caloric restriction

Summary

Summary: Reduction in caloric intake without reduction in adequate nutrition. In experimental animals, caloric restriction has been shown to extend lifespan and enhance other physiological variables.

Top Publications

  1. pmc Caloric restriction delays disease onset and mortality in rhesus monkeys
    Ricki J Colman
    Wisconsin National Primate Research Center, University of Wisconsin, Madison, WI 53715, USA
    Science 325:201-4. 2009
  2. pmc Sirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restriction
    Shinichi Someya
    Departments of Genetics and Medical Genetics, University of Wisconsin, Madison, 53706, USA
    Cell 143:802-12. 2010
  3. pmc Extending healthy life span--from yeast to humans
    Luigi Fontana
    Division of Geriatrics and Nutritional Science, Washington University School of Medicine, St Louis, MO 63110, USA
    Science 328:321-6. 2010
  4. ncbi Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
    Konrad T Howitz
    BIOMOL Research Laboratories, Inc, 5120 Butler Pike, Plymouth Meeting, Pennsylvania 19462, USA
    Nature 425:191-6. 2003
  5. pmc Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study
    Julie A Mattison
    Laboratory of Experimental Gerontology, National Institute on Aging, NIH Animal Center, Dickerson, Maryland 20842, USA
    Nature 489:318-21. 2012
  6. ncbi Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1
    Joseph T Rodgers
    Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nature 434:113-8. 2005
  7. pmc Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila
    Camilla Burnett
    Institute of Healthy Ageing and Department of Genetics, Evolution and Environment, University College London, Gower Street, London WC1E 6BT, UK
    Nature 477:482-5. 2011
  8. ncbi Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activation
    Xiaolei Qiu
    Department of Nutritional Science and Toxicology, University of California, Berkeley, CA 94720, USA
    Cell Metab 12:662-7. 2010
  9. ncbi Calorie restriction promotes mitochondrial biogenesis by inducing the expression of eNOS
    Enzo Nisoli
    Integrated Laboratories Network, Department of Preclinical Sciences, Luigi Sacco Hospital, Milan University, 20157 Milan, Italy
    Science 310:314-7. 2005
  10. ncbi SIRT1 transgenic mice show phenotypes resembling calorie restriction
    Laura Bordone
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Aging Cell 6:759-67. 2007

Detail Information

Publications368 found, 100 shown here

  1. pmc Caloric restriction delays disease onset and mortality in rhesus monkeys
    Ricki J Colman
    Wisconsin National Primate Research Center, University of Wisconsin, Madison, WI 53715, USA
    Science 325:201-4. 2009
    b>Caloric restriction (CR), without malnutrition, delays aging and extends life span in diverse species; however, its effect on resistance to illness and mortality in primates has not been clearly established...
  2. pmc Sirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restriction
    Shinichi Someya
    Departments of Genetics and Medical Genetics, University of Wisconsin, Madison, 53706, USA
    Cell 143:802-12. 2010
    b>Caloric restriction (CR) extends the life span and health span of a variety of species and slows the progression of age-related hearing loss (AHL), a common age-related disorder associated with oxidative stress...
  3. pmc Extending healthy life span--from yeast to humans
    Luigi Fontana
    Division of Geriatrics and Nutritional Science, Washington University School of Medicine, St Louis, MO 63110, USA
    Science 328:321-6. 2010
    ..We discuss these findings and their potential application to prevention of age-related disease and promotion of healthy aging in humans, and the challenge of possible negative side effects...
  4. ncbi Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
    Konrad T Howitz
    BIOMOL Research Laboratories, Inc, 5120 Butler Pike, Plymouth Meeting, Pennsylvania 19462, USA
    Nature 425:191-6. 2003
    ..We discuss possible evolutionary origins of this phenomenon and suggest new lines of research into the therapeutic use of sirtuin activators...
  5. pmc Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study
    Julie A Mattison
    Laboratory of Experimental Gerontology, National Institute on Aging, NIH Animal Center, Dickerson, Maryland 20842, USA
    Nature 489:318-21. 2012
    ....
  6. ncbi Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1
    Joseph T Rodgers
    Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nature 434:113-8. 2005
    ..b>Caloric restriction causes many changes in glucose metabolism and extends lifespan; however, how this metabolism is connected ..
  7. pmc Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila
    Camilla Burnett
    Institute of Healthy Ageing and Department of Genetics, Evolution and Environment, University College London, Gower Street, London WC1E 6BT, UK
    Nature 477:482-5. 2011
    ..Our findings do not rule out a role for sirtuins in determination of metazoan lifespan, but they do cast doubt on the robustness of the previously reported effects of sirtuins on lifespan in C. elegans and Drosophila...
  8. ncbi Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activation
    Xiaolei Qiu
    Department of Nutritional Science and Toxicology, University of California, Berkeley, CA 94720, USA
    Cell Metab 12:662-7. 2010
    ..Our studies identify a defense program that CR provokes to reduce oxidative stress and suggest approaches to combat aging and oxidative stress-related diseases...
  9. ncbi Calorie restriction promotes mitochondrial biogenesis by inducing the expression of eNOS
    Enzo Nisoli
    Integrated Laboratories Network, Department of Preclinical Sciences, Luigi Sacco Hospital, Milan University, 20157 Milan, Italy
    Science 310:314-7. 2005
    ..These effects were strongly attenuated in eNOS null-mutant mice. Thus, nitric oxide plays a fundamental role in the processes induced by calorie restriction and may be involved in the extension of life span in mammals...
  10. ncbi SIRT1 transgenic mice show phenotypes resembling calorie restriction
    Laura Bordone
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Aging Cell 6:759-67. 2007
    ..Our findings suggest that increased expression of SIRT1 in mice elicits beneficial phenotypes that may be relevant to human health and longevity...
  11. ncbi Calorie restriction: decelerating mTOR-driven aging from cells to organisms (including humans)
    Mikhail V Blagosklonny
    Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY, USA
    Cell Cycle 9:683-8. 2010
    ..Therefore in humans the effect of CR may be somewhat blunted. Still how much does CR extend human lifespan? And could this extension be surpassed by gerosuppressants such as rapamycin?..
  12. ncbi The endocrine regulation of aging by insulin-like signals
    Marc Tatar
    Department of Ecology and Evolutionary Biology, Brown University, Providence, RI 02912, USA
    Science 299:1346-51. 2003
    ....
  13. ncbi Caloric restriction
    John R Speakman
    Institute of Biological and Environmental Sciences, University of Aberdeen, Aberdeen, Scotland, UK
    Mol Aspects Med 32:159-221. 2011
    ..Lifelong caloric restriction (CR) may extend life by up to 50% in rodents, with progressively less impact the later in life it is ..
  14. pmc Ink4a/Arf expression is a biomarker of aging
    Janakiraman Krishnamurthy
    Department of Medicine, The Lineberger Comprehensive Cancer Center, The University of North Carolina School of Medicine, Chapel Hill, North Carolina, 27599 7295, USA
    J Clin Invest 114:1299-307. 2004
    ..age-associated increase in expression of p16INK4a and Arf is attenuated in the kidney, ovary, and heart by caloric restriction, and this decrease correlates with diminished expression of an in vivo marker of senescence, as well as ..
  15. ncbi Extended longevity in mice lacking the insulin receptor in adipose tissue
    Matthias Bluher
    Joslin Diabetes Center and Department of Medicine, Harvard Medical School, One Joslin Place, Boston, MA, 02215 USA
    Science 299:572-4. 2003
    b>Caloric restriction has been shown to increase longevity in organisms ranging from yeast to mammals...
  16. pmc Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span
    Kevin J Pearson
    Laboratory of Experimental Gerontology, National Institute on Aging, National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Cell Metab 8:157-68. 2008
    ..Our findings indicate that resveratrol treatment has a range of beneficial effects in mice but does not increase the longevity of ad libitum-fed animals when started midlife...
  17. ncbi SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells
    Marcia C Haigis
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA
    Cell 126:941-54. 2006
    ..These results indicate that SIRT4 functions in beta cell mitochondria to repress the activity of GDH by ADP-ribosylation, thereby downregulating insulin secretion in response to amino acids, effects that are alleviated during CR...
  18. pmc Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes
    Jill C Milne
    Sirtris Pharmaceuticals Inc, 790 Memorial Drive, Cambridge, Massachusetts 02139, USA
    Nature 450:712-6. 2007
    ..Thus, SIRT1 activation is a promising new therapeutic approach for treating diseases of ageing such as type 2 diabetes...
  19. ncbi Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase
    Haim Y Cohen
    Department of Pathology, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Science 305:390-2. 2004
    A major cause of aging is thought to result from the cumulative effects of cell loss over time. In yeast, caloric restriction (CR) delays aging by activating the Sir2 deacetylase...
  20. ncbi Two neurons mediate diet-restriction-induced longevity in C. elegans
    Nicholas A Bishop
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Nature 447:545-9. 2007
    ....
  21. pmc Lifespan and reproduction in Drosophila: New insights from nutritional geometry
    Kwang Pum Lee
    School of Biological Sciences and Centre for Mathematical Biology, University of Sydney, Sydney NSW 2006, Australia
    Proc Natl Acad Sci U S A 105:2498-503. 2008
    ..b>Caloric restriction (CR) was not responsible for extending lifespan in our experimental flies...
  22. pmc Metformin induces a dietary restriction-like state and the oxidative stress response to extend C. elegans Healthspan via AMPK, LKB1, and SKN-1
    Brian Onken
    Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, New Jersey, United States of America
    PLoS ONE 5:e8758. 2010
    ..In addition to defining molecular players operative in metformin healthspan benefits, our data suggest that metformin may be a plausible pharmacological intervention to promote healthy human aging...
  23. ncbi Can autophagy promote longevity?
    Frank Madeo
    Institute of Molecular Biosciences, University of Graz, 8010 Graz, Austria
    Nat Cell Biol 12:842-6. 2010
    ..Longevity-promoting regimens, including caloric restriction and inhibition of TOR with rapamycin, resveratrol or the natural polyamine spermidine, have been associated ..
  24. ncbi Ribosomal protein S6 kinase 1 signaling regulates mammalian life span
    Colin Selman
    Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK
    Science 326:140-4. 2009
    b>Caloric restriction (CR) protects against aging and disease, but the mechanisms by which this affects mammalian life span are unclear...
  25. pmc 4E-BP extends lifespan upon dietary restriction by enhancing mitochondrial activity in Drosophila
    Brian M Zid
    California Institute of Technology, Pasadena, CA 91125, USA
    Cell 139:149-60. 2009
    ..For a video summary of this article, see the PaperFlick file with the Supplemental Data available online...
  26. pmc Long-term calorie restriction is highly effective in reducing the risk for atherosclerosis in humans
    Luigi Fontana
    Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 101:6659-63. 2004
    Little is known regarding the long-term effects of caloric restriction (CR) on the risk for atherosclerosis. We evaluated the effect of CR on risk factors for atherosclerosis in individuals who are restricting food intake to slow aging...
  27. pmc Effects of a caloric restriction weight loss diet and exercise on inflammatory biomarkers in overweight/obese postmenopausal women: a randomized controlled trial
    Ikuyo Imayama
    Epidemiology Program, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Cancer Res 72:2314-26. 2012
    ..We examined the effects of a caloric restriction weight loss diet and exercise on inflammatory biomarkers in 439 women...
  28. pmc A low dose of dietary resveratrol partially mimics caloric restriction and retards aging parameters in mice
    Jamie L Barger
    LifeGen Technologies, LLC, Madison, Wisconsin, United States of America
    PLoS ONE 3:e2264. 2008
    ..Resveratrol, at doses that can be readily achieved in humans, fulfills the definition of a dietary compound that mimics some aspects of CR...
  29. ncbi Signalling through RHEB-1 mediates intermittent fasting-induced longevity in C. elegans
    Sakiko Honjoh
    Department of Cell and Developmental Biology, Graduate School of Biostudies, Kyoto University, Sakyo ku, Kyoto, 606 8502, Japan
    Nature 457:726-30. 2009
    ..In mammals, two regimens of dietary restriction, intermittent fasting (IF) and chronic caloric restriction, have proven to extend lifespan and reduce the incidence of age-related disorders...
  30. ncbi Effect of short term calorie restriction on pro-inflammatory NF-kB and AP-1 in aged rat kidney
    K J Jung
    Department of Pharmacy, Pusan National University, Busan, Korea
    Inflamm Res 58:143-50. 2009
    ..To compare the effect of short-term calorie restriction (CR) on aging with that of already known long-term CR, the anti-inflammatory efficacy of 10-day CR was explored in aged rat kidney...
  31. pmc Sirt1 enhances skeletal muscle insulin sensitivity in mice during caloric restriction
    Simon Schenk
    Division of Endocrinology and Metabolism, Department of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093 0673, USA
    J Clin Invest 121:4281-8. 2011
    Skeletal muscle insulin resistance is a key component of the etiology of type 2 diabetes. Caloric restriction (CR) enhances the sensitivity of skeletal muscle to insulin...
  32. ncbi Sirtuin activators mimic caloric restriction and delay ageing in metazoans
    Jason G Wood
    Department of Pathology, Harvard Medical School, 77 Ave Louis Pasteur, Boston, Massachusetts 02115, USA
    Nature 430:686-9. 2004
    b>Caloric restriction extends lifespan in numerous species. In the budding yeast Saccharomyces cerevisiae this effect requires Sir2 (ref. 1), a member of the sirtuin family of NAD+-dependent deacetylases...
  33. pmc Different dietary restriction regimens extend lifespan by both independent and overlapping genetic pathways in C. elegans
    Eric L Greer
    Department of Genetics, Stanford University, Stanford, CA 94305, USA
    Aging Cell 8:113-27. 2009
    ..Understanding the genetic network by which different DR regimens extend lifespan has important implications for harnessing the full benefits of DR on lifespan and healthspan...
  34. pmc Dietary restriction suppresses proteotoxicity and enhances longevity by an hsf-1-dependent mechanism in Caenorhabditis elegans
    Katherine A Steinkraus
    Department of Pathology, University of Washington, Seattle, WA 98195, USA
    Aging Cell 7:394-404. 2008
    ..These findings demonstrate that dietary restriction confers a general protective effect against proteotoxicity and promotes longevity by a mechanism involving hsf-1...
  35. pmc Caloric restriction and resveratrol promote longevity through the Sirtuin-1-dependent induction of autophagy
    E Morselli
    INSERM, U848, Villejuif F 94805, France
    Cell Death Dis 1:e10. 2010
    b>Caloric restriction and autophagy-inducing pharmacological agents can prolong lifespan in model organisms including mice, flies, and nematodes...
  36. ncbi The biochemistry of sirtuins
    Anthony A Sauve
    Department of Pharmacology, Weill Medical College of Cornell University, New York, New York 10021, USA
    Annu Rev Biochem 75:435-65. 2006
    ..The biological, chemical, and structural characteristics of these unusual enzymes are discussed in this review...
  37. pmc The critical role of metabolic pathways in aging
    Nir Barzilai
    Department of Medicine, Albert Einstein College of Medicine, Bronx, New York, USA
    Diabetes 61:1315-22. 2012
    ..Some interventions designed to address features of aging, such as caloric restriction or visceral fat depletion, have succeeded in improving insulin action and life span in rodents...
  38. ncbi Calories and carcinogenesis: lessons learned from 30 years of calorie restriction research
    Stephen D Hursting
    Department of Nutritional Sciences, The University of Texas at Austin, 103 West 24th Street, Austin, TX 78712, USA
    Carcinogenesis 31:83-9. 2010
    ..These approaches will facilitate the translation of CR research into effective strategies for cancer prevention in humans...
  39. pmc Of mice and men: the benefits of caloric restriction, exercise, and mimetics
    Evi M Mercken
    Laboratory of Experimental Gerontology, National Institute on Aging, National Institutes of Health, 251 Bayview Boulevard, Baltimore, MD 21224, USA
    Ageing Res Rev 11:390-8. 2012
    ..For decades, research has shown that caloric restriction (CR) and exercise can postpone detrimental aspects of aging...
  40. pmc Genetic variation in the murine lifespan response to dietary restriction: from life extension to life shortening
    Chen Yu Liao
    Department of Physiology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    Aging Cell 9:92-5. 2010
    ..Although strains with shortened lifespan under 40% DR may not respond negatively under less stringent DR, the results raise the possibility that life extension by DR may not be universal...
  41. pmc Diet and exercise signals regulate SIRT3 and activate AMPK and PGC-1alpha in skeletal muscle
    Orsolya M Palacios
    USDA ARS Children s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA
    Aging (Albany NY) 1:771-83. 2009
    ..protein levels in skeletal muscle are sensitive to diet, for SIRT3 expression increases by fasting and caloric restriction, yet it is decreased by high-fat diet...
  42. pmc Visceral adipose tissue modulates mammalian longevity
    Radhika Muzumdar
    Institute for Aging Research, Albert Einstein College of Medicine, Bronx, New York, NY 10461, USA
    Aging Cell 7:438-40. 2008
    b>Caloric restriction (CR) can delay many age-related diseases and extend lifespan, while an increase in adiposity is associated with enhanced disease risk and accelerated aging...
  43. ncbi How increased oxidative stress promotes longevity and metabolic health: The concept of mitochondrial hormesis (mitohormesis)
    Michael Ristow
    Dept of Human Nutrition, Institute of Nutrition, University of Jena, Germany
    Exp Gerontol 45:410-8. 2010
    ..Hence, the concept of mitohormesis provides a common mechanistic denominator for the physiological effects of physical exercise, reduced calorie uptake, glucose restriction, and possibly beyond...
  44. pmc Effect of 6-month calorie restriction on biomarkers of longevity, metabolic adaptation, and oxidative stress in overweight individuals: a randomized controlled trial
    Leonie K Heilbronn
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge 70808, USA
    JAMA 295:1539-48. 2006
    ..Whether prolonged calorie restriction affects biomarkers of longevity or markers of oxidative stress, or reduces metabolic rate beyond that expected from reduced metabolic mass, has not been investigated in humans...
  45. ncbi Calorie restriction and aging: review of the literature and implications for studies in humans
    Leonie K Heilbronn
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Am J Clin Nutr 78:361-9. 2003
    ..Future studies in nonobese humans should focus on the effects of prolonged CR on metabolic rate, on neuroendocrine adaptations, on diverse biomarkers of aging, and on predictors of chronic age-related diseases...
  46. ncbi Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans
    Malene Hansen
    Department of Biochemistry and Biophysics, University of California, 600 16th Street, San Francisco, CA 94158, USA
    Aging Cell 6:95-110. 2007
    ..Our findings link TOR, but not sir-2.1, to the longevity response induced by dietary restriction (DR) in C. elegans, and they suggest that neither TOR inhibition nor DR extends lifespan simply by reducing protein synthesis...
  47. pmc The neuroprotective properties of calorie restriction, the ketogenic diet, and ketone bodies
    Marwan Maalouf
    Department of Neurobiology, David Geffen School of Medicine, University of California, 63 323 CH5, Box 951763, Los Angeles, CA 90095 1763, USA
    Brain Res Rev 59:293-315. 2009
    ..The present review summarizes the neuroprotective effects of calorie restriction, of the ketogenic diet and of ketone bodies, and compares their putative mechanisms of action...
  48. ncbi Lifespan extension in Caenorhabditis elegans by complete removal of food
    Tammi L Kaeberlein
    Department of Microbiology, University of Washington, Seattle, WA, USA
    Aging Cell 5:487-94. 2006
    ..Removal of bacterial food also increases lifespan when initiated in postreproductive adults, suggesting that dietary restriction started during middle age can result in a substantial longevity benefit that is independent of reproduction...
  49. ncbi Effect of calorie restriction on the metabolic history of chronologically aging yeast
    Alexander A Goldberg
    Department of Biology, Concordia University, Montreal, Quebec, Canada
    Exp Gerontol 44:555-71. 2009
    ..Thus, our data suggest that longevity in chronologically aging yeast is programmed by the level of metabolic capacity and organelle organization they developed, in a diet-specific fashion, prior to entry into a non-proliferative state...
  50. pmc Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma
    Frederic Picard
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Nature 429:771-6. 2004
    ..As a reduction in fat is sufficient to extend murine lifespan, our results provide a possible molecular pathway connecting calorie restriction to life extension in mammals...
  51. pmc Calorie restriction and cancer prevention: metabolic and molecular mechanisms
    Valter D Longo
    The Andrus Gerontology Center, University of Southern California, Los Angeles, CA, USA
    Trends Pharmacol Sci 31:89-98. 2010
    ..Here, we discuss the link between nutritional interventions and cancer prevention with focus on the mechanisms that might be responsible for these effects in simple systems and mammals with a view to developing chemoprevention agents...
  52. pmc Metabolic reprogramming, caloric restriction and aging
    Rozalyn M Anderson
    Geriatric Research, Education and Clinical Center, William S Middleton Memorial Veterans Hospital, University of Wisconsin Madison, Madison, WI 53705, USA
    Trends Endocrinol Metab 21:134-41. 2010
    b>Caloric restriction (CR) without malnutrition slows the aging process and extends lifespan in diverse species by unknown mechanisms...
  53. ncbi Caloric restriction, the traditional Okinawan diet, and healthy aging: the diet of the world's longest-lived people and its potential impact on morbidity and life span
    Bradley J Willcox
    Pacific Health Research Institute, 846 South Hotel Street, Suite 301, Honolulu, HI 96813, USA
    Ann N Y Acad Sci 1114:434-55. 2007
    Long-term caloric restriction (CR) is a robust means of reducing age-related diseases and extending life span in multiple species, but the effects in humans are unknown...
  54. ncbi Modulation of age-induced apoptotic signaling and cellular remodeling by exercise and calorie restriction in skeletal muscle
    Emanuele Marzetti
    Department of Aging and Geriatric Research, University of Florida Institute on Aging, College of Medicine, Gainesville, FL 32610, USA
    Free Radic Biol Med 44:160-8. 2008
    ..The most recent evidence on the relevance of skeletal muscle apoptosis to sarcopenia, as well as its modulation by calorie restriction and exercise, is reviewed...
  55. pmc Converging pathways in lifespan regulation
    Sri Devi Narasimhan
    Program in Gene Function and Expression, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA
    Curr Biol 19:R657-66. 2009
    ..Ultimately, both the insulin/IGF-1 pathway and the pathway that mediates the effects of dietary restriction have evolved to respond to the nutritional status of an organism, which in turn affects its lifespan...
  56. ncbi Increasing healthy lifespan by suppressing aging in our lifetime: preliminary proposal
    Mikhail V Blagosklonny
    Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY, USA
    Cell Cycle 9:4788-94. 2010
    ....
  57. ncbi Overview of caloric restriction and ageing
    Edward J Masoro
    Barshop Center for Longevity and Aging Studies, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    Mech Ageing Dev 126:913-22. 2005
    ..action appears to be due to a restricted intake of energy, this dietary manipulation is referred to as caloric restriction (CR). CR extends life by slowing and/or delaying the ageing processes...
  58. pmc Attenuation of age-related changes in mouse neuromuscular synapses by caloric restriction and exercise
    Gregorio Valdez
    Department of Molecular and Cellular Biology and Center for Brain Science, Harvard University, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 107:14863-8. 2010
    ..Accordingly, the beneficial effects on neural function of caloric restriction and exercise, which are among the most effective anti-aging treatments known, might also be mediated by ..
  59. ncbi Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction
    Weiping Qin
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 281:21745-54. 2006
    ..The study provides a potentially novel pharmacological strategy for AD prevention and/or treatment...
  60. pmc Caloric restriction: is mammalian life extension linked to p53?
    Paola Tucci
    Medical Research Council, Toxicology Unit, Leicester University, Leicester LE1 9HN, UK
    Aging (Albany NY) 4:525-34. 2012
    b>Caloric restriction, that is limiting food intake, is recognized in mammals as the best characterized and most reproducible strategy for extending lifespan, retarding physiological aging and delaying the onset of age-associated diseases...
  61. pmc Biology's response to dieting: the impetus for weight regain
    Paul S MacLean
    University of Colorado Anschutz Medical Campus, Department of Medicine, Division of Endocrinology, Metabolism, and Diabetes, Center for Human Nutrition, Denver, Colorado, USA
    Am J Physiol Regul Integr Comp Physiol 301:R581-600. 2011
    ..To be successful in the long term, our strategies for preventing weight regain may need to be just as comprehensive, persistent, and redundant, as the biological adaptations they are attempting to counter...
  62. pmc Adenosine nucleotide biosynthesis and AMPK regulate adult life span and mediate the longevity benefit of caloric restriction in flies
    Drew Stenesen
    Department of Developmental Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Cell Metab 17:101-12. 2013
    ....
  63. pmc Caloric restriction leads to high marrow adiposity and low bone mass in growing mice
    Maureen J Devlin
    Center for Advanced Orthopedic Studies, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    J Bone Miner Res 25:2078-88. 2010
    The effects of caloric restriction (CR) on the skeleton are well studied in adult rodents and include lower cortical bone mass but higher trabecular bone volume...
  64. ncbi SIRT2 deacetylates FOXO3a in response to oxidative stress and caloric restriction
    Fei Wang
    USDA ARS Children s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA
    Aging Cell 6:505-14. 2007
    ..In yeast, the Sir2 gene and its homolog Hst2 independently mediate the action of caloric restriction on lifespan extension...
  65. pmc Modulation of skeletal muscle insulin signaling with chronic caloric restriction in cynomolgus monkeys
    Zhong Q Wang
    Division of Nutrition and Chronic Diseases, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA, USA
    Diabetes 58:1488-98. 2009
    b>Caloric restriction (CR) has been shown to retard aging processes, extend maximal life span, and consistently increase insulin action in experimental animals...
  66. pmc Caloric restriction or resveratrol supplementation and ageing in a non-human primate: first-year outcome of the RESTRIKAL study in Microcebus murinus
    Alexandre Dal-Pan
    Mecanismes Adaptatifs et Evolution, UMR 7179 Centre National de la Recherche Scientifique, Museum national d histoire naturelle, 1 avenue du petit château, Brunoy, France
    Age (Dordr) 33:15-31. 2011
    ..and behavioural functions was initiated in 38-month-old mouse lemurs (Microcebus murinus) to test whether caloric restriction (CR) or a potential mimetic compound, resveratrol (RSV), can delay the ageing process and the onset of age-..
  67. pmc Long-term calorie restriction, but not endurance exercise, lowers core body temperature in humans
    Andreea Soare
    Division of Geriatrics and Nutritional Sciences and Center for Human Nutrition, Washington University School of Medicine, St Louis, Missouri, USA
    Aging (Albany NY) 3:374-9. 2011
    ..This adaptation is likely due to CR itself, rather than to leanness, and may be involved in slowing the rate of aging...
  68. ncbi Effects of yo-yo diet, caloric restriction, and olestra on tissue distribution of hexachlorobenzene
    Ronald J Jandacek
    Department of Pathology and Laboratory Medicine, University of Cincinnati School of Medicine, Cincinnati, OH 45237, USA
    Am J Physiol Gastrointest Liver Physiol 288:G292-9. 2005
    ..They enter the body in food and are stored in adipose tissue. Loss of body fat through caloric restriction mobilizes stored lipophilic xenobiotics and results in distribution to other tissues...
  69. pmc Randomized clinical trials of weight loss maintenance: a review
    Melanie Warziski Turk
    Department of Health and Community Systems, University of Pittsburgh School of Nursing, Pennsylvania 15261, USA
    J Cardiovasc Nurs 24:58-80. 2009
    ....
  70. pmc Temporal linkage between the phenotypic and genomic responses to caloric restriction
    Joseph M Dhahbi
    BioMarker Pharmaceuticals, Incorporated, 900 East Hamilton Avenue, Campbell, CA 95008, USA
    Proc Natl Acad Sci U S A 101:5524-9. 2004
    b>Caloric restriction (CR), the consumption of fewer calories while avoiding malnutrition, decelerates the rate of aging and the development of age-related diseases...
  71. pmc Tor1/Sch9-regulated carbon source substitution is as effective as calorie restriction in life span extension
    Min Wei
    Andrus Gerontology Center, University of Southern California, Los Angeles, CA, USA
    PLoS Genet 5:e1000467. 2009
    ....
  72. pmc Calorie restriction: is AMPK a key sensor and effector?
    Carles Canto
    Laboratory of Integrative and Systems Physiology and Nestle Chair in Energy Metabolism, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland
    Physiology (Bethesda) 26:214-24. 2011
    ..In this review, we will discuss the possible role of AMPK in the beneficial effects of calorie restriction on health and life span...
  73. pmc An AMPK-FOXO pathway mediates longevity induced by a novel method of dietary restriction in C. elegans
    Eric L Greer
    Department of Genetics, Cancer Biology Program, Stanford University, Stanford, California 94305, USA
    Curr Biol 17:1646-56. 2007
    ..AMP-activated protein kinase (AMPK) is activated by a decrease in energy levels, raising the possibility that AMPK might mediate lifespan extension by DR...
  74. ncbi Intermittent fasting and caloric restriction ameliorate age-related behavioral deficits in the triple-transgenic mouse model of Alzheimer's disease
    Veerendra Kumar Madala Halagappa
    Laboratory of Neurosciences, National Institute on Aging, Intramural Research Program, Baltimore, MD 21224, USA
    Neurobiol Dis 26:212-20. 2007
    ..We conclude that CR and IF dietary regimens can ameliorate age-related deficits in cognitive function by mechanisms that may or may not be related to Abeta and tau pathologies...
  75. pmc Effects of long-term calorie restriction and endurance exercise on glucose tolerance, insulin action, and adipokine production
    Luigi Fontana
    Washington University School of Medicine, St Louis, MO 63110, USA
    Age (Dordr) 32:97-108. 2010
    ..This impaired glucose tolerance is associated with lower circulating levels of IGF-1, total testosterone, and triiodothyronine, which are typical adaptations to life-extending CR in rodents...
  76. pmc Genes and gene expression modules associated with caloric restriction and aging in the laboratory mouse
    William R Swindell
    Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109 2200, USA
    BMC Genomics 10:585. 2009
    b>Caloric restriction (CR) counters deleterious effects of aging and, for most mouse genotypes, increases mean and maximum lifespan...
  77. pmc Sir2 mediates longevity in the fly through a pathway related to calorie restriction
    Blanka Rogina
    Department of Genetics and Developmental Biology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030, USA
    Proc Natl Acad Sci U S A 101:15998-6003. 2004
    ..These data lead us to propose a genetic pathway by which calorie restriction extends life span and provides a framework for genetic and pharmacological studies of life span extension in metazoans...
  78. pmc Caloric restriction shortens lifespan through an increase in lipid peroxidation, inflammation and apoptosis in the G93A mouse, an animal model of ALS
    Barkha P Patel
    School of Kinesiology and Health Science, York University, Toronto, Ontario, Canada
    PLoS ONE 5:e9386. 2010
    b>Caloric restriction (CR) extends lifespan through a reduction in oxidative stress, delays the onset of morbidity and prolongs lifespan...
  79. pmc Delayed and accelerated aging share common longevity assurance mechanisms
    Björn Schumacher
    Department of Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands
    PLoS Genet 4:e1000161. 2008
    ....
  80. pmc Gain of survival signaling by down-regulation of three key miRNAs in brain of calorie-restricted mice
    Amit Khanna
    Department of Biochemistry and Molecular Biology, University of Louisville School of Medicine, Louisville, KY 40202, USA
    Aging (Albany NY) 3:223-36. 2011
    ....
  81. pmc Dietary energy restriction modulates the activity of AMP-activated protein kinase, Akt, and mammalian target of rapamycin in mammary carcinomas, mammary gland, and liver
    Weiqin Jiang
    Cancer Prevention Laboratory, Colorado State University, Fort Collins, Colorado 80523, USA
    Cancer Res 68:5492-9. 2008
    ....
  82. ncbi Life extension in the dwarf mouse
    Andrzej Bartke
    Geriatrics Research, Department of Medicine, Southern Illinois University School of Medicine, Springfield, Illinois 62794, USA
    Curr Top Dev Biol 63:189-225. 2004
    ..share many phenotypic characteristics with genetically normal (wild-type) animals subjected to prolonged caloric restriction (CR) but are not CR mimetics...
  83. pmc Mitochondrial biogenesis and healthy aging
    Guillermo Lopez-Lluch
    Centro Andaluz de Biologia del Desarrollo, Universidad Pablo de Olavide CSIC, Carretera de Utrera Km 1, 41013 Sevilla, Spain
    Exp Gerontol 43:813-9. 2008
    ....
  84. pmc Inhibition of thymic adipogenesis by caloric restriction is coupled with reduction in age-related thymic involution
    Hyunwon Yang
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    J Immunol 183:3040-52. 2009
    ..Furthermore, CR prevented the deterioration of the peripheral TCR repertoire diversity in older animals. Collectively, our findings demonstrate that reducing proadipogenic signaling in thymus via CR may promote thymopoiesis during aging...
  85. pmc Caloric restriction and aging: studies in mice and monkeys
    Rozalyn M Anderson
    Wisconsin National Primate Research Center, Madison, Wisconsin, USA
    Toxicol Pathol 37:47-51. 2009
    It is widely accepted that caloric restriction (CR) without malnutrition delays the onset of aging and extends lifespan in diverse animal models including yeast, worms, flies, and laboratory rodents...
  86. ncbi Free radicals and aging
    Gustavo Barja
    Department of Animal Physiology II, Faculty of Biology, Complutense University, Madrid 28040, Spain
    Trends Neurosci 27:595-600. 2004
    ..These are the two known traits connecting oxidative stress with aging. Furthermore, caloric restriction, which decreases the rate of aging, proportionately decreases mitochondrial oxygen radical generation, ..
  87. pmc Increased susceptibility of aging kidney to ischemic injury: identification of candidate genes changed during aging, but corrected by caloric restriction
    G Chen
    Department of Systems Biology and Translational Medicine, College of Medicine, Texas A and M University System Health Science Center, College Station, TX 77843 1114, USA
    Am J Physiol Renal Physiol 293:F1272-81. 2007
    ..Importantly, caloric restriction attenuated the increased susceptibility to injury...
  88. pmc Caloric restriction may reverse age-related autonomic decline in humans
    Phyllis K Stein
    HRV Laboratory, Washington University School of Medicine, St Louis, MO 63110, USA
    Aging Cell 11:644-50. 2012
    b>Caloric restriction (CR) retards aging in laboratory rodents. No information is available on the effects of long-term CR on physiologic markers of aging and longevity in humans...
  89. ncbi Calorie restriction extends the chronological lifespan of Saccharomyces cerevisiae independently of the Sirtuins
    Daniel L Smith
    Department of Biochemistry and Molecular Genetics, University of Virginia Health System, School of Medicine, Charlottesville, VA 22908, USA
    Aging Cell 6:649-62. 2007
    ....
  90. ncbi Caloric restriction primes mitochondria for ischemic stress by deacetylating specific mitochondrial proteins of the electron transport chain
    Ken Shinmura
    Division of Geriatric Medicine, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Circ Res 109:396-406. 2011
    b>Caloric restriction (CR) confers cardioprotection against ischemia/reperfusion injury. However, the exact mechanism(s) underlying CR-induced cardioprotection remain(s) unknown...
  91. ncbi Resveratrol and life extension
    Beamon Agarwal
    Institute for Diabetes, Obesity, and Metabolism, Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA
    Ann N Y Acad Sci 1215:138-43. 2011
    ..In rodents, caloric restriction (CR) extends lifespan by up to 50%...
  92. pmc Moderate caloric restriction during gestation in rats alters adipose tissue sympathetic innervation and later adiposity in offspring
    Ana Paula Garcia
    Laboratory of Molecular Biology, University of Balearic Islands and CIBER Fisiopatología de la Obesidad y Nutrición, Palma de Mallorca, Spain
    PLoS ONE 6:e17313. 2011
    ..Here we aimed to evaluate whether moderate caloric restriction during early pregnancy in rats affects white adipose tissue (WAT) sympathetic innervation in the offspring, ..
  93. pmc Caloric restriction reduces growth of mammary tumors and metastases
    Mariana S De Lorenzo
    Department of Cell Biology and Molecular Medicine and The Cardiovascular Research Institute, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ 07103, USA
    Carcinogenesis 32:1381-7. 2011
    We investigated the effects of caloric restriction (CR) on growth of tumors and metastases in the 4T1 mammary tumor model and found that CR, compared with normal diet, reduced the growth of mammary tumors and metastases and the total ..
  94. ncbi A distinct adipose tissue gene expression response to caloric restriction predicts 6-mo weight maintenance in obese subjects
    David M Mutch
    INSERM, U, Nutriomique, Paris, France
    Am J Clin Nutr 94:1399-409. 2011
    ..Weight loss has been shown to reduce risk factors associated with cardiovascular disease and diabetes; however, successful maintenance of weight loss continues to pose a challenge...
  95. ncbi Effects of maternal L-citrulline supplementation on renal function and blood pressure in offspring exposed to maternal caloric restriction: the impact of nitric oxide pathway
    You Lin Tain
    Department of Pediatrics, Chang Gung Memorial Hospital Kaohsiung Medical Center, Chang Gung University, College of Medicine, Taiwan
    Nitric Oxide 23:34-41. 2010
    ..to elucidate whether NO deficiency evolves to kidney disease vulnerability in offspring from mothers with caloric restriction diets and whether maternal L-citrulline (L-Cit) supplementation can prevent this...
  96. ncbi A meta-analysis of caloric restriction gene expression profiles to infer common signatures and regulatory mechanisms
    Michael Plank
    Integrative Genomics of Ageing Group, Institute of Integrative Biology, University of Liverpool, Liverpool L69 7ZB, UK
    Mol Biosyst 8:1339-49. 2012
    b>Caloric restriction, a reduction in calorie intake without malnutrition, retards age-related degeneration and extends lifespan in several organisms. CR induces multiple changes, yet its underlying mechanisms remain poorly understood...
  97. ncbi The retardation of aging by caloric restriction: its significance in the transgenic era
    Jamie L Barger
    Wisconsin Primate Research Center and Department of Medicine, University of Wisconsin Madison, Madison, WI 53705, USA
    Exp Gerontol 38:1343-51. 2003
    The retardation of aging and diseases by caloric restriction (CR) is a widely-studied and robust phenomenon...
  98. ncbi Short-term consumption of a resveratrol-containing nutraceutical mixture mimics gene expression of long-term caloric restriction in mouse heart
    J L Barger
    LifeGen Technologies, LLC, Madison, WI 53719, USA
    Exp Gerontol 43:859-66. 2008
    ..area of aging research is focused on identifying compounds having the ability to mimic the effects of caloric restriction (CR)...
  99. pmc Caloric restriction in humans
    John O Holloszy
    Division of Geriatrics and Nutritional Science, Washington University School of Medicine, 4566 Scott Avenue, Campus Box 8113, St Louis, MO 63110, USA
    Exp Gerontol 42:709-12. 2007
    ....
  100. pmc Life span extension by calorie restriction depends on Rim15 and transcription factors downstream of Ras/PKA, Tor, and Sch9
    Min Wei
    Andrus Gerontology Center, University of Southern California, Los Angeles, California, United States of America
    PLoS Genet 4:e13. 2008
    ..Notably, the anti-aging effect caused by the inactivation of both pathways is much more potent than that caused by CR...
  101. ncbi SIR2: a potential target for calorie restriction mimetics
    Danica Chen
    Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Trends Mol Med 13:64-71. 2007
    ..The SIR2 family represents an evolutionarily conserved lifespan regulator. Modulating the activity of SIR2 might provide effective CR mimetics to combat diseases of aging...

Research Grants74

  1. Response to and signals of caloric restriction and intermittent feeding regimens
    MARC KOPEL HELLERSTEIN; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Caloric restriction (CR) extends life-span and delays diseases in animal models. This remarkable observation has been difficult to translate into human health benefits, for two primary reasons...
  2. Role of SCD1 and Dietary Methionine Restriction on Energy Homeostasis
    ERIC PAUL PLAISANCE; Fiscal Year: 2011
    ..Dietary methionine restriction (MR) has been used as a mimetic of caloric restriction to increase longevity in rodents...
  3. Neuroimaging Assessments of Brain Integrity in Aging Mice
    Ai Ling Lin; Fiscal Year: 2013
    ..found skills to the investigation of the mechanisms of action of aging and potential protective effects of caloric restriction (CR);and, 4) to have hands-on training in behavioral testing for rodents and identify the association ..
  4. Oxidative Stress in Chronic Kidney Disease
    Talat Alp Ikizler; Fiscal Year: 2012
    ..models and available human studies, healthy lifestyle interventions, such as aerobic exercise and dietary caloric restriction, have demonstrated antioxidant effects mediated via induction of mitochondrial biogenesis, induction of ..
  5. RYGB Improves Metabolism by Interrupting the Gastric Adipose Tissue Axis
    Naji N Abumrad; Fiscal Year: 2013
    ..Two cohorts of matched controls will be studied before and 7 days following caloric restriction (to match the post-RYGB diet) without stomach interruption: one with LAGB (laparoscopic adjusted gastric ..
  6. Effect of Perinatal Diet on Developmental Programming of the Skeleton
    Mary L Bouxsein; Fiscal Year: 2010
    ..Perinatal diet is of particular interest because maternal caloric restriction (CR) and high fat (HF) diet have each been shown to trigger developmental programming that increases the ..
  7. Molecular Genetics of Caloric Restriction in Aging Flies
    Blanka Rogina; Fiscal Year: 2013
    b>Caloric restriction (CR) is the surest way of increasing life span and delaying the onset of age-related symptoms in animals...
  8. Vitamin D Effect on Body Composition During Behavioral Weight Loss in Women
    ANNE M MCTIERNAN; Fiscal Year: 2013
    ..postmenopausal women (50-75 y) undergoing a 12-month lifestyle change weight loss program through caloric restriction and aerobic exercise...
  9. Skeletal Muscle Mitochondrial Adaptations to a Two-Year Caloric Restiction
    STEVEN RICHARD SMITH; Fiscal Year: 2012
    ..These totally novel studies of mitochondrial adaptations to caloric restriction will directly test the first and critical aspects of the oxidative stress theory of aging in the longest ..
  10. Extending Sleep in Obese Adults to Promote Weight Loss
    Ann E Rogers; Fiscal Year: 2010
    ..to traditional weight loss programs;2) comparing the efficacy of sleep extension in combination with caloric restriction and exercise to a traditional weight control program consisting of caloric restriction and exercise for ..
  11. The AMP-activated protein kinase (AMPK) antagonizes inflammation through SIRT1
    Hang Shi; Fiscal Year: 2012
    ..which also functions as an energy sensor, is an NAD+dependent deacetylase that mediates the effects of caloric restriction to extend longevity...
  12. Systemic Factors that Maintain a Young Liver Phenotype
    Roy G Smith; Fiscal Year: 2012
    ..b>Caloric restriction (CR) maintains health during aging and increases longevity;however, the molecular mediator(s) is unknown...
  13. CONTROL OF GONADOTROPIN SECRETION DURING LACTATION
    Kevin L Grove; Fiscal Year: 2013
    ..Our studies use two models of negative energy balance, lactation and caloric restriction, and have shown that kisspeptin signaling is greatly suppressed during these states...
  14. Generating Blood-based Diagnosis for Alzheimer Disease
    Eugenia Wang; Fiscal Year: 2012
    ..SIRT1 is a member of the 7-member Silent Information Regulator protein family. Caloric restriction extends longevity through triggering expression of SIRT1, which can also be mimicked by resveratrol, a red ..
  15. The Regulation of Mitochondrial Function by SIRT3
    Qiang Tong; Fiscal Year: 2010
    Dietary caloric restriction is the most potent intervention prolonging life span, as well as reducing age-related diseases, such as obesity and diabetes...
  16. Akt, cellular senescence, and lifespan
    Nissim Hay; Fiscal Year: 2010
    The coupling between lifespan and energy metabolism is well documented, and caloric restriction was shown to extend the lifespan of a wide spectrum of organisms...
  17. Exploring the Impact of Negative Energy Balance in Men with Prostate Cancer
    Wendy Demark-Wahnefried; Fiscal Year: 2013
    ..Preclinical studies suggest that negative energy balance from both caloric restriction and increased physical activity that results in weight loss may suppress several hormonal and inflammatory ..
  18. AREA: Rapamycin, ambient temperature, and longevity
    Steven J Swoap; Fiscal Year: 2010
    ..in mice Until recently, additives to the diet have been unable to mimic the lifespan-extension effects of caloric restriction. However, it was very recently shown that the addition of rapamycin, an immunosuppressant drug, to the diet ..
  19. Mechanisms of Lipid-Induced Hepatic Insulin Resistance
    Gerald I Shulman; Fiscal Year: 2013
    ..dicarboxylate and citrate transporter and has been shown to promote longevity in a manner akin to caloric restriction in flies, but its role in mammals is unknown...
  20. Rev-ERBa Regulates Mitochondrial Biogenesis, Adiposity, and Insulin Action
    Thomas H Reynolds; Fiscal Year: 2010
    ..insulin sensitivity is associated with an increase in Akt/PKB expression, a finding that is distinct from caloric restriction induced weight loss...
  21. Attenuation of androgen deprivation therapy-induced metabolic syndrome by diet
    Oleg Varlamov; Fiscal Year: 2013
    ..in rhesus monkeys brought about by a high fat diet (HFD) leads to obesity and insulin resistance, while caloric restriction results in improved insulin sensitivity, and decreased body fat...
  22. Affinity Tagging of Adipocyte Nuclei to Examine Epigenetic Controls in Obesity
    Richard Brian Meagher; Fiscal Year: 2013
    ..and differences among nearly genetically identically individuals in their response to obesogenic diets, caloric restriction, and exercise...
  23. Biology of Aerobic Capacity and Insulin Resistance
    Charles F Burant; Fiscal Year: 2012
    ..Interestingly, the HCR colony was found to have gene expression profiles suggesting that they perceive a caloric restriction, despite an increase in food intake...
  24. Oxaloacetate's Brain Effects
    Russell H Swerdlow; Fiscal Year: 2013
    ..You can purchase it as a nutritional supplement. One manufacturer markets it as a caloric restriction mimetic and "longevity supplement". These claims are based on a 2009 study in which OAA-treated C...
  25. The Effect of Diet and Nutrients on the Progression and Treatment of Prostate Can
    George Thomas; Fiscal Year: 2013
    ..Consistent with these observations, it has been noted that caloric restriction acts to prevent cancer progression...
  26. Mitochondrial Thioredoxin, Caloric Restriction, and Age-related Hearing Loss
    Shinichi Someya; Fiscal Year: 2013
    ..Evidence indicates that caloric restriction (CR) leads to a reduction in the production of reactive oxygen species (ROS) in multiple tissues, while ..
  27. Molecular Mechanisms of Rapamycin's effects on Health and longevity.
    Joseph A Baur; Fiscal Year: 2013
    ..is mTORC1, a nutrient sensing kinase whose homolog has been implicated in the extension of lifespan by caloric restriction (CR) in lower organisms...
  28. Changes in antioxidants and susceptibility to parasites
    DEBORAH KRISTAN; Fiscal Year: 2012
    ..of cytokines and immunoglobins, (2) host defense against nematode worms includes the use of ROS, and (3) caloric restriction typically decreases production of ROS and alters production of associated antioxidants...
  29. Transcriptional Architecture and Chromatin Landscape of Circadian Clocks in Aging
    Joseph S Takahashi; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Caloric restriction (CR) is one of the few regimens that enhances longevity in mammals, yet the mechanisms underlying this beneficial effect have been elusive...
  30. Epidemiology of lens aging in older women
    JASON LEIGH SANDERS; Fiscal Year: 2013
    ..This has been most clearly demonstrated in animal models with genetic manipulation and caloric restriction. In these systems mortality rate has been the primary marker of aging, but for human studies in vivo ..
  31. Patterns of Infusion of Anorexigenic Substances that Reduce Obesity
    ROGER REIDELBERGER; Fiscal Year: 2012
    ..It remains to be determined whether leptin replacement increases the efficacy of caloric restriction or pharmacotherapy to produce weight loss in obese individuals...
  32. RESOURCE FOR RAT GENETIC MODELS OF AEROBIC CAPACITY
    Steven Loyal Britton; Fiscal Year: 2013
    ..of differential for aging and longevity between LCR and HCR (Russ Hepple), b) test if exercise or caloric restriction in very young LCR or HCR has a long-term positive "imprinting" effect on metabolic endpoints (Charles ..
  33. Weight Loss, Inflammation, and Vascular Endothelial Function in Older Adults
    Douglas R Seals; Fiscal Year: 2010
    ..The proposed research will determine if caloric restriction- induced weight loss improves vascular endothelium-dependent dilation (EDD), a clinically important marker ..
  34. Sir2 Regulates AMPK and Lipid Metabolism in Diabetes
    Mengwei Zang; Fiscal Year: 2012
    ..ortholog of silent information regulator 2 (Sir2), is an NAD-dependent deacetylase mediates the effects of caloric restriction to expend lifespan...
  35. IN VIVO REGULATION OF PROTEIN TURNOVER BY HORMONES
    K Sreekumaran Nair; Fiscal Year: 2013
    ..We expect caloric restriction (CR) to reduce oxidative stress by reducing ROS production and thus decrease oxidative damage to proteins ..
  36. Obesity, Inflammation and BPH
    Simon W Hayward; Fiscal Year: 2013
    ..The second aim will examine the reversibility of these phenotypic and inflammatory changes using caloric restriction and Roux-en-Y gastric bypass (RYGB) surgery...
  37. SIRT1, AMPK , and hepatocyte nutrient sensing
    LAUREN NELSON DISE; Fiscal Year: 2012
    ..that can be activated by fasting and are thought to account for the increased longevity associated with caloric restriction. AMP-activated protein kinase (AMPK) is a fuel-sensing molecule that increases ATP production and decreases ..
  38. Discovery of genes that extend yeast lifespan: Aging in immobilized cell reactors
    RAPHAEL ROSENZWEIG; Fiscal Year: 2009
    ..b>Caloric restriction appears to extend lifespan in all species studied, including yeast...
  39. Targeting the lipid synthesis enzyme, DGAT1, for breast cancer prevention
    IVAN PETER URAY; Fiscal Year: 2013
    ..Targeted deletion of both alleles of the DGAT1 gene in mice mimics the phenotype observed under caloric restriction and increases insulin sensitivity, suppresses IGF levels, reduces fat stores and inflammation in the ..
  40. Cognitive/Brain Effects of Adding Weight Loss to Exercise in Obese Older Adults
    Christina E Hugenschmidt; Fiscal Year: 2013
    ..Thus, it is unknown whether adding caloric restriction to an aerobic exercise intervention provides an additive benefit on cognition, and brain structure and ..
  41. Metabolic and Endocrine Effects of Bariatric Surgery
    Judith Korner; Fiscal Year: 2013
    ..to greater weight loss and improvement in glucose control after RYGB and SG compared with LAGB and dietary caloric restriction. The main objectives of this proposal are to further delineate the metabolic and endocrine changes that ..
  42. The Role of Somatic Copy Number Changes in Aging
    REBECCA I TORENE; Fiscal Year: 2013
    ..Do CNAs accumulate over time? Furthermore, the mouse samples in this study have either been subjected to a caloric restriction or ad libitum diet...
  43. Gender Differences in Caloric Restriction Cardioprotection
    Lin Yan; Fiscal Year: 2010
    ..There are two major hypotheses: Hypothesis A: Caloric restriction protects the heart of male mice from chronic catecholamine stress, but this is not observed in female mice...
  44. Novel Energy Restriction-Mimetic Agents for Prostate Cancer Prevention
    Ching Shih Chen; Fiscal Year: 2013
    ..to glycolytic inhibition, of which the proof-of-concept is provided by the in vivo efficacy of dietary caloric restriction and natural product-based energy restriction-mimetic agents (ERMAs) such as resveratrol and 2-deoxyglucose (..
  45. Effects of recombinant human leptin in nonalcoholic fatty liver disease (NAFLD)
    Elif Arioglu Oral; Fiscal Year: 2013
    ..therapy in 40 men with NAFLD/NASH and RLD against placebo whose diets will be controlled with moderate caloric restriction in a double-blind design for 1 year...
  46. Caloric restriction, exercise, and glucoregulation in humans
    Edward P Weiss; Fiscal Year: 2012
    ..RESEARCH PLAN: I will conduct a randomized trail to assess the hypothesis that weight losses induced by caloric restriction (CR) and by exercise (EX) improve glucose tolerance and insulin action through partly distinct mechanisms ..
  47. Control of Yeast Life Span
    Kurt W Runge; Fiscal Year: 2013
    ..pombe that recapitulates the evolutionarily conserved properties of lifespan extension by caloric restriction and stress resistance of long-lived cells...
  48. Depot-specific Adipogenesis in a Novel Mouse Model of Extended Lifespan
    Cheryl A Conover; Fiscal Year: 2013
    ..and maximum lifespan compared to wild-type littermates, without evidence of endocrine abnormalities or caloric restriction. However, the particular mechanisms underlying this longevity phenotype are poorly understood...
  49. Role of SIRT1 in vasoprotection
    ZOLTAN ISTVAN UNGVARI; Fiscal Year: 2013
    ..Previous studies indicate that caloric restriction (CR) attenuates the age- related increase in oxidative stress and increases lifespan...
  50. Impact of CR on inflammasome driven immune-metabolic interactions.
    Vishwa Deep Dixit; Fiscal Year: 2013
    ..b>Caloric restriction remains one of the most robust strategies to extend healthspan and reduce inflammation in animal models...
  51. Metabolic regulators in the mechanisms of caloric restriction
    Rozalyn M Anderson; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Caloric restriction (CR) delays the onset of aging and extends lifespan in diverse experimental organisms through an unknown mechanism...
  52. Can Rapamycin Retard Age-Related Diseases?
    Arlan G Richardson; Fiscal Year: 2010
    ..It took 2 decades of research funded through "normal" NIH-mechanisms to establish that caloric restriction increased the healthspan of rodents, i.e...
  53. Longevity and Stress Resistance
    Stephen F Vatner; Fiscal Year: 2013
    ..out, KO) was a model of longevity and planned to compare it to the most widely studied model of longevity, caloric restriction (CR)...
  54. Mechanisms of Energy Balance and Cancer Prevention
    ANNE M MCTIERNAN; Fiscal Year: 2010
    ..Project 1 will investigate, in a controlled feeding study, the role of caloric restriction plus a low glycemic load diet vs...
  55. Mechanisms and Effectiveness of Weight Loss Methods on Diabetes and Sleep Apnea
    Jeanne M Clark; Fiscal Year: 2012
    ..We hypothesize that a) early metabolic improvements are due to a combination of caloric restriction and changes in the gut-neuroendocrine axis, whereas b) later improvements are related to reductions in ..
  56. Gastric bypass surgery alters the regulation of food reward
    Andras Hajnal; Fiscal Year: 2013
    ..e. caloric restriction vs. GBS). The second and third aims will mechanistically address the underlying dynamic and static (i.e...
  57. Does SIRT1 regulate mammalian health and longevity?
    Joseph A Baur; Fiscal Year: 2011
    Since the 1930s it has been known that a severe reduction in energy intake (caloric restriction, CR) delays the onset of most age-related diseases and extends both mean and maximum lifespan in mammals...
  58. Role of the Central Amygdala in Ghrelin-Mediated Reward-Based Eating Behavior
    Jeffrey M Zigman; Fiscal Year: 2013
    ..We will determine if rises in ghrelin that occur upon ghrelin injection or naturally upon caloric restriction activate CA CRF neurons...
  59. Effect of aging on enteric neural stem cells is dependent on the PI3K/Akt pathway
    Laren Becker; Fiscal Year: 2013
    ..abstract_text> ..
  60. Hepatic Mitochondria and Insulin Resistance in Fatty Liver and Type 2 Diabetes
    RANDY SCOTT RECTOR; Fiscal Year: 2013
    ..2) Determine the effectiveness of daily exercise vs. caloric restriction (with and without metformin) in the treatment of NAFLD and type 2 diabetes...
  61. Mechanisms of Caloric Restriction and Mimetic Vasoprotection in Old Arteries
    ANTHONY JOHN DONATO; Fiscal Year: 2013
    ..One hypothesis is that the chronic reduction of caloric intake (Caloric Restriction;CR) can activate cellular and molecular events that prevent age-related arterial dysfunction...
  62. Sirtuins in Glaucomatous Optic Neuropathy
    Robert N Weinreb; Fiscal Year: 2013
    ..Activation of Sirt1 is essential to caloric restriction-induced reduction of age-related morbidity and increase of lifespan...
  63. SIRT1 Overexpression in Cellular Mitochondrial Metabolism and Function
    James Russell; Fiscal Year: 2009
    ..family of NAD+dependent deacetylases, which is proposed to be responsible for health benefits provided by caloric restriction. Furthermore, resveratrol found in the skin of red grapes increases the activity SIRT1, prolongs life-span ..
  64. TNF ALPHA REG OF THE GROWTH HORMONE/IGF-1 AXIS WITH AGE
    William Sonntag; Fiscal Year: 2000
    ..Enhanced secretion of TNFa has been detected in abdominal adipose tissue of older animals and moderate caloric restriction, which decreases adipose tissue mass and potentially decreases plasma TNFa, restores both the decrease in ..
  65. TRH in mediating the bradycardia of caloric restriction
    Steven Swoap; Fiscal Year: 2005
    ..b>Caloric restriction (CR) significantly ameliorates the elevated heart rate (HR) seen in obesity, as well as lowering resting HR ..
  66. Does CR Alter the Metabolic Rate of Specific Tissues
    Roger McCarter; Fiscal Year: 2004
    Decreased metabolic rate (MR) is widely believed to play a major role in the anti-aging effects of caloric restriction (CR)...
  67. Effect of exercise and weight loss on adipose tissue biology
    Anne McTiernan; Fiscal Year: 2009
    ..There will be ancillary to a funded human clinical trial of exercise and caloric restriction in overweight or obese, previously sedentary, postmenopausal women...
  68. Growth Hormone, IGF-1 and Age-related Pathogenesis
    William Sonntag; Fiscal Year: 2003
    ..g. moderate caloric restriction) alter specific pathological profiles and decrease total pathological burden...
  69. CATECHOLAMINE MODULATION OF THYROID HORMONE METABOLISM
    Harvey Katzeff; Fiscal Year: 1992
    Chronic exercise programs have several advantages when compared to caloric restriction for the treatment of obesity. Chronic exercise produces similar losses of fat mass as underfeeding but lean body mass is maintained...
  70. Caloric Restriction and Aging in Humans
    John Holloszy; Fiscal Year: 2009
    ..Slowing of primary aging results in an increase in maximal life span. Caloric restriction (CR) slows primary aging in various short-lived organisms, such as guppies, flies, mice and rats...
  71. Genetic Model of Caloric Restriction
    Blanka Rogina; Fiscal Year: 2002
    DESCRIPTION (provided by applicant) Caloric restriction (CR) has emerged as the most successful way to extend the lifespan in several different experimental organisms...
  72. DOES WEIGHT LOSS REDUCE MORTALITY RATE AMONG OBESE RATS?
    David Allison; Fiscal Year: 2002
    ..The conjecture that WL will increase longevity is bolstered by animal research showing that caloric restriction (CR) increases longevity even if started in mid-life...
  73. Inositol Signaling in C. elegans Senescence and Diapause
    GARY B RUVKUN; Fiscal Year: 2010
    ..elegans. This is reminiscent and may be mechanistically related to the longevity increase caused by caloric restriction in mammals...
  74. Metabolic Regulation in Aging and Caloric Restriction
    Blanka Rogina; Fiscal Year: 2002
    b>Caloric restriction (CR) has emerged as the most successful way to extend the life span of a number of experimental organisms. CR slows down physiological decline and occurrence of some of the age-related pathology of animals...