rest

Summary

Summary: Freedom from activity.

Top Publications

  1. pmc A default mode of brain function
    M E Raichle
    Mallinckrodt Institute of Radiology and Departments of Neurology and Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 98:676-82. 2001
  2. pmc Functional connectivity in the resting brain: a network analysis of the default mode hypothesis
    Michael D Greicius
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, CA 94305 5719, USA
    Proc Natl Acad Sci U S A 100:253-8. 2003
  3. pmc Consistent resting-state networks across healthy subjects
    J S Damoiseaux
    Department of Neurology, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    Proc Natl Acad Sci U S A 103:13848-53. 2006
  4. pmc Resting-state functional connectivity in major depression: abnormally increased contributions from subgenual cingulate cortex and thalamus
    Michael D Greicius
    Department of Neurology and Neurological Sciences, Stanford University Medical Center, Stanford, California 94305 5235, USA
    Biol Psychiatry 62:429-37. 2007
  5. pmc The impact of global signal regression on resting state correlations: are anti-correlated networks introduced?
    Kevin Murphy
    Section on Functional Imaging Methods, National Institute of Mental Health, Bethesda, MD 20892 1148, USA
    Neuroimage 44:893-905. 2009
  6. ncbi Altered baseline brain activity in children with ADHD revealed by resting-state functional MRI
    Yu Feng Zang
    National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing, China
    Brain Dev 29:83-91. 2007
  7. pmc NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses
    Anita E Autry
    Department of Psychiatry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9111, USA
    Nature 475:91-5. 2011
  8. ncbi Frequencies contributing to functional connectivity in the cerebral cortex in "resting-state" data
    D Cordes
    Department of Medical Physics, University of Wisconsin at Madison, 1300 University Ave, 1530 MSC, Madison, WI 53706, USA
    AJNR Am J Neuroradiol 22:1326-33. 2001
  9. ncbi Reduced resting-state brain activity in the "default network" in normal aging
    J S Damoiseaux
    Department of Neurology, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    Cereb Cortex 18:1856-64. 2008
  10. pmc The global signal and observed anticorrelated resting state brain networks
    Michael D Fox
    Departments of Radiology, Washington University in St Louis, St Louis, Missouri, USA
    J Neurophysiol 101:3270-83. 2009

Detail Information

Publications375 found, 100 shown here

  1. pmc A default mode of brain function
    M E Raichle
    Mallinckrodt Institute of Radiology and Departments of Neurology and Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 98:676-82. 2001
    ..These decreases suggest the existence of an organized, baseline default mode of brain function that is suspended during specific goal-directed behaviors...
  2. pmc Functional connectivity in the resting brain: a network analysis of the default mode hypothesis
    Michael D Greicius
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, CA 94305 5719, USA
    Proc Natl Acad Sci U S A 100:253-8. 2003
    ..decreased activity during a cognitive (working memory) task, then examined their functional connectivity during rest. PCC was strongly coupled with vACC and several other brain regions implicated in the default mode network...
  3. pmc Consistent resting-state networks across healthy subjects
    J S Damoiseaux
    Department of Neurology, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    Proc Natl Acad Sci U S A 103:13848-53. 2006
    ..It has been suggested that fluctuations in the blood oxygenation level-dependent (BOLD) signal during rest reflect the neuronal baseline activity of the brain, representing the state of the human brain in the absence of ..
  4. pmc Resting-state functional connectivity in major depression: abnormally increased contributions from subgenual cingulate cortex and thalamus
    Michael D Greicius
    Department of Neurology and Neurological Sciences, Stanford University Medical Center, Stanford, California 94305 5235, USA
    Biol Psychiatry 62:429-37. 2007
    ..The goal of this study was to examine resting-state, default-mode network functional connectivity in subjects with major depression and in healthy controls...
  5. pmc The impact of global signal regression on resting state correlations: are anti-correlated networks introduced?
    Kevin Murphy
    Section on Functional Imaging Methods, National Institute of Mental Health, Bethesda, MD 20892 1148, USA
    Neuroimage 44:893-905. 2009
    ..These results call into question the interpretation of negatively correlated regions in the brain when using global signal regression as an initial processing step...
  6. ncbi Altered baseline brain activity in children with ADHD revealed by resting-state functional MRI
    Yu Feng Zang
    National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing, China
    Brain Dev 29:83-91. 2007
    ..This resting-state fMRI study suggests that the changed spontaneous neuronal activity of these regions may be implicated in the underlying pathophysiology in children with ADHD...
  7. pmc NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses
    Anita E Autry
    Department of Psychiatry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9111, USA
    Nature 475:91-5. 2011
    ..We find that the ketamine-mediated blockade of NMDAR at rest deactivates eukaryotic elongation factor 2 (eEF2) kinase (also called CaMKIII), resulting in reduced eEF2 ..
  8. ncbi Frequencies contributing to functional connectivity in the cerebral cortex in "resting-state" data
    D Cordes
    Department of Medical Physics, University of Wisconsin at Madison, 1300 University Ave, 1530 MSC, Madison, WI 53706, USA
    AJNR Am J Neuroradiol 22:1326-33. 2001
    ..In functionally connected regions, these low frequencies are characterized by a high degree of temporal coherence...
  9. ncbi Reduced resting-state brain activity in the "default network" in normal aging
    J S Damoiseaux
    Department of Neurology, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    Cereb Cortex 18:1856-64. 2008
    ..Ten younger and 22 older subjects were scanned at "rest," that is, lying awake with eyes closed...
  10. pmc The global signal and observed anticorrelated resting state brain networks
    Michael D Fox
    Departments of Radiology, Washington University in St Louis, St Louis, Missouri, USA
    J Neurophysiol 101:3270-83. 2009
    ....
  11. pmc The resting brain: unconstrained yet reliable
    Zarrar Shehzad
    Phyllis Green and Randolph Cowen Institute for Pediatric Neuroscience, NYU Child Study Center, New York, NY 10016, USA
    Cereb Cortex 19:2209-29. 2009
    ..Finally, hierarchical clustering solutions were highly reproducible, both across participants and sessions. Our findings provide a solid foundation for continued examination of resting state fcMRI in typical and atypical populations...
  12. ncbi fMRI resting state networks define distinct modes of long-distance interactions in the human brain
    M De Luca
    Oxford Centre for Functional Magnetic Resonance Imaging of the Brain, UK
    Neuroimage 29:1359-67. 2006
    ..Because RSNs reflect interactions in cognitively relevant functional networks, they offer a new approach to the characterization of state changes with pathology and the effects of drugs...
  13. pmc The oscillating brain: complex and reliable
    Xi Nian Zuo
    Phyllis Green and Randolph Cōwen Institute for Pediatric Neuroscience at the New York University Child Study Center, New York, NY, USA
    Neuroimage 49:1432-45. 2010
    ..These results suggest that amplitude measures of LFO can contribute to further between-group characterization of existing and future "resting-state" fMRI datasets...
  14. pmc Hyperactivity and hyperconnectivity of the default network in schizophrenia and in first-degree relatives of persons with schizophrenia
    Susan Whitfield-Gabrieli
    Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 106:1279-84. 2009
    ..the neural network mediating the default mode of brain function, which typically exhibits greater activation during rest than during task, in patients in the early phase of schizophrenia and in young first-degree relatives of persons ..
  15. pmc Trouble at rest: how correlation patterns and group differences become distorted after global signal regression
    Ziad S Saad
    Scientific and Statistical Computing Core, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    Brain Connect 2:25-32. 2012
    ..We touch on the need for careful accounting of nuisance parameters when making group comparisons of correlation maps...
  16. ncbi Spontaneous low-frequency BOLD signal fluctuations: an fMRI investigation of the resting-state default mode of brain function hypothesis
    Peter Fransson
    MR Research Center, Cognitive Neurophysiology, Department of Clinical Neuroscience, Karolinska Institute Karolinska University Hospital, Stockholm, Sweden
    Hum Brain Mapp 26:15-29. 2005
    Recent neuroimaging studies have lead to the proposal that rest is characterized by an organized, baseline level of activity, a default mode of brain function that is suspended during specific goal-oriented mental activity...
  17. ncbi Cortical networks for working memory and executive functions sustain the conscious resting state in man
    B Mazoyer
    Groupe d'Imagerie Neurofonctionnelle, UMR6095, CNRS, LEA, , , Paris, France
    Brain Res Bull 54:287-98. 2001
    The cortical anatomy of the conscious resting state (REST) was investigated using a meta-analysis of nine positron emission tomography (PET) activation protocols that dealt with different cognitive tasks but shared REST as a common ..
  18. doi Discriminative analysis of resting-state functional connectivity patterns of schizophrenia using low dimensional embedding of fMRI
    Hui Shen
    College of Mechatronics and Automation, National University of Defense Technology, Changsha, Hunan 410073, China
    Neuroimage 49:3110-21. 2010
    ....
  19. doi Parcellation-dependent small-world brain functional networks: a resting-state fMRI study
    Jinhui Wang
    State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China
    Hum Brain Mapp 30:1511-23. 2009
    ..This study provides quantitative evidence on how the topological organization of brain networks is affected by the different parcellation strategies applied...
  20. pmc Zebrafish behavioral profiling links drugs to biological targets and rest/wake regulation
    Jason Rihel
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Science 327:348-51. 2010
    ..new factors such as ether-a-go-go-related gene (ERG) potassium channels and immunomodulators in the control of rest and locomotor activity...
  21. doi Functional connectivity of human striatum: a resting state FMRI study
    A Di Martino
    Phyllis Green and Randolph Cowen Institute for Pediatric Neuroscience, NYU Child Study Center, New York, NY 10016, USA
    Cereb Cortex 18:2735-47. 2008
    ..analysis of basal ganglia circuitry in humans through a functional magnetic resonance imaging examination during rest. Voxelwise regression analyses substantiated the hypothesized motor, cognitive, and affective divisions among ..
  22. pmc Comparison of characteristics between region-and voxel-based network analyses in resting-state fMRI data
    Satoru Hayasaka
    Biostatistical Sciences, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Neuroimage 50:499-508. 2010
    ..Our results demonstrate benefits of constructing the brain network at the finest scale the experiment will permit...
  23. doi Functionally linked resting-state networks reflect the underlying structural connectivity architecture of the human brain
    Martijn P van den Heuvel
    Rudolf Magnus Institute of Neuroscience, University Medical Center, Utrecht, The Netherlands
    Hum Brain Mapp 30:3127-41. 2009
    During rest, multiple cortical brain regions are functionally linked forming resting-state networks...
  24. pmc Anticorrelations in resting state networks without global signal regression
    Xiaoqian J Chai
    Department of Brain and Cognitive Sciences, McGovern Institute for Brain Research and Poitras Center for Affective Disorders Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Neuroimage 59:1420-8. 2012
    ..anticorrelations observed in resting-state connectivity are not an artifact introduced by global signal regression and might have biological origins, and that the CompCor method can be used to examine valid anticorrelations during rest.
  25. pmc Ageing and the circadian and homeostatic regulation of human sleep during forced desynchrony of rest, melatonin and temperature rhythms
    D J Dijk
    Circadian, Neuroendocrine and Sleep Disorders Section, Division of Endocrinology, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Physiol 516:611-27. 1999
    ....
  26. pmc Learning sculpts the spontaneous activity of the resting human brain
    Christopher M Lewis
    Department of Clinical Sciences and Bioimaging, G D Annunzio University, Via dei Vestini 33, 66100, Chieti, Italy
    Proc Natl Acad Sci U S A 106:17558-63. 2009
    ..human brain is the interregional temporal correlation of the blood-oxygen level-dependent (BOLD) signal recorded at rest by functional MRI (functional connectivity-by-MRI, fcMRI, or BOLD connectivity)...
  27. ncbi Rest in Drosophila is a sleep-like state
    J C Hendricks
    Center for Sleep and Respiratory Neurobiology, School of Medicine, University of Pennsylvania, Philadelphia 19104, USA
    Neuron 25:129-38. 2000
    To facilitate the genetic study of sleep, we documented that rest behavior in Drosophila melanogaster is a sleep-like state...
  28. pmc Neural basis of global resting-state fMRI activity
    Marieke L Schölvinck
    Unit on Cognitive Neurophysiology and Imaging, Laboratory of Neuropsychology, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 107:10238-43. 2010
    Functional MRI (fMRI) has uncovered widespread hemodynamic fluctuations in the brain during rest. Recent electroencephalographic work in humans and microelectrode recordings in anesthetized monkeys have shown this activity to be ..
  29. pmc Consistency and functional specialization in the default mode brain network
    Ben J Harrison
    Institut d Alta Tecnologia Parc de Recerca Biomèdica de Barcelona, CRC Corporació Sanitària, 08003 Barcelona, Spain
    Proc Natl Acad Sci U S A 105:9781-6. 2008
    ..and midline cortical regions that show prominent activity fluctuations during passive imaging states, such as rest. In this study, we perform three fMRI experiments that demonstrate consistency and specialization in the default ..
  30. ncbi Amplitude of low frequency fluctuation within visual areas revealed by resting-state functional MRI
    Hong Yang
    Huaxi MR Research Center HMRRC, Department of Radiology, West China Hospital of Sichuan University, Chengdu, China
    Neuroimage 36:144-52. 2007
    ..Our finding of the distinct ALFF difference between EO and EC in the visual cortex implies that the ALFF may be a novel biomarker for physiological states of the brain...
  31. doi Impairment and compensation coexist in amnestic MCI default mode network
    Zhigang Qi
    Department of Radiology, Xuanwu Hospital of Capital University of Medical Sciences, Beijing 100053, PR China
    Neuroimage 50:48-55. 2010
    ..These findings suggest that abnormal DMN activity could be useful as an imaging-based biomarker for the diagnosis and monitoring of aMCI patients...
  32. pmc Reorganizing the intrinsic functional architecture of the human primary motor cortex during rest with non-invasive cortical stimulation
    Rafael Polania
    Department of Clinical Neurophysiology, Georg August University of Gottingen, Gottingen, Germany
    PLoS ONE 7:e30971. 2012
    ..fMRI resting-state datasets were acquired immediately before and after 10 minutes of tDCS during rest, with the anode/cathode placed over the left M1...
  33. pmc Resting-state functional connectivity reflects structural connectivity in the default mode network
    Michael D Greicius
    Department of Neurology, Stanford University School of Medicine, Stanford, CA 94304, USA
    Cereb Cortex 19:72-8. 2009
    ..detects temporal correlations in spontaneous blood oxygen level-dependent (BOLD) signal oscillations while subjects rest quietly in the scanner...
  34. pmc Scale-free properties of the functional magnetic resonance imaging signal during rest and task
    Biyu J He
    National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 31:13786-95. 2011
    ..the fMRI signal decrease during task activation, suggesting that the signal contains more long-range memory during rest and conversely is more efficient at online information processing during task...
  35. doi Neuronal correlates of spontaneous fluctuations in fMRI signals in monkey visual cortex: Implications for functional connectivity at rest
    Amir Shmuel
    Montreal Neurological Institute, Departments of Neurology and Neurosurgery and Biomedical Engineering, McGill University, Montreal, QC, Canada
    Hum Brain Mapp 29:751-61. 2008
    ....
  36. pmc Decoupling of the brain's default mode network during deep sleep
    Silvina G Horovitz
    Human Motor Control Section, Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 106:11376-81. 2009
    ..This suggests that DMN may play an important role in the sustenance of conscious awareness...
  37. ncbi Default-mode activity during a passive sensory task: uncoupled from deactivation but impacting activation
    Michael D Greicius
    Department of Neurology, Stanford University School of Medicine, CA 94301 5719, USA
    J Cogn Neurosci 16:1484-92. 2004
    Deactivation refers to increased neural activity during low-demand tasks or rest compared with high-demand tasks...
  38. pmc Modulation of temporally coherent brain networks estimated using ICA at rest and during cognitive tasks
    Vince D Calhoun
    Olin Neuropsychiatry Research Center, Institute of Living, Hartford, Connecticut 06106, USA
    Hum Brain Mapp 29:828-38. 2008
    ..Such networks are often identified in the context of an fMRI scan collected during rest (and thus are called "resting state networks"); however, they are also present during (and modulated by) the ..
  39. doi Selective aberrant functional connectivity of resting state networks in social anxiety disorder
    Wei Liao
    Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, PR China
    Neuroimage 52:1549-58. 2010
    ..Our results might supply a novel way to look into neuro-pathophysiological mechanisms in SAD patients...
  40. ncbi Functional connectivity in a baseline resting-state network in autism
    Vladimir L Cherkassky
    Center for Cognitive Brain Imaging, Department of Psychology, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, USA
    Neuroreport 17:1687-90. 2006
    ..This functional underconnectivity was observed in the anterior-posterior connections. The results expand the theory of cortical underconnectivity in autism to the resting state of the brain...
  41. doi Changes of functional connectivity of the motor network in the resting state in Parkinson's disease
    Tao Wu
    Department of Neurobiology, Key Laboratory on Neurodegenerative Disorders of Ministry of Education, Beijing Institute of Geriatrics, Xuanwu Hospital, Capital Medical University, Beijing, China
    Neurosci Lett 460:6-10. 2009
    ..We postulate that this abnormal functional connectivity of motor network in the baseline state is possibly an important factor contributing to some motor deficits in PD, e.g. akinesia...
  42. pmc Functional resting-state networks are differentially affected in schizophrenia
    Neil D Woodward
    Psychotic Disorders Program, Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, TN, United States
    Schizophr Res 130:86-93. 2011
    ..Further work is needed to determine if the alterations are related to disturbances in white matter connectivity, neurodevelopmental abnormalities, and genetic risk for schizophrenia...
  43. doi Sleep deprivation reduces default mode network connectivity and anti-correlation during rest and task performance
    Jack A De Havas
    Cognitive Neuroscience Laboratory, Duke NUS Graduate Medical School, Singapore
    Neuroimage 59:1745-51. 2012
    ..This was congruent across resting state and VAT analyses, suggesting that SD induces a robust alteration in the intrinsic connectivity within and between these networks...
  44. doi Test-retest reliability of resting-state connectivity network characteristics using fMRI and graph theoretical measures
    Urs Braun
    Central Institute of Mental Health, University of Heidelberg, J5, 68159 Mannheim, Germany
    Neuroimage 59:1404-12. 2012
    ..networks derived from functional magnetic resonance imaging (fMRI) recorded in 33 healthy subjects during rest. We constructed undirected networks based on the Anatomic-Automatic-Labeling (AAL) atlas template and calculated ..
  45. pmc Inter-individual differences in resting-state functional connectivity predict task-induced BOLD activity
    Maarten Mennes
    Phyllis Green and Randolph Cōwen Institute for Pediatric Neuroscience at the NYU Child Study Center, 215 Lexington Avenue 14th Floor, New York, NY 10016, USA
    Neuroimage 50:1690-701. 2010
    ..These results suggest that a common mechanism governs many brain regions' neural activity during rest and its neural activity during task performance.
  46. pmc Task-induced deactivation from rest extends beyond the default mode brain network
    Ben J Harrison
    Institut d Alta Tecnologia PRBB, CRC MAR, Hospital del Mar, Barcelona, Spain
    PLoS ONE 6:e22964. 2011
    ..neuroimaging studies that compare periods of task-based cognitive performance with passive states, such as rest. It is now widely held that such task-induced deactivations index a highly organized 'default-mode network' (DMN): ..
  47. pmc Frequency-dependent functional connectivity within resting-state networks: an atlas-based MEG beamformer solution
    Arjan Hillebrand
    Department of Clinical Neurophysiology and Magnetoencephalography Center, VU University Medical Center, Amsterdam, The Netherlands
    Neuroimage 59:3909-21. 2012
    ....
  48. doi Default mode network as revealed with multiple methods for resting-state functional MRI analysis
    Xiang Yu Long
    State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing 100875, China
    J Neurosci Methods 171:349-55. 2008
    ..Moreover, the current results provided evidences that the brain areas within the two anti-correlated networks are highly integrated at both the intra- and inter-regional level...
  49. pmc Enhanced brain correlations during rest are related to memory for recent experiences
    Arielle Tambini
    Center for Neural Science, New York University, 4 Washington Place, New York, NY 10003, USA
    Neuron 65:280-90. 2010
    ..Here, using functional magnetic resonance imaging, we examined if hippocampal-cortical BOLD correlations during rest following an associative encoding task are related to later associative memory performance...
  50. doi BOLD correlates of EEG topography reveal rapid resting-state network dynamics
    Juliane Britz
    Department of Fundamental Neuroscience, University of Geneva, Geneva, Switzerland
    Neuroimage 52:1162-70. 2010
    ..slowly oscillating fMRI-defined resting states, we recorded 64-channel EEG in the scanner while subjects were at rest with their eyes closed...
  51. ncbi Transcriptional regulation of gene expression in human skeletal muscle during recovery from exercise
    H Pilegaard
    Copenhagen Muscle Research Centre, The August Krogh Institute, University of Copenhagen, DK 2100 Copenhagen, Denmark
    Am J Physiol Endocrinol Metab 279:E806-14. 2000
    ....
  52. pmc Addiction related alteration in resting-state brain connectivity
    Ning Ma
    Division of Bio X Interdisciplinary Sciences at the Hefei National Laboratory for Physical Sciences at Microscale, Department of Neurobiology and Biophysics, School of Life Sciences, University of Science and Technology of China, Hefei, Anhui, China
    Neuroimage 49:738-44. 2010
    ....
  53. doi Resting-state functional network correlates of psychotic symptoms in schizophrenia
    Anna Rotarska-Jagiela
    Max Planck Institute for Brain Research, Department of Neurophysiology, Deutschordenstr 46, 60528 Frankfurt a M, Germany
    Schizophr Res 117:21-30. 2010
    ....
  54. doi Rest-stimulus interaction in the brain: a review
    Georg Northoff
    Institute of Mental Health Research, University of Ottawa, Ottawa, ON K1Z 7K4, Canada
    Trends Neurosci 33:277-84. 2010
    ..Psychologically, the rest-stimulus interaction is relevant to predicting subsequent behavioral and mental states...
  55. doi Decreased basal fMRI functional connectivity in epileptogenic networks and contralateral compensatory mechanisms
    Gaelle Bettus
    Centre de Resonance Magnetique Biologique et Medicale, UMR CNRS 6612, Faculte de Medecine, 27 Boulevard Jean Moulin, Marseille, France
    Hum Brain Mapp 30:1580-91. 2009
    ..This is the first demonstration of decreased basal functional connectivity within epileptogenic networks with concomitant contralateral increased connectivity possibly reflecting compensatory mechanisms...
  56. pmc Noise during rest enables the exploration of the brain's dynamic repertoire
    Anandamohan Ghosh
    Theoretical Neuroscience Group, Institut des Sciences du Mouvement, Marseille, France
    PLoS Comput Biol 4:e1000196. 2008
    ..However, even at rest, in the absence of overt goal-directed behavior, collections of cortical regions consistently show temporally ..
  57. pmc Functional connectivity of the human amygdala using resting state fMRI
    Amy Krain Roy
    Phyllis Green and Randolph Cowen Institute for Pediatric Neuroscience, NYU Child Study Center, New York, NY 10016, USA
    Neuroimage 45:614-26. 2009
    ..These findings suggest that resting state fMRI can be used to investigate human amygdala networks at a greater level of detail than previously appreciated, allowing for the further advancement of translational models...
  58. pmc The resting human brain and motor learning
    Neil B Albert
    Behavioural and Brain Sciences Centre, School of Psychology, University of Birmingham, Birmingham B155 2TT, UK
    Curr Biol 19:1023-7. 2009
    ..BOLD signal was recorded during rest periods before and after an 11 min visuomotor training session...
  59. doi Resting oscillatory cortico-subthalamic connectivity in patients with Parkinson's disease
    Vladimir Litvak
    Sobell Department of Motor Neuroscience, UCL Institute of Neurology, London, UK
    Brain 134:359-74. 2011
    ..and subthalamic local field potential recordings in thirteen patients with Parkinson's disease at rest. Two spatially and spectrally separated networks were identified...
  60. ncbi Functional connectivity as revealed by spatial independent component analysis of fMRI measurements during rest
    Vincent G van de Ven
    Laboratory for Neurophysiology and Neuroimaging, Department of Psychiatry, Johann Wolfgang Goethe University, Frankfurt, Germany
    Hum Brain Mapp 22:165-78. 2004
    ..These results are discussed in the context of the recent debate on the functional relevance of fluctuations of neural activity in the resting state...
  61. pmc Resting-state networks in the infant brain
    Peter Fransson
    Magnetic Resonance Research Center, Department of Clinical Neuroscience, Stockholm Brain Institute, Karolinska Institute, SE 171 77 Stockholm, Sweden
    Proc Natl Acad Sci U S A 104:15531-6. 2007
    ..The potential link between the emergence of behavior and patterns of resting-state activity in the infant brain is discussed...
  62. doi Abnormal regional brain activity during rest and (anticipated) gastric distension in functional dyspepsia and the role of anxiety: a H(2)(15)O-PET study
    Lukas Van Oudenhove
    Department of Neurosciences, Psychiatry Division, University Hospital Gasthuisberg, University of Leuven, Leuven, Belgium
    Am J Gastroenterol 105:913-24. 2010
    ....
  63. ncbi Frontal theta EEG activity correlates negatively with the default mode network in resting state
    Rene Scheeringa
    F C Donders Centre for Cognitive Neuroimaging, Radboud University Nijmegen, The Netherlands
    Int J Psychophysiol 67:242-51. 2008
    ..Extensive negative correlations were observed in the areas that together form the default mode network. We conclude that frontal theta activity can be seen as an EEG index of default mode network activity...
  64. pmc Interaction between dysfunctional connectivity at rest and heroin cues-induced brain responses in male abstinent heroin-dependent individuals
    Jixin Liu
    Life Sciences Research Center, School of Life Sciences and Technology, Xidian University, Xi an, Shaanxi, China
    PLoS ONE 6:e23098. 2011
    ..Yet few studies considered the relevance of resting state dysfunctional connectivity to task-related neural activity in the same chronic heroin user (CHU)...
  65. ncbi The relationship within and between the extrinsic and intrinsic systems indicated by resting state correlational patterns of sensory cortices
    Lixia Tian
    Department of Biomedical Engineering, School of Computer and Information Technology, Beijing Jiaotong University, Beijing 100044, PR China
    Neuroimage 36:684-90. 2007
    ..We suggest that these negative correlations between the extrinsic and intrinsic systems may explain the phenomenon that externally and internally oriented processes can always disturb or even interrupt each other...
  66. doi Efficacy of the novel antidepressant agomelatine on the circadian rest-activity cycle and depressive and anxiety symptoms in patients with major depressive disorder: a randomized, double-blind comparison with sertraline
    Siegfried Kasper
    Department of Psychiatry and Psychotherapy, Medical University Vienna, MUV, AKH, Wahringer Gurtel 18 20, A 1090 Wien, Austria
    J Clin Psychiatry 71:109-20. 2010
    ..at MT(1)/MT(2) receptors and an antagonist at 5-HT(2C) receptors, versus sertraline with regard to the amplitude of the circadian rest-activity cycle and depressive and anxiety symptoms in patients with major depressive disorder (MDD).
  67. ncbi Resting fluctuations in arterial carbon dioxide induce significant low frequency variations in BOLD signal
    Richard G Wise
    Centre for Functional Magnetic Resonance Imaging of the Brain, Department of Clinical Neurology, John Radcliffe Hospital, University of Oxford, Oxford, UK
    Neuroimage 21:1652-64. 2004
    ..imaging (MRI) signal at 3 T arising from spontaneous fluctuations in arterial carbon dioxide level in volunteers at rest. Fluctuations in the partial pressure of end-tidal carbon dioxide (Pet(CO(2))) of +/-1...
  68. ncbi Unrest at rest: default activity and spontaneous network correlations
    Randy L Buckner
    Department of Psychology, Center for Brain Science, Harvard University, and Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Cambridge 02138, USA
    Neuroimage 37:1091-6; discussion 1097-9. 2007
    ..We believe these rest activity patterns may reflect neural functions that consolidate the past, stabilize brain ensembles, and prepare us ..
  69. doi Decreased regional homogeneity in insula and cerebellum: a resting-state fMRI study in patients with major depression and subjects at high risk for major depression
    Zhifen Liu
    Department of Psychiatry, First Hospital of Shanxi Medical University, Taiyuan, PR China
    Psychiatry Res 182:211-5. 2010
    ..These abnormalities may play an important role in the pathophysiology of depression...
  70. ncbi Increase in muscle nociceptive substances and anaerobic metabolism in patients with trapezius myalgia: microdialysis in rest and during exercise
    Lars Rosendal
    National Institute of Occupational Health, Lersø Parkallé 105, DK 2100 Copenhagen, Denmark
    Pain 112:324-34. 2004
    ..with chronic work-related trapezius myalgia (TM) and 20 healthy female controls (CON) were studied during baseline rest, 20 min repetitive low-force exercise, and 120 min recovery...
  71. pmc Amplitude of low-frequency oscillations in schizophrenia: a resting state fMRI study
    Matthew J Hoptman
    Division of Clinical Research, Nathan Kline Institute, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
    Schizophr Res 117:13-20. 2010
    ..These results suggest LFO abnormalities in schizophrenia. The implication of these abnormalities for schizophrenic symptomatology is further discussed...
  72. doi Altered functional connectivity in default mode network in absence epilepsy: a resting-state fMRI study
    Cheng Luo
    Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China
    Hum Brain Mapp 32:438-49. 2011
    ..Abnormal functional connectivity in absence epilepsy may reflect abnormal anatomo-functional architectural integration in DMN, as a result of cognitive mental impairment and unconsciousness during absence seizure...
  73. ncbi Functional disintegration in paranoid schizophrenia using resting-state fMRI
    Yuan Zhou
    National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing 100080, PR China
    Schizophr Res 97:194-205. 2007
    ..We sought to investigate functional disintegration during rest because an intrinsic functional brain organization, including both "task-negative" (i.e...
  74. pmc Dissociable effects of methylphenidate, atomoxetine and placebo on regional cerebral blood flow in healthy volunteers at rest: a multi-class pattern recognition approach
    Andre F Marquand
    Department of Neuroimaging, Centre for Neuroimaging Sciences, Institute of Psychiatry, King s College London, UK
    Neuroimage 60:1015-24. 2012
    ..Our results demonstrate that combining ASL and PR yields a sensitive method for detecting the effects of these drugs and provides insights into the regional distribution of brain networks potentially modulated by these compounds...
  75. ncbi Organization of ipsilateral excitatory and inhibitory pathways in the human motor cortex
    Robert Chen
    Division of Neurology, Krembil Neuroscience Center and Toronto Western Research Institute, University Health Network, University of Toronto, Toronto, Ontario M5T 2S8, Canada
    J Neurophysiol 89:1256-64. 2003
    ..iSP and IHI do not represent the same phenomenon and should be considered complementary measures of ipsilateral inhibition...
  76. pmc Reading networks at rest
    Maki S Koyama
    Phyllis Green and Randolph Cowen Institute for Pediatric Neuroscience, New York University Child Study Center, New York, NY 10016, USA
    Cereb Cortex 20:2549-59. 2010
    ..In conclusion, the current study supports the utility of resting-state fMRI for investigating reading networks and has direct relevance for the understanding of reading disorders such as dyslexia...
  77. doi Resting state networks change in clinically isolated syndrome
    Stefan D Roosendaal
    VU University Medical Centre, Department of Radiology, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Brain 133:1612-21. 2010
    ..The study of the brain 'at rest' may provide additional information, because task-induced metabolic changes are relatively small compared to the ..
  78. pmc Blood pressure variability and closed-loop baroreflex assessment in adolescent chronic fatigue syndrome during supine rest and orthostatic stress
    Vegard Bruun Wyller
    Department of Pediatrics, Rikshospitalet University Hospital, 0027, Oslo, Norway
    Eur J Appl Physiol 111:497-507. 2011
    ..The aim of this study was to explore blood pressure variability and closed-loop baroreflex function at rest and during mild orthostatic stress in adolescents with CFS...
  79. pmc The dynamical balance of the brain at rest
    Gustavo Deco
    Institucio Catalana de Recerca i Estudis Avancats, Universitat Pompeu Fabra, Departmet of Technology, Computational Neuroscience, Barcelona, Spain
    Neuroscientist 17:107-23. 2011
    ..Some RSN are functionally organized as dynamically competing systems both at rest and during tasks...
  80. doi Are emotions associated with activity during rest or interoception? An exploratory fMRI study in healthy subjects
    Christine Wiebking
    Clinic of Psychiatry, Otto von Guericke University, Magdeburg, Germany
    Neurosci Lett 491:87-92. 2011
    ..the default-mode network (DMN) of the brain revealed the phenomenon of elevated neural responses during periods of rest. This effect has been shown to be abnormally elevated in regions of the DMN concerning mood disorders like major ..
  81. ncbi Daily physical-rest activities in relation to nutritional state, metabolism, and quality of life in cancer patients with progressive cachexia
    Marita Fouladiun
    Surgical Metabolic Research Laboratory at Lundberg Laboratory for Cancer Research, Sahlgrenska University Hospital, Goteborg, Sweden
    Clin Cancer Res 13:6379-85. 2007
    To evaluate daily physical-rest activities in cancer patients losing weight in relation to disease progression.
  82. pmc Disruption of ripple-associated hippocampal activity during rest impairs spatial learning in the rat
    Valérie Ego-Stengel
    Department of Brain and Cognitive Sciences, The Picower Institute for Learning and Memory, RIKEN MIT Neuroscience Research Center, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    Hippocampus 20:1-10. 2010
    ..We trained rats daily in two identical spatial navigation tasks followed each by a 1-hour rest period...
  83. doi Spontaneous low-frequency blood oxygenation level-dependent fluctuations and functional connectivity analysis of the 'resting' brain
    Dorothee P Auer
    Academic Radiology, Queen s Medical Centre, University of Nottingham, Nottingham, UK
    Magn Reson Imaging 26:1055-64. 2008
    ..evidence for a neural basis opening exciting new avenues to study human brain function and its connectivity at rest. Moreover, an increasing number of patient studies report disease-dependent variation in the amplitude and spatial ..
  84. pmc Task-dependent organization of brain regions active during rest
    Uri Hasson
    Center for Mind Brain Sciences and Faculty of Cognitive Sciences, University of Trento, 38060 Mattarello, TN, Italy
    Proc Natl Acad Sci U S A 106:10841-6. 2009
    The human brain demonstrates complex yet systematic patterns of neural activity at rest. We examined whether functional connectivity among those brain regions typically active during rest depends on ongoing and recent task demands and ..
  85. ncbi Abnormal functional connectivity in Alzheimer's disease: intrahemispheric EEG coherence during rest and photic stimulation
    Y Wada
    Department of Neuropsychiatry, Kanazawa University School of Medicine, Japan
    Eur Arch Psychiatry Clin Neurosci 248:203-8. 1998
    ..The present study was conducted to examine intrahemispheric EEG coherence at rest and during photic stimulation (PS; 5, 10 and 15 Hz) in ten unmedicated patients with presenile dementia of the ..
  86. ncbi Watching social interactions produces dorsomedial prefrontal and medial parietal BOLD fMRI signal increases compared to a resting baseline
    Marco Iacoboni
    UCLA Brain Mapping Center, University of California, Los Angeles, CA 90095, USA
    Neuroimage 21:1167-73. 2004
    ..visual observation of laboratory stimuli typically yields no change in activity in these default areas compared to rest. Here we report functional magnetic resonance imaging (fMRI) data on normal subjects watching realistic movie clips ..
  87. doi Individualization of transfer function in estimation of central aortic pressure from the peripheral pulse is not required in patients at rest
    Berend E Westerhof
    BMEYE B V, Academic Medical Center, Suite K2 245, Univ of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    J Appl Physiol (1985) 105:1858-63. 2008
    ..In a group of 50 patients at rest, aged 28-66 yr (43 men), undergoing diagnostic angiography, ascending aortic pressure was 119 +/- 20/70 +/- 9 mmHg (..
  88. pmc Association between functional connectivity hubs and brain networks
    Dardo Tomasi
    National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892, USA
    Cereb Cortex 21:2003-13. 2011
    ..The significant variability among functional networks may underlie their sensitivity/resilience to neuropathology...
  89. doi Brain activity at rest: a multiscale hierarchical functional organization
    Gaëlle Doucet
    Univ de Bordeaux, Bordeaux, France
    J Neurophysiol 105:2753-63. 2011
    ..Functional connectivity analyses revealed that M1b played a central role in the functioning of the intrinsic system, whereas M1c seems to mediate exchange of information between the intrinsic and extrinsic systems...
  90. doi Circadian rest-activity rhythm is altered in Parkinson's disease patients with hallucinations
    Daisy L Whitehead
    King s College London, Institute of Psychiatry, MRC Centre for Neurodegeneration, London, United Kingdom
    Mov Disord 23:1137-45. 2008
    ..This study compared rest-activity rhythms in healthy older adults and PD patients with and without hallucinations...
  91. ncbi Ultrasonographic evaluation of reticular motility during rest, eating, rumination and stress in 30 healthy cows
    U Braun
    Department of Farm Animals, University of Zurich, Winterthurerstrasse 260, CH 8057 Zurich, Switzerland
    Vet Rec 163:571-4. 2008
    ..was used to assess the motility of the reticulum in 30 healthy, standing, non-sedated cows while they were at rest, eating, ruminating and under stress...
  92. doi Functional connectivity of the insula in the resting brain
    Franco Cauda
    CCS fMRI, Koelliker Hospital, Turin, Italy
    Neuroimage 55:8-23. 2011
    ..These results are in agreement with connectivity studies in primates, and support the use of resting state functional analysis to investigate connectivity in the living human brain...
  93. pmc Differential stimulation of myofibrillar and sarcoplasmic protein synthesis with protein ingestion at rest and after resistance exercise
    Daniel R Moore
    Exercise Metabolism Research Group, Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada
    J Physiol 587:897-904. 2009
    ..These data highlight the importance of measuring the synthetic response of specific muscle protein fractions when examining the effects of exercise and nutrition...
  94. ncbi GABA concentrations in the human anterior cingulate cortex predict negative BOLD responses in fMRI
    Georg Northoff
    Department of Psychiatry, Otto von Guericke University Magdeburg, Leipziger Strasse 44, 39120 Magdeburg, Germany
    Nat Neurosci 10:1515-7. 2007
    ..Our findings show that default-mode network negative BOLD responses during emotions are mediated by GABA...
  95. pmc A critical role for the right fronto-insular cortex in switching between central-executive and default-mode networks
    Devarajan Sridharan
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 105:12569-74. 2008
    ..Our findings have important implications for a unified view of network mechanisms underlying both exogenous and endogenous cognitive control...
  96. ncbi Impact of resistance exercise during bed rest on skeletal muscle sarcopenia and myosin isoform distribution
    M M Bamman
    Department of Human Studies, University of Alabama at Birmingham 35294, USA
    J Appl Physiol (1985) 84:157-63. 1998
    Because resistance exercise (REx) and bed-rest unloading (BRU) are associated with opposing adaptations, our purpose was to test the efficacy of REx against the effects of 14 days of BRU on the knee-extensor muscle group...
  97. doi Abnormal neural activity in the patients with remitted geriatric depression: a resting-state functional magnetic resonance imaging study
    Yonggui Yuan
    School of Clinical Medicine, Southeast University, Nanjing, 210009, China
    J Affect Disord 111:145-52. 2008
    ....
  98. pmc Impact of working memory load on FMRI resting state pattern in subsequent resting phases
    Martin Pyka
    Department of Psychiatry, University of Munster, Munster, Germany
    PLoS ONE 4:e7198. 2009
    ..a functional network with increasing relevance for psychiatric research, characterized by increased activation at rest and decreased activation during task performance...
  99. ncbi Randomized, dim light controlled, crossover test of morning bright light therapy for rest-activity rhythm disorders in patients with vascular dementia and dementia of Alzheimer's type
    K Mishima
    Department of Neuropsychiatry, Akita University School of Medicine, Japan
    Chronobiol Int 15:647-54. 1998
    The authors compared the therapeutic effect of morning bright and dim light exposure on rest-activity (R-A) rhythm disorders in patients with vascular dementia (VD) and patients with dementia of Alzheimer's type (DAT)...
  100. ncbi Resting energy expenditure-fat-free mass relationship: new insights provided by body composition modeling
    Z Wang
    Obesity Research Center, St Luke s Roosevelt Hospital, College of Physicians and Surgeons, Columbia University, New York, New York 10025, USA
    Am J Physiol Endocrinol Metab 279:E539-45. 2000
    ....
  101. pmc Myocardial and skeletal muscle glucose uptake during exercise in humans
    Jukka Kemppainen
    Turku PET Centre, University of Turku, PO Box 52, 20521 Turku, Finland
    J Physiol 542:403-12. 2002
    ..Twelve healthy men were studied during rest, while 14 subjects were studied after 35 min of bicycle exercise corresponding to 30, 55 and 75 % of maximal oxygen ..

Research Grants86

  1. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2013
    ..Participants will have study visits once a month for the first 2 months and then every other month for the rest of the study. Each study visit will involve eye exams and blood and urine tests...
  2. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2012
    ..Participants will have study visits once a month for the first 2 months and then every other month for the rest of the study. Each study visit will involve eye exams and blood and urine tests...
  3. Understanding/ Treating Neuropsychiatric Symptoms of Pediatric Physical Illness
    Eva Szigethy; Fiscal Year: 2009
    ..abstract_text> ..
  4. NIH Director's Pioneer Award
    Junying Yuan; Fiscal Year: 2009
    ..No Abstract provided ..
  5. Genome-wide recombination as a risk factor for nondisjunction
    NATASHA D HOLLIS; Fiscal Year: 2010
    ..The goal of the work presented in this proposal is to look at recombination patterns in the rest of the genome to determine if the altered patterns observed on chromosome 21 are due to cis-acting or trans-acting ..
  6. Enhanced iron removal with peptide linked chelators targeted to ferritin
    Elizabeth C Theil; Fiscal Year: 2010
    ..The experiments rest on research supported by the NIH through the RO1 mechanism, the derived invention patented in 2007, and a contract ..
  7. Skeletal Muscle. Ca Release Control Inside the Sarcoplasmic Reticulum.
    Eduardo Rios; Fiscal Year: 2013
    ..In skeletal muscle these signals make the difference between rest and motion, thus influencing multiple aspects of our life, including physical conditioning, metabolism, and even ..
  8. Role of the Mammalian Siderophore in Cellular Iron Metabolism and Erythropoiesis
    Laxminarayana R Devireddy; Fiscal Year: 2012
    ..Hemoglobin is an iron rich protein that gives red color to the blood and it also carries oxygen to the rest of the body. This grant aims to study the molecular mechanisms underlying hemoglobin formation in the bone marrow...
  9. BONE MATRIX AND BONE RESORPTION
    Paul R Odgren; Fiscal Year: 2012
    ..The ia rat protein has an intact RUN domain, lacks the rest of the protein, and fails to localize with Rab7 vesicles...
  10. BRIAN JAMES MICKEY; Fiscal Year: 2015
    ..differentially during processing of monetary loss versus gain and (ii) patterns of functional connectivity at rest. (Aligns with Training Objective 2.) Summary...
  11. Intrathoracic Pressure Regulator for Resuscitation
    Keith G Lurie; Fiscal Year: 2011
    ..decrease in intrathoracic pressure, typically to -7 to -9 mmHg, creates a vacuum within the thorax relative to the rest of the body thereby a) significantly enhancing blood return to the heart and consequently increasing cardiac output ..
  12. Needle-Implantable, Wireless Multi-Sensor for Continuous Glucose Monitoring
    Santhisagar Vaddiraju; Fiscal Year: 2010
    ..23.6 and 189 million diabetic patients in US and rest of the world, respectively) poses a serious health problem, especially when associated with obesity, renal failure ..
  13. Vijay Sharma; Fiscal Year: 2015
    ..agent by assessment of myocardial infarct size, first pass extraction, and flow-extraction correlation under stress/rest conditions in rats, followed by assessment of leads in rabbits, using microPET imaging...
  14. Severe H1N1 Influenza Infection During Pregnancy: Pathophysiologic Mechanisms
    Mark Phillippe; Fiscal Year: 2010
    ..caused by a novel strain of H1N1 influenza began in Mexico, and then rapidly spread to the United States and the rest of the world leading the World Health Organization (WHO) to declare a global influenza pandemic on June 11th...
  15. Mechanisms of Astrocyte Development
    Teri L Belecky Adams; Fiscal Year: 2010
    ..act as an attractant for ganglion cell axons as they leave the eye to grow towards other target cells in the rest of the central nervous system...
  16. Activity Dependent Signaling in Adult Skeletal Muscle Fiber Plasticity
    Martin F Schneider; Fiscal Year: 2012
    ..Lack of muscle activity in bed rest, various disease states and aging contributes to the general decline in health under these conditions...
  17. Edward O McFalls; Fiscal Year: 2016
    ..In this model we will evaluate whether surgical revascularization normalizes regional blood flow at rest and with increased work load (dobutamine stress) by measuring blood flow (microsphere analysis) and cardiac ..
  18. Lucio G Costa; Fiscal Year: 2014
    ..Body burden of PBDEs in humans in North America is much higher than in the rest of the world, and it is highest in infants (because of exposure through breast milk) and in toddlers (because of ..
  19. COREY B SMITH; Fiscal Year: 2015
    ..Under sympathetic tone, selective and modest catecholamine release plays an important role in the "rest and digest" metabolic status of energy storage, regulating homeostatic physiological functions including pancreatic ..
  20. TNF-alpha Signaling in Silica-Induced Lung Fibrosis
    Luis A Ortiz; Fiscal Year: 2012
    ..also point out that Western Pennsylvania exhibits a much higher mortality due to silicosis when compared to the rest of the country and clusters of counties (where mining is an important activity) around the city of Pittsburgh are ..
  21. Maria Almira Correia; Fiscal Year: 2016
    ..The liver is a major supplier of proteins, lipids and nutrients to the rest of the body, and thus translational arrest of de novo synthesis coupled with enhanced ALD of hepatic proteins is ..
  22. Jeffrey A Simon; Fiscal Year: 2016
    ..The Polycomb group proteins then assume control to maintain Hox gene silencing during the rest of development. Thus, PcG proteins provide molecular memory of spatial cues present in early embryos...
  23. Muscle Wasting in Uremia
    Ralph Rabkin; Fiscal Year: 2012
    ..Since these illnesses often require bed-rest or limited mobilization, disuse atrophy of muscle sets in and worsens their condition and slows recovery...
  24. Development of a Wearable Passive Vibration Therapy System for the Lower Extremit
    JEFFREY MICHAEL LEISMER; Fiscal Year: 2010
    ..g., those in a bed rest or other reduced activity environments)...
  25. Drug Transport at the Blood-Testis Barrier
    Nathan J Cherrington; Fiscal Year: 2013
    ..blood-testis barrier, Sertoli cells separate the adluminal compartment of the seminiferous tubules (STs) from the rest of the body by the formation of tight junctions below developing germ cells...
  26. Francesca Tentori; Fiscal Year: 2015
    ..I will spend one week per month in Ann Arbor and the rest of the time in Nashville, where I live for family reasons...
  27. Improving pain and function in hip fracture
    R Sean Morrison; Fiscal Year: 2013
    ..with an increased risk of post-operative complications and delirium and has been shown to lead to prolonged bed rest, delayed ambulation, missed or shortened physical therapy sessions, impaired function six months following surgery, ..
  28. Novel non-invasive device for treatment of elevated intracranial pressures
    Keith G Lurie; Fiscal Year: 2011
    ..decrease in intrathoracic pressure, typically to -7 to -9 mmHg, creates a vacuum within the thorax relative to the rest of the body thereby a) enhancing blood return to the heart and consequently increasing cardiac output and blood ..
  29. Sleep in Rats: From Conceptualization to Measurement, Analysis and Interpretation
    Gayle Giboney Page; Fiscal Year: 2010
    ..before social defeat is initiated, before and after each social defeat / novel cage exposure, and during the 2-week rest period. Sleep outcomes include arousal state, latencies to state and sleep-state specific EEG spectral profiles...
  30. Novel bundled mechanical and pharmacological CPR platform
    Anja Metzger; Fiscal Year: 2012
    ..pressure between positive pressure ventilations which creates a vacuum within the thorax relative to the rest of the body that enhances venous blood return to the heart, increases cardiac output and systemic arterial blood ..
  31. Visualization of Pelvic Floor Reflexes
    CHRISTOS EURIPIDES CONSTANTINOU; Fiscal Year: 2010
    ..Bladder neck approximation will be lower at rest, during PFM contraction and Valsalva maneuvers in continent women...
  32. CHARLES ROBERT EVANS; Fiscal Year: 2015
    ..targeted metabolomic assays will be performed in skeletal muscle and plasma of LCR and HCR running rats at rest and during exercise...
  33. Jason David Allen; Fiscal Year: 2014
    ..nitrosothiols, plasma nitrotyrosine), cGMP during a maximal graded exercise test, and (c) vascular function at rest (endothelial function), calf blood flow (plethysmography)...
  34. Sue C Bodine; Fiscal Year: 2015
    ..to respond to increased loading and nutritional intake to restore muscle size following extended periods of bed rest or inactivity could accelerate the progression of age-associated muscle loss, and contribute to the loss of ..
  35. Samuel Waxman; Fiscal Year: 2015
    ..The disruption of PAH2 domain of Sin3 binding to a limited number of SID transcription factors including REST, MAD1, KLF-9, -10, -11, -13 and -16, UME6 and HBP predicts a more selective epigenetic effect than treatment with ..
  36. Omega-3 Fatty Acids, Neurohumoral Activation, and Human Heart Failure
    Kevin D Monahan; Fiscal Year: 2010
    ..To determine the effect of omega-3 fatty acid supplementation on: 1) muscle sympathetic nerve activity (MSNA) at rest and in response to baroreceptor loading/unloading in HF patients, 2) renal vasoconstrictor responses to baroreflex ..
  37. Jack L Feldman; Fiscal Year: 2016
    ..on the inspiratory phase while the expiratory period and its specific modulation during passive expiration at rest and active expiration in exercise have been overlooked...
  38. Shireen Saleque; Fiscal Year: 2014
    ..recent findings linking Gfi-1 and Gfi-1b to chromatin modifiers LSD1 (lysine specific demethylase1), CoREST/Rcor1 (REST co-repressor), other Rcor homologs and the histone deacetylases HDAC1-2, we propose to explore the role of these co-..
  39. Mediator and epigenetic control of neuronal gene expression and differentiation
    Thomas G Boyer; Fiscal Year: 2013
    ..for epigenetic silencing imposed by the RE1 silencing transcription factor/neuron restrictive silencing factor (REST/NRSF), a key determinant of neuronal fate that suppresses neuronal gene expression in non-neuronal and neural ..
  40. Sex Differences in Myocardial Ischemia Triggered by Emotional Factors after MI
    Viola Vaccarino; Fiscal Year: 2010
    ..emission tomography (SPECT) [Tc-99m] sestamibi myocardial perfusion imaging, to compare myocardial perfusion during rest, during exercise, and during an emotionally stressful challenge in women and men...
  41. Effects of Dietary Fat on Contractile and Mitochondrial Function in Heart Failure
    Margaret P Chandler; Fiscal Year: 2010
    ..will examine the effects of high fat diets (saturated and unsaturated) on myocardial contractile function (both at rest and under conditions of high workload), and mitochondrial OX PHOS and ETC complex activities in normal rats and in ..
  42. Jeanie Park; Fiscal Year: 2014
    ..test the effects of oral BH4 treatment on SNS overactivity, endothelial dysfunction, and oxidative stress, both at rest and during exercise in CRF patients...
  43. Sex-specific gene regulation of neuronal chloride co-transporter, kcc2
    WOLFGANG B LIEDTKE; Fiscal Year: 2010
    ..We have obtained exciting preliminary results (1) showing that kcc2 transcription is regulated by the repressor REST/NRSF which binds to a novel RE1/NRSE DNA binding site in kcc2 regulatory regions, (2) demonstrating this regulation ..
  44. Modular Subunit Vaccine for Salmonella
    MARC KEVIN JENKINS; Fiscal Year: 2011
    ..stimulation by STpMHCII+ phagocytes in the lymphoid organs harboring infected phagocytes interspersed by periods of rest in uninfected tissues is involved...
  45. Genes required for lipid processing and digestive organ function in larval zebraf
    Steven A Farber; Fiscal Year: 2011
    ..and transport of fatty acids (FA) in vivo, such as their uptake from the intestinal lumen and secretion to the rest of the body, are not fully understood...
  46. Viola Vaccarino; Fiscal Year: 2016
    ..emission tomography (SPECT) [Tc-99m]sestamibi imaging of myocardial perfusion, compare myocardial perfusion at rest, during mental stress and during exercise stress between women and men less than 60 years old who were hospitalized ..
  47. Sympathetic Nervous System and Heart Failure-Role of Primary Afferent Neurons
    Jianhua Li; Fiscal Year: 2010
    ..Sympathetic nervous activity (SNA) is increased with exercise in normal subjects and is increased in HF patients at rest and in response to exercise...
  48. Obesity, vascular inflammation, and immune cell activation in prehypertension
    Suzi Hong; Fiscal Year: 2013
    ..on immune cells, cytokine producing cells upon antigen stimulation, and neutrophil oxidative burst, not only at rest but also in response to psychological and physical stressors...
  49. JORG BUNGERT; Fiscal Year: 2016
    ..We will map accessibility in the LCR and the rest of the 2-globin gene locus during differentiation using a novel approach, called MAPit, designed to assay protein ..
  50. Tumorigenic role of mitochondria in African-American women
    Keshav K Singh; Fiscal Year: 2011
    ..The rest are encoded by nuclear DNA (nDNA)...
  51. Evangelia G Kranias; Fiscal Year: 2016
    ..suggesting that perturbations in the levels or activity of a single protein in this network will influence the rest of the partners, eliciting amplification of its effects...
  52. The role of Immunoglobulin CDRH3 in Autoimmune Disease
    HARRY WILLIAM SCHROEDER; Fiscal Year: 2010
    ..The second will contain a single, normal DH as a control for the loss of the rest of the DH locus...
  53. Hirak S Basu; Fiscal Year: 2014
    ..Many of them, however, may remain indolent for the rest of the patients'life...
  54. Hongjun Wang; Fiscal Year: 2014
    ..independent (compared to >85% pre-operatively), 19% require minimal insulin (<10u/day) replacement and the rest develop pancreatogenic diabetes after surgery...
  55. Reduced contractile reserve: a therapeutic target in heart failure with normal EF
    Nancy K Sweitzer; Fiscal Year: 2012
    ..stress, despite the consistent clinical presentation of impaired exercise tolerance with few symptoms at rest. This study explores the multifactorial physiology of HFpEF, with a detailed investigation of the specificity of ..
  56. R Suzanne Zukin; Fiscal Year: 2016
    ..b>REST (repressor element 1 silencing transcription factor) is a gene silencing transcription factor that is widely ..
  57. Carolyn E Come; Fiscal Year: 2016
    ..that distribution varies with changes in lung volumes and further, relates to cardiac chamber size and function at rest and during exercise in normals and in patients with different levels of COPD severity...
  58. Role of Acid-Sensing Ion Channels in Pulmonary Vascular Smooth Muscle Store-Opera
    Nikki L Jernigan; Fiscal Year: 2012
    ..Lay Relevance: The pressure in the pulmonary circulation is relatively low compared to the rest of the body...
  59. The XXII nd North American Testis Workshop
    WILLIAM WALLACE WRIGHT; Fiscal Year: 2013
    ..The rest of the funds will defray part of the housing costs for the 20 distinguished scientists who have been invited to ..
  60. Climate Change and Health: Assessing the Risk of Preterm Delivery
    Rupa Basu; Fiscal Year: 2013
    ..cause of infant mortality and morbidity and among the top public health challenges facing our nation as well as the rest of the world. Yet the etiology remains largely unknown...
  61. Susan S Girdler; Fiscal Year: 2016
    ..laboratory (before and after the intervention), predicted biological mediators of MBSR efficacy will be assessed at rest and in response to mental stress: 1) sympathetic nervous system (blood pressure, heart rate, plasma norepinephrine ..
  62. Andreas Schmid; Fiscal Year: 2014
    ..The rest of the aims will then be pursued during the independent phase bringing me closer to my long- term goal of becoming ..
  63. Development of Experimental and Computational Models for Traumatic Aortic Rupture
    Kurosh Darvish; Fiscal Year: 2009
    ..The lungs will be represented by compressible foams and the rest of the space will be filled 10% gelatin and saline to hold the specimen in place...
  64. Sleep Patterns and Depression in Mothers and Fathers of Twins
    ELIZABETH DAMATO; Fiscal Year: 2007
    ..in Mothers and Fathers of Twins The demands of early parenthood and their impact on the ability to obtain rest and sleep are exponentially high for parents of twins...
  65. Integrative Cardiovascular Control During Exercise in Hypertension
    DONAL S O apos LEARY; Fiscal Year: 2010
    ..Although, it is known that hypertension impairs baroreflex function at rest, whether exercise further alters baroreflex function in hypertension is unknown...
  66. GENETIC ANALYSIS OF PAROXYSMAL DYSTONIC CHOREOATHETOSIS
    John Fink; Fiscal Year: 2000
    ..PDC), an inherited disorder characterized by attacks of involuntary movements that occur spontaneously at rest and often following caffeine or alcohol consumption...
  67. Arterial Baroreflex Function in African Americans at Rest and During Exercise
    David Keller; Fiscal Year: 2009
    ..are impaired in African Americans at rest and during exercise compared to age, gender and fitness-matched Caucasian American counterparts...
  68. The UAB Spina Bifida Patient Registry Demonstration Project
    David B Joseph; Fiscal Year: 2010
    ..7 out of every 10,000 live births in the United States and although this number seems to be going down in the rest of the country that is not necessarily true in Alabama...
  69. Pupil Size and Circadian Salivary Variations in Autism Spectrum Disorder
    JOHN A COLOMBO; Fiscal Year: 2010
    ..The tasks include measurement of (a) pupil size at rest, and (b) daytime variations in salivary measures of cortisol and alpha-amylase across two days...
  70. Novel device for improving standard CPR outcomes
    Keith Lurie; Fiscal Year: 2007
    ..to decrease the decompression phase intrathoracic pressure, creating a vacuum within the thorax relative to the rest of the body, thereby a) enhancing blood return to the thorax, b) enhancing blood return to the brain, c) providing ..
  71. Structural Basis for Bridged Bimetallic Enzyme Catalysis
    Dagmar Ringe; Fiscal Year: 2009
    ..the general features common to all bridged bimetalloenzyme mechanisms as well as the specific effects of the rest of the protein on the chemistry of the metal cluster...
  72. CHEMORECEPTOR ACTIVITY OF THE CAROTID BODY
    Carlos Eyzaguirre; Fiscal Year: 1990
    ..ACh, dopamine and neuropeptides during sensory stimulation and one should analyze their membrane properties at rest and during secretory activity; 3) It is possible to study how released or applied transmitters affect the membrane ..
  73. Sleep Therapy Headset for Improving Sleep Quality of Older Adults
    PHILIP BONELLO; Fiscal Year: 2007
    ..1997; Figueiro et al., 2002, 2005), consolidating their rest/activity rhythms and improving sleep efficiency at night...
  74. Completely Digitizing the Custom-Fit Hearing Aid Shell Manufacturing Process
    STEVEN YI; Fiscal Year: 2010
    ..world who need hearing aids, less than 20 percent of people in developed countries and less than 1 percent of the rest actually have hearing aids...
  75. Circuit Weight Training and Blood Pressure Regulation in Prehypertension
    William Cooke; Fiscal Year: 2007
    ..Circuit weight training is a specific type of resistance training that incorporates light weights and short rest intervals, and results in beneficial cardiorespiratory and musculoskeletal adaptations...
  76. Stress and Neuroimmune Dysergulation in Chronic Fatigue Patients
    Kathleen Light; Fiscal Year: 2007
    ..The principal symptom of CFS is severe persistent fatigue unrelieved by rest, with a worsening of fatigue and pain symptoms after exercise or stress that persists more than 24 hours...
  77. CONTROL OF SODIUM INTAKE IN THE HINDLIMB UNWEIGHTED RAT
    J Cunningham; Fiscal Year: 2005
    DESCRIPTION (Verbatim from the application): In the hind limb unweighted (HU) rat model of bed rest and microgravity, HU results in a central movement of body fluid, diuresis and natriuresis, resulting in a decrease in plasma volume...
  78. Neural Circulatory Control in the Long QT Syndrome
    Virend Somers; Fiscal Year: 2006
    ..Excitement and auditory stimuli typically trigger events in LQT2 patients. Most events in LQT3 occur at rest. This interaction between genotype, QT, autonomic status and environment is unclear...