amputation

Summary

Summary: The removal of a limb or other appendage or outgrowth of the body. (Dorland, 28th ed)

Top Publications

  1. ncbi Diabetes- and nondiabetes-related lower extremity amputation incidence before and after the introduction of better organized diabetes foot care: continuous longitudinal monitoring using a standard method
    Ronan J Canavan
    Diabetes Care Centre, James Cook University Hospital, Middlesborough, UK
    Diabetes Care 31:459-63. 2008
  2. pmc Amputation-induced reactive oxygen species are required for successful Xenopus tadpole tail regeneration
    Nick R Love
    Faculty of Life Sciences, University of Manchester, UK
    Nat Cell Biol 15:222-8. 2013
  3. ncbi Predictors of cure, amputation and follow-up dropout among patients with mycetoma seen at the Mycetoma Research Centre, University of Khartoum, Sudan
    Hagir A M Zein
    Mycetoma Research Centre, University of Khartoum, Khartoum, Sudan
    Trans R Soc Trop Med Hyg 106:639-44. 2012
  4. ncbi The global burden of diabetic foot disease
    Andrew J M Boulton
    Department of Medicine, University of Manchester, Manchester, UK
    Lancet 366:1719-24. 2005
  5. pmc Expression of secreted Wnt pathway components reveals unexpected complexity of the planarian amputation response
    Kyle A Gurley
    Department of Neurobiology and Anatomy, Howard Hughes Medical Institute, University of Utah School of Medicine, 401 MREB, 20N 1900E, Salt Lake City, UT 84132, USA
    Dev Biol 347:24-39. 2010
  6. ncbi Negative pressure wound therapy after partial diabetic foot amputation: a multicentre, randomised controlled trial
    David G Armstrong
    Scholl s Center for Lower Extremity Ambulatory Research CLEAR, Rosalind Franklin University of Medicine and Science, Chicago, IL 60064, USA
    Lancet 366:1704-10. 2005
  7. ncbi Decrease of thalamic gray matter following limb amputation
    B Draganski
    Department of Neurology, University of Regensburg, Germany
    Neuroimage 31:951-7. 2006
  8. ncbi Effect of fibroblast growth factor NV1FGF on amputation and death: a randomised placebo-controlled trial of gene therapy in critical limb ischaemia
    Jill Belch
    The Institute of Cardiovascular Research, Vascular and Inflammatory Diseases Research Unit, Ninewells Hospital and Medical School, Dundee, UK
    Lancet 377:1929-37. 2011
  9. ncbi Plasticity of metabotropic glutamate receptor-dependent long-term depression in the anterior cingulate cortex after amputation
    SukJae Joshua Kang
    Department of Brain and Cognitive Sciences, College of Natural Sciences, Seoul National University, Seoul 151 746, Korea
    J Neurosci 32:11318-29. 2012
  10. ncbi Review of secondary physical conditions associated with lower-limb amputation and long-term prosthesis use
    Robert Gailey
    Department of Physical Therapy, University of Miami Leonard M Miller School of Medicine, Coral Gables, FL, USA
    J Rehabil Res Dev 45:15-29. 2008

Detail Information

Publications340 found, 100 shown here

  1. ncbi Diabetes- and nondiabetes-related lower extremity amputation incidence before and after the introduction of better organized diabetes foot care: continuous longitudinal monitoring using a standard method
    Ronan J Canavan
    Diabetes Care Centre, James Cook University Hospital, Middlesborough, UK
    Diabetes Care 31:459-63. 2008
    There is a lack of continuous longitudinal population-based data on lower extremity amputation (LEA) in the U.K...
  2. pmc Amputation-induced reactive oxygen species are required for successful Xenopus tadpole tail regeneration
    Nick R Love
    Faculty of Life Sciences, University of Manchester, UK
    Nat Cell Biol 15:222-8. 2013
    ..the species Xenopus laevis and Xenopus tropicalis have remarkable abilities to regenerate their tails following amputation, through the coordinated activity of numerous growth factor signalling pathways, including the Wnt, Fgf, Bmp, ..
  3. ncbi Predictors of cure, amputation and follow-up dropout among patients with mycetoma seen at the Mycetoma Research Centre, University of Khartoum, Sudan
    Hagir A M Zein
    Mycetoma Research Centre, University of Khartoum, Khartoum, Sudan
    Trans R Soc Trop Med Hyg 106:639-44. 2012
    ..The study objective was to determine the predictors of cure, amputation and follow-up dropout among the studied individuals with mycetoma...
  4. ncbi The global burden of diabetic foot disease
    Andrew J M Boulton
    Department of Medicine, University of Manchester, Manchester, UK
    Lancet 366:1719-24. 2005
    ..An integrated care approach with regular screening and education of patients at risk requires low expenditure and has the potential to reduce the cost of health care...
  5. pmc Expression of secreted Wnt pathway components reveals unexpected complexity of the planarian amputation response
    Kyle A Gurley
    Department of Neurobiology and Anatomy, Howard Hughes Medical Institute, University of Utah School of Medicine, 401 MREB, 20N 1900E, Salt Lake City, UT 84132, USA
    Dev Biol 347:24-39. 2010
    ..We show that after amputation, a wounding response precedes rapid re-organization of the A/P axis...
  6. ncbi Negative pressure wound therapy after partial diabetic foot amputation: a multicentre, randomised controlled trial
    David G Armstrong
    Scholl s Center for Lower Extremity Ambulatory Research CLEAR, Rosalind Franklin University of Medicine and Science, Chicago, IL 60064, USA
    Lancet 366:1704-10. 2005
    Diabetic foot wounds, particularly those secondary to amputation, are very complex and difficult to treat...
  7. ncbi Decrease of thalamic gray matter following limb amputation
    B Draganski
    Department of Neurology, University of Regensburg, Germany
    Neuroimage 31:951-7. 2006
    ..However, little is known about possible structural alterations following amputation and chronic loss of afferent input in humans...
  8. ncbi Effect of fibroblast growth factor NV1FGF on amputation and death: a randomised placebo-controlled trial of gene therapy in critical limb ischaemia
    Jill Belch
    The Institute of Cardiovascular Research, Vascular and Inflammatory Diseases Research Unit, Ninewells Hospital and Medical School, Dundee, UK
    Lancet 377:1929-37. 2011
    Patients with critical limb ischaemia have a high rate of amputation and mortality. We tested the hypothesis that non-viral 1 fibroblast growth factor (NV1FGF) would improve amputation-free survival.
  9. ncbi Plasticity of metabotropic glutamate receptor-dependent long-term depression in the anterior cingulate cortex after amputation
    SukJae Joshua Kang
    Department of Brain and Cognitive Sciences, College of Natural Sciences, Seoul National University, Seoul 151 746, Korea
    J Neurosci 32:11318-29. 2012
    ..Peripheral amputation of the distal tail impaired ACC LTD, an effect that persisted for at least 2 weeks...
  10. ncbi Review of secondary physical conditions associated with lower-limb amputation and long-term prosthesis use
    Robert Gailey
    Department of Physical Therapy, University of Miami Leonard M Miller School of Medicine, Coral Gables, FL, USA
    J Rehabil Res Dev 45:15-29. 2008
    ..physical conditions or complications that may affect the mobility and quality of life of people with lower-limb amputation. Using one or more prostheses causes people with amputation to alter the biomechanics of their movement...
  11. ncbi Plasma total bilirubin levels predict amputation events in type 2 diabetes mellitus: the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) study
    K H Chan
    Department of Cardiology, Royal Prince Alfred Hospital, Sydney, NSW, Australia
    Diabetologia 56:724-36. 2013
    ..However, the relationship between bilirubin and lower-limb amputation, a consequence of PAD, is currently unknown...
  12. ncbi Molecular pathways needed for regeneration of spinal cord and muscle in a vertebrate
    Caroline W Beck
    Centre for Regenerative Medicine, Department of Biology and Biochemistry, University of Bath, BA2 7AY, Bath, United Kingdom
    Dev Cell 5:429-39. 2003
    The tail of the frog tadpole, comprising spinal cord, muscle, and notochord, regenerates following partial amputation. We show that, in Xenopus, this occurs throughout development, except for a "refractory period" between stages ..
  13. ncbi Incidence of phantom phenomena including phantom limb pain 6 months after major lower limb amputation in patients with peripheral vascular disease
    Cliff Richardson
    Liverpool John Moores University, Liverpool, UK
    Clin J Pain 22:353-8. 2006
    Contentions exist regarding the true incidence of phantom limb pain (PLP) and other associated post-amputation phenomena. Recognizing and understanding these phenomena would assist in the rehabilitation of amputees...
  14. ncbi Requirement for Wnt and FGF signaling in Xenopus tadpole tail regeneration
    Gufa Lin
    Centre for Regenerative Medicine, Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, UK
    Dev Biol 316:323-35. 2008
    ..The results show that the molecular mechanism of Xenopus tadpole tail regeneration is surprisingly similar to that of the Xenopus limb bud and the zebrafish caudal fin, despite the difference of anatomy...
  15. ncbi Psychosocial adjustment to lower-limb amputation: a review
    Olga Horgan
    Dublin Psychoprosthetics Group, Department of Psychology, Trinity College, University of Dublin, Dublin, Ireland
    Disabil Rehabil 26:837-50. 2004
    To review the existing literature on the social and psychological challenges faced by people with an amputation and to provide a detailed analysis of the literature examining psychological adjustment to these challenges across time.
  16. ncbi Reduction in diabetic amputations over 11 years in a defined U.K. population: benefits of multidisciplinary team work and continuous prospective audit
    Singhan Krishnan
    Ipswich Hospital, Diabetes Center, Heath Road, Ipswich, Suffolk IP4 5PD, UK
    Diabetes Care 31:99-101. 2008
    To assess changes in diabetic lower-extremity amputation rates in a defined relatively static population over an 11-year period following the introduction of a multidisciplinary foot team.
  17. ncbi Trends in lower extremity amputations in people with and without diabetes in England, 1996-2005
    Eszter Panna Vamos
    Department of Primary Care and Public Health, Imperial College London, UK
    Diabetes Res Clin Pract 87:275-82. 2010
    ..To examine trends in non-traumatic lower extremity amputations over a 10-year-period in people with and without diabetes (DM) in England...
  18. pmc Late complications and survival of endoprosthetic reconstruction after resection of bone tumors
    Ahmad Shehadeh
    Washington Cancer Institute at Washington Hospital Center, Washington, DC, USA
    Clin Orthop Relat Res 468:2885-95. 2010
    ..While complications following massive endoprosthetic reconstruction have been previously described, the incidence and effects of these complications over extended periods of time have not been well characterized in large series...
  19. pmc Effect of fenofibrate on amputation events in people with type 2 diabetes mellitus (FIELD study): a prespecified analysis of a randomised controlled trial
    Kushwin Rajamani
    National Health and Medical Research Council Clinical Trials Centre, University of Sydney, Sydney, NSW, Australia
    Lancet 373:1780-8. 2009
    ..Our aim was to assess the effect of fenofibrate on amputation events in a large cohort of patients with type 2 diabetes.
  20. ncbi The effect of tactile and visual sensory inputs on phantom limb awareness
    Judith P Hunter
    Toronto Western Research Institute, Toronto Western Hospital, University Health Network, Ontario, Canada
    Brain 126:579-89. 2003
    Multiple sensory stimuli contribute to the conscious awareness of the body. It is well known that limb amputation can result in abnormal body awareness, but the manner in which the CNS constructs and updates a body schema after injury is ..
  21. ncbi The impact of tail tip amputation and ink tattoo on C57BL/6JBomTac mice
    Dorte Bratbo Sørensen
    Centre for Bioethics and Risk Assessment, Division of Laboratory Animal Science, Department of Veterinary Pathobiology, Royal Veterinary and Agricultural University, Groennegaardsvej 15, DK 1870 Frederiksberg C, Denmark
    Lab Anim 41:19-29. 2007
    ..Seven weeks after tail amputation, the animals were euthanized. The remaining part of the tail was evaluated histopathologically...
  22. pmc A strategy for identifying locomotion modes using surface electromyography
    He Huang
    Department of Electrical, Computer, and Biomedical Engineering, University of Rhode Island, Kingston, RI 02881, USA
    IEEE Trans Biomed Eng 56:65-73. 2009
    ..1%, and 5.2% +/- 3.7%, respectively. Comparable results were also observed in our pilot study on the subjects with TF amputations. The outcome of this investigation could promote the future design of neural-controlled artificial legs...
  23. ncbi Autologous bone-marrow mononuclear cell implantation reduces long-term major amputation risk in patients with critical limb ischemia: a comparison of atherosclerotic peripheral arterial disease and Buerger disease
    Naomi Idei
    Department of Cardiovascular Medicine, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    Circ Cardiovasc Interv 4:15-25. 2011
    ..The purpose of this study was to evaluate long-term clinical outcomes after autologous BM-MNC implantation in patients with CLI...
  24. pmc The incidence and health economic burden of ischemic amputation in Minnesota, 2005-2008
    James M Peacock
    Center for Health Promotion, Health Promotion and Chronic Disease Division, Minnesota Department of Health, PO Box 64882, St Paul, MN 55164 0882, USA
    Prev Chronic Dis 8:A141. 2011
    ..of peripheral artery disease (PAD), is associated with high rates of myocardial infarction, stroke, and amputation, and has a high health economic cost...
  25. pmc Long-term prognosis of diabetic foot patients and their limbs: amputation and death over the course of a decade
    Stephan Morbach
    Department of Diabetes and Angiology, Marienkrankenhaus, SOEST, Germany
    Diabetes Care 35:2021-7. 2012
    ..The purpose of our study was therefore to prospectively investigate the limb and person survival of DFU patients during a follow-up period of more than 10 years...
  26. ncbi A comparison of two diabetic foot ulcer classification systems: the Wagner and the University of Texas wound classification systems
    S O Oyibo
    Department of Medicine and Diabetes, Manchester Royal Infirmary, UK
    Diabetes Care 24:84-8. 2001
    ..In this study the following two ulcer classification systems were applied to new foot ulcers to compare them as predictors of outcome: the Wagner (grade) and the University of Texas (LT) (grade and stage) wound classification systems...
  27. ncbi Risk factors for 30-day postoperative complications and mortality after below-knee amputation: a study of 2,911 patients from the national surgical quality improvement program
    Philip J Belmont
    Department of Orthopaedic Surgery, William Beaumont Army Medical Center, Texas Tech University Health Sciences Center, El Paso, TX 79920, USA
    J Am Coll Surg 213:370-8. 2011
    ..This investigation sought to evaluate risk factors for morbidity and mortality from a large series of below-knee amputees prospectively entered in a national database...
  28. ncbi Questionnaire for Persons with a Transfemoral Amputation (Q-TFA): initial validity and reliability of a new outcome measure
    Kerstin Hagberg
    Department of Prosthetics and Orthotics, Bruna Stråket 11b, plan 5, Sahlgrenska University Hospital, S 413 45 Goteborg, Sweden
    J Rehabil Res Dev 41:695-706. 2004
    The Questionnaire for Persons with a Transfemoral Amputation (Q-TFA) is a new self-report measure developed for nonelderly transfemoral amputees using a socket- or osseointegrated prosthesis to reflect use, mobility, problems, and global ..
  29. ncbi The adverse effects of race, insurance status, and low income on the rate of amputation in patients presenting with lower extremity ischemia
    Mohammad H Eslami
    Division of Vascular Surgery, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Vasc Surg 45:55-9. 2007
    ..This study was undertaken to determine the correlation of low socioeconomic status and race on the severity of ischemic presentation and the subsequent amputation rate.
  30. ncbi Nomogram predictive of cancer specific survival in patients undergoing partial or total amputation for squamous cell carcinoma of the penis
    Michael W Kattan
    Department of Biostatistics and Epidemiology, The Cleveland Clinic Foundation, Cleveland, Ohio, USA
    J Urol 175:2103-8; discussion 2108. 2006
    ..We created the first nomograms to predict cancer specific survival probabilities of patients with squamous cell carcinoma of the penis, clustering prognostic information from the most commonly used clinical and pathological variables...
  31. ncbi Diabetes is the strongest risk factor for lower-extremity amputation in new hemodialysis patients
    Rebecca A Speckman
    Rollins School of Public Health, Emory University, Atlanta, Georgia, USA
    Diabetes Care 27:2198-203. 2004
    ..disease (ESRD) patients, especially those with diabetes, have an increased risk of nontraumatic lower-extremity amputation (LEA)...
  32. ncbi Age and sex may significantly interact with diabetes on the risks of lower-extremity amputation and peripheral revascularization procedures: evidence from a cohort of a half-million diabetic patients
    Hua Fen Chen
    Department of Public Health, College of Medicine, Fu Jen Catholic University, 510 Chung Cheng Rd, Hsinchuang, Taipei Hsien, 242 Taiwan
    Diabetes Care 29:2409-14. 2006
    ..data, we prospectively investigated the age- and sex-specific incidence density and relative hazards of nontraumatic lower-extremity amputation (LEA) and peripheral revascularization procedure (PRP) of the diabetic population in Taiwan.
  33. ncbi Nonmetastatic osteosarcoma of the extremity with pathologic fracture at presentation: local and systemic control by amputation or limb salvage after preoperative chemotherapy
    Gaetano Bacci
    Department of Musculoskeletal Oncology of the Rizzoli Orthopaedic Institute, Bologna, Italy
    Acta Orthop Scand 74:449-54. 2003
    ..Surgery consisted of limb salvage (34 patients), amputation (11 patients) and rotationplasty (1 patient). The average follow-up was 11 (3-20) years...
  34. ncbi Surgical outcomes in osteosarcoma
    R J Grimer
    Oncology Service, Royal Orthopaedic Hospital, Northfield, Birmingham, UK
    J Bone Joint Surg Br 84:395-400. 2002
    ..limb-salvage surgery and who developed local recurrence still had a better survival than those who had primary amputation (37% v 31% survival at five years)...
  35. pmc Trends in lower-extremity amputations in people with and without diabetes in Spain, 2001-2008
    Ana López-de-Andrés
    Preventive Medicine and Public Health Teaching and Research Unit, Health Sciences Faculty, Rey Juan Carlos University, Madrid, Spain
    Diabetes Care 34:1570-6. 2011
    ..To examine trends in nontraumatic lower-extremity amputations (LEAs) over an 8-year period in patients with and without diabetes in Spain...
  36. ncbi Clinical and functional outcomes of patients with a pathologic fracture in high-grade osteosarcoma
    Peter C Ferguson
    Division of Orthopaedic Surgery, Mount Sinai Hospital, Department of Surgery, University Musculoskeletal Oncology Unit, University of Toronto, Toronto, Ontario, Canada
    J Surg Oncol 102:120-4. 2010
    ..There have been variable reports of outcomes of patients with osteosarcoma and pathologic fractures. The purpose of this study was to document outcomes after management of this clinical entity at a single large oncology center...
  37. pmc Hyperbaric oxygen therapy facilitates healing of chronic foot ulcers in patients with diabetes
    Magnus Löndahl
    Institution for Clinical Sciences in Lund, Lund University, Lund, Sweden
    Diabetes Care 33:998-1003. 2010
    ..Chronic diabetic foot ulcers are a source of major concern for both patients and health care systems. The aim of this study was to evaluate the effect of hyperbaric oxygen therapy (HBOT) in the management of chronic diabetic foot ulcers...
  38. ncbi Prognostic factors and outcomes for osteosarcoma: an international collaboration
    Emilios E Pakos
    Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina 45110, Greece
    Eur J Cancer 45:2367-75. 2009
    ..of metastatic disease at diagnosis, development of local recurrence when the patient was first seen, use of amputation instead of limb salvage/wide resection, employment of unusual treatments, use of chemotherapeutic regimens other ..
  39. ncbi Multifactorial intervention and cardiovascular disease in patients with type 2 diabetes
    Peter Gaede
    Steno Diabetes Center, Copenhagen, Denmark
    N Engl J Med 348:383-93. 2003
    ....
  40. ncbi H+ pump-dependent changes in membrane voltage are an early mechanism necessary and sufficient to induce Xenopus tail regeneration
    Dany S Adams
    Center for Regenerative and Developmental Biology, Forsyth Institute, and Developmental Biology Department, Harvard School of Dental Medicine, 140 The Fenway, Boston, MA 02115, USA
    Development 134:1323-35. 2007
    ..The V-ATPase is specifically upregulated in existing wound cells by 6 hours post-amputation. Pharmacological or molecular genetic loss of V-ATPase function and the consequent strong depolarization ..
  41. ncbi National trends in lower extremity bypass surgery, endovascular interventions, and major amputations
    Philip P Goodney
    Dartmouth Hitchcock Medical Center, Lebanon, NH 03765, USA
    J Vasc Surg 50:54-60. 2009
    ..Whether endovascular interventions substitute for conventional bypass surgery or are simply additive has not been investigated, and their effect on amputation rates is unknown.
  42. ncbi Proximodistal patterning during limb regeneration
    Karen Echeverri
    Max Planck Institute for Molecular Cell Biology and Genetics, Pfotenhauerstra, 108 01307 Dresden, Germany
    Dev Biol 279:391-401. 2005
    ..During this process, only the missing portion of the limb is precisely replaced--amputation in the upper arm results in regeneration of the entire limb, while amputation at the wrist produces a hand...
  43. ncbi Effects of ethnicity and nephropathy on lower-extremity amputation risk among diabetic veterans
    Bessie A Young
    Epidemiologic Research and Information Center, Department of Veterans Affairs, Seattle Veterans Affairs Puget Sound Health Care System, Seattle, Washington 98108, USA
    Diabetes Care 26:495-501. 2003
    To describe ethnic differences in the risk of amputation in diabetic patients with diabetic nephropathy.
  44. ncbi Amputation as a marker of the quality of foot care in diabetes
    W J Jeffcoate
    Foot Ulcer Trials Unit, Department of Diabetes and Endocrinology, City Hospital, Nottingham, NG5 1PB, UK
    Diabetologia 47:2051-8. 2004
    Strategic targets for the management of foot ulcers focus on reducing the incidence of amputation. While data on the incidence of amputation can be obtained relatively easily, the figures require very careful interpretation...
  45. ncbi Coping after trans-femoral amputation due to trauma or tumour--a phenomenological approach
    C Sjödahl
    Department of Physical Therapy, Lund University, Sweden
    Disabil Rehabil 26:851-61. 2004
    To describe, by use of a phenomenological approach, how relatively young trans-femoral amputees experienced their amputation and their coping strategies in the acute phase and over time.
  46. ncbi Physical capacity and walking ability after lower limb amputation: a systematic review
    J M van Velzen
    Heliomare Research and Development, Wijk aan Zee, Amsterdam, The Netherlands
    Clin Rehabil 20:999-1016. 2006
    To review the influence of physical capacity on regaining walking ability and the development of walking ability after lower limb amputation.
  47. pmc Can major amputation rates be decreased in diabetic foot ulcers with hyperbaric oxygen therapy?
    Ahmet Kaya
    Department of Orthopaedics and Traumatology, Tepecik Training and Research Hospital, Izmir, Turkey
    Int Orthop 33:441-6. 2009
    ..The aim of this study is to evaluate whether hyperbaric oxygen can decrease major amputation rates and to determine the predictive factors...
  48. ncbi Surgical implications of early failed endovascular intervention of the superficial femoral artery
    Charles S Joels
    Academic Department of Surgery, Greenville Hospital System University Medical Center, Greenville, SC 29605, USA
    J Vasc Surg 47:562-5. 2008
    ..The purpose of this study was to determine whether early failure after superficial femoral artery intervention influences subsequent revascularization options...
  49. ncbi Intralesional injections of Citoprot-P (recombinant human epidermal growth factor) in advanced diabetic foot ulcers with risk of amputation
    José I Fernández-Montequín
    Service of Diabetic Microangiopathy, National Institute for Angiology and Vascular Surgery, Havana, Cuba
    Int Wound J 4:333-43. 2007
    ..test two rhEGF dose levels in type 1 or 2 diabetes patients with Wagner's grade 3 or 4 ulcers, with high risk of amputation. Subjects were randomised to receive 75 (group I) or 25 mug (group II) rhEGF through intralesional injections, ..
  50. ncbi Health related quality of life, cognitive function, and depression in diabetic patients with foot ulcer or amputation. A preliminary study
    Amanda Willrich
    Loyola University Medical Center, Orthopaedic Surgery and Rehabilitation, Maywood, IL 60153, USA
    Foot Ankle Int 26:128-34. 2005
    Diabetic foot ulcers, foot infection, Charcot foot arthropathy, and lower extremity amputation have a severe negative effect on the health-related quality of life in individuals with diabetes...
  51. ncbi When is a technically successful peripheral angioplasty effective in preventing above-the-ankle amputation in diabetic patients with critical limb ischaemia?
    E Faglia
    Diabetology Centre Diabetic Foot Centre IRCCS Multimedica, Sesto San Giovanni, Milan, Italy
    Diabet Med 24:823-9. 2007
    To determine parameters predictive of avoidance of major (above-the-ankle) amputation after a technically successful peripheral angioplasty (PTA) in patients with diabetes with critical limb ischaemia.
  52. ncbi Nerve-induced ectopic limb blastemas in the Axolotl are equivalent to amputation-induced blastemas
    Akira Satoh
    Department of Developmental and Cell Biology, Natural Sciences II Division, 4114 Natural Sciences II, University of California Irvine, Irvine, CA 92697 2305, USA
    Dev Biol 312:231-44. 2007
    ..cell contribution, cell migration and nerve dependency indicating that an ectopic blastema is equivalent to an amputation-induced blastema...
  53. ncbi Depression and anxiety symptoms after lower limb amputation: the rise and fall
    Rajiv Singh
    Department of Neurorehabilitation, Northern General Hospital, Sheffield, UK
    Clin Rehabil 23:281-6. 2009
    To examine the time course of anxiety and depressive symptoms over a three year period after amputation.
  54. pmc Amputation induces stem cell mobilization to sites of injury during planarian regeneration
    Otto C Guedelhoefer
    Department of Neurobiology and Anatomy, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
    Development 139:3510-20. 2012
    ..Here, we show that planarian stem cells directionally migrate to amputation sites during regeneration. We also show that during tissue homeostasis they are stationary...
  55. ncbi Predictive value of routine transcutaneous tissue oxygen tension (tcpO2) measurement for the risk of non-healing and amputation in diabetic foot ulcer patients with non-palpable pedal pulses
    Ruth Ladurner
    Department of General and Transplant Surgery, University Hospital of Tubingen, Germany
    Med Sci Monit 16:CR273-7. 2010
    ..It was evaluated whether transcutaneous tissue oxygen tension (tcpO2) measurement, when assessed in daily routine, can be used to predict the risk of non-healing and amputation in diabetic foot ulcer patients with non-palpable pedal pulses.
  56. ncbi A meta-analysis of amputation versus limb salvage in mangled lower limb injuries--the patient perspective
    Maheswara Akula
    Department of Trauma and Orthopaedics, Leeds General Infirmary, Great George Street, Leeds LS1 3EX, United Kingdom
    Injury 42:1194-7. 2011
    ..demonstrated that lower limb reconstruction is more acceptable psychologically to patients with severe lower limb trauma compared with amputation, even though the physical outcome for both management pathways was more or less the same.
  57. ncbi Feedforward control strategies of subjects with transradial amputation in planar reaching
    Anthony J Metzger
    Center for Applied Biomechanics and Rehabilitation Research, National Rehabilitation Hospital, Washington, DC, USA
    J Rehabil Res Dev 47:201-11. 2010
    ..People with upper-limb amputation do not fully incorporate prosthetic devices into their activities of daily living...
  58. pmc Changes in the incidence of lower extremity amputations in individuals with and without diabetes in England between 2004 and 2008
    Eszter P Vamos
    Department of Primary Care and Public Health, Imperial College London, London, UK
    Diabetes Care 33:2592-7. 2010
    ..To describe recent trends in the incidence of nontraumatic amputations among individuals with and without diabetes and estimate the relative risk of amputations among individuals with diabetes in England...
  59. pmc Wound healing and blastema formation in regenerating digit tips of adult mice
    Warnakulasuriya Akash Fernando
    Division of Developmental Biology, Department of Cell and Molecular Biology, Tulane University, New Orleans, LA 70118, USA
    Dev Biol 350:301-10. 2011
    b>Amputation of the distal region of the terminal phalanx of mice causes an initial wound healing response followed by blastema formation and the regeneration of the digit tip...
  60. ncbi Differences in minor amputation rate in diabetic foot disease throughout Europe are in part explained by differences in disease severity at presentation
    P van Battum
    Division of Endocrinology, Department of Medicine, Maastricht University Medical Centre, P Debyelaan 25, Maastricht, The Netherlands
    Diabet Med 28:199-205. 2011
    The incidence of minor amputation may vary significantly, and determinants of minor amputation have not been studied systematically...
  61. ncbi Trends in the national outcomes and costs for claudication and limb threatening ischemia: angioplasty vs bypass graft
    Teviah Sachs
    Department of Vascular Surgery, Beth Israel Deaconess Medical Center, Harvard, MA 02215, USA
    J Vasc Surg 54:1021-1031.e1. 2011
    ..The associated costs are poorly defined in the literature. We sought to determine national estimates for the costs, utilization, and outcomes of angioplasty and bypass graft for the treatment of both claudication and limb threat...
  62. ncbi Risk factors for lower extremity amputation among patients with diabetes in Singapore
    Yong Yang
    Department of Epidemiology, Singapore General Hospital, Singapore 169608
    J Diabetes Complications 25:382-6. 2011
    Among other risk factors, renal disease and ethnicity have been associated with diabetic lower extremity amputation (LEA) in Western populations. However, little is known about risk factors for LEA among Asian patients.
  63. ncbi Effect of zoledronic acid and amputation on bone invasion and lung metastasis of canine osteosarcoma in nude mice
    Tobie D Wolfe
    Department of Veterinary Biosciences, The Ohio State University, Columbus, 43210, USA
    Clin Exp Metastasis 28:377-89. 2011
    ..Current treatment options include amputation of the afflicted limb, limb-sparing procedures, or palliative radiation with or without adjunct chemotherapy...
  64. pmc Trends in the incidence of lower extremity amputations in people with and without diabetes over a five-year period in the Republic of Ireland
    Claire M Buckley
    Department of General Practice, University College Cork, Cork, Ireland
    PLoS ONE 7:e41492. 2012
    ..non-traumatic amputations among people with and without diabetes and estimate the relative risk of an individual with diabetes undergoing a lower extremity amputation compared to an individual without diabetes in the Republic of Ireland.
  65. ncbi Bypass versus Angioplasty in Severe Ischaemia of the Leg (BASIL) trial: Analysis of amputation free and overall survival by treatment received
    Andrew W Bradbury
    Department of Vascular Surgery, University of Birmingham, Heart of England NHS Foundation Trust, Solihull Hospital, Lode Lane, Birmingham, UK
    J Vasc Surg 51:18S-31S. 2010
    ..a bypass surgery (BSX)-first strategy was associated with improvements in subsequent overall survival (OS) and amputation-free survival (AFS) of about 7 and 6 months, respectively...
  66. ncbi Association between glycated haemoglobin and the risk of lower extremity amputation in patients with diabetes mellitus-review and meta-analysis
    A I Adler
    Wolfson Diabetes and Endocrine Clinic, Institute of Metabolic Sciences, Addenbrooke s Hospital, Cambridge University Foundation Hospital Trust, Box 281, Hills Road, Cambridge CB2 2QQ, UK
    Diabetologia 53:840-9. 2010
    Diabetes increases the risk of lower extremity amputation (LEA)...
  67. ncbi The influence of falling, fear of falling, and balance confidence on prosthetic mobility and social activity among individuals with a lower extremity amputation
    W C Miller
    Faculty of Medicine, School of Rehabilitation Sciences, University of British Columbia, Vancouver, BC, Canada
    Arch Phys Med Rehabil 82:1238-44. 2001
    ..To assess in amputee patients the relationship between having fallen in the past 12 months, fear of falling, and balance confidence on mobility capability, mobility performance, and social activity...
  68. ncbi Preliminary assessment of balance with the Berg Balance Scale in adults who have a leg amputation and dwell in the community: Rasch rating scale analysis
    Christopher Kevin Wong
    C K Wong, PT, PhD, OCS, Program in Physical Therapy, Columbia University, 710 W 168th St, New York, NY 10032 USA, and Department of Rehabilitation and Regenerative Medicine, Columbia University Medical Center, New York, New York
    Phys Ther 93:1520-9. 2013
    Self-report measures of balance and multidimensional mobility assessments are common for people with a leg amputation, yet clinical assessment of balance ability remains less explored...
  69. ncbi Analysis of hoxa11 and hoxa13 expression during patternless limb regeneration in Xenopus
    Shiro Ohgo
    Department of Developmental Biology and Neurosciences, Graduate School of Life Sciences, Tohoku University, Aobayama Aoba ku, Sendai 980 8578, Japan
    Dev Biol 338:148-57. 2010
    ..cells that do not produce proper patterning, resulting in a patternless regenerate, a spike, regardless of the amputation level...
  70. ncbi [Body Integrity Identity Disorder (BIID): interrogation of patients and theories for explanation]
    E Kasten
    Institut fur Medizinische Psychologie, Universitat zu Lubeck, Lubeck, Germany
    Fortschr Neurol Psychiatr 77:16-24. 2009
    ..or Body Integrity Identity Disorder (BIID) is the intensive feeling that the body will be "more complete" after amputation of a limb...
  71. ncbi Preliminary evidence for a fronto-parietal dysfunction in able-bodied participants with a desire for limb amputation
    Olaf Blanke
    Laboratory of Cognitive Neuroscience, Brain Mind Institute, Ecole Polytechnique Federale de Lausanne EPFL, Lausanne, Switzerland Department of Neurology, University Hospital, Zurich, Switzerland
    J Neuropsychol 3:181-200. 2009
    Reports of able-bodied participants with the persisting desire for limb amputation raise legal and ethical questions that are partly due to insufficient empirical knowledge about the condition...
  72. ncbi Body integrity identity disorder: from a psychological to a neurological syndrome
    Anna Sedda
    Psychology Department, University of Pavia, Piazza Botta 11, 27100 Pavia, Italy
    Neuropsychol Rev 21:334-6. 2011
    Body Integrity Identity Disorder (BIID) is a condition in which individuals experience an intense desire for amputation of an healthy limb...
  73. ncbi The burden of amputation among hemodialysis patients in the Dialysis Outcomes and Practice Patterns Study (DOPPS)
    Christian Combe
    Service de Nephrologie, Centre Hospitalier Universitaire de Bordeaux, Unité INSERM U889, université Bordeaux 2 Victor Segalen, Bordeaux, France
    Am J Kidney Dis 54:680-92. 2009
    Hemodialysis patients are at increased risk of amputation, particularly those with diabetes. Limited data exist about the prevalence, incidence, risk factors for, and sequelae of amputation in hemodialysis patients.
  74. ncbi Body integrity identity disorder: the persistent desire to acquire a physical disability
    Michael B First
    Department of Psychiatry, New York State Psychiatric Institute, Columbia University, New York, NY 10032, USA
    Psychopathology 45:3-14. 2012
    ..g., amputation, paraplegia) since childhood that to date has not been formally described in the psychiatric nosology...
  75. pmc A retrospective analysis of amputation rates in diabetic patients: can lower extremity amputations be further prevented?
    Alexandra Alvarsson
    Rolf Luft Centre for Diabetes Research, Department of Molecular Medicine and Surgery, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden
    Cardiovasc Diabetol 11:18. 2012
    ..Our aim was to investigate changes in the amputation rate in patients with DM at the Karolinska University Hospital in Solna (KS) following the introduction of ..
  76. ncbi Variation in the recorded incidence of amputation of the lower limb in England
    N Holman
    Diabetes Health Intelligence, Yorkshire and Humber Public Health Observatory, York, UK
    Diabetologia 55:1919-25. 2012
    The study aimed to explore the variation in recorded incidence of lower limb amputation in England.
  77. pmc Trends in initial lower extremity amputation rates among Veterans Health Administration health care System users from 2000 to 2004
    Chin Lin Tseng
    Department of Veterans Affairs New Jersey Healthcare System Center for Healthcare Knowledge Management, East Orange, New Jersey, USA
    Diabetes Care 34:1157-63. 2011
    To evaluate temporal trends in rates of initial lower extremity amputation (ILEA) among patients with diabetes in the Veterans Health Administration (VHA).
  78. ncbi Body integrity identity disorder: deranged body processing, right fronto-parietal dysfunction, and phenomenological experience of body incongruity
    Melita J Giummarra
    Experimental Neuropsychology Research Unit, School of Psychology and Psychiatry, Monash University, Wellington Road, Clayton, VIC 3800, Australia
    Neuropsychol Rev 21:320-33. 2011
    ....
  79. ncbi Factors associated with phantom limb pain: a 31/2-year prospective study
    Joline C Bosmans
    Department of Rehabilitation Medicine and Graduate School for Health Research SHARE, University Medical Centre Groningen, University of Groningen
    Clin Rehabil 24:444-53. 2010
    ..To analyse the prevalence of phantom (limb) pain over time and to analyse factors associated with phantom (limb) pain in a prospective cohort of amputees...
  80. pmc Epimorphic regeneration approach to tissue replacement in adult mammals
    Vineet Agrawal
    Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15219, USA
    Proc Natl Acad Sci U S A 107:3351-5. 2010
    ..site of injury by in vivo administration of chemotactic ECM degradation products in a mammalian model of digit amputation was investigated in the present study...
  81. ncbi Advances in lower-limb prosthetic technology
    Justin Z Laferrier
    Department of Research and Development, Human Engineering Research Laboratories, VA Rehabilitation Research and Development Service, 7108 Highland Dr, Bldg 4, Pittsburgh, PA 15260 1260, USA
    Phys Med Rehabil Clin N Am 21:87-110. 2010
    ..What once seemed impossible is rapidly becoming reality. The future seems limitless, and the replication of anatomic function now seems possible...
  82. ncbi Complex limb salvage or early amputation for severe lower-limb injury: a meta-analysis of observational studies
    Jason W Busse
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
    J Orthop Trauma 21:70-6. 2007
    Leg threatening injuries present patients and clinicians with a difficult decision: whether to pursue primary amputation or limb salvage? The purpose of our study was to review the literature in an effort to inform this management decision...
  83. pmc Proteomic analysis of blastema formation in regenerating axolotl limbs
    Nandini Rao
    Department of Biology and Center for Regenerative Biology and Medicine, Indiana University Purdue University Indianapolis, Indianapolis, IN, USA
    BMC Biol 7:83. 2009
    Following amputation, urodele salamander limbs reprogram somatic cells to form a blastema that self-organizes into the missing limb parts to restore the structure and function of the limb...
  84. ncbi Self-amputation of a healthy hand: a case of body integrity identity disorder
    E D Sorene
    Pulvertaft Hand Centre, Derbyshire Royal Infirmary, Derby, UK
    J Hand Surg Br 31:593-5. 2006
    A case report is presented of self-amputation of a healthy hand. We have reviewed the literature and seek to broaden the scope of understanding of Body Integrity Identity Disorder...
  85. ncbi Xenomelia: a new right parietal lobe syndrome
    Paul D McGeoch
    Center for Brain and Cognition, University of California, San Diego, La Jolla, CA 92093, USA
    J Neurol Neurosurg Psychiatry 82:1314-9. 2011
    ..The authors have recently suggested that an unusual behavioural condition in which otherwise rational individuals desire the amputation of a healthy limb might also arise from right parietal dysfunction.
  86. ncbi Regeneration potency of mouse limbs
    Hideki Masaki
    Department of Developmental Biology and Neurosciences, Graduate School of Life Sciences, Tohoku University, Aoba, Sendai 980 8578, Japan
    Dev Growth Differ 49:89-98. 2007
    ..After the amputation of limbs of a neonatal mouse, hypertrophy of the stump bone was observed at the amputation site, which was ..
  87. ncbi The long-term risks of infection and amputation with limb salvage surgery using endoprostheses
    Lee Jeys
    School House Farm, Purshull Green, Droitwich, Worcestershire WR90NL, UK
    Recent Results Cancer Res 179:75-84. 2009
    ..The main reasons for secondary amputation were locally recurrent disease and deep periprosthetic infection...
  88. pmc Targeted muscle reinnervation for real-time myoelectric control of multifunction artificial arms
    Todd A Kuiken
    Neural Engineering Center for Artificial Limbs, Rehabilitation Institute of Chicago, 345 E Superior St, Room 1309, Chicago, IL 60611, USA
    JAMA 301:619-28. 2009
    ..prosthetic arms remains a challenge, because access to the neural-control information for the arm is lost during amputation. A surgical technique called targeted muscle reinnervation (TMR) transfers residual arm nerves to alternative ..
  89. ncbi Apotemnophilia masquerading as medical morbidity
    J Mike Bensler
    Division of General Internal Medicine, Department of Medicine, University of Washington Medical Center, Seattle, WA 98195 6420, USA
    South Med J 96:674-6. 2003
    We report a case of apotemnophilia, or "love of amputation," in a man in his mid-20s...
  90. ncbi Indications for amputations in Ile-Ife, Nigeria
    A A Olasinde
    Department of Orthopaedic Surgery, Obafemi Awolowo University Teaching Hospitals Complex, Ile Ife
    Niger J Med 11:118-21. 2002
    ..Trauma was indicated as a reason for amputation in 60 patients (73.4%)...
  91. pmc Risk of amputation following limb salvage surgery with endoprosthetic replacement, in a consecutive series of 1261 patients
    L M Jeys
    Royal Orthopaedic Hospital Oncology Service, Bristol Road South, Northfield, Birmingham, B31 2AP United Kingdom
    Int Orthop 27:160-3. 2003
    ..Increasing problems may lead to the necessity for amputation; this paper assesses that risk...
  92. pmc Sex differences in pain and psychological functioning in persons with limb loss
    Adam T Hirsh
    Department of Rehabilitation Medicine, University of Washington School of Medicine, Seattle, WA 98195 6490, USA
    J Pain 11:79-86. 2010
    ..This study did not find prominent sex differences in pain specific to limb loss. However, several sex differences in the overall biopsychosocial experience of pain did emerge that are consistent with the broader literature...
  93. ncbi Cell proliferation during blastema formation in the regenerating teleost fin
    Leonor Santos-Ruiz
    Department of Cell Biology and Genetics, Faculty of Sciences, University of Malaga, Malaga, Spain
    Dev Dyn 223:262-72. 2002
    ..cell proliferation patterns in the regenerating fin of the goldfish Carassius auratus from the time of amputation to that of blastema formation by using proliferating cell nuclear antigen immunostaining and bromodeoxyuridine ..
  94. ncbi Pain site and the effects of amputation pain: further clarification of the meaning of mild, moderate, and severe pain
    M P Jensen
    Department of Rehabilitation Medicine, Box 356490, University of Washington School of Medicine, Seattle, WA 98195 6490, USA
    Pain 91:317-22. 2001
    ..that have been identified as optimal for cancer patients are also optimal for persons with pain associated with amputation, and determine whether the optimal cutoffs replicate across pain types (in this case, phantom limb, back, and ..
  95. pmc Lower-extremity amputation risk after charcot arthropathy and diabetic foot ulcer
    Min Woong Sohn
    Center forManagement of Complex Chronic Care, Hines Veterans Affairs Hospital, Hines, Illinois, USA
    Diabetes Care 33:98-100. 2010
    To compare risks of lower-extremity amputation between patients with Charcot arthropathy and those with diabetic foot ulcers.
  96. pmc Autologous bone marrow mononuclear cell therapy is safe and promotes amputation-free survival in patients with critical limb ischemia
    Michael P Murphy
    Department of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202 1228, USA
    J Vasc Surg 53:1565-74.e1. 2011
    ..of this Phase I open label nonrandomized trial was to assess the safety and efficacy of autologous bone marrow mononuclear cell (ABMNC) therapy in promoting amputation-free survival (AFS) in patients with critical limb ischemia (CLI).
  97. ncbi Mind-body interventions for treatment of phantom limb pain in persons with amputation
    Vera Lucia Moura
    Department of Physical Medicine and Rehabilitation, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Am J Phys Med Rehabil 91:701-14. 2012
    Phantom limb pain (PLP) is a significant source of chronic pain in most persons with amputation at some time in their clinical course...
  98. ncbi Randomized prospective study comparing preoperative epidural and intraoperative perineural analgesia for the prevention of postoperative stump and phantom limb pain following major amputation
    C Cosgrove
    Vascular Surgery Unit and Department of Anaesthesia, Derriford Hospital, Plymouth, United Kingdom
    Reg Anesth Pain Med 26:316-21. 2001
    BACKGROUND AND OBJECTIVES: Acute stump pain and phantom limb pain after amputation is a significant problem among amputees with a reported incidence of phantom limb pain in the first year following amputation as high as 70%...
  99. ncbi Clinical and social consequences of Buerger disease
    Takashi Ohta
    Department of Vascular Surgery, Aichi Medical University, 21 Karimata, Yazako, Nagakute, 480 1195 Aichi, Japan
    J Vasc Surg 39:176-80. 2004
    ..This study was undertaken to assess the clinical course of Buerger disease and to analyze the social problems that influence quality of life of affected patients...
  100. ncbi Peripheral arterial disease in diabetes--a review
    E B Jude
    Tameside General Hospital, Ashton under Lyne, Lancashire, UK
    Diabet Med 27:4-14. 2010
    ..b>Amputation rates are higher due to the distal nature of the disease...
  101. ncbi Improvement of diabetic foot care after the Implementation of the International Consensus on the Diabetic Foot (ICDF): results of a 5-year prospective study
    Roberto Anichini
    Division of Diabetes and Diabetes Foot Unit, General Hospital of Pistoia AUSL n 3, Pistoia, Italy
    Diabetes Res Clin Pract 75:153-8. 2007
    ..This study shows the advantages of prospective data collection, demonstrating that the implementation of the International Consensus on the Diabetic Foot can improve foot care in diabetes...

Research Grants77

  1. Exercise training and blood pressure in hypertension: integrated mechanisms
    Noreen F Rossi; Fiscal Year: 2012
    ..lifestyle is widespread and many veterans suffer from injuries or diseases that limit dynamic exercise: amputation, paralysis, peripheral vascular disease, cardiopulmonary disorders, and even depression...
  2. Ligand Directed Transdermal siRNA Delivery to Improve Wound Healing
    David M Evans; Fiscal Year: 2012
    ..in the United States, and approximately 14-24 % of patients with diabetes who develop a foot ulcer will have an amputation. Wounds in the elderly are also slower to heal and the problem is especially compounded in elderly diabetics...
  3. Improved Adventitial Sirolimus Therapy for Peripheral Artery Restenosis
    KIRK SEWARD; Fiscal Year: 2010
    ..5 million will require an intervention (407,400 receive bypass or amputation;1,080,000 receive angioplasty, stent or atherectomy) each year [3]...
  4. Na+/H+-exchanger-1 and Diabetic Neuropathy
    MARK ANTHONY YOREK; Fiscal Year: 2012
    ..diabetic neuropathy (PDN) is the most devastating complication of diabetes mellitus, and a leading cause of foot amputation. Evidence for importance of free radicals and oxidants in PDN is emerging from both animal and human studies, ..
  5. Fall risk assessment and prevention in elderly with diabetes using wearable techn
    Bor Rong Chen; Fiscal Year: 2012
    ..Diabetes prevalence is estimated to increase to 33% in US [5]. Insulin use is associated with a 90% increased amputation risk [6] and 2.8 increased fall risk [7]; an important emerging risk factor for foot ulcer non-healing...
  6. MicroRNA Regulation of Macrophage Polarization in Muscle Regeneration
    Paula K Shireman; Fiscal Year: 2013
    ..observed in Iraqi/Afghanistan War Veterans resulting in large soft tissue defects (muscle and skin) and high amputation rates...
  7. Characterizing Ankle Function During Sloped Locomotion For Prosthesis Development
    Alena Grabowski; Fiscal Year: 2012
    DESCRIPTION: For the first time in history, people with a lower limb amputation have regained normative function during level-ground walking due to the development of a new powered ankle-foot prosthesis...
  8. Regulation of Bacteroides fragilis multidrug efflux pumps
    Hannah Wexler; Fiscal Year: 2013
    ..pump activity;these isolates were resistant to metronidazole and other agents and resulted in one death and one amputation, respectively. Preliminary Studies: In the previous funding period, we identified and characterized the B...
  9. Improve Wound Healing with HIF-CA5 DNA Vector and Electroporation
    John W Harmon; Fiscal Year: 2010
    ..These non-healing ulcerations on the foot are disabling, and their progression leads to amputation of the lower extremity. Diabetes is the most frequent cause for lower extremity amputation in the United States...
  10. Neurorestorative Strategy for Diabetic Peripheral Neuropathy
    Feng Qiao Li; Fiscal Year: 2013
    ..of diabetes mellitus, affecting more than 50% of diabetic patients, and is the leading cause of foot amputation. DPN, characterized by peripheral axonal degeneration and demyelination, can be disabling and extremely painful, ..
  11. Dietary Nitrate to Augment Exercise Training Benefits in DM+PAD
    Jason David Allen; Fiscal Year: 2013
    ..DM+PAD patients are at increased risk for disease progression to critical leg ischemia, lower extremity amputation, and cardiovascular events...
  12. Development of Adult Pluripotent Very Small Embryonic Like (VSEL) Stem Cells to T
    DENIS OVEREND RODGERSON; Fiscal Year: 2013
    ..making the ulcers difficult to heal, prone to infection and progression to gangrene can occur that requires amputation. The ischemic ulcers are frequent, painful, and cause significant morbidity...
  13. Stem Cell Based Therapy for Regenerative Endodontics
    George T J Huang; Fiscal Year: 2013
    ..There have been no other effective ways to repair the infected or injured pulp tissue besides complete amputation. Recent advances in pulp stem cell isolation and tissue engineering technologies have shed light on the ..
  14. Genetic contributors to diabetes and dyslipidemia in African Americans
    Michele M Sale; Fiscal Year: 2010
    ..and leads to a devastating range of complications, including heart attack, stroke, kidney failure, blindness, amputation, and nerve pain. Given current trends, 40-49 percent of AA born in 2000 will develop T2DM in their lifetime...
  15. Development of Cytokine-Inhibiting Gels for Treating Chronic Wounds
    Newell R Washburn; Fiscal Year: 2010
    ..Diabetic foot ulcers cost tens of thousands of dollars to treat and are the leading cause of lower extremity amputation. While there is a broad range of treatment options available - ranging from debridement to application of ..
  16. Intracellular Targeting of Proinflammatory Pathways to Ameliorate Type 1 Diabetes
    Daniel J Moore; Fiscal Year: 2010
    ..and even compliant patients are not always protected from complications such as blindness, renal failure, and amputation. Our current understanding of the disease paints a complex picture in which nearly every immune cell is involved...
  17. Modulated Imaging in Comprehensive Assessment of Diabetic Foot Ulcer Development
    Amaan Mazhar; Fiscal Year: 2012
    ..Untreated diabetic foot ulceration and subsequent amputation has a profound impact on the quality of life of the diabetic patient...
  18. Wound EMR to Decrease Limb Amputations in Persons with Diabetes
    Harold Brem; Fiscal Year: 2010
    ..Persons with diabetes have a high risk of developing chronic non-healing DFUs that progress to lower-limb amputation, disability and loss of life...
  19. Skin Temperature Perception and Prosthetic Thermoregulation
    GLENN KLUTE; Fiscal Year: 2012
    ..Specific Aim 1 will identify perception thresholds to thermal stimuli and the existence of any amputation- or diabetic-related thermoregulatory impairment...
  20. Epigenetic Biomarkers of Common Chronic Diseases
    Sharon L Kardia; Fiscal Year: 2010
    ..or kidney disease identify individuals with high risk of debilitating clinical outcomes, such as extremity amputation and dialysis, there is a pressing need to identify at-risk individuals well before the presentation of clinical ..
  21. BEST-CLI Trial-CCC-Lead
    Kenneth Rosenfield; Fiscal Year: 2013
    ..Canada - BEST - comparing best open surgery to best endovascular revascularization to prevent mortality, limb-amputation or further revascularization in a target limb with critical limb ischemia (CLI), meeting the current mandate for ..
  22. Attenuation of Ischemia-Reperfusion Injury in Limb Auto- and Allografts
    GEOFFROY COURCELLE SISK; Fiscal Year: 2013
    ..Thus, the potential for tissue death due to IRI in transplanted and replanted tissues is enormous. Traumatic amputation (TA) is the 2nd leading cause of limb loss in the U.S...
  23. Genome-wide fine-mapping of metabolic traits in heterogeneous stock rats
    LEAH CATHERINE SOLBERG WOODS; Fiscal Year: 2013
    ..T2D is a leading cause of kidney failure, blindness and limb amputation and a major risk factor for heart disease and stroke (18)...
  24. Micro-RNA Molecules as Regulators of Diabetic Wound Healing
    Marjana Tomic-Canic; Fiscal Year: 2013
    ..Diabetic foot ulcers (DFUs) are one of the major complications of diabetes mellitus leadin to lower extremity amputation for thousands of diabetic persons each year...
  25. MASP-2 Antibodies for Diabetic Neuropathy
    THOMAS ANTON DUDLER; Fiscal Year: 2012
    ..term diabetes and accounts for significant morbidity by predisposing the foot to ulceration and lower extremity amputation. A progressive loss of peripheral nerve function is the underlying cause...
  26. TNF-ALPHA AND BMP2-WNT SIGNALING IN DIABETIC VASCULAR DISEASE
    Dwight A Towler; Fiscal Year: 2012
    ..perturbs normal Windkessel physiology, causing systolic &diastolic dysfunction that increases mortality &amputation risk. The ability to prevent or treat MAC represents an unmet clinical need...
  27. Role of Femoral Atherosclerosis in Functional Status, CVD Events, and Mortality
    CHRISTINA LYNN WASSEL; Fiscal Year: 2013
    ..Furthermore, intermittent claudication, critical leg ischemia, and amputation resulting from PAD adversely affect quality of life and functional status...
  28. OSTEOGENIC REGULATION OF VASCULAR CALCIFICATION
    Dwight A Towler; Fiscal Year: 2012
    ..In patients with type II diabetes (T2DM), medial artery calcification is a powerful index of lower extremity amputation risk;arteriosclerotic medial calcification is a much more ominous predictor of amputation than atherosclerotic ..
  29. BEST-CLI Trial-DCC
    Flora Sandra Siami; Fiscal Year: 2013
    ..Canada - BEST - comparing best open surgery to best endovascular revascularization to prevent mortality, limb-amputation or further revascularization in a target limb with critical limb ischemia (CLI), meeting the current mandate for ..
  30. Peroxynitrite, protein nitration and advanced diabetic neuropathy
    Mark A Yorek; Fiscal Year: 2013
    ..diabetic neuropathy (PDN) is the most devastating complication of diabetes mellitus, and a leading cause of foot amputation. Evidence for important role of peroxynitrite (a product of superoxide reaction with nitric oxide) in PDN is ..
  31. Effect of Prosthetic Foot-Ankle Stiffness on Amputee Function
    GLENN KLUTE; Fiscal Year: 2011
    ..of the Proposed Work to the VA Patient Care Mission VA surgeons perform between 3000 and 5000 lower limb amputation procedures each year (Mayfield et al., 2000)...
  32. Transcriptome resources for a cephalopod model system
    Clifton W Ragsdale; Fiscal Year: 2013
    ..system is that octopus arms, each of which contains a massive central nervous system, regenerate rapidly after amputation and could serve as a new model in regenerative medicine...
  33. A comparative efficacy study: treatments of non-healing diabetic foot ulcers
    Roslyn R Isseroff; Fiscal Year: 2013
    ..common complications of adults with diabetes, occurring in about 15-20% of diabetics, and often leading to foot amputation. The resulting diabetic foot ulcers (DFU) and subsequent amputations generate significant patient morbidity and ..
  34. Exploring Sarcoma Metastatic Potential
    KURT RICHARD WEISS; Fiscal Year: 2013
    ..Dr. Weiss has also experienced the difficulties of sarcoma surgery which culminated in the amputation of his right leg...
  35. The role of HMGB-1 and innate immunity in promoting angiogenesis after ischemia
    Ulka Sachdev; Fiscal Year: 2013
    ..With increasing severity of arterial occlusive disease in the leg, critical limb ischemia can occur resulting in amputation in up to 40% of patients with non-reconstructable disease...
  36. Role of SMRT and NCoR in adipocyte differentation and function
    Ronald N Cohen; Fiscal Year: 2012
    ..for the development of type 2 diabetes mellitus, and diabetes is a major cause or blindness, kidney disease, amputation, and death...
  37. Comparative Effectiveness of Adjunctive Devices For the Previous
    David J Margolis; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Lower extremity amputation (LEA) is a very severe and catastrophic complication of diabetes mellitus...
  38. Cell therapy for diabetic peripheral neurovascular complications
    YOUNG SUP contact YOON; Fiscal Year: 2011
    ..disease of the lower extremities, and when advanced into the critical limb ischemia stage, can often lead to leg amputation. As advanced PAD in diabetes frequently affects small vessels, conventional percutaneous intervention and ..
  39. Developing a brain-machine interface for an ankle robot
    Larry Forrester; Fiscal Year: 2012
    ..among Veterans and others who are disabled after stroke and other neurological injuries, as well as lower limb amputation. In the Baltimore VA's Maryland Exercise and Robotics Center of Excellence, we have developed an impedance ..
  40. Clinical Research Center to Decrease Limb Amputation Rate in People with Diabetes
    Harold Brem; Fiscal Year: 2013
    ....
  41. MSX2-Wnt Signaling in Cardiovascular Calcification
    Dwight A Towler; Fiscal Year: 2013
    ..medial calcific sclerosis - has emerged as a particularly important contributor to lower extremity (LE) amputation risk in type II diabetes (T2DM)...
  42. Mechanisms of Neuropeptides Action in Diabetes
    JANICE ZABOLOTNY; Fiscal Year: 2013
    ..healing and this may be of the major reasons that lead to the development of chronic DFU that may necessitate amputation. In the present application we plan to identify the mechanisms through which, the neuropathy-associated lack of ..
  43. A Biomimetic Prehensile Digit for Upper-Limb Prostheses
    BRADLEY D VEATCH; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Among amputation types involving the upper limbs, partial hand is the most prevalent by far and among the most challenging for prosthetists to address well...
  44. Bone marrow-derived fibroblasts in skin wound healing
    Omaida C Velazquez; Fiscal Year: 2010
    ..Nearly 25% of all diabetic patients, with foot ulcers, will inevitably progress to major limb amputation. Diabetic wound healing deficiencies are associated with impaired tissue level neovascularization, impaired ..
  45. CNS Mechanisms Controlling Blood Glucose Levels in Uncontrolled Diabetes Mellitus
    THOMAS HARRIS MEEK; Fiscal Year: 2013
    ..with a higher risk of cardiovascular disease and both macro- and micro-vascular disease including blindness, amputation and renal disease...
  46. Clinical Trial of Antimicrobial Skin to treat Diabetic Ulcers
    Mary A Lokuta; Fiscal Year: 2013
    ..For the diabetic patient, amputation of one limb is associated with a poor prognosis for the contralateral limb, and a decreased rate of survival in ..
  47. Development of an Antimicrobial Cellular Therapeutic for Inhibition of Biofilm Fo
    ALLEN R COMER; Fiscal Year: 2013
    ..of US citizens and are associated with increased risk of complications including the devastating consequence of amputation. As of 2006, infections of diabetic foot ulcers resulted in 82,000 amputations each year and it has been ..
  48. Reprogramming Cells to Enable Limb Regeneration
    JONATHAN M SLACK; Fiscal Year: 2012
    ..Tadpoles of the frog Xenopus laevis are normally able to regenerate their limbs following amputation at early developmental stages but not at later stages...
  49. Foot Progression Angle in Individuals with Diabetes &Peripheral Neuropathy
    ERICKA NAYRAM MERRIWETHER; Fiscal Year: 2013
    ..is frequently used as a proxy measure of risk for skin breakdown and subsequent non-traumatic lower extremity amputation. Preliminary studies suggest a direct relationship between excessive external FPA and the timing and magnitude ..
  50. Search for new MODY genes and molecular studies of their function in beta cells
    Rohit N Kulkarni; Fiscal Year: 2013
    ..in treatment, diabetes continues to be the leading cause of chronic renal failure, adult blindness and limb amputation, and a major risk factor for heart disease, stroke and birth defects...
  51. DEVICE FOR PROMOTING SURVIVAL OF CONGESTED TISSUE FLAPS
    John A Russell; Fiscal Year: 2010
    ..and/or reconstruction after cancer resection, limb transplantation, breast reconstruction, and traumatic amputation, avulsion, or gunshot injury. Venous congestion is a serious complication of these types of procedures...
  52. Predicting Skeletal Stability of Endoprostheses for Above Elbow Amputees
    Kent N Bachus; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Project Summary Limb amputation is a devastating event with an associated loss of every day function coupled with a dramatic change of life. In the United States alone, 1...
  53. Preparation of a Monograph on Targeted Reinnervation
    TODD ALAN KUIKEN; Fiscal Year: 2013
    ..reinnervation is a surgical technique that has created a revolutionary change in the treatment of upper-limb amputation. In targeted muscle reinnervation (TMR), truncated arm nerves are connected to spare (target) muscles, creating ..
  54. Prevention of Biofilm Related Infections Using a Novel, Broad Spectrum Antimicrob
    ROY DRAKE BLOEBAUM; Fiscal Year: 2013
    ..infections are not only costly to healthcare systems, but cripple individual lives and may even lead to amputation. Evolving bacterial resistance to antibiotics and the limitations of antibiotics when used as implant surface ..
  55. CAD-CAM TECHNOLOGY FOR DIABETIC FOOTWEAR
    JOSEPH L LOOMIS; Fiscal Year: 2010
    ..insoles that redistribute load and therefore reduce pressure should reduce plantar ulcer rates and therefore amputation risk...
  56. Therapeutic Intermittent Compression Socket
    TODD RICHARD FARRELL; Fiscal Year: 2010
    ..provided by applicant): Providing rapid intermittent compression (IC) therapy to persons with dysvascular amputation should reduce the number of reamputations that are performed by increasing blood flow to the residual limb...
  57. Developing the Anolis Lizard as a Model of Musculoskeletal Regeneration
    Kenro Kusumi; Fiscal Year: 2011
    ..PUBLIC HEALTH RELEVANCE: Lizards display the remarkable ability to regenerate their tails after self-amputation, forming new muscle groups and hyaline cartilage, which is a tissue that are currently difficult to medically ..
  58. Pneumatic Medicine: A transformative treatment for diabetic peripheral neuropathy
    LAURA F JACOBS; Fiscal Year: 2010
    ..improve sensation in DPN patients would decrease the patient's risk for foot ulceration and lower-extremity amputation, and improve the patient's overall prognosis and quality of life...
  59. Mechanisms for Wound Healing with Ultrasound
    Denise C Hocking; Fiscal Year: 2012
    ..specific wound healing pathways would greatly reduce healthcare and economic costs, lessen the chance of amputation, and improve the quality of life of patients with chronic wounds...
  60. Ultrasound-induced Thermal Strain Imaging for Arterial Plaque Characterization
    Kang Kim; Fiscal Year: 2013
    ..model, water tank experiments using the tissue mimicking phantoms, the human tissue specimens from autopsy, amputation and carotid endarterectomy (CEA), and high cholesterol-fed rabbit model...
  61. Corneal Confocal Microscopy: a non-invasive surrogate for diabetic neuropathy
    RAYAZ AHMED MALIK; Fiscal Year: 2012
    ..long-term complications of diabetes and is a main initiating factor for foot ulceration and lower extremity amputation. Current techniques for the quantification of neuropathy either lack sensitivity (quantitative sensory testing), ..
  62. ZeroG: Dynamic Over-Ground Body-Weight Support System
    Joseph Hidler; Fiscal Year: 2009
    ..common to individuals following stroke, multiple sclerosis (MS), cerebral palsy (CP), spinal cord injury (SCI), amputation, and normal complications related to general aging...
  63. ACTIVE SPECIFIC IMMUNOTHERAPY IN MAN--A MURINE MODEL
    Barry Kahan; Fiscal Year: 1992
    ..mm) day established MCA-F subcutaneous neoplasms, and almost vitiated spontaneous pulmonary metastases following amputation of a limb bearing the MCA-F-4 (lung avid) tumor...
  64. DIABETIC NEUROPATHIC FOOT ULCER: WHO WILL HEAL?
    David Margolis; Fiscal Year: 2003
    ..occur in patients with diabetes, thereby making diabetes the leading cause of lower extremity non-traumatic amputation. Lower extremity chronic wounds precede more than 85% of these amputations...
  65. Development of a biodegradable load-bearing DBM carrier
    TIEN MIN CHU; Fiscal Year: 2006
    ..In case of treatment failure, alternative treatment may involve serious consequences such as leg shortening or amputation. To overcome the limitations in these treatment options, we are exploring tissue engineering...
  66. Clinical Implications of Peripheral Plaque Morphology
    Daniel Clair; Fiscal Year: 2007
    ..It is responsible for incapacitating symptoms of leg pain when walking, culminating in amputation in a small proportion of patients...
  67. EARLY HEMICRANIECTOMY TO MANAGE TRAUMATIC BRAIN INJURY
    William Coplin; Fiscal Year: 1999
    ..The current standard of initial surgical care includes evacuation of intracranial hematomas, and, often amputation of swollen confused brain...
  68. FDG-PET Imaging in Complicated Diabetic Foot
    Abass Alavi; Fiscal Year: 2005
    ..of these patients, because prompt antibiotic treatment cure infection and therefore can decrease the rate of amputation. However, establishing the diagnosis of osteomyelitis is quite difficult in this setting because of concurrent ..
  69. Restoring upper limb movement sense to amputees;a move towards natural control o
    Paul Marasco; Fiscal Year: 2012
    ..to create dexterous, multi- functional, prosthetic limbs for restoration of upper limb function following amputation. The focus on prosthetic limb development has, has in many ways, been fueled by advances in clinically ..
  70. Development of Extraocular Muscle Prosthesis for Paralytic Strabismus
    Yasushi Kato; Fiscal Year: 2009
    ..encountered with increasing frequency in functional endoscopic sinus surgery (FESS) is the inadvertent amputation of the medial rectus muscle...
  71. EMG propagation in planar muscles for prosthesis control
    Todd Kuiken; Fiscal Year: 2007
    ..This is very inadequate, especially for high-levels of amputation such as shoulder disarticulation(SD) where multiple functions need to be controlled...
  72. Metabolic MRI of Diabetic Lower Extremity Disease
    Robert L Greenman; Fiscal Year: 2010
    ..of localized capillary beds often result in foot ulcers that do not heal leading to infection, osteomyelitis and amputation. Methods of identifying individuals who are at risk of developing complications at the foot level include ..
  73. Evaluation of a novel connexin-based peptide for the treatment of diabetic wounds
    Gautam Ghatnekar; Fiscal Year: 2007
    ..the patient's quality of life, require prolonged hospitalization, and may involve infection, gangrene, and amputation. It has been estimated that for each new foot ulcer the attributable cost for a middle-aged diabetic man in the ..
  74. BLOOD FACTORS AND PERIPHERAL ARTERIAL DISEASE OUTCOMES
    Mary McDermott; Fiscal Year: 2004
    ..15, lower extremity gangrene, ulcer, revascularization, or amputation);, b) functional decline over 48 month follow-up...
  75. ActiveImplant Prosthesis for Lower Limb Amputees
    JOHN FAGO; Fiscal Year: 2007
    ..Current surgical techniques for amputation of the distal femur above the knee do not provide an optimum solution for interfacing with a prosthetic socket ..
  76. Clinical Testing of Hyperspectral Assessment & Prediction of Diabetic Foot Ulcers
    KEVIN SCHOMACKER; Fiscal Year: 2007
    ..HYPERMED'S long-term objective is to reduce frequency of foot ulcers & amputation by developing Foot HyperSpectral Imaging (FHSI) as a camera-based system to 1) identify tissue at risk for ..