Genomes and Genes
protein restricted diet
Summary: A diet that contains limited amounts of protein. It is prescribed in some cases to slow the progression of renal failure. (From Segen, Dictionary of Modern Medicine, 1992)
Publications222 found, 100 shown here
- Programming of intermediary metabolismC J Petry
Department of Clinical Biochemistry, Addenbrooke's Hospital, University of Cambridge, Hills Road, Cambridge CB2 2QR, UK
Mol Cell Endocrinol 185:81-91. 2001..Alterations in intermediary metabolism were noted in the rats with early growth restriction, which provide support for our hypothesis and clues to the mechanism...
- Down-regulation of placental transport of amino acids precedes the development of intrauterine growth restriction in rats fed a low protein dietNina Jansson
Perinatal Center, Institute of Neuroscience and Physiology, Goteborg University, Sweden
J Physiol 576:935-46. 2006..Reduced maternal levels of insulin, leptin and IGF-1 may link maternal protein malnutrition to reduced fetal growth by down-regulation of key placental amino acid transporters...
- Special low-protein foods ameliorate postprandial off in patients with advanced Parkinson's diseaseMichela Barichella
Clinical Nutrition Unit, Istituti Clinici di Perfezionamento, Milan, Italy
Mov Disord 21:1682-7. 2006..8%) was observed. Consumption of LPP in the first part of the day ameliorates off periods in PD patients, but additional studies including pharmacokinetics are needed...
- Prenatal exposure to a maternal low protein diet shortens life span in ratsA Aihie Sayer
MRC Environmental Epidemiology Unit, Southampton General Hospital, University of Southampton, Southampton General Hospital, Southampton, UK
Gerontology 47:9-14. 2001..It remains unclear whether life span is similarly adversely affected by early diet restriction...
- Protein restriction without strong caloric restriction decreases mitochondrial oxygen radical production and oxidative DNA damage in rat liverAlberto Sanz
Department of Animal Physiology II, Faculty of Biological Sciences, Complutense University, Madrid, 28040, Spain
J Bioenerg Biomembr 36:545-52. 2004..Interestingly, these tissue oxidative stress-linked parameters can be lowered by restricting only the intake of dietary protein, probably a more feasible option than caloric restriction for adult humans...
- The effects of maternal protein restriction on the growth of the rat fetus and its amino acid supplyW D Rees
Rowett Research Institute, Bucksburn, Aberdeen, UK
Br J Nutr 81:243-50. 1999..Possible mechanisms for the decrease in free threonine in both mother and fetuses and the consequences of the change in amino acid metabolism are discussed...
- Effect of a low-protein diet during pregnancy on skeletal muscle mechanical properties of offspring ratsAna Elisa Toscano
Departmento de Nutrição, Universidade Federal de Pernambuco, Recife, Brazil
Nutrition 24:270-8. 2008..The main goal of the present study was to investigate the effects of a low-protein diet during gestation on the biomechanical properties of skeletal muscle of offspring rats...
- Dietary protein restriction benefits patients with chronic kidney diseaseSreedhar Mandayam
Nephrology Division, University of Texas Medical Branch, Galveston, USA
Nephrology (Carlton) 11:53-7. 2006..Until a means of preventing kidney disease or progression is found, safe methods of management such as dietary manipulation should be available for CKD patients...
- Dietary protein restriction decreases oxidative protein damage, peroxidizability index, and mitochondrial complex I content in rat liverVictoria Ayala
Department of Basic Medical Sciences, Faculty of Medicine, University of Lleida, Spain
J Gerontol A Biol Sci Med Sci 62:352-60. 2007..Recent studies suggest that those benefits of PR could be caused, in turn, by the lowered methionine intake of that dietary manipulation...
- Effect of dietary protein restriction on the progression of kidney disease: long-term follow-up of the Modification of Diet in Renal Disease (MDRD) StudyAndrew S Levey
Division of Nephrology, Tufts New England Medical Center, Tufts University School of Medicine, Boston, MA 02111, USA
Am J Kidney Dis 48:879-88. 2006..We evaluated effects of protein restriction on kidney failure and all-cause mortality during extended follow-up of the Modification of Diet in Renal Disease Study...
- Dietary protein restriction as a treatment for slowing chronic kidney disease progression: the case againstDavid W Johnson
Department of Renal Medicine, University of Queensland at Princess Alexandra Hospital, Brisbane, Australia
Nephrology (Carlton) 11:58-62. 2006..g. renin-angiotensin system blockade, blood pressure reduction and statin therapy)...
- Geometric analysis of macronutrient intake in humans: the power of protein?Stephen J Simpson
Department of Zoology and University Meseum of Natural History, University of Oxford, South Parks Road, Oxford OX1 3PS, UK
Appetite 41:123-40. 2003....
- Maternal protein restriction leads to early life alterations in the expression of key molecules involved in the aging process in rat offspringMalgorzata S Martin-Gronert
Department of Clinical Biochemistry, Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
Am J Physiol Regul Integr Comp Physiol 294:R494-500. 2008..MnSOD expression was increased in these animals. These data suggest that early nutrition can lead to alterations in insulin sensitivity and antioxidant capacity very early in life, which may influence life span...
- Maternal protein restriction increases hepatic glycogen storage in young ratsAlison K Gosby
Human Nutrition Unit, School of Molecular and Microbial Biosciences, University of Sydney, Sydney NSW 2006, Australia
Pediatr Res 54:413-8. 2003..The enhanced capacity to store glycogen despite reductions in insulin secretion suggests increased insulin sensitivity possibly acting with an alternative non-insulin-dependent glycogen storage mechanism...
- Effect of a very low-protein diet on outcomes: long-term follow-up of the Modification of Diet in Renal Disease (MDRD) StudyVandana Menon
Department of Medicine, Division of Nephrology, Tufts Medical Center, Boston, MA, USA
Am J Kidney Dis 53:208-17. 2009..We examined the effect of a very low-protein diet on the development of kidney failure and death during long-term follow-up of the Modification of Diet in Renal Disease (MDRD) Study...
- Dietary protein restriction causes modification in aluminum-induced alteration in glutamate and GABA system of rat brainPrasunpriya Nayak
Department of Physiology, Sikkim Manipal Institute of Medical Sciences, 5th Mile, Tadong, Gangtok 737102, Sikkim, India
BMC Neurosci 4:4. 2003..Thus the region-wise study of levels of brain glutamate and gamma-aminobutyrate system in protein adequacy and inadequacy may be worthwhile to understand the mechanism of aluminum-induced neurotoxicity...
- The influence of simultaneous whole body exposure to cigarette smoke and low-protein diet feeding on fertility, reproduction, and progeny of ratsE Florek
Department of Toxicology, Karol Marcinkowski University of Medical Sciences, Poznan 60 631, Poland
Hum Exp Toxicol 21:615-21. 2002..This influence was mainly attributed to the tobacco smoke exposure. The levels of carboxyhaemoglobin were increasing with increasing tobacco smoke concentration...
- Interactions between protein and vegetable oils in the maternal diet determine the programming of the insulin axis in the ratChristopher A Maloney
Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen, AB21 9SB, UK
Br J Nutr 97:912-20. 2007..The present study suggests that PUFA in the maternal diet can interact with protein metabolism to influence the development of the offspring. This may involve the higher content of alpha-linolenic acid in soya oil compared with corn oil...
- Fetal exposure to a maternal low-protein diet during mid-gestation results in muscle-specific effects on fibre type composition in young ratsJoanne E Mallinson
Division of Nutritional Sciences, School of Biosciences, University of Nottingham, Sutton Bonington, Loughborough, LE12 5RD, UK
Br J Nutr 98:292-9. 2007..In conclusion, a maternal low-protein diet mainly during mid-pregnancy reduced muscle fibre number and density in 4-week-old rats, but there were muscle-specific differences in the fibre types affected...
- Glycine rectifies vascular dysfunction induced by dietary protein imbalance during pregnancyL Brawley
Centre for Developmental Origins of Health and Disease, Princess Anne Hospital, Coxford Road, Southampton SO16 5YA, UK
J Physiol 554:497-504. 2004....
- Maternal low-protein diet programs cardiac beta-adrenergic response and signaling in 3-mo-old male offspringDenise S Fernandez-Twinn
Department of Clinical Biochemistry, University of Cambridge, Addenbrookes Hospital, Hills Road, Cambridge, UK
Am J Physiol Regul Integr Comp Physiol 291:R429-36. 2006..012). LP offspring have reduced beta-adrenergic responsiveness and attenuated adrenergic and insulin signaling, suggesting that intrauterine undernutrition alters heart failure risk...
- Oats and the gluten-free dietTricia Thompson
J Am Diet Assoc 103:376-9. 2003..Ideally, if a patient appears likely to use oats, they should be advised to consume only those products tested and found to be free of contamination...
- Site-specific changes in the expression of fat-partitioning genes in weanling rats exposed to a low-protein diet in uteroChris A Maloney
Human Nutrition Unit, School of Molecular and Microbial Biosciences, University of Sydney, Sydney, New South Wales, Australia
Obes Res 11:461-8. 2003..The aim of this study was to investigate if maternal protein energy malnutrition is associated with changes in expression of genes involved in fat partitioning in weanling rats...
- Dietary protein restriction of pregnant rats in the F0 generation induces altered methylation of hepatic gene promoters in the adult male offspring in the F1 and F2 generationsGraham C Burdge
Developmental Origins of Health and Disease Division, University of Southampton, Southampton, UK
Br J Nutr 97:435-9. 2007..This may represent a mechanism for the transmission of induced phenotypes between generations..
- Dietary protein restriction in pregnancy induces hypertension and vascular defects in rat male offspringLee Brawley
Centre for Fetal Origins of Adult Disease, Princess Anne Hospital, Coxford Road, Southampton SO16 5YA, U K
Pediatr Res 54:83-90. 2003..Reduced vasodilation may be a potential mechanism underlying the elevated systolic blood pressure observed in this model...
- Adaptive changes in thyroid function of female rats fed a high-fat and low-protein diet during gestation and lactationP D Brito
Departamento de Ciencias Fisiologicas, Instituto de Biologia, Universidade do Estado do Rio de Janeiro, RJ, Brasil
Braz J Med Biol Res 39:809-16. 2006....
- Exaggerated vasomotor response to ANG II in rats with fetal programming of hypertension associated with exposure to a low-protein diet during gestationC Yzydorczyk
Research Center, Hopital Sainte Justine, Department of Pediatrics, Universite de Montreal, Montreal, Quebec, Canada, H3T 1C5
Am J Physiol Regul Integr Comp Physiol 291:R1060-8. 2006....
- Long-term effect of early protein malnutrition on growth curve, hematological parameters and macrophage function of ratsLuiz Euribel Prestes-Carneiro
Department of Immunology, University of Oeste Paulista, Presidente Prudente, Brazil
J Nutr Sci Vitaminol (Tokyo) 52:414-20. 2006....
- Sex differences in transgenerational alterations of growth and metabolism in progeny (F2) of female offspring (F1) of rats fed a low protein diet during pregnancy and lactationE Zambrano
Department of Reproductive Biology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran Vasco de Quiroga 15, 14000, Mexico, DF Mexico
J Physiol 566:225-36. 2005....
- Adipose tissue gene expression profiling reveals distinct molecular pathways that define visceral adiposity in offspring of maternal protein-restricted ratsHaiyan Guan
Department of Obstetrics and Gynaecology, Canadian Institutes of Health Research Group in Fetal and Neonatal Health and Development, Children s Health Research Institute, University of Western Ontario, Canada
Am J Physiol Endocrinol Metab 288:E663-73. 2005..Our data provide new insights into the molecular mechanisms that underlie the early-life programming of visceral adiposity...
- Prenatal dietary docosahexaenoic acid supplementation in combination with protein restriction does not affect blood pressure in adult Wistar ratsD A Martin
Department of Health Studies and Gerontology, University of Waterloo, 200 University Avenue W, Waterloo, Ont, Canada N2L 3G1
Nutr Neurosci 7:141-50. 2004..Trends in corticosterone measurements suggested higher stress reactivity in the LP group. These results do not provide strong support for the prenatal low protein model of hypertension and a relation with dietary DHA...
- Prenatal exposure to a maternal low-protein diet programmes a preference for high-fat foods in the young adult ratLeanne Bellinger
Centre for Reproduction and Early Life, School of Biosciences, University of Nottingham, Sutton Bonington, Loughborough LE12 5RD, UK
Br J Nutr 92:513-20. 2004..Maternal nutrition may thus promote changes in systems that are involved in control of appetite or the perception of palatability...
- Dietary protein restriction of pregnant rats induces and folic acid supplementation prevents epigenetic modification of hepatic gene expression in the offspringKaren A Lillycrop
Development and Cell Biology, University of Southampton, UK
J Nutr 135:1382-6. 2005..Epigenetic regulation of gene transcription provides a strong candidate mechanism for fetal programming...
- Maternal low-protein diet in rat pregnancy programs blood pressure through sex-specific mechanismsSarah McMullen
Centre for Reproduction and Early Life, Division of Nutritional Biochemistry, University of Nottingham, Sutton Bonington Campus, Loughborough LE12 5RD, UK
Am J Physiol Regul Integr Comp Physiol 288:R85-90. 2005....
- Microvascular rarefaction and decreased angiogenesis in rats with fetal programming of hypertension associated with exposure to a low-protein diet in uteroP Pladys
Research Center, Hopital Sainte Justine, Dept of Pediatrics, Univ of Montreal, Montreal, Quebec, Canada
Am J Physiol Regul Integr Comp Physiol 289:R1580-8. 2005..The study suggests that intrauterine protein restriction increases susceptibility to postnatal factors resulting in microvascular rarefaction, which could represent a primary event in the genesis of hypertension...
- Sex-specific effects of prenatal low-protein and carbenoxolone exposure on renal angiotensin receptor expression in ratsSarah McMullen
Division of Nutritional Sciences, University of Nottingham, Loughborough, LE12 5RD, United Kingdom
Hypertension 46:1374-80. 2005..Despite being targeted to the postnephrogenic period, inhibition of type 1 angiotensin receptor had an inhibitory effect on renal and somatic growth, additionally indicating its unsuitability during early life...
- A low maternal protein diet during pregnancy and lactation has sex- and window of exposure-specific effects on offspring growth and food intake, glucose metabolism and serum leptin in the ratE Zambrano
Department of Reproductive Biology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Vasco de Quiroga 15, 14000, Mexico, D F Mexico
J Physiol 571:221-30. 2006....
- The effect of intrauterine environment and low glomerular number on the histological changes in diabetic glomerulosclerosisS E Jones
Diabetes Research Group, School of Clinical Medical Sciences, University of Newcastle upon Tyne, Newcastle upon Tyne, UK
Diabetologia 49:191-9. 2006..We tested the hypothesis that diabetic glomerulosclerosis would develop more rapidly in animals with fewer glomeruli...
- Exposure to undernutrition in fetal life determines fat distribution, locomotor activity and food intake in ageing ratsL Bellinger
School of Biosciences, University of Nottingham, Sutton Bonington, Loughborough, UK
Int J Obes (Lond) 30:729-38. 2006..To assess the long-term impact of undernutrition during specific periods of fetal life, upon central adiposity, control of feeding behaviour and locomotor activity...
- Effect of maternal protein restriction in rats on cardiac fibrosis and capillarization in adulthoodKyungjoon Lim
Department of Anatomy and Cell Biology, Monash University, Clayton, Victoria, Australia
Pediatr Res 60:83-7. 2006....
- Adaptation to low-protein diet increases inhibition of gastric emptying by CCKVeronique Leray
Centre de Recherche en Nutrition Humaine, INSERM U539, Hotel Dieu, 44093 Nantes, France
Peptides 24:1929-34. 2003..Our data suggest that modulation of gastric emptying after adaptation to a low-protein diet involves up-regulation of both CCK-A receptors and CCK-induced contraction of antral smooth muscle...
- Maternal undernutrition reduces aortic wall thickness and elastin content in offspring rats without altering endothelial functionMichael R Skilton
Department of Medicine, University of Sydney, Sydney, NSW 2006, Australia
Clin Sci (Lond) 111:281-7. 2006..These changes in vascular structure may amplify aging-related changes to the vasculature and contribute to the pathophysiology of the putative link between impaired fetal growth and adult cardiovascular disease...
- Maternal gestational protein-calorie restriction decreases the number of glomeruli and causes glomerular hypertrophy in adult hypertensive ratsJorge R Almeida
Laboratory of Morphometry and Cardiovascular Morphology, Biomedical Center, Institute of Biology, State University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil
Am J Obstet Gynecol 192:945-51. 2005..This work analyzed the renal function and structure in offspring rats that were submitted to maternal protein-calorie restriction during prenatal or lactation periods...
- Modulation of rat liver cytochrome P450 by protein restriction assessed by biochemical and bacterial mutagenicity methods [corrected]L Cancino-Badías
CIBIOMED, ICBP Victoria de Girón, Ciudad Habana, Cuba
Mutagenesis 18:95-100. 2003..However, the mutagenic potency of benzo[a]pyrene was the same (4 revertants/ microg) with S9 derived from rats fed either a 6 or 24% protein diet...
- Intrauterine programming of bone. Part 2: alteration of skeletal structureS A Lanham
Bone and Joint Research Group, Developmental Origins of Health and Disease, University of Southampton, Southampton, SO16 6YD, UK
Osteoporos Int 19:157-67. 2008..Rat dams were given a low protein diet during pregnancy, and offspring were studied at different ages. Old aged rats showed site-specific strength differences. In utero nutrition has consequences in later life...
- Retinoic acid enhances nephron endowment in rats exposed to maternal protein restrictionJohn Makrakis
Department of Anatomy and Cell Biology, Monash University, Post Office Box 13C, Melbourne, VIC 3800, Australia
Pediatr Nephrol 22:1861-7. 2007..In conclusion, administration of a single bolus dose of retinoic acid during midgestation restored nephron endowment to normal in offspring exposed to maternal protein restriction...
- Intrauterine low protein diet increases fetal beta-cell sensitivity to NO and IL-1 beta: the protective role of taurineS Merezak
Laboratory of Cell Biology, World Health Organization Collaborating Center for the Biology of Development of the Endocrine Pancreas, , B-1348 Louvain-la-Neuve, Belgium
J Endocrinol 171:299-308. 2001..However, through in vitro and in vivo experiments our studies indicate that such effects can be rescued using amino acids such as taurine...
- Rapid neonatal weight gain in rats results in a renal ubiquinone (CoQ) deficiency associated with premature deathPiran Shelley
Neurochemistry Division, Institute of Neurology, UCL, London WC1N 3BG, UK
Mech Ageing Dev 128:681-7. 2007....
- Effects of rosiglitazone (a peroxysome proliferator-activated receptor gamma agonist) on the blood pressure and aortic structure in metabolically programmed (perinatal low protein) ratsThiago da Silva Torres
Laboratory of Morphometry and Cardiovascular Morphology, Biomedical Center, Institute of Biology, State University of Rio de Janeiro, Rio de Janeiro, Brazil
Hypertens Res 31:965-75. 2008..00001 for TS, two-way ANOVA). We conclude that rosiglitazone has beneficial effects in reducing the BP and the aortic tunica media hypertrophy with consequent balance of the wall stress in metabolically programmed offspring...
- Inadequate energy and excess protein intakes may be associated with worsening renal function in chronic kidney diseaseMeng Chuan Huang
Department of Nutrition, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
J Ren Nutr 18:187-94. 2008..Dietary energy and protein play important roles in chronic kidney disease (CKD). This study investigates the relationship between energy/protein intake status and renal function in CKD...
- Effect of protein-energy malnutrition in early life on the dimensions and bone quality of the adult rat mandibleRosa M Alippi
Department of Physiology, Faculty of Odontology, University of Buenos Aires, Marcelo T de Alvear 2142, 1122, Buenos Aires, Argentina
Arch Oral Biol 47:47-53. 2002....
- Maternal low-protein diet affects bone mass and mineral metabolism in suckling ratsH Fetoui
Animal Physiology Laboratory, Sciences Faculty of Sfax, Sfax, Tunisia
J Anim Physiol Anim Nutr (Berl) 92:448-55. 2008..These results showed that protein-restricted diet given to mothers during late pregnancy and early post-natal periods induced changes in body weight, skeletal growth and bone metabolism in their offspring...
- Nitrogen excretion in rats on a protein-free diet and during starvationAndre Chwalibog
Department of Basic Animal and Veterinary Sciences, University of Copenhagen, Denmark
Arch Anim Nutr 62:82-5. 2008..Consequently, the impact of former protein supply on N losses during starvation ought to be considered when evaluating minimum N requirement necessary to sustain life...
- Effects of a maternal low protein isocaloric diet on milk leptin and progeny serum leptin concentration and appetitive behavior in the first 21 days of neonatal life in the ratClaudia J Bautista
Department of Reproductive Biology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico, 14000, Mexico
Pediatr Res 63:358-63. 2008..These data suggest that fetal nutrition modifies timing of neonatal leptin surge and may contribute to the development of altered appetite and metabolic disorders in later life...
- Intrauterine programming of bone. Part 1: alteration of the osteogenic environmentS A Lanham
Bone and Joint Research Group, Developmental Origins of Health and Disease, University of Southampton, Southampton, SO16 6YD, UK
Osteoporos Int 19:147-56. 2008..Rat dams were given a low protein diet during pregnancy and 135 offspring studied at different ages. Bone biochemistry showed altered characteristics. Altered in utero diet has consequences for later life...
- The effect of a low-protein diet in pregnancy on offspring renal calcium handlingNick Ashton
Faculty of Life Sciences, University of Manchester, 1 124 Stopford Bldg, Oxford Road, Manchester M13 9PT, UK
Am J Physiol Regul Integr Comp Physiol 293:R759-65. 2007..This may contribute to the reduction in bone mass observed in this model...
- Hepatic structural alteration in adult programmed offspring (severe maternal protein restriction) is aggravated by post-weaning high-fat dietVanessa Souza-Mello
Laboratory of Morphometry and Cardiovascular Morphology, Biomedical Center, Institute of Biology, State University of Rio de Janeiro, Av 28 de setembro 87 fds, 20551 030 Rio de Janeiro, RJ, Brazil
Br J Nutr 98:1159-69. 2007..All of these serve to highlight the paramount importance of intra-uterine conditions and postnatal diet quality when it comes to the pathogenesis of chronic diseases...
- Increased systolic blood pressure in rats induced by a maternal low-protein diet is reversed by dietary supplementation with glycineAlan A Jackson
Institute of Human Nutrition, Fetal Origins of Adult Disease Research Division, University of Southampton, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK
Clin Sci (Lond) 103:633-9. 2002..The availability of glycine appears to be of critical importance for normal cardiovascular development...
- Induction of altered epigenetic regulation of the hepatic glucocorticoid receptor in the offspring of rats fed a protein-restricted diet during pregnancy suggests that reduced DNA methyltransferase-1 expression is involved in impaired DNA methylation and Karen A Lillycrop
Development and Cell Biology, Biomedical Sciences Building, University of Southampton, Bassett Crescent East, Southampton SO16 7PX, UK
Br J Nutr 97:1064-73. 2007..These findings suggest that induction in the offspring of altered epigenetic regulation of the hepatic GR1(10) promoter, and hence metabolic phenotype, may be due to reduced Dnmt1 expression...
- Prenatal exposure to undernutrition and programming of responses to high-fat feeding in the ratAml Erhuma
School of Biomedical Sciences, University of Nottingham, Queens Medical Centre, Nottingham NG7 2UH, UK
Br J Nutr 98:517-24. 2007..This study further establishes a role for prenatal nutrition in programming the genes involved in lipid metabolism and appetite regulation...
- Nutritional recovery with a soybean flour diet improves the insulin response to a glucose load without modifying glucose homeostasisElisângela de Arruda Oliveira
Secretaria de Estado de Saúde, Cuiaba, Mato Grasso, Brazil
Nutrition 24:76-83. 2008....
- Fetal exposure to a maternal low-protein diet is associated with altered left ventricular pressure response to ischaemia-reperfusion injuryMatthew J Elmes
Division of Nutritional Sciences, University of Nottingham, Sutton Bonington Campus, Loughborough, Leicestershire, UK
Br J Nutr 98:93-100. 2007..Undernutrition during development may increase susceptibility to CHD by impairing recovery from coronary events...
- Depot-specific effects of early growth retardation on adipocyte insulin actionS E Ozanne
Department of Clinical Biochemistry, University of Cambridge, UK
Horm Metab Res 32:71-5. 2000..These results suggest that certain changes associated with early growth retardation are depot-specific, being enhanced in the more metabolically active intra-abdominal and epididymal tissues...
- Serum leptin and insulin levels in lactating protein-restricted rats: implications for energy balanceC L P Ferreira
Departmento de Alimentos e Nutricao, Universidade Fedral de Mato Grosso, Cuiaba, Brazil
Br J Nutr 97:27-34. 2007..This metabolic adaptation was obtained, at least in part, by hypoinsulinaemia that resulted in increased insulin sensitivity favouring enhanced fat deposition, hyperleptinaemia and hypophagia...
- Effects of pre- and postnatal protein deprivation on atrial natriuretic peptide- (ANP-) granules of the right auricular cardiocytes. An ultrastructural morphometric studyEliane Florencio Gama
Dept of Anatomy, Sao Judas Tadeu University, Sao Paulo, SP, Brasil
Eur J Nutr 46:245-50. 2007..The atrial natriuretic peptide (ANP) is a peptide hormone that is mainly produced in the cardiocytes of the atria and auricles, where it is stored within secretory granules...
- Management of refractory hepatic encephalopathy after insertion of TIPS: long-term results of shunt reduction with hourglass-shaped balloon-expandable stent-graftFabrizio Fanelli
Vascular and Interventional Radiology Unit, Department of Radiological Sciences, Sapienza University of Rome, Viale Regina Elena, 324 00161 Rome, Italy
AJR Am J Roentgenol 193:1696-702. 2009....
- Prenatal diagnosis for arginase deficiency: a case studyS Hewson
Division of Clinical and Metabolic Genetics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
J Inherit Metab Dis 26:607-10. 2003..The result was confirmed by postnatal enzyme analysis of red cells from the newborn. On the basis of our experience, prenatal diagnosis of arginase deficiency by cord red blood cell arginase activity assay appears possible...
- Long-term outcome of patients with argininosuccinate lyase deficiency diagnosed by newborn screening in AustriaS Mercimek-Mahmutoglu
Department of Pediatrics, Division of Biochemical Diseases, British Columbia University, Vancouver, BC, Canada
Mol Genet Metab 100:24-8. 2010..Patients were treated with protein restricted diet and oral arginine supplementation during infancy and childhood...
- TIPS-related hepatic encephalopathy: management options with novel endovascular techniquesDavid C Madoff
Division of Diagnostic Imaging, Section of Vascular and Interventional Radiology, University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Unit 325, Houston, TX 77030 4009, USA
Radiographics 24:21-36; discussion 36-7. 2004..Further research is necessary to improve our understanding of TIPS-related hepatic encephalopathy so that newer, less invasive and safer procedures can be developed to treat this difficult clinical problem...
- Skeletal muscle and nutritional assessment in chronic renal failure patients on a protein-restricted dietA Cupisti
Department of Internal Medicine, Nephrology Unit, University of Pisa, Pisa, Italy
J Intern Med 255:115-24. 2004..The close relationship between protein-energy malnutrition and quality of life, morbidity and mortality, makes mandatory a careful evaluation of the nutritional status and muscle mass in chronic renal failure (CRF) patients...
- Pharmacokinetics of sapropterin in patients with phenylketonuriaFrancois Feillet
Centre de Référence des Maladies Héréditaires du Métabolisme, Hôpital d Enfants, CHU Brabois, Vandoeuvre les Nancy, France
Clin Pharmacokinet 47:817-25. 2008..The objective of the current study was to characterize the pharmacokinetics and pharmacokinetic variability of sapropterin and to identify the characteristics that influence this variability...
- Kidney transplantation in a girl with methylmalonic acidemia and end stage renal failureR Lubrano
Istituto di Clinica Pediatrica, Policlinico Umberto I, Universita degli Studi di Roma La Sapienza, Viale Regina Elena 324, 00161 Rome, Italy
Pediatr Nephrol 16:848-51. 2001..Otherwise, the therapeutic goal can be achieved with a protein-restricted diet...
- Maternal malnutrition during lactation alters the folliculogenesis and gonadotropins and estrogen isoforms ovarian receptors in the offspring at pubertyTatiane da Silva Faria
Urogenital Research Unit UERJ, State University of Rio de Janeiro, Avenue 28 de Setembro, Rio de Janeiro, RJ, Brazil
J Endocrinol 198:625-34. 2008....
- Mammary sensitivity to protein restriction and re-alimentationM G Goodwill
Institute of Ecology and Resource Management, University of Edinburgh
Br J Nutr 76:423-34. 1996..These results show that rats offered a protein-restricted diet during lactation suffer mammary underdevelopment, but this may be rapidly reversed by re-alimentation with a high-protein diet...
- Cross-sectional multicenter study of patients with urea cycle disorders in the United StatesMendel Tuchman
Children s National Medical Center, The George Washington University, School of Medicine, 111 Michigan Avenue, N W, Washington, DC 20010, USA
Mol Genet Metab 94:397-402. 2008..Sixty-three percent were on a protein restricted diet, 37% were on Na-phenylbutyrate and 5% were on Na-benzoate...
- Progressive liver fibrosis in late-onset argininosuccinate lyase deficiencyToshihiko Mori
Department of Pediatrics, Otaru Kyokai Hospital, 1 6 15 Suminoe, Otaru, Hokkaido 047 8510, Japan
Pediatr Dev Pathol 5:597-601. 2002..boy, with late-onset argininosuccinate lyase (ASL) deficiency with hepatomegaly, was treated by protein restricted diet and arginine supplementation; he was followed for 3 years...
- Effect of nickel sulfate on testicular steroidogenesis in rats during protein restrictionKusal K Das
Department of Physiology, Al Ameen Medical College, Bijapur, Karnataka, India
Environ Health Perspect 110:923-6. 2002..However, these alterations were reversible in both groups of animals fed normal protein diets and protein-restricted diets...
- Outpatient treatment of propionic acidemia-associated hyperammonemia with N-carbamoyl-L-glutamate in an infantErdogan Soyucen
Cerrahpasa Medical Faculty, Department of Pediatrics, Istanbul University, Istanbul, Turkey
Clin Ther 32:710-3. 2010..The aim of this research letter was to describe the use of N-carbamoyl-L-glutamate as first-line treatment of hyperammonemia in a 4-month-old female patient with propionic acidemia (PA)...
- Effect of combined treatment of oral sorbent with protein-restricted diet on change of reciprocal creatinine slope in patients with CRFTsutomu Sanaka
Department of Nephrology and Blood Purification, Daini Hospital Medical Center, Tokyo Women s Medical University, Tokyo 116 8567, Japan
Am J Kidney Dis 41:S35-7. 2003..Based on the different mechanisms of reducing indoxyl sulfate levels, the addition of AST-120 to an LPD was investigated...
- Consanguineous 3-methylcrotonyl-CoA carboxylase deficiency: early-onset necrotizing encephalopathy with lethal outcomeT Baykal
Department Nutrition and Metabolism, Children s Hospital, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey
J Inherit Metab Dis 28:229-33. 2005..Mutation analysis revealed a homozygous mutation in the splice acceptor site of intron 15 in the MCC beta-subunit. Early-onset severe necrotizing encephalopathy should be included in the differential diagnosis of isolated MCC deficiency...
- Development of beta-cell mass in fetuses of rats deprived of protein and/or energy in last trimester of pregnancyEric Bertin
Laboratoire de Physiopathologie de la Nutrition, Centre National de la Recherche Scientifique UMR 7059, Université Paris 7 D Diderot, 75251 Paris Cedex 05, France
Am J Physiol Regul Integr Comp Physiol 283:R623-30. 2002..Moreover, our results support the hypothesis that taurine might play an important role in fetal beta-cell mass function...
- Evidence that DNA damage is associated to phenylalanine blood levels in leukocytes from phenylketonuric patientsAngela Sitta
Programa de Pós Graduação em Ciências Biológicas, Bioquimica, UFRGS, Rua Ramiro Barcelos, 2600, CEP 90035 003, Porto Alegre, RS, Brazil
Mutat Res 679:13-6. 2009..Treatment for PKU consists of a protein restricted diet supplemented with a mixture containing essential amino acids (other than Phe) and micronutrients...
- Effect of food manipulation on the neuropeptide Y neuronal system in the diencephalon of ewesJ Polkowska
The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, 05 110, Jablonna, Poland
J Chem Neuroanat 21:149-59. 2001..Long-term feeding the protein restricted diet caused a prominent expression of the immunoreactive material solely in the hypothalamic NPY neurones, ..
- Isovaleric acidemia: new aspects of genetic and phenotypic heterogeneityJerry Vockley
Department of Pediatrics, University of Pittsburgh School of Medicine, Children s Hospital of Pittsburgh, 3705 Fifth Avenue, Pittsburgh, PA 15238, USA
Am J Med Genet C Semin Med Genet 142:95-103. 2006..Early diagnosis and treatment with a protein restricted diet and supplementation with carnitine and glycine are effective in promoting normal development in severely ..
- Effect of short- and long-term exposition to high phenylalanine blood levels on oxidative damage in phenylketonuric patientsAngela Sitta
Servico de Genetica Medica, HCPA, Porto Alegre, RS, Brazil
Int J Dev Neurosci 27:243-7. 2009..phenylalanine levels on oxidative stress parameters in phenylketonuric patients who did not adhere to protein restricted diet. We evaluated a large spectrum of oxidative stress parameters in plasma and erythrocytes from ..
- The relationship of plasma glutamine to ammonium and of glycine to acid-base balance in propionic acidaemiaZ N Al-Hassnan
Department of Medical Genetics, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
J Inherit Metab Dis 26:89-91. 2003..The association of high plasma glycine with good acid-base balance might have a potential role in management and warrants further investigation...
- Malnutrition during lactation changes growth hormone mRNA expression in offspring at weaning and in adulthoodEgberto Gaspar de Moura
Departamento de Ciencias Fisiologicas, Instituto de Biologia Roberto Alcantara Gomes, Universidade do Estado do Rio de Janeiro, Rio de Janeiro 20551 030, Brazil
J Nutr Biochem 18:134-9. 2007..We suggest that malnutrition during lactation may program GH mRNA expression patterns in adulthood and that these changes could be responsible for differences in growth patterns...
- The prostate of weaned pups is altered by maternal malnutrition during lactation in ratsCristiane da F Ramos
State University of Rio de Janeiro, UERJ, Brazil
Asian J Androl 12:180-5. 2010..09 +/- 0.01, PER = 0.44 +/- 0.04, ER = 0.15 +/- 0.03 ng mL(-1), P < 0.001). An adequate nutritional state in early life is important for normal growth of the prostate gland, which seem to be related to serum levels of estradiol...
- Long-chain polyunsaturated fatty acid status in phenylketonuric patients treated with tetrahydrobiopterinMaria A Vilaseca
Department of Biochemistry, Barcelona, Spain
Clin Biochem 43:411-5. 2010..To evaluate LCPUFA composition in PKU patients treated with BH(4)...
- Long-term effects of malnutrition during lactation on the thyroid function of offspringM C Passos
Department of Applied Nutrition, Nutrition Institute, State University of Rio de Janeiro, Av 28 de Setembro, 87, Rio de Janeiro, RJ 20550 030, Brazil
Horm Metab Res 34:40-3. 2002..Probably, PR group had a high thyroid function, whereas the ER group only had an increase in the deiodination of T4. The hyperthyroidism in the PR group could explain the low body weight observed in those animals...
- Increased circulating concentrations of parathyroid hormone in healthy, young women consuming a protein-restricted dietJ E Kerstetter
School of Allied Health, University of Connecticut, Storrs 06269 2101, USA
Am J Clin Nutr 66:1188-96. 1997..Further study is needed to both clarify the mechanisms by which these changes are induced and to better define the amount of dietary protein that will optimize skeletal health in young women...
- Metabolic programming of ovarian angiogenesis and folliculogenesis by maternal malnutrition during lactationRafaela Veiga Ferreira
Urogenital Research Unit, State University of Rio de Janeiro, Rio de Janeiro, Brazil
Fertil Steril 93:2572-80. 2010..To evaluate whether maternal malnutrition during lactation programs ovarian folliculogenesis and the expression of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) and its receptors KDR, Flt-1, and FGFR...
- Prevention by L-carnitine of DNA damage induced by propionic and L-methylmalonic acids in human peripheral leukocytes in vitroGraziela S Ribas
Programa de Pós Graduação em Ciências Farmacêuticas, UFRGS, Av Ipiranga 2752, Porto Alegre, RS, Brazil
Mutat Res 702:123-8. 2010..l-Carnitine significantly reduced PA- and MMA-induced DNA damage, in a concentration-dependent manner. Our findings indicate that PA and MMA induce DNA damage and l-carnitine is able to prevent this damage...
- Protective role of curcumin against nicotine-induced genotoxicity on rat liver under restricted dietary proteinGargi Bandyopadhyaya
Department of Physics, Jadavpur University, Raja S C Moullick Road, Kolkata 700 032, India
Eur J Pharmacol 588:151-7. 2008..Highly significant (P<0.001) DNA damages (37% in normal diet and 56% in protein restricted diet) of the liver tissues were observed due to nicotine treatment...
- Expression of agouti-related peptide, neuropeptide Y, pro-opiomelanocortin and the leptin receptor isoforms in fetal mouse brain from pregnant dams on a protein-restricted dietPaul L Terroni
Centre for Developmental Origins of Health and Disease, University of Southampton, School of Medicine, Princess Anne Hospital, Level F mailpoint 887, Coxford Road, Southampton, UK
Brain Res Mol Brain Res 140:111-5. 2005..Levels of expression for these genes were altered in brains of E12 fetuses from pregnant dams on a protein-restricted diet, suggesting that the fetal brain is responsive to changes in maternal nutrition prior to birth...
- Wheat starch, gliadin, and the gluten-free dietT Thompson
J Am Diet Assoc 101:1456-9. 2001..Until this research is conducted, dietitians in the United States should continue to advise their patients against the use of wheat starch and other foods rendered gluten free...
- [Objectives of the low-protein diet]G Brunori
S C di Nefrologia, Ospedale Santa Chiara, Largo Medaglie D Oro 9, Trento, Italy
G Ital Nefrol 25:S14-7. 2008..The Number-to-Treat estimate in the Cochrane meta-analysis (NNT=16) was even better than similar estimates in the statin prevention trials ''4S'' and ''WOSCOPS''...
- Reduction of plasma asymmetric dimethylarginine in obese patients with chronic kidney disease after three years of a low-protein diet supplemented with keto-amino acids: a randomized controlled trialVladimir Teplan
Department of Nephrology, Transplant Center, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
Wien Klin Wochenschr 120:478-85. 2008..In this study we tested the hypothesis that elevated ADMA can be reduced in obese CKD patients by long-term administration of a low-protein diet supplemented with keto-amino acids...
- Intermittent hyperammonemic encephalopathy in a child with ornithine transcarbamylase deficiencySheffali Gulati
Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India
Indian J Pediatr 71:645-7. 2004..The authors report a heterozygous female with OTC deficiency who presented with recurrent encephalopathy...
- Three-year audit of the hyperphenylalaninaemia/phenylketonuria spectrum in VictoriaAvihu Boneh
Metabolic Service, Genetic Health Services Victoria, Royal Children s Hospital, Parkville, Vic, Australia
J Paediatr Child Health 42:496-8. 2006..To determine the prevalence, the types and severity of hyperphenylalaninaemia (including phenylketonuria (PKU)) in Victoria and to report on a new treatment modality of PKU...
- Taurine supplementation to a low protein diet during foetal and early postnatal life restores a normal proliferation and apoptosis of rat pancreatic isletsS Boujendar
Laboratory of Cellular Biology, World Health Collaborating Center for the Development of the Endocrine Pancreas, Catholic University of Louvain, Louvain la Neuve, Belgium
Diabetologia 45:856-66. 2002..In this study we aim to evaluate the role of taurine in the alterations observed in rats after a low protein diet...
- Investigation of glutaric acidemia type I.David Koeller; Fiscal Year: 2004..Alternatively, if it is determined that normalization of metabolite levels is insufficient to prevent neuropathology in GA-I, alternative approaches to therapy need to be developed. ..
- Renal and Hormonal Mechanisms of Perinatal ProgrammingLORI WOODS; Fiscal Year: 2005..Intrarenal RAS activity will be measured in fetal and newborn animals. Arterial pressure, renal function, and nephron number will be measured in chronically instrumented juvenile and adult offspring. ..
- Mechanisms of Sexual Dimorphism in Perinatal ProgrammingLORI WOODS; Fiscal Year: 2005..Renal renin-angiotensin system components will be measured in the neonatal period, and arterial pressure, renal function, and glomerular number and volume will be measured in juvenile and adult animals. ..
- GENETIC & ENVIRONMENTAL DETERMINANTS OF CRANIOFACIAL DISBrendan Lee; Fiscal Year: 2005..Together, these studies will identify genes important in pathogenesis of human malformation and elucidate their modes of action in both cell autonomous and cell non-autonomous models mechanisms of development. ..
- In vivo function and tolerance to Factor VIII variantsBRENDAN HL LEE; Fiscal Year: 2011..abstract_text> ..
- ENTERAL PRECURSORS FOR UREA SYNTHESIS IN HUMANSBrendan Lee; Fiscal Year: 2006..In addition it is anticipated that the results will benef it other individuals who have compromised protein metabolism. ..
- Society for Inherited Metabolic Disorders Annual MeetingGerard Vockley; Fiscal Year: 2005..NIH support of this application will greatly facilitate US investigators remaining in the forefront of this exciting and expanding field. ..
- Prenatal and Perinatal Programming of Adult HypertensionVESA VEHASKARI; Fiscal Year: 2006..The effect of short-term postnatal dietary and phamacological manipulations on the long-term blood pressure profile will be investigated. ..
- Initiation and Inhibition of Medial Artery CalcificationPaul Price; Fiscal Year: 2008..abstract_text> ..
- Cardiovascular Disease and Diabetic NephropathyRajnish Mehrotra; Fiscal Year: 2008..The applicant has institutional support and a career development plan including obtaining a Masters in Clinical Investigation, to achieve his career goals. ..
- Transcriptional Regulation of Craniofacial SkeletogenesisBrendan Lee; Fiscal Year: 2009....
- Dysregulation of 3-prolyl-hydroxylation in Human Skeletal DysplasiasBRENDAN HL LEE; Fiscal Year: 2010..e., the in vivo phenotypic and biochemical consequences of dysregulation of the 3-prolyl-hydroxylation machinery. ..
- The molecular bases of inherited urea cycle disorders and ureagenesis regulationMendel Tuchman; Fiscal Year: 2010....
- Clinical Phenotype of Imprinted Genes of Chromosome 14Vernon Sutton; Fiscal Year: 2005..This phenotype delineation will lay the foundation for understanding the effects and pathogenesis of imprinted genes on chromosome 14. ..
- Adenoviral hepatocyte gene therapy in CitrullinemiaBrendan Lee; Fiscal Year: 2005..The data from these studies would be widely applicable to gene replacement therapy in a host of intrinsic disorders of liver metabolism as well as deficiencies of secretory proteins. ..
- CNS Counterregulatory MechanismsLauren Jacobson; Fiscal Year: 2004..These studies will provide novel information on the neuropharmacology of glucose control that may reveal therapeutic strategies to prevent hypoglycemia unawareness. ..
- EFFECT OF POTASSIUM BICARBONATE ON BONE AND MUSCLEBess Dawson Hughes; Fiscal Year: 2008....
- Novel Cardiac Risk Factors & Endothelial Function in CKDVandana Menon; Fiscal Year: 2008..This award will provide Dr. Menon with the final training necessary for her to make the transition from trainee to principal investigator. ..
- "MENTORED PATIENT-ORIENTED RESEARCH CAREER DEVELOPMENT AWARD"Allon Friedman; Fiscal Year: 2009..abstract_text> ..
- Role of glucocorticoids in hypoglycemia unawarenessLauren Jacobson; Fiscal Year: 2003..abstract_text> ..
- TRANSCRIPTIONAL REGULATORS IN CHONDROGENESISBrendan Lee; Fiscal Year: 2002....
- MOLECULAR CHARACTERIZATION OF ACYL-COA DEHYDROGENASESGerard Vockley; Fiscal Year: 2004..This work will lead to a more complete understanding of the ACD gene family, and ultimately, to an improved ability to diagnose and treat patients with deficiencies of these enzymes. ..
- Resistance Training during Maintenance DialysisCARMEN SCEPPA; Fiscal Year: 2004..By implementing such intervention, we hope to offer a therapeutic strategy that can be incorporated to the standard of care of ESRD patients by working in conjunction with the dialysis unit staff. ..
- Mitochondrial Function and mtDNA Deletions in SarcopeniaDominic Raj; Fiscal Year: 2005..abstract_text> ..
- Programming of gene expression during fetal lifeS Ozanne; Fiscal Year: 2005....
- MECHANISMS OF PROTEIN ACCUMULATION IN RENAL HYPERTROPHYHarold Franch; Fiscal Year: 2002..It should also lay the ground work for further investigations into the mechanisms behind renal hypertrophy. ..
- MATRIX GLA PROTEIN AND CARTILAGE CALCIFICATIONPaul Price; Fiscal Year: 2001..The investigators will further study the demonstrated ability of MGP to inhibit calcification in supersaturated solutions, and will investigate the ability of MGP to inhibit matrix vesicle -initiated calcification. ..
- DIETARY SOY SUPPLEMENTS: CARDIOPROTECTIVE MECHANISMSMichael Adams; Fiscal Year: 2008....
- NIH OSTEOPOROSIS & RELATED BONE DISEASES RESOURCE CENTERBess Dawson Hughes; Fiscal Year: 2002..Specific efforts include supporting the National Osteoporosis Data Group, collecting and disseminating definitive statistics on bone diseases and on conditions co-morbid with osteoporosis, and preparing summary reports. ..
- Genetics of Congenital Left-sided Heart DefectsKim McBride; Fiscal Year: 2007..The proposed studies will launch the applicant on an independent research career, providing a base on which to advance genetic analyses of CCVM with the aim to reduce their occurrence and provide new treatment opportunities. ..
- Is Tissue ACE Required for Diabetic Renal Damage?Harold Franch; Fiscal Year: 2005..We believe that this approach will not only critically test our hypothesis, but will also lay the ground work for future studies into the role of ACE in the diabetic kidney. ..
- Phenylalanine Hydroxylase Deficiency: Response to BH4Reuben Matalon; Fiscal Year: 2002..Treatment with BH4 should lead to a better outcome for PKU patients and for maternal PKU. ..
- KNOCKOUT MODEL FOR CANAVAN DISEASEReuben Matalon; Fiscal Year: 2001..5) The knock-out mouse will be used in future studies for determining the metabolic role of NAA in brain, for experimentation with enzyme therapy and gene therapy. ..
- DIETARY ADHERENCE IN CHILDREN WITH CHRONIC CONDITIONSCAROLYN IEVERS LANDIS; Fiscal Year: 2005..Study 2 is a pilot study to develop and evaluate family-based intervention programs to improve dietary adherence for children in the target populations. ..
- RESPONSE OF PHENYLKETONURIA TO TETRAHYDROBIOPTERIN (BH4)Reuben Matalon; Fiscal Year: 2007..Abstract Not Provided ..