocomial pneumonia: stability, compatibility, population pharmacokinetic studies and breakpoint selection
    Raf De Jongh
    Dienst Voor Intensieve Zorgen, Ziekenhuis Oost Limburg, B 3600 Genk, Belgium
    J Antimicrob Chemother 61:382-8. 2008
    ..We aimed at documenting its potential clinical usefulness in intensive care (IC) patients using pharmacokinetic/pharmacodynamic approaches applied to conventional (twice daily) and ..
  43. doi Risk factors for severe complications of the novel influenza A (H1N1): analysis of patients hospitalized in Italy
    M Bassetti
    Infectious Diseases Division, San Martino Hospital and University of Genoa School of Medicine, Genoa, Italy
    Clin Microbiol Infect 17:247-50. 2011
    ..Fifty percent of them had pneumonia, 12% were admitted to the intensive care unit and 3% died. Antiviral treatment was initiated in 75% of patients started within 48 h...
  44. ncbi Impact of HAART advent on admission patterns and survival in HIV-infected patients admitted to an intensive care unit
    Enrique Casalino
    Infectious Diseases Intensive Care Unit and the Epidemiology and Biostatistics Department, Bichat Claude Bernard University Hospital, Paris, France
    AIDS 18:1429-33. 2004
    ..Several studies found increased survival times and decreased hospitalization rates since the introduction of highly active antiretroviral therapy (HAART)...
  45. ncbi Inadequate antimicrobial treatment of infections: a risk factor for hospital mortality among critically ill patients
    M H Kollef
    Department of Internal Medicine, Washington University School of Medicine, St Louis, MO, USA
    Chest 115:462-74. 1999
    ..To evaluate the relationship between inadequate antimicrobial treatment of infections (both community-acquired and nosocomial infections) and hospital mortality for patients requiring ICU admission...
  46. ncbi Transthoracic echocardiography for cardiopulmonary monitoring in intensive care
    M B Jensen
    Aarhus University Hospital, Department of Anaesthesiology and Intensive Care, Skejby Sygehus, Denmark
    Eur J Anaesthesiol 21:700-7. 2004
    ..To evaluate the feasibility of an abbreviated focus assessed transthoracic echocardiographic protocol, consisting of four standardized acoustic views for cardiopulmonary screening and monitoring...
  47. doi EfCCNa survey: European intensive care nurses' attitudes and beliefs towards end-of-life care
    Jos M Latour
    Clinical Researcher, Paediatric Intensive Care Unit, Erasmus MC Sophia Children s Hospital, Rotterdam, The Netherlands
    Nurs Crit Care 14:110-21. 2009
    ..Few studies have examined the involvement of European intensive care nurses' involvement in EOL care decisions and the extent to which their nursing practice is based on shared ..
  48. ncbi Delirium and its motoric subtypes: a study of 614 critically ill patients
    Josh F Peterson
    Division of General Internal Medicine, Center for Health Services Research, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    J Am Geriatr Soc 54:479-84. 2006
    ..To describe the motoric subtypes of delirium in critically ill patients and compare patients aged 65 and older with a younger cohort...
  49. doi Treating hyperglycemia improves skeletal muscle protein metabolism in cancer patients after major surgery
    Gianni Biolo
    Division of Internal Medicine, Department of Clinical, Morphological and Technological Sciences, University of Trieste, Trieste, Italy
    Crit Care Med 36:1768-75. 2008
    ..We compared the effects of insulin-mediated euglycemia and moderate hyperglycemia on kinetics of protein and selected amino acids in skeletal muscle of female cancer patients after major surgery...
  50. ncbi The functional outcome and quality of life of children after admission to an intensive care unit
    Anna Taylor
    Intensive Care Unit, Royal Children s Hospital, Flemington Road, Victoria 3052, Parkville, Australia
    Intensive Care Med 29:795-800. 2003
    To evaluate the long-term outcome of children following admission to a paediatric intensive care unit.
  51. pmc Prevention, diagnosis, therapy and follow-up care of sepsis: 1st revision of S-2k guidelines of the German Sepsis Society (Deutsche Sepsis-Gesellschaft e.V. (DSG)) and the German Interdisciplinary Association of Intensive Care and Emergency Medicine (Deut
    K Reinhart
    University Hospital Jena, Clinic for Anaesthesiology and Intensive Care Therapy, Jena, Germany
    Ger Med Sci 8:Doc14. 2010
    ....
  52. ncbi Cerebral microdialysis: research technique or clinical tool
    M M Tisdall
    Department of Neuroanaesthesia and Neurocritical Care, The National Hospital for Neurology and Neurosurgery Queen Square, London WC1N 3BG, UK
    Br J Anaesth 97:18-25. 2006
    ..Microdialysis has the potential to become an established part of mainstream multi-modality monitoring during the management of acute brain injury but at present should be considered a research tool for use in specialist centres...
  53. ncbi Risk factors, sequential organ failure assessment and model for end-stage liver disease scores for predicting short term mortality in cirrhotic patients admitted to intensive care unit
    E Cholongitas
    Liver Transplantation and Hepatobiliary Medicine Unit, Royal Free Hospital, London, UK
    Aliment Pharmacol Ther 23:883-93. 2006
    Prognostic scores in an intensive care unit (ICU) evaluate outcomes, but derive from cohorts containing few cirrhotic patients.
  54. doi Procalcitonin (PCT)-guided algorithm reduces length of antibiotic treatment in surgical intensive care patients with severe sepsis: results of a prospective randomized study
    S Schroeder
    Interdisciplinary Intensive Care Unit, Department of Anaesthesiology and Intensive Care Medicine, Westküstenklinikum, Heide, Germany
    Langenbecks Arch Surg 394:221-6. 2009
    Adequate indication and duration of administration are central issues of modern antibiotic treatment in intensive care medicine...
  55. doi Assessing and improving safety climate in a large cohort of intensive care units
    J Bryan Sexton
    Department of Psychiatry, Duke University Health System, Durham, NC, USA
    Crit Care Med 39:934-9. 2011
    To evaluate the impact of a comprehensive unit-based safety program on safety climate in a large cohort of intensive care units participating in the Keystone intensive care unit project.
  56. doi Procalcitonin for reduced antibiotic exposure in the critical care setting: a systematic review and an economic evaluation
    Daren K Heyland
    Department of Medicine, Queen s University, Kingston, Ontario, Canada
    Crit Care Med 39:1792-9. 2011
    ..The purpose of this analysis was to evaluate the effect of a procalcitonin-guided antibiotic strategy on clinical and economic outcomes...
  57. pmc Randomized trial of initial trophic versus full-energy enteral nutrition in mechanically ventilated patients with acute respiratory failure
    Todd W Rice
    Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA
    Crit Care Med 39:967-74. 2011
    ..e., trophic) enteral nutrition would decrease episodes of gastrointestinal intolerance/complications and improve outcomes as compared to initial full-energy enteral nutrition in patients with acute respiratory failure...
  58. doi Pandemic H1N1 in children requiring intensive care in Australia and New Zealand during winter 2009
    Michael Yung
    Intensive Care Unit, Women s and Children s Hospital, Adelaide, Australia
    Pediatrics 127:e156-63. 2011
    To describe in detail the pediatric intensive care experience of influenza A, particularly pandemic H1N1-09, in Australia and New Zealand during the 2009 Southern Hemisphere winter and to compare the pediatric experience with that of ..
  59. doi Randomized trial of light versus deep sedation on mental health after critical illness
    Miriam M Treggiari
    University of Washington, Seattle, WA, USA
    Crit Care Med 37:2527-34. 2009
    ..Symptoms of posttraumatic stress disorder are common in patients after they have undergone prolonged mechanical ventilation and are associated with sedation depth...
  60. ncbi A review and analysis of intensive care medicine in the least developed countries
    Martin W Dunser
    Division of General and Surgical Intensive Care Medicine, Department of Anesthesiology and Critical Care Medicine, Innsbruck Medical University, Austria
    Crit Care Med 34:1234-42. 2006
    To give critical care clinicians in Western nations a general overview of intensive care medicine in less developed countries and to stimulate institutional or personal initiatives to improve critical care services in the least developed ..
  61. doi Propensity scores in intensive care and anaesthesiology literature: a systematic review
    Etienne Gayat
    Clinical Epidemiology and Biostatistics, Inserm U717, University Paris 7, Paris, France
    Intensive Care Med 36:1993-2003. 2010
    ..No precedent work has focused on the specific application of PS in intensive care and anaesthesiology literature.
  62. ncbi Right ventricular end-diastolic volume index as a predictor of preload status in patients on positive end-expiratory pressure
    M L Cheatham
    Department of Surgical Education, Orlando Regional Medical Center, FL 32806, USA
    Crit Care Med 26:1801-6. 1998
    ....
  63. ncbi Computerized decision support for mechanical ventilation of trauma induced ARDS: results of a randomized clinical trial
    B A McKinley
    Department of Anesthesiology, University of Texas Houston Medical School, Houston, Texas 77030, USA
    J Trauma 50:415-24; discussion 425. 2001
    ..The Memorial Hermann Hospital Shock Trauma intensive care unit (ICU) (Houston, TX; a Level I trauma center and teaching affiliate of The University of Texas Houston ..
  64. ncbi Similarity of changes in body composition in intensive care patients following severe sepsis or major blunt injury
    L D Plank
    University Department of Surgery, Auckland Hospital, New Zealand
    Ann N Y Acad Sci 904:592-602. 2000
    Critically ill patients admitted to the intensive care unit with severe sepsis or major blunt injury undergo massive changes in body composition...
  65. doi Antiplatelet drugs and outcome in mixed admissions to an intensive care unit
    Johannes Winning
    Medical Doctor and Senior Officer, Clinic of Anesthesiology and Intensive Care Medicine, University Hospital Jena, Jena, Germany
    Crit Care Med 38:32-7. 2010
    Platelet activation has been implicated in microvascular thrombosis and organ failure. We tested the hypothesis that antiplatelet drugs favorably affect outcome in patients nonelectively admitted to an intensive care unit.
  66. pmc The PRaCTICaL study of nurse led, intensive care follow-up programmes for improving long term outcomes from critical illness: a pragmatic randomised controlled trial
    B H Cuthbertson
    Department of Critical Care Medicine, Sunnybrook Health Sciences Centre, Toronto
    BMJ 339:b3723. 2009
    To test the hypothesis that nurse led follow-up programmes are effective and cost effective in improving quality of life after discharge from intensive care.
  67. ncbi Consensus meeting on microdialysis in neurointensive care
    Bo Michael Bellander
    Section of Neurosurgery, Department of Clinical Neuroscience, Karolinska Institutet and Hospital, Stockholm, Sweden
    Intensive Care Med 30:2166-9. 2004
    ..Microdialysis is used in many European neurointensive care units to monitor brain chemistry in patients suffering subarachnoid hemorrhage (SAH) or traumatic brain injury (TBI)...
  68. pmc Intensive care diaries reduce new onset post traumatic stress disorder following critical illness: a randomised, controlled trial
    Christina Jones
    ICU, Whiston Hospital, Warrington Road, Prescot L35 5DR, UK
    Crit Care 14:R168. 2010
    ..This study was to evaluate whether a prospectively collected diary of a patient's intensive care unit (ICU) stay when used during convalescence following critical illness will reduce the development of new ..
  69. ncbi Bispectral index-guided sedation with dexmedetomidine in intensive care: a prospective, randomized, double blind, placebo-controlled phase II study
    Andreas E Triltsch
    Department of Anesthesiology and Intensive Care Medicine, Benjamin Franklin Medical Center, Free University of Berlin, Germany
    Crit Care Med 30:1007-14. 2002
    To compare dexmedetomidine vs. placebo with respect to the amount of additional propofol and morphine used for bispectral index-guided sedation and analgesia in mechanically ventilated, intensive care patients after surgery.
  70. ncbi Is continuous infusion ceftriaxone better than once-a-day dosing in intensive care? A randomized controlled pilot study
    Jason A Roberts
    Royal Brisbane and Women s Hospital, Brisbane Australia
    J Antimicrob Chemother 59:285-91. 2007
    ..To compare the clinical and bacteriological outcome of critically ill patients with sepsis treated by ceftriaxone administered as a once-a-day intermittent bolus dose or by 24 h continuous infusion...
  71. doi Clinical relevance of intra-abdominal hypertension in patients with severe acute pancreatitis
    Ahmed Z Al-Bahrani
    Department of Surgery, Hemel Hempstead Hospital, Hemel Hempstead, UK
    Pancreas 36:39-43. 2008
    ..This study aims to investigate the clinical significance of IAH in patients with severe acute pancreatitis (SAP)...
  72. ncbi Antibacterial dosing in intensive care: pharmacokinetics, degree of disease and pharmacodynamics of sepsis
    Jason A Roberts
    Burns, Trauma and Critical Care Research Centre, The University of Queensland, Brisbane, Queensland, Australia
    Clin Pharmacokinet 45:755-73. 2006
    ..Some patients with serum creatinine values within the normal range can have very high drug clearances, thereby producing low serum drug levels and again leading to underdosing...
  73. ncbi Survey of intensive care physicians on the recognition and management of intra-abdominal hypertension and abdominal compartment syndrome
    Edward J Kimball
    University of Utah Health Sciences Center, Salt Lake City, 84132, USA
    Crit Care Med 34:2340-8. 2006
    ..To assess current understanding and clinical management of intra-abdominal hypertension and abdominal compartment syndrome among critical care physicians...
  74. doi Pre-hospital airway management: guidelines from a task force from the Scandinavian Society for Anaesthesiology and Intensive Care Medicine
    P Berlac
    Copenhagen Mobile Intensive Care Unit, Rigshospitalet, Capital Region of Denmark, Copenhagen, Denmark
    Acta Anaesthesiol Scand 52:897-907. 2008
    ..For anaesthesiologists, the Task Force commissioned by the Scandinavian Society of Anaesthesia and Intensive Care Medicine recommends endotracheal intubation (ETI) following rapid sequence induction when securing the pre-..
  75. pmc Interventions to reduce medication errors in adult intensive care: a systematic review
    Elizabeth Manias
    Melbourne School of Health Sciences, University of Melbourne, Parkville, Victoria, Australia
    Br J Clin Pharmacol 74:411-23. 2012
    ..systematically the research literature on the efficacy of interventions in reducing medication errors in intensive care. A search was conducted of PubMed, CINAHL EMBASE, Journals@Ovid, International Pharmaceutical Abstract Series ..
  76. ncbi [Metabolism monitoring with microdialysis in the intensive care]
    Filip Bursa
    Anesteziologicko resuscitacní klinika FN, Ostrava
    Cas Lek Cesk 150:605-9. 2011
    ..Precious information about mitochondrial dysfunction which is the essence of multiorgan dysfunction in intensive care is collected as well...
  77. ncbi A national survey of intensive care follow-up clinics
    J A Griffiths
    Nuffield Department of Anaesthetics, John Radcliffe Hospital, Oxford, UK
    Anaesthesia 61:950-5. 2006
    b>Intensive care follow-up clinics allow extended review of survivors of critical illness. However, the current provision of intensive care follow-up clinics in the UK is unknown...
  78. ncbi Returning home after intensive care: a comparison of symptoms of anxiety and depression in ICU and elective cardiac surgery patients and their relatives
    Ellen Young
    Department of Behavioural Medicine, Hope Hospital, Clinical Sciences Building, Stott Lane, Salford, Manchester M6 8HD, UK
    Intensive Care Med 31:86-91. 2005
    This study gathered data on symptoms of anxiety and depression in patients and relatives after discharge from intensive care and examined whether the intensive care population differ from an elective cardiac surgery group with regards to ..
  79. doi Validity of the Faces Anxiety Scale for the assessment of state anxiety in intensive care patients not receiving mechanical ventilation
    Sharon McKinley
    Critical Care Nursing Professorial Unit, University of Technology Sydney and Northern Sydney Central Coast Health, NSW, Australia
    J Psychosom Res 64:503-7. 2008
    Anxiety is a commonly reported discomfort in critically ill patients in the intensive care unit (ICU) but is rarely assessed routinely in a systematic manner...
  80. doi Predicting death and readmission after intensive care discharge
    A J Campbell
    Department of Anaesthesia, Western Infirmary, Glasgow G11 6NT, UK
    Br J Anaesth 100:656-62. 2008
    Despite initial recovery from critical illness, many patients deteriorate after discharge from the intensive care unit (ICU)...
  81. pmc A 9-Year retrospective review of antibiotic cycling in a surgical intensive care unit
    Shiva Sarraf-Yazdi
    Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA
    J Surg Res 176:e73-8. 2012
    Six years after initiating a monthly antibiotic cycling protocol in the surgical intensive care unit (SICU), we retrospectively reviewed antibiogram-derived sensitivities of predominant gram-negative pathogens before and after antibiotic ..
  82. pmc Recollection of children following intensive care
    S Playfor
    Paediatric Critical Care Unit, The Hospital for Sick Children, 555 University Avenue, Toronto M5G 1X8, Canada
    Arch Dis Child 83:445-8. 2000
    The recollections of critically ill children following discharge from the paediatric intensive care unit (PICU) have not previously been described. We have interviewed such children to establish the nature of their recollections.
  83. doi Managing new oral anticoagulants in the perioperative and intensive care unit setting
    Jerrold H Levy
    Department of Anesthesiology Critical Care, Duke University School of Medicine, Durham, North Carolina 27710, USA
    Anesthesiology 118:1466-74. 2013
    ..Additional clinical studies are needed to determine the best method for reversal of the novel oral anticoagulation agents when bleeding occurs...
  84. pmc Severe imported falciparum malaria among adults requiring intensive care: a retrospective study at the hospital for tropical diseases, London
    Michael E Marks
    The Hospital for Tropical Diseases, Mortimer Market Centre, Capper Street, WC1E 6JB, London, UK
    BMC Infect Dis 13:118. 2013
    ..The relationship between ethnicity, immunity, and risk of malaria is complex. The Malaria Score for Adults (MSA) and Coma Acidosis Malaria (CAM) score have recently been proposed to risk stratify patients with malaria...
  85. pmc Cognitive and physical rehabilitation of intensive care unit survivors: results of the RETURN randomized controlled pilot investigation
    James C Jackson
    Department of Medicine, Center for Health Services Research, Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, TN, USA
    Crit Care Med 40:1088-97. 2012
    Millions of patients who survive medical and surgical general intensive care unit care every year experience newly acquired long-term cognitive impairment and profound physical and functional disabilities...
  86. doi C-reactive protein as a predictor of outcome after discharge from the intensive care: a prospective observational study
    N Al-Subaie
    St George s University of London, Cranmer Terrace, London SW17 0RE, UK
    Br J Anaesth 105:318-25. 2010
    Recent studies have found plasma C-reactive protein (CRP) to be a predictor of outcome after discharge from the intensive care unit (ICU)...
  87. doi The self-fulfilling prophecy in intensive care
    Dominic Wilkinson
    The Ethox Centre, Department of Public Health and Primary Health Care, The University of Oxford, Badenoch Building, Headington OX3 7LF, UK
    Theor Med Bioeth 30:401-10. 2009
    ..This paper outlines the epistemic and normative problems raised by self-fulfilling prophecies (SFPs) in intensive care. Where predictions affect outcome, it can be extremely difficult to ascertain the mortality rate for patients ..
  88. ncbi Nursing activities score
    Dinis Reis Miranda
    University Hospital Groningen, The Netherlands
    Crit Care Med 31:374-82. 2003
    The instruments used for measuring nursing workload in the intensive care unit (e.g., Therapeutic Intervention Scoring System-28) are based on therapeutic interventions related to severity of illness...
  89. ncbi Intensive care unit mobility practices in Australia and New Zealand: a point prevalence study
    Susan C Berney
    Department of Physiotherapy, School of Health Sciences, University of Melbourne, Melbourne, Vic, Australia
    Crit Care Resusc 15:260-5. 2013
    ..describing physiotherapy mobilisation practices for critically ill patients, and to document current practices in intensive care units in Australia and New Zealand, focusing on patients having > 48 hours of mechanical ventilation.
  90. doi A prospective comparison of galactomannan in bronchoalveolar lavage fluid for the diagnosis of pulmonary invasive aspergillosis in medical patients under intensive care: comparison with the diagnostic performance of galactomannan and of (1→ 3)-β-d-glucan
    J Acosta
    Department of Medical Microbiology, Hospital Universitario 12 de Octubre, Madrid, Spain
    Clin Microbiol Infect 17:1053-60. 2011
    ..In patients with IA, GM (90%) and BG (80%) appeared a mean of 4.3 days (range, 1-10 days) before Aspergillus was cultured. GM detection in BAL appears to improve the diagnosis of IA in critical patients...
  91. doi Successful eradication of a monoclonal strain of Klebsiella pneumoniae during a K. pneumoniae carbapenemase-producing K. pneumoniae outbreak in a surgical intensive care unit in Miami, Florida
    L Silvia Munoz-Price
    Division of Infectious Diseases, Department of Medicine, University of Miami, and Jackson Memorial Hospital, Miami, FL, USA
    Infect Control Hosp Epidemiol 31:1074-7. 2010
    ..pneumoniae outbreak in a 20-bed surgical intensive care unit during the period from January 1, 2009 through January 1, 2010...
  92. doi Impact of nosocomial infections on clinical outcome and resource consumption in critically ill patients
    Heinz Burgmann
    Division of Infectious Diseases and Tropical Medicine, Department of Medicine I, Medical University of Vienna, Vienna, Austria
    Intensive Care Med 36:1597-601. 2010
    Nosocomial infections still present a major problem in intensive care units (ICUs), accounting for prolonged ICU and hospital stays and worsened outcomes...
  93. pmc A comparison of three scoring systems for mortality risk among retrieved intensive care patients
    S M Tibby
    Department of Paediatric Intensive Care, Guy s Hospital, London, UK
    Arch Dis Child 87:421-5. 2002
    To assess the impact of two paediatric intensive care unit retrieval teams on the performance of three mortality risk scoring systems: pre-ICU PRISM, PIM, and PRISM II.
  94. pmc Preferential skeletal muscle myosin loss in response to mechanical silencing in a novel rat intensive care unit model: underlying mechanisms
    Julien Ochala
    Department of Neuroscience, Clinical Neurophysiology, Uppsala University, Uppsala, Sweden
    J Physiol 589:2007-26. 2011
    The muscle wasting and impaired muscle function in critically ill intensive care unit (ICU) patients delay recovery from the primary disease, and have debilitating consequences that can persist for years after hospital discharge...
  95. doi Smoking in relation to ST-segment elevation acute myocardial infarction: findings from the Register of Information and Knowledge about Swedish Heart Intensive Care Admissions
    L Bjorck
    Department of Emergency and Cardiovascular Medicine, Sahlgrenska Academy University of Gothenburg, Goteborg, Sweden
    Heart 95:1006-11. 2009
    ..However, changes in risk factors have also been documented, especially lower tobacco-smoking rates. Therefore, the relation between smoking and ST-elevation AMI in a large observational cohort was analysed...
  96. doi Severity of illness and risk of readmission to intensive care: a meta-analysis
    Steven A Frost
    Intensive Care Liverpool Hospital, Australia University of Western Sydney, Australia
    Resuscitation 80:505-10. 2009
    Almost one in every 10 patients who survive intensive care will be readmitted to the intensive care unit (ICU) during the same hospitalisation...
  97. doi Challenges in transition from intervention to end of life care in intensive care: a qualitative study
    Maureen A Coombs
    Cardiac Intensive Care Unit, Southampton University Hospitals Trust, Tremona Road, Southampton, Hampshire SO16 6YD, United Kingdom
    Int J Nurs Stud 49:519-27. 2012
    Providing quality end of life care is a challenging area in intensive care practice...
  98. doi A randomized and blinded single-center trial comparing the effect of intracranial pressure and intracranial pressure wave amplitude-guided intensive care management on early clinical state and 12-month outcome in patients with aneurysmal subarachnoid hemo
    Per Kristian Eide
    Department of Neurosurgery, Oslo University Hospital Rikshospitalet, Oslo, Norway
    Neurosurgery 69:1105-15. 2011
    ....
  99. doi A comparison of SAPS II and SAPS 3 in a Norwegian intensive care unit population
    K Strand
    Department of Anesthesia and Intensive Care, Stavanger University Hospital, Stavanger, Norway
    Acta Anaesthesiol Scand 53:595-600. 2009
    Simplified Acute Physiology Score (SAPS II) is the most widely used general severity scoring system in European intensive care medicine...
  100. doi The impact of pre-admission morbidity level on 3-year mortality after intensive care: a Danish cohort study
    C F Christiansen
    Department of Clinical Epidemiology, Aarhus University Hospital, Denmark
    Acta Anaesthesiol Scand 55:962-70. 2011
    Chronic diseases are common among intensive care unit (ICU) patients and may worsen their prognosis. We examined the prevalence and impact of pre-admission/index morbidity among ICU patients compared with a general population cohort.
  101. pmc The use of a standardized PCT-algorithm reduces costs in intensive care in septic patients - a DRG-based simulation model
    M H Wilke
    Dr Wilke GmbH inspiring health, Munich, Germany
    Eur J Med Res 16:543-8. 2011
    ..of clinical treatment and resource consumption namely the length of stay in hospital and especially in the Intensive Care Unit (ICU)...

Research Grants77

  1. Hybrid Optical/Doppler Imaging of Ischemia in NEC - a multicenter trial
    David A Benaron; Fiscal Year: 2010
    ..device;then combining it with ultrasound will be studied in years 2-5, first on the benchtop, and then in the intensive care unit...
  2. Alpha B crystallin as a novel therapeutic for SIRS and Sepsis
    Jonathan B Rothbard; Fiscal Year: 2011
    ..the host response to a bacterial infection or severe trauma, is responsible for over half of the deaths in intensive care units accounting for more than 200,000 deaths per year...
  3. Mitochondrial dysfunction, oxidative stress, and surgical acute kidney injury
    FREDERIC TREMAINE BILLINGS; Fiscal Year: 2013
    ..Studies will be performed in Vanderbilt University Medical Center operating rooms, intensive care units, and clinics, and in Division of Clinical Pharmacology laboratories...
  4. Emergency Neurophysiological Assessment Bedside Logic Engine
    Don M Tucker; Fiscal Year: 2010
    ..This project would create an advanced computing technology for continuous brain monitoring in emergency and intensive care settings...
  5. Wireless At-Risk Infant Monitoring System
    JASON HOLMSTEDT; Fiscal Year: 2012
    ..g., sudden infant death syndrome). While neonatology and neonatal intensive care units (NICUs) have greatly raised the survival rate of at-risk, very low birth weight, and extremely premature ..
  6. Diagnosis of Subglottic Stenosis and Edema in Neonates Using OCT
    Brian Wong; Fiscal Year: 2013
    ..ability to better treat and even prevent subglottic stenosis has improved with technical advances in neonatal intensive care, but diagnosis remains a source of continued controversy and debate...
  7. Effect of Lactobacillus GG on gut permeability and microbiome in VLBW neonates
    ROSE MARIE VISCARDI; Fiscal Year: 2013
    ..Despite improvements in neonatal intensive care, the birth weight-specific incidence of NEC has not changed over the past 2 decades...
  8. Severe H1N1 Influenza Infection During Pregnancy: Pathophysiologic Mechanisms
    Mark Phillippe; Fiscal Year: 2010
    ..S. Among these 34 pregnant women, 11 (32%) required hospitalization, three were admitted to intensive care and one died. This CDC report also noted that among 45 deaths in the U.S...
  9. Clinical and genomic responses to remote ischemic preconditioning
    Brian W McCrindle; Fiscal Year: 2010
    ..and inflammation and their impact, and include duration of mechanical ventilation, duration of stay in the intensive care unit, and physiologic measures over the first 48 hours after surgery...
  10. Novel Therapeutic Targets in Necrotizing Enterocolitis
    Peter J Giannone; Fiscal Year: 2012
    Necrotizing enterocolitis (NEC), a major cause of morbidity and mortality in neonatal intensive care units, is a disease for which there is currently no medical treatment. Treatment of infants that develop NEC is solely supportive...
  11. Pain and Hypoxia in Premature Neonates
    DANILYN MAG AKAT ANGELES; Fiscal Year: 2012
    PROJECT SUMMARY Premature infants admitted to the neonatal intensive care unit (NICU) require up to several hundred procedures during their hospitalization. Many of these are tissue damaging procedures (TDPs) that cause pain...
  12. A novel role for endogenous fructose in ischemic acute kidney injury
    MIGUEL ANGEL LANASPA GARCIA; Fiscal Year: 2013
    ..injury is a common cause of hospitalization with high mortality affecting 30% of patients admitted to the intensive care unit...
  13. Monitoring of Cardiovascular Function in Infants By Transcutaneous Dye Dilution
    Istvan Seri; Fiscal Year: 2013
    ..will lead to the development of a practical device for monitoring CO in minimally instrumented neonates in intensive care, operative and postsurgical settings, and in patients whose condition does not justify the use of central ..
  14. Mitochondrial function and antifungal photodynamic therapy
    Constantine G Haidaris; Fiscal Year: 2011
    ..S. alone. Patients with cancer, AIDS and diabetes, as well as premature infants and individuals requiring intensive care, are among those at risk...
  15. Lactoferrin for Immunomodulation of Systemic Inflammatory Response Syndrome
    Marian L Kruzel; Fiscal Year: 2011
    ..syndrome (SIRS) is a precursor to sepsis, and has been implicated as the leading cause of death in the intensive care unit, with mortality rates ranging from 30% to 90%...
  16. Antenatal betamethasone for persistent pulmonary hypertension of newborn
    Girija G Konduri; Fiscal Year: 2010
    ..The affected infants are hypoxemic and have an increased risk of morbidity and mortality. Advances in newborn intensive care have dramatically improved the survival of infants with PPHN...
  17. Effect of Prone Position on Ventilator-Induced Lung Injury
    Guido Musch; Fiscal Year: 2013
    ..2 million Intensive Care Unit days and 3.6 million hospital days are devoted to the care of patients with ALI...
  18. Biomarker Profiles for Early Diagnosis of Sepsis in Neonates
    JAMES PRESTON MAPES; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Sepsis is a frequent and serious problem in neonatal intensive care units, particularly in very low birth weight (VLBW) infants...
  19. Impact of Temperature Profile on Outcome After Traumatic Brain Injury
    Lori Kennedy Madden; Fiscal Year: 2013
    ..Secondary injuries occur after the primary trauma. Failure to treat secondary injury leads to lengthened intensive care unit and hospital stays and increased mortality...
  20. Genomic actions of progesterone receptors in human myometrial cells
    Sam Mesiano; Fiscal Year: 2010
    ..the final phase of fetal development is best achieved in the womb environment rather than in the neonatal intensive care unit. To this end, we must prevent and/or suppress preterm labor...
  21. Novel non-invasive device for treatment of elevated intracranial pressures
    Keith G Lurie; Fiscal Year: 2011
    ..intracranial pressure and an increase in cerebral perfusion pressure in patients with head injury in a neuro-intensive care unit;and 2) Design and prototype an enhanced, variable vacuum version of the ITPR with self-contained vacuum ..
  22. Exploiting deep ocean biology for biomedical discovery
    David C Rowley; Fiscal Year: 2011
    ..For example, more than 60% of staph infections in intensive care units are resistant to at least one medicine commonly used to treat these infections...
  23. Phase III Study Comparing Albumin and Hetastarch Therapy in Acute Lung Injury
    Gregory S Martin; Fiscal Year: 2013
    ..Caring for patients with ALI requires prolonged mechanical ventilation and supportive intensive care, resulting in reduced quality of life and contributing substantially to healthcare costs...
  24. Advancing a Lead Candidate Hantavirus Pulmonary Syndrome DNA Vaccine
    JAY WILLIAMS HOOPER; Fiscal Year: 2013
    ..HPS is highly pathogenic in men and women of any age with a case-fatality rate of 30-40% even in modern intensive care units. Progression of the disease from first symptoms to respiratory distress and shock can be rapid...
  25. Regulation of HMGB1 Release in Endotoxemia
    Haichao Wang; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Despite recent advance in antibiotic therapy and intensive care, sepsis remains the most common cause of death in the intensive care unit, claiming >225,000 victims annually in the U.S. alone...
  26. Molecular mechanism of apolipoprotein binding to lipopolysaccharides
    PAUL MICHIEL WEERS; Fiscal Year: 2013
    ..When released in the circulation, LPS cause septic shock, a major cause of death in intensive care units. In the current proposal we aim to provide a molecular basis for the apolipoprotein-LPS interaction...
  27. L-carnitine Treatment for Vasopressor Dependent Septic Shock
    Alan E Jones; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): More humans die in the intensive care unit from sepsis than from any other cause. Death from sepsis is the culmination of widespread hypoperfusion, cellular hypoxia, and multiple organ failure...
  28. Plasma iNOS IVD Prognosticates Sepsis Prior to Organ Damage and Dysfunction
    Robert J Webber; Fiscal Year: 2010
    ..assay development project are [1] to conduct a clinical study on 560 subjects, 360 trauma patients admitted to intensive care units (ICUs) at three regional trauma centers and 200 exempt "unlinked, diagnostic specimens" from normal ..
  29. Motivational Incentives to Reduce Secondhand Smoke in NICU Infants'Homes
    Angela L Stotts; Fiscal Year: 2013
    ..Preterm, low birth weight infants admitted to a Neonatal Intensive Care Unit (NICU) are especially vulnerable to the effects of SHSe, with many exhibiting significant respiratory or ..
  30. Regulation of Neutrophilic Lung Inflammation
    John W Christman; Fiscal Year: 2013
    ..and life threatening condition that requires a mechanical breathing machine and other supportive care in an intensive care unit...
  31. Free Hemoglobin Potentiates Pulmonary Vascular Dysfunction in Acute Lung Injury
    JULIE ANNE BASTARACHE; Fiscal Year: 2013
    ..and the Acute Respiratory Distress Syndrome (ALI/ARDS) remain common causes of morbidity and mortality in the intensive care unit. Novel therapies for prevention and treatment are needed...
  32. Modulating Secondary Damage Following Traumatic Brain Injury in the Child
    Stuart H Friess; Fiscal Year: 2013
    ..Research: One of the principal goals of intensive care management of patients with TBI is the stabilization of derangements in cerebrovascular hemodynamics to avoid ..
  33. Role of phosphatidylethanolamine in regulating virulence in Candida albicans
    SARAH ELIZABETH DAVIS; Fiscal Year: 2013
    ..Candida are also the fourth most common cause of systemic infections (~30% mortality rate) in intensive care units This fellowship proposal explores the hypothesis that the phospholipids phosphatidylethanolamine (PE) ..
  34. Pharmacological Management of Delirium
    Malaz Boustani; Fiscal Year: 2013
    ..7 million Americans aged 65 and older spent at least one day in the intensive care unit (ICU) costing MEDICARE a total of $27.5 billion...
  35. Elucidating the A. baumannii response to calprotectin-mediated zinc starvation
    BRITTANY MORTENSEN; Fiscal Year: 2013
    ..pneumonia and causes a diverse number of infections, particularly in highly susceptible individuals in intensive care unit. The rapid development of antibiotic resistance by A...
  36. TREM-1 in Lung Immune Response
    Ruxana T Sadikot; Fiscal Year: 2013
    ..aeruginosa are a leading cause of death in the intensive care unit. The failure rate for antibiotic treatment for P...
  37. Accelerated Biologic Aging and Risk for Sepsis and Organ Failure Following Trauma
    ELIZABETH GROOMS NESMITH; Fiscal Year: 2012
    ..premature) aging and chronic stress before trauma could explain why some individuals have poor outcomes in the intensive care unit after trauma, such as sepsis and organ failure...
  38. Molecular Basis for Priming of the Neutrophil NADPH Oxidase in Trauma and Sepsis
    ALBERT T HSU; Fiscal Year: 2010
    The leading cause of morbidity in Surgical Intensive Care Units in the U.S. is acute lung injury and respiratory failure due to sepsis and trauma, leading to multi-organ system failure (MOSF) and death...
  39. Validation in Baboon Model of Broadband NIR Monitoring for Neonate Gut Perfusion
    David A Benaron; Fiscal Year: 2012
    ..Impaired intestinal function is a major source of morbidity and mortality in neonatal intensive care. Intestinal dysfunction is manifested by feeding intolerance, poor growth, malabsorbtion, and, in the severest ..
  40. HALF-PINT: Heart and Lung Failure - Pediatric INsulin Titration trial - CCC
    Vinay M Nadkarni; Fiscal Year: 2013
    ..applicant): Heart and lung failure are the most common causes of death in critically ill children in Pediatric Intensive Care Units (PICUs)...
  41. 1st Tier Drugs+Theophylline in Pediatric Severe Asthma
    JERRY JOHN ZIMMERMAN; Fiscal Year: 2010
    ..of continuously nebulized albuterol, as assessed every two hours after admission to the Pediatric Intensive Care Unit...
  42. A Novel Therapy for Septic Shock
    Xiaoling Qiang; Fiscal Year: 2011
    ..Septic shock is the leading cause of death in non-cardiac intensive care units...
  43. Testing the feasibility of patient-controlled sedation in ventilated ICU patients
    Craig R Weinert; Fiscal Year: 2013
    ..provided by applicant): Mechanical ventilation (MV) is the most frequently used life-support modality in intensive care units (ICUs)...
  44. Diagnosis of sub-clinical cryptic group A streptococcal myonecrosis
    Amy Evelyn Bryant; Fiscal Year: 2013
    ..Despite modern antibiotic regimens and intensive care measures, morbidity remains high and mortality ranges from 30 - 60%...
  45. Cooperative Multicenter Maternal Fetal Medicine Units Networks
    John M Thorp; Fiscal Year: 2013
    ..UNC, Wake AHEC/WakeMed, and MAHEC/Mission have state of the art Level III neonatal intensive care units, and Rex has a Level II nursery...
  46. Probiotics and Innate Intestinal Defense
    PATRICIA LANEE WEI DENNING; Fiscal Year: 2013
    Abstract: Necrotizing enterocolitis (NEC) is a leading cause of morbidity and mortality in the neonatal intensive care unit (NICU)...
  47. The MIND USA Study
    E Wesley Ely; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: Millions of critically ill patients every year develop confusion (delirium) while in Intensive Care Units (ICUs), and though a large portion of these patients go undetected and untreated, ICU teams most often ..
  48. Maturation of intestinal innate immunity and NEC
    W Allan Walker; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: Despite the recent advances of neonatal intensive care, necrotizing enterocolitis (NEC) remains a major health complication for the premature infants and an ..
  49. Physiological Disturbances Associated with Neonatal Intraventricular Hemorrhage
    JEFFREY RADIN KAISER; Fiscal Year: 2012
    ..disturbances of carbon dioxide, blood pressure, and autonomic function are common in ELBW infants undergoing intensive care, our central hypothesis is that alterations and extremes of these physiological factors that influence ..
  50. Confirmatory Screening for Congenital Non-Syndromic Genetic Hearing Loss Using Ta
    Edwin W Naylor; Fiscal Year: 2013
    ..Newborns in the neonatal intensive care units are more likely to suffer from hearing loss as a toxic side effect of the antibiotics which are ..
  51. Prompt Diagnosis and Treatment of Subclinical Seizures After Cardiac Arrest
    Alexis A Topjian; Fiscal Year: 2013
    ..with her mentors has implemented a 24 hour per day/7 days per week Neuro-monitoring system in the pediatric intensive care unit which will serve as the foundation for performing her research...
  52. Innate immune suppression following experimental injury
    KRISTIN C GREATHOUSE; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Nosocomial infections (NI) during hospitalization in the intensive care unit (ICU) are a significant proportion of health-related cost, morbidity, and mortality in critically injured adults and ..
  53. A novel treatment, TAT-HSP70, in attenuating lung injury in sepsis induced ARDS
    MARY MELANIE LYONS; Fiscal Year: 2012
    ..Indeed, recent studies have shown that early mobilization of ARDS patients decreases intensive care unit and hospital length of stay...
  54. HALF-PINT: Heart And Lung Failure - Pediatric INsulin Titration trial - DCC
    David Wypij; Fiscal Year: 2013
    ..applicant): Heart and lung failure are the most common causes of death in critically ill children in Pediatric Intensive Care Units (PICUs)...
  55. Mechanisms of diaphragm muscle dysfunction in critical-illness myopathy
    CATHERINE S SASSOON; Fiscal Year: 2012
    ..Acquired muscle weakness in the Intensive Care Unit, referred to "critical-illness myopathy," occurs commonly in patients receiving prolonged mechanical ..
  56. Perioperative Use and Outcomes of Noninvasive Ventilation in Sleep Apnea
    Peter K Lindenauer; Fiscal Year: 2013
    ..adverse events including respiratory failure and cardiovascular complications, increased need for intensive care unit admission, and prolonged hospitalization...
  57. Heat Waves, Medication Use, and Adverse Health Outcomes Among Older Adults
    SOKO SETOGUCHI-IWATA; Fiscal Year: 2013
    ..heat-related side effects of these medications, and (2) quantify health care resource use (hospitalizations, intensive care unit stays, and costs) during heat waves, considering both the direct effects of heat waves and the effects of ..
  58. Development of an instrument to track oxygen from blood to mitochondria in vivo
    Kenneth A Schenkman; Fiscal Year: 2013
    ..Our long-term goal is to develop the cell oximeter for clinical use in ambulances, emergency departments, intensive care units, and operating rooms.
  59. Altering Sedation Paradigms to Improve Brain Injury and Survival in Severe Sepsis
    Pratik Pandharipande; Fiscal Year: 2013
    ..The need for mechanical ventilation (MV) secondary to sepsis is the leading cause of admission to the intensive care unit, often necessitating sedation for patient safety and comfort...
  60. Enhancing cancer outreach for low-income adults with innovative smoking cessation
    Damon J Vidrine; Fiscal Year: 2013
    ..interviewing counseling session and a cell phone-delivered text/graphical messaging component;and an Intensive Care (IC) approach, consisting of all SC and EC components plus a series of 11 cell phone-delivered proactive ..
  61. Identifying novel small molecules for improved antifungal drug treatment
    Martha L Bulyk; Fiscal Year: 2012
    ..Infections caused by pathogenic Candida species are especially prevalent, affecting nearly one in fifty intensive care unit patients and causing nearly 10% of all ICU-acquired bloodstream infections in North America...
  62. A Model-integrated, Guideline-driven Process Management System for Sepsis
    Arthur P Wheeler; Fiscal Year: 2010
    ..Patients with severe disease often require intensive care unit management, endure prolonged hospital stays, and consume substantial healthcare resources...
  63. NICHD Cooperative Multicenter Neonatal Research Network
    Abbot R Laptook; Fiscal Year: 2013
    ..Network since 1991 and patients for Network studies are derived from a new, state of the art 80 bed Neonatal Intensive Care Unit (NICU) of Women and Infants Hospital of Rhode Island (WIH)...
  64. Intrathoracic Pressure Regulation for the Treatment of Septic Shock
    Keith Lurie; Fiscal Year: 2009
    ..in the treatment of patients with sepsis, sepsis remains the second most common cause of death in non-coronary intensive care units and the tenth leading cause of death overall in high-income countries...
  65. DEVELOPMENT EFFECT ON LOOP DIURETIC OTOTOXICITY
    Leonard Rybak; Fiscal Year: 1999
    Loop diuretics are widely used to treat premature infants in neonatal intensive care units. Recent reports have suggested an increased risk of permanent sensorineural hearing loss among infants receiving such treatments...
  66. Comprehensive Clinical Decision Support for the Primary Care of Premature Infants
    Robert W Grundmeier; Fiscal Year: 2010
    ..With recent advances in neonatal care, more premature infants are surviving to discharge from the neonatal intensive care unit (NICU)...
  67. Potential of ICU telemedicine to improve patient safety, reduce morbidity & morta
    JAMES A L MATHERS; Fiscal Year: 2010
    ..Over 4 million patients are admitted to an intensive care unit each year, and ICU related costs exceed $50 billion annually...
  68. MULTICENTER NETWORK OF NEONATAL INTENSIVE CARE UNITS
    T O SHEA; Fiscal Year: 2005
    ..These two nurseries contain over 90% of the level ill neonatal intensive care unit beds in a 19-county region in northwest North Carolina...
  69. Extracorporeal Support for Emergent (Uncontrolled) Donation Following Cardiac Dea
    Shawn J Pelletier; Fiscal Year: 2010
    ..in reestablishing circulation, a determination that is made by physicians within an emergency department or intensive care unit...
  70. Accelerating Adoption of Comparative Effectiveness Research in Premature Infants
    Phillip Brian Smith; Fiscal Year: 2010
    ..use of 6 of the 12 most common medications (antibiotics, antacids, and steroids) administered in the neonatal intensive care unit...
  71. Susceptibility Testing, Treatment Choices, and Outcomes of MDR-GNB Infections
    Lisa Saiman; Fiscal Year: 2009
    ..the 'post-antimicrobial era'has been looming for well over a decade as patients, particularly in intensive care units (ICUs), are increasingly developing infections caused by multidrug-resistant (MDR) pathogens...
  72. Detection of Antibiotic Resistance Genes in Bacterial Agents of Hospital-Acquired
    Andrew Levin; Fiscal Year: 2009
    ..and sepsis are leading causes of morbidity and mortality in critically ill patients, especially in hospital intensive care units...
  73. NEOPAIN MULTICENTER TRIAL: DATA COORDINATING CENTER
    Bruce Barton; Fiscal Year: 2001
    Frequent invasive procedures occur during neonatal intensive care causing pain and stress in preterm neonates during a critical period of increased brain plasticity...
  74. The Effects of Neonatal Intensive Care Deregionalization on Treatment and Infant
    SETH FREEDMAN; Fiscal Year: 2009
    DESCRIPTION (provided by the applicant): Neonatal Intensive Care Units (NICUs) have greatly improved health outcomes for sick, preterm, and underweight infants...
  75. Childhood After Preterm Birth: The Preschool Years
    LISA MCELANEY; Fiscal Year: 2007
    ..e., after a pregnancy of less than 37 weeks. As more of these infants leave the neonatal intensive care unit for home, we are just beginning to recognize the special needs of these young children as infants and ..
  76. Dose of Early Therapeutic Mobility: Does Type or Frequency of Activity Matter?
    Chris Winkelman; Fiscal Year: 2010
    ..is not known and there are limited reports about the application and effects of ETM in mechanically ventilated intensive care unit (ICU) patients...
  77. Prospective Multicenter Study of Bronchiolitis Admissions: Etiology & Disposition
    Carlos A Camargo; Fiscal Year: 2010
    ..who would require continuous positive airway pressure or intubation and those who would not require intensive care. 3) To develop hospital discharge guidelines that encourage earlier, but safe discharges and foster family-..