spinal fusion

Summary

Summary: Operative immobilization or ankylosis of two or more vertebrae by fusion of the vertebral bodies with a short bone graft or often with diskectomy or laminectomy. (From Blauvelt & Nelson, A Manual of Orthopaedic Terminology, 5th ed, p236; Dorland, 28th ed)

Top Publications

  1. ncbi Complications of posterior cervical plating
    J G Heller
    Department of Orthopaedics, Emory University School of Medicine, Atlanta, Georgia, USA
    Spine (Phila Pa 1976) 20:2442-8. 1995
  2. pmc Surgical versus nonsurgical treatment for lumbar degenerative spondylolisthesis
    James N Weinstein
    Department of Orthopaedics, Dartmouth Medical School, Lebanon, NH, USA
    N Engl J Med 356:2257-70. 2007
  3. ncbi Extreme Lateral Interbody Fusion (XLIF): a novel surgical technique for anterior lumbar interbody fusion
    Burak M Ozgur
    Department of Neurosurgery, University of California, Irvine Medical Center, 101 The City Drive South Bldg 56, Ste 400, Orange, 92868, USA
    Spine J 6:435-43. 2006
  4. ncbi Intraoperative and early postoperative complications in extreme lateral interbody fusion: an analysis of 600 cases
    W Blake Rodgers
    Spine Midwest, Inc, Jefferson City, Missouri, USA
    Spine (Phila Pa 1976) 36:26-32. 2011
  5. ncbi Minimally invasive surgery: lateral approach interbody fusion: results and review
    Jim A Youssef
    Durango Orthopedic Associates, Spine Colorado, Durango, CO, USA
    Spine (Phila Pa 1976) 35:S302-11. 2010
  6. ncbi A radiographic assessment of the ability of the extreme lateral interbody fusion procedure to indirectly decompress the neural elements
    Leonardo Oliveira
    Instituto de Patologia de Coluna, Sao Paulo, Brazil
    Spine (Phila Pa 1976) 35:S331-7. 2010
  7. ncbi A prospective, nonrandomized, multicenter evaluation of extreme lateral interbody fusion for the treatment of adult degenerative scoliosis: perioperative outcomes and complications
    Robert E Isaacs
    Division of Neurosurgery, Duke University Medical Center, Durham, NC, USA
    Spine (Phila Pa 1976) 35:S322-30. 2010
  8. pmc Reporting of industry funded study outcome data: comparison of confidential and published data on the safety and effectiveness of rhBMP-2 for spinal fusion
    Mark A Rodgers
    Centre for Reviews and Dissemination, University of York, UK
    BMJ 346:f3981. 2013
  9. ncbi Spinal fusion in the United States: analysis of trends from 1998 to 2008
    Sean S Rajaee
    Spine Research Foundation, Santa Monica, CA, USA
    Spine (Phila Pa 1976) 37:67-76. 2012
  10. pmc Trends, major medical complications, and charges associated with surgery for lumbar spinal stenosis in older adults
    Richard A Deyo
    Department of Family Medicine, Mail Code FM, Oregon Health and Science University, 3181 SW Sam Jackson Park Rd, Portland, OR 97239, USA
    JAMA 303:1259-65. 2010

Detail Information

Publications395 found, 100 shown here

  1. ncbi Complications of posterior cervical plating
    J G Heller
    Department of Orthopaedics, Emory University School of Medicine, Atlanta, Georgia, USA
    Spine (Phila Pa 1976) 20:2442-8. 1995
    ..This study finds the risk of lateral mass screw insertion to be considerably less than predicted in vitro. The present study reports other complications that were not predicted in laboratory studies...
  2. pmc Surgical versus nonsurgical treatment for lumbar degenerative spondylolisthesis
    James N Weinstein
    Department of Orthopaedics, Dartmouth Medical School, Lebanon, NH, USA
    N Engl J Med 356:2257-70. 2007
    ..Management of degenerative spondylolisthesis with spinal stenosis is controversial. Surgery is widely used, but its effectiveness in comparison with that of nonsurgical treatment has not been demonstrated in controlled trials...
  3. ncbi Extreme Lateral Interbody Fusion (XLIF): a novel surgical technique for anterior lumbar interbody fusion
    Burak M Ozgur
    Department of Neurosurgery, University of California, Irvine Medical Center, 101 The City Drive South Bldg 56, Ste 400, Orange, 92868, USA
    Spine J 6:435-43. 2006
    ..A lateral retroperitoneal, trans-psoas approach to the anterior disc space allows for complete discectomy, distraction, and interbody fusion without the need for an approach surgeon...
  4. ncbi Intraoperative and early postoperative complications in extreme lateral interbody fusion: an analysis of 600 cases
    W Blake Rodgers
    Spine Midwest, Inc, Jefferson City, Missouri, USA
    Spine (Phila Pa 1976) 36:26-32. 2011
    ..Prospective analysis of 600 extreme lateral interbody fusion (XLIF) approach procedures for intraoperative and perioperative complications...
  5. ncbi Minimally invasive surgery: lateral approach interbody fusion: results and review
    Jim A Youssef
    Durango Orthopedic Associates, Spine Colorado, Durango, CO, USA
    Spine (Phila Pa 1976) 35:S302-11. 2010
    ..A retrospective review of patients treated at 2 institutions with anterior lumbar interbody fusion using a minimally invasive lateral retroperitoneal approach, and review of literature...
  6. ncbi A radiographic assessment of the ability of the extreme lateral interbody fusion procedure to indirectly decompress the neural elements
    Leonardo Oliveira
    Instituto de Patologia de Coluna, Sao Paulo, Brazil
    Spine (Phila Pa 1976) 35:S331-7. 2010
    ..Prospective nonrandomized clinical study on the decompressive effect of the extreme lateral interbody fusion (XLIF) procedure...
  7. ncbi A prospective, nonrandomized, multicenter evaluation of extreme lateral interbody fusion for the treatment of adult degenerative scoliosis: perioperative outcomes and complications
    Robert E Isaacs
    Division of Neurosurgery, Duke University Medical Center, Durham, NC, USA
    Spine (Phila Pa 1976) 35:S322-30. 2010
    ..Prospective multicenter nonrandomized institutional review board-approved observational study of clinical and radiographic outcomes of the extreme lateral interbody fusion (XLIF) procedure in adult scoliosis...
  8. pmc Reporting of industry funded study outcome data: comparison of confidential and published data on the safety and effectiveness of rhBMP-2 for spinal fusion
    Mark A Rodgers
    Centre for Reviews and Dissemination, University of York, UK
    BMJ 346:f3981. 2013
    ..published results of industry funded trials of recombinant human bone morphogenetic protein 2 (rhBMP-2) in spinal fusion match underlying trial data by comparing three different data sources: individual participant data, internal ..
  9. ncbi Spinal fusion in the United States: analysis of trends from 1998 to 2008
    Sean S Rajaee
    Spine Research Foundation, Santa Monica, CA, USA
    Spine (Phila Pa 1976) 37:67-76. 2012
    ..Epidemiological study using national administrative data...
  10. pmc Trends, major medical complications, and charges associated with surgery for lumbar spinal stenosis in older adults
    Richard A Deyo
    Department of Family Medicine, Mail Code FM, Oregon Health and Science University, 3181 SW Sam Jackson Park Rd, Portland, OR 97239, USA
    JAMA 303:1259-65. 2010
    ..Comorbidity is common in older patients, so benefits and risks must be carefully weighed in the choice of surgical procedure...
  11. ncbi Safety and effectiveness of recombinant human bone morphogenetic protein-2 for spinal fusion: a meta-analysis of individual-participant data
    Mark C Simmonds
    Centre for Reviews and Dissemination, University of York, York, United Kingdom
    Ann Intern Med 158:877-89. 2013
    ..Recombinant human bone morphogenetic protein-2 (rhBMP-2) is widely used to promote fusion in spinal surgery, but its safety has been questioned...
  12. ncbi Effectiveness and harms of recombinant human bone morphogenetic protein-2 in spine fusion: a systematic review and meta-analysis
    Rongwei Fu
    Oregon Health and Science University and Portland Veterans Affairs Medical Center, Portland, OR 97239, USA
    Ann Intern Med 158:890-902. 2013
    Recombinant human bone morphogenetic protein-2 (rhBMP-2) is used as a bone graft substitute in spinal fusion, which unites (fuses) bones in the spine...
  13. ncbi Dynamically evoked, discrete-threshold electromyography in the extreme lateral interbody fusion approach
    Antoine G Tohmeh
    Northwest Orthopaedic Specialists, Spokane, Washington
    J Neurosurg Spine 14:31-7. 2011
    ..This study was performed to assess the effectiveness of dynamically evoked electromyography (EMG) to detect and prevent neural injury during the XLIF approach...
  14. ncbi Lateral lumbar interbody fusion: clinical and radiographic outcomes at 1 year: a preliminary report
    Amit K Sharma
    Department of Orthopedic Surgery, University of Minnesota, Minneapolis, MN, USA
    J Spinal Disord Tech 24:242-50. 2011
    ..A retrospective review of patients' radiographs and charts...
  15. pmc Anterior cervical discectomy with fusion in patients with cervical disc degeneration: a prospective outcome study of 258 patients (181 fused with autologous bone graft and 77 fused with a PEEK cage)
    Bjarne Lied
    Department of Neurosurgery Rikshospitalet, Oslo University Hospital, N 0027 Oslo, Norway
    BMC Surg 10:10. 2010
    ....
  16. ncbi 2001 Volvo Award Winner in Clinical Studies: Lumbar fusion versus nonsurgical treatment for chronic low back pain: a multicenter randomized controlled trial from the Swedish Lumbar Spine Study Group
    P Fritzell
    Department of Orthopedic Surgery, Falun Hospital, 79182 Falun, Sweden
    Spine (Phila Pa 1976) 26:2521-32; discussion 2532-4. 2001
    ..A randomized controlled multicenter study with a 2-year follow-up by an independent observer...
  17. ncbi Biomechanical analysis and review of lateral lumbar fusion constructs
    Andrew Cappuccino
    Buffalo Spine Surgery, Lockport, NY, USA
    Spine (Phila Pa 1976) 35:S361-7. 2010
    ..Biomechanical study and the review of literature on lumbar interbody fusion constructs...
  18. ncbi Adjacent segment disease after lumbar or lumbosacral fusion: review of the literature
    Paul Park
    Department of Neurosurgery, University of Michigan Health System, Ann Arbor, MI 48109 0338, USA
    Spine (Phila Pa 1976) 29:1938-44. 2004
    ..Review of the literature...
  19. ncbi Minimally invasive multilevel percutaneous correction and fusion for adult lumbar degenerative scoliosis: a technique and feasibility study
    Neel Anand
    Department of Surgery, Institute for Spinal Disorders, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    J Spinal Disord Tech 21:459-67. 2008
    ..Prospective evaluation of 12 patients undergoing surgery for lumbar degenerative scoliosis...
  20. ncbi The clinical use of enriched bone marrow stem cells combined with porous beta-tricalcium phosphate in posterior spinal fusion
    Yaokai Gan
    Department of Orthopaedics, Shanghai Ninth People s Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, People s Republic of China
    Biomaterials 29:3973-82. 2008
    ..mesenchymal stem cells (MSCs) combined with porous beta-tricalcium phosphate (beta-TCP) was used for posterior spinal fusion in 41 patients...
  21. ncbi Prospective, randomized, multicenter Food and Drug Administration investigational device exemption study of the ProDisc-L total disc replacement compared with circumferential arthrodesis for the treatment of two-level lumbar degenerative disc disease: res
    Rick Delamarter
    The Spine Institute at Saint John s Health Center, 1301 20th Street, Suite 400, Santa Monica, CA 90404, USA
    J Bone Joint Surg Am 93:705-15. 2011
    ..was to determine the twenty-four-month results of a clinical trial of the ProDisc-L total disc replacement as compared with spinal fusion for the treatment of degenerative disc disease at two contiguous vertebral levels from L3 to S1.
  22. pmc A comparison of commercially available demineralized bone matrix for spinal fusion
    Jeffrey C Wang
    Department of Orthopaedics and Traumatology, UCLA School of Medicine, Los Angeles, CA 90024, USA
    Eur Spine J 16:1233-40. 2007
    In an effort to augment the available grafting material as well as to increase spinal fusion rates, the utilization of a demineralized bone matrix (DBM) as a graft extender or replacement is common...
  23. ncbi Electromyographic monitoring and its anatomical implications in minimally invasive spine surgery
    Juan S Uribe
    Department of Neurosurgery and Brain Repair, University of South Florida, Tampa, FL, USA
    Spine (Phila Pa 1976) 35:S368-74. 2010
    ..Literature review...
  24. ncbi A prospective, randomized, multicenter Food and Drug Administration investigational device exemptions study of lumbar total disc replacement with the CHARITE artificial disc versus lumbar fusion: part I: evaluation of clinical outcomes
    Scott Blumenthal
    Texas Back Institute, Plano, Texas 75093, USA
    Spine (Phila Pa 1976) 30:1565-75; discussion E387-91. 2005
    ..A prospective, randomized, multicenter, Food and Drug Administration-regulated Investigational Device Exemption clinical trial...
  25. ncbi Adult spinal deformity surgery: complications and outcomes in patients over age 60
    Michael D Daubs
    Washington University School of Medicine and Department of Orthopedics, St Louis, MO 63110, USA
    Spine (Phila Pa 1976) 32:2238-44. 2007
    ..A retrospective analysis, including prospectively collected patient outcomes data...
  26. ncbi Adult deformity correction through minimally invasive lateral approach techniques
    Gregory M Mundis
    San Diego Center for Spinal Disorder, La Jolla, CA, USA
    Spine (Phila Pa 1976) 35:S312-21. 2010
    ..Review of the available literature, authors' opinion...
  27. ncbi Changes in coronal and sagittal plane alignment following minimally invasive direct lateral interbody fusion for the treatment of degenerative lumbar disease in adults: a radiographic study
    Frank L Acosta
    Department of Neurological Surgery, Cedars Sinai Medical Center, Los Angeles 90048, USA
    J Neurosurg Spine 15:92-6. 2011
    ..The object of this study was to determine changes in sagittal and coronal plane alignment occurring after direct lateral interbody fusion (DLIF)...
  28. ncbi Early complications of extreme lateral interbody fusion in the obese
    William B Rodgers
    Spine Midwest, Inc, Mary s Medical Plaza Ste, Jefferson City, MO 65101, USA
    J Spinal Disord Tech 23:393-7. 2010
    ..A retrospective review of prospective data of all patients undergoing extreme lateral interbody fusion (XLIF) for degenerative disease of the lumbar and thoracic spine...
  29. ncbi United States trends in lumbar fusion surgery for degenerative conditions
    Richard A Deyo
    Department of Medicine, University of Washington, Seattle, Washington, USA
    Spine (Phila Pa 1976) 30:1441-5; discussion 1446-7. 2005
    ..Retrospective cohort study using national sample administrative data...
  30. ncbi A comprehensive review of the safety profile of bone morphogenetic protein in spine surgery
    David Benglis
    Department of Neurological Surgery, University of Miami Miller School of Medicine, Miami, Florida, USA
    Neurosurgery 62:ONS423-31; discussion ONS431. 2008
    ..In this review, we provide the reader with a historical perspective on BMP, current and past research to support its use in spinal procedures, and a critical analysis of the complications reported thus far...
  31. ncbi Polyetheretherketone as a biomaterial for spinal applications
    Jeffrey M Toth
    Department of Orthopaedic Surgery, Medical College of Wisconsin, 9200 W Wisconsin Ave, Box 26099, Milwaukee, WI 53226 0099, USA
    Biomaterials 27:324-34. 2006
    Threaded lumbar interbody spinal fusion devices (TIBFD) made from titanium have been reported to be 90% effective for single-level lumbar interbody fusion, although radiographic determination of fusion has been intensely debated in the ..
  32. ncbi Increase of pullout strength of spinal pedicle screws with conical core: biomechanical tests and finite element analyses
    Ching Chi Hsu
    Department of Mechanical Engineering, National Taiwan University of Science and Technology, Taipei 106, Taiwan
    J Orthop Res 23:788-94. 2005
    ....
  33. ncbi Prevalence, complications, and hospital charges associated with use of bone-morphogenetic proteins in spinal fusion procedures
    Kevin S Cahill
    Department of Neurosurgery, Brigham and Women s Hospital, PBB 3, 75 Francis St, Boston, MA 02115, USA
    JAMA 302:58-66. 2009
    No national data exist to examine use of bone-morphogenetic proteins (BMPs) in spinal fusion surgery.
  34. ncbi Surgical complications of posterior lumbar interbody fusion with total facetectomy in 251 patients
    Shinya Okuda
    Department of Orthopaedic Surgery, Osaka Rosai Hospital, Osaka, Japan
    J Neurosurg Spine 4:304-9. 2006
    ..The purpose of the present study was to examine rates of intraoperative and postoperative complications of PLIF using a large number of cases with uniform instrumentation and a uniform fusion technique...
  35. ncbi Chronic low back pain and fusion: a comparison of three surgical techniques: a prospective multicenter randomized study from the Swedish lumbar spine study group
    Peter Fritzell
    Department of Orthopedic Surgery, Falun Hospital, Falun, Sweden
    Spine (Phila Pa 1976) 27:1131-41. 2002
    ..A multicenter randomized study with a 2-year follow-up period and an independent observer was conducted...
  36. ncbi Lateral mass screw-rod fixation of the cervical spine: a prospective clinical series with 1-year follow-up
    H Gordon Deen
    Department of Neurosurgery, Mayo Clinic Jacksonville, Jacksonville, FL 32224, USA
    Spine J 3:489-95. 2003
    ....
  37. ncbi Influence of acute shortening on the spinal cord: an experimental study
    Norio Kawahara
    Department of Orthopaedic Surgery, School of Medicine, Kanazawa University, Kanazawa, Ishikawa, Japan
    Spine (Phila Pa 1976) 30:613-20. 2005
    ..Morphometric changes of the spinal cord and influence on spinal cord-evoked potentials and spinal cord blood flow and postoperative function of hind limbs were studied in various degrees of acute spinal column shortening in dogs...
  38. pmc Subsidence of stand-alone cervical cages in anterior interbody fusion: warning
    Erol Gercek
    McGill University, Montreal, Canada
    Eur Spine J 12:513-6. 2003
    ..At 15 months' follow-up, her cage was broken. Our preliminary results, so far limited in number, represent a serious warning to the proponents of stand-alone cervical cages..
  39. ncbi Use of recombinant human bone morphogenetic protein-2 to achieve posterolateral lumbar spine fusion in humans: a prospective, randomized clinical pilot trial: 2002 Volvo Award in clinical studies
    Scott D Boden
    Emory Spine Center, Atlanta, Georgia, USA
    Spine (Phila Pa 1976) 27:2662-73. 2002
    ..A prospective randomized clinical study was conducted...
  40. ncbi Randomized clinical trial of lumbar instrumented fusion and cognitive intervention and exercises in patients with chronic low back pain and disc degeneration
    Jens Ivar Brox
    Department of Orthopedic Surgery, National Hospital, Oslo, Norway
    Spine (Phila Pa 1976) 28:1913-21. 2003
    ..Single blind randomized study...
  41. ncbi Complications associated with single-level transforaminal lumbar interbody fusion
    Jeffrey A Rihn
    Department of Orthopaedic Surgery, The Rothman Institute, Thomas Jefferson University Hospital, 925 Chestnut Street, Philadelphia, PA 19107, USA
    Spine J 9:623-9. 2009
    ..Concerns remain, however, regarding the clinical efficacy and safety of its use...
  42. pmc Two-year results of interspinous spacer (X-Stop) implantation in 175 patients with neurologic intermittent claudication due to lumbar spinal stenosis
    Johannes Kuchta
    Department of Neurosurgery, MediaParc Clinic, Cologne, Germany
    Eur Spine J 18:823-9. 2009
    ..Functional (upright-) MRI examinations were able to demonstrate the positional-dependent stenosis. If available, fMRI represents the most helpful radiologic examination in assessing the outcome of interspinous spacer implantation...
  43. ncbi Off-label use of bone morphogenetic proteins in the United States using administrative data
    Kevin L Ong
    Exponent Inc, Philadelphia, PA 19104, USA
    Spine (Phila Pa 1976) 35:1794-800. 2010
    ..Epidemiological study using national administrative data...
  44. ncbi The use of poly(L-lactide-co-caprolactone) as a scaffold for adipose stem cells in bone tissue engineering: application in a spinal fusion model
    Pieter Paul A Vergroesen
    Department of Orthopedic Research, VU University Medical Centre, Amsterdam, The Netherlands
    Macromol Biosci 11:722-30. 2011
    ..An in vivo spinal fusion study in a goat model provides a preclinical proof-of-concept for a one-step surgical procedure with ASCs in ..
  45. pmc The diagnosis and management of infection following instrumented spinal fusion
    Iona Collins
    Department of Spinal Surgery, Nuffield Orthopaedic Centre, Windmill Rd, Headington, Oxford OX3 7LD, UK
    Eur Spine J 17:445-50. 2008
    ..Propionibacteria are a common cause of infection and successful eradication of infection cannot be reliably achieved with antibiotics and wound debridement alone...
  46. pmc Stand-alone cage for posterior lumbar interbody fusion in the treatment of high-degree degenerative disc disease: design of a new device for an "old" technique. A prospective study on a series of 116 patients
    Francesco Costa
    Neurosurgery Department, IRCCS Istituto Ortopedico Galeazzi, Milan, Italy
    Eur Spine J 20:S46-56. 2011
    ..This technique is not demanding and can be considered safe and effective, as shown by the excellent clinical and radiological success rates...
  47. ncbi Prospective study of iliac crest bone graft harvest site pain and morbidity
    David H Kim
    Department of Orthopedic Surgery, Tufts University School of Medicine, 125 Parker Hill Avenue, Boston, MA 02120, USA
    Spine J 9:886-92. 2009
    ..The most frequently reported complication associated with graft harvest is chronic pain...
  48. ncbi Surgical treatment of C2 fractures in the elderly: a multicenter retrospective analysis
    Ibrahim Omeis
    Department of Neurosurgery, New York Medical College, Valhalla, NY 10595, USA
    J Spinal Disord Tech 22:91-5. 2009
    ..Multicenter retrospective analysis...
  49. ncbi Operative versus nonoperative management of acute odontoid Type II fractures: a meta-analysis
    Ali Nourbakhsh
    Department of Neurosurgery, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130, USA
    J Neurosurg Spine 11:651-8. 2009
    ..The purpose of this study was to evaluate the feasibility of the criteria described in the literature as the indications for surgery for acute Type II odontoid fractures...
  50. pmc PLIF in thoracolumbar trauma: technique and radiological results
    Rene Schmid
    Department for Trauma Surgery and Sports Medicine, Medical University Innsbruck, Anichstrasse 35, 6020, Innsbruck, Austria
    Eur Spine J 19:1079-86. 2010
    ..So we think that this technique can be an alternative procedure to combined operations regarding the presented radiological results of successful fusion and loss of correction...
  51. ncbi Clinical and radiographic analysis of an optimized rhBMP-2 formulation as an autograft replacement in posterolateral lumbar spine arthrodesis
    John R Dimar
    Leatherman Spine Center, 210 East Gray Street, Suite 900, Louisville, KY 40202, USA
    J Bone Joint Surg Am 91:1377-86. 2009
    ....
  52. pmc Biomechanical comparison of two different concepts for stand alone anterior lumbar interbody fusion
    Philipp Schleicher
    Center for Spinal Surgery and Neurotraumatology, BG Unfallklinik Frankfurt, Friedberger Landstrasse 430, 60389, Frankfurt, Germany
    Eur Spine J 17:1757-65. 2008
    ..Clinical investigation of the test device seems reasonable based on the good results reported here...
  53. ncbi Evaluation of posterolateral spinal fusion using mesenchymal stem cells: differences with or without osteogenic differentiation
    Takashi Nakajima
    Department of Orthopaedic Surgery, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan
    Spine (Phila Pa 1976) 32:2432-6. 2007
    ..An animal study to achieve posterolateral intertransverse process spine fusion using mesenchymal stem cell (MSC)...
  54. pmc The NEtherlands Cervical Kinematics (NECK) trial. Cost-effectiveness of anterior cervical discectomy with or without interbody fusion and arthroplasty in the treatment of cervical disc herniation; a double-blind randomised multicenter study
    Mark P Arts
    Department of Neurosurgery, Medical Center Haaglanden, The Hague, The Netherlands
    BMC Musculoskelet Disord 11:122. 2010
    ..We present the design of the NECK trial, a randomised study on cost-effectiveness of anterior cervical discectomy with or without interbody fusion and arthroplasty in patients with cervical disc herniation...
  55. ncbi Ball tip technique for thoracic pedicle screw placement in patients with adolescent idiopathic scoliosis
    Kota Watanabe
    Department of Advanced Treatment for Spine and Spinal Cord Disorders, Keio University School of Medicine, Tokyo, Japan
    J Neurosurg Spine 13:246-52. 2010
    ..To further enhance the accuracy and safety of TPS placement, the authors developed the ball tip technique...
  56. ncbi Analysis of biomechanical changes after removal of instrumentation in lumbar arthrodesis by finite element analysis
    Ho Joong Kim
    Yonsei Sarang Hospital, Seoul, Korea
    Med Biol Eng Comput 48:703-9. 2010
    ..This study demonstrated that removal of pedicle screws could decrease stiffness of fusion segments, which would reduce the disk stress of adjacent segments...
  57. ncbi No difference in long-term trunk muscle strength, cross-sectional area, and density in patients with chronic low back pain 7 to 11 years after lumbar fusion versus cognitive intervention and exercises
    Anne Froholdt
    Division of Orthopedic Surgery, Department of Orthopedics, Oslo University Hospital, Rikshospitalet, PB 4950 Nydalen, 0424 Oslo, Norway
    Spine J 11:718-25. 2011
    ..Reduced muscle strength and density observed at 1 year after lumbar fusion may deteriorate more in the long term...
  58. ncbi Direct lateral lumbar interbody fusion for degenerative conditions: early complication profile
    Reginald Q Knight
    Orthopedics International Spine, Kirkland, WA, USA
    J Spinal Disord Tech 22:34-7. 2009
    ..Adverse events: new complaints and increasing length of stay limit early mobilization and require consultation with other physicians or reoperation. These formed the focus of the study...
  59. ncbi Prospective, randomized, multicenter study of cervical arthroplasty: 269 patients from the Kineflex|C artificial disc investigational device exemption study with a minimum 2-year follow-up: clinical article
    Domagoj Coric
    Carolina Neurosurgery and Spine Associates, Charlotte, North Carolina, USA
    J Neurosurg Spine 15:348-58. 2011
    ..This prospective, randomized, multicenter study evaluates the safety and efficacy of a new metal-on-metal CTDR implant (Kineflex|C) by comparing it with ACDF in the treatment of single-level spondylosis with radiculopathy...
  60. ncbi An anatomical study of the lumbosacral plexus as related to the minimally invasive transpsoas approach to the lumbar spine
    David M Benglis
    Department of Neurological Surgery, University of Miami Miller School of Medicine, Miami, Florida, USA
    J Neurosurg Spine 10:139-44. 2009
    ....
  61. ncbi Lumbar instrumented fusion compared with cognitive intervention and exercises in patients with chronic back pain after previous surgery for disc herniation: a prospective randomized controlled study
    Jens Ivar Brox
    Department of Orthopedics and Physiotherapy, Rikshospitalet University Hospital and Medical Faculty University in Oslo, Norway
    Pain 122:145-55. 2006
    ..For patients with chronic low back pain after previous surgery for disc herniation, lumbar fusion failed to show any benefit over cognitive intervention and exercises...
  62. ncbi The relationship of intrapsoas nerves during a transpsoas approach to the lumbar spine: anatomic study
    Daniel K Park
    Rush University Medical Center, Chicago, IL 60612, USA
    J Spinal Disord Tech 23:223-8. 2010
    ..A cadaveric study...
  63. ncbi A prospective, randomized, multicenter Food and Drug Administration investigational device exemption study of lumbar total disc replacement with the CHARITE artificial disc versus lumbar fusion: part II: evaluation of radiographic outcomes and correlation
    Paul C McAfee
    Spine and Scoliosis Center, St Joseph s Hospital, Baltimore, Maryland, USA
    Spine (Phila Pa 1976) 30:1576-83; discussion E388-90. 2005
    ..A prospective, randomized, multicenter, Food and Drug Administration-regulated, investigational device exemption clinical trial...
  64. ncbi The surgical management of degenerative lumbar spondylolisthesis: a systematic review
    C Ryan Martin
    University of Ottawa, Faculty of Medicine, Ottawa, ON, Canada
    Spine (Phila Pa 1976) 32:1791-8. 2007
    ..Systematic review...
  65. ncbi Minimally invasive lateral retropleural thoracolumbar approach: cadaveric feasibility study and report of 4 clinical cases
    Juan S Uribe
    Department of Neurological Surgery, University of South Florida, Tampa, Florida, USA
    Neurosurgery 68:32-9; discussion 39. 2011
    ..Traditional anterior and posterior approaches to the thoracolumbar spine are associated with significant morbidity. In an effort to eliminate these drawbacks, minimally invasive retropleural approaches have been developed...
  66. ncbi Clinical outcomes of the Dynesys dynamic neutralization system: 1-year preliminary results
    William C Welch
    University of Pittsburgh Medical Center Health System, Presbyterian University Hospital, Pittsburgh, Pennsylvania 15213 2582, USA
    Neurosurg Focus 22:E8. 2007
    ....
  67. ncbi Complications of lateral plating in the minimally invasive lateral transpsoas approach
    Tien V Le
    Department of Neurosurgery and Brain Repair, University of South Florida, Tampa, Florida 33606, USA
    J Neurosurg Spine 16:302-7. 2012
    ..Three cases of hardware failure and 3 cases of vertebral body (VB) fractures associated with lateral plate placement are reported. The authors also review the literature pertaining to lateral plates and related complications...
  68. ncbi Parathyroid hormone (1-34) augments spinal fusion, fusion mass volume, and fusion mass quality in a rabbit spinal fusion model
    Padhraig F O'Loughlin
    Hospital for Special Surgery, New York, New York 10021, USA
    Spine (Phila Pa 1976) 34:121-30. 2009
    The posterolateral rabbit spinal fusion model was used to assess the effect of intermittent parathyroid hormone on spinal fusion outcomes.
  69. ncbi The indications for lumbar spinal fusion with and without instrumentation
    E N Hanley
    Department of Orthopaedic Surgery, Carolinas Medical Center, Charlotte, North Carolina, USA
    Spine (Phila Pa 1976) 20:143S-153S. 1995
    ..OBJECTIVES: A review, analysis, and discussion of the extensive literature on lumbar spinal fusion were done to attempt to place in perspective the indications and success rate for lumbar spinal fusion with ..
  70. pmc Total disc replacement compared to lumbar fusion: a randomised controlled trial with 2-year follow-up
    Svante Berg
    Stockholm Spine Center, Löwenströmska Hospital, 19489, Upplands Vasby, Sweden
    Eur Spine J 18:1512-9. 2009
    ..The main objective of this study is to compare TDR with lumbar spinal fusion, in terms of clinical outcome, in patients referred to a spine clinic for surgical evaluation...
  71. pmc Cervical disc herniation and cervical spondylosis surgically treated by Cloward procedure: a 10-year-minimum follow-up study
    Cesare Faldini
    Department of Orthopaedic Surgery, Istituto Ortopedico Rizzoli, University of Bologna, Via G Pupilli 1, 40136, Bologna, Italy
    J Orthop Traumatol 11:99-103. 2010
    ....
  72. pmc Factors affecting sagittal malalignment due to cage subsidence in standalone cage assisted anterior cervical fusion
    Pavel Barsa
    Department of Neurosurgery, Regional Hospital of Liberec, Husova str 10, 46063 Liberec, Czech Republic
    Eur Spine J 16:1395-400. 2007
    ..The significance of implant subsidence in acceleration of degenerative changes in adjacent segments remains to be evaluated during a longer follow-up...
  73. ncbi Percutaneous axial lumbar interbody fusion (AxiaLIF) of the L5-S1 segment: initial clinical and radiographic experience
    H E Aryan
    Department of Neurosurgery, University of California San Francisco, CA, USA
    Minim Invasive Neurosurg 51:225-30. 2008
    ..We reviewed our experience with a novel minimally invasive technique for L5-S1 interbody fusion that exploits the presacral space and its relative dearth of critical structures...
  74. ncbi Dynamic neutralization of the lumbar spine after microsurgical decompression in acquired lumbar spinal stenosis and segmental instability
    Carola C Würgler-Hauri
    Department of Neurosurgery, Kantonsspital Aarau, Aarau, Switzerland
    Spine (Phila Pa 1976) 33:E66-72. 2008
    ..Prospective clinical study...
  75. ncbi Adjacent segment mobility after rigid and semirigid instrumentation of the lumbar spine
    Balkan Cakir
    Department of Orthopaedic Surgery, University of Ulm, Ulm, Germany
    Spine (Phila Pa 1976) 34:1287-91. 2009
    ..Retrospective radiographic analysis of lumbar spine range of motion (ROM) after monosegmental fusion and posterior dynamic stabilization at the level L4-L5...
  76. ncbi Disc changes in the bridged and adjacent segments after Dynesys dynamic stabilization system after two years
    Abhishek Kumar
    Department of Orthopaedic Surgery, Woodend Hospital, Arberdeen, UK
    Spine (Phila Pa 1976) 33:2909-14. 2008
    ..Prospective case series...
  77. ncbi Prospective, randomized, multicenter Food and Drug Administration investigational device exemption study of lumbar total disc replacement with the CHARITE artificial disc versus lumbar fusion: five-year follow-up
    Richard D Guyer
    Texas Back Institute, 6020 West Parker Road, Suite 200, Plano, TX 75093, USA
    Spine J 9:374-86. 2009
    ..No long-term, randomized, prospective study on the CHARITE disc or any other artificial disc has been published to date...
  78. ncbi Reoperation rates following lumbar spine surgery and the influence of spinal fusion procedures
    Brook I Martin
    Department of Medicine, University of Washington, Seattle, WA, USA
    Spine (Phila Pa 1976) 32:382-7. 2007
    ..Retrospective cohort study using a hospital discharge registry of all nonfederal acute care hospitals in Washington state...
  79. ncbi Unilateral versus bilateral pedicle screw fixation in lumbar spinal fusion
    K S Suk
    Department of Orthopaedic Surgery, School of Medicine, Kyung Hee University, Seoul, Korea
    Spine (Phila Pa 1976) 25:1843-7. 2000
    ..whether unilateral pedicle screw fixation is comparable with bilateral fixation in one- or two-segment lumbar spinal fusion. SUMMARY OF BACKGROUND DATA: Clinical results for unilateral variable screw placement instrumentation in ..
  80. ncbi Instrumented and noninstrumented posterolateral fusion in adult spondylolisthesis--a prospective randomized study: part 2
    H Moller
    Department of Orthopaedic Surgery, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden
    Spine (Phila Pa 1976) 25:1716-21. 2000
    ..A prospective randomized study was performed...
  81. ncbi Association of catechol-O-methyltransferase genetic variants with outcome in patients undergoing surgical treatment for lumbar degenerative disc disease
    Feng Dai
    Molecular Epidemiology of Pain Program, Department of Anesthesiology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Spine J 10:949-57. 2010
    ..Genetic variation of the catechol-O-methyltransferase (COMT) gene has been associated with variation in human pain sensitivity and response to analgesics in previous studies...
  82. ncbi Potential large vessel injury during thoracolumbar pedicle screw removal. A case report
    J S Vanichkachorn
    Department of Orthopaedic Surgery, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, USA
    Spine (Phila Pa 1976) 22:110-3. 1997
    ..Instruments designed to capture the end of the distal screw fragment through an interference fit may allow anterior screw migration to occur, particularly in osteoporotic bone...
  83. ncbi A prospective randomized multicenter clinical evaluation of an anterior cervical fusion cage
    R J Hacker
    Oregon Neurosurgery Specialists, Eugene, Oregon 97401, USA
    Spine (Phila Pa 1976) 25:2646-54; discussion 2655. 2000
    ..A prospective, concurrently controlled, randomized, multicenter trial of an anterior Bagby and Kuslich cervical fusion cage (BAK/C; Sulzer Spine-Tech, Minneapolis, MN) for treatment of degenerative disc disease of the cervical spine...
  84. ncbi Anterior cervical discectomy and fusion associated complications
    Kostas N Fountas
    Department of Neurosurgery, Medical Center of Central Georgia, Mercer University, School of Medicine, Macon, GA, USA
    Spine (Phila Pa 1976) 32:2310-7. 2007
    ..Retrospective review study with literature review...
  85. ncbi Lumbar total disc replacement from an extreme lateral approach: clinical experience with a minimum of 2 years' follow-up
    Luiz Pimenta
    Minimally Invasive and Reconstructive Spine Surgery, Instituto de Patologia da Coluna, Sao Paulo, Brazil
    J Neurosurg Spine 14:38-45. 2011
    ..In this study, the authors attempted to quantify the clinical and radiographic outcomes of a lateral approach to lumbar TDR from a prospective, single-center experience...
  86. ncbi The Lumbar I/F Cage for posterior lumbar interbody fusion with the variable screw placement system: 10-year results of a Food and Drug Administration clinical trial
    John W Brantigan
    South Texas Orthopaedic and Spinal Surgery Associates, 9150 Huebner Road, San Antonio, TX 78240, USA
    Spine J 4:681-8. 2004
    ..Based on the 2-year results of this study, the cage was approved by the US Food and Drug Administration (FDA) in February 1999. Since then, the Lumbar I/F Cage device has become widely used in the United States...
  87. ncbi Comparison of anterior and posterior instrumentation for correction of adolescent thoracic idiopathic scoliosis
    R R Betz
    Shriners Hospital, Philadelphia, Pennsylvania, USA
    Spine (Phila Pa 1976) 24:225-39. 1999
    ..METHODS: Seventy-eight patients who underwent an anterior spinal fusion using flexible threaded rods and nuts (Harms-MOSS instrumentation, De Puy-Motech-Acromed, Cleveland, OH) were ..
  88. ncbi The effect of spinal implant rigidity on vertebral bone density. A canine model
    P C McAfee
    Department of Orthopedic Surgery, Johns Hopkins University School of Medicine
    Spine (Phila Pa 1976) 16:S190-7. 1991
    ..Observation 6 months after surgery revealed a significantly improved probability of achieving a spinal fusion if spinal instrumentation had been used (X2 = 5.84, P = .016)...
  89. ncbi Distractive properties of a threaded interbody fusion device. An in vivo model
    H S Sandhu
    Department of Orthopaedic Surgery, UCLA School of Medicine, USA
    Spine (Phila Pa 1976) 21:1201-10. 1996
    ..CONCLUSION. Despite early subsidence, interbody fusion cages successfully distracted and preserved interbody spaces. This model is useful for investigating methods of improving distraction and stabilization...
  90. ncbi Complications of buttress plate stabilization of cervical corpectomy
    K D Riew
    Department of Orthopaedic Surgery, Barnes Jewish Hospital, Washington University School of Medicine, St Louis, Missouri, USA
    Spine (Phila Pa 1976) 24:2404-10. 1999
    ..Surgeons who utilize these types of buttress plates without additional posterior instrumentation should be aware of the potential complications of buttress plate fixation...
  91. ncbi Lumbar fusion in octogenarians: the promise of minimally invasive surgery
    William Blake Rodgers
    Spine Midwest Inc, Jefferson City, MO, USA
    Spine (Phila Pa 1976) 35:S355-60. 2010
    ..Retrospective chart review of prospectively collected data from 2 nonrandomized, nonconcurrent cohorts...
  92. ncbi Accuracy and safety of thoracic pedicle screw placement in spinal deformities
    Yossi Smorgick
    Spine Unit, Department of Orthopedic Surgery, Assaf Harofeh Medical Center, Zerifin, Israel
    J Spinal Disord Tech 18:522-6. 2005
    ..To determine the safety of pedicle screw fixation in thoracic spine deformity correction...
  93. ncbi Anterior cervical interbody fusion with a titanium box cage: early radiological assessment of fusion and subsidence
    Hans Peter W van Jonbergen
    Institute of Spinal Surgery and Applied Research, Sint Maartenskliniek, Hengstdal 3, 6522 JV Nijmegen, The Netherlands
    Spine J 5:645-9; discussion 649. 2005
    ..The use of stand-alone cervical interbody cages in anterior cervical discectomy with fusion (ACDF) has become popular, but high subsidence rates have been reported in the literature...
  94. ncbi Treatment of multilevel cervical spondylotic myeloradiculopathy with posterior decompression and fusion with lateral mass plate fixation and local bone graft
    Russel C Huang
    Hospital for Special Surgery, New York, NY, USA
    J Spinal Disord Tech 16:123-9. 2003
    ..A high rate of improvement of myelopathy was observed, neurologic deterioration did not occur, and complication rates were low. Severe myelopathy and myelomalacia on preoperative MRI had no prognostic value...
  95. ncbi Surgery for lumbar spinal stenosis. Attempted meta-analysis of the literature
    J A Turner
    Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle
    Spine (Phila Pa 1976) 17:1-8. 1992
    ..Few patient characteristics were found to predict outcome. Major deficits in study design, analysis, and reporting were common, and these precluded firm conclusions...
  96. ncbi Thoracic pedicle screw fixation in spinal deformities: are they really safe?
    S I Suk
    Seoul Spine Institute, Inje University Paik Hospital, Seoul, Korea
    Spine (Phila Pa 1976) 26:2049-57. 2001
    ..A retrospective study...
  97. pmc Randomised controlled trial to compare surgical stabilisation of the lumbar spine with an intensive rehabilitation programme for patients with chronic low back pain: the MRC spine stabilisation trial
    Jeremy Fairbank
    Nuffield Orthopaedic Centre, Oxford OX3 7LD
    BMJ 330:1233. 2005
    To assess the clinical effectiveness of surgical stabilisation (spinal fusion) compared with intensive rehabilitation for patients with chronic low back pain.
  98. ncbi Effects of age on the perioperative characteristics and short-term outcome of posterior lumbar fusion surgery
    Cumhur Kilincer
    Department of Neurosurgery, Trakya University Medical Faculty, Edirne, Turkey
    J Neurosurg Spine 3:34-9. 2005
    ..The authors conducted a study to evaluate if increased age has any effect on lumbar fusion surgery in terms of perioperative events...
  99. ncbi Adding posterior lumbar interbody fusion to pedicle screw fixation and posterolateral fusion after decompression in spondylolytic spondylolisthesis
    S I Suk
    Department of Orthopedic Surgery, Seoul National University Hospital, Korea
    Spine (Phila Pa 1976) 22:210-9; discussion 219-20. 1997
    ....
  100. ncbi Results of the prospective, randomized, controlled multicenter Food and Drug Administration investigational device exemption study of the ProDisc-C total disc replacement versus anterior discectomy and fusion for the treatment of 1-level symptomatic cervi
    Daniel Murrey
    OrthoCarolina Spine Center, Charlotte, NC 28207, USA
    Spine J 9:275-86. 2009
    ..Cervical total disc replacement (TDR) is intended to address radicular pain and preserve functional motion between two vertebral bodies in patients with symptomatic cervical disc disease (SCDD)...
  101. ncbi Primary pedicle screw augmentation in osteoporotic lumbar vertebrae: biomechanical analysis of pedicle fixation strength
    Daniel J Burval
    Cleveland Clinic Foundation, Cleveland Clinic Spine Institute, Cleveland, OH 44195, USA
    Spine (Phila Pa 1976) 32:1077-83. 2007
    ..Pedicle screw pullout testing in osteoporotic and control human cadaveric vertebrae, comparing augmented and control vertebrae...

Research Grants62

  1. BBP (Bone Morphogenetic Protein Binding Peptide) and Bone Healing
    SAMUEL SCOTT MURRAY; Fiscal Year: 2013
    ..cBBP increases the tissue retention of BMP-2 and stimulates BMP-2 and BMP-7- mediated spinal fusion and BMP-2-mediated long bone healing...
  2. ADULT STEM CELL SUPPRESSION DUE TO ALCOHOL INDUCED MICROENVIRONMENT ALTERATIONS
    Mandi J Lopez; Fiscal Year: 2010
    ..Posterolateral spinal fusion is the standard treatment for lumbar compression fractures common in ethanol-induced osteoporosis...
  3. Recombinant expression of a biomaterial-targeting BMP-2 containing a peptide tag
    HANNE GRON; Fiscal Year: 2010
    ..powerful initiator of osteogenic activity, and has since become part of a leading orthopedic product used for spinal fusion procedures (InFuse from Medtronic)...
  4. Keratin hydrogel matrix for tunable growth factor delivery in bone regeneration
    Justin Saul; Fiscal Year: 2013
    ..to rapid and uncontrolled release of BMP-2 limit FDA approved applications of this delivery system to lumbar spinal fusion and tibial fracture...
  5. Novel Formulations for Injectable Growth Factors
    Bruce Lamb; Fiscal Year: 2010
    ..factors, particularly bone morphogenetic proteins (BMPs) are employed for a range of indications including spinal fusion and fracture healing due to their potent osteogenic activity (Mont et al. 2004)...
  6. Development of Osteogenic Oxysterols for Local Bone Formation
    Farhad Parhami; Fiscal Year: 2013
    ..mouse calvaria organ cultures, and bone healing in both a rat calvarial critical-sized defect model and a rat spinal fusion model in vivo...
  7. Tissue engineering application of endochondral ossification for bone regeneration
    CHELSEA SHIELDS BAHNEY; Fiscal Year: 2013
    ..a significant unmet need to improve the clinical outcome in procedures treating trauma, fracture non-unions, spinal fusion, osteonecrosis, and segmental bone osteotomies such as those created upon tumor removal...
  8. Biomimetic Scaffold Delivering Osteogenic Molecules for Alveolar Bone Engineering
    Min Lee; Fiscal Year: 2013
    ..In particular, bone morphogenetic proteins (BMPs) are currently approved for spinal fusion, tibial fracture repair, and alveolar ridge or maxillary sinus augmentation...
  9. Back pain Outcomes using Longitudinal Data (BOLD)
    Jeffrey G Jarvik; Fiscal Year: 2010
    ..g. artificial discs, genomics) to widely disseminated mature interventions (e.g. MRI, physical therapy, spinal fusion)...
  10. Biphasic Intervertebral Disc Regeneration using Biomimetic Scaffolds
    Benjamin R Whatley; Fiscal Year: 2012
    ..Current solutions to treat IVD degeneration, which include discectomy, spinal fusion, and the use of artificial disc replacements, do nothing to support natural tissue regeneration and focus only ..
  11. Wear, Inflammation and Clinical Performance of Total Disc Replacement
    STEVEN MICHAEL KURTZ; Fiscal Year: 2013
    ..In the 1960s, total disc replacement (TDR) was conceived as an alternative treatment to spinal fusion and the resulting complications...
  12. Bioactive Peptide Coatings for Synthetic Bone Grafts
    Jonathan A Hodges; Fiscal Year: 2013
    ..In the United States, there are over 500,000 spinal fusion surgeries every year, and the frequency of these surgeries is projected to grow 6% per year...
  13. Integrated Structural BMP2 Carrier Systems for Cervical Spine Fusion
    Frank La Marca; Fiscal Year: 2013
    ..Successful completion of this proposal will provide a new paradigm for bioresorbable fusion systems in the cervical spine, achieving spinal fusion with lower, safer, and less expensive doses of BMP2.
  14. LMP-1 is a critical regulator of BMP signaling and BMP responsiveness
    Scott D Boden; Fiscal Year: 2010
    ..One of the greatest clinical challenges in Orthopaedics is the inability to consistently generate bone for spinal fusion and bone defect reconstruction...
  15. ENHANCEMENT OF LUMBAR FUSION W/ RHBMP 2/ COLLAGEN OR LMP
    Scott D Boden; Fiscal Year: 2011
    ..Lumbar spinal fusion is commonly performed on humans, but the failure of bone union is a frequent complication...
  16. Genetic Analysis of Idiopathic-Type Curvature in Model Teleosts
    Felix Breden; Fiscal Year: 2009
    ..deformity imposes a substantial cost on the healthcare system through physician care, bracing treatments, and spinal fusion surgeries...
  17. Phase 2 Study of the HemiBridge System for the Treatment of Idiopathic Scoliosis
    Joseph Reynolds; Fiscal Year: 2013
    ..Bracing is an attempt to arrest progression and avoid spinal fusion. When the curvature progresses beyond 40[unreadable] or 50[unreadable], a multiple level spinal fusion is the ..
  18. Genetic Determinants of Ankylosing Spondylitis Severity
    Michael Weisman; Fiscal Year: 2005
    ..some having severe persistent joint inflammation, functional limitation, premature work disability, and early spinal fusion. We hypothesize that the severity of -AS is genetically determined, and that genes that influence ..
  19. Implantable Biodegradable RF-Powered Tissue Stimulator and Electrodes
    Lee E Weiss; Fiscal Year: 2012
    ..to electrical specifications and forms that are compatible with their incorporation into a biodegradable spinal fusion stimulator as a paradigm application of this technology...
  20. ANALYSIS AND SIMULATION OF SURGICAL SPINAL FUSION
    Ian Stokes; Fiscal Year: 1993
    ..Results will help to provide guidelines for selection and use of different surgical procedures...
  21. Spinal Fusion Using Adipose Derived Adult Stem Cells
    Jeffrey Gimble; Fiscal Year: 2005
    ..b>Spinal fusion is the orthopedic procedure routinely used to treat back pain in patients suffering from degenerative disc ..
  22. Novel Bone Graft Material With Osteoinductive and Hemostatic Function
    Bo Han; Fiscal Year: 2009
    ..order animal studies in phase II to test the optimal composite for specific functional applications, such as spinal fusion and sternal bone repair...
  23. Organizational Interventions for SSI Prevention in Pediatric Spinal Surgery
    Lisa M McLeod; Fiscal Year: 2013
    ..on the comparative effectiveness of interventions for preventing surgical site infections (SSI) following spinal fusion operations in children, with an emphasis on the association between elements of the organizational contexts of ..
  24. Injectable BMP-2 Formulation for Fracture Healing
    Paul Hamilton; Fiscal Year: 2006
    ..Proteins (BMP's), rhBMP-2 and rhBMP-7, are currently used in clinical applications to promote spinal fusion and fracture healing (Mont, Ragland et al. 2004). Over 6...
  25. AGING AND FUNCTIONAL OUTCOME AFTER SURGERY FOR SDM
    Neil Oldridge; Fiscal Year: 1990
    ..and decompression of the spinal canal structures, excision or destruction of intervertebral disc and spinal fusion, with respect to patient and hospital characteristics, describing and documenting outcomes such as mortality, ..
  26. TISSUE ENGINEERING OF THE INTERVERTEBRAL DISC
    J VRESILOVIC; Fiscal Year: 2001
    ..Current, operative intervention for restoration of spine mechanical function is limited to various spinal fusion techniques for endstage disease with varied result in both short and long term outcome...
  27. TISSUE ENGINEERING OF THE INTERVERTEBRAL DISC
    J VRESILOVIC; Fiscal Year: 2002
    ..Current, operative intervention for restoration of spine mechanical function is limited to various spinal fusion techniques for endstage disease with varied result in both short and long term outcome...
  28. A new absorbable antimicrobial bone graft substitute
    David Martin; Fiscal Year: 2005
    ..Osteomyelitis occurs in an estimated 1-3% of all orthopedic surgeries with the incidence being even higher in spinal fusion and open fractures...
  29. Computer Modeling/Etiological Study of Acute Injury Risk
    TIMOTHY OVAERT; Fiscal Year: 2005
    ..The first area of study will develop computational models of spinal fusion in order to determine the relative importance of fusion mass location, fusion mass size, bone density of the ..
  30. DESIGNED DEGRADABLE INTERBODY CAGES
    Chia Ying Lin; Fiscal Year: 2007
    ..correction and for discogenic axial back pain with or without concomitant radiculopathy is a segmental spinal fusion. Currently, over 250,000 spine fusions are performed yearly in the US...
  31. AAV-mediated gene therapy for metabolic bone disease
    Selvarangan Ponnazhagan; Fiscal Year: 2009
    ..mass of bone per unit volume as in osteoporosis or insufficient mechanisms for anabolic bone remodeling as in spinal fusion and fracture...
  32. Mechanism of Nicotine Action in the Healing Skeleton
    Michael Zuscik; Fiscal Year: 2009
    ..literature that cigarette smoking has a negative impact on healing following long bone fracture and spinal fusion surgery...
  33. Click Chemistry for Immobilized Bone Morphogenetic Protein
    SHRIKUMAR NAIR; Fiscal Year: 2006
    ..growth factors that stimulate new bone production and have received FDA approval for bone fracture repair and spinal fusion. For most clinically approved uses of BMPs, a resorbable collagen sponge is used as the delivery matrix to ..
  34. PDGF-Treated Demineralized Bone Matrix for Spinal Fusion
    Kathy Traianedes; Fiscal Year: 2001
    ..b>Spinal fusion with autologous bone graft is the gold standard procedure for lumbar fusion, for which bone is usually ..
  35. SPINE FUSION SENSOR
    Jan Lewandowski; Fiscal Year: 2001
    ..To evaluate status of spinal fusion we propose a telemetric, implantable device that consists of: (1) strain gauge sensor attached to the ..
  36. Implementation of an Elementary and Robust Implantable Sensor for Musculoskeletal
    Eric H Ledet; Fiscal Year: 2013
    ..The sensors will be integrated into spinal implants to (a) objectively correlate in vivo force to progress of spinal fusion, and (b) quantify real time in vivo multi-axial interbody force (axial and shear) during dynamic activities in ..
  37. Effects of Physiotones on Adolescents' Pain
    Bernice Mowery; Fiscal Year: 2003
    ..The applicant will explore the effects of physiotones on postoperative pain in adolescents after spinal fusion. The specific aims of this proposal are to: 1) assess the effects of physiotones on post-operative pain ..
  38. Modification of Intervertebral Disk Fatigue Resistance
    Thomas Hedman; Fiscal Year: 2001
    ..Current treatments for spinal instability and low-back pain, including spinal fusion, are generally ineffective in slowing the progression of degeneration...
  39. Bone Regeneration Scaffolds
    Ronald Hill; Fiscal Year: 2005
    In 2001, a spinal fusion procedure was performed on average every 2 minutes in the United States at a mean cost of $34,000...
  40. GENETIC ANALYSIS OF FAMILIAL IDIOPATHIC SCOLIOSIS
    Nancy Miller; Fiscal Year: 2006
    ..When progressive, marked deformity and operative spinal fusion can result...
  41. Biopolymeric Strength Augmenation to the Spine
    David Hile; Fiscal Year: 2004
    b>Spinal fusion is the most common type of bone grafting procedure. Despite the continuing evolution of devices designed to aid in interbody fusion, nonunion remains problematic...
  42. CALCIUM PHOSPHATE BONE REPAIR MATERIALS
    Laurence Chow; Fiscal Year: 2009
    ..these properties should be useful for applications such as periodontal defect repair, ridge augmentation, and spinal fusion. Aim 3...
  43. HARVESTING AUTOLOGOUS GROWTH FACTORS FOR SURGICAL USE
    Don Olsen; Fiscal Year: 2002
    ..diabetic and venous ulcers, while autologous growth factors are used in major orthopedic applications such as spinal fusion and joint implants...
  44. Discovery of Peptide-based Bone Morphogenic Protein Mimetics
    Paul Hamilton; Fiscal Year: 2005
    ..Two recombinant human BMPs, rhBMP-2 and rhBMP-7, are currently used in clinical applications to promote spinal fusion and fracture-healing...
  45. Directed Differentiation of Human Mesenchymal Stem Cells for Bone Repair
    JAN STEGEMANN; Fiscal Year: 2009
    ..benefit from therapies that accelerate bone healing in a difficult environment, such as avascular necrosis, spinal fusion and implant fixation...
  46. INTEGRATING DESIGN AND MANUFACTURE OF COMPOSITE IMPLANTS
    Mark Freas; Fiscal Year: 2001
    ..In particular, carbon fiber reinforced polymer composites are radiolucent, making them ideal candidates for spinal fusion applications...
  47. Complications of Surgery for Spinal Stenosis: A Clinical Prediction Rule
    Richard A Deyo; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: A new method for estimating surgical risk will improve patient safety and assist in surgical decision-making, informed consent, monitoring surgical products, &improving quality assessment. ..
  48. Development of a Spinal Intervertebral Disc Prosthesis
    GLENN BUTTERMANN; Fiscal Year: 2003
    Chronic back pain is a common disability in which spinal fusion surgery is sometimes beneficial...
  49. Tissue Engineering Utilizing BMP Gene Therapy
    GREGORY HELM; Fiscal Year: 2004
    ....
  50. Effect of vertebral endplate composition on disc health
    Frank Acosta; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  51. NIAMS Muiltidisciplinary Clinical Research Center in...
    Richard Deyo; Fiscal Year: 2006
    ..It will require computer modeling, based on precedents in MR-PET scanning. We will determine if surgeons will accept the synthesized images as a replacement for CT-myelography for purposes of surgical planning. ..
  52. UW Multidisciplinary Clinical Research Training (RMI)
    Richard Deyo; Fiscal Year: 2004
    ....
  53. PREVENTING CO-MORBID MENTAL & PHYSICAL HEALTH DISABILITY
    Robert Gatchel; Fiscal Year: 2007
    ..These results will have implications for potentially significant healthcare cost savings for this highly prevalent co-morbid disability problem. [unreadable] [unreadable]..
  54. Evaluating Reversible Spinal Fixation in Biped Rats
    Charles Henderson; Fiscal Year: 2003
    ..This progressive plan of study will permit evaluation of biological mechanisms thought to link the manipulable lesion (subluxation) with spinal manipulation and the chiropractic clinical experience. ..
  55. CERVICAL SPINE INJURIES IN FRONT, REAR AND SIDE IMPACTS
    Manohar Panjabi; Fiscal Year: 2004
    ....
  56. AN EVALUATION AND TREATMENT STUDY OF TMD
    Robert Gatchel; Fiscal Year: 2004
    ..The better understanding of such a mechanism can potentially yield even more effective assessment and treatment approaches for chronic pain syndromes such as TMD. ..
  57. Incidence & Outcomes of SSI After Breast Cancer Surgery
    Margaret Olsen; Fiscal Year: 2008
    ....
  58. EARLY DETECTION AND PREVENTION OF CHRONIC PAIN DISABILIT
    Robert Gatchel; Fiscal Year: 2003
    ..These 3 research projects will explore the efficacy of early identification of "high risk" acute patients in order to provide biobehavioral treatment intervention, while simultaneously evaluating cost-effectiveness. ..
  59. P I/II Intraventricular DepoCyt (OD # 06-2348) in Glioblastoma (76,730, 11/06)
    BRUCE MICHAEL FRANKEL; Fiscal Year: 2010
    ..This has also been the basis for successful application and granting of Orphan-Drug designation for cytarabine (Ara-C) liposome injection (trade name: DepoCyt) for the treatment of gliomas. ..
  60. 2006 Summer Bioengineering Conference
    Vijay Goel; Fiscal Year: 2006
    ..This should help create the necessary work force of varied interests in the health care field. [unreadable] [unreadable] [unreadable]..
  61. Prevention of Healthcare-Associated Drug-Resistant GNR
    Lisa Maragakis; Fiscal Year: 2006
    ..Maragakis with the skills she needs to develop into an independent clinical investigator in epidemiologic research for the prevention of healthcare-associated infections. ..
  62. Catheter Dwell Time and Risk of Bloodstream Infections in Hospitalized Neonates
    Aaron M Milstone; Fiscal Year: 2011
    ..This project will help to develop evidence-based strategies to prevent bloodstream infections among vulnerable infants hospitalized in the neonatal intensive care unit. ..