cardiopulmonary resuscitation

Summary

Summary: The artificial substitution of heart and lung action as indicated for HEART ARREST resulting from electric shock, DROWNING, respiratory arrest, or other causes. The two major components of cardiopulmonary resuscitation are artificial ventilation (RESPIRATION, ARTIFICIAL) and closed-chest CARDIAC MASSAGE.

Top Publications

  1. pmc Chest compression fraction determines survival in patients with out-of-hospital ventricular fibrillation
    Jim Christenson
    MSc, Emergency and Health Services Commission of British Columbia, 302 2955 Virtual Way, Vancouver, British Columbia, Canada V5M 4X6
    Circulation 120:1241-7. 2009
  2. ncbi Prehospital epinephrine use and survival among patients with out-of-hospital cardiac arrest
    Akihito Hagihara
    Kyushu University Graduate School of Medicine, Department of Health Services Management and Policy, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    JAMA 307:1161-8. 2012
  3. ncbi YouTube as a source of information on cardiopulmonary resuscitation
    Karthik Murugiah
    Department of Medicine, AECOM Jacobi Medical Center, Bronx, NY, United States
    Resuscitation 82:332-4. 2011
  4. ncbi Cardiac arrest and cardiopulmonary resuscitation outcome reports: update and simplification of the Utstein templates for resuscitation registries: a statement for healthcare professionals from a task force of the International Liaison Committee on Resusci
    Ian Jacobs
    Circulation 110:3385-97. 2004
  5. ncbi Predictors of survival from out-of-hospital cardiac arrest: a systematic review and meta-analysis
    Comilla Sasson
    Departments of Emergency Medicine and Internal Medicine, University of Michigan, Ann Arbor, MI, USA
    Circ Cardiovasc Qual Outcomes 3:63-81. 2010
  6. pmc Perishock pause: an independent predictor of survival from out-of-hospital shockable cardiac arrest
    Sheldon Cheskes
    University of Toronto, Toronto, ON, Canada
    Circulation 124:58-66. 2011
  7. ncbi Quality of cardiopulmonary resuscitation during out-of-hospital cardiac arrest
    Lars Wik
    National Competence Center for Emergency Medicine, Ulleval University Hospital, Oslo, Norway
    JAMA 293:299-304. 2005
  8. pmc Cardiopulmonary resuscitation training in high school using avatars in virtual worlds: an international feasibility study
    Johan Creutzfeldt
    Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden
    J Med Internet Res 15:e9. 2013
  9. pmc Inhaled nitric oxide improves outcomes after successful cardiopulmonary resuscitation in mice
    Shizuka Minamishima
    Anesthesia Center for Critical Care Research of the Department of Anesthesia, Critical Care, and Pain Medicine, Ghent University, Ghent, Belgium
    Circulation 124:1645-53. 2011
  10. pmc Exploring virtual worlds for scenario-based repeated team training of cardiopulmonary resuscitation in medical students
    Johan Creutzfeldt
    Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden
    J Med Internet Res 12:e38. 2010

Detail Information

Publications365 found, 100 shown here

  1. pmc Chest compression fraction determines survival in patients with out-of-hospital ventricular fibrillation
    Jim Christenson
    MSc, Emergency and Health Services Commission of British Columbia, 302 2955 Virtual Way, Vancouver, British Columbia, Canada V5M 4X6
    Circulation 120:1241-7. 2009
    Quality cardiopulmonary resuscitation contributes to cardiac arrest survival...
  2. ncbi Prehospital epinephrine use and survival among patients with out-of-hospital cardiac arrest
    Akihito Hagihara
    Kyushu University Graduate School of Medicine, Department of Health Services Management and Policy, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    JAMA 307:1161-8. 2012
    Epinephrine is widely used in cardiopulmonary resuscitation for out-of-hospital cardiac arrest (OHCA). However, the effectiveness of epinephrine use before hospital arrival has not been established.
  3. ncbi YouTube as a source of information on cardiopulmonary resuscitation
    Karthik Murugiah
    Department of Medicine, AECOM Jacobi Medical Center, Bronx, NY, United States
    Resuscitation 82:332-4. 2011
    Widespread knowledge of cardiopulmonary resuscitation (CPR) is critical to improving survival in sudden cardiac death...
  4. ncbi Cardiac arrest and cardiopulmonary resuscitation outcome reports: update and simplification of the Utstein templates for resuscitation registries: a statement for healthcare professionals from a task force of the International Liaison Committee on Resusci
    Ian Jacobs
    Circulation 110:3385-97. 2004
    Outcome after cardiac arrest and cardiopulmonary resuscitation is dependent on critical interventions, particularly early defibrillation, effective chest compressions, and advanced life support...
  5. ncbi Predictors of survival from out-of-hospital cardiac arrest: a systematic review and meta-analysis
    Comilla Sasson
    Departments of Emergency Medicine and Internal Medicine, University of Michigan, Ann Arbor, MI, USA
    Circ Cardiovasc Qual Outcomes 3:63-81. 2010
    ..factors (event witnessed by a bystander or emergency medical services [EMS], provision of bystander cardiopulmonary resuscitation [CPR], initial cardiac rhythm, or the return of spontaneous circulation)...
  6. pmc Perishock pause: an independent predictor of survival from out-of-hospital shockable cardiac arrest
    Sheldon Cheskes
    University of Toronto, Toronto, ON, Canada
    Circulation 124:58-66. 2011
    ..Perishock pauses are pauses in chest compressions before and after defibrillatory shock. We examined the relationship between perishock pauses and survival to hospital discharge...
  7. ncbi Quality of cardiopulmonary resuscitation during out-of-hospital cardiac arrest
    Lars Wik
    National Competence Center for Emergency Medicine, Ulleval University Hospital, Oslo, Norway
    JAMA 293:299-304. 2005
    b>Cardiopulmonary resuscitation (CPR) guidelines recommend target values for compressions, ventilations, and CPR-free intervals allowed for rhythm analysis and defibrillation...
  8. pmc Cardiopulmonary resuscitation training in high school using avatars in virtual worlds: an international feasibility study
    Johan Creutzfeldt
    Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden
    J Med Internet Res 15:e9. 2013
    ..Less than 30% of out-of-hospital victims receive cardiopulmonary resuscitation (CPR) despite the American Heart Association training over 12 million laypersons annually to conduct ..
  9. pmc Inhaled nitric oxide improves outcomes after successful cardiopulmonary resuscitation in mice
    Shizuka Minamishima
    Anesthesia Center for Critical Care Research of the Department of Anesthesia, Critical Care, and Pain Medicine, Ghent University, Ghent, Belgium
    Circulation 124:1645-53. 2011
    ..Breathing nitric oxide (NO) reduces ischemia/reperfusion injury in animal models and in patients. The objective of this study was to learn whether inhaled NO improves outcomes after CA and cardiopulmonary resuscitation (CPR).
  10. pmc Exploring virtual worlds for scenario-based repeated team training of cardiopulmonary resuscitation in medical students
    Johan Creutzfeldt
    Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden
    J Med Internet Res 12:e38. 2010
    ..b>Cardiopulmonary resuscitation (CPR) is a field within medicine in high demand for new and effective training modalities.
  11. ncbi The incidence of regurgitation during cardiopulmonary resuscitation: a comparison between the bag valve mask and laryngeal mask airway
    B J Stone
    Department of Resuscitation, Conquest Hospital, Hastings, E Sussex, UK
    Resuscitation 38:3-6. 1998
    ..The resuscitation data collection forms of 996 patients who underwent in-hospital cardiopulmonary resuscitation over a 3.5 year period were reviewed...
  12. ncbi Cardiopulmonary resuscitation with assisted extracorporeal life-support versus conventional cardiopulmonary resuscitation in adults with in-hospital cardiac arrest: an observational study and propensity analysis
    Yih Sharng Chen
    Department of Surgery, National Taiwan University Hospital, Taipei, Taiwan
    Lancet 372:554-61. 2008
    ..However, there is little evidence about the benefit of the procedure compared with conventional cardiopulmonary resuscitation (CPR), especially when continued for more than 10 min...
  13. ncbi Estimating effectiveness of cardiac arrest interventions: a logistic regression survival model
    T D Valenzuela
    Department of Surgery, University of Arizona, Tucson, USA
    Circulation 96:3308-13. 1997
    ..The study objective was to develop a simple, generalizable predictive model for survival after out-of-hospital cardiac arrest due to ventricular fibrillation...
  14. ncbi Chest compression rates during cardiopulmonary resuscitation are suboptimal: a prospective study during in-hospital cardiac arrest
    Benjamin S Abella
    Emergency Resuscitation Center and Section of Emergency Medicine, University of Chicago Hospitals, Chicago, Ill 60637, USA
    Circulation 111:428-34. 2005
    Recent data highlight a vital link between well-performed cardiopulmonary resuscitation (CPR) and survival after cardiac arrest; however, the quality of CPR as actually performed by trained healthcare providers is largely unknown...
  15. pmc What is the role of chest compression depth during out-of-hospital cardiac arrest resuscitation?
    Ian G Stiell
    Department of Emergency Medicine and Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Ontario, Canada
    Crit Care Med 40:1192-8. 2012
    The 2010 international guidelines for cardiopulmonary resuscitation recently recommended an increase in the minimum compression depth from 38 to 50 mm, although there are limited human data to support this...
  16. ncbi CPR training and CPR performance: do CPR-trained bystanders perform CPR?
    Robert Swor
    Department of Emergency Medicine, Royal Oak William Beaumont Hospital, Royal Oak, MI, USA
    Acad Emerg Med 13:596-601. 2006
    To determine factors associated with cardiopulmonary resuscitation (CPR) provision by CPR-trained bystanders and to determine factors associated with CPR performance by trained bystanders.
  17. ncbi Comparison of the efficacy of nifekalant and amiodarone in a porcine model of cardiac arrest
    Xian Fei Ji
    Department of Emergency, Beijing Chaoyang Hospital, Capital Medical University, 8 Baijiazhuang Road, Chaoyang District, Beijing 100020, China
    Resuscitation 81:1031-6. 2010
    ..To compare the efficacy of nifekalant and amiodarone in the treatment of cardiac arrest in a porcine model...
  18. ncbi Effect of chest compressions on the time taken to insert airway devices in a manikin
    J J Gatward
    Department of Anaesthesia, Royal United Hospital, Combe Park, Bath BA1 3NG, UK
    Br J Anaesth 100:351-6. 2008
    ..This study was designed to evaluate the speed with which different airway devices could be placed with and without interrupting chest compressions...
  19. ncbi Neurologic prognostication and bispectral index monitoring after resuscitation from cardiac arrest
    Marion Leary
    Center for Resuscitation Science and Department of Emergency Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Resuscitation 81:1133-7. 2010
    ..We hypothesized that BIS values within 24 h after resuscitation would correlate with neurologic outcomes at discharge...
  20. ncbi CPR knowledge and attitude to performing bystander CPR among secondary school students in Norway
    B K Kanstad
    Faculty of Health Sciences, University of Tromsø, 9037 Tromsø, Norway
    Resuscitation 82:1053-9. 2011
    Early bystander cardiopulmonary resuscitation (CPR) is essential for survival from out-of-hospital cardiac arrest (OHCA)...
  21. ncbi Conventional and chest-compression-only cardiopulmonary resuscitation by bystanders for children who have out-of-hospital cardiac arrests: a prospective, nationwide, population-based cohort study
    Tetsuhisa Kitamura
    Kyoto University Health Service, Kyoto, Japan
    Lancet 375:1347-54. 2010
    The American Heart Association recommends cardiopulmonary resuscitation (CPR) by bystanders with chest compression only for adults who have cardiac arrests, but not for children...
  22. ncbi Global incidences of out-of-hospital cardiac arrest and survival rates: Systematic review of 67 prospective studies
    Jocelyn Berdowski
    Department of Cardiology, Academic Medical Centre University of Amsterdam, Amsterdam, The Netherlands
    Resuscitation 81:1479-87. 2010
    ..The aim of this investigation was to estimate and contrast the global incidence and outcome of out-of-hospital cardiac arrest (OHCA) to provide a better understanding of the variability in risk and survival of OHCA...
  23. ncbi Cardiac arrest with cardiopulmonary resuscitation reduces dendritic spine density in CA1 pyramidal cells and selectively alters acquisition of spatial memory
    Gretchen N Neigh
    Department of Psychology, Townshend Hall, 1885 Neil Avenue Mall, The Ohio State University, Columbus, OH 43210, USA
    Eur J Neurosci 20:1865-72. 2004
    ..maze to characterize spatial learning and memory deficits elicited by 8 min of cardiac arrest with cardiopulmonary resuscitation (CA/CPR) in mice, which is associated with a 25-50% decrease in CA1 neurons...
  24. ncbi Identifying potentially shockable rhythms without interrupting cardiopulmonary resuscitation
    Yongqin Li
    Weil Institute of Critical Care Medicine, Rancho Mirage, CA, USA
    Crit Care Med 36:198-203. 2008
    ..Interruption of chest compressions reduces likelihood of successful resuscitation by as much as 50%. We sought a method to identify a shockable rhythm without interrupting chest compressions during cardiopulmonary resuscitation (CPR).
  25. ncbi How best to teach CPR to schoolchildren: a systematic review
    Nina Plant
    Department of Anesthesiology and Pain Medicine, Hospital for Sick Children, Toronto, Canada
    Resuscitation 84:415-21. 2013
    Training schoolchildren to perform cardiopulmonary resuscitation is one possible method of increasing bystander CPR rates. We reviewed available literature to identify what methods of training children have been successful.
  26. ncbi Perceived stress and team performance during a simulated resuscitation
    Sabina Hunziker
    Department of Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Intensive Care Med 37:1473-9. 2011
    Barriers to optimal performance of cardiopulmonary resuscitation may partly relate to human factors, such as stress and specific emotions...
  27. ncbi Long-term prognosis after out-of-hospital cardiac arrest
    Tina I Horsted
    Department of Anaesthesia, Centre of Head and Orthopaedics 4231, Copenhagen University Hospital, Rigshospitalet, DK 2100 Copenhagen, Denmark
    Resuscitation 72:214-8. 2007
    ..In this study we aimed to report survival beyond 6 months, including quality of life, for patients after out-of-hospital cardiac arrest (OHCA) with a physician-based EMS in an urban area...
  28. ncbi Effectiveness of emergency response planning for sudden cardiac arrest in United States high schools with automated external defibrillators
    Jonathan A Drezner
    Associate Professor, Department of Family Medicine, 4245 Roosevelt Way NE, University of Washington, Box 354775, Seattle, WA 98105, USA
    Circulation 120:518-25. 2009
    ..We analyzed the effectiveness of emergency response planning for sudden cardiac arrest (SCA) in a large cohort of US high schools that had onsite AED programs...
  29. ncbi Sports-related sudden death in the general population
    Eloi Marijon
    Paris Cardiovascular Research Center, INSERM U970, Hopital Europeen Georges Pompidou, Paris Cedex 15, France
    Circulation 124:672-81. 2011
    ..Although such data are available for young competitive athletes, the prevalence, characteristics, and outcome of sports-related sudden death have not been assessed previously in the general population...
  30. ncbi Incidence of EMS-treated out-of-hospital cardiac arrest in Europe
    Christie Atwood
    School of Medicine, University of Washington, Seattle, WA 98104, USA
    Resuscitation 67:75-80. 2005
    ..The aim of the investigation was to determine a representative European incidence and survival from cardiac arrest in all-rhythms and in ventricular fibrillation treated by the emergency medical services (EMS)...
  31. ncbi Outcome of patients with profound cardiogenic shock after cardiopulmonary resuscitation and prompt extracorporeal membrane oxygenation support. A single-center observational study
    Sheng Ying Chung
    Division of Cardiology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan
    Circ J 76:1385-92. 2012
    ..The in-hospital outcome of patients with profound cardiogenic shock (CS) undergoing extracorporeal membrane oxygenation (ECMO) and prognostic predictors were analyzed...
  32. ncbi Suppression of the cardiopulmonary resuscitation artefacts using the instantaneous chest compression rate extracted from the thoracic impedance
    E Aramendi
    Electronics and Telecommunications Department, University of the Basque Country, Alameda Urquijo s n, 48013 Bilbao, Spain
    Resuscitation 83:692-8. 2012
    ..demonstrate that the instantaneous chest compression rate can be accurately estimated from the transthoracic impedance (TTI), and that this estimated rate can be used in a method to suppress cardiopulmonary resuscitation (CPR) artefacts.
  33. ncbi Undergraduate nursing students' acquisition and retention of CPR knowledge and skills
    Catherine Madden
    Department of Nursing, Waterford Institute of Technology, Cork Road, Waterford, Republic of Ireland
    Nurse Educ Today 26:218-27. 2006
    ..a cardiac arrest situation rests on nurses being competent in the emergency life-saving procedure of cardiopulmonary resuscitation (CPR)...
  34. ncbi Assessment of BLS skills: optimizing use of instructor and manikin measures
    Bonnie Lynch
    University of Dundee School of Medicine, Dundee, Tayside Centre for General Practice, Mackenzie Building, Kirsty Semple Way, Dundee DD2 4BF, United Kingdom
    Resuscitation 76:233-43. 2008
    ..Comparisons of instructors' subjective assessments with objective data from recording manikins provide one means of understanding the magnitude and type of instructor errors in assessment...
  35. ncbi Subarachnoid haemorrhage as a cause of out-of-hospital cardiac arrest: a prospective computed tomography study
    Joji Inamasu
    Department of Emergency Medicine, Saiseikai Utsunomiya Hospital, Utsunomiya, Japan
    Resuscitation 80:977-80. 2009
    ..Early identification of SAH-induced OHCA with the use of brain computed tomography (CT) scan obtained immediately after resuscitation may help emergency physicians make therapeutic decision as quickly as they can...
  36. ncbi The impact of a new CPR assist device on rate of return of spontaneous circulation in out-of-hospital cardiac arrest
    Michael Casner
    San Francisco Fire Department, San Francisco, California 94107, USA
    Prehosp Emerg Care 9:61-7. 2005
    ..A retrospective chart review was undertaken to determine whether the AutoPulse had altered short-term patient outcome, specifically, return of spontaneous circulation (ROSC)...
  37. pmc Communication and decision making about life-sustaining treatment: examining the experiences of resident physicians and seriously-ill hospitalized patients
    Kristy S Deep
    Department of Internal Medicine, University of Kentucky College of Medicine, Lexington, KY 40536, USA
    J Gen Intern Med 23:1877-82. 2008
    ..Few prior studies have examined these conversations qualitatively to uncover why ineffective communication styles may persist...
  38. ncbi Quality of chest compressions during 10min of single-rescuer basic life support with different compression: ventilation ratios in a manikin model
    Conrad Arnfinn Bjørshol
    Department of Anaesthesia and Intensive Care, Division of Acute Care Medicine, Stavanger University Hospital, Stavanger, Norway
    Resuscitation 77:95-100. 2008
    ..As fatigue may reduce BLS performance over time we wanted to examine the quality of chest compressions in a single-rescuer scenario during prolonged BLS with different compression:ventilation ratios (C:V ratios)...
  39. pmc Rationale, development and implementation of the Resuscitation Outcomes Consortium Epistry-Cardiac Arrest
    Laurie J Morrison
    Prehospital and Transport Medicine Research Program, Sunnybrook and Women s College Health Sciences Centre, 2075 Bayview Avenue, Suite C753, Toronto, Ontario, Canada M4N 3M5
    Resuscitation 78:161-9. 2008
    ..To describe the development, design and consequent scientific implications of the Resuscitation Outcomes Consortium (ROC) population-based registry; ROC Epistry-Cardiac Arrest...
  40. ncbi Uniform reporting of measured quality of cardiopulmonary resuscitation (CPR)
    Jo Kramer-Johansen
    Institute for Experimental Medical Research, Ullevaal University Hospital, N 0407 Oslo, Norway
    Resuscitation 74:406-17. 2007
    ..This will allow for meaningful comparisons between treatment groups in clinical trials as well as a common system for quality improvement and documentation of this improvement...
  41. ncbi Education in resuscitation: an ILCOR symposium: Utstein Abbey: Stavanger, Norway: June 22-24, 2001
    Douglas A Chamberlain
    Circulation 108:2575-94. 2003
  42. ncbi Improving in-hospital cardiac arrest process and outcomes with performance debriefing
    Dana P Edelson
    Section of General Internal Medicine, University of Chicago, Chicago, Illinois, USA
    Arch Intern Med 168:1063-9. 2008
    Recent investigations have documented poor cardiopulmonary resuscitation (CPR) performance in clinical practice...
  43. ncbi A reliable and valid method for evaluating cardiopulmonary resuscitation training outcomes
    R T Brennan
    Harvard University, Graduate School of Education, Department of Administration, Cambridge, MA 02138, USA
    Resuscitation 32:85-93. 1996
    ..92). We urge standardized reporting of CPR training outcomes in order to achieve comparability across studies...
  44. pmc Hypothermia and postconditioning after cardiopulmonary resuscitation reduce cardiac dysfunction by modulating inflammation, apoptosis and remodeling
    Patrick Meybohm
    Department of Anaesthesiology and Intensive Care Medicine, University Hospital Schleswig Holstein, Kiel, Germany
    PLoS ONE 4:e7588. 2009
    ..This study sought to examine whether hypothermia and the combination of hypothermia and pharmacological postconditioning are cardioprotective in a model of cardiopulmonary resuscitation following acute myocardial ischemia.
  45. ncbi Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia
    Stephen A Bernard
    Intensive Care Unit, Dandenong Hospital, Dandenong, Australia
    N Engl J Med 346:557-63. 2002
    ..In a randomized, controlled trial, we compared the effects of moderate hypothermia and normothermia in patients who remained unconscious after resuscitation from out-of-hospital cardiac arrest...
  46. pmc Chest-compression-only versus standard cardiopulmonary resuscitation: a meta-analysis
    Michael Hüpfl
    Department of Anesthesiology, Critical Care and Pain Therapy, Medical University of Vienna, Vienna, Austria
    Lancet 376:1552-7. 2010
    ..We aimed to establish the association of chest-compression-only CPR with survival in patients with out-of-hospital cardiac arrest...
  47. ncbi Manual chest compression vs use of an automated chest compression device during resuscitation following out-of-hospital cardiac arrest: a randomized trial
    Al Hallstrom
    Department of Biostatistics, University of Washington, Seattle, WA 98105, USA
    JAMA 295:2620-8. 2006
    High-quality cardiopulmonary resuscitation (CPR) may improve both cardiac and brain resuscitation following cardiac arrest...
  48. ncbi Vasopressin and epinephrine vs. epinephrine alone in cardiopulmonary resuscitation
    Pierre Yves Gueugniaud
    Service d Aide Médicale Urgente 69, Hospices Civils de Lyon, University of Lyon 1, Lyon, France
    N Engl J Med 359:21-30. 2008
    ....
  49. pmc Characteristics and outcome among patients having out of hospital cardiac arrest at home compared with elsewhere
    J Herlitz
    Division of Cardiology, Sahlgrenska University Hospital, Goteborg, Sweden
    Heart 88:579-82. 2002
    ..To describe the characteristics and outcome of patients who have a cardiac arrest at home compared with elsewhere out of hospital...
  50. pmc Anxiety after cardiac arrest/cardiopulmonary resuscitation: exacerbated by stress and prevented by minocycline
    Gretchen N Neigh
    Department of Psychology, The Ohio State University, Columbus, Ohio 30322, USA
    Stroke 40:3601-7. 2009
    ..The goal of this study was to determine the effects of prior exposure to chronic stress on ischemia-induced neuronal death, microglial activation, and anxiety-like behavior...
  51. ncbi Intravenous drug administration during out-of-hospital cardiac arrest: a randomized trial
    Theresa M Olasveengen
    Institute for Experimental Medical Research, Oslo University Hospital, Ullevaal, N 0407 Oslo, Norway
    JAMA 302:2222-9. 2009
    ..an independent predictor of poor outcome in a large epidemiological study, possibly due to toxicity of the drug or cardiopulmonary resuscitation (CPR) interruptions secondary to establishing an intravenous line and drug administration.
  52. pmc Early versus later rhythm analysis in patients with out-of-hospital cardiac arrest
    Ian G Stiell
    Department of Emergency Medicine and Ottawa Hospital Research Institute, University of Ottawa, Ottawa
    N Engl J Med 365:787-97. 2011
    ..on Resuscitation suggested that emergency medical service (EMS) personnel could provide 2 minutes of cardiopulmonary resuscitation (CPR) before the first analysis of cardiac rhythm...
  53. ncbi Impact of adding video communication to dispatch instructions on the quality of rescue breathing in simulated cardiac arrests--a randomized controlled study
    Chih Wei Yang
    Department of Emergency Medicine, National Taiwan University Hospital, Taipei, Taiwan Department of Medical Education, National Taiwan University Hospital, Taipei, Taiwan
    Resuscitation 78:327-32. 2008
    Both ventilations and compressions are important for victims of prolonged cardiopulmonary resuscitation (CPR) and asphyxial arrest...
  54. ncbi Use of an automated, load-distributing band chest compression device for out-of-hospital cardiac arrest resuscitation
    Marcus Eng Hock Ong
    Department of Epidemiology and Community Health, Virginia Commonwealth University, Richmond, USA
    JAMA 295:2629-37. 2006
    ..Only 1% to 8% of adults with out-of-hospital cardiac arrest survive to hospital discharge...
  55. ncbi Effect of continuous compressions and 30:2 cardiopulmonary resuscitation on global ventilation/perfusion values during resuscitation in a porcine model
    Shuo Wang
    Department of Emergency Medicine, Beijing Chaoyang Hospital affiliated with Capital Medical University, Beijing, China
    Crit Care Med 38:2024-30. 2010
    ..was undertaken to analyze the global ventilation/perfusion values of continuous compressions and 30:2 cardiopulmonary resuscitation to determine the effectiveness for each approach in a porcine model of prolonged bystander ..
  56. ncbi Quality of out-of-hospital cardiopulmonary resuscitation with real time automated feedback: a prospective interventional study
    Jo Kramer-Johansen
    Institute for Experimental Medical Research, University of Oslo, N 0407 Oslo, Norway
    Resuscitation 71:283-92. 2006
    ..To compare quality of CPR during out-of-hospital cardiac arrest with and without automated feedback...
  57. ncbi Observations and warning signs prior to cardiac arrest. Should a medical emergency team intervene earlier?
    J Nurmi
    Department of Anesthesiology and Intensive Care Medicine, Uusimaa Emergency Medical Services, Helsinki University Hospital, FI 00100 Helsinki, Finland
    Acta Anaesthesiol Scand 49:702-6. 2005
    ..Our aim was to analyze the effectiveness of observation practice to detect abnormalities in vital signs prior to cardiac arrest and to determine the need for a MET system in Finnish hospitals...
  58. ncbi Predictors of cardiopulmonary resuscitation and automated external defibrillator skill retention
    Barbara Riegel
    School of Nursing, University of Pennsylvania, Philadelphia, PA 19104 6096, USA
    Am Heart J 150:927-32. 2005
    Few data exist regarding the retention of cardiopulmonary resuscitation (CPR) and automated external defibrillator (AED) skills over time in relationship to characteristics of lay volunteer responders, training, or risk of exposure to ..
  59. ncbi Long-term prognosis after out-of-hospital cardiac arrest and primary percutaneous coronary intervention
    B Bendz
    Department of Cardiology, Ulleval University Hospital, N 0407 Oslo, Norway
    Resuscitation 63:49-53. 2004
    To study the long-term survival after out-of-hospital cardiac arrest and successful cardiopulmonary resuscitation (CPR) in patients with acute ST-segment elevation myocardial infarction (STEMI) treated with primary percutaneous coronary ..
  60. ncbi European nursing organizations stand up for family presence during cardiopulmonary resuscitation: a joint position statement
    Philip Moons
    Center for Health Services and Nursing Research, Catholic University of Leuven, Leuven, Belgium
    Prog Cardiovasc Nurs 23:136-9. 2008
    Empirical evidence suggests that family presence during cardiopulmonary resuscitation (CPR) has beneficial effects...
  61. ncbi Mechanical chest compressions and simultaneous defibrillation vs conventional cardiopulmonary resuscitation in out-of-hospital cardiac arrest: the LINC randomized trial
    Sten Rubertsson
    Department of Surgical Sciences Anaesthesiology and Intensive Care, Uppsala University, Uppsala, Sweden
    JAMA 311:53-61. 2014
    ..A strategy using mechanical chest compressions might improve the poor outcome in out-of-hospital cardiac arrest, but such a strategy has not been tested in large clinical trials...
  62. ncbi Impedance-based ventilation detection during cardiopulmonary resuscitation
    Martin Risdal
    Department of Electrical and Computer Engineering, University of Stavanger, Stavanger 4036, Norway
    IEEE Trans Biomed Eng 54:2237-45. 2007
    It has been suggested to develop automated external defibrillators with the ability to monitor cardiopulmonary resuscitation (CPR) performance online and give corrective feedback in order to improve the resuscitation quality...
  63. ncbi Dispatcher assisted CPR: implementation and potential benefit. A 12-year study
    Alfred P Hallstrom
    Department of Biostatistics, Clinical Trial Center, University of Washington, 1107 N E 45th St, Suite 505, Seattle, WA 98105 4689, USA
    Resuscitation 57:123-9. 2003
    Our objectives are to describe details of the dispatcher assisted cardiopulmonary resuscitation (CPR) instruction program we implemented during a 12 years study and to provide estimates of the potential number of out-of-hospital cardiac ..
  64. ncbi A comparison of 2 types of chest compressions in a porcine model of cardiac arrest
    Jun Yuan Wu
    Emergency Department, affiliated Chao Yang Hospital of Capital Medical University, Chao Yang District, Beijing 100020, China
    Am J Emerg Med 27:823-9. 2009
    ..This study was designed to compare the effects of these clinical quality chest compressions with standard manual chest compressions in a porcine model of cardiac arrest...
  65. ncbi Coagulopathy after successful cardiopulmonary resuscitation following cardiac arrest: implication of the protein C anticoagulant pathway
    Christophe Adrie
    Intensive Care Unit, Delafontaine Hospital, Saint Denis, France
    J Am Coll Cardiol 46:21-8. 2005
    ..We investigated coagulation abnormalities in out-of-hospital cardiac arrest (OHCA) patients, with special attention to the protein C anticoagulant pathway...
  66. pmc The impact of increased chest compression fraction on return of spontaneous circulation for out-of-hospital cardiac arrest patients not in ventricular fibrillation
    Christian Vaillancourt
    University of Ottawa, Ottawa Hospital Research Institute, Ottawa, ON, Canada
    Resuscitation 82:1501-7. 2011
    ..We evaluated the effect of CCF on return of spontaneous circulation (ROSC) in OOHCA patients with non-VF ECG rhythms in the Resuscitation Outcomes Consortium Epistry...
  67. ncbi Apolipoprotein E polymorphism: survival and neurological outcome after cardiopulmonary resuscitation
    M Schiefermeier
    Department of Clinical Neurology, University of Vienna, Vienna, Austria
    Stroke 31:2068-73. 2000
    ..The aim of this study was to determine whether the apoE 3/3 genotype has an impact on survival and neurological outcome after cardiopulmonary resuscitation.
  68. ncbi Monitoring intervention programmes for out-of-hospital cardiac arrest in a mixed urban and rural setting
    Andrea Fabbri
    Dipartimento dell Emergenza, Azienda USL Forlì, Italy
    Resuscitation 71:180-7. 2006
    ....
  69. ncbi Hypothermia for neuroprotection in adults after cardiopulmonary resuscitation
    Jasmin Arrich
    Department of Emergency Medicine, Medical University of Vienna, Vienna, Austria
    Cochrane Database Syst Rev 9:CD004128. 2012
    ..Experimental evidence suggests that therapeutic hypothermia is beneficial, and a number of clinical studies on this subject have been published. This review was originally published in 2009...
  70. ncbi Poor quality teaching in lay person CPR courses
    Melinda M Parnell
    Department of Surgery and Anaesthetics, Wellington School of Medicine, Wellington, New Zealand
    Resuscitation 73:271-8. 2007
    Recent studies have found that poor cardiopulmonary resuscitation (CPR) is commonly performed in resuscitation attempts, both by health professionals and lay people...
  71. ncbi Optimal oxygenation during and after cardiopulmonary resuscitation
    Robert W Neumar
    Center for Resuscitation Science and Department of Emergency Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Curr Opin Crit Care 17:236-40. 2011
    Reversal of tissue hypoxia, particularly in the heart and brain, is a fundamental goal of cardiopulmonary resuscitation. However, a growing body of evidence suggests that hyperoxia, especially after return of spontaneous circulation (..
  72. ncbi I guideline for cardiopulmonary resuscitation and emergency cardiovascular care -- Brazilian Society of Cardiology: executive summary
    Maria Margarita Gonzalez
    Sociedade Brasileira de Cardiologia, Rio de Janeiro, RJ, Brasil
    Arq Bras Cardiol 100:105-13. 2013
    ..mainly in the pre-hospital environment, with emphasis on the early recognition and delivery of cardiopulmonary resuscitation maneuvers focused on high-quality thoracic compressions and rapid defibrillation by means of the ..
  73. pmc Ventricular tachyarrhythmias after cardiac arrest in public versus at home
    Myron L Weisfeldt
    Johns Hopkins University, Baltimore, MD 21287, USA
    N Engl J Med 364:313-21. 2011
    ..We conducted a study to determine whether the location of the arrest, the type of arrhythmia, and the probability of survival are associated...
  74. ncbi Direct evaluation of the effect of filtering the chest compression artifacts on the uninterrupted cardiopulmonary resuscitation time
    Jesus Ruiz
    Department of Communications Engineering, University of the Basque Country UPV EHU, 48013 Bilbao, Spain
    Am J Emerg Med 31:910-5. 2013
    Filtering the cardiopulmonary resuscitation (CPR) artifact has been a major approach to minimizing interruptions to CPR for rhythm analysis. However, the effects of these filters on interruptions to CPR have not been evaluated...
  75. pmc Normoxic resuscitation after cardiac arrest protects against hippocampal oxidative stress, metabolic dysfunction, and neuronal death
    Viktoria Vereczki
    Department of Anesthesiology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Cereb Blood Flow Metab 26:821-35. 2006
    ..Moreover, these findings indicate the need for clinical trials comparing the effects of different ventilatory oxygen levels on neurologic outcome after cardiac arrest...
  76. ncbi Prognosis of coma after therapeutic hypothermia: a prospective cohort study
    Aline Bouwes
    Department of Intensive Care, Academic Medical Center, Amsterdam, The Netherlands
    Ann Neurol 71:206-12. 2012
    ..reliability of neurologic examination, neuron-specific enolase (NSE), and median nerve somatosensory-evoked potentials (SEPs) to predict poor outcome in patients treated with mild hypothermia after cardiopulmonary resuscitation (CPR).
  77. ncbi Cardiopulmonary resuscitation feedback improves the quality of chest compression provided by hospital health care professionals
    Charles N Pozner
    STRATUS Center for Medical Simulation, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Emerg Med 29:618-25. 2011
    ..Suboptimal in-hospital CC are commonly reported. Skill degradation and fatigue have been implicated. We assessed the effect of a handheld feedback device on the measured and perceived quality of CC and rescuer physiologic response...
  78. ncbi CPR with chest compression alone or with rescue breathing
    Thomas D Rea
    Emergency Medical Services Division of Public Health for Seattle and King County, Seattle, Washington, USA
    N Engl J Med 363:423-33. 2010
    The role of rescue breathing in cardiopulmonary resuscitation (CPR) performed by a layperson is uncertain...
  79. ncbi Methylene blue protects the cortical blood-brain barrier against ischemia/reperfusion-induced disruptions
    Adriana Miclescu
    Department of Surgical Sciences Anaesthesiology and Critical Care Medicine, Uppsala University, Uppsala, Sweden
    Crit Care Med 38:2199-206. 2010
    ..the effects of cardiac arrest and the reperfusion syndrome on blood-brain barrier permeability and evaluate whether methylene blue counteracts blood-brain barrier disruption in a pig model of controlled cardiopulmonary resuscitation.
  80. pmc Survey of junior hospital doctors' attitudes to cardiopulmonary resuscitation
    R Morgan
    Wirral Hospital NHS Trust, Arrowe Park Hospital, Wirral, Merseyside, UK
    Postgrad Med J 78:413-5. 2002
    Most cardiac arrest teams are made up of junior doctors. The stressful effect of cardiopulmonary resuscitation (CPR) on doctors has not previously been established...
  81. ncbi The chain of survival
    Jerry Nolan
    Department of Anaesthesia and Intensive Care Medicine, Royal United Hospital, Combe Park, Bath, Banes BA1 3NG, United Kingdom
    Resuscitation 71:270-1. 2006
  82. ncbi In-hospital cardiac arrest: survival depends mainly on the effectiveness of the emergency response
    Claudio Sandroni
    Department of Anaesthesiology and Intensive Care, Catholic University School of Medicine, Largo Gemelli 8, 00168 Rome, Italy
    Resuscitation 62:291-7. 2004
    ..To evaluate the factors affecting the outcome of in-hospital cardiac arrest...
  83. ncbi In-hospital cardiac arrest: incidence, prognosis and possible measures to improve survival
    Claudio Sandroni
    Intensive Care Unit, Catholic University School of Medicine, Rome, Italy
    Intensive Care Med 33:237-45. 2007
    ..Review...
  84. ncbi The quality of chest compressions during cardiopulmonary resuscitation overrides importance of timing of defibrillation
    Giuseppe Ristagno
    Weil Institute of Critical Care Medicine, 35100 Bob Hope Dr, Rancho Mirage, CA 92270, USA
    Chest 132:70-5. 2007
    ..We address the quality of chest compressions and the impact on initial defibrillation or initial chest compressions after sudden death...
  85. ncbi Effects of rescuer position on the kinematics of cardiopulmonary resuscitation (CPR) and the force of delivered compressions
    Chih Hsien Chi
    Department of Emergency Medicine, National Cheng Kung University, Tainan 70403, Taiwan
    Resuscitation 76:69-75. 2008
    ..The rescuer position may affect workload, and hence rate of fatigue and quality of CPR...
  86. ncbi Evaluating the quality of prehospital cardiopulmonary resuscitation by reviewing automated external defibrillator records and survival for out-of-hospital witnessed arrests
    Patrick Chow In Ko
    Department of Emergency Medicine, National Taiwan University Hospital, College of Medicine, National Taiwan University, No 7, Chung Shan S Rd, Taipei 100, Taiwan, ROC
    Resuscitation 64:163-9. 2005
    Without an easy method to monitor the performance of prehospital cardiopulmonary resuscitation (CPR), earlier studies have not been able to assess the quality of CPR...
  87. ncbi Feedback during cardiopulmonary resuscitation
    Andreas Bohn
    Department of Anaesthesiology and Intensive Care Medicine, University Hospital Munster, Munster, Germany
    Curr Opin Anaesthesiol 21:200-3. 2008
    Current cardiopulmonary resuscitation guidelines emphasize that providing high-quality basic life support is the single most important contribution to successful resuscitation...
  88. ncbi How well are cardiopulmonary resuscitation and automated external defibrillator skills retained over time? Results from the Public Access Defibrillation (PAD) Trial
    Barbara Riegel
    School of Nursing, University of Pennsylvania, Philadelphia, PA 19104 6096, USA
    Acad Emerg Med 13:254-63. 2006
    The current standard for cardiopulmonary resuscitation (CPR) and automated external defibrillator (AED) retraining for laypersons is a four-hour course every two years...
  89. ncbi Major bleeding complications in cardiopulmonary resuscitation: the place of thrombolytic therapy in cardiac arrest due to massive pulmonary embolism
    Karin Janata
    Department of Emergency Medicine, Vienna General Hospital, Waehringer Guertel 18 20, 6D, A 1090, Vienna, Austria
    Resuscitation 57:49-55. 2003
    Thrombolytic therapy in patients with massive pulmonary embolism (MPE) and prolonged cardiopulmonary resuscitation (CPR) is subject to debate...
  90. ncbi Adverse hemodynamic effects of interrupting chest compressions for rescue breathing during cardiopulmonary resuscitation for ventricular fibrillation cardiac arrest
    R A Berg
    University of Arizona College of Medicine, Steele Memorial Children s Research Center, Department of Pediatrics, Sarver Heart Center, Tucson, Arizona, USA
    Circulation 104:2465-70. 2001
    Despite improving arterial oxygen saturation and pH, bystander cardiopulmonary resuscitation (CPR) with chest compressions plus rescue breathing (CC+RB) has not improved survival from ventricular fibrillation (VF) compared with chest ..
  91. ncbi The effect of a cellular-phone video demonstration to improve the quality of dispatcher-assisted chest compression-only cardiopulmonary resuscitation as compared with audio coaching
    Ji Sook Lee
    Department of Emergency Medicine, Ajou University School of Medicine, Suwon, Republic of Korea
    Resuscitation 82:64-8. 2011
    Bystander cardiopulmonary resuscitation (CPR) has shown to significantly improve the survival of cardiac-arrest victims...
  92. pmc Effect of the AutoPulse automated band chest compression device on hemodynamics in out-of-hospital cardiac arrest resuscitation
    Francois Xavier Duchateau
    Department of Anaesthesiology and Intensive Care, Beaujon University Hospital, 100 bd du Général Leclerc, 92110, Clichy, France
    Intensive Care Med 36:1256-60. 2010
    ..arrest (CA) emphasize continuous and effective chest compressions as one of the main factors of cardiopulmonary resuscitation (CPR) success...
  93. ncbi Pre-hospital cardiac arrest in Prague, Czech Republic--the Utstein-style report
    Ondrej Franek
    EMS Prague, Korunní 98, Prague 10, Czech Republic
    Resuscitation 81:831-5. 2010
    This study aimed to report results of pre-hospital cardiopulmonary resuscitation (CPR) in the city of Prague in accordance with 'Utstein-style' recommendations.
  94. ncbi Out-of-hospital airway management by paramedics and emergency physicians using laryngeal tubes
    Richard Schalk
    Clinic of Anaesthesiology, Intensive Care Medicine, and Pain Therapy, J W Goethe University Hospital Frankfurt, Theodor Stern Kai 7, D 60590 Frankfurt, Germany
    Resuscitation 81:323-6. 2010
    ..We prospectively evaluated the feasibility of laryngeal tubes used by paramedics and emergency physicians for out-of-hospital airway management...
  95. ncbi Instructor retraining and poster retraining are equally effective for the retention of BLS and AED skills of lifeguards
    Wiebe de Vries
    Department of Education and Development, Doczero, Uden, The Netherlands
    Eur J Emerg Med 17:150-7. 2010
    ..This cluster-randomized study compared two refresher training methods for basic life support and use of an automated external defibrillation: a traditional instructor-led course, and self-instruction by poster...
  96. ncbi The association between intra-arrest therapeutic hypothermia and return of spontaneous circulation among individuals experiencing out of hospital cardiac arrest
    John S Garrett
    Carolinas Medical Center, Department of Emergency Medicine, Charlotte, NC, USA
    Resuscitation 82:21-5. 2011
    ..Animal data suggest intra-arrest induction of therapeutic hypothermia (IATH) improves frequency of return of spontaneous circulation (ROSC). Our objective was to evaluate the association between IATH and ROSC...
  97. ncbi Changing incidence of out-of-hospital ventricular fibrillation, 1980-2000
    Leonard A Cobb
    Department of Medicine, University of Washington and Harborview Medical Center, 325 Ninth Ave, Seattle, WA 98104, USA
    JAMA 288:3008-13. 2002
    ..Recent reports from 2 European cities and an earlier observation from Seattle, Wash, suggest that the number of patients treated for out-of-hospital ventricular fibrillation (VF) has declined...
  98. pmc Postresuscitation care with mild therapeutic hypothermia and coronary intervention after out-of-hospital cardiopulmonary resuscitation: a prospective registry analysis
    Jan Thorsten Gräsner
    Department of Anaesthesiology and Intensive Care Medicine, University Hospital Schleswig Holstein, Campus Kiel, Schwanenweg 21, Kiel 24105, Germany
    Crit Care 15:R61. 2011
    Mild therapeutic hypothermia (MTH) has been shown to result in better neurological outcome after cardiopulmonary resuscitation. Percutaneous coronary intervention (PCI) may also be beneficial in patients after out-of-hospital cardiac ..
  99. ncbi Performance and skill retention of intubation by paramedics using seven different airway devices--a manikin study
    Kurt Ruetzler
    Department of Cardiothoracic and Vascular Anesthesia and Intensive Care Medicine, Medical University of Vienna, Austria
    Resuscitation 82:593-7. 2011
    ..This study investigates the usability of supraglottic airway devices compared to ETI and the skill retention of 41 previously inexperienced paramedics following training using a manikin model...
  100. ncbi Good outcome in every fourth resuscitation attempt is achievable--an Utstein template report from the Stavanger region
    Thomas Werner Lindner
    Department of Anaesthesiology and Intensive Care, Stavanger University Hospital, Norway
    Resuscitation 82:1508-13. 2011
    ..Out-of-hospital cardiac arrest (OHCA) is a major cause of death in the western world. We wanted to study changes in survival over time and factors linked to this in a region which have already reported high survival rates...
  101. ncbi Epidemiology and outcomes from non-traumatic out-of-hospital cardiac arrest in Korea: A nationwide observational study
    Ki ok Ahn
    Center for Education and Training of EMS and Rescue, Seoul Fire Academy, Seoul, Republic of Korea
    Resuscitation 81:974-81. 2010
    ..We aimed to describe the epidemiological features and to determine the predictors for survival to discharge of non-traumatic out-of-hospital cardiac arrest (OHCA) in Korea...

Research Grants64

  1. Development of a Pre-Hospital Ultra-Wide Band Radar Cardiac Function Monitor
    Gregory Walcott; Fiscal Year: 2007
    ..determination of the presence or absence of a carotid pulse by healthcare personnel when performing cardiopulmonary resuscitation, yet performance of pulse checks is time consuming and the results are often incorrect...
  2. SK2 Channels as Novel Neuroprotective Targets Against Cerebral Ischemia
    Paco S Herson; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Cardiac arrest/cardiopulmonary resuscitation (CA/CPR) causes ischemia, neuronal excitotoxicity and cognitive decline. Despite intensive efforts, outcome remains poor...
  3. CaMKII in global cerebral ischemia
    Paco S Herson; Fiscal Year: 2013
    ..applicant): Each year in the United States ~600,000 people suffer from cardiac arrest (CA) and receive cardiopulmonary resuscitation (CPR), resulting in hypoxia-ischemia (HI) of the brain and consequently in severe neurological ..
  4. Pyruvate: Powerful Brain Protection after Cardiac Arrest
    Robert T Mallet; Fiscal Year: 2013
    ..Moreover, intravenous pyruvate infusion during cardiopulmonary resuscitation (CPR) prevented subsequent neurological impairment and neuronal apoptosis 3 days after cardiac arrest...
  5. IMPACT OF HYDROGEN SULFIDE ON OUTCOME OF CARDIAC ARREST AND CARDIOPULMONARY RESUS
    Fumito Ichinose; Fiscal Year: 2013
    ..Despite advances in cardiopulmonary resuscitation (CPR) methods, 60-80% of these arrests result in immediate death, and of the remaining, only about 5 ..
  6. SIMLAB: Using Patient Simulation for Student Exploration of Community Health Issu
    PATRICIA LEAH WARD; Fiscal Year: 2013
    ..An Advisory Committee, consisting of experts from public health, academic medicine, education, technology, and industry, will guide the development and implementation of the Project. ..
  7. 12/15-Lipoxygenase and neurovascular damage following cardiac arrest
    Klaus van Leyen; Fiscal Year: 2013
    ..Severe ischemia and reperfusion injury is associated with cardiac arrest and subsequent cardiopulmonary resuscitation. Elucidating the role of 12/15-LOX in mediating ischemic damage may lead to novel therapeutic options ..
  8. Improving Outcomes in Cardiac Arrest/CPR with Inhaled Nitric Oxide
    Fumito Ichinose; Fiscal Year: 2013
    ..Despite advances in cardiopulmonary resuscitation (CPR) methods, 60-80% of these arrests result in immediate death, and of the remaining, only about 5 ..
  9. Hypothermia in Cardiac Arrest: Akt Preservation of Mitochondrial Integrity
    WILLARD WILLIAM SHARP; Fiscal Year: 2013
    ..Although promising, the effective and rapid implementation of TH during cardiopulmonary resuscitation (CPR) particularly in the out of hospital setting is technically challenging...
  10. Community-based End-of-life Intervention for African American Dementia Caregivers
    GLORIA J BONNER; Fiscal Year: 2013
    ..EduAct) intervention for AA family caregiver healthcare proxies (HCPs) to make EOL decisions on cardiopulmonary resuscitation (CPR), mechanical ventilation (MV), and tube feeding (TF)...
  11. Sex Difference in Renal Injury After Cardiac Arrest:Mechanisms of Estrogen Action
    Michael P Hutchens; Fiscal Year: 2013
    ..1 will determine whether glomerular endothelial and renal functional injury after cardiac arrest and cardiopulmonary resuscitation (CA/CPR) is sexually dimorphic and mediated by estrogen...
  12. Nanoparticle scavengers for in vivo sequestration of overdosed drug molecules
    Zhiguo Zhou; Fiscal Year: 2013
    ..S. in 2005 alone, and the number is growing rapidly. General rescue therapies such as cardiopulmonary resuscitation, intravenous catecholamines to support homeostasis are used to treat drug intoxications in emergency ..
  13. Reperfusion Injury Protection Strategies During Basic Life Support
    Demetri Yannopoulos; Fiscal Year: 2013
    ..More than 350,000 patients die or have severe neurological deficits each year despite best efforts in cardiopulmonary resuscitation (CPR)...
  14. Effect of Pulmonary Vasodilation on the Efficacy of Cardiopulmonary Resuscitation
    Gregory P Walcott; Fiscal Year: 2012
    ..We believe that manipulating the pulmonary vasculature will lead to a paradigm shift in resuscitation protocols and lead to an increased survival from cardiac arrest. ..
  15. Fibrillation and Defibrillation
    Peng Sheng Chen; Fiscal Year: 2010
    ..Spontaneous VF episodes are known to occur frequently during cardiopulmonary resuscitation and in patients with VF storms...
  16. Ventricular Fibrillation in a Globally Ischemic Heart: From Cell to ECG
    Alexey V Zaitsev; Fiscal Year: 2012
    ..It should also provide a scientific basis for the interpretation of VF ECG. This should help to optimize defibrillation and cardio-pulmonary resuscitation in the setting of out-of-hospital sudden cardiac arrest. ..
  17. Implementation of cardiopulmonary resuscitation training for at-risk families
    Benjamin S Abella; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Prompt delivery of cardiopulmonary resuscitation (CPR) increases survival from sudden cardiac arrest (SCA) by 2-3 fold, yet most bystander-witnessed victims still die without an initial CPR attempt...
  18. Sodium nitroprusside and mechanical CPR adjuncts for cardio-cerebral resuscitatio
    Demetri Yannopoulos; Fiscal Year: 2013
    ..patients suffer cardiac arrest each year in the United States, average survival rates following Cardiopulmonary Resuscitation (CPR) have averaged <5% for the last 5 decades...
  19. Cardiac Arrest: Improving CPR Quality and Survival
    Benjamin S Abella; Fiscal Year: 2010
    Cardiac arrest remains the number one killer in the developed world, despite the introduction of cardiopulmonary resuscitation (CPR) and defibrillation over 50 years ago. In the U.S...
  20. Extending Emergency Response Skills to Limited English Proficiency Communities
    Hendrika Meischke; Fiscal Year: 2011
    ....
  21. Pediatric Critical Care Research Network at Children's Hospital of Philadelphia
    Robert Allen Berg; Fiscal Year: 2013
    ..Many lives can be saved with effective cardiopulmonary resuscitation (CPR), yet CPR for children typically does not comply with life-saving CPR guidelines...
  22. Induced hypothermic arrest in traumatic shock
    Hasan Alam; Fiscal Year: 2005
    ..shock that leads to cardiovascular collapse does not respond well to conventional methods of cardiopulmonary resuscitation. Even when the source of bleeding can be controlled and circulation restored, cerebral ischemia ..
  23. Novel device for improving standard CPR outcomes
    Keith Lurie; Fiscal Year: 2007
    ..Phase 2 research is primarily intended to further develop a manual active compression decompression cardiopulmonary resuscitation (ACD CPR) device that can be easily used by lay and professional rescuers so that it can be ..
  24. CONTROL OF CEREBRAL REPERFUSION AFTER CARDIAC ARREST
    Peter Safar; Fiscal Year: 1990
    ..After cardiac arrest (CA) of more than 5 min and cardiopulmonary resuscitation (CPR), however, the "post- resuscitation syndrome" of multiple organ systems normally precludes ..
  25. CEREBRAL BLOOD FLOW AND METABOLISM DURING INFANT CPR
    Charles Schleien; Fiscal Year: 1990
    ..Pediatric Critical Care Medicine, during which he was instrumental in developing an infant pediatric cardiopulmonary resuscitation (CPR) model in piglets...
  26. EARLY ACCESS TO DEFIBRILLATION FOR VICTIMS OF OOH-CA
    Alfred Hallstrom; Fiscal Year: 2000
    ..involved training lay persons to recognize cardiac arrest, to access the 911 system, and to perform cardiopulmonary resuscitation. Existing methods of emergency resuscitation have inherent time delays for a trained responder with ..
  27. PORTABLE EXTRACORPOREAL RESUSCITATION CONSOLE
    Scott Merz; Fiscal Year: 1999
    ..its traditional function in cardiac surgery and hemodialysis, and now is being used for emergency cardiopulmonary resuscitation in the emergency room and cardiac catheterization laboratories, rapid warming for hypothermia victims, ..
  28. COGNITIVE RETRAINING IN SUDDEN CARDIAC ARREST SURVIVORS
    MARY SAUVE; Fiscal Year: 2000
    Despite advances in cardiopulmonary resuscitation (CPR) procedures, on average, fewer than 30 percent of the victims of sudden cardiac death in whom CPR is attempted live to hospital discharge...
  29. ADVANCE DIRECTIVE DISCUSSIONS WITH ELDERLY OUTPATIENTS
    PETER DITTO; Fiscal Year: 1993
    ..The AD discussion included the provision of scripted information about ADs, cardiopulmonary resuscitation (CPR), and artificial nutrition and hydration (ANH)...
  30. FIRST RESPONDER DEFIBRILLATION IN AN URBAN EMS SYSTEM
    Arthur Kellermann; Fiscal Year: 1990
    ..All will be trained to operate an AED and all will receive refresher training in cardiopulmonary resuscitation (CPR)...
  31. Pyruvate-enhanced cardiopulmonary resuscitation
    Robert Mallet; Fiscal Year: 2004
    ..efficacy of pyruvate to protect myocardium and cerebral cortex during cardiac arrest and closed chest cardiopulmonary resuscitation (CPR)...
  32. High Efficiency Hypo/Hyperthermia System
    William Ohley; Fiscal Year: 2003
    ..Furthermore, they are not well suited to being used during administration of cardiopulmonary resuscitation (CPR)...
  33. Treatment strategies in a rat model of cardiac arrest
    Joseph LaManna; Fiscal Year: 2005
    A significant number of individuals die soon after a successful cardiopulmonary resuscitation form cardiac arrest, and of those that survive a significant fraction have residual neurological deficit...
  34. Brain Injury During CPR Prevented by Vascular Nitroxide
    CARLETON HSIA; Fiscal Year: 2003
    ..Fewer than 10% of cardiopulmonary resuscitation (CPR) attempts result in survival without brain damage when treatment occurs in pre-hospital or a non-..
  35. IN VIVO EPR IMAGING OF FREE RADICALS AT 300 MHZ
    Jay Zweier; Fiscal Year: 2001
    ....
  36. BLACK CAREGIVERS OF OLDER ADULTS: TRUST AND HEALTH CARE
    Gloria Bonner; Fiscal Year: 2002
    ..and personal characteristics of African- American family caregivers on health care decisions regarding cardiopulmonary resuscitation (CPR), mechanical ventilation (MV), tube feeding (TF), and intravenous hydration (IV) for elderly ..
  37. TCD Post-Resuscitation Blood Flow & Edema Monitor
    MARK MOEHRING; Fiscal Year: 2006
    The aim of this project is to contribute a tool towards accomplishing improved outcomes following cardiopulmonary resuscitation (CPR). It is submitted in response to NIH program announcement PA-04-059...
  38. Unit-dose Intraosseous Auto-injector for Resuscitation
    Larry Miller; Fiscal Year: 2004
    ..a chain of survival, which includes 1) early access to the emergency medical system (EMS), 2) early cardiopulmonary resuscitation, and 3) early advanced cardiac care, including the administration of resuscitative cardiac drugs...
  39. Pulse Doppler Ultrasound Imaging System
    JOAN CARROLL; Fiscal Year: 2004
    ..therapy on myocardial contractile performance and cerebral perfusion following cardiac arrest and cardiopulmonary resuscitation (v) skeletal muscle vascular conductance and cardiac output to assist in assessing arterial baroreflex ..
  40. Effects of social factors on cardiac arrest outcome
    ANNE DEVRIES; Fiscal Year: 2009
    ..to social stress on the histological, physiological and behavioral consequences of cardiac arrest and cardiopulmonary resuscitation (CPR)...
  41. Home Automatic external Defibrillator Training
    Thomas Rea; Fiscal Year: 2007
    ..Alternatively, if nominal video-based approaches achieve comparable outcomes, training efforts can be streamlined at considerable cost savings with fewer impediments for distribution and dissemination. [unreadable] [unreadable]..
  42. Ischemic Arrest, Cytokines, and Organ Dysfunction
    James Niemann; Fiscal Year: 2008
    ..In aim 3, the effect of anti-TNF therapy on long-term survival and neurologic outcome will be evaluated. [unreadable] [unreadable]..
  43. OPTIMAL PREHOSPITAL CARE OF CHILDHOOD CARDIAC ARREST
    Ian Stiell; Fiscal Year: 2004
    ..The PIs propose to conduct a large feasibility review in five urban areas and to conduct four study planning workshops. ..
  44. Transducer for indirect blood pressure& O2 saturation
    Leslie Geddes; Fiscal Year: 2005
    ..The neonatologist, the premature infant physician and the small-infant pediatrician have no single instrument that provides all of these vital signs. ..
  45. Hypothermia and Gene Expression After Cardiac Arrest
    Clifton Callaway; Fiscal Year: 2005
    ..These pathways will be blocked and stimulated during hypothermic reperfusion, and behavioral and histological outcome for cardiac arrest will be measured. ..
  46. New Technologies in Electrophysiology Intervention
    Henry Halperin; Fiscal Year: 2005
    ..His work has been primarily in the fields of cardiopulmonary resuscitation and electrophysiology, where he continues to apply scientifically-based technology development to ..
  47. HIGH RESOLUTION MRI OF MYOCARDIAL DEFORMATION
    Henry Halperin; Fiscal Year: 2001
    ....
  48. MAGNETIC RESONANCE GUIDED ELECTROPHYSIOLOGY INTERVENTION
    Henry Halperin; Fiscal Year: 2008
    ..Irvine Biomedical is supplying non-magnetic electrode catheters for use in the MRI scanner. ..
  49. Impact of sleepiness on heart failure self-care
    Barbara Riegel; Fiscal Year: 2009
    ..This study is expected to expand existing knowledge and clarify our understanding of the mechanisms linking EDS, failed self-care, poor HRQL, and unplanned hospitalizations in persons with heart failure. ..
  50. BRAIN ISCHEMIA AND MAP KINASE ACTIVATION
    Clifton Callaway; Fiscal Year: 2003
    ..The conduct of this project will provide extensive opportunities for collaboration with other basic scientists at the University of Pittsburgh, and promote the candidate's growth as an independent researcher. ..
  51. Red Blood Cells, Nitric Oxide and Pulmonary Circulation
    Steven Deem; Fiscal Year: 2008
    ..abstract_text> ..
  52. Calpain mediated injury in post ischemic neurons
    ROBERT NEUMAR; Fiscal Year: 2008
    ..The results will provide fundamental insights into the mechanism of delayed post-ischemic neuronal necrosis, and facilitate the development of effective therapies for patients suffering from cardiac arrest and stroke. ..
  53. PSYCHOSOCIAL FACTORS IN SUDDEN CARDIAC DEATH
    Sue Thomas; Fiscal Year: 2002
    ..The combination of data from PFOS and SCD-HeFT will provide a holistic assessment of HF patients. ..
  54. IMMUNOPROBES FOR LUBRICIN FROM HUMAN SYNOVIAL FLUID
    Gregory Jay; Fiscal Year: 2003
    ..This principal goal of this investigation is to develop new immunological probes and with these identify the concentration of lubricin in synovial fluid extracted from healthy and arthritic human joints. ..
  55. CARDIOVASCULAR RESEARCH TRAINING
    Douglas Zipes; Fiscal Year: 2003
    ..In addition, the program is ideally suited to effectively recruit under-represented minorities. We proposed to train 3 postdoctoral Fellows each year for 2 years as part of this grant. ..
  56. SERVICE OUTREACH TO HOMELESS DRUG USERS
    Stephen Magura; Fiscal Year: 2003
    ..3) To determine the client characteristics and service process variables which predict entry to and retention in treatment/interventions for drug addiction, as well as other differences in outcomes. ..
  57. An Implantable Wireless Myoelectric Sensor for Prosthetic Control
    Patrick Lichter; Fiscal Year: 2006
    ..The proposed implanted technology will allow prosthetic limb manufacturers to provide products with increased performance, capability, and patient-comfort. [unreadable] [unreadable] [unreadable]..
  58. Post-Countershock CPR After Prolonged VF
    Robert Berg; Fiscal Year: 2005
    ..The results of this study should translate into a more successful new therapeutic strategy to restore heart function and preserve neurological function after prolonged VF. ..
  59. Oral Care and Respiratory Pathogen Colonization
    Ozan Akca; Fiscal Year: 2004
    ..Reducing respiratory pathogen colonization in the mouth could significantly reduce the morbidity and cost of VAP. ..