critical care

Summary

Summary: Health care provided to a critically ill patient during a medical emergency or crisis.

Top Publications

  1. ncbi Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008
    R Phillip Dellinger
    Cooper University Hospital, Camden, NJ, USA
    Crit Care Med 36:296-327. 2008
  2. ncbi Early physical and occupational therapy in mechanically ventilated, critically ill patients: a randomised controlled trial
    William D Schweickert
    Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, University of Pennsylvania, Philadelphia, PA, USA
    Lancet 373:1874-82. 2009
  3. ncbi Management of hyperglycemia in hospitalized patients in non-critical care setting: an endocrine society clinical practice guideline
    Guillermo E Umpierrez
    Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Clin Endocrinol Metab 97:16-38. 2012
  4. pmc Early goal-directed therapy after major surgery reduces complications and duration of hospital stay. A randomised, controlled trial [ISRCTN38797445]
    Rupert Pearse
    Adult Intensive Care Unit, St George s Hospital, Blackshaw Road, London SW17 0QT, UK
    Crit Care 9:R687-93. 2005
  5. ncbi Critical care in resource-poor settings: lessons learned and future directions
    Elisabeth D Riviello
    Brigham and Women s Hospital, Department of Internal Medicine, Boston, MA, USA
    Crit Care Med 39:860-7. 2011
  6. ncbi Guidelines for evaluation of new fever in critically ill adult patients: 2008 update from the American College of Critical Care Medicine and the Infectious Diseases Society of America
    NAOMI P O'GRADY
    National Institutes of Health, Bethesda, MD, USA
    Crit Care Med 36:1330-49. 2008
  7. ncbi American College of Chest Physicians/La Société de Réanimation de Langue Française statement on competence in critical care ultrasonography
    Paul H Mayo
    Department of Medicine, Long Island Jewish Medical Center, 410 Lakeville Road, New Hyde Park, NY 11140, USA
    Chest 135:1050-60. 2009
  8. ncbi Low serum 25-hydroxyvitamin D at critical care initiation is associated with increased mortality
    Andrea B Braun
    Renal Division, Brigham and Women s Hospital, Boston, MA, USA
    Crit Care Med 40:63-72. 2012
  9. ncbi Performance-enhancing sports supplements: role in critical care
    Lindsay Rae B Weitzel
    Department of Anesthesiology, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA
    Crit Care Med 37:S400-9. 2009
  10. ncbi Simulation-based crisis resource management training for pediatric critical care medicine: a review for instructors
    Adam Cheng
    Division of Emergency Medicine, Alberta Children s Hospital, Calgary, Canada
    Pediatr Crit Care Med 13:197-203. 2012

Detail Information

Publications390 found, 100 shown here

  1. ncbi Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008
    R Phillip Dellinger
    Cooper University Hospital, Camden, NJ, USA
    Crit Care Med 36:296-327. 2008
    ..To provide an update to the original Surviving Sepsis Campaign clinical management guidelines, "Surviving Sepsis Campaign Guidelines for Management of Severe Sepsis and Septic Shock," published in 2004...
  2. ncbi Early physical and occupational therapy in mechanically ventilated, critically ill patients: a randomised controlled trial
    William D Schweickert
    Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, University of Pennsylvania, Philadelphia, PA, USA
    Lancet 373:1874-82. 2009
    ..We assessed the efficacy of combining daily interruption of sedation with physical and occupational therapy on functional outcomes in patients receiving mechanical ventilation in intensive care...
  3. ncbi Management of hyperglycemia in hospitalized patients in non-critical care setting: an endocrine society clinical practice guideline
    Guillermo E Umpierrez
    Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Clin Endocrinol Metab 97:16-38. 2012
    The aim was to formulate practice guidelines on the management of hyperglycemia in hospitalized patients in the non-critical care setting.
  4. pmc Early goal-directed therapy after major surgery reduces complications and duration of hospital stay. A randomised, controlled trial [ISRCTN38797445]
    Rupert Pearse
    Adult Intensive Care Unit, St George s Hospital, Blackshaw Road, London SW17 0QT, UK
    Crit Care 9:R687-93. 2005
    ..The aim of this study was to evaluate the effect of post-operative GDT on the incidence of complications and duration of hospital stay in patients undergoing general surgery...
  5. ncbi Critical care in resource-poor settings: lessons learned and future directions
    Elisabeth D Riviello
    Brigham and Women s Hospital, Department of Internal Medicine, Boston, MA, USA
    Crit Care Med 39:860-7. 2011
    b>Critical care faces the same challenges as other aspects of healthcare in the developing world. However, critical care faces an additional challenge in that it has often been deemed too costly or complicated for resource-poor settings...
  6. ncbi Guidelines for evaluation of new fever in critically ill adult patients: 2008 update from the American College of Critical Care Medicine and the Infectious Diseases Society of America
    NAOMI P O'GRADY
    National Institutes of Health, Bethesda, MD, USA
    Crit Care Med 36:1330-49. 2008
    ..To update the practice parameters for the evaluation of adult patients who develop a new fever in the intensive care unit, for the purpose of guiding clinical practice...
  7. ncbi American College of Chest Physicians/La Société de Réanimation de Langue Française statement on competence in critical care ultrasonography
    Paul H Mayo
    Department of Medicine, Long Island Jewish Medical Center, 410 Lakeville Road, New Hyde Park, NY 11140, USA
    Chest 135:1050-60. 2009
    To define competence in critical care ultrasonography (CCUS).
  8. ncbi Low serum 25-hydroxyvitamin D at critical care initiation is associated with increased mortality
    Andrea B Braun
    Renal Division, Brigham and Women s Hospital, Boston, MA, USA
    Crit Care Med 40:63-72. 2012
    We hypothesized that deficiency in 25-hydroxyvitamin D at critical care initiation would be associated with all-cause mortalities.
  9. ncbi Performance-enhancing sports supplements: role in critical care
    Lindsay Rae B Weitzel
    Department of Anesthesiology, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA
    Crit Care Med 37:S400-9. 2009
    ..It is very possible that, under the supervision of a physician, many of these agents may prove beneficial in the prevention and treatment of post-intensive care unit weakness...
  10. ncbi Simulation-based crisis resource management training for pediatric critical care medicine: a review for instructors
    Adam Cheng
    Division of Emergency Medicine, Alberta Children s Hospital, Calgary, Canada
    Pediatr Crit Care Med 13:197-203. 2012
    ..To review the essential elements of crisis resource management and provide a resource for instructors by describing how to use simulation-based training to teach crisis resource management principles in pediatric acute care contexts...
  11. ncbi Arterial waveform analysis in anesthesia and critical care
    Leon J Montenij
    Division of Anesthesiology, Intensive Care and Emergency Medicine, University Medical Center Utrecht, Utrecht, The Netherlands
    Curr Opin Anaesthesiol 24:651-6. 2011
    ..The validity of commercially based hemodynamic monitoring systems is discussed, together with their clinical applications and limitations...
  12. ncbi Nurse-doctor interactions during critical care ward rounds
    E Manias
    School of Postgraduate Nursing, The University of Melbourne, Carlton, Victoria, Australia
    J Clin Nurs 10:442-50. 2001
    This paper describes the participation of critical care nurses in ward rounds, and explores the power relations associated with the ways in which nurses interact with doctors during this oral forum of communication...
  13. ncbi Discrepant attitudes about teamwork among critical care nurses and physicians
    Eric J Thomas
    University of Texas Houston Medical School, Department of Medicine, Division of General Internal Medicine, USA
    Crit Care Med 31:956-9. 2003
    To measure and compare critical care physicians' and nurses' attitudes about teamwork.
  14. ncbi Critical care management of patients with hemophagocytic lymphohistiocytosis
    Sophie Buyse
    Medical Intensive Care Unit, Clinical Immunology, Pathology and Dermatalogy departments, Saint Louis Teaching Hospital, University Paris 7 Paris Diderot, UFR de Medecine, AP HP, Hopital Saint Louis, 1 avenue Claude Vellefaux, 75010 Paris, France
    Intensive Care Med 36:1695-702. 2010
    ..We sought to describe ICU management and outcomes in HLH patients meeting HLH-2004 criteria and to identify determinants of mortality...
  15. ncbi Critical care management of patients following aneurysmal subarachnoid hemorrhage: recommendations from the Neurocritical Care Society's Multidisciplinary Consensus Conference
    Michael N Diringer
    Neurology Neurosurgery Intensive Care Unit, Washington University, St Louis, MO, USA
    Neurocrit Care 15:211-40. 2011
    ..prevention, natural history, and prevention of rebleeding, but provide limited discussion of the complex critical care issues involved in the care of SAH patients...
  16. ncbi Dexmedetomidine: applications in pediatric critical care and pediatric anesthesiology
    Joseph D Tobias
    Department of Anesthesiology, University of Missouri, Columbia, MO, USA
    Pediatr Crit Care Med 8:115-31. 2007
    ..To provide a general descriptive account of the end-organ effects of dexmedetomidine and to provide an evidence-based review of the literature regarding its use in infants and children...
  17. pmc Delirium epidemiology in critical care (DECCA): an international study
    Jorge I Salluh
    Intensive Care Unit and Postgraduate Program, Instituto Nacional de Cancer, 10 Andar Praça Cruz Vermelha, 23 Rio de Janeiro RJ CEP 20230 130, Brazil
    Crit Care 14:R210. 2010
    ..Delirium is a frequent source of morbidity in intensive care units (ICUs). Most data on its epidemiology is from single-center studies. Our aim was to conduct a multicenter study to evaluate the epidemiology of delirium in the ICU...
  18. ncbi Timing of renal replacement therapy and clinical outcomes in critically ill patients with severe acute kidney injury
    Sean M Bagshaw
    Department of Intensive Care and Department of Medicine, Austin and Repatriation Medical Centre, Melbourne, Australia
    J Crit Care 24:129-40. 2009
    ..The aim of this study is to evaluate the relationship between timing of renal replacement therapy (RRT) in severe acute kidney injury and clinical outcomes...
  19. ncbi Clinical practice guideline: red blood cell transfusion in adult trauma and critical care
    Lena M Napolitano
    Crit Care Med 37:3124-57. 2009
    To develop a clinical practice guideline for red blood cell transfusion in adult trauma and critical care.
  20. pmc Availability of critical care resources to treat patients with severe sepsis or septic shock in Africa: a self-reported, continent-wide survey of anaesthesia providers
    Inipavudu Baelani
    Department of Anaesthesia and Critical Care Medicine, DOCS Hospital, Goma, Democratic Republic of Congo, Africa
    Crit Care 15:R10. 2011
    ..South Africa, Mauritius and the Northern African countries)...
  21. pmc Biomarker discovery and development in pediatric critical care medicine
    Jennifer M Kaplan
    Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center and Cincinnati Children s Research Foundation, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    Pediatr Crit Care Med 12:165-73. 2011
    ..To frame the general process of biomarker discovery and development; and to describe a proposal for the development of a multibiomarker-based risk model for pediatric septic shock...
  22. ncbi Critical care medicine in the United States 2000-2005: an analysis of bed numbers, occupancy rates, payer mix, and costs
    Neil A Halpern
    Critical Care Medicine Service, Department of Anesthesiology and Critical Care Medicine, Memorial Sloan Kettering Cancer Center, New York, USA
    Crit Care Med 38:65-71. 2010
    To analyze the evolving role, patterns of use, and costs of critical care medicine in the United States from 2000 to 2005.
  23. ncbi Effect of 24-hour mandatory versus on-demand critical care specialist presence on quality of care and family and provider satisfaction in the intensive care unit of a teaching hospital
    Ognjen Gajic
    Mayo Clinic College of Medicine, Rochester, MN, USA
    Crit Care Med 36:36-44. 2008
    The benefit of continuous on-site presence by a staff academic critical care specialist in the intensive care unit of a teaching hospital is not known...
  24. ncbi Resuscitation and critical care of poor-grade subarachnoid hemorrhage
    Ricardo J Komotar
    Department of Neurological Surgery, Columbia University, New York, New York 10032, USA
    Neurosurgery 64:397-410; discussion 410-1. 2009
    ....
  25. ncbi Impact of energy deficit calculated by a predictive method on outcome in medical patients requiring prolonged acute mechanical ventilation
    Christophe Faisy
    Assistance Publique Hopitaux de Paris, Hopital Europeen Georges Pompidou, Service de Reanimation Medicale, 20 rue Leblanc, 75908, Paris, France
    Br J Nutr 101:1079-87. 2009
    ....
  26. ncbi Bradycardia during critical care intubation: mechanisms, significance and atropine
    Peter Jones
    Critical Care Group Portex Unit, Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, UK
    Arch Dis Child 97:139-44. 2012
    ..However, clinical studies of critical care intubation show that atropine does not prevent all episodes of bradycardia and specifically cannot affect ..
  27. pmc Determinants of blood pH in health and disease
    J A Kellum
    University of Pittsburgh Medical Center, Division of Critical Care, Pittsburgh, Pennsylvania 15213 2582, USA
    Crit Care 4:6-14. 2000
    An advanced understanding of acid-base physiology is as central to the practice of critical care medicine, as are an understanding of cardiac and pulmonary physiology...
  28. ncbi Critical care guidelines on the endovascular management of cerebral vasospasm
    Matthew M Kimball
    Department of Neurosurgery, University of Florida, 1600 South West Archer Rd, P O Box 100265, Gainesville, FL 32610, USA
    Neurocrit Care 15:336-41. 2011
    ..Limited data are available evaluating nicardipine or verapamil, with positive benefits reported with nicardipine and inconsistent benefits with verapamil...
  29. ncbi Current perceptions and practices surrounding the recognition and treatment of delirium in the intensive care unit: a survey of 250 critical care pharmacists from eight states
    John W Devlin
    School of Pharmacy, Northeastern University, Boston, MA, USA
    Ann Pharmacother 45:1217-29. 2011
    ..Pharmacists are key members of the intensive care unit (ICU) team; however, few data exist regarding their clinical role, perceptions, and current practices in recognizing and managing delirium...
  30. ncbi Basic critical care echocardiography: validation of a curriculum dedicated to noncardiologist residents
    Philippe Vignon
    Medical Surgical Intensive Care Unit, Dupuytren Teaching Hospital, Limoges, France
    Crit Care Med 39:636-42. 2011
    To assess the efficacy of a limited, tailored training program for noncardiologist residents without experience in ultrasound to reach competence in basic critical care echocardiography.
  31. ncbi Epidemiology, management, and risk factors for death of invasive Candida infections in critical care: a multicenter, prospective, observational study in France (2005-2006)
    Olivier Leroy
    Service de Réanimation Médicale et des Maladies Infectieuses, Centre Hospitalier Gustave Dron, Tourcoing, France
    Crit Care Med 37:1612-8. 2009
    ..To describe the evolving epidemiology, management, and risk factors for death of invasive Candida infections in intensive care units (ICUs)...
  32. pmc Critical care management of severe traumatic brain injury in adults
    Samir H Haddad
    Intensive Care Department, King Abdulaziz Medical City, Riyadh, Kingdom of Saudi Arabia
    Scand J Trauma Resusc Emerg Med 20:12. 2012
    ..The critical care management of severe TBI is largely derived from the "Guidelines for the Management of Severe Traumatic Brain ..
  33. ncbi 'Glycaemic variability': a new therapeutic challenge in diabetes and the critical care setting
    A Ceriello
    Insititut d Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain
    Diabet Med 27:862-7. 2010
    ..Avoiding glucose fluctuations in diabetic patients and in critically ill patients seems to be an emerging therapeutic challenge...
  34. ncbi A physiological Intensive Control Insulin-Nutrition-Glucose (ICING) model validated in critically ill patients
    Jessica Lin
    Department of Medicine, University of Otago Christchurch, New Zealand
    Comput Methods Programs Biomed 102:192-205. 2011
    ..Finally, the detailed examination and discussion of issues surrounding model-based TGC and existing glucose-insulin models render this article a mini-review of the state of model-based TGC in critical care.
  35. ncbi Tight glycemic control in critical care--the leading role of insulin sensitivity and patient variability: a review and model-based analysis
    J Geoffrey Chase
    University of Canterbury, Dept of Mechanical Engineering, Centre for Bio Engineering, Private Bag 4800, Christchurch, New Zealand
    Comput Methods Programs Biomed 102:156-71. 2011
    Tight glycemic control (TGC) has emerged as a major research focus in critical care due to its potential to simultaneously reduce both mortality and costs...
  36. ncbi Critical care aspects of malaria
    Pralay K Sarkar
    Division of Pulmonary, Critical Care, and Sleep Medicine, North Shore University Hospital, North Shore Long Island Jewish Health System, New York 11010, USA
    J Intensive Care Med 25:93-103. 2010
    ..About 10% of patients with severe malaria die, usually as a result of multiorgan dysfunction. Critical care physicians should be aware of the complications and management of severe malaria...
  37. ncbi Critical care in low-income countries
    Tim Baker
    Department of Physiology and Pharmacology, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden
    Trop Med Int Health 14:143-8. 2009
    b>Critical care in low-income countries remains rudimentary...
  38. ncbi Impact of transport to critical care medical centers on outcomes after out-of-hospital cardiac arrest
    Kentaro Kajino
    Emergency and Critical Care Medical Center, Osaka Police Hospital, Kitayama cho, 10 31 Tennouji ku, 543 0035 Osaka, Japan
    Resuscitation 81:549-54. 2010
    Post-resuscitation care has emerged as an important predictor of survival from out-of-hospital cardiac arrest (OHCA). In Japan, selected hospitals are certified as Critical Care Medical Centers (CCMCs) based on their ability and expertise.
  39. ncbi Mechanisms of neurologic failure in critical illness
    Aliaksei Pustavoitau
    Department of Anesthesiology Critical Care Medicine, Johns Hopkins University, Baltimore, MD 21287, USA
    Crit Care Clin 24:1-24, vii. 2008
    ..This article provides an overview of research evaluating the relationship between critical illness and neurologic function, with a special emphasis on underlying mechanisms...
  40. ncbi Efficacy and safety of a paired sedation and ventilator weaning protocol for mechanically ventilated patients in intensive care (Awakening and Breathing Controlled trial): a randomised controlled trial
    Timothy D Girard
    Department of Medicine, Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 8300, USA
    Lancet 371:126-34. 2008
    ..Our aim was to assess a protocol that paired spontaneous awakening trials (SATs)-ie, daily interruption of sedatives-with spontaneous breathing trials (SBTs)...
  41. ncbi Impact of antimicrobial stewardship in critical care: a systematic review
    Reham Kaki
    Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    J Antimicrob Chemother 66:1223-30. 2011
    To evaluate the current state of evidence for antimicrobial stewardship interventions in the critical care unit.
  42. ncbi The design and interpretation of pilot trials in clinical research in critical care
    Donald M Arnold
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Crit Care Med 37:S69-74. 2009
    ..The objective of this review is to highlight the importance of randomized pilot trials and to describe key features of their design and interpretation using examples from critical care.
  43. ncbi Critical care nurses' perceptions of and responses to moral distress
    Karen M Gutierrez
    Dimens Crit Care Nurs 24:229-41. 2005
    ..Thus, it is known that moral distress has significant consequences for nurses, but does moral distress affect nurses' provision of care, and if so, how?..
  44. ncbi A systematic review of the Charlson comorbidity index using Canadian administrative databases: a perspective on risk adjustment in critical care research
    Dale M Needham
    Department of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
    J Crit Care 20:12-9. 2005
    The Charlson index is commonly used for risk adjustment in critical care health services research. However, the literature supporting this methodology has not been thoroughly explored...
  45. ncbi Effect of cerebral perfusion pressure augmentation on regional oxygenation and metabolism after head injury
    Andrew J Johnston
    University Department of Anaesthetics, Addenbrooke s Hospital, Cambridge, UK
    Crit Care Med 33:189-95; discussion 255-7. 2005
    ....
  46. ncbi Heart rate variability in critical illness and critical care
    Timothy G Buchman
    Washington University School of Medicine, St Louis, Missouri 63110 1093, USA
    Curr Opin Crit Care 8:311-5. 2002
    ..declines with age, (2) acute changes in HRV are associated with several disease processes that require critical care, (3) measures of HRV can be used to describe the status of critically ill patients, and (4) measures of HRV ..
  47. pmc Acute Kidney Injury Network: report of an initiative to improve outcomes in acute kidney injury
    Ravindra L Mehta
    Department of Medicine, University of California San Diego Medical Center 8342, 200 W, Arbor Drive, San Diego, CA 92103, USA
    Crit Care 11:R31. 2007
    ..We describe an initiative to develop uniform standards for defining and classifying AKI and to establish a forum for multidisciplinary interaction to improve care for patients with or at risk for AKI...
  48. ncbi Reduction in mortality associated with statin therapy in patients with severe sepsis
    Paul P Dobesh
    College of Pharmacy, University of Nebraska Medical Center, Omaha, Nebraska 68198 6045, USA
    Pharmacotherapy 29:621-30. 2009
    ..To evaluate the effect of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) on mortality in patients with severe sepsis...
  49. ncbi Cardiovascular management of septic shock
    R Phillip Dellinger
    Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Section of Critical Care Medicine, Cooper Health System, Camden 08103, USA
    Crit Care Med 31:946-55. 2003
  50. ncbi Caloric intake in medical ICU patients: consistency of care with guidelines and relationship to clinical outcomes
    Jerry A Krishnan
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Chest 124:297-305. 2003
    ..To assess the consistency of caloric intake with American College of Chest Physicians (ACCP) recommendations for critically ill patients and to evaluate the relationship of caloric intake with clinical outcomes...
  51. ncbi Practice and perception--a nationwide survey of therapy habits in sepsis
    Frank M Brunkhorst
    Anesthesiology and Intensive Care Medicine, Friedrich Schiller University Jena, Germany
    Crit Care Med 36:2719-25. 2008
    ..To simultaneously determine perceived vs. practiced adherence to recommended interventions for the treatment of severe sepsis or septic shock...
  52. ncbi Advances in critical care for the nephrologist: acute lung injury/ARDS
    Kathleen D Liu
    Division of Nephrology and Critical Care Medicine, Box 0532, University of California, San Francisco, San Francisco, CA 94143 0532, USA
    Clin J Am Soc Nephrol 3:578-86. 2008
    ..Pharmacologic strategies and other ventilator management strategies have not been successful to date; however, several randomized, placebo controlled treatment trials are ongoing...
  53. ncbi Inflammation, coagulopathy, and the pathogenesis of multiple organ dysfunction syndrome
    J C Marshall
    Department of Surgery, University Health Network, University of Toronto, Ontario, Canada
    Crit Care Med 29:S99-106. 2001
    ....
  54. ncbi Treatment of intracerebral haemorrhage
    Stephan A Mayer
    Neurological Intensive Care Unit, Division of Stroke and Critical Care, Department of Neurology Columbia University, New York, NY 10032, USA
    Lancet Neurol 4:662-72. 2005
    ....
  55. pmc Bench-to-bedside review: avoiding pitfalls in critical care meta-analysis--funnel plots, risk estimates, types of heterogeneity, baseline risk and the ecologic fallacy
    Michael C Reade
    CRISMA Laboratory, Department of Critical Care Medicine, University of Pittsburgh, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    Crit Care 12:220. 2008
    ..Meta-analysis in critical care medicine is made more complicated, however, by the heterogeneous nature of critically ill patients and the ..
  56. ncbi Hypertonic saline in critical care: a review of the literature and guidelines for use in hypotensive states and raised intracranial pressure
    G F Strandvik
    Anaesthesia and Intensive Care Medicine, South Eastern School of Anaesthesia, London, UK
    Anaesthesia 64:990-1003. 2009
    ..Its osmotic and volume-expanding properties make it theoretically useful for a number of indications in critical care. This literature review evaluates the use of hypertonic saline in critical care...
  57. ncbi A trigger tool to identify adverse events in the intensive care unit
    Roger K Resar
    Luther Midelfort, Mayo Health System, Eau Claire, Wisconsin, USA
    Jt Comm J Qual Patient Saf 32:585-90. 2006
    ..The Trigger Tool technique was used to identify the rate of occurrence of adverse events in the intensive care unit (ICU), and a subset of ICUs described those events in detail...
  58. pmc Clinical review: medication errors in critical care
    Eric Moyen
    Department of Critical Care Medicine, University of Calgary, Foothills Medical Centre, EG23A, 1403 29 Street NW, Calgary, AB, Canada
    Crit Care 12:208. 2008
    Medication errors in critical care are frequent, serious, and predictable...
  59. ncbi A blueprint for obstetric critical care
    Gerda G Zeeman
    Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, USA
    Am J Obstet Gynecol 188:532-6. 2003
    The purpose of this study was to describe our 2-year experience with 483 critically ill peripartum women and to propose a blueprint for obstetric critical care.
  60. ncbi Acute kidney injury
    John A Kellum
    Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Crit Care Med 36:S141-5. 2008
    ..The RIFLE criteria provide a uniform definition of acute kidney injury and have now been validated in numerous studies...
  61. ncbi Beneficial effects of humidified high flow nasal oxygen in critical care patients: a prospective pilot study
    Benjamin Sztrymf
    Hopital Louis Mourier, Service de Réanimation medico chirurgicale, Colombes, France
    Intensive Care Med 37:1780-6. 2011
    ..To evaluate the efficiency, safety and outcome of high flow nasal cannula oxygen (HFNC) in ICU patients with acute respiratory failure...
  62. ncbi Clinical and economic outcomes of involving pharmacists in the direct care of critically ill patients with infections
    Robert MacLaren
    Department of Clinical Pharmacy, School of Pharmacy, University of Colorado Denver, Aurora, CO, USA
    Crit Care Med 36:3184-9. 2008
    ....
  63. ncbi Critical care of the burn patient: the first 48 hours
    Barbara A Latenser
    Carver College of Medicine, University of Iowa Hospitals and Clinics, Department of Surgery, Iowa City, Iowa, USA
    Crit Care Med 37:2819-26. 2009
    ..The goal of this concise review is to provide an overview of some of the most important resuscitation and monitoring issues and approaches that are unique to burn patients compared with the general intensive care unit population...
  64. ncbi Nutrition therapy in the critical care setting: what is "best achievable" practice? An international multicenter observational study
    Naomi E Cahill
    Department of Community Health and Epidemiology, Queen s University, and Clinical Evaluation Research Unit, Kingston General Hospital, Kingston, ON, Canada
    Crit Care Med 38:395-401. 2010
    To describe current nutrition practices in intensive care units and determine "best achievable" practice relative to evidence-based Critical Care Nutrition Clinical Practice Guidelines.
  65. pmc Persistent organ dysfunction plus death: a novel, composite outcome measure for critical care trials
    Daren K Heyland
    Department of Medicine, Queen s University, 76 Stuart Street, Kingston, ON K7L 2V7, Canada
    Crit Care 15:R98. 2011
    Due to resource limitations, few critical care interventions have been rigorously evaluated with adequately powered randomized clinical trials (RCTs)...
  66. ncbi Diagnostic and prognostic biomarkers of sepsis in critical care
    Savitri Kibe
    Department of Infection and Tropical Medicine, Castle Hill Hospital, Hull and East Yorkshire Hospitals NHS Trust, Cottingham, East Yorkshire, UK
    J Antimicrob Chemother 66:ii33-40. 2011
    ..predominantly drives broad-spectrum antimicrobial use and the associated evolution of antibiotic resistance in critical care environments...
  67. ncbi Worldwide demand for critical care
    Neill K J Adhikari
    Department of Critical Care Medicine, Sunnybrook Health Sciences Centre and Interdepartmental Division of Critical Care, University of Toronto, Toronto, Ontario, Canada
    Curr Opin Crit Care 17:620-5. 2011
    ..Interest in the global burden of critical illness is growing, but comprehensive data to describe this burden and the resources available to provide care for critically ill patients are lacking...
  68. ncbi What is new in cytokine research related to trauma/critical care
    Randeep S Jawa
    Department of Surgery, SUNY Buffalo, Buffalo, NY 14203, USA
    J Intensive Care Med 21:63-85. 2006
    ..They have the potential to modify cellular responses to these insults. Recent years have seen a plethora of research in cytokine biology in trauma and critical care.
  69. ncbi A physiologically-based early warning score for ward patients: the association between score and outcome
    D R Goldhill
    Anaesthetic Department, The Royal National Orthopaedic Hospital, Brockley Hill, Stanmore, Middlesex HA7 4LP, UK
    Anaesthesia 60:547-53. 2005
    ..Patients were either referred directly from the wards (n = 245, 23.4%) or were routine critical care follow-ups. Decisions were made to admit 135 patients (12...
  70. ncbi National estimates of central line-associated bloodstream infections in critical care patients
    Matthew E Wise
    Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia
    Infect Control Hosp Epidemiol 34:547-54. 2013
    ..Our objective was to describe changes in the annual number of CLABSIs in critical care patients in the United States.
  71. pmc Atropine for critical care intubation in a cohort of 264 children and reduced mortality unrelated to effects on bradycardia
    Peter Jones
    Critical Care Group Portex Unit, Institute of Child Health, University College London, London, Great Britain
    PLoS ONE 8:e57478. 2013
    Atropine has is currently recommended to facilitate haemodynamic stability during critical care intubation. Our objective was to determine whether atropine use at induction influences ICU mortality.
  72. ncbi Prehospital anaesthesia by a physician and paramedic critical care team in Southwest England
    Johannes von Vopelius-Feldt
    aAcademic Department of Emergency Care, Emergency Department, University Hospitals Bristol NHS Foundation Trust bDepartment of Health and Clinical Research, Faculty of Health and Life Sciences, University of the West of England, Bristol, UK
    Eur J Emerg Med 20:382-6. 2013
    ..It is a core skill of the prehospital critical care service established by the Great Western Ambulance Service NHS Trust (GWAS) in 2008...
  73. ncbi Job satisfaction in mainland China: comparing critical care nurses and general ward nurses
    Aihua Zhang
    School of Nursing, Second Military Medical University, Shanghai, China
    J Adv Nurs 69:1725-36. 2013
    To explore the level of nurses' job satisfaction and compare the differences between critical care nurses and general ward nurses in Mainland China.
  74. pmc Utilization of critical care services among patients undergoing total hip and knee arthroplasty: epidemiology and risk factors
    Stavros G Memtsoudis
    Department of Anesthesiology, Hospital for Special Surgery, Weill Medical College of Cornell University, New York, New York 10021, USA
    Anesthesiology 117:107-16. 2012
    A paucity of data exist on the use of critical care services (CCS) among hip and knee arthroplasty patients...
  75. pmc From system to organ to cell: oxygenation and perfusion measurement in anesthesia and critical care
    Patrick Schober
    Department of Anaesthesiology, VU University Medical Center, De Boelelaan 1117, 1007 MB, Amsterdam, The Netherlands
    J Clin Monit Comput 26:255-65. 2012
    ..This article reviews the basic physiology of oxygen uptake and delivery to tissues as well as the options to monitor determinants of oxygenation at different stages from the alveolus to the cell...
  76. ncbi Case-controlled study of critical care or surgical ward care after elective open colorectal surgery
    M Swart
    Department of Anaesthesia and Critical Care Medicine, Torbay Hospital, Torquay TQ2 7AA, UK
    Br J Surg 99:295-9. 2012
    Evidence for the benefit of critical care after surgery is limited. This study assessed the value of immediate admission to the critical care unit (CCU) after open colorectal surgery.
  77. ncbi Unexplained hypotension: the spectrum of dynamic left ventricular outflow tract obstruction in critical care settings
    Anand Chockalingam
    Department of Internal Medicine, Division of Cardiovascular Medicine, University of Missouri School of Medicine, Columbia, MO, USA
    Crit Care Med 37:729-34. 2009
    To illustrate the clinical and hemodynamic abnormalities caused by dynamic left ventricular outflow tract obstruction (LVOTO) in critical care setting.
  78. ncbi The relationship between organizational culture and family satisfaction in critical care
    Peter M Dodek
    Center for Health Evaluation and Outcome Sciences and Division of Critical Care Medicine, Providence Health Care and University of British Columbia, Vancouver, BC, Canada
    Crit Care Med 40:1506-12. 2012
    Family satisfaction with critical care is influenced by a variety of factors. We investigated the relationship between measures of organizational and safety culture, and family satisfaction in critical care...
  79. ncbi Critical care and the global burden of critical illness in adults
    Neill K J Adhikari
    Interdepartmental Division of Critical Care, University of Toronto and Department of Critical Care Medicine, Sunnybrook Health Sciences Centre, Toronto, ON, Canada
    Lancet 376:1339-46. 2010
    b>Critical care has evolved from treatment of poliomyelitis victims with respiratory failure in an intensive care unit to treatment of severely ill patients irrespective of location or specific technology...
  80. ncbi Attitudes and beliefs related to the Canadian critical care nutrition practice guidelines: an international survey of critical care physicians and dietitians
    Naomi E Cahill
    Kingston General Hospital, Kingston, Ontario, Canada
    JPEN J Parenter Enteral Nutr 34:685-96. 2010
    The objective of this study was to evaluate the attitudes of critical care practitioners toward the Canadian Critical Care Nutrition Clinical Practice Guidelines (CPGs) and compare them with actual practice.
  81. pmc Toll-like receptors 2 and 4: initiators of non-septic inflammation in critical care medicine?
    Emmanuel Lorne
    Pole Anesthésie Réanimation, centre hospitalier universitaire d Amiens, Université Jules Verne de Picardie, Place Victor Pauchet, 80054, Amiens Cedex, France
    Intensive Care Med 36:1826-35. 2010
    ....
  82. ncbi The efficacy and safety of proton pump inhibitors vs histamine-2 receptor antagonists for stress ulcer bleeding prophylaxis among critical care patients: a meta-analysis
    Pei Chin Lin
    Department of Pharmacy, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan
    Crit Care Med 38:1197-205. 2010
    To examine the efficacy and safety of proton pump inhibitors in comparison with histamine-2 receptor antagonists for stress-related upper gastrointestinal bleeding prophylaxis among critical care patients.
  83. ncbi Long-term complications of critical care
    Sanjay V Desai
    Section of Pulmonary Critical Care Medicine, Washington Hospital Center, Washington, DC, USA
    Crit Care Med 39:371-9. 2011
    As critical care advances and intensive care unit mortality declines, the number of survivors of critical illness is increasing. These survivors frequently experience long-lasting complications of critical care...
  84. ncbi Generational considerations in providing critical care education
    Tricia Paterson
    Southeast Baptist Hospital, Baptist Health System, San Antonio, Texas 78222, USA
    Crit Care Nurs Q 33:67-74. 2010
    ..Generational preferences should be considered when developing nursing education and in welcoming and accepting new staff into the culture of the nursing unit...
  85. ncbi Replacement of 24-h creatinine clearance by 2-h creatinine clearance in intensive care unit patients: a single-center study
    Manuel E Herrera-Gutiérrez
    Intensive Care Medicine, Carlos Haya University Hospital, 29018 Malaga, Spain
    Intensive Care Med 33:1900-6. 2007
    ..To estimate the usefulness of 2-h creatinine clearance (CrCl) in the ICU and define variables that may reduce agreement...
  86. ncbi Can physiological variables and early warning scoring systems allow early recognition of the deteriorating surgical patient?
    Brian H Cuthbertson
    Health Services Research Unit and Department of Public Health, University of Aberdeen, Foresterhill, Aberdeen, Aberdeen, Scotland, UK
    Crit Care Med 35:402-9. 2007
    ..We aimed to test the ability of physiologic variables, either alone or in existing early scoring systems, to predict major deterioration in a patient's condition and attempt to derive functions with superior accuracy...
  87. ncbi Recalibration of risk prediction models in a large multicenter cohort of admissions to adult, general critical care units in the United Kingdom
    David A Harrison
    Intensive Care National Audit and Research Centre, London, UK
    Crit Care Med 34:1378-88. 2006
    To assess the performance of published risk prediction models in common use in adult critical care in the United Kingdom and to recalibrate these models in a large representative database of critical care admissions.
  88. ncbi Attitudes towards ethical problems in critical care medicine: the Chinese perspective
    Li Weng
    Medical Intensive Care Unit, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, 100730, People s Republic of China
    Intensive Care Med 37:655-64. 2011
    b>Critical care doctors are frequently faced with clinical problems that have important ethical and moral dimensions...
  89. pmc Translational cognition for decision support in critical care environments: a review
    Vimla L Patel
    Center for Decision Making and Cognition, Department of Biomedical Informatics, Arizona State University, Phoenix, AZ 85004, USA
    J Biomed Inform 41:413-31. 2008
    The dynamic and distributed work environment in critical care requires a high level of collaboration among clinical team members and a sophisticated task coordination system to deliver safe, timely and effective care...
  90. ncbi Modelling the impact of an influenza A/H1N1 pandemic on critical care demand from early pathogenicity data: the case for sentinel reporting
    A Ercole
    Addenbrooke s Hospital, University of Cambridge, Cambridge, UK
    Anaesthesia 64:937-41. 2009
    Projected critical care demand for pandemic influenza H1N1 in England was estimated in this study. The effect of varying hospital admission rates under statistical uncertainty was examined...
  91. ncbi The critical care cascade: a systems approach
    Rishi Ghosh
    Department of Critical Care Medicine, Sunnybrook Health Sciences Centre and the University of Toronto, 2075 Bayview Avenue, Room D108, Toronto, ON M4N 3M5, Canada
    Curr Opin Crit Care 15:279-83. 2009
    ..supports the need for a more seamless and interconnected continuum of patient care for a growing compendium of critical care conditions, starting in the prehospital and emergency department (ED) phases of management and continuing ..
  92. ncbi Distressing situations in the intensive care unit: a descriptive study of nurses' responses
    Heather McClendon
    Riverview Regional Medial Center, Gadsden, Ala, USA
    Dimens Crit Care Nurs 26:199-206. 2007
    Moral distress is a significant stressor for nurses in critical care. Feeling that they are doing the "right thing" is important to nurses, and situations of moral distress can make them question their work...
  93. pmc Integrating palliative and critical care: evaluation of a quality-improvement intervention
    J Randall Curtis
    Division of Pulmonary and Critical Care, Box 359762, Harborview Medical Center, University of Washington, Seattle, WA 98104, USA
    Am J Respir Crit Care Med 178:269-75. 2008
    ..Palliative care in the intensive care unit (ICU) is an important focus for quality improvement...
  94. ncbi Accuracy of ultrasonography performed by critical care physicians for the diagnosis of DVT
    Pierre D Kory
    Beth Israel Medical Center, Division of Pulmonary, Critical Care and Sleep Medicine, 7th Floor, Dazian Bldg, 16th St and 1st Ave, New York, NY 10003, USA
    Chest 139:538-42. 2011
    ....
  95. ncbi Obstetric critical care: a blueprint for improved outcomes
    Gerda G Zeeman
    Department of Obstetrics and Gynecology, University Medical Center, Groningen, The Netherlands
    Crit Care Med 34:S208-14. 2006
    ..This may be related to the pregnancy itself, aggravation of a preexisting illness, or complications of the (operative) delivery...
  96. ncbi Student learning outcomes after integration of quality and safety education competencies into a senior-level critical care course
    Connie L Miller
    University of Nebraska Medical Center, College of Nursing, Omaha, Nebraska 68198 5330, USA
    J Nurs Educ 48:678-85. 2009
    ..Results suggest a combination of classroom and clinical learning activities have the strongest impact on student knowledge, skills, and attitudes related to safety and quality...
  97. ncbi Clinical relevance of pharmacokinetics and pharmacodynamics in cardiac critical care patients
    Federico Pea
    Institute of Clinical Pharmacology and Toxicology, Department of Experimental and Clinical Pathology and Medicine, Medical School, University of Udine, Udine, Italy
    Clin Pharmacokinet 47:449-62. 2008
    ..In cardiac critical care patients, various pathophysiological conditions may significantly alter the pharmacokinetic behaviour of drugs...
  98. ncbi Improving verbal communication in critical care medicine
    Peter G Brindley
    Division of Critical Care Medicine, University of Alberta, Edmonton, Alberta, Canada
    J Crit Care 26:155-9. 2011
    ..Therefore, this article offers practical strategies borrowed from aviation and applied to critical care medicine...
  99. pmc Modelling the impact of local reactive school closures on critical care provision during an influenza pandemic
    Thomas House
    Warwick Mathematics Institute, University of Warwick, Gibbet Hill Road, Coventry CV4 7AL, UK
    Proc Biol Sci 278:2753-60. 2011
    ....
  100. ncbi Critical care and transfusion management in maternal deaths from postpartum haemorrhage
    Marie Pierre Bonnet
    INSERM, UMR S953, Epidemiological Research Unit on Perinatal Health and Women s and Children s Health, Hopital Tenon, Paris, France
    Eur J Obstet Gynecol Reprod Biol 158:183-8. 2011
    ..The aim of this study was to describe critical care management, particularly transfusion practices, in cases of maternal deaths from PPH.
  101. ncbi Targeted temperature management in critical care: a report and recommendations from five professional societies
    Mark E Nunnally
    University of Chicago, Chicago, IL, USA
    Crit Care Med 39:1113-25. 2011
    Representatives of five international critical care societies convened topic specialists and a nonexpert jury to review, assess, and report on studies of targeted temperature management and to provide clinical recommendations.

Research Grants75

  1. ONCOTIC PRESSURE AND EXTRAVASCULAR LUNG WATER IN ARDS
    Gregory Martin; Fiscal Year: 2004
    ..Expertise in these areas will provide the necessary components for a successful career in patient-oriented critical care research...
  2. ASTHMA CLINICAL RESEARCH NETWORK (ACRN)
    Stephen Peters; Fiscal Year: 2007
    ..and basic scientific resources located at Wake Forest University (WFU), in the Division of Pulmonary and Critical Care Medicine, the Cloverdale Pulmonary Clinical Research Center, the Center for Human Genomics, and the Department ..
  3. Endotoxin, the airway transcriptome, and obstructive lung disease
    PEGGY SUE LAI; Fiscal Year: 2013
    ..and an intense clinical focus, and has an outstanding history of mentorship, leadership in pulmonary and critical care medicine, and clinical excellence...
  4. Characterizing TLR Function of Human Dendritic Cells in the Elderly
    Alexander Panda; Fiscal Year: 2012
    ..candidate is a physician trained in Internal Medicine and Infectious Diseases who is a fellow in Pulmonary and Critical Care Medicine and a Ph.D. candidate in the Investigative Medicine Program at the Yale University School of Medicine...
  5. Evaluation of obstructive sleep apnea with long range 3D endoscopic FDOCT
    Jun Zhang; Fiscal Year: 2013
    ..in the study of development of new laser diagnostic technologies for translation to clinical pulmonary and critical care medicine. Co-mentor Dr...
  6. SARS-CoV Pathogenic Mechanisms in Senescent Mice
    Ralph S Baric; Fiscal Year: 2012
    ..approaches 50%, effects ~1,000,000 people/year worldwide, and ranks among the most difficult challenges in critical care medicine...
  7. Genetic Epidemiology of Life-Threatening Influenza Infection in Children
    Adrienne Randolph; Fiscal Year: 2009
    ..infection (LRTI) in children with acute respiratory failure, designed by an established group of pediatric critical care clinical trial investigators, was developed to evaluate how the host innate immune response is associated with ..
  8. Metabolic Dysfunction and Neuroprotection after Pediatric Head Injury
    Susanna Scafidi; Fiscal Year: 2013
    ..that will greatly promote the candidate's career as a clinician/investigator in the field of pediatric critical care. PUBLIC HEALTH RELEVANCE: TBI is a leading cause of death and long-term disability in children in United ..
  9. Mechanisms and Consequences of Intermittent Hypoxia-Induced Lipolysis
    Jonathan C Jun; Fiscal Year: 2013
    ..Jonathan Jun recently completed a 5-year fellowship at Johns Hopkins in Pulmonary, Critical Care, and Sleep Medicine. He has been working in the laboratory of Dr...
  10. Effect of Ultrafiltration on Clinical Outcomes and Health-related Quality of Life
    KELLY VICTORIA LIANG; Fiscal Year: 2013
    ..Teuteberg);Psychiatry, Psychology, Epidemiology and Biostatistics (Dr. Dew);Biostatistics (Dr. Weissfeld);and Critical Care Medicine (Dr. Kellum)...
  11. Predictors of sleep-dependent Memory Consolidation in Obstructive Sleep Apnea
    Ina E Djonlagic; Fiscal Year: 2013
    ..Dr. Malhotra is trained in pulmonary, critical care, and sleep medicine, and is internationally known for his research in sleep- related respiratory physiology...
  12. Monitoring of Cardiovascular Function in Infants By Transcutaneous Dye Dilution
    Istvan Seri; Fiscal Year: 2013
    ..Aim 3 is to test the probe in neonates and infants in the Newborn and Infant Critical Care Unit at Children's Hospital Los Angeles and compare CO values with those obtained by functional ..
  13. Best Management of Sigmoid Volvulus: a Prospective Randomized Trial
    JONATHAN CHARLES SAMUEL; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Dr Jonathan Samuel is a rising surgical critical care fellow and currently completing his general surgery residency at the Department of Surgery at the University of North Carolina (UNC)...
  14. Mechanisms to restrain social cheating from quorum sensing in Pseudomonas aerugin
    AJAI DANDEKAR; Fiscal Year: 2013
    ..I recently transitioned from fellow to Acting Instructor of Pulmonary and Critical Care Medicine at the University of Washington (UW) and am conducting research in the lab of E...
  15. The function and regulation of IL-33 in the airway epithelium in asthma
    ERIN D GORDON; Fiscal Year: 2013
    ..This allowed me to begin fellowship in Pulmonary Critical Care at UCSF early and spend additional years performing research...
  16. Functional Genomics Approach to the Role of the JAK/STAT and MAPK Pathway in CBD
    Li Li; Fiscal Year: 2013
    ..three year training plan for the candidate to become an independent scientist in academic pulmonary and critical care medicine. The candidate earned her Ph.D...
  17. The Role of Lung Volumes in Nocturnal Asthma
    ROBERT LLEWELLYN OWENS; Fiscal Year: 2013
    ..Owens, MD is a clinical and research fellow in the Divisions of Sleep and Pulmonary/Critical Care Medicine at the Brigham and Women's Hospital...
  18. Age-dependent microglial responses in hypoxia-ischemia
    PETER A FERRAZZANO; Fiscal Year: 2013
    ..to cerebral ischemia is rooted in my clinical experience caring for children with brain injury as a Pediatric Critical Care Physician...
  19. Modulation of Genes Responsible for Cilia Length by Exposure to Cigarette Smoke
    Ann E Tilley; Fiscal Year: 2013
    ..I am an Assistant Professor of Genetic Medicine and of Medicine, Division of Pulmonary and Critical Care Medicine, at Weill Cornell Medical College. I have been working in Dr. Ronald G...
  20. MULTIDISCIPLINARY TRAINING IN PULMONARY RESEARCH
    MARK WALTER FRAMPTON; Fiscal Year: 2013
    ..including cell and molecular biology, immunology, microbiology, toxicology, biochemistry, pulmonary and critical care medicine, infectious diseases, neonatology, and imaging sciences...
  21. Aromatase Inhibitors in Pulmonary Vascular Complications of Liver Disease
    Steven M Kawut; Fiscal Year: 2013
    ..There are outstanding resources at Penn housed in the Cardiovascular Institute, the Pulmonary, Allergy, and Critical Care Division, and the Center for Clinical Epidemiology and Biostatistics available to the candidate and his ..
  22. Modulating Secondary Damage Following Traumatic Brain Injury in the Child
    Stuart H Friess; Fiscal Year: 2013
    ..Stuart Friess is an Assistant Professor of Anesthesiology and Critical Care Medicine at the University of Pennsylvania (UPENN) and a Pediatric Critical Care Medicine Attending Physician ..
  23. Genetic Epidemiology of Life-Threatening Influenza in Children
    Adrienne G Randolph; Fiscal Year: 2013
    ..This study of life-threatening influenza infection in children, designed by an established group of pediatric critical care clinical trial investigators and being conducted during an influenza pandemic, evaluates how the host innate ..
  24. TREM-1 in Lung Immune Response
    Ruxana T Sadikot; Fiscal Year: 2013
    ..in critically ill patients and the Department of Veterans Affairs is the largest worldwide single provider of critical care services...
  25. HALF-PINT: Heart and Lung Failure - Pediatric INsulin Titration trial - CCC
    Vinay M Nadkarni; Fiscal Year: 2013
    ..will have a significant impact on public health in that its results will inform the broad practice of pediatric critical care nationally by providing evidence-based guidance regarding this critically important and controversial issue.
  26. Molecular Control of Gut Permeability in Trauma
    Mack H Wu; Fiscal Year: 2013
    ..Despite the improved critical care and wound management, posttraumatic complications remain a life-threatening problem that causes extended ..
  27. Age-associated Toll-like receptor dysfunction in the lungs
    Carlos J Orihuela; Fiscal Year: 2010
    ..is a leading cause of death among the elderly (>65 years);despite access to antimicrobials and supportive critical care, the case-fatality rate for elderly with CAP is 15-30%...
  28. Prompt Diagnosis and Treatment of Subclinical Seizures After Cardiac Arrest
    Alexis A Topjian; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Dr. Alexis Ann Topjian, Assistant Professor of Anesthesia, Critical Care, and Pediatrics at the University of Pennsylvania (UPenn), and the Children's Hospital of Philadelphia (CHOP), is ..
  29. Characterization of the Mechanisms Responsible for Sex Based Outcome Difference F
    JASON LEE SPERRY; Fiscal Year: 2013
    ..career goal is to successfully lead clinical and translational research in the field of traumatic injury and critical care, with the overall intent to improve our understanding of the mechanisms which drive the inflammatory cascade ..
  30. Rapid, Low-Cost Cell-Sorting System for Diagnosis of Candidemia
    Scott Irwin; Fiscal Year: 2010
    ..Hospital-acquired infections occur in ~10% of the patients in critical care facilities in the US, and Candida species are currently the 4th leading cause of blood stream infection...
  31. Effectiveness of ICP Monitoring in Pediatric Traumatic Brain Injury
    TELLEN BENNETT; Fiscal Year: 2013
    ..Dr. Bennett is an Assistant Professor of Pediatric Critical Care at the University of Utah...
  32. Using Vessel Caliber to Assess Cardiac Impairment in COPD
    Carolyn E Come; Fiscal Year: 2013
    ..This work will be performed in the Division of Pulmonary and Critical Care Medicine at Brigham and Women's Hospital, a core teaching hospital of Harvard Medical School...
  33. Hypercapnia and neutrophil function in pulmonary host defense
    Khalilah L Gates; Fiscal Year: 2013
    ..Permissive/therapeutic hypercapnia" has been proposed in the critical care setting for the treatment of acute respiratory distress syndrome (ARDS)...
  34. Airway epithelial repair in chronic bronchitis: novel signaling mechanisms
    Andreas Schmid; Fiscal Year: 2013
    ..The principal investigator is a fully clinically trained pulmonary / critical care medicine physician with 30 months postdoctoral training in airway epithelial cell biology...
  35. Airway epithelial repair in chronic bronchitis: novel signaling mechanisms
    Andreas Schmid; Fiscal Year: 2011
    ..The principal investigator is a fully clinically trained pulmonary / critical care medicine physician with 30 months postdoctoral training in airway epithelial cell biology...
  36. Mitochondrial biogenesis in sepsis-induced organ dysfunction
    Karen E Welty-Wolf; Fiscal Year: 2012
    ..mononuclear cells (PBMC) predicts organ dysfunction in non-diabetic and diabetic septic patients, especially critical care myopathy. Specific Aim 2...
  37. Gram-Negative Pneumonia and Lipopolysaccharide Binding Protein
    MARK RICHARD HEMMILA; Fiscal Year: 2010
    ..is designed as a training program for the development of an academic career in Trauma Surgery and Surgical Critical Care. The program builds on prior research experiences and ultimately leads to a career of independent medical ..
  38. HALF-PINT: Heart And Lung Failure - Pediatric INsulin Titration trial - DCC
    David Wypij; Fiscal Year: 2013
    ..will have a significant impact on public health in that its results will inform the broad practice of pediatric critical care nationally by providing evidence-based guidance regarding this critically important and controversial issue.
  39. The Impact of Zinc on Innate Immunity and Patient Safety in Sepsis
    BETH YVONNE BESECKER; Fiscal Year: 2013
    ..Besecker, M.D. is an Assistant Professor in the Pulmonary and Critical Care Division at The Ohio State University. Dr...
  40. Mechanisms of COPD Subphenotype Development
    MICHAEL BRADLEY DRUMMOND; Fiscal Year: 2013
    ..The Division of Pulmonary and Critical Care Medicine and Johns Hopkins University have a long history of training successful clinical researchers in a ..
  41. In Silico Model for Acute Lung Injury Prediction and Clinical Trial Design
    Ognjen Gajic; Fiscal Year: 2010
    ..and its more severe form, acute respiratory distress syndrome (ARDS) are representative examples of important critical care ailments affecting 200,000 patients each year in the US...
  42. Regulation of neutrophil migration by Activated Protein C
    Minsoo Kim; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Sepsis is a serious medical condition in critical care patients caused by systemic inflammatory response resulting from infection...
  43. Collaborative Pediatric Critical Care Research Network At Children's Hospital of
    Joseph A Carcillo; Fiscal Year: 2013
    ..to determine the incidence and outcome of these sepsis induced MOF phenotypes in the Collaborative Pediatric Critical Care Research Network (CPCCRN) population...
  44. Glycemic control in pediatric critical illness: The Ped-E-Trol trial
    MARK RANSFORD RIGBY; Fiscal Year: 2011
    ..and the adoption or even acceptance of regular approaches to glycemic control has not permeated pediatric critical care as it has in adult ICUs. In fact, routine glycemic control is quite rare in pediatric ICU practice...
  45. Transcriptomics in Traumatic Brain Injury: Relationship to Brain Oxygenation and
    Ava M Puccio; Fiscal Year: 2013
    ..Slowing the progression of secondary injury following a brain injury is the goal of the critical care team, and the use of innovative technology, such as brain oxygenation monitoring may assist in early diagnosis ..
  46. Prognostic &Therapeutic Implications of Breathing Patterns in Acute Lung Injury
    FRANK JOSEPH JACONO; Fiscal Year: 2013
    ..Often these patients require care in an intensive care unit (ICU), contributing to a heavy economic burden as critical care consumes approximately 1% of the U.S. gross domestic product...
  47. A new smart neonatal incubator for real-time detection of sepsis
    De Ann M Pillers; Fiscal Year: 2013
    ..Research engineers will address technical aspects of non-invasive breath biomarker measurements in infants in critical care incubators, and determine the carbon delta value for detecting acute inflammation/infection in neonates born ..
  48. Regulation of cellular metabolism by EglN dioxygenases
    Benjamin A Olenchock; Fiscal Year: 2013
    ..He has completed clinical training in Cardiovascular Medicine and Critical Care Medicine through American Board of Internal Medicine accelerated research pathway...
  49. MMDx: A rapid multiplexed matrix code diagnostic for real time epidemiology
    Lee Gehrke; Fiscal Year: 2013
    ..This proposal describes the design, construction, and testing of a novel diagnostic for concurrent detection of multiple pathogens in a setting where no specialized equipment or expertise is required. ..
  50. Molecular Biology and Gene Therapy in Burns and Trauma
    Lyle L Moldawer; Fiscal Year: 2013
    ..They will also be expected to attend clinical seminars, including Surgery and Critical Care Medicine Grand Rounds...
  51. TRAINING IN TRAUMA AND BURN RESEARCH
    RICHARD LOUIS GAMELLI; Fiscal Year: 2013
    ..seven principle investigators, four additional scientific faculty, five clinical specialists in trauma and critical care, eight post-doctoral fellows (both MDs and Ph.D...
  52. Cholinergic regulation of NF-kB in sepsis
    Luis Ulloa; Fiscal Year: 2012
    ..Sepsis is not only related to infections. Shock, trauma, hemorrhage, and other conditions of critical care contribute to severe sepsis, which is characterized by an overwhelming systemic inflammatory response that ..
  53. Biomarkers of Vasospasm and Outcome following Subarachnoid Hemorrhage
    Sherry Hsiang Yi Chou; Fiscal Year: 2013
    ..Despite advances in critical care for SAH patients, more than half of SAH survivors still live with significant disability...
  54. Potential of ICU telemedicine to improve patient safety, reduce morbidity & morta
    JAMES A L MATHERS; Fiscal Year: 2010
    ..The conference will bring together a diverse group of experts in critical care, health services research, health economics, information technology, patient safety and organizational science...
  55. Training in Hantavirus Ecology, Virology & Clinical Investigation in the Americas
    GREGORY JAMES MERTZ; Fiscal Year: 2010
    ..D., MPH, infectious diseases and critical care and post-doctoral fellowship training at the University of New Mexico, the University of Alabama and Southern ..
  56. Standardized Rehabilitation for ICU Patients with Acute Respiratory Failure
    Peter E Morris; Fiscal Year: 2013
    ..Patients with ARF average 15 hospital days with median costs of $30,000. Critical care rehabilitative therapy for patients with ARF is not uniform in its content, timing or the acceptance of its ..
  57. Culturally Adapted Strategies to Enhance Kidney Donation in Native Communities
    Dedra S Buchwald; Fiscal Year: 2013
    ..community events and providing culturally tailored materials to LifeCenter Northwest donation facilitators at critical care hospitals;and 4) survey AI dialysis patients in te Northwest Renal Network to augment our knowledge of kidney ..
  58. Oral Wash for Nucleic Acid Diagnosis and Prognosis of TB in HIV-Infected Ugandans
    JOHN LUCIAN DAVIS; Fiscal Year: 2012
    This is an application for a K23 award for Dr. Lucian Davis, a pulmonary/critical care physician at the University of California, San Francisco (UCSF). Dr...
  59. Critical Care Excellence in Sepsis and Trauma (CREST)
    DEE WALKER contact FORD; Fiscal Year: 2010
    ..A quasi-experimental clinical trial will test the effectiveness of the Critical Care Excellence in Sepsis and Trauma Program (CREST)...
  60. Mechanisms and Antigen Identification in a Novel Model of Autoimmune Lung Disease
    Anthony Shum; Fiscal Year: 2013
    ..As a pulmonary and critical care physician at the University of California, San Francisco, Dr...
  61. Second Generation Small Molecule Inhibitors of Botulinum Neurotoxins
    Sina Bavari; Fiscal Year: 2013
    ..the neuronal cytosol - at this time the only treatment option is impractical mechanical ventilation in a critical care setting...
  62. Gut Circadian Clock and Melatonin Dynamics Following Major Thermal Injury
    Walid M Al Ghoul; Fiscal Year: 2013
    ..an ICU sepsis patient costs six times as much to treat as a non-sepsis patient (The Surviving Sepsis Campaign, Critical Care 7(1), 2003)...
  63. A Protective Role for Fibroblast Activation Protein (FAP) in Pulmonary Fibrosis
    Ming Hui Fan; Fiscal Year: 2013
    ..training program designed to facilitate transition to an academic physician- scientist career in Pulmonary and Critical Care Medicine...
  64. Adenosine and TLR regulation of costimulatory molecule expression in sepsis
    Catherine Valentine; Fiscal Year: 2013
    ..The combination of my background in Infectious Disease and Critical Care medicine gives me unique perspective from which to study the clinical problem of sepsis...
  65. SURGICAL STUDIES OF SEVERE RESPIRATORY FAILURE
    Joseph Zwischenberger; Fiscal Year: 2004
    ..in the United States, and is still associated with a 40 degrees about mortality despite recent advances in critical care. Unfortunately, mechanical ventilation targeted to restore normal blood gases causes high peak airway pressure ..
  66. Feasibility of Measuring Sleep in a Critical Care Environment
    Margaret A Pisani; Fiscal Year: 2010
    ..can begin to examine how sleep disruption, shifts in sleep stages, and alterations in circadian rhythms impact critical care outcomes including delirium...
  67. Clinical Research to Bedside Care: Evidence and Tools for Improving Critical Care
    Gregory J Beilman; Fiscal Year: 2010
    ..The long-term goal of this grant "Clinical Research to Bedside Care: Evidence and Tools for Improving Critical Care" is to evolve the Center for Excellence in Critical Care's very successful industry sponsored Update in ..
  68. Sedation and Psychopharmacology in Critical care
    Marjolein de Wit; Fiscal Year: 2007
    ..D., Assistant Professor of Medicine in the Pulmonary and Critical Care Division at Virginia Commonwealth University, seeks support for this research training in order to establish ..
  69. Supporting New Faculty Recruitment Through Biomedical Research Core Center
    David H Ingbar; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): The University of Minnesota Pulmonary, Allergy, Critical Care &Sleep (PACCS) Division has been systematically recruiting additional physician scientists focused on lung injury and repair to join ..
  70. Facial Expression During Pain
    MAMOONA ARIF; Fiscal Year: 2009
    ..Unfortunately in critical care, many factors alter verbal communication with patients including tracheal incubation, reduced level of ..
  71. DYNAMICS OF ALVEOLAR RECRUITMENT IN LUNG INJURY
    Robert Harris; Fiscal Year: 2005
    ..a background in engineering whose goal is to used those skills to help solve clinical problems in an academic critical care environment...
  72. NON-INVASIVE PNEUMOTHORAX DETECTOR
    ALAN GRESZLER; Fiscal Year: 2009
    ..are not possible for emergency squads or battlefield medics and not practical for long-term monitoring of critical care patients...
  73. CEREBRAL BLOOD FLOW AND METABOLISM DURING INFANT CPR
    Charles Schleien; Fiscal Year: 1990
    ..received residency training in Pediatrics and Anesthesiology, and subspeciality training in Pediatric Critical Care Medicine, during which he was instrumental in developing an infant pediatric cardiopulmonary resuscitation (..
  74. CereTom CT for use with a microPET scanner for preclinical PET/CT imaging
    JONATHAN CARNEY; Fiscal Year: 2009
    ..Genetics, Cell Biology and Physiology, Radiology, Medicine, in particular the Pulmonary, Allergy, and Critical Care Division, as well as the Center for Vaccine Research and the University of Pittsburgh Cancer Institute...
  75. New Faculty Recruitment to Enhance Sleep Disorders Research Program
    Jesse B Hall; Fiscal Year: 2010
    ..program currently includes 13 tenured or tenure-track faculty members from the Sections of Pulmonary and Critical Care, Endocrinology, Diabetes and Metabolism and Emergency Medicine of the Department of Medicine, from the ..