therapeutic chemoembolization

Summary

Summary: Administration of antineoplastic agents together with an embolizing vehicle. This allows slow release of the agent as well as obstruction of the blood supply to the neoplasm.

Top Publications

  1. ncbi Usefulness of cone-beam volume CT with flat panel detectors in conjunction with catheter angiography for transcatheter arterial embolization
    Shingo Kakeda
    Department of Radiology, University of Occupational and Environmental Health School of Medicine, 1 1 Iseigaoka, Yahatanishi ku, Kitakyushu 807 8555, Japan
    J Vasc Interv Radiol 18:1508-16. 2007
  2. ncbi Liver resection or combined chemoembolization and radiofrequency ablation improve survival in patients with hepatocellular carcinoma
    Thomas Helmberger
    Department of Radiology, Klinikum Schleswig Holstein, University of Lubeck, Lubeck, Germany
    Digestion 75:104-12. 2007
  3. ncbi Systematic review of randomized trials for unresectable hepatocellular carcinoma: Chemoembolization improves survival
    Josep M Llovet
    Barcelona Clinic Liver Cancer Group, Liver Unit, Digestive Disease Institut, Institut d Investigacions Biomediques August Pi i Sunyer, Hospital Clinic, Catalonia, Spain
    Hepatology 37:429-42. 2003
  4. ncbi Randomized controlled trial of transarterial lipiodol chemoembolization for unresectable hepatocellular carcinoma
    Chung Mau Lo
    Center for the Study of Liver Disease, University of Hong Kong Medical Center, Queen Mary Hospital, Hong Kong, China
    Hepatology 35:1164-71. 2002
  5. ncbi Arterial embolisation or chemoembolisation versus symptomatic treatment in patients with unresectable hepatocellular carcinoma: a randomised controlled trial
    Josep M Llovet
    Liver Unit, Digestive Disease Institute, Hospital Clinic, University of Barcelona, Barcelona, Spain
    Lancet 359:1734-9. 2002
  6. ncbi Transarterial chemoembolization for unresectable hepatocellular carcinoma: meta-analysis of randomized controlled trials
    Calogero Cammà
    National Council of Research, Istituto Metodologie Diagnostiche Avanzate, Palermo, Italy
    Radiology 224:47-54. 2002
  7. ncbi Chemoembolization for hepatocellular carcinoma
    Jordi Bruix
    BCLC Group, Liver Unit, IDIBAPS, Hospital Clinic, University of Barcelona, Villarroel 170, 08036 Barcelona, Spain
    Gastroenterology 127:S179-88. 2004
  8. ncbi Evaluation of responses to chemoembolization in patients with unresectable hepatocellular carcinoma
    Osama M Ebied
    Department of Radiology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Cancer 97:1042-50. 2003
  9. ncbi Predisposing factors of bile duct injury after transcatheter arterial chemoembolization (TACE) for hepatic malignancy
    Jeong Sik Yu
    Department of Diagnostic Radiology and Research Institute of Radiological Science, Yonsei University College of Medicine, Yongdong Severance Hospital, 146 92 Dogok dong, Gangnam Gu, Seoul 135 270, South Korea
    Cardiovasc Intervent Radiol 25:270-4. 2002
  10. ncbi Radiation therapy for hepatocellular carcinoma: from palliation to cure
    Maria A Hawkins
    Department of Radiation Oncology, Princess Margaret Hospital, University of Toronto, Toronto, Ontario, Canada
    Cancer 106:1653-63. 2006

Detail Information

Publications221 found, 100 shown here

  1. ncbi Usefulness of cone-beam volume CT with flat panel detectors in conjunction with catheter angiography for transcatheter arterial embolization
    Shingo Kakeda
    Department of Radiology, University of Occupational and Environmental Health School of Medicine, 1 1 Iseigaoka, Yahatanishi ku, Kitakyushu 807 8555, Japan
    J Vasc Interv Radiol 18:1508-16. 2007
    ....
  2. ncbi Liver resection or combined chemoembolization and radiofrequency ablation improve survival in patients with hepatocellular carcinoma
    Thomas Helmberger
    Department of Radiology, Klinikum Schleswig Holstein, University of Lubeck, Lubeck, Germany
    Digestion 75:104-12. 2007
    ..To evaluate the long-term outcome of surgical and non-surgical local treatments of patients with hepatocellular carcinoma (HCC)...
  3. ncbi Systematic review of randomized trials for unresectable hepatocellular carcinoma: Chemoembolization improves survival
    Josep M Llovet
    Barcelona Clinic Liver Cancer Group, Liver Unit, Digestive Disease Institut, Institut d Investigacions Biomediques August Pi i Sunyer, Hospital Clinic, Catalonia, Spain
    Hepatology 37:429-42. 2003
    ..In conclusion, chemoembolization improves survival of patients with unresectable HCC and may become the standard treatment. Treatment with tamoxifen does not modify the survival of patients with advanced disease...
  4. ncbi Randomized controlled trial of transarterial lipiodol chemoembolization for unresectable hepatocellular carcinoma
    Chung Mau Lo
    Center for the Study of Liver Disease, University of Hong Kong Medical Center, Queen Mary Hospital, Hong Kong, China
    Hepatology 35:1164-71. 2002
    ..In conclusion, in Asian patients with unresectable hepatocellular carcinoma, transarterial Lipiodol chemoembolization significantly improves survival and is an effective form of treatment...
  5. ncbi Arterial embolisation or chemoembolisation versus symptomatic treatment in patients with unresectable hepatocellular carcinoma: a randomised controlled trial
    Josep M Llovet
    Liver Unit, Digestive Disease Institute, Hospital Clinic, University of Barcelona, Barcelona, Spain
    Lancet 359:1734-9. 2002
    ..There is no standard treatment for unresectable hepatocellular carcinoma. Arterial embolisation is widely used, but evidence of survival benefits is lacking...
  6. ncbi Transarterial chemoembolization for unresectable hepatocellular carcinoma: meta-analysis of randomized controlled trials
    Calogero Cammà
    National Council of Research, Istituto Metodologie Diagnostiche Avanzate, Palermo, Italy
    Radiology 224:47-54. 2002
    ..To review the available evidence of chemoembolization for unresectable hepatocellular carcinoma (HCC)...
  7. ncbi Chemoembolization for hepatocellular carcinoma
    Jordi Bruix
    BCLC Group, Liver Unit, IDIBAPS, Hospital Clinic, University of Barcelona, Villarroel 170, 08036 Barcelona, Spain
    Gastroenterology 127:S179-88. 2004
    ..The analysis of efficacy in these trials should be adjusted for prognostic factors, such as the presence of symptoms, Child-Pugh class, and segmental vascular invasion...
  8. ncbi Evaluation of responses to chemoembolization in patients with unresectable hepatocellular carcinoma
    Osama M Ebied
    Department of Radiology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Cancer 97:1042-50. 2003
    ....
  9. ncbi Predisposing factors of bile duct injury after transcatheter arterial chemoembolization (TACE) for hepatic malignancy
    Jeong Sik Yu
    Department of Diagnostic Radiology and Research Institute of Radiological Science, Yonsei University College of Medicine, Yongdong Severance Hospital, 146 92 Dogok dong, Gangnam Gu, Seoul 135 270, South Korea
    Cardiovasc Intervent Radiol 25:270-4. 2002
    ..05). It was concluded that the chance of bile duct injury after TACE is increased in non-cirrhotic livers with good liver profile and to the more selective embolization of distal arterial branches...
  10. ncbi Radiation therapy for hepatocellular carcinoma: from palliation to cure
    Maria A Hawkins
    Department of Radiation Oncology, Princess Margaret Hospital, University of Toronto, Toronto, Ontario, Canada
    Cancer 106:1653-63. 2006
    ..3 months to 9.7 months. Although outcomes after high-dose conformal RT for liver-confined HCC were excellent, the potential survival benefit of RT should be tested in randomized controlled trials that require international collaboration...
  11. ncbi Colorectal liver metastases: regional chemotherapy via transarterial chemoembolization (TACE) and hepatic chemoperfusion: an update
    Thomas J Vogl
    Institute for Diagnostic and Interventional Radiology, Johann Wolfgang Goethe University Clinic, Theodor Stern Kai 7, 60590, Frankfurt am Main, Germany
    Eur Radiol 17:1025-34. 2007
    ..The median survival ranged from 9 to 62 months and the morphological response ranged from 14 to 76%. Technical aspects, results, and complications of this modality will be demonstrated with a detailed analysis and comments...
  12. ncbi Safety and efficacy of transarterial chemoembolization in patients with unresectable hepatocellular carcinoma and portal vein thrombosis
    Christos S Georgiades
    Russell H Morgan Department of Radiology and Radiological Sciences, Johns Hopkins Hospital, 600 North Wolfe Street, Blalock 545, Baltimore, Maryland 21287, USA
    J Vasc Interv Radiol 16:1653-9. 2005
    ..The purpose of our study was to establish the safety of TACE in such patients and identify key prognostic factors and survival...
  13. ncbi Hepatic arterial chemoembolization in patients with liver metastases of endocrine tumors. A prospective phase II study in 24 patients
    P Ruszniewski
    Department of Gastroenterology, Hopital Bichat, Paris, France
    Cancer 71:2624-30. 1993
    ..Liver metastases of endocrine tumors are of major prognostic significance. The various therapeutic approaches have given disappointing results; however, locoregional treatment has allowed transient control of hepatic tumor growth...
  14. ncbi Pharmacokinetic and safety study of doxorubicin-eluting beads in a porcine model of hepatic arterial embolization
    Andrew L Lewis
    Drug Delivery Division, Biocompatibles UK Ltd, Farnham Business Park, Weydon Lane, Farnham, Surrey, GU9 8QL, United Kingdom
    J Vasc Interv Radiol 17:1335-43. 2006
    ..To present the pathologic and pharmacokinetic findings from hepatic embolization in a porcine model comparing doxorubicin-eluting beads with bland embolization and to correlate these findings with in vitro release kinetics...
  15. ncbi Drop-out rates of patients with hepatocellular cancer listed for liver transplantation: outcome with chemoembolization
    Yamini K Maddala
    Mayo Clinic and Foundation, 200 First Street SW, Rochester, MN 55905, USA
    Liver Transpl 10:449-55. 2004
    ..those who dropped out. In conclusion, neoadjuvant chemoembolization for patients with HCC has a drop-out rate of 15% over 6 months...
  16. ncbi Chemoembolization of hepatocellular carcinoma with drug eluting beads: efficacy and doxorubicin pharmacokinetics
    Maria Varela
    Liver Unit, IMDM, Barcelona Clinic Liver Cancer BCLC Group, Hospital Clinic, CIBER HEPAD, University of Barcelona, Institut d Investigacions Biomediques August Pi i Sunyer, IDIBAPS, Barcelona, Spain
    J Hepatol 46:474-81. 2007
    ..This study assesses the safety, pharmacokinetics and efficacy of transarterial chemoembolization using drug eluting beads (DEB), an embolizing device that slowly releases chemotherapy to decrease systemic toxicity...
  17. ncbi Intrahepatic biloma formation (bile duct necrosis) after transcatheter arterial chemoembolization
    Ichiro Sakamoto
    Department of Radiology, Nagasaki University School of Medicine, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    AJR Am J Roentgenol 181:79-87. 2003
    ....
  18. ncbi Local radiotherapy with or without transcatheter arterial chemoembolization for patients with unresectable hepatocellular carcinoma
    J C Cheng
    Departments of Department ofRadiation Oncology, Koo Foundation Sun Yat Sen Cancer Center, Taipei, Taiwan
    Int J Radiat Oncol Biol Phys 47:435-42. 2000
    ....
  19. ncbi Bile duct injuries leading to portal vein obliteration after transcatheter arterial chemoembolization in the liver: CT findings and initial observations
    J S Yu
    Department of Diagnostic Radiology and the Research Institute of Radiological Science, Yonsei University College of Medicine, Yongdong Severance Hospital, 146 92 Dogok dong, Gangnam Gu, Seoul 135 270, South Korea
    Radiology 221:429-36. 2001
    ....
  20. ncbi Prognostic factors for chemoembolization in liver metastasis from endocrine tumors
    A Roche
    Department of Interventional Radiology, Institut Gustave Roussy, Villejuif Cedex, France
    Hepatogastroenterology 51:1751-6. 2004
    ..The aims of this study were to assess response rates, evaluate side effects and determine prognostic factors for both response and toxicity in patients with liver metastasis from endocrine tumors treated with chemoembolization...
  21. ncbi Risk factors for liver abscess formation after hepatic chemoembolization
    W Kim
    Division of Interventional Radiology, University of Pennsylvania School of Medicine, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA
    J Vasc Interv Radiol 12:965-8. 2001
    ..The prophylaxis regimen used failed to prevent abscess formation in patients with earlier bilioenteric anastomosis...
  22. ncbi Liver abscess formation after transarterial chemoembolization for malignant hepatic tumor
    Shao Feng Huang
    Division of Gastroenterology, Department of Internal Medicine, Taichung Veterans General Hospital, No 160, Sec 3, Chung Kang Rd, Taichung, 40705, Taiwan
    Hepatogastroenterology 50:1115-8. 2003
    ..To study and review the clinical manifestations, microbiology, comorbidity, and diagnosis of liver abscess after transarterial chemoembolization for malignant hepatic tumor...
  23. ncbi Extrahepatic collateral supply of hepatocellular carcinoma by the intercostal arteries
    Sung Il Park
    Department of Diagnostic Radiology, Soonchunhyang University Chonan Hospital, Chonan, South Korea
    J Vasc Interv Radiol 14:461-8. 2003
    ....
  24. ncbi Preoperative transcatheter arterial chemoembolization reduces long-term survival rate after hepatic resection for resectable hepatocellular carcinoma
    A Sasaki
    Department of Surgery I, Oita University Faculty of Medicine, 1 1 Hasama machi, Yufu, Oita 879 5593, Japan
    Eur J Surg Oncol 32:773-9. 2006
    ....
  25. ncbi Three-dimensional conformal radiotherapy for portal vein thrombosis of hepatocellular carcinoma
    Dae Yong Kim
    Research Institute and Hospital, National Cancer Center, Gyeonggi, Korea
    Cancer 103:2419-26. 2005
    ..The authors evaluated the impact of radiotherapy (RT) for PVT of HCC and analyzed the dose-response relation between RT and PVT...
  26. pmc Local recurrence of hepatocellular carcinoma after segmental transarterial chemoembolization: risk estimates based on multiple prognostic factors
    Seung Hyun Park
    Department of Radiology, Seoul Veterans Hospital, Gangdong gu, Seoul, Korea
    Korean J Radiol 8:111-9. 2007
    ..To determine the prognostic factors for local recurrence of nodular hepatocellular carcinoma after segmental transarterial chemoembolization...
  27. ncbi Biliary migration of hepatocellular carcinoma fragment after transcatheter arterial chemoembolization therapy
    L Spahr
    Department of Gastroenterology and Hepatology, University Hospital, Geneva, Switzerland
    Eur J Gastroenterol Hepatol 12:243-4. 2000
    ..We discuss the causes of obstructive jaundice in the setting of hepatocellular carcinoma as well as in the specific situation of transcatheter arterial chemoembolization therapy...
  28. ncbi Chemoembolization followed by liver transplantation for hepatocellular carcinoma impedes tumor progression while on the waiting list and leads to excellent outcome
    Ivo W Graziadei
    Department of Gastroenterology and Hepatology, University Hospitals Innsbruck, Austria
    Liver Transpl 9:557-63. 2003
    ..Furthermore, TACE is highly efficacious in preventing tumor progression while waiting for OLT. Although TACE reduced tumor preoperatively, it failed to show a beneficial effect on patient survival in advanced-stage HCCs...
  29. ncbi Hepatocellular carcinoma: the role of the North American GI Steering Committee Hepatobiliary Task Force and the advent of effective drug therapy
    BERT H O'NEIL
    University of North Carolina Lineberger Comprehensive Cancer Center, Chapel Hill, NC 27599, USA
    Oncologist 12:1425-32. 2007
    ..This article briefly discusses the management of earlier stage HCC, then focuses on newer agents with promise, particularly sorafenib, a drug that appears to be the new standard of care for advanced disease...
  30. ncbi Factors predictive of 5-year survival after transarterial chemoembolization for inoperable hepatocellular carcinoma
    C B O'Suilleabhain
    Department of Surgery, Centre for the Study of Liver Disease, University of Hong Kong Medical Centre, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong, China
    Br J Surg 90:325-31. 2003
    ..Transarterial chemoembolization (TACE) is widely used for unresectable hepatocellular carcinoma (HCC), but the long-term survival benefit remains unclear...
  31. ncbi Recurrences of hepatocellular carcinoma following initial remission by transcatheter arterial chemoembolization
    Jae Kyun Lee
    Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea
    J Gastroenterol Hepatol 17:52-8. 2002
    ....
  32. ncbi Ultraselective transcatheter arterial chemoembolization with a 2-f tip microcatheter for small hepatocellular carcinomas: relationship between local tumor recurrence and visualization of the portal vein with iodized oil
    Shiro Miyayama
    Department of Diagnostic Radiology, Fukuiken Saiseikai Hospital, 7 1 Funabashi, Wadanaka cho, Fukui 918 8503, Japan
    J Vasc Interv Radiol 18:365-76. 2007
    ..To retrospectively evaluate the relationship between local tumor recurrence and iodized oil deposition in the portal vein by using ultraselective transcatheter arterial chemoembolization (TACE) for small hepatocellular carcinoma...
  33. ncbi Transarterial chemoembolization of advanced liver metastases of neuroendocrine tumors--a retrospective single-center analysis
    O Kress
    Department of Diagnostic Radiology, Philipps University Hospital, Marburg, Germany
    Digestion 68:94-101. 2003
    ..Transcatheter arterial chemoembolization (TACE) is thought to be an effective symptomatic and antiproliferative treatment in patients with otherwise progressive disease...
  34. ncbi Chemoembolization combined with radiofrequency ablation for patients with hepatocellular carcinoma larger than 3 cm: a randomized controlled trial
    Bao Quan Cheng
    Department of Gastroenterology, Qilu Hospital School of Medicine, Jinan, China
    JAMA 299:1669-77. 2008
    ..Transarterial chemoembolization (TACE) combined with radiofrequency ablation (RFA) therapy has been used for patients with large hepatocellular carcinoma tumors, but the survival benefits of combined treatment are not known...
  35. ncbi Ischemic bile duct injury as a serious complication after transarterial chemoembolization in patients with hepatocellular carcinoma
    H K Kim
    Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea
    J Clin Gastroenterol 32:423-7. 2001
    ..We suggest that adjustments in the amounts of iodized oil or gelatin sponge particles and in the sites of embolization may reduce ischemic biliary injuries after TACE...
  36. pmc Transcatheter arterial chemoembolization of hepatocellular carcinoma: prevalence and causative factors of extrahepatic collateral arteries in 479 patients
    Jin Wook Chung
    Department of Radiology, Seoul National University Hospital, Chongno Gu, Seoul, Korea
    Korean J Radiol 7:257-66. 2006
    ..We wanted to investigate the prevalence and causative factors of extrahepatic arterial blood supply to hepatocellular carcinoma (HCC) at its initial presentation and during chemoembolization...
  37. ncbi Transcatheter arterial chemoembolization in combination with radiotherapy for unresectable hepatocellular carcinoma: a systematic review and meta-analysis
    Mao Bin Meng
    Division of Thoracic Cancer, West China Hospital, West China School of Medicine, Sichuan University, 37 Guoxue Lane, Chengdu, China
    Radiother Oncol 92:184-94. 2009
    ....
  38. ncbi Recognizing extrahepatic collateral vessels that supply hepatocellular carcinoma to avoid complications of transcatheter arterial chemoembolization
    Hyo Cheol Kim
    Department of Radiology, Seoul National University College of Medicine, and the Institute of Radiation Medicine, Seoul National University Medical Research Center, Seoul National University Hospital, 28 Yongon Dong, Chongno Gu, Seoul 110 744, Korea
    Radiographics 25:S25-39. 2005
    ..When both the hepatic artery and extrahepatic collateral vessels supply a tumor, additional extrahepatic collateral vessel chemoembolization should be attempted to increase the therapeutic efficacy of TACE for hepatocellular carcinoma...
  39. ncbi Radiation therapy in combination with transcatheter arterial chemoembolization for hepatocellular carcinoma with extensive portal vein involvement
    J Tazawa
    Departments of Internal Medicine and Radiology, Tsuchiura Kyodo General Hospital, Ibaraki, Japan
    J Gastroenterol Hepatol 16:660-5. 2001
    ....
  40. ncbi Transcatheter arterial chemoembolization for unresectable hepatocellular carcinoma fed by the cystic artery
    Shiro Miyayama
    Department of Diagnostic Radiology, Fukuiken Saiseikai Hospital, 7 1, Funabashi, Wadanaka cho, Fukui 918 8503, Japan
    J Vasc Interv Radiol 14:1155-61. 2003
    ..To evaluate the safety, technical success rate, and effectiveness of transcatheter arterial chemoembolization (TACE) for unresectable hepatocellular carcinoma (HCC) fed by the cystic artery...
  41. ncbi Long-term follow-up of hepatic arterial chemoembolization with cisplatin suspended in iodized oil for hepatocellular carcinoma
    Seishi Maeda
    Third Department of Internal Medicine, Kumamoto University School of Medicine, 1 1, Honjo 1 chome, Kumamoto 860 8556, Japan
    Hepatogastroenterology 50:809-13. 2003
    ..We evaluated the results of the long-term follow-up of lipiodol-cisplatin suspension therapy and the augmentation of its anti-cancer effect when in combination with transcatheter arterial embolization...
  42. ncbi Trans-catheter arterial chemoembolization as first-line treatment for hepatic metastases from endocrine tumors
    Alain Roche
    Service de Radiologie Interventionnelle, Institut Gustave Roussy, rue Camille Desmoulins 39, 94805 Villejuif Cedex, France
    Eur Radiol 13:136-40. 2003
    ..Long-term palliation is possible in unresectable liver metastases from digestive neuroendocrine tumors with a few sessions of TACE as first-line and eventually exclusive treatment...
  43. ncbi Impact of pretransplantation transarterial chemoembolization on survival and recurrence after liver transplantation for hepatocellular carcinoma
    Thomas Decaens
    Service d hépatologie et de gastroentérologie, AP HP, Hopital Henri Mondor, 512 Avenue du Maréchal de Lattre de Tassigny, 94000 Creteil, France
    Liver Transpl 11:767-75. 2005
    ..2%, compared with 54.2% among their matched controls (P = 0.9). In conclusion, with a mean waiting period of 4.2 months and 1 TACE procedure, pre-LT TACE does not influence post-LT overall survival and disease-free survival...
  44. ncbi Arterial chemoembolization before liver transplantation in patients with hepatocellular carcinoma: marked tumor necrosis, but no survival benefit?
    K J Oldhafer
    Klinik fur Abdominal und Transplantationschirurgie, Medizinische Hochschule Hannover, Germany
    J Hepatol 29:953-9. 1998
    ..This study aimed to investigate whether preoperative chemoembolization not only induces marked tumor necrosis but also has a survival benefit...
  45. ncbi Is preoperative transarterial chemoembolization needed for a resectable hepatocellular carcinoma?
    Gi Hong Choi
    Department of Surgery, Yonsei University College of Medicine, Seodaemun Ku, Seoul, Korea
    World J Surg 31:2370-7. 2007
    ..Whether preoperative transarterial chemoembolization (TACE) has the therapeutic benefits in patients with resectable hepatocellular carcinoma (HCC) remains uncertain...
  46. ncbi Prospective trial of combined transcatheter arterial chemoembolization and three-dimensional conformal radiotherapy for portal vein tumor thrombus in patients with unresectable hepatocellular carcinoma
    Kazunari Yamada
    Department of Radiology, Kobe University Graduate School of Medicine, Kobe, Japan
    Int J Radiat Oncol Biol Phys 57:113-9. 2003
    ..The aim of the present study was to investigate the efficacy and toxicity of this trial regime...
  47. pmc Multivariate analysis of the predictors of survival for patients with hepatocellular carcinoma undergoing transarterial chemoembolization: focusing on superselective chemoembolization
    Suk Kyeong Ji
    Department of Radiology, Seoul Veterans Hospital, Seoul, Korea
    Korean J Radiol 9:534-40. 2008
    ..We tried to analyze the potential factors of disease-free survival for these patients, including the performance of selective TACE...
  48. ncbi Hepatic artery embolization and chemoembolization for treatment of patients with metastatic carcinoid tumors: the M.D. Anderson experience
    Sanjay Gupta
    Department of Diagnostic Radiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer J 9:261-7. 2003
    ....
  49. ncbi Hypofractionated three-dimensional conformal radiation therapy for primary liver carcinoma
    Shi xiong Liang
    Department of Radiation Oncology, Cancer Hospital, Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, China
    Cancer 103:2181-8. 2005
    ....
  50. ncbi Local radiotherapy as a complement to incomplete transcatheter arterial chemoembolization in locally advanced hepatocellular carcinoma
    Su Jung Shim
    Department of Radiation Oncology, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Korea
    Liver Int 25:1189-96. 2005
    ....
  51. ncbi The impact of pre-operative loco-regional therapy on outcome after liver transplantation for hepatocellular carcinoma
    Francis Y Yao
    Department of Medicine, University of California, San Francisco, CA, USA
    Am J Transplant 5:795-804. 2005
    ....
  52. ncbi Doxorubicin eluting beads - 1: effects of drug loading on bead characteristics and drug distribution
    Andrew L Lewis
    Drug Delivery Division, Biocompatibles UK Ltd, Farnham Business Park, Farnham, Surrey, UK
    J Mater Sci Mater Med 18:1691-9. 2007
    ....
  53. pmc Depiction of viable tumor in hepatocellular carcinoma treated with transarterial chemoembolization: multiphasic helical CT with review of the previous serial CT images
    Kyung Mi Jang
    Department of Radiology and Center Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    Korean J Radiol 6:153-60. 2005
    ....
  54. ncbi Combining systemic chemotherapy with chemoembolization in the treatment of unresectable hepatic metastases from colorectal cancer
    Yau Tong You
    Division of Colon and Rectal Surgery, Chang Gung Memorial Hospital, 5, Fu Hsing St, Kuei Shan, Tao Yuan, Taiwan
    Int J Colorectal Dis 21:33-7. 2006
    ..Most of the patients (73%) died of hepatic failure, while the second largest group died of abdominal carcinomatosis. In conclusion, the results of this study are of sufficient interest to justify future randomized trials...
  55. ncbi Outcome of transarterial chemoembolization in patients with inoperable hepatocellular carcinoma eligible for radiofrequency ablation
    Mike S L Liem
    Dutch Cancer Society, Queen Wilhelmina Fund, Amsterdam, The Netherlands
    World J Gastroenterol 11:4465-71. 2005
    ..To evaluate the outcome of transarterial chemoembolization (TACE) in patients with unresectable hepatocellular carcinoma (HCC) <5 cm in diameter eligible for radiofrequency ablation (RFA)...
  56. ncbi Irinotecan drug eluting beads for use in chemoembolization: in vitro and in vivo evaluation of drug release properties
    Rachel R Taylor
    Biocompatibles UK Ltd, Farnham Business Park, Weydon Lane, Farnham, Surrey GU9 8QL, UK
    Eur J Pharm Sci 30:7-14. 2007
    ..The in vivo data were shown to correlate well with the in vitro release measured using a T-apparatus model of embolization...
  57. ncbi Transarterial therapy for hepatocellular carcinoma: which technique is more effective? A systematic review of cohort and randomized studies
    Laura Marelli
    Liver Transplantation and Hepatobiliary Medicine Unit, Royal Free Hospital, Pond Street, NW3 2QG, London, UK
    Cardiovasc Intervent Radiol 30:6-25. 2007
    ..Chemoembolization (TACE) improves survival in cirrhotic patients with hepatocellular carcinoma (HCC). The optimal schedule, or whether embolization (TAE) alone gives the same survival advantage, is not known...
  58. ncbi Combined therapy of transcatheter arterial chemoembolisation and three-dimensional conformal radiotherapy for hepatocellular carcinoma
    Z H Zhou
    Department of Integrative Chinese and Western Medicine, Fudan University Cancer Hospital, Shanghai 200032, China
    Br J Radiol 80:194-201. 2007
    ..The combined modality of TACE and 3DCRT was tolerable for the majority of HCC patients, resulted in good outcome and warrants for further prospective trial...
  59. pmc Risk factors for local tumor recurrence after segmental transarterial chemoembolization for hepatocellular carcinoma: the importance of tumor located in the segmental border zone
    Yun Ku Cho
    Department of Radiology, Seoul Veterans Hospital, Gangdong gu, Seoul, Korea
    Korean J Radiol 7:267-74. 2006
    ..We wanted to evaluate whether tumors located in a segmental border zone are predisposed to local recurrence after performing segmental transarterial chemoembolization for hepatocellular carcinoma...
  60. ncbi DC bead: in vitro characterization of a drug-delivery device for transarterial chemoembolization
    Andrew L Lewis
    Drug Delivery Division, School of Pharmacy and Biomolecular Sciences, University of Brighton, East Sussex, United Kingdom
    J Vasc Interv Radiol 17:335-42. 2006
    ..The purpose of this investigation is to present the in vitro characterization and detailed drug-loading procedure for DC Bead, a microsphere product that can be loaded with chemotherapeutic agents for embolization...
  61. pmc The current practice of transarterial chemoembolization for the treatment of hepatocellular carcinoma
    Sung Wook Shin
    Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    Korean J Radiol 10:425-34. 2009
    ..In this review, the basic principles, technical issues and complications of TACE are reviewed and recent advancement in TACE technique and clinical applicability are briefed...
  62. ncbi Sloughing of intraductal tumor thrombus of hepatocellular carcinoma after transcatheter chemoembolization causing obstructive jaundice and acute pancreatitis
    Takao Hiraki
    J Vasc Interv Radiol 17:583-5. 2006
  63. ncbi Nonsurgical approaches to colorectal cancer
    David P Ryan
    Tucker Gosnell Gastrointestinal Cancer Center, Massachusetts General Hospital Cancer Center, Boston, Massachusetts 02114, USA
    Oncologist 11:999-1002. 2006
    ..At the very least, it is clear that locoregional approaches to debulking tumors are feasible and that their combination with systemic chemotherapy should be investigated...
  64. ncbi Outcome of regional and local ablative therapies for hepatocellular carcinoma: a collective review
    M C Jansen
    Department of Surgery, Academic Medical Center, Meibergdreef 9, P O Box 22660, 1105 AZ Amsterdam, The Netherlands
    Eur J Surg Oncol 31:331-47. 2005
    ..It would not be ethical to compare resection with ablation in patients well enough to undergo major surgery. Therefore, hepatic resection and hepatic transplantation remain the only curative treatment options for HCC...
  65. ncbi A phase I/II trial of chemoembolization for hepatocellular carcinoma using a novel intra-arterial drug-eluting bead
    Ronnie T P Poon
    Department of Surgery, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    Clin Gastroenterol Hepatol 5:1100-8. 2007
    ..To assess the safety and efficacy of transarterial chemoembolization (TACE) using doxorubicin-eluting beads (DEB) for hepatocellular carcinoma (HCC)...
  66. ncbi Liver abscess after transcatheter oily chemoembolization for hepatic tumors: incidence, predisposing factors, and clinical outcome
    S Y Song
    Department of Radiology and Institute of Radiation Medicine, Seoul National University College of Medicine, and Clinical Research Institute, Seoul National University Hospital, Korea
    J Vasc Interv Radiol 12:313-20. 2001
    ..Postembolic liver abscess could be effectively managed with percutaneous catheter drainage...
  67. ncbi Therapeutic efficacy of transcatheter arterial chemoembolization as compared with hepatic resection in hepatocellular carcinoma patients with compensated liver function in a hepatitis B virus-endemic area: a prospective cohort study
    Hyo Suk Lee
    Department of Internal Medicine, Liver Research Institute, Seoul National University Hospital, Chongno Gu, Korea
    J Clin Oncol 20:4459-65. 2002
    ....
  68. ncbi Design and endpoints of clinical trials in hepatocellular carcinoma
    Josep M Llovet
    HCC Translational Research Lab, Barcelona Clinic Liver Cancer Group, Liver Unit, Hospital Clinic, CIBERehd, Institute for Biomedical Investigations August Pi Sunyer, Villarroel 170, 08036 Barcelona, Catalonia, Spain
    J Natl Cancer Inst 100:698-711. 2008
    ..These surrogate markers may help to enrich study populations and maximize the cost-benefit ratio of trial execution. Design and conduct of phase 3 trials should be coordinated by centers with appropriate expertise in HCC...
  69. ncbi Multimicrobial sepsis including Clostridium perfringens after chemoembolization of a single liver metastasis from common bile duct cancer
    F Eckel
    Department of Medicine II, Technical University of Munich, Klinikum rechts der Isar, Munich, Germany
    Digestion 62:208-12. 2000
    ....
  70. ncbi Angiographic subsegmentectomy for the treatment of patients with small hepatocellular carcinoma
    Shozo Iwamoto
    Iwamoto Hospital, Kitakyushu, Japan
    Cancer 97:1051-6. 2003
    ..The authors recently developed a new technique called angiographic subsegmentectomy for the treatment of patients with small HCC...
  71. ncbi Evaluation of irinotecan drug-eluting beads: a new drug-device combination product for the chemoembolization of hepatic metastases
    Y Tang
    Biocompatibles UK Ltd, Farnham, Surrey, United Kingdom
    J Control Release 116:e55-6. 2006
  72. ncbi Meta-analysis of transarterial embolization in patients with unresectable hepatocellular carcinoma
    Robert P Myers
    Radiology 227:611-2; author reply 612-3. 2003
  73. ncbi Comparison between chemoembolization combined with radiotherapy and chemoembolization alone for large hepatocellular carcinoma
    Wei jian Guo
    Department of Oncology, Xinhua Hospital of Shanghai Second Medical University, 1665 Kongjiang Road, Shanghai 200092, China
    World J Gastroenterol 9:1697-701. 2003
    ..To investigate the efficacy of transcatheter arterial chemoembolization (TACE) combined with radiotherapy for unresectable large hepatocellular carcinoma (HCC)...
  74. ncbi Chemoembolization of hepatocellular carcinomas. A study of the biodistribution and pharmacokinetics of doxorubicin
    J L Raoul
    Department of Hepatogastroenterology, Hopital Pontchaillou, Rennes, France
    Cancer 70:585-90. 1992
    ....
  75. ncbi [Investigation of bile duct injury after transcatheter arterial chemoembolization]
    Mao Qiang Wang
    Department of Interventional Radiology, Chinese PLA General Hospital, Beijing 100853, China
    Zhonghua Zhong Liu Za Zhi 27:609-12. 2005
    ..To investigate the image findings of bile duct injury after transcatheter arterial chemoembolization (TACE) for hepatic malignancy...
  76. ncbi A new chemoembolization protocol in refractory liver metastasis of colorectal cancer--a feasibility study
    W Voigt
    Abteilung Hämatologie Onkologie, Martin Luther Universitat, Halle Wittenberg, Halle Saale, Germany
    Onkologie 25:158-64. 2002
    ..At the time of treatment, patients had exclusively or dominantly liver metastasis of CRC...
  77. ncbi Prognostic prediction and treatment strategy in hepatocellular carcinoma
    Jordi Bruix
    Barcelona Clinic Liver Cancer BCLC Group, Liver Unit, Digestive Disease Institute, Hospital Clinic i Provincial, Villaroel 170, 08036 Barcelona, Catalonia, Spain
    Hepatology 35:519-24. 2002
  78. ncbi The impact of hepatitis B viral load on recurrence after complete necrosis in patients with hepatocellular carcinoma who receive transarterial chemolipiodolization: implications for viral suppression to reduce the risk of cancer recurrence
    Jeong Won Jang
    Department of Internal Medicine, College of Medicine, World Health Organization Collaborating Center on Viral Hepatitis, The Catholic University of Korea, Seoul, Korea
    Cancer 110:1760-7. 2007
    ..The objective of this study was to identify the potential relation between viral load and HCC recurrence in patients undergoing transarterial chemolipiodolization...
  79. pmc Hepatic arterioportal shunts: dynamic CT and MR features
    Byung Ihn Choi
    Department of Radiology, College of Medicine, Seoul National University Hospital, 28 Yongon Dong, Chongno Gu, Seoul 110 744, Korea
    Korean J Radiol 3:1-15. 2002
    ..Familiarity with the pathophysiology of arterioportal shunt also allows investigation of the hepatic hemodynamic changes occurring in various hepatic diseases...
  80. ncbi A prospective study regarding the complications of transcatheter intraarterial lipiodol chemoembolization in patients with hepatocellular carcinoma
    Annie O Chan
    Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong
    Cancer 94:1747-52. 2002
    ..Transcatheter intraarterial lipiodol chemoembolization (TACE) has been reported to be one of the most effective palliative measures for HCC. However, its severe side effects continue to make its use controversial...
  81. ncbi Hepatic artery chemoembolization
    Kevin L Sullivan
    Department of Radiology, Division of Cardiovascular and Interventional Radiology, Thomas Jefferson University Hospital, Philadelphia, PA 19107, USA
    Semin Oncol 29:145-51. 2002
    ..Efficacy in other groups, such as patients with colorectal cancer metastatic to the liver, is less well established, but a recently initiated multicenter trial may resolve this issue...
  82. ncbi Randomized phase II trial of embolization therapy versus chemoembolization therapy in previously treated patients with colorectal carcinoma metastatic to the liver
    Huda S Salman
    Department of Radiology, Albert Einstein College of Medicine and the Albert Einstein Comprehensive Cancer Center, Bronx, NY, USA
    Clin Colorectal Cancer 2:173-9. 2002
    ..Embolization of the liver as second-line therapy in patients with liver-predominant metastases is safe and effective. Median survivals are comparable to other second-line therapies..
  83. ncbi Hepatic arterial and portal venous phase helical CT in patients treated with transcatheter arterial chemoembolization for hepatocellular carcinoma: added value of unenhanced images
    Hyo Cheol Kim
    Department of Radiology and Institute of Radiation Medicine, Seoul National University College of Medicine, Clinical Research Institute, Seoul National University Hospital, 28 Yongon Dong, Chongno Gu, Seoul 110 744, Korea
    Radiology 225:773-80. 2002
    ....
  84. ncbi Transcatheter arterial chemoembolization for hepatocellular carcinomas in patients with celiac axis occlusion
    Jong Won Kwon
    Department of Radiology, Seoul National University College of Medicine, Seoul, Korea
    J Vasc Interv Radiol 13:689-94. 2002
    ....
  85. ncbi [A case of infiltrative hepatocellular carcinoma with main portal vein tumor thrombosis successfully treated by transarterial chemoembolization]
    Sun Jung Myung
    Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea
    Korean J Hepatol 12:107-11. 2006
    ....
  86. ncbi Targeted transarterial oily chemoembolization for small foci of hepatocellular carcinoma using a unified helical CT and angiography system: analysis of factors affecting local recurrence and survival rates
    K Takayasu
    Department of Diagnostic Radiology, National Cancer Center Hospital, Tsukiji, Chuo-ku, Tokyo 104-0045, Japan
    AJR Am J Roentgenol 176:681-8. 2001
    ..Tumor size along with degree of intratumoral iodized oil deposition and tumor thrombus along with maximum tumor size were significant factors affecting local recurrence and survival rate, respectively...
  87. ncbi [Therapy of metastatic malignant uveal melanoma]
    A Jäckel
    Universitäts Hautklinik, Ruprecht Karls Universitat Heidelberg, Vossstrasse 2, 69115 Heideberg
    Hautarzt 52:98-103. 2001
    ..Following the characterisation of primary uveal melanoma, we summarize the results of different treatment protocols for metastatic disease and give an overview of new strategies...
  88. ncbi Ablative therapies for liver metastases of digestive endocrine tumours
    D O'Toole
    Medical Surgical Federation of Hepato Gastroenterology, Hôpital Beaujon and University of Paris VII, 100, Bd du Général Leclerc, Clichy 92110, France
    Endocr Relat Cancer 10:463-8. 2003
    ..The latter are usually important adjuncts to surgery and are usually reserved for limited disease...
  89. ncbi [Hepatic arterial infusion chemotherapy for advanced hepatocellular carcinoma providing a good QOL]
    Shinya Yamashita
    Dept of Surgery, Nishinomiya Municipal Central Hospital
    Gan To Kagaku Ryoho 33:1928-30. 2006
    ..An appetite loss (grade 2) appeared, but it could be well controlled. Serum AFP decreased again, up to 54 ng/ml. A good QOL was kept for about one year after the initiation of hepatic arterial infusion chemotherapy...
  90. ncbi [Three cases of hepatocellular carcinoma, over 3 cm in diameter, with liver cirrhosis treated with combination of radiofrequency ablation and continuous hepatic arterial infusion chemotherapy]
    Teijiro Hirashita
    Dept of Surgery, Sakai Hospital
    Gan To Kagaku Ryoho 34:1123-6. 2007
    ..It is suggested that combination therapy can be one of the treatments for hepatocellular carcinoma, over 3 cm in diameter,with liver cirrhosis...
  91. ncbi Successful treatment of large-size advanced hepatocellular carcinoma by transarterial chemoembolization followed by the combination therapy of percutaneous ethanol-lipiodol injection and radiofrequency ablation
    Kazutaka Kurokohchi
    Department of Gastroenterology and Neurology, Kagawa University School of Medicine, Ikenobe, Kagawa 761 0793, Japan
    Oncol Rep 16:1067-70. 2006
    ..PELI-RFA and PELI may be effective for the treatment of large-size HCC of patients with poor hepatic reserve...
  92. ncbi Early-stage hepatocellular carcinoma: radiofrequency ablation combined with chemoembolization versus hepatectomy
    Koichiro Yamakado
    Department of Radiology, Mie University School of Medicine, 2 174 Edobashi, Tsu, Mie 514 8507, Japan
    Radiology 247:260-6. 2008
    ..To retrospectively evaluate the long-term results of radiofrequency (RF) ablation combined with chemoembolization (combination therapy) as compared with hepatectomy for the treatment of early-stage hepatocellular carcinoma (HCC)...
  93. pmc Efficacy of transcatheter embolization/chemoembolization (TAE/TACE) for the treatment of single hepatocellular carcinoma
    Roberto Miraglia
    Istituto Mediterraneo Trapianti e Terapie ad Alta Specializzazione, University of Pittsburgh Medical Center, Italy
    World J Gastroenterol 13:2952-5. 2007
    ..To investigate the efficacy of transcatheter embolization/chemoembolization (TAE/TACE) in cirrhotic patients with single hepatocellular carcinoma (HCC) not suitable for surgical resection and percutaneous ablation therapy...
  94. ncbi Individualized treatment models based on blood supply characteristics in hepatocellular carcinoma using color Doppler hemodynamics
    Qin Si
    The 81st Hospital of People s Liberation Army of China, Nanjing, China
    Hepatogastroenterology 54:334-41. 2007
    ....
  95. doi Radiofrequency ablation combined with chemoembolization for early-stage hepatocellular carcinoma
    Yun Ku Cho
    Radiology 249:718-9; author reply 719. 2008
  96. ncbi Multicentre randomised phase III trial comparing Tamoxifen alone or with Transarterial Lipiodol Chemoembolisation for unresectable hepatocellular carcinoma in cirrhotic patients (Fédération Francophone de Cancérologie Digestive 9402)
    M Doffoel
    Service d Hepatogastroenterologie, Hopitaux Universitaires de Strasbourg, Strasbourg, France
    Eur J Cancer 44:528-38. 2008
    ..004) and Spitzer Index (P=.013) as shown by multivariable analysis. In conclusion, this study suggests that TACE improves neither the survival nor the quality of life in patients with HCC and cirrhosis...
  97. ncbi Survival rates according to the Cancer of the Liver Italian Program scores of 345 hepatocellular carcinoma patients after multimodality treatments during a 10-year period in a retrospective study
    Kentaro Yamagiwa
    Department of Surgery, Mie Prefectural Shima Hospital, Mie, Japan
    J Gastroenterol Hepatol 23:482-90. 2008
    ..This retrospective cohort study of HCC patients was conducted to assess the efficacy of treatment modalities according to the CLIP score...
  98. ncbi Iodized oil accumulation in hypervascular hepatocellular carcinoma after transcatheter arterial chemoembolization: comparison of imaging findings with CT during hepatic arteriography
    Takeshi Fujita
    Department of Radiology, Yamaguchi University School of Medicine, Minamikogushi, Ube, Yamaguchi, Japan
    J Vasc Interv Radiol 19:333-41. 2008
    ....
  99. ncbi Pilot study of combination therapy with transcatheter arterial infusion chemotherapy using iodized oil and percutaneous radiofrequency ablation during occlusion of hepatic blood flow for hepatocellular carcinoma
    Ryu Shiraishi
    Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan
    Am J Clin Oncol 31:311-6. 2008
    ..In this study, we evaluated the efficacy and safety of combination therapy with transcatheter arterial infusion chemotherapy (TAI) using iodized oil and balloon-occluded RF ablation in patients with hepatocellular carcinoma...
  100. ncbi Transcatheter arterial chemoembolization (TACE) with lipiodol to treat hepatocellular carcinoma: survey results from the TACE study group of Japan
    Mituo Satake
    Department of Diagnostic Radiology, National Cancer Center, 5 1 1 Tsukiji, Chuo Ku, Tokyo, 104 0045, Japan
    Cardiovasc Intervent Radiol 31:756-61. 2008
    ..In conclusion, this survey clarified that TACE using Lipiodol and anticancer agents is a popular option for HCC treatment in Japan...
  101. ncbi Angiographic evaluation of hepatic arterial damage after transarterial chemoembolization for hepatocellular carcinoma
    Noboru Maeda
    Department of Diagnostic and Interventional Radiology, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita 565 0871, Japan
    Radiat Med 26:206-12. 2008
    ..The aim of this study was to assess the incidence, degree, and predictors of hepatic arterial damage (HAD) after transarterial chemoembolization (TACE) for hepatocellular carcinoma (HCC)...

Research Grants8

  1. Therapy for Liver Cancer by Targeting Energy Metabolism
    Jean Francois Geschwind; Fiscal Year: 2007
    ..This translational study combining the use of radiological and basic science research tools is both necessary and fundamental to firmly lay the groundwork for clinical trials. ..
  2. HEPATITIS C VIRAL QUASISPECIES WITHIN THE LIVER
    Adrian Di Bisceglie; Fiscal Year: 2003
    ..These studies have great potential significance for understanding of viral clearance, development of persistent infection and for the development of a vaccine against HCV. ..
  3. Cytokine Inhibition in Hepatocellular Carcinoma
    Jonathan Schwartz; Fiscal Year: 2005
    ....
  4. REGULATION OF THE HUMAN INOS GENE IN SEPSIS AND TRAUMA
    David Geller; Fiscal Year: 2007
    ..abstract_text> ..
  5. Percutaneous MR Guided Creation of a Meso-Caval Shunt
    Aravind Arepally; Fiscal Year: 2008
    ....
  6. Hepatic Arterial Flouridine and IV Bevacizumab for Primary Hepatic Malignancy
    William Jarnagin; Fiscal Year: 2008
    ..Furthermore, several important clinical issues are addressed by the proposed correlative studies, the results of which would be of broad general interest in clinical oncology. [unreadable] [unreadable] [unreadable]..
  7. L-Arginine/NO in Liver Transplant Preservation Injury
    David Geller; Fiscal Year: 2008
    ..We expect these findings to have broad implications far beyond transplant preservation injury that may be applicable to any form of liver injury resulting in hepatocellular arginase release and arginine depletion. ..
  8. US Prostate Cancer Detection with Dutasteride Pretreatment
    Ethan Halpern; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..