resuscitation

Summary

Summary: The restoration to life or consciousness of one apparently dead. (Dorland, 27th ed)

Top Publications

  1. ncbi Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008
    R Phillip Dellinger
    Cooper University Hospital, Camden, NJ, USA
    Crit Care Med 36:296-327. 2008
  2. doi Mortality after fluid bolus in African children with severe infection
    Kathryn Maitland
    Kilifi Clinical Trials Facility, Kenya Medical Research Institute KEMRI Wellcome Trust Research Programme, Kilifi, Kenya
    N Engl J Med 364:2483-95. 2011
  3. doi Hydroxyethyl starch or saline for fluid resuscitation in intensive care
    John A Myburgh
    Division of Critical Care and Trauma, George Institute For Global Health, Sydney, NSW, Australia
    N Engl J Med 367:1901-11. 2012
  4. pmc Association between timing of antibiotic administration and mortality from septic shock in patients treated with a quantitative resuscitation protocol
    Michael A Puskarich
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC, USA
    Crit Care Med 39:2066-71. 2011
  5. pmc Neonatal resuscitation and immediate newborn assessment and stimulation for the prevention of neonatal deaths: a systematic review, meta-analysis and Delphi estimation of mortality effect
    Anne C C Lee
    Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    BMC Public Health 11:S12. 2011
  6. ncbi Early reversal of pediatric-neonatal septic shock by community physicians is associated with improved outcome
    Yong Y Han
    Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Pediatrics 112:793-9. 2003
  7. ncbi Damage control resuscitation: directly addressing the early coagulopathy of trauma
    John B Holcomb
    USAISR, Fort Sam Houston, TX 78234 6315, USA
    J Trauma 62:307-10. 2007
  8. doi Airway obstruction during mask ventilation of very low birth weight infants during neonatal resuscitation
    Neil N Finer
    UCSD Medical Center, 402 W Dickenson St 8774, San Diego, CA 92103 8774, USA
    Pediatrics 123:865-9. 2009
  9. pmc Exploring mechanisms of excess mortality with early fluid resuscitation: insights from the FEAST trial
    Kathryn Maitland
    Wellcome Trust Centre for Clinical Tropical Medicine, Department of Paediatrics, Faculty of Medicine, St Marys Campus, Norfolk Place, Imperial College, London W2 1PG, UK
    BMC Med 11:68. 2013
  10. doi The role of albumin as a resuscitation fluid for patients with sepsis: a systematic review and meta-analysis
    Anthony P Delaney
    Northern Clinical School, Sydney Medical School, University of Sydney, Sydney, Australia
    Crit Care Med 39:386-91. 2011

Detail Information

Publications406 found, 100 shown here

  1. ncbi Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008
    R Phillip Dellinger
    Cooper University Hospital, Camden, NJ, USA
    Crit Care Med 36:296-327. 2008
    ..To provide an update to the original Surviving Sepsis Campaign clinical management guidelines, "Surviving Sepsis Campaign Guidelines for Management of Severe Sepsis and Septic Shock," published in 2004...
  2. doi Mortality after fluid bolus in African children with severe infection
    Kathryn Maitland
    Kilifi Clinical Trials Facility, Kenya Medical Research Institute KEMRI Wellcome Trust Research Programme, Kilifi, Kenya
    N Engl J Med 364:2483-95. 2011
    The role of fluid resuscitation in the treatment of children with shock and life-threatening infections who live in resource-limited settings is not established.
  3. doi Hydroxyethyl starch or saline for fluid resuscitation in intensive care
    John A Myburgh
    Division of Critical Care and Trauma, George Institute For Global Health, Sydney, NSW, Australia
    N Engl J Med 367:1901-11. 2012
    The safety and efficacy of hydroxyethyl starch (HES) for fluid resuscitation have not been fully evaluated, and adverse effects of HES on survival and renal function have been reported.
  4. pmc Association between timing of antibiotic administration and mortality from septic shock in patients treated with a quantitative resuscitation protocol
    Michael A Puskarich
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC, USA
    Crit Care Med 39:2066-71. 2011
    We sought to determine the association between time to initial antibiotics and mortality of patients with septic shock treated with an emergency department-based early resuscitation protocol.
  5. pmc Neonatal resuscitation and immediate newborn assessment and stimulation for the prevention of neonatal deaths: a systematic review, meta-analysis and Delphi estimation of mortality effect
    Anne C C Lee
    Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    BMC Public Health 11:S12. 2011
    ..03 million from complications of prematurity. No systematic assessment of mortality reduction from tactile stimulation or resuscitation has been published.
  6. ncbi Early reversal of pediatric-neonatal septic shock by community physicians is associated with improved outcome
    Yong Y Han
    Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Pediatrics 112:793-9. 2003
    Experimental and clinical studies of septic shock support the concept that early resuscitation with fluid and inotropic therapies improves survival in a time-dependent manner...
  7. ncbi Damage control resuscitation: directly addressing the early coagulopathy of trauma
    John B Holcomb
    USAISR, Fort Sam Houston, TX 78234 6315, USA
    J Trauma 62:307-10. 2007
  8. doi Airway obstruction during mask ventilation of very low birth weight infants during neonatal resuscitation
    Neil N Finer
    UCSD Medical Center, 402 W Dickenson St 8774, San Diego, CA 92103 8774, USA
    Pediatrics 123:865-9. 2009
    ..of adequate but not excessive ventilation remains one of the most common problems encountered during neonatal resuscitation, especially in the very low birth weight infant...
  9. pmc Exploring mechanisms of excess mortality with early fluid resuscitation: insights from the FEAST trial
    Kathryn Maitland
    Wellcome Trust Centre for Clinical Tropical Medicine, Department of Paediatrics, Faculty of Medicine, St Marys Campus, Norfolk Place, Imperial College, London W2 1PG, UK
    BMC Med 11:68. 2013
    Early rapid fluid resuscitation (boluses) in African children with severe febrile illnesses increases the 48-hour mortality by 3.3% compared with controls (no bolus)...
  10. doi The role of albumin as a resuscitation fluid for patients with sepsis: a systematic review and meta-analysis
    Anthony P Delaney
    Northern Clinical School, Sydney Medical School, University of Sydney, Sydney, Australia
    Crit Care Med 39:386-91. 2011
    To assess whether resuscitation with albumin-containing solutions, compared with other fluids, is associated with lower mortality in patients with sepsis.
  11. pmc Initiation of resuscitation with high tidal volumes causes cerebral hemodynamic disturbance, brain inflammation and injury in preterm lambs
    Graeme R Polglase
    The Ritchie Centre, Monash Institute of Medical Research, Monash University, Clayton, Victoria, Australia
    PLoS ONE 7:e39535. 2012
    ..The aim of this study was to compare an initial 15 min of high V(T) resuscitation strategy to a less injurious resuscitation strategy on cerebral haemodynamics, inflammation and injury.
  12. ncbi Comparison of three fluid solutions for resuscitation in dengue shock syndrome
    Bridget A Wills
    Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
    N Engl J Med 353:877-89. 2005
    ..Although volume replacement is recognized as the critical therapeutic intervention, World Health Organization management guidelines remain empirical rather than evidence-based...
  13. doi Effect of sustained inflation duration; resuscitation of near-term asphyxiated lambs
    Claus Klingenberg
    Department of Paediatrics, University Hospital of North Norway, N 9038 Tromsø, Norway
    Arch Dis Child Fetal Neonatal Ed 98:F222-7. 2013
    The 2010 ILCOR neonatal resuscitation guidelines do not specify appropriate inflation times for the initial lung inflations in apnoeic newborn infants...
  14. ncbi Damage control resuscitation: from emergency department to the operating room
    Juan C Duchesne
    Section of Trauma and Critical Care Surgery, Department of Surgery and Anesthesia, Tulane University School of Medicine, New Orleans, Louisiana 70112 2699, USA
    Am Surg 77:201-6. 2011
    ..Traditional management centered upon correction of acidosis and hypotension with crystalloids. Damage control resuscitation (DCR) is permissive hypotension and early hemostatic resuscitation combined identified and corrects ..
  15. pmc Neonatal resuscitation in low-resource settings: what, who, and how to overcome challenges to scale up?
    Stephen N Wall
    Saving Newborn Lives Save the Children USA, Washington DC and Cape Town, South Africa
    Int J Gynaecol Obstet 107:S47-62, S63-4. 2009
    ..10 million babies do not breathe immediately at birth, of which about 6 million require basic neonatal resuscitation. The major burden is in low-income settings, where health system capacity to provide neonatal resuscitation is ..
  16. doi Damage control resuscitation in combination with damage control laparotomy: a survival advantage
    Juan C Duchesne
    Section of Trauma and Critical Care Surgery, Department of Surgery, Emergency Medicine and Anesthesia, Tulane University Health Science Center, New Orleans, Louisiana 70112 2699, USA
    J Trauma 69:46-52. 2010
    ..Correction of coagulopathy with close ratio resuscitation while limiting crystalloid forms a new methodology known as damage control resuscitation (DCR)...
  17. doi Massive transfusion protocols: the role of aggressive resuscitation versus product ratio in mortality reduction
    Daniel J Riskin
    Department of Surgery, Stanford School of Medicine, Stanford, CA, USA
    J Am Coll Surg 209:198-205. 2009
    ..Our purpose was to evaluate mortality and blood product use in the context of a newly initiated massive transfusion protocol (MTP)...
  18. ncbi Aggressive management of dengue shock syndrome may decrease mortality rate: a suggested protocol
    Suchitra Ranjit
    Pediatric Intensive Care Unit, Apollo Hospitals, Chennai, India
    Pediatr Crit Care Med 6:412-9. 2005
    ....
  19. doi Fluid resuscitation in septic shock: a positive fluid balance and elevated central venous pressure are associated with increased mortality
    John H Boyd
    University of British Columbia Critical Care Research Laboratories, Heart Lung Institute, St Paul s Hospital, Vancouver, British Columbia, Canada
    Crit Care Med 39:259-65. 2011
    To determine whether central venous pressure and fluid balance after resuscitation for septic shock are associated with mortality.
  20. pmc Resuscitation fluid use in critically ill adults: an international cross-sectional study in 391 intensive care units
    Simon Finfer
    Critical Care and Trauma Division, The George Institute for International Health, PO Box M201, Missenden Road, NSW 2050, Australia
    Crit Care 14:R185. 2010
    Recent evidence suggests that choice of fluid used for resuscitation may influence mortality in critically ill patients.
  21. doi A systematic review of third-generation hydroxyethyl starch (HES 130/0.4) in resuscitation: safety not adequately addressed
    Christiane S Hartog
    Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Friedrich Schiller University, Erlanger Allee 101, D 07747 Jena, Germany
    Anesth Analg 112:635-45. 2011
    ..Our goal was to assess whether published studies on HES 130/0.4 resuscitation are sufficiently well designed to draw conclusions about the safety of this compound...
  22. doi American Burn Association practice guidelines burn shock resuscitation
    Tam N Pham
    University of Washington Burn Center, Seattle, Washington 98104, USA
    J Burn Care Res 29:257-66. 2008
  23. pmc Modulation of syndecan-1 shedding after hemorrhagic shock and resuscitation
    Ricky J Haywood-Watson
    Department of Surgery, The University of Texas Health Science Center at Houston, Houston, Texas, United States of America
    PLoS ONE 6:e23530. 2011
    ..demonstrated significantly elevated levels of syndecan-1 (554±93 ng/ml) after injury, which decreased with resuscitation (187±36 ng/ml) but was elevated compared to normal donors (27±1 ng/ml)...
  24. ncbi Treatment of uncontrolled hemorrhagic shock after liver trauma: fatal effects of fluid resuscitation versus improved outcome after vasopressin
    Claus Raedler
    Department of Anesthesiology and Critical Care Medicine, Leopold Franzens University, Anichstrasse 35, 6020 Innsbruck, Austria
    Anesth Analg 98:1759-66, table of contents. 2004
    ..shock, we evaluated the effects of vasopressin versus an equal volume of saline placebo versus fluid resuscitation on hemodynamic variables and short-term survival...
  25. doi Saline versus Plasma-Lyte A in initial resuscitation of trauma patients: a randomized trial
    Jason B Young
    From the Department of Surgery, University of California, Davis Medical Center, Sacramento, CA
    Ann Surg 259:255-62. 2014
    We sought to compare resuscitation with 0.9% NaCl versus Plasma-Lyte A, a calcium-free balanced crystalloid solution, hypothesizing that Plasma-Lyte A would better correct the base deficit 24 hours after injury.
  26. doi Arginine vasopressin: the future of pressure-support resuscitation in hemorrhagic shock
    Tanya Anand
    Department of Surgery, Division of Trauma and Surgical Critical Care, Kern Medical Center, Bakersfield, CA 93306, USA
    J Surg Res 178:321-9. 2012
    ..During the past 2 decades, animal studies, case reports, and reviews have documented the minimized blood loss and improved perfusion pressures in those receiving pressure support with AVP...
  27. doi Preterm resuscitation I: clinical approaches to improve management in delivery room
    Mario Rudiger
    Department for Neonatology and Pediatric Intensive Care, Children s Clinic of the University Hospital Carl Gustav Carus, Fetscherstrasse 74, Dresden, Germany
    Early Hum Dev 87:749-53. 2011
    ..However, a new conceptual framework that focuses on an individualised 'support of transition' rather than on 'resuscitation' is necessary. Video-recordings of DR-management represent a valuable tool to improve care...
  28. doi Effects of acute ethanol gavage on intestinal integrity after hemorrhage/resuscitation
    Borna Relja
    Department of Trauma, Hand and Reconstructive Surgery, Johann Wolfgang Goethe University Frankfurt am Main, Frankfurt, Germany
    Scand J Gastroenterol 48:448-58. 2013
    In hemorrhagic shock with subsequent resuscitation (H/R), increased pro-inflammatory changes contribute to tissue injury and mortality in rodent models...
  29. doi Effects of intravenous sulfide during resuscitated porcine hemorrhagic shock*
    Hendrik Bracht
    Sektion Anasthesiologische Pathophysiologie und Verfahrensentwicklung, Universitatsklinikum, Ulm, Germany
    Crit Care Med 40:2157-67. 2012
    ..sulfide administration in rodents may not be applicable to larger species, we tested the hypothesis whether intravenous Na2S (sulfide) would beneficially influence organ dysfunction during long-term, porcine hemorrhage and resuscitation.
  30. doi Respiratory monitoring of neonatal resuscitation
    Georg M Schmölzer
    Department of Newborn Research, Royal Women s Hospital, Neonatal Services, Victoria 3052, Australia
    Arch Dis Child Fetal Neonatal Ed 95:F295-303. 2010
    ..Examples demonstrating its potential usefulness during resuscitations are provided. However, further studies are needed to investigate whether it can help improve short-term and long-term outcomes...
  31. doi An experimental model of neonatal normocapnic hypoxia and resuscitation in Landrace/Large White piglets
    Filippia Aroni
    National and Kapodistrian University of Athens, Medical School, Athens, Greece
    J Matern Fetal Neonatal Med 25:1750-4. 2012
    The aim of this study is to describe and evaluate an experimental model of neonatal normocapnic hypoxia and resuscitation.
  32. doi Fluid resuscitation with 6% hydroxyethyl starch (130/0.4) in acutely ill patients: an updated systematic review and meta-analysis
    David J Gattas
    Critical Care and Trauma Division, The George Institute for Global Health, University of Sydney, Australia
    Anesth Analg 114:159-69. 2012
    Recent research suggests that 6% hydroxyethyl starch (HES) 130/0.4 is one of the most frequently used resuscitation fluids worldwide...
  33. doi Resuscitation with hydroxyethyl starch improves renal function and lactate clearance in penetrating trauma in a randomized controlled study: the FIRST trial (Fluids in Resuscitation of Severe Trauma)
    M F M James
    Department of Anaesthesia, Groote Schuur Hospital and Faculty of Health Sciences, University of Cape Town, Observatory, Cape Town, Western Cape 7925, South Africa
    Br J Anaesth 107:693-702. 2011
    The role of fluids in trauma resuscitation is controversial. We compared resuscitation with 0.9% saline vs hydroxyethyl starch, HES 130/0...
  34. doi Colloids versus crystalloids for fluid resuscitation in critically ill patients
    Pablo Perel
    Cochrane Injuries Group, London School of Hygiene and Tropical Medicine, London, UK
    Cochrane Database Syst Rev 6:CD000567. 2012
    Colloid solutions are widely used in fluid resuscitation of critically ill patients. There are several choices of colloid and there is ongoing debate about the relative effectiveness of colloids compared to crystalloid fluids.
  35. doi Fluid resuscitation with 6 % hydroxyethyl starch (130/0.4 and 130/0.42) in acutely ill patients: systematic review of effects on mortality and treatment with renal replacement therapy
    David J Gattas
    The George Institute for Global Health, Sydney, Australia
    Intensive Care Med 39:558-68. 2013
    To determine whether fluid resuscitation of acutely ill adults with 6 % hydroxyethyl starch (6 % HES 130) with a molecular weight of 130 kD and a molar substitution ratio of approximately 0...
  36. doi Providing PEEP during neonatal resuscitation: which device is best?
    Jennifer A Dawson
    Neonatal Services, The Royal Women s Hospital, Melbourne, Australia
    J Paediatr Child Health 47:698-703. 2011
    The study aims to compare three commonly used neonatal resuscitation devices, the Laerdal self-inflating bag with a positive end expiratory pressure (PEEP) valve, a T-piece resuscitator (T-piece) and a flow-inflating bag to provide peak ..
  37. ncbi Paracentesis for resuscitation-induced abdominal compartment syndrome: an alternative to decompressive laparotomy in the burn patient
    Michael W Parra
    Department of Surgical Education, Orlando Regional Medical Center, Orlando, Florida 32806, USA
    J Trauma 60:1119-21. 2006
  38. doi Newborn care training of midwives and neonatal and perinatal mortality rates in a developing country
    Waldemar A Carlo
    Division of Neonatology, Department of Pediatrics, School of Medicine, University of Alabama at Birmingham, 9380 Women and Infants Center, 1700 6th Ave South Birmingham, AL 35233, USA
    Pediatrics 126:e1064-71. 2010
    ..This study was designed to test the hypothesis that 2 training programs would reduce incrementally 7-day neonatal mortality rates for low-risk institutional deliveries...
  39. pmc Critical care management of severe traumatic brain injury in adults
    Samir H Haddad
    Intensive Care Department, King Abdulaziz Medical City, Riyadh, Kingdom of Saudi Arabia
    Scand J Trauma Resusc Emerg Med 20:12. 2012
    ..In this review, the critical care management of severe TBI will be discussed with focus on monitoring, avoidance and minimization of secondary brain insults, and optimization of cerebral oxygenation and CPP...
  40. ncbi Lipopolysaccharide-binding protein modulates hepatic damage and the inflammatory response after hemorrhagic shock and resuscitation
    Mark Lehnert
    Medical Univ of South Carolina, 280 Calhoun St, PO Box 250140, Charleston, SC 29425, USA
    Am J Physiol Gastrointest Liver Physiol 291:G456-63. 2006
    Hemorrhagic shock and resuscitation cause endotoxemia and hepatocellular damage...
  41. doi Hemodynamic and perfusion end points for volemic resuscitation in sepsis
    Fernando José da Silva Ramos
    Intensive Care and Anesthesiology Research Laboratory, Research and Education Institute, Hospital Sirio Libanes, University of Sao Paulo School of Medicine, Sao Paulo, Brazil
    Shock 34:34-9. 2010
    ..commonly used hemodynamic and perfusion parameters for hemodynamic optimization in sepsis, emphasizing the physiological background for their use and the studies that demonstrated their effectiveness as goals of volemic resuscitation.
  42. pmc Weight estimation in resuscitation: is the current formula still valid?
    Mark Luscombe
    The Royal Hallamshire Hospital, Sheffield, South Yorkshire, UK
    Arch Dis Child 92:412-5. 2007
    ..If a significant difference was found, the data would be used to derive a more accurate formula...
  43. doi A peptide inhibitor of C-jun N-terminal kinase modulates hepatic damage and the inflammatory response after hemorrhagic shock and resuscitation
    Mark Lehnert
    Department of Trauma Surgery, JW Goethe University, Frankfurt, Germany
    Shock 30:159-65. 2008
    Hemorrhage and resuscitation (H/R) leads to phosphorylation of mitogen-activated stress kinases, an event that is associated with organ damage...
  44. doi Controversy in trauma resuscitation: do ratios of plasma to red blood cells matter?
    Lynn G Stansbury
    R Adams Cowley Shock Trauma Center, University of Maryland School of Medicine, Baltimore, USA
    Transfus Med Rev 23:255-65. 2009
    ..RBC) was accompanied by plasma replacement at 1:1 proportions, interest in the plasma-to-RBC ratio during resuscitation in both the trauma and transfusion communities has been intense...
  45. doi Comparison of 6% hydroxyethyl starch 130/0.4 and saline solution for resuscitation of the microcirculation during the early goal-directed therapy of septic patients
    Arnaldo Dubin
    Servicio de Terapia Intensiva, Sanatorio Otamendi y Miroli, Azcuenaga 870, Buenos Aires C1115AAB, Argentina
    J Crit Care 25:659.e1-8. 2010
    The aim of this study was to show that 6% hydroxyethyl starch (HES) 130/0.4 achieves a better resuscitation of the microcirculation than normal saline solution (SS), during early goal-directed therapy (EGDT) in septic patients.
  46. pmc Resuscitation and transfusion principles for traumatic hemorrhagic shock
    Philip C Spinella
    University of Connecticut, Pediatric Intensivist, Department of Pediatrics, Department of Surgery, Connecticut Children s Medical Center, Hartford, CT 06106, USA
    Blood Rev 23:231-40. 2009
    ..We also describe the concept of damage control resuscitation (DCR), an early and aggressive prevention and treatment of hemorrhagic shock for patients with severe life-..
  47. ncbi Fluid resuscitation preserves cardiac output but cannot prevent organ damage in a porcine model during 24 h of intraabdominal hypertension
    Alexander Schachtrupp
    Department of Surgery, Technical University of Aachen, Aachen, Germany
    Shock 24:153-8. 2005
    ..The purpose of this study was to evaluate whether fluid resuscitation can preserve organ integrity together with CO. We examined 12 domestic pigs with a mean body weight of 48 kg...
  48. ncbi In-hospital cardiopulmonary resuscitation: patient, arrest and resuscitation factors associated with survival
    A J Tortolani
    Department of Surgery, North Shore University Hospital, Manhasset, NY 11030
    Resuscitation 20:115-28. 1990
    ..One hundred fifty-three (33%) patients were alive 24 h after initiation of cardiopulmonary resuscitation; 69 (45% of 24-h survivors, 15% of all patients) were discharged alive...
  49. pmc Effect of training traditional birth attendants on neonatal mortality (Lufwanyama Neonatal Survival Project): randomised controlled study
    Christopher J Gill
    Center for Global Health and Development, Boston University, Boston, MA, USA
    BMJ 342:d346. 2011
    ..To determine whether training traditional birth attendants to manage several common perinatal conditions could reduce neonatal mortality in the setting of a resource poor country with limited access to healthcare...
  50. doi Time- and fluid-sensitive resuscitation for hemodynamic support of children in septic shock: barriers to the implementation of the American College of Critical Care Medicine/Pediatric Advanced Life Support Guidelines in a pediatric intensive care unit in
    Cláudio F Oliveira
    Department of Pediatrics, Faculdade de Medicina, Pediatric Intensive Care Unit, Instituto da Criança Pedro de Alcântra, Universidade de Sao Paulo, Sao Paulo, Brazil
    Pediatr Emerg Care 24:810-5. 2008
    To analyze mortality rates of children with severe sepsis and septic shock in relation to time-sensitive fluid resuscitation and treatments received and to define barriers to the implementation of the American College of Critical Care ..
  51. doi Fluid resuscitation does not improve renal oxygenation during hemorrhagic shock in rats
    Matthieu Legrand
    Department of Translational Physiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Anesthesiology 112:119-27. 2010
    The resuscitation strategy for hemorrhagic shock remains controversial, with the kidney being especially prone to hypoxia.
  52. ncbi The cellular, metabolic, and systemic consequences of aggressive fluid resuscitation strategies
    Bryan A Cotton
    Department of General Surgery, Vanderbilt University School of Medicine, Nashville, TN 37212, USA
    Shock 26:115-21. 2006
    Increasing evidence has demonstrated that aggressive crystalloid-based resuscitation strategies are associated with cardiac and pulmonary complications, gastrointestinal dysmotility, coagulation disturbances, and immunological and ..
  53. ncbi Successful resuscitation of a patient with ropivacaine-induced asystole after axillary plexus block using lipid infusion
    R J Litz
    Department of Anaesthesiology and Intensive Care Medicine, Fetscher Str 74, University Hospital Dresden, 01307 Dresden, Germany
    Anaesthesia 61:800-1. 2006
    ..After 10 min of unsuccessful cardiopulmonary resuscitation, a bolus of 100 ml of Intralipid 20% (2 ml.kg(-1)) was administered followed by a continuous infusion of 10 ml...
  54. pmc Brief, large tidal volume ventilation initiates lung injury and a systemic response in fetal sheep
    Noah H Hillman
    Cincinnati Children s Hospital Medical Center, Division of Pulmonary Biology, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Am J Respir Crit Care Med 176:575-81. 2007
    ..Premature infants are exposed to potentially injurious ventilation in the delivery room. Assessments of lung injury are confounded by effects of subsequent ventilatory support...
  55. pmc Anti-HMGB1 neutralizing antibody ameliorates gut barrier dysfunction and improves survival after hemorrhagic shock
    Runkuan Yang
    Department of Critical Care Medicine, University of Pittsburgh School of Medicine, PA 15621, USA
    Mol Med 12:105-14. 2006
    Intestinal barrier dysfunction occurs following hemorrhagic shock and resuscitation (HS/R). High-mobility group B1 (HMGB1) has been shown to increase the permeability of Caco-2 human enterocyte-like epithelial monolayers in vitro...
  56. pmc Occult hypoperfusion is associated with increased mortality in hemodynamically stable, high-risk, surgical patients
    André Meregalli
    Central Intensive Care Unit of the Santa Casa Hospital, Porto Alegre, Brazil
    Crit Care 8:R60-5. 2004
    ..Our aim was to examine whether serial blood lactate levels could be used as predictors of outcome...
  57. doi Resuscitation with hypertonic saline-dextran reduces serum biomarker levels and correlates with outcome in severe traumatic brain injury patients
    Andrew J Baker
    Brain Injury Laboratory, Cara Phelan Centre for Trauma Research, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    J Neurotrauma 26:1227-40. 2009
    ..prognostic indicators of outcome after TBI, but they have not previously been studied in the context of fluid resuscitation. This randomized controlled trial compared serum concentrations of S100B, NSE, and MBP in adult severe TBI ..
  58. ncbi IL-6 is essential for development of gut barrier dysfunction after hemorrhagic shock and resuscitation in mice
    Runkuan Yang
    Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, USA
    Am J Physiol Gastrointest Liver Physiol 285:G621-9. 2003
    ..role of IL-6 as a mediator of the alterations in gut barrier function that occur after hemorrhagic shock and resuscitation (HS/R)...
  59. ncbi A profile of combat injury
    Howard R Champion
    Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA
    J Trauma 54:S13-9. 2003
    ..injury) in both the civilian and military arenas, combat trauma has unique considerations with regard to acute resuscitation, including (1) the high energy and high lethality of wounding agents; (2) multiple causes of wounding; (3) ..
  60. doi Fluid resuscitation: past, present, and the future
    Heena P Santry
    Department of Surgery, Division of Trauma, Emergency Surgery, and Surgical Critical Care, Massachusetts General Hospital Harvard Medical School, Boston, MA 02114, USA
    Shock 33:229-41. 2010
    Hemorrhage remains a major cause of preventable death following both civilian and military trauma. The goals of resuscitation in the face of hemorrhagic shock are restoring end-organ perfusion and maintaining tissue oxygenation while ..
  61. pmc Alpha7 cholinergic-agonist prevents systemic inflammation and improves survival during resuscitation
    Bolin Cai
    Laboratory of Anti inflammatory Signaling and Surgical Immunology, UMDNJ New Jersey Medical School, Newark, NJ 07103, USA
    J Cell Mol Med 13:3774-85. 2009
    Severe haemorrhage is a common cause of death despite the recent advances in critical care. Conventional resuscitation fluids are designed to re-establish tissue perfusion, but they fail to prevent inflammatory responses during ..
  62. doi Early use of vasopressors after injury: caution before constriction
    Jason L Sperry
    Division of Burn, Trauma, Critical Care, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    J Trauma 64:9-14. 2008
    Recent evidence suggests that overly aggressive crystalloid resuscitation is associated with poor outcome. This has led to a renewed interest in the use of vasopressors for hemodynamic support during resuscitation after injury...
  63. ncbi Resuscitation with 100% O2 increases cerebral injury in hypoxemic piglets
    Berit H Munkeby
    Department of Pediatric Research, Rikshospitalet University Hospital, N 0027 Oslo, Norway
    Pediatr Res 56:783-90. 2004
    ..Perinatal asphyxia is a major cause of immediate and postponed brain injury in the newborn. We hypothesized that resuscitation with 100% O2 compared with ambient air is detrimental to the cerebral tissue...
  64. ncbi Cerebral resuscitation potentials for cardiac arrest
    Peter Safar
    Safar Center for Resuscitation Research, Department of Anesthesiology and Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Crit Care Med 30:S140-4. 2002
    Permanent brain damage after cardiac arrest and resuscitation is determined by many factors, predominantly arrest (no-flow) time, cardiopulmonary resuscitation (low-flow) time, and temperature...
  65. pmc Resuscitation of haemorrhagic shock with normal saline vs. lactated Ringer's: effects on oxygenation, extravascular lung water and haemodynamics
    Charles R Phillips
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, Oregon Health and Science University, Physicians Pavilion, Suite 340, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA
    Crit Care 13:R30. 2009
    Pulmonary oedema and impairment of oxygenation are reported as common consequences of haemorrhagic shock and resuscitation (HSR)...
  66. ncbi Characterization of a hyperdynamic murine model of resuscitated sepsis using echocardiography
    S M Hollenberg
    Section of Critical Care Medicine, Rush Presbyterian St Luke s Medical Center, Chicago, Illinois 60612, USA
    Am J Respir Crit Care Med 164:891-5. 2001
    ..Precise determination of serial hemodynamics in this model may be useful to elucidate pathophysiologic mechanisms and to evaluate new therapies for septic shock...
  67. pmc Damage control resuscitation is associated with a reduction in resuscitation volumes and improvement in survival in 390 damage control laparotomy patients
    Bryan A Cotton
    Department of Surgery, The University of Texas Health Science Center, Houston, TX, USA
    Ann Surg 254:598-605. 2011
    To determine whether implementation of damage control resuscitation (DCR) in patients undergoing damage control laparotomy (DCL) translates into improved survival.
  68. ncbi Lactated Ringer's is superior to normal saline in the resuscitation of uncontrolled hemorrhagic shock
    S Rob Todd
    Methodist Hospital, Houston, TX 77030, USA
    J Trauma 62:636-9. 2007
    Normal saline (NS) and lactated Ringer's solution (LR) continue to be used interchangeably for the resuscitation of hemorrhagic shock in some institutions...
  69. ncbi A complication of transtracheal jet ventilation and use of the Aintree intubation catheter during airway resuscitation
    T M Cook
    Department of Anaesthesia, Royal United Hospital, Bath, UK
    Anaesthesia 61:692-7. 2006
    ..Novel roles of the Aintree intubation catheter and LMA Proseal in this case are discussed. Complications of transtracheal jet ventilation as well as possible methods for avoiding them are also reviewed...
  70. doi Hemostatic resuscitation is neither hemostatic nor resuscitative in trauma hemorrhage
    Sirat Khan
    From the Centre for Trauma Sciences S K, K B, M C, I R, R D, Blizard Institute, Bart s and the London School of Medicine, Queen Mary University of London, London NHS Blood and Transplant S S, John Radcliffe Hospital, Oxford, United Kingdom and Department of Traumatology C G, Oslo University Hospital Ullevaal, Oslo, Norway
    J Trauma Acute Care Surg 76:561-7; discussion 567-8. 2014
    ..Hemostatic (or damage control) resuscitation developed from the discovery of acute traumatic coagulopathy and increased recognition of the negative ..
  71. ncbi New airways for resuscitation?
    T M Cook
    Department of Anaesthesia, Royal United Hospital, Combe Park, Bath BA1 3NG, UK
    Resuscitation 69:371-87. 2006
    ..In contrast for resuscitation, both in and outside hospital, facemask ventilation and tracheal intubation remain the mainstays of airway ..
  72. doi Severe controlled hemorrhage resuscitation with small volume poloxamer 188 in sedated miniature swine
    John W Burns
    U S Army Institute of Surgical Research, Ft Sam Houston, TX 78234 6315, USA
    Resuscitation 82:1453-9. 2011
    ..This study used P188 as a small volume resuscitation product in a sedated, sexually mature, male miniature swine severe hemorrhage model for potential improvement ..
  73. pmc Variation in out-of-hospital cardiac arrest resuscitation and transport practices in the Resuscitation Outcomes Consortium: ROC Epistry-Cardiac Arrest
    Dana Zive
    Department of Emergency Medicine, Oregon Health and Science University, Portland, OR 97239, United States
    Resuscitation 82:277-84. 2011
    ..variation in transport practices in relation to documented prehospital return of spontaneous circulation (ROSC) within eight regional clinical centers participating in the Resuscitation Outcomes Consortium (ROC) Epistry-Cardiac Arrest.
  74. pmc Factors affecting pediatric isotonic fluid resuscitation efficiency: a randomized controlled trial evaluating the impact of syringe size
    Greg Harvey
    Department of Pediatrics, McMaster Children s Hospital, McMaster University, Hamilton, ON, Canada
    BMC Emerg Med 13:14. 2013
    Goal-directed therapy guidelines for pediatric septic shock resuscitation recommend fluid delivery at speeds in excess of that possible through use of regular fluid infusion pumps...
  75. pmc Acute alcohol intoxication reduces mortality, inflammatory responses and hepatic injury after haemorrhage and resuscitation in vivo
    B Relja
    Department of Trauma Surgery, Johann Wolfgang Goethe University Frankfurt am Main, Germany
    Br J Pharmacol 165:1188-99. 2012
    Haemorrhagic shock and resuscitation (H/R) induces hepatic injury, strong inflammatory changes and death. Alcohol intoxication is assumed to worsen pathophysiological derangements after H/R...
  76. pmc Implementing a simplified neonatal resuscitation protocol-helping babies breathe at birth (HBB) - at a tertiary level hospital in Nepal for an increased perinatal survival
    K C Ashish
    International Maternal and Child Health, Department of Women s and Children s Health, Uppsala University, Uppsala, Sweden
    BMC Pediatr 12:159. 2012
    ..This study will assess the impact of a simplified neonatal resuscitation protocol provided by Helping Babies Breathe (HBB) at a tertiary hospital in Nepal...
  77. pmc Damage control resuscitation: history, theory and technique
    Chad G Ball
    From the University of Calgary and Foothills Medical Centre, Calgary, Alta
    Can J Surg 57:55-60. 2014
    Damage control resuscitation (DCR) represents the natural evolution of the initial concept of damage control surgery. It currently includes early blood product transfusion, immediate arrest and/or temporization of ongoing hemorrhage (i.e...
  78. doi Hypotensive resuscitation strategy reduces transfusion requirements and severe postoperative coagulopathy in trauma patients with hemorrhagic shock: preliminary results of a randomized controlled trial
    C Anne Morrison
    Department of Surgery, Baylor College of Medicine, Houston, Texas, USA
    J Trauma 70:652-63. 2011
    ..that limiting the amount of fluids given by following a strategy of permissive hypotension during the initial resuscitation period may improve trauma outcomes...
  79. doi Recombinant human erythropoietin improves gut barrier function in a hemorrhagic shock and resuscitation rat model
    N Raymond L C Kao
    Canadian Forces Health Services, Department of National Defence, Ottawa, Ontario, Canada
    J Trauma 71:S456-61. 2011
    ..Erythropoietin (EPO) can exert hemodynamic, anti-inflammatory, and tissue protective effects. We tested the hypothesis that EPO given at the time of resuscitation with saline will reduce functional ileal injury 24 hours after shock.
  80. doi Auditing resuscitation of preterm infants at birth by recording video and physiological parameters
    Kim Schilleman
    Department of Pediatrics, Division of Neonatology, Leiden University Medical Center, Leiden, The Netherlands
    Resuscitation 83:1135-9. 2012
    To evaluate compliance with neonatal resuscitation guidelines during resuscitation of preterm infants by video recording of delivery room management and monitoring physiologic parameters.
  81. doi Plasma-Lyte 148 vs 0.9% saline for fluid resuscitation in diabetic ketoacidosis
    Horng Ruey Chua
    Department of Intensive Care, Austin Hospital, Melbourne, Australia
    J Crit Care 27:138-45. 2012
    The purpose of the study was to determine the effects of Plasma-Lyte 148 (PL) vs 0.9% saline (NS) fluid resuscitation in diabetic ketoacidosis (DKA).
  82. doi A new paradigm for human resuscitation research using intelligent devices
    Charles F Babbs
    Department of Basic Medical Sciences, Purdue University 1246 Lynn Hall, West Lafayette, IN 47907 1246, USA
    Resuscitation 77:306-15. 2008
    To develop new methods for studying correlations between the performance and outcome of resuscitation efforts in real-world clinical settings using data recorded by automatic devices, such as automatic external defibrillators (AEDs), and ..
  83. ncbi Spectral analysis of ventricular fibrillation and closed-chest cardiopulmonary resuscitation
    H U Strohmenger
    Department of Anesthesiology and Critical Care Medicine, University of Ulm, Germany
    Resuscitation 33:155-61. 1996
    This study was designed to assess the interference by closed-chest cardiopulmonary resuscitation (CPR) on the ventricular fibrillation (VF) ECG signal in a porcine model of cardiac arrest and to elucidate which variable of VF spectral ..
  84. pmc Circulating levels of cytochrome c after resuscitation from cardiac arrest: a marker of mitochondrial injury and predictor of survival
    Jeejabai Radhakrishnan
    Division of Critical Care Medicine, Department of Medicine, Rosalind Franklin University of Medicine and Science, and North Chicago Veterans Affairs Medical Center, North Chicago, Illinois, USA
    Am J Physiol Heart Circ Physiol 292:H767-75. 2007
    ..We hypothesized that mitochondrial injury occurs during cardiac resuscitation, causing release of cytochrome c to the cytosol and bloodstream while activating apoptotic pathways...
  85. pmc Hypertonic saline resuscitation improves intestinal microcirculation in a rat model of hemorrhagic shock
    El Rasheid Zakaria
    Department of Physiology and Biophysics, University of Louisville, Louisville, KY, USA
    Surgery 140:579-87; discussion 587-8. 2006
    Conventional resuscitation (CR) from hemorrhagic shock (HS) often restores and maintains hemodynamics but fails to restore intestinal perfusion...
  86. ncbi Small volume resuscitation: a randomized controlled trial with either norepinephrine or vasopressin during severe hemorrhage
    Patrick Meybohm
    Department of Anaesthesiology and Intensive Care Medicine, University Hospital Schleswig Holstein, Campus Kiel, Germany
    J Trauma 62:640-6. 2007
    ....
  87. doi Limb ischemic preconditioning mitigates lung injury induced by haemorrhagic shock/resuscitation in rats
    Woan Ching Jan
    Department of Nursing, Mackay Medicine, Nursing and Management College, Taipei, Taiwan
    Resuscitation 82:760-6. 2011
    Haemorrhagic shock and subsequent resuscitation induce acute lung injury. We elucidated whether bilateral lower limb ischemic pre-conditioning (IP) could mitigate lung injury in haemorrhagic shock/resuscitation rats...
  88. doi Colloids versus crystalloids for fluid resuscitation in critically ill patients
    Pablo Perel
    Cochrane Injuries Group, London School of Hygiene and Tropical Medicine, London, UK
    Cochrane Database Syst Rev 2:CD000567. 2013
    Colloid solutions are widely used in fluid resuscitation of critically ill patients. There are several choices of colloid, and there is ongoing debate about the relative effectiveness of colloids compared to crystalloid fluids.
  89. pmc Translating resuscitation guidelines into practice: health care provider attitudes, preferences and beliefs regarding pediatric fluid resuscitation performance
    Melissa J Parker
    Department of Pediatrics, McMaster Children s Hospital and McMaster, University, Hamilton, Ontario, Canada
    PLoS ONE 8:e58282. 2013
    Children who require fluid resuscitation for the treatment of shock present to tertiary and non-tertiary medical settings. While timely fluid therapy improves survival odds, guidelines are poorly translated into clinical practice...
  90. ncbi Vasopressin, but not fluid resuscitation, enhances survival in a liver trauma model with uncontrolled and otherwise lethal hemorrhagic shock in pigs
    Karl H Stadlbauer
    Department of Anesthesiology and Critical Care Medicine, Leopold Franzens University, Innsbruck, Austria
    Anesthesiology 98:699-704. 2003
    The authors compared the effects of vasopressin fluid resuscitation on survival in a liver trauma model with uncontrolled and otherwise lethal hemorrhagic shock in pigs.
  91. doi Team training in the neonatal resuscitation program for interns: teamwork and quality of resuscitations
    Eric J Thomas
    6410 Fannin St, UPB 1100, Houston, TX 77030, USA
    Pediatrics 125:539-46. 2010
    Poor communication and teamwork may contribute to errors during neonatal resuscitation. Our objective was to evaluate whether interns who received a 2-hour teamwork training intervention with the Neonatal Resuscitation Program (NRP) ..
  92. ncbi Controlled resuscitation for uncontrolled hemorrhagic shock
    D Burris
    Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814 4799, USA
    J Trauma 46:216-23. 1999
    To test the hypothesis that controlled resuscitation can lead to improved survival in otherwise fatal uncontrolled hemorrhage.
  93. pmc Mortality after fluid bolus in children with shock due to sepsis or severe infection: a systematic review and meta-analysis
    Nathan Ford
    Medecins Sans Frontieres, Geneva, Switzerland
    PLoS ONE 7:e43953. 2012
    ..We conducted a systematic review to assess the evidence base for fluid resuscitation in the treatment of children with shock due to sepsis or severe infection.
  94. doi Normoxic ventilatory resuscitation following controlled cortical impact reduces peroxynitrite-mediated protein nitration in the hippocampus
    Edward S Ahn
    Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, Maryland, USA
    J Neurosurg 108:124-31. 2008
    Ventilatory resuscitation with 100% O2 after severe traumatic brain injury (TBI) raises concerns about the increased production of reactive oxygen species (ROS)...
  95. doi Manual ventilation devices in neonatal resuscitation: tidal volume and positive pressure-provision
    Charles C Roehr
    Clinic of Neonatology, Charite Universitatsmedizin Berlin, Chariteplatz 1, 10117 Berlin, Germany
    Resuscitation 81:202-5. 2010
    ..We compared the influence of different manual ventilation devices and individual professional experience on the extent of applied Vt and PIP in simulated neonatal resuscitation.
  96. ncbi Impact of a bicarbonated saline solution on early resuscitation after major burns
    M M Berger
    Soins intensifs de chirurgie, CHUV, Lausanne, Switzerland
    Intensive Care Med 26:1382-5. 2000
    The study aimed at assessing the impact of the introduction of a bicarbonated saline solution on total fluid load, weight gain and acid base status during acute burn resuscitation.
  97. pmc Comparative effectiveness of inhospital trauma resuscitation at a French trauma center and matched patients treated in the United States
    Adil H Haider
    Center for Surgery Trials and Outcomes Research, Department of Surgery, The Johns Hopkins School of Medicine, Baltimore, MD 21212, USA
    Ann Surg 258:178-83. 2013
    ..The objective of this paper is to compare mortality outcomes between patients treated at a trauma center in France and matched patients in the United States...
  98. pmc Hypertonic resuscitation modulates the inflammatory response in patients with traumatic hemorrhagic shock
    Eileen M Bulger
    Department of Surgery, University of Washington, Harborview Medical Center, Seattle, WA 98104, USA
    Ann Surg 245:635-41. 2007
    To determine the effect of resuscitation with hypertonic saline/dextran (HSD) on the innate immune response after injury.
  99. doi Video review using a reliable evaluation metric improves team function in high-fidelity simulated trauma resuscitation
    Nicholas Allen Hamilton
    Department of Surgery, Washington University, Saint Louis, Missouri, USA
    J Surg Educ 69:428-31. 2012
    To demonstrate that instruction of proper team function can occur using high-fidelity simulated trauma resuscitation with video-assisted debriefing and that this process can be integrated rapidly into a standard general surgery curriculum.
  100. doi Crystalloid resuscitation improves survival in trauma patients receiving low ratios of fresh frozen plasma to packed red blood cells
    Nicholas Spoerke
    Division of Trauma and Critical Care, Oregon Health and Science University, Portland, Oregon 97239, USA
    J Trauma 71:S380-3. 2011
    Current trauma resuscitation guidelines recommend giving an initial crystalloid bolus as first line for resuscitation...
  101. doi The acute effects of acetate-balanced colloid and crystalloid resuscitation on renal oxygenation in a rat model of hemorrhagic shock
    Emre Almac
    Department of Translational Physiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Resuscitation 83:1166-72. 2012
    Fluid resuscitation therapy is the initial step of treatment for hemorrhagic shock...

Research Grants68

  1. Direct Peritoneal Resuscitation from Hypovolemic Shock
    Richard Garrison; Fiscal Year: 2007
    ..It is hypothesize that initiation of direct intraperitoneal resuscitation (DPR) with a balanced physiologic salt solution supplemented with glucose (2...
  2. Prevention of Acute Lung Injury by IL-6 activated STAT3
    Ana Moran; Fiscal Year: 2010
    ..cells within the lung were AECs;AEC apoptosis increased with increasing duration of hypotension and required resuscitation. IL-6 administered at the start of resuscitation completely prevented T/HS-induced lung AEC apoptosis, ..
  3. Peroxynitrite Decomposition Catalyst and Nitric Oxide Donor for Endotoxemia
    GARRY JOHN SOUTHAN; Fiscal Year: 2012
    ..In an LD100 murine model of endotoxinemia, resuscitation by R-100 starting 1 h after lipopolysaccharide (LPS) challenge produces 100% survival, accompanied by near ..
  4. A Bifunctional Katp Channel Activator and Redox Mimetic for BPD
    Kanneganti Murthy; Fiscal Year: 2013
    ..In a murine model of hypohalous redox lung injury induced by Cl2 inhalation, R-801 resuscitation reduced histologic injury, diminished neutrophil (PMN) infiltration, blocked nuclear translocation of NF-kB, ..
  5. Intrathoracic Pressure Regulator for Resuscitation
    Keith G Lurie; Fiscal Year: 2011
    ..As such, this new device has the potential to be an important new advance in treating life-threatening hypotension and thereby reduce civilian and military mortality rates. ..
  6. PARP inhibitor and Redox Catalyst Conjugate for Traumatic Brain Injury
    Kanneganti Murthy; Fiscal Year: 2012
    ..A resuscitation paradigm will be employed, whereby therapeutic agents will be introduced 2 h after cortical contusion and ..
  7. Resuscitation of smoke inhalation and burn injury with a thioredoxin mimetic
    ANDREW LURIE SALZMAN; Fiscal Year: 2012
    ..b>Resuscitation with R-901, NAC, or vehicle control will be initiated 1 h after thermal insult and continued for 48 h, a ..
  8. PARP Inhibitor and Redox Catalyst for Ventilatory Trauma
    Prakash Jagtap; Fiscal Year: 2013
    ..In murine LD100 models of zymosan-induced multiple organ failure (MOF) and Cl2 inhalational lung injury, resuscitation with R-503 begun after the onset of zymosan instillation or Cl2 inhalation reduced neutrophil (PMN) ..
  9. New drug Vida-5 for treating chronic kidney disease progression
    Jinshyun Ruth Wu-Wong; Fiscal Year: 2011
    ..There is an urgent medical need for the development of an effective and novel resuscitation approach for the treatment of CKD...
  10. Novel drug VS-105 for treatment of diabetic nephropathy
    Jinshyun Ruth Wu-Wong; Fiscal Year: 2012
    ..There is an urgent medical need for the development of an effective and novel resuscitation approach for the treatment of diabetic nephropathy...
  11. Energy Balance During Ketosis in Rat Brain
    JOSEPH CHARLES LAMANNA; Fiscal Year: 2010
    ..It is known that cerebral ischemia, such as stroke (induced by cardiac arrest and resuscitation), results in altered glucose metabolism, the reduction of intracellular energy metabolites such as ATP, ADP ..
  12. Therapeutic Strategies for Neonatal Hypoxic-Ischemic Encephalopathy
    RAYMOND CHARLES KOEHLER; Fiscal Year: 2012
    ..In Aim 1, the effect of treatment with an A2A antagonist after cardiac resuscitation from HI will be studied on DARPP-32, NR1, and Na,K-ATPase phosphorylation, Na,K-ATPase activity, superoxide ..
  13. Bifunctional Redox Catalyst &Organic Nitrate for Limb Reperfusion
    ANDREW LURIE SALZMAN; Fiscal Year: 2013
    ..In a Phase 1 SBIR, we demonstrated in a severe murine model of acute LIRI that R-100 resuscitation profoundly reduces limb histologic damage, lipid peroxidation, neutrophil infiltration, and % of injured ..
  14. Human hepatocytes for drug toxicity screening from Cardiac Death Donor livers
    Mark G Clemens; Fiscal Year: 2012
    ..isolated from non-transplantable DCD livers through the modification of a hypothermic machine perfusion (HMP) resuscitation system that we have developed to restore function to ischemia damaged DCD livers for use in transplantation...
  15. Heme Oxygenase Enzymes/Carbon Monoxide in Hepatic Dysfunction from hemorrhage
    BRIAN SCOTT ZUCKERBRAUN; Fiscal Year: 2013
    ..mechanism(s) of CO when delivered exogenously as a therapeutic in models of acute severe hemorrhage and resuscitation. Our studies concentrate on the influence of HO enzymes and CO within the liver and hepatocytes, as hepatic ..
  16. Impact of Temperature Profile on Outcome After Traumatic Brain Injury
    Lori Kennedy Madden; Fiscal Year: 2013
    ..and treat patient body temperature, this research has the potential to influence rewarming rates in trauma resuscitation with TBI, temperature management goals after TBI, and timing of interventions to prevent/minimize fever after ..
  17. Novel non-invasive device for treatment of elevated intracranial pressures
    Keith G Lurie; Fiscal Year: 2011
    ..and potentially lethal brain injury helped to maintain metabolic stability of the brain better than standard resuscitation fluid alone;2) Incorporated an intrathoracic pressure vacuum gauge into the ITPR system and begun work on a ..
  18. Therapeutic Potential of PARP inhibitor for Acute Pancreatitis
    Latha Paka; Fiscal Year: 2010
    ..Standard therapy for patients with severe disease includes early invasive monitoring and resuscitation, prophylactic antibiotics, nutrition, and serial CT scanning to identify infection and necrosis...
  19. Radiocontrast Nephropathy: Redox Degradation Catalyst and Nitric Oxide Donor
    ZSUZSANNA KINGA ZSENGELLER; Fiscal Year: 2013
    ..may be obtained in the diabetic setting by combining the administration of R-100 with aggressive volume resuscitation. Aim #2: Establish the pharmacokinetics (PK) of R-100 in a rodent model of CIN We will carry out PK studies in ..
  20. Age-dependent microglial responses in hypoxia-ischemia
    PETER A FERRAZZANO; Fiscal Year: 2013
    ..Externships to the Vexler Lab at UCSF and the Clark Lab at the Safar Center for Resuscitation Research will provide training in new techniques for assessing neuronal cell death and for assessing and ..
  21. Novel bundled mechanical and pharmacological CPR platform
    Anja Metzger; Fiscal Year: 2012
    ..to the brain and other vital organs during CPR, especially when combined in an overall systems-based approach to pre and post-resuscitation care, has the potential to significantly reduce morbidity and mortality from cardiac arrest.
  22. Mechanisms and translation of lipid resuscitation
    Guy L Weinberg; Fiscal Year: 2013
    ..Intravenous lipid emulsion (ILE) resuscitation has also been used in many instances to rapidly reverse acute cardiac and neurological symptoms of toxicity ..
  23. Resuscitation using novel impedance threshold devices in pediatrics
    Keith G Lurie; Fiscal Year: 2013
    ..Rapid, large volume crystalloid infusion and positive intrathoracic pressure ventilation resuscitation strategies often increase morbidity and mortality following hemorrhage...
  24. Regulated Hypothermia to Treat Hypoxic-Ischemic Brain Injury
    Laurence M Katz; Fiscal Year: 2010
    ..regulated to forced hypothermia for time to target temperature, survival and neurological outcome after resuscitation from brain ischemia...
  25. Physiology and Biophysics of Cardiac Slo2.1 Channels
    Alexey V Zaitsev; Fiscal Year: 2012
    ..and the left ventricle (RV and LV), which are highly relevant to the outcomes of defibrillation and post-shock resuscitation. Yet the exact mechanism of these gradients remains a puzzle...
  26. Keratin biomaterial-based fluid for trauma resuscitation
    LUKE BURNETT; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): This is a proposal to develop a keratin based resuscitation fluid that greatly improves outcomes for patients following treatment of hemorrhage...
  27. Resuscitation Outcomes Consortium (ROC) Regional Clinical Centers-Milwaukee
    TOM PAUL AUFDERHEIDE; Fiscal Year: 2013
    Description (provided by applicant): The Resuscitation Outcomes Consortium (ROC), consisting of 9 Regional Clinical Centers and a Data and Coordinating Center, is conducting multiple collaborative trials to achieve its long-term ..
  28. Resuscitation Outcomes Consortium (ROC) Regional Clinical Center-Seattle-King
    PETER JAMES KUDENCHUK; Fiscal Year: 2013
    Description (provided by applicant): The Resuscitation Outcomes Consortium (ROC), consisting of 9 Regional Clinical Centers and a Data and Coordinating Center, is conducting multiple collaborative trials to achieve its long-term ..
  29. Resuscitation Outcomes Consortium (ROC) Regional Clinical Center-Pittsburgh
    Clifton W Callaway; Fiscal Year: 2013
    Description (provided by applicant): The Resuscitation Outcomes Consortium (ROC), consisting of 9 Regional Clinical Centers and a Data and Coordinating Center, is conducting multiple collaborative trials to achieve its long-term ..
  30. Improvement of Organ Function after Severe Hypovolemia
    Ping Wang; Fiscal Year: 2013
    ..blood loss or from the development of inflammation, infection, and organ damage after seemingly "adequate" resuscitation. Clinical management of hemorrhagic shock relies on massive and rapid infusion of fluids to maintain blood ..
  31. MAINTENANCE OF ORGAN FUNCTION FOLLOWING INJURY
    Irshad H Chaudry; Fiscal Year: 2012
    ..depressed in males, but not in proestrus females (with high estrogen [E2] levels) after trauma-hemorrhage and resuscitation (T-H)...
  32. A NEW TECHNIQUE FOR TREATING HEMORRHAGIC SHOCK
    Sufan Chien; Fiscal Year: 2013
    ..specific aims of this proposal are to use a newly developed intracellular energy delivery technique to enhance resuscitation, and to study the relationship between tissue high-energy phosphate supplementation and tissue necrosis and ..
  33. Oxidative stress in regional cerebral blood flow alterations after cardiac arrest
    Mioara D Manole; Fiscal Year: 2012
    ..Most survivors have severe neurological impairment. Cerebral blood flow (CBF) disturbances after resuscitation may further contribute to neuropathological damage after cardiac arrest...
  34. SK2 Channels as Novel Neuroprotective Targets Against Cerebral Ischemia
    Paco S Herson; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Cardiac arrest/cardiopulmonary resuscitation (CA/CPR) causes ischemia, neuronal excitotoxicity and cognitive decline. Despite intensive efforts, outcome remains poor...
  35. CaMKII in global cerebral ischemia
    Paco S Herson; Fiscal Year: 2013
    ..Each year in the United States ~600,000 people suffer from cardiac arrest (CA) and receive cardiopulmonary resuscitation (CPR), resulting in hypoxia-ischemia (HI) of the brain and consequently in severe neurological deficits in ..
  36. Biologic Evaluation of Liposome-Encapsulated Hemoglobin
    Vibhudutta Awasthi; Fiscal Year: 2013
    ..Much of the mortality may be prevented by the timely availability of a safe and uni- versal resuscitation fluid...
  37. Prompt Diagnosis and Treatment of Subclinical Seizures After Cardiac Arrest
    Alexis A Topjian; Fiscal Year: 2013
    ..She aspires to become an independent neuroscientist focusing on post-resuscitation care...
  38. Role of Serotonin in Smypathetic Function
    Karie E Scrogin; Fiscal Year: 2012
    ..of the venous vasculature induced by 5-HT1A receptor activation will produce less reperfusion injury during resuscitation from hypovolemic shock than clinically used vasoconstrictor agents which tend to constrict arterial vascular ..
  39. New drug VS-501 for treating hyperphosphatemia in chronic kidney disease
    Jinshyun Ruth Wu-Wong; Fiscal Year: 2012
    ..There is an urgent medical need for the development of an effective and novel resuscitation approach for the treatment of CKD...
  40. Neurological and cognitive effects of hyperoxia after cardiac arrest
    STEPHEN WALTER TRZECIAK; Fiscal Year: 2013
    ..S. Even if resuscitation achieves return of spontaneous circulation (ROSC), >50% of patients suffer fatal or crippling brain injury...
  41. Pyruvate: Powerful Brain Protection after Cardiac Arrest
    Robert T Mallet; Fiscal Year: 2013
    ..Moreover, intravenous pyruvate infusion during cardiopulmonary resuscitation (CPR) prevented subsequent neurological impairment and neuronal apoptosis 3 days after cardiac arrest...
  42. THAPCA Trials - DCC Application
    JONATHAN MICHAEL DEAN; Fiscal Year: 2013
    ..THAPCA is highly relevant to the mission of the NHLBI, and complements the NHLBI Resuscitation Outcomes Consortium (ROC)...
  43. THAPCA Trials - Scientific Application
    Frank W Moler; Fiscal Year: 2012
    ..THAPCA is highly relevant to the mission of the NHLBI, and complements the NHLBI Resuscitation Outcomes Consortium (ROC)...
  44. IMPACT OF HYDROGEN SULFIDE ON OUTCOME OF CARDIAC ARREST AND CARDIOPULMONARY RESUS
    Fumito Ichinose; Fiscal Year: 2013
    ..Despite advances in cardiopulmonary resuscitation (CPR) methods, 60-80% of these arrests result in immediate death, and of the remaining, only about 5 percent ..
  45. Protocolized Care for Early Septic Shock (ProCESS)
    Derek C Angus; Fiscal Year: 2012
    ..They demonstrated in a single center randomized trial that 6 h of protocolized resuscitation for subjects presenting to the Emergency Department (ED) with early septic shock dramatically improved ..
  46. Carbon Monoxide Therapy to Prevent Circulatory Collapse and Shock From Hemorrhage
    BRIAN SCOTT ZUCKERBRAUN; Fiscal Year: 2013
    ..Thus, the development of adjuncts to standard care and resuscitation that can be instituted in the field early in the care of these civilians and active duty soldiers has the ..
  47. Mechanisms of Hypothermic Protection from Ischemia/Reperfusion Cardiac Injury
    Kimm J Hamann; Fiscal Year: 2010
    Therapeutic hypothermia can significantly attenuate post-resuscitation injury and improve survival in some patients. In our cellular and animal models of global ischemia, there is significant post-resuscitation cardiac injury...
  48. Thiamine as a Metabolic Resuscitator in Septic Shock
    Michael William Donnino; Fiscal Year: 2012
    ..Whether the provision of thiamine to patients in septic shock would provide a form of metabolic resuscitation through improving the efficacy of pyruvate dehydrogenase remains unknown...
  49. Role of IbpA in maintaining viability of P. aeruginosa biofilm persister cells
    Michael J Franklin; Fiscal Year: 2012
    ..Using ibpA and rpoH deletion mutants, we will determine the role of IbpA in allowing resuscitation of dormant cells exposed to stresses, including aging, oxidizing agents, and antibiotics...
  50. 12/15-Lipoxygenase and neurovascular damage following cardiac arrest
    Klaus van Leyen; Fiscal Year: 2013
    ..preliminary results show that a) expression of 12/15-LOX is increased in a mouse model of cardiac arrest and resuscitation;b) 12/15-LOX co-localizes with MDA2, a marker for oxidative stress, as well as FluoroJade B, a marker for ..
  51. Extracorporeal Support for Emergent (Uncontrolled) Donation Following Cardiac Dea
    Shawn J Pelletier; Fiscal Year: 2010
    ..In many situations, patients have suffered either fatal traumatic injury or unexpected cardiac arrest. Resuscitation is attempted until it is deemed futile in reestablishing circulation, a determination that is made by ..
  52. MOUNT SINAI EMERGENCY MEDICINE RESEARCH CAREER DEVELOPMENT PROGRAM
    Lynne D Richardson; Fiscal Year: 2013
    ..research expertise in the exception from informed consent regulations that allow clinical investigations of resuscitation and other life-threatening conditions and other faculty members will address specific regulatory requirements ..
  53. Late cardiovascular consequences of septic shock
    Sachin Yende; Fiscal Year: 2013
    ..Aim #3 will determine whether alternative cardiovascular resuscitation strategies that are known to affect the initial immune response will improve immune resolution after discharge ..
  54. SIMLAB: Using Patient Simulation for Student Exploration of Community Health Issu
    PATRICIA LEAH WARD; Fiscal Year: 2013
    ..has a heartbeat and a pulse, and accurately mirrors human responses to such procedures as cardio-pulmonary resuscitation, intravenous medication, intubation, ventilation, and catheterization...
  55. Keratin biomaterial-based fluid for trauma resuscitation
    LUKE RUSSELL BURNETT; Fiscal Year: 2013
    ..made in the treatment of severe hemorrhage, current blood plasma substitutes do not address new insights in resuscitation medicine...
  56. The SAIL trial [Sustained Aeration of Infant Lungs]
    Sarah J Ratcliffe; Fiscal Year: 2013
    ..They are collectively expert in ventilation or delivery room resuscitation or both...
  57. Chemotherapy Near Death: Modifiable Factors and Outcomes in Ovarian Cancer
    Alexi Wright; Fiscal Year: 2013
    ..5 months before death, had 8-fold higher odds of undergoing ventilation or resuscitation in the last week of life, compared with patients who did not...
  58. Nitrite based neuroprotection after cardiac arrest
    Cameron Dezfulian; Fiscal Year: 2013
    ..Dezfulian is an adult and pediatric critical care physician acutely aware of the paucity of post-resuscitation therapies for the cardiac arrest survivors he cares for...
  59. Intrathoracic Pressure Regulation for the Treatment of Septic Shock
    Keith Lurie; Fiscal Year: 2009
    ..and shown to increase circulation and survival rates in hemorrhagic shock and cardiac arrest, during the early resuscitation phase of sepsis...
  60. Planning Grant for PRESOX Trial
    Neil Finer; Fiscal Year: 2009
    ..To conduct a prospective randomized multi-center clinical trial to evaluate the potential benefit of neonatal resuscitation using a targeted oxygen strategy initiated with a low oxygen concentration of 30% (LOWOX) compared to with the ..
  61. CONTROL OF CEREBRAL REPERFUSION AFTER CARDIAC ARREST
    Peter Safar; Fiscal Year: 1990
    ..After cardiac arrest (CA) of more than 5 min and cardiopulmonary resuscitation (CPR), however, the "post- resuscitation syndrome" of multiple organ systems normally precludes cerebral ..
  62. Cell Survival in Brain Reperfusion
    Jonathon Sullivan; Fiscal Year: 2004
    ..Insulin administration at resuscitation from cardiac arrest induces dephosphorylation of eIF2alpha(P) and rescue of protein synthesis in vulnerable ..
  63. PHARMACOLOGY OF ANESTHETICS IN HEMORRHAGIC SHOCK
    Ken Johnson; Fiscal Year: 2002
    ..The goal of this grant is to investigate the influence of hemorrhagic shock and fluid resuscitation on the pharmacokinetic and pharmacodynamic properties of a short and long acting opioid, neuromuscular blocker,..