electric stimulation therapy

Summary

Summary: Application of electric current in treatment without the generation of perceptible heat. It includes electric stimulation of nerves or muscles, passage of current into the body, or use of interrupted current of low intensity to raise the threshold of the skin to pain.

Top Publications

  1. ncbi Advances and challenges in neurostimulation for headaches
    Delphine Magis
    Headache Research Unit, Department of Neurology, University of Liege, Belgium
    Lancet Neurol 11:708-19. 2012
  2. ncbi Anodal transcranial direct current stimulation of prefrontal cortex enhances working memory
    Felipe Fregni
    Harvard Center for Non Invasive Brain Stimulation, Beth Israel Deaconess Medical Center, Harvard Medical School, 330, Brookline Avenue, KS 452, Boston, MA 02215, USA
    Exp Brain Res 166:23-30. 2005
  3. ncbi Transcranial DC stimulation (tDCS): a tool for double-blind sham-controlled clinical studies in brain stimulation
    Prateek C Gandiga
    Human Cortical Physiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Clin Neurophysiol 117:845-50. 2006
  4. pmc Occipital nerve stimulation for the treatment of intractable chronic migraine headache: ONSTIM feasibility study
    Joel R Saper
    Michigan Head Pain and Neurological Institute, 3120 Professional Drive, Ann Arbor, MI 48104, USA
    Cephalalgia 31:271-85. 2011
  5. ncbi Safety and cognitive effect of frontal DC brain polarization in healthy individuals
    M B Iyer
    Brain Stimulation Unit and Cognitive Neuroscience, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA
    Neurology 64:872-5. 2005
  6. ncbi A sham-controlled, phase II trial of transcranial direct current stimulation for the treatment of central pain in traumatic spinal cord injury
    Felipe Fregni
    Harvard Center for Noninvasive Brain Stimulation, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Pain 122:197-209. 2006
  7. ncbi Relation between stimulation characteristics and clinical outcome in studies using electrical stimulation to improve motor control of the upper extremity in stroke
    Joke R de Kroon
    Roessingh Research and Development Enschede The Netherlands
    J Rehabil Med 37:65-74. 2005
  8. pmc Dual-hemisphere tDCS facilitates greater improvements for healthy subjects' non-dominant hand compared to uni-hemisphere stimulation
    Bradley W Vines
    Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    BMC Neurosci 9:103. 2008
  9. ncbi A randomized, sham-controlled, proof of principle study of transcranial direct current stimulation for the treatment of pain in fibromyalgia
    Felipe Fregni
    Harvard Medical School, Boston, Massachusetts 02215, USA
    Arthritis Rheum 54:3988-98. 2006
  10. ncbi Safety and efficacy of peripheral nerve stimulation of the occipital nerves for the management of chronic migraine: results from a randomized, multicenter, double-blinded, controlled study
    Stephen D Silberstein
    Thomas Jefferson University, Philadelphia, PA, USA
    Cephalalgia 32:1165-79. 2012

Research Grants

Detail Information

Publications312 found, 100 shown here

  1. ncbi Advances and challenges in neurostimulation for headaches
    Delphine Magis
    Headache Research Unit, Department of Neurology, University of Liege, Belgium
    Lancet Neurol 11:708-19. 2012
    ..Trial data for other techniques are scarce, but external and minimally invasive approaches should be privileged in future studies...
  2. ncbi Anodal transcranial direct current stimulation of prefrontal cortex enhances working memory
    Felipe Fregni
    Harvard Center for Non Invasive Brain Stimulation, Beth Israel Deaconess Medical Center, Harvard Medical School, 330, Brookline Avenue, KS 452, Boston, MA 02215, USA
    Exp Brain Res 166:23-30. 2005
    ..Furthermore, this effect depends on the stimulation polarity and is specific to the site of stimulation. This result may be helpful to develop future interventions aiming at clinical benefits...
  3. ncbi Transcranial DC stimulation (tDCS): a tool for double-blind sham-controlled clinical studies in brain stimulation
    Prateek C Gandiga
    Human Cortical Physiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Clin Neurophysiol 117:845-50. 2006
    ..Here, we evaluated the effects of tDCS and sham stimulation (SHAM) on healthy subjects and stroke patients' self-report measures of attention, fatigue, duration of elicited sensations and discomfort...
  4. pmc Occipital nerve stimulation for the treatment of intractable chronic migraine headache: ONSTIM feasibility study
    Joel R Saper
    Michigan Head Pain and Neurological Institute, 3120 Professional Drive, Ann Arbor, MI 48104, USA
    Cephalalgia 31:271-85. 2011
    ..Medically intractable chronic migraine (CM) is a disabling illness characterized by headache ≥15 days per month...
  5. ncbi Safety and cognitive effect of frontal DC brain polarization in healthy individuals
    M B Iyer
    Brain Stimulation Unit and Cognitive Neuroscience, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA
    Neurology 64:872-5. 2005
    ..Activating effects on the frontal lobe might be beneficial for patients with frontal lobe disorders. This phase 1 study tested the safety of frontal DC, including its effects on frontal and other brain functions...
  6. ncbi A sham-controlled, phase II trial of transcranial direct current stimulation for the treatment of central pain in traumatic spinal cord injury
    Felipe Fregni
    Harvard Center for Noninvasive Brain Stimulation, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Pain 122:197-209. 2006
    ..We discuss potential mechanisms for pain amelioration after tDCS, such as a secondary modulation of thalamic nuclei activity...
  7. ncbi Relation between stimulation characteristics and clinical outcome in studies using electrical stimulation to improve motor control of the upper extremity in stroke
    Joke R de Kroon
    Roessingh Research and Development Enschede The Netherlands
    J Rehabil Med 37:65-74. 2005
    ..The aim of this review is to explore the relationship between characteristics of stimulation and the effect of electrical stimulation on the recovery of upper limb motor control following stroke...
  8. pmc Dual-hemisphere tDCS facilitates greater improvements for healthy subjects' non-dominant hand compared to uni-hemisphere stimulation
    Bradley W Vines
    Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    BMC Neurosci 9:103. 2008
    ..Participants performed a finger-sequencing task with the non-dominant hand before and after each stimulation. The dependent variable was the percentage of change in performance, comparing pre- and post-tDCS scores...
  9. ncbi A randomized, sham-controlled, proof of principle study of transcranial direct current stimulation for the treatment of pain in fibromyalgia
    Felipe Fregni
    Harvard Medical School, Boston, Massachusetts 02215, USA
    Arthritis Rheum 54:3988-98. 2006
    ....
  10. ncbi Safety and efficacy of peripheral nerve stimulation of the occipital nerves for the management of chronic migraine: results from a randomized, multicenter, double-blinded, controlled study
    Stephen D Silberstein
    Thomas Jefferson University, Philadelphia, PA, USA
    Cephalalgia 32:1165-79. 2012
    ..Chronic migraine (CM) is a debilitating neurological disorder with few treatment options. Peripheral nerve stimulation (PNS) of the occipital nerves is a potentially promising therapy for CM patients...
  11. ncbi Sustained effectiveness of occipital nerve stimulation in drug-resistant chronic cluster headache
    Delphine Magis
    Headache Research Unit, CHR Citadelle, Department of Neurology, University of Liege, Liege, Belgium
    Headache 51:1191-201. 2011
    ..Recent studies suggest that occipital nerve stimulation (ONS) could be an efficient preventive treatment of drCCH...
  12. ncbi Spinal cord stimulation versus conventional medical management for neuropathic pain: a multicentre randomised controlled trial in patients with failed back surgery syndrome
    Krishna Kumar
    Department of Neurosurgery, Regina General Hospital, 1440 14th Avenue, Regina, Sask, Canada
    Pain 132:179-88. 2007
    ..In selected patients with FBSS, SCS provides better pain relief and improves health-related quality of life and functional capacity compared with CMM alone...
  13. ncbi Treatment of intractable chronic cluster headache by occipital nerve stimulation in 14 patients
    Brian Burns
    Headache Group, Department of Neurology, University of California San Francisco, San Francisco, CA 19143 0114, USA
    Neurology 72:341-5. 2009
    ..Most patients with chronic cluster headache (CCH) have an unremitting illness requiring daily preventive therapy for years...
  14. ncbi Long-term therapeutic and orthotic effects of a foot drop stimulator on walking performance in progressive and nonprogressive neurological disorders
    Richard B Stein
    University of Alberta, Edmonton, Alberta, Canada
    Neurorehabil Neural Repair 24:152-67. 2010
    ..Stimulators applying functional electrical stimulation (FES) to the common peroneal nerve improve walking with a foot drop, which occurs in several disorders...
  15. pmc Central modulation in cluster headache patients treated with occipital nerve stimulation: an FDG-PET study
    Delphine Magis
    University Neurology Department, Liege, Belgium
    BMC Neurol 11:25. 2011
    ..However its mode of action remains elusive. Since the long delay to meaningful effect suggests that ONS induces slow neuromodulation, we have searched for changes in central pain-control areas using metabolic neuroimaging...
  16. ncbi Spinal cord stimulation-induced analgesia: electrical stimulation of dorsal column and dorsal roots attenuates dorsal horn neuronal excitability in neuropathic rats
    Yun Guan
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, School of Medicine, Baltimore, Maryland, USA
    Anesthesiology 113:1392-405. 2010
    ..The sites of action and cellular mechanisms by which spinal cord stimulation reduces neuropathic pain remain unclear...
  17. ncbi Electrical stimulation of sphenopalatine ganglion for acute treatment of cluster headaches
    Mehdi Ansarinia
    The Headache Specialists, Las Vegas, NV, USA
    Headache 50:1164-74. 2010
    ..For this reason, it was selected as a target for an acute neurostimulation study...
  18. ncbi Potential for new technologies in clinical practice
    Jane H Burridge
    Faculty of Health Sciences, University of Southampton, Southampton, UK
    Curr Opin Neurol 23:671-7. 2010
    ..This review presents evidence of new technologies since 2008 and identifies barriers to translation of technologies into clinical practice...
  19. ncbi Behavioural facilitation following brain stimulation: implications for neurorehabilitation
    Giuseppe Vallar
    Department of Psychology, University of Milano Bicocca, and IRCCS Auxological Institute, Milan, Italy
    Neuropsychol Rehabil 21:618-49. 2011
    ....
  20. ncbi Effects of electrical stimulation parameters on fatigue in skeletal muscle
    Ashraf S Gorgey
    Spinal Cord Injury and Disorders Center, Hunter Holmes McGuire VAMC, Richmond, VA 23249, USA
    J Orthop Sports Phys Ther 39:684-92. 2009
    ..Experimental laboratory study...
  21. ncbi Electrical stimulation over the left inferior frontal gyrus (IFG) determines long-term effects in the recovery of speech apraxia in three chronic aphasics
    P Marangolo
    Department of Neuroscience, Faculty of Medicine, University of Ancona, Ancona, Italy
    Behav Brain Res 225:498-504. 2011
    ..At three follow-ups (1 week, 1 and 2 months after the end of treatment), response accuracy was still significantly better in the anodic than in sham condition, suggesting a long-term effect on the recovery of their articulatory gestures...
  22. ncbi Gait in individuals with chronic hemiparesis: one-year follow-up of the effects of a neuroprosthesis that ameliorates foot drop
    Yocheved Laufer
    Department of Physical Therapy, Faculty of Social Welfare and Health Sciences, University of Haifa, Haifa, Israel
    J Neurol Phys Ther 33:104-10. 2009
    ..The objective of this study was to determine the short-term and long-term effects on functional gait of a neuroprosthesis that provides functional electrical stimulation (FES) to correct footdrop...
  23. ncbi A randomized controlled trial of functional neuromuscular stimulation in chronic stroke subjects
    Janis J Daly
    Department of Neurology, Case Western Reserve University, School of Medicine, Cleveland, Ohio, USA
    Stroke 37:172-8. 2006
    ....
  24. pmc Tolerability of transcranial direct current stimulation in childhood-onset schizophrenia
    Anand Mattai
    Child Psychiatry Branch, National Institutes of Health, Bethesda, Maryland 20892, USA
    Brain Stimul 4:275-80. 2011
    ..In recent years, transcranial direct current stimulation (tDCS) has been used to study and treat many neuropsychiatric conditions. However, information regarding its tolerability in the pediatric population is lacking...
  25. ncbi The treatment of medically intractable trigeminal autonomic cephalalgia with supraorbital/supratrochlear stimulation: a retrospective case series
    Julien Vaisman
    Pain and Wellness Center, Peabody, MA 01960, USA
    Neuromodulation 15:374-80. 2012
    ..This is a retrospective case series of five patients with intractable trigeminal autonomic cephalalgia (TAC) who were implanted with a supraorbital/supratrochlear neuromodulation system...
  26. pmc Early neuromuscular electrical stimulation to improve quadriceps muscle strength after total knee arthroplasty: a randomized controlled trial
    Jennifer E Stevens-Lapsley
    Physical Therapy Program, Department of Physical Medicine and Rehabilitation, University of Colorado, Mail Stop C244, 13121 E 17th Ave, Room 3116, Aurora, CO 80045, USA
    Phys Ther 92:210-26. 2012
    ..The recovery of quadriceps muscle force and function after total knee arthroplasty (TKA) is suboptimal, which predisposes patients to disability with increasing age...
  27. ncbi Neurorehabilitation with new functional electrical stimulation for hemiparetic upper extremity in stroke patients
    Yukihiro Hara
    The Department of Rehabilitation Medicine, Nippon Medical School Chiba Hokusoh Hospital, Inba gun, Chiba, Japan
    J Nippon Med Sch 75:4-14. 2008
    ..Nevertheless, evidence-based strategies for motor rehabilitation are more easily available, particularly for patients with hemiparesis...
  28. ncbi Occipital nerve stimulation for the treatment of chronic cluster headache - lessons learned from 18 months experience
    O M Mueller
    University Hospital Essen, Neurosurgery, Essen, Germany
    Cent Eur Neurosurg 72:84-9. 2011
    ..In this study, we present our experiences with bilateral occipital nerve stimulation (ONS) in patients with CCH focusing on patient selection, pre- and postoperative evaluation, surgical procedures, and outcome...
  29. ncbi Neuromuscular electrical stimulation for motor restoration in hemiplegia
    John Chae
    Department of Physical Medicine and Rehabilitation, Case Western Reserve University, Cleveland, Ohio, USA
    Top Stroke Rehabil 15:412-26. 2008
    ..The development of hand neuroprostheses is in its infancy and must await additional fundamental and technical advances before reaching clinical viability. The limitations of available systems and future developments are discussed...
  30. ncbi A rat model for measuring the effectiveness of transcranial direct current stimulation using fMRI
    Yuji Takano
    NTT Communication Science Laboratories, 3 1, Morinosato Wakamiya, Atsugi shi, Kanagawa Pref, 243 0198, Japan
    Neurosci Lett 491:40-3. 2011
    ..This suggests anodal tDCS over the frontal cortex induces neuronal activation in the frontal cortex and in its connected brain region...
  31. ncbi Effects of repetitive electrical stimulation to treat sensory loss in persons poststroke
    Patricia S Smith
    Department of Physical Therapy, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Arch Phys Med Rehabil 90:2108-11. 2009
    ..Smith PS, Dinse HR, Kalisch T, Johnson M, Walker-Batson D. Effects of repetitive electrical stimulation to treat sensory loss in persons poststroke...
  32. ncbi Motor unit recruitment during neuromuscular electrical stimulation: a critical appraisal
    C Scott Bickel
    Department of Physical Therapy, University of Alabama at Birmingham, 1530 3rd Avenue South, Birmingham, AL 35294 1212, USA
    Eur J Appl Physiol 111:2399-407. 2011
    ....
  33. ncbi Feasibility of iterative learning control mediated by functional electrical stimulation for reaching after stroke
    A M Hughes
    School of Health Sciences, University of Southampton, Southampton, United Kingdom
    Neurorehabil Neural Repair 23:559-68. 2009
    ....
  34. ncbi Treatment of refractory chronic cluster headache by chronic occipital nerve stimulation
    Denys Fontaine
    Centre Hospitalier Universitaire de Nice, France
    Cephalalgia 31:1101-5. 2011
    ..Greater occipital nerve stimulation (ONS) has been recently proposed to treat severe chronic cluster headache patients (CCH) refractory to medical treatment. We report the results of a French multidisciplinary cohort study...
  35. ncbi Spinal cord stimulation versus reoperation for failed back surgery syndrome: a cost effectiveness and cost utility analysis based on a randomized, controlled trial
    Richard B North
    Department of Neurosurgery, The Johns Hopkins University, Baltimore, Maryland 21287, USA
    Neurosurgery 61:361-8; discussion 368-9. 2007
    ..We analyzed the cost-effectiveness and cost-utility of treating failed back-surgery syndrome using spinal cord stimulation (SCS) versus reoperation...
  36. ncbi Optimizing parameters for terminating cortical afterdischarges with pulse stimulation
    Gholam K Motamedi
    Department of Neurology, The Johns Hopkins University, Baltimore, Maryland, U S A
    Epilepsia 43:836-46. 2002
    ..We previously reported that brief pulses of electrical stimulation (BPSs) can terminate afterdischarges (ADs) during cortical stimulation. We investigated conditions under which BPS is more likely to suppress ADs...
  37. ncbi Functional electrical stimulation to dorsiflexors and plantar flexors during gait to improve walking in adults with chronic hemiplegia
    David G Embrey
    Good Samaritan Physical Medicine and Rehabilitation Center, Puyallup, WA 98372, USA
    Arch Phys Med Rehabil 91:687-96. 2010
    ..To determine whether functional electrical stimulation (FES) timed to activate the dorsiflexors and plantar flexors during gait improves the walking of adults with hemiplegia...
  38. ncbi Training-induced changes in the pattern of triceps to biceps activation during reaching tasks after chronic and severe stroke
    Ruth Nancy Barker
    Discipline of Physiotherapy, James Cook University, Townsville, Australia
    Exp Brain Res 196:483-96. 2009
    ..The changes in EMG activity were small relative to the changes in arm function indicating that factors, such as the contribution of other muscles of reaching, may also be implicated...
  39. ncbi Disruption of cancer cell replication by alternating electric fields
    Eilon D Kirson
    Department of Biomedical Engineering, NovoCure Ltd, Haifa, Israel
    Cancer Res 64:3288-95. 2004
    ..These findings demonstrate the potential applicability of the described electric fields as a novel therapeutic modality for malignant tumors...
  40. pmc Noninvasive techniques for probing neurocircuitry and treating illness: vagus nerve stimulation (VNS), transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS)
    Mark S George
    Departments of Psychiatry, Radiology and Neuroscience, Institute of Psychiatry, MUSC Center for Advanced Imaging Research, Medical University of South Carolina, Charleston, SC 29425, USA
    Neuropsychopharmacology 35:301-16. 2010
    ..These techniques are transcranial magnetic stimulation, vagus nerve stimulation, and transcranial direct current stimulation. Two of these approaches have FDA approval as therapies...
  41. ncbi The orthotic effect of functional electrical stimulation on the improvement of walking in stroke patients with a dropped foot: a systematic review
    Anke I R Kottink
    Roessingh Research and Development, PO Box 310, 7500 AH Enschede, The Netherlands
    Artif Organs 28:577-86. 2004
    ..Analysis of the available evidence on the improvement of walking in stroke patients with a dropped foot when using peroneus stimulation...
  42. ncbi Deep brain stimulation for Parkinson's disease dissociates mood and motor circuits: a functional MRI case study
    Taresa Stefurak
    Rotman Research Institute, University of Toronto, Toronto, Ontario, Canada
    Mov Disord 18:1508-16. 2003
    ....
  43. ncbi Two coupled motor recovery protocols are better than one: electromyogram-triggered neuromuscular stimulation and bilateral movements
    James H Cauraugh
    Motor Behavior Laboratory, University of Florida, Gainesville 32611, USA
    Stroke 33:1589-94. 2002
    ..With the use of established motor control theories, the present study investigated electromyogram (EMG)-triggered neuromuscular stimulation and bilateral coordination training...
  44. ncbi Peripheral vascular changes after electrically stimulated cycle training in people with spinal cord injury
    H L Gerrits
    Institute for Fundamental and Clinical Human Movement Sciences, Vrije University Amsterdam, Amsterdam, The Netherlands
    Arch Phys Med Rehabil 82:832-9. 2001
    ..To test whether a short period of training leads to adaptations in the cross-sectional area of large conduit arteries and improved blood flow to the paralyzed legs of individuals with spinal cord injury (SCI)...
  45. ncbi Spinal cord stimulation electrode design: prospective, randomized, controlled trial comparing percutaneous and laminectomy electrodes-part I: technical outcomes
    Richard B North
    Department of Neurosurgery, School of Medicine, Johns Hopkins University, Baltimore, Maryland 21287 7713, USA
    Neurosurgery 51:381-9; discussion 389-90. 2002
    ..Contemporary electrodes can be placed percutaneously in some cases and require a limited laminectomy in other cases...
  46. ncbi Temporal cortex direct current stimulation enhances performance on a visual recognition memory task in Alzheimer disease
    P S Boggio
    Center for Health and Biological Sciences, Mackenzie Presbyterian University, Sao Paulo, Brazil
    J Neurol Neurosurg Psychiatry 80:444-7. 2009
    ..As far as is known, this is the first trial showing that tDCS can enhance a component of recognition memory. The potential mechanisms of action and the implications of these results are discussed...
  47. pmc Mechanisms of aphasia recovery after stroke and the role of noninvasive brain stimulation
    Roy H Hamilton
    University of Pennsylvania, Department of Neurology, Center for Cognitive Neuroscience, Philadelphia, United States
    Brain Lang 118:40-50. 2011
    ..We further argue that TMS and tDCS are potentially promising tools for enhancing functional recovery of language and for further elucidating mechanisms of plasticity in patients with aphasia...
  48. ncbi Functional electrical stimulation for neuromuscular applications
    P Hunter Peckham
    Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106, USA
    Annu Rev Biomed Eng 7:327-60. 2005
    ....
  49. ncbi Functional electrical stimulation improves motor recovery of the lower extremity and walking ability of subjects with first acute stroke: a randomized placebo-controlled trial
    Tiebin Yan
    Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hong Kong
    Stroke 36:80-5. 2005
    ..The present study examines whether FES, given during acute stroke, was more effective in promoting motor recovery of the lower extremity and walking ability than standard rehabilitation alone...
  50. ncbi A randomized, placebo-controlled trial of intradiscal electrothermal therapy for the treatment of discogenic low back pain
    Kevin J Pauza
    Texas Spine and Joint Hospital, 1814 Roseland Boulevard, Tyler, TX 75701, USA
    Spine J 4:27-35. 2004
    ..Intradiscal electrothermal therapy (IDET) is a treatment for discogenic low back pain the efficacy of which has not been rigorously tested...
  51. ncbi Subthalamic DBS replaces levodopa in Parkinson's disease: two-year follow-up
    Francois J G Vingerhoets
    Department of Neurology, BH 13, CHUV, CH 1011 Lausanne, Switzerland
    Neurology 58:396-401. 2002
    ..Since antiparkinsonian medication has short- and long-term effects that may prevent an estimate of the maximal possible impact of STN DBS, such medication was used at the lowest possible dosage after DBS implantation...
  52. ncbi Increase in hand muscle strength of stroke patients after somatosensory stimulation
    Adriana B Conforto
    Human Cortical Physiology Section, NINDS, National Institutes of Health, Bethesda, MD 20892 1430, USA
    Ann Neurol 51:122-5. 2002
    ..These results suggest that somatosensory stimulation may be a promising adjuvant to rehabilitation of the motor deficits in stroke patients...
  53. ncbi Effects of somatosensory stimulation on use-dependent plasticity in chronic stroke
    Lumy Sawaki
    Human Cortical Physiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA
    Stroke 37:246-7. 2006
    ..Peripheral nerve stimulation (PNS) modulates motor cortical excitability in healthy humans and could influence training effects in stroke patients...
  54. pmc Musculoskeletal plasticity after acute spinal cord injury: effects of long-term neuromuscular electrical stimulation training
    Richard K Shields
    Graduate Program in Physical Therapy and Rehabilitation Science, The University of Iowa, Iowa City, IA 52242 1190, USA
    J Neurophysiol 95:2380-90. 2006
    ..Importantly, this method of load delivery was feasible and may serve as the basis for an intervention to preserve the musculoskeletal properties of individuals with SCI...
  55. ncbi Transcranial direct current stimulation: electrode montage in stroke
    Hooman Mahmoudi
    Acquired Brain Injury Rehabilitation Centre, Shiraz, Islamic Republic of Iran
    Disabil Rehabil 33:1383-8. 2011
    ..This small sham controlled cross-over clinical trial is important to provide additional data on the clinical effects of tDCS in stroke and for planning and designing future large tDCS trials in patients with stroke...
  56. pmc Continuous low-level vagus nerve stimulation reduces stellate ganglion nerve activity and paroxysmal atrial tachyarrhythmias in ambulatory canines
    Mark J Shen
    Krannert Institute of Cardiology, Division of Cardiology, Indiana University School of Medicine, Indianapolis, IN, USA
    Circulation 123:2204-12. 2011
    ..We hypothesize that left-sided low-level vagus nerve stimulation (LL-VNS) can suppress sympathetic outflow and reduce atrial tachyarrhythmias in ambulatory dogs...
  57. ncbi Cortical effect and functional recovery by the electromyography-triggered neuromuscular stimulation in chronic stroke patients
    Hwa Kyung Shin
    Department of Physical Therapy, College of Health Science, Catholic University of Daegu, Republic of Korea
    Neurosci Lett 442:174-9. 2008
    ..We demonstrated that 10-week EMG-stim can induce functional recovery and change of cortical activation pattern in the hemiparetic hand of chronic stroke patients...
  58. ncbi Noninvasive brain stimulation with low-intensity electrical currents: putative mechanisms of action for direct and alternating current stimulation
    Soroush Zaghi
    Berenson Allen Center for Noninvasive Brain Stimulation, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Neuroscientist 16:285-307. 2010
    ..Here the authors review what is known about DC and AC stimulation, and they discuss features that remain to be investigated...
  59. ncbi Management of fecal incontinence in adults
    C Norton
    King s College London, Florence Nightingale School of Nursing and Midwifery, London, UK
    Neurourol Urodyn 29:199-206. 2010
    ..The article summarises the evidence and recommendations from the committee for clinical practice and future research...
  60. ncbi Biofeedback and/or sphincter exercises for the treatment of faecal incontinence in adults
    Christine Norton
    Bucks New University and Imperial College HealthcareNHS Trust, Uxbridge, UK
    Cochrane Database Syst Rev 7:CD002111. 2012
    ..However, standards of treatment are still lacking and the magnitude of alleged benefits has yet to be established...
  61. pmc Irritation induced bladder overactivity is suppressed by tibial nerve stimulation in cats
    Changfeng Tai
    Department of Urology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Urol 186:326-30. 2011
    ..We investigated the effects of tibial nerve stimulation on bladder overactivity induced by acetic acid irritation...
  62. ncbi A novel combination of mild electrical stimulation and hyperthermia: general concepts and applications
    Hirofumi Kai
    Department of Molecular Medicine, Graduate School of Pharmaceutical Sciences, Global COE Cell Fate Regulation Research and Education Unit, Kumamoto University, Kumamoto, Japan
    Int J Hyperthermia 25:655-60. 2009
    ..The integrated modalities of MES and hyperthermia might find therapeutic applications to stress-induced diseases and intractable diseases of dysregulated signalling pathways...
  63. ncbi The effects of spinal cord stimulation in neuropathic pain are sustained: a 24-month follow-up of the prospective randomized controlled multicenter trial of the effectiveness of spinal cord stimulation
    Krishna Kumar
    Department of Neurosurgery, Regina General Hospital, Regina, Canada
    Neurosurgery 63:762-70; discussion 770. 2008
    ....
  64. ncbi Peripheral nerve stimulation for trigeminal neuropathic pain
    David A Stidd
    University of Arizona, Tucson, AZ 85724, USA
    Pain Physician 15:27-33. 2012
    ..PNS is a safe procedure that can be performed even on patients that are not optimal surgical candidates and should be considered for patients suffering from TNP that have failed medical management...
  65. ncbi Phenotype of patients responsive to occipital nerve stimulation for refractory head pain
    K Paemeleire
    Department of Neurology, Ghent University Hospital, Ghent, Belgium
    Cephalalgia 30:662-73. 2010
    ..The data suggest medication overuse should be managed appropriately when considering ONS in migraine. A controlled prospective study for ONS in ICHD-II 13.12 is warranted...
  66. ncbi Transcutaneous electrical nerve stimulation combined with task-related training improves lower limb functions in subjects with chronic stroke
    Shamay S M Ng
    Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China
    Stroke 38:2953-9. 2007
    ....
  67. ncbi Transcranial direct current stimulation improves naming reaction time in fluent aphasia: a double-blind, sham-controlled study
    Julius Fridriksson
    Department of Communication Sciences and Disorders, University of South Carolina, 915 Greene Street, Columbia, SC 29201, USA
    Stroke 42:819-21. 2011
    ..The current study further examined this issue in a more tightly controlled experiment in participants with fluent aphasia...
  68. ncbi Transcranial direct current stimulation decreases convulsions and spatial memory deficits following pilocarpine-induced status epilepticus in immature rats
    Tohru Kamida
    Department of Neurosurgery, Oita University Faculty of Medicine, Hasama machi, Oita 879 5593, Japan
    Behav Brain Res 217:99-103. 2011
    ..The effects of cathodal tDCS on convulsions and spatial memory after status epilepticus (SE) in immature animals were investigated...
  69. ncbi Bone bioelectricity: what have we learned in the past 160 years?
    Brad M Isaacson
    Department of Veterans Affairs, Salt Lake City, Utah, USA
    J Biomed Mater Res A 95:1270-9. 2010
    ..It is the purpose of this review to assess the bioelectric phenomenon of bone as it applies to piezoelectricity, fracture healing, and overall changes in bone metabolism which occur with controlled electrical stimulation...
  70. ncbi Trigeminal and occipital peripheral nerve stimulation for craniofacial pain: a single-institution experience and review of the literature
    Konstantin V Slavin
    Department of Neurosurgery, University of Illinois, Chicago, Illinois 60612, USA
    Neurosurg Focus 21:E5. 2006
    ....
  71. ncbi Implanted auriculotemporal nerve stimulator for the treatment of refractory chronic migraine
    Thomas Simopoulos
    Beth Israel Deaconess Medical Center Anesthesia, Boston, MA, USA
    Headache 50:1064-9. 2010
    ..To report a case of improved pain control and function in a patient with chronic migraine after treatment with auriculotemporal nerve stimulation...
  72. ncbi Electrical stimulation of the growth plate: a potential approach to an epiphysiodesis
    George R Dodge
    Bone and Cartilage Research Laboratory, Nemours Biomedical Research, and Department of Orthopaedics, Alfred I duPont Hospital for Children, Nemours Children s Clinic, Wilmington, Delaware
    Bioelectromagnetics 28:463-70. 2007
    ....
  73. ncbi Triple target treatment (3T) is more effective than biofeedback alone for anal incontinence: the 3T-AI study
    Thilo Schwandner
    Clinic for General, Visceral, Thorax, and Transplantation Surgery, Faculty of Medicine, Justus Liebig University Giessen, Giessen, Germany
    Dis Colon Rectum 53:1007-16. 2010
    ..Our purpose was to evaluate a novel therapeutic concept, termed triple target treatment, which combines amplitude-modulated medium-frequency stimulation and EMG-biofeedback...
  74. pmc Neuromuscular electrical stimulation improves exercise tolerance in chronic obstructive pulmonary disease patients with better preserved fat-free mass
    Lara Maris Napolis
    Pulmonary Function and Clinical Exercise Physiology Unit SEFICE, Respiratory Division, Department of Medicine, Federal University of Sao Paulo, Sao Paulo, Brazil
    Clinics (Sao Paulo) 66:401-6. 2011
    ..However, it is conceivable that its benefits are more prominent in patients with better-preserved peripheral muscle function and structure...
  75. pmc Intraspinal microstimulation for the recovery of function following spinal cord injury
    Jeremy A Bamford
    Department of Cell Biology and the Centre for Neuroscience, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada
    Prog Brain Res 194:227-39. 2011
    ..We conclude by suggesting improvements in materials and techniques that are needed in preparation for a clinical proof-of-principle and review our current attempts to achieve these...
  76. ncbi Functional electrical stimulation of dorsiflexor muscle: effects on dorsiflexor strength, plantarflexor spasticity, and motor recovery in stroke patients
    Sukanta K Sabut
    School of Medical Science and Technology, Indian Institute of Technology, Kharagpur, India
    NeuroRehabilitation 29:393-400. 2011
    ....
  77. ncbi Treatment of type 2 diabetes using meal-triggered gastric electrical stimulation
    Shai Policker
    MetaCure USA Inc, Orangeburg, NY 10962, USA
    Isr Med Assoc J 11:206-8. 2009
    ..The system is commercially available in Europe and Israel and is in clinical trials in the United States. It has been tested in 132 patients worldwide to date...
  78. ncbi Peripheral nerve stimulator for the treatment of supraorbital neuralgia: a retrospective case series
    S Amin
    Department of Anesthesiology, Rush Medical College at Rush University Medical Center, Chicago, IL 60612, USA
    Cephalalgia 28:355-9. 2008
    ..In selected patients, supraorbital nerve stimulation for the treatment of chronic frontal headaches appears to be efficacious...
  79. ncbi Feasibility of a new application of noninvasive Brain Computer Interface (BCI): a case study of training for recovery of volitional motor control after stroke
    Janis J Daly
    Cognitive and Motor Learning Research Program, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Ohio, USA
    J Neurol Phys Ther 33:203-11. 2009
    ..There are also potential advantages for combining BCI with functional electrical stimulation (FES). We tested the feasibility of combined BCI + FES for motor learning after stroke...
  80. ncbi Posterior root-muscle reflexes elicited by transcutaneous stimulation of the human lumbosacral cord
    Karen Minassian
    Ludwig Boltzmann Institute of Electrical Stimulation and Physical Rehabilitation, Department of Physical Medicine and Rehabilitation, Wilhelminenspital Wien, Montleartstrasse 37, 1171 Vienna, Austria
    Muscle Nerve 35:327-36. 2007
    ..Continuous transcutaneous posterior root stimulation represents a novel, non-invasive, neuromodulative approach for individuals with different neurological disorders...
  81. ncbi Amyotrophic lateral sclerosis: the Midwestern surgical experience with the diaphragm pacing stimulation system shows that general anesthesia can be safely performed
    Raymond P Onders
    Department of Surgery, University Hospitals Case Medical Center, Detroit, MI, USA
    Am J Surg 197:386-90. 2009
    ..This report summarizes the largest series of surgical cases in ALS during multicenter prospective trials of the laparoscopic diaphragm pacing system (DPS) to delay respiratory failure...
  82. pmc Effects of preoperative neuromuscular electrical stimulation on quadriceps strength and functional recovery in total knee arthroplasty. A pilot study
    Raymond J Walls
    Department of Orthopaedic Surgery, Cappagh National Orthopaedic Hospital, Finglas, Dublin, Ireland
    BMC Musculoskelet Disord 11:119. 2010
    ....
  83. ncbi Epidural spinal cord stimulation plus quipazine administration enable stepping in complete spinal adult rats
    Yury P Gerasimenko
    Department of Physiological Science, University of California, Los Angeles, CA 90095, USA
    J Neurophysiol 98:2525-36. 2007
    ..Quipazine potentiated the amplitude of these responses. The data suggest that there are fundamental differences in the circuitry that generates flexion and extension during locomotion...
  84. ncbi Induction of cortical plastic changes in wrist muscles by paired associative stimulation in the recovery phase of stroke patients
    Evelyne Castel-Lacanal
    Universités de Toulouse, IFR 96, Pôle Santé, Société, Réadaptation, Hopitaux de Toulouse, INSERM U 825, France
    Neurorehabil Neural Repair 23:366-72. 2009
    ....
  85. ncbi Occipital nerve stimulation for drug-resistant chronic cluster headache: a prospective pilot study
    Delphine Magis
    Headache Research Unit, Department of Neurology, Liege University, CHR Citadelle, Liege, Belgium
    Lancet Neurol 6:314-21. 2007
    ..Occipital nerve stimulation (ONS) is a new, safe strategy for intractable headaches. We undertook a prospective pilot trial of ONS in drCCH to assess clinical efficacy and pain perception...
  86. ncbi Low-frequency rectangular pulse is superior to middle frequency alternating current stimulation in cycling of people with spinal cord injury
    Johann Szecsi
    Center for Sensorimotor Research, Department of Neurology, Ludwig Maximillians University, Munich, Germany
    Arch Phys Med Rehabil 88:338-45. 2007
    ....
  87. pmc A novel functional electrical stimulation treatment for recovery of hand function in hemiplegia: 12-week pilot study
    Jayme S Knutson
    Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio 44109, USA
    Neurorehabil Neural Repair 23:17-25. 2009
    ..A previous pilot study showed reductions in hand impairment after 6 weeks of CCFES, but the effect did not persist after end of treatment...
  88. ncbi Neuromuscular electrical stimulation improves severe hand dysfunction for individuals with chronic stroke: a pilot study
    Marcio Santos
    Landon Center on Aging, Kansas University Medical Center, USA
    J Neurol Phys Ther 30:175-83. 2006
    ..NMES-assisted grasping trended towards greater functional benefit than traditional NMES-activation of wrist flexors/extensors...
  89. ncbi Greater occipital nerve stimulation via the Bion microstimulator: implantation technique and stimulation parameters. Clinical trial: NCT00205894
    Terrence L Trentman
    Department of Anesthesiology, Mayo Clinic Arizona, Scottsdale, AZ 85054, USA
    Pain Physician 12:621-8. 2009
    ..Millions of patients suffer from medically refractory and disabling primary headache disorders. This problem has led to a search for new and innovative treatment modalities, including neuromodulation of the occipital nerves...
  90. ncbi Hybrid power-assisted functional electrical stimulation to improve hemiparetic upper-extremity function
    Yukihiro Hara
    Department of Rehabilitation Medicine, Nippon Medical School, Chiba Hokusoh Hospital, Japan
    Am J Phys Med Rehabil 85:977-85. 2006
    ..The effect on spastic hemiparesis of a hybrid therapy consisting of functional electrical stimulation and block therapy was examined...
  91. ncbi Pulsed electrical stimulation for control of vasculature: temporary vasoconstriction and permanent thrombosis
    Daniel Palanker
    Department of Ophthalmology, Stanford University School of Medicine, Stanford, California 94305 4085, USA
    Bioelectromagnetics 29:100-7. 2008
    ..Histology demonstrated a lack of tissue damage during vasoconstriction, but vascular endothelium was damaged during thrombosis. The temperature increase does not exceed 0.1 degrees C during these treatments...
  92. ncbi Peripheral neurostimulation for treatment of intractable occipital neuralgia
    Konstantin V Slavin
    Department of Neurosurgery, University of Illinois, Chicago, Illinois 60612, USA
    Neurosurgery 58:112-9; discussion 112-9. 2006
    ..Peripheral nerve stimulation (PNS) may serve as a good alternative to destructive surgical manipulations used currently for the treatment of severe ON...
  93. ncbi Peripheral neurostimulation for the treatment of refractory cluster headache, long-term follow-up: case report
    Antonios Mammis
    Department of Neurosurgery, Cushing Neuroscience Institutes, Hofstra University School of Medicine and North Shore University Hospital, Manhasset, New York, USA
    Neuromodulation 14:432-5; discussion 435. 2011
    ..There are recent reports utilizing occipital nerve stimulation for the successful management of medically refractory cases of cluster headache...
  94. ncbi Stimulation parameter optimization for FES supported standing up and walking in SCI patients
    Manfred Bijak
    Department of Biomedical Engineering and Physics, Medical University of Vienna, Vienna, Austria
    Artif Organs 29:220-3. 2005
    ..1-0.2 s. Activation of adductor muscles during standing up and during the swing phase helps to avoid hip abduction and improves knee trajectories...
  95. ncbi Effect of an external responsive neurostimulator on seizures and electrographic discharges during subdural electrode monitoring
    Eric H Kossoff
    Department of Pediatrics and Neurology, Johns Hopkins Hospital, Baltimore, Maryland 21287 1000, USA
    Epilepsia 45:1560-7. 2004
    ..Approved neural-stimulation therapies for epilepsy use prolonged intermittent stimulation paradigms with no ability to respond automatically to seizures...
  96. ncbi Preemptive low-frequency stimulation decreases the incidence of amygdala-kindled seizures
    Jeffrey H Goodman
    CNRRR, Helen Hayes Hospital, West Haverstraw, New York 10993, USA
    Epilepsia 46:1-7. 2005
    ..This study examined the effect of preemptive, low-frequency, 1-Hz sine wave stimulation (LFS) on the incidence of amygdala-kindled seizures in the rat...
  97. ncbi Cycling induced by electrical stimulation improves motor recovery in postacute hemiparetic patients: a randomized controlled trial
    Emilia Ambrosini
    Politecnico di Milano, Piazza Leonardo da Vinci 32, 20133, Milano, Italy
    Stroke 42:1068-73. 2011
    ..This study assessed whether cycling induced by functional electrical stimulation (FES) was more effective than passive cycling with placebo stimulation in promoting motor recovery and walking ability in postacute hemiparetic patients...
  98. ncbi The efficacy of a new stimulation technology to increase venous flow and prevent venous stasis
    M Griffin
    The Vascular Noninvasive Screening and Diagnostic Centre, 30 Weymouth Street, London W1G 7BS, UK
    Eur J Vasc Endovasc Surg 40:766-71. 2010
    ..The aim was to determine: (a) dependence of venous blood velocity and ejected volume on the rates of stimulated calf contractions: (b) clinical factors affecting efficacy in healthy individuals...
  99. ncbi Low-level vagosympathetic stimulation: a paradox and potential new modality for the treatment of focal atrial fibrillation
    Shuyan Li
    Department of Cardiology, The Second Hospital of Jilin University, Jilin, China
    Circ Arrhythm Electrophysiol 2:645-51. 2009
    ..This study was designed to demonstrate that bilateral low-level vagosympathetic nerve stimulation (LL-VNS) could suppress high-frequency stimulation-induced focal AF at atrial and PV sites...
  100. ncbi [Stimulation of the occipital nerve in the treatment of drug-resistant cluster headache]
    Cristian de Quintana-Schmidt
    Servicio de Neurocirugia, Hospital de la Santa Creu i Sant Pau, 08025 Barcelona, Espana
    Rev Neurol 51:19-26. 2010
    ..To evaluate the occipital nerve stimulation therapy in as a treatment for drug-resistant cluster headache...
  101. ncbi A clinical trial of neuromuscular electrical stimulation in improving quadriceps muscle strength and activation among women with mild and moderate osteoarthritis
    Riann M Palmieri-Smith
    School of Kinesiology, University of Michigan, 4745G CCRB, 401 Washtenaw Ave, Ann Arbor, MI 48109, USA
    Phys Ther 90:1441-52. 2010
    ..Yet, data are lacking to establish the efficacy of NMES in people with evidence of early radiographic osteoarthritis...

Research Grants72

  1. Locomotion Control by Lumbar Spinal Cord Stimulation
    Changfeng Tai; Fiscal Year: 2008
    ..The proposed studies will not only improve our understanding of locomotion control in lumbar spinal cord but also benefit SCI patients. ..
  2. Bladder and Sphincter Control after Spinal Cord Injury
    Changfeng Tai; Fiscal Year: 2008
    ..abstract_text> ..
  3. Neuro-Musculoskeletal Plasticity after SCI
    Richard K Shields; Fiscal Year: 2010
    ..The proposed method not only has excellent potential for efficacy, but is also likely to be economical and easily integrated into the daily lives of people with SCI. ..
  4. Beaumont Interstitial Cystitis Clinical Research Network
    Kenneth Peters; Fiscal Year: 2007
    ..Adverse events and complications will be monitored. Ancillary studies as agreed upon by the ICCRN will be carried out in conjunction with the clinical trial. ..
  5. MUSCULOSKELETAL PLASTICITY AFTER SPINAL CORD INJURY
    RICHARD SHIELDS; Fiscal Year: 2003
    ..The benefits of this newly developed adaptive feedback controlled exercise may provide a standard that individuals with paralysis may use in an effort to maintain their musculoskeletal properties following paralysis. ..
  6. Electrical stimulation for upper limb recovery in stroke
    John Chae; Fiscal Year: 2008
    ..2. Assess the effect of NMES on upper limb activity limitation. 3. Assess the effect of NMES on central motor processing. 4. Assess the effect of adding cognitive input during NMES therapy. ..
  7. BION Treatment of Neuromuscular Dysfunction
    Gerald Loeb; Fiscal Year: 2006
    ..abstract_text> ..
  8. Pharmacotherapy for Minor Depression
    Robert Howland; Fiscal Year: 2004
    ..The results of this study will have profound public health implications by improving our understanding of the efficacy of SJW and standard antidepressants for the treatment of MinorD. ..
  9. DBS and Rodent Antidepressant- Screen Models
    Ziad Nahas; Fiscal Year: 2008
    ..Future work will bridge between validating these findings in more comprehensive models of depression and clinical investigations of the DBS antidepressant effect in patients with treatment resistant depression. ..
  10. Subacute Stroke Recovery: Bimanual Coordination Training
    James Cauraugh; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  11. ELECTROSTIMULATION FOR HEMIPLEGIA
    John Chae; Fiscal Year: 2004
    ..EMG-controlled NIMES may also be effective for lower extremity motor and functional recovery. ..
  12. Enhancing Neuroprosthesis Performance with Nerve Cuff Electrodes
    Ronald J Triolo; Fiscal Year: 2010
    ....
  13. Electrical Stimulation for Hemiplegic Shoulder Pain
    John Chae; Fiscal Year: 2010
    ..We further postulate that ES improves glenohumeral stability by facilitating motor recovery. Thus we will evaluate the effects of these treatments on objective measures of poststroke motor recovery. ..
  14. ELECTROSTIMULATION FOR STROKE REHAB: EFFECTS & MECHANISM
    John Chae; Fiscal Year: 2002
    ..Finally, techniques developed for assessing central motor function may be useful for evaluating other interventions directed at stroke rehabilitation. ..
  15. MOOD EFFECTS OF DEEP BRAIN STIMULATION IN PARKINSONS
    Mark George; Fiscal Year: 2002
    ..Thus, we plan to use interleaved fMRI and DBS to directly examine the effects of DBS on hypothesized brain circuits and to correlate this with immediate and longer-term (4 week) behavioral outcomes (mood and cognition). ..
  16. A Novel Waveform for Electrical Nerve Conduction Block
    Kevin Kilgore; Fiscal Year: 2002
    ..The initial intended human application will be to alleviate pain in individuals with neuromas secondary to limb amputation. ..
  17. INJECTABLE SENSORS FOR CONTROL OF FES
    Gerald Loeb; Fiscal Year: 2002
    ....
  18. IMPLANTED NEUROPROSTHESIS FOR STANDING AFTER SCI
    Ronald Triolo; Fiscal Year: 2006
    ..Abstract Not Provided ..
  19. Optimization of TMS for Depression - Coordinating Center
    Mark George; Fiscal Year: 2009
    ..This coordinating Center Grant (CCG) application is submitted under a CSMD mechanism, linked to 4 clinical site grants (CSG). ..
  20. FES for foot-drop in hemiparesis
    John Chae; Fiscal Year: 2009
    ..This proposed approach is expected to improve patient outcome and challenge the present clinical paradigm of prescribing AFOs for stroke survivors with foot-drop. ..
  21. Optimization of TMS for Depression
    Mark George; Fiscal Year: 2009
    ..This clinical site grant (CSG) proposal is one of four scientifically identical proposals resubmitted under a CSMD mechanism.] ..
  22. BION Treatment of Neuromuscular Dysfunction
    Gerald Loeb; Fiscal Year: 2002
    ..abstract_text> ..
  23. Mechanisms of Vaginal Sling Effects on Continence
    Firouz Daneshgari; Fiscal Year: 2006
    ..The long-term goal of this proposal is to expand the findings of this project into an R01 application in order to translate our findings into relevant clinical studies. [unreadable] [unreadable]..
  24. Conference--National Urology Resident Female Pelvic Med
    Firouz Daneshgari; Fiscal Year: 2006
    ..abstract_text> ..
  25. Assessment of Altered Function in Diabetic Bladder
    Firouz Daneshgari; Fiscal Year: 2005
    ....
  26. A Novel Waveform for Electrical Nerve Conduction Block
    Kevin L Kilgore; Fiscal Year: 2010
    ..This research will provide a significant tool in our ongoing efforts to reduce disability and improve quality of life. ..
  27. PKC ALTERATIONS IN LUT DYSFUNCTION
    Firouz Daneshgari; Fiscal Year: 2004
    ..abstract_text> ..
  28. MODEL FOR ELECTRODE TESTING AND REDUCED ANIMAL USE
    Stuart Cogan; Fiscal Year: 2003
    ..The validity of the inanimate and living models will be evaluated by comparison of electrode function in the in vitro models with that observed under identical test protocols in the chronic cat cortex. ..
  29. Conductive Polymer Recording and Stimulation Electrodes
    Stuart Cogan; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  30. Functionalized Coatings for Enhanced Neural Interfaces
    Stuart Cogan; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  31. Adaptation to controlled vestibular stimulation
    DANIEL MERFELD; Fiscal Year: 2005
    ..All of these proposed specific aims will be investigated by measuring changes in the vestibulo-ocular responses induced by changes in chronic, patterned, electrical stimulation of the peripheral vestibular system. ..
  32. Recovery of Function and Vagus Nerve Stimulation
    Douglas Smith; Fiscal Year: 2005
    ..abstract_text> ..
  33. DRUG SENSITIVITY IN ELDERLY PSYCHIATRIC PATIENTS
    Ian Cook; Fiscal Year: 2002
    ..Cook will be well prepared to undertake independent and collaborative investigations, to expand his teaching roles, and to play a role in bridging basic science and clinical research within the Department. ..
  34. Development of an electrical diagnostic for melanoma
    Richard Nuccitelli; Fiscal Year: 2008
    ..If the handheld BFI is able to reliably detect malignant skin lesions, it will improve the quality of life for tens of thousands of dermatology patients in the United States alone. [unreadable] [unreadable] [unreadable]..
  35. CAM CLINICAL RESEARCH CURRICULUM PROGRAM
    Ann Taylor; Fiscal Year: 2004
    ..Based upon prior successes in conventional research training, the faculty can guarantee that CAM trainees will acquire the needed knowledge and shills for successful careers in CAM research. ..
  36. Development of semicircular canal prostheses for studies of vestibular plasticity
    DANIEL MERFELD; Fiscal Year: 2009
    ..abstract_text> ..
  37. Development of a nanosecond pulsed electric field system to treat skin cancer
    Richard Nuccitelli; Fiscal Year: 2008
    ..It offers a scar-free alternative to surgery that could improve the quality of life for tens of thousands of dermatology patients. [unreadable] [unreadable] [unreadable]..
  38. TMS in the Management of Postoperative Pain
    Jeffrey J Borckardt; Fiscal Year: 2010
    ..Thus, new interventions that have the potential to reduce reliance on postoperative morphine in this patient population such as TMS need to be explored. ..
  39. Development of an Inventory of Depressive Symptomatology
    AUGUSTUS RUSH; Fiscal Year: 2005
    ..g., anxiety, irritability) (IDS-C and SR) that are in the public domain for use with patients across the age spans seen in practice and in research. ..
  40. Massage to Enhance Quality of Life in ASCT Patients
    Ann Taylor; Fiscal Year: 2005
    ..These analyses will provide the foundation for designing a large multi-site RCT (R01) that will examine the effects and mechanisms of massage therapy for patients with cancer undergoing ASCT ..
  41. PACING, SENSING AND DEFIBRILLATION ELECTRODE COATINGS
    Stuart Cogan; Fiscal Year: 2006
    ..The in vivo studies will be done with collaborators at the University of Alabama. [unreadable] [unreadable]..
  42. Functional Impact of PENS for 65+ Chronic Low Back Pain
    Debra Weiner; Fiscal Year: 2006
    ....
  43. Osteopuncture for OA-Associated Knee Pain & Disability
    Debra Weiner; Fiscal Year: 2005
    ..In addition, mechanisms of action will be explored, and the impact of osteopuncture on health care costs determined. ..
  44. Electrodeposited Noble Metal Oxide Nerve Electrodes
    Stuart Cogan; Fiscal Year: 2006
    ..abstract_text> ..
  45. Pulsed Electron Avalanche Knife: Intraocular Microsurg.
    Daniel Palanker; Fiscal Year: 2006
    ..The low cost and small size of this system combined with high precision, reliability and versatility should allow for a widespread acceptance into operating practice. ..
  46. RESPONSE VARIABILITY IN TREATMENT RESISTANT DEPRESSION
    Ian Cook; Fiscal Year: 2006
    ..Secondary analyses will use general linear models and growth mixture modeling to examine how early cordance changes relate to patient and illness factors and to functional outcomes. [unreadable] [unreadable]..
  47. Mental Practice Dosing and Mechanisms in Stroke
    Stephen Page; Fiscal Year: 2006
    ..Identification of MP mechanisms of action and optimal dosing is fundamental to cost-effective, appropriate implementation of this promising, CAM, mind-body technique, and will enable a subsequent MP clinical trial. ..
  48. Characterizing Sympathetic Transduction in Humans
    J Taylor; Fiscal Year: 2006
    ..abstract_text> ..
  49. Calibration Tools For PC-Based Vision Enhancement
    Gislin Dagnelie; Fiscal Year: 2008
    ..Project Description Page 7 ..
  50. Mediators of Blood-Brain Barrier Disruption
    Damir Janigro; Fiscal Year: 2007
    ..g. Alzheimer's, demyelinating diseases, brain tumors). [unreadable] [unreadable]..
  51. ACTIVITY-DEPENDENT PLASTICITY AFTER SPINAL CORD INJURY
    Andrea Behrman; Fiscal Year: 2004
    ..abstract_text> ..
  52. Multimodal Pediatric Motor Recovery System
    JOSEPH GIUFFRIDA; Fiscal Year: 2005
    ..abstract_text> ..
  53. BIOPHYSICAL DETERMINANTS OF DIABETIC FOOT ULCER HEALING
    Charles Saltzman; Fiscal Year: 2003
    ..Three-dimensional rate of ulcer healing will be measured with stereophotography and computerized image analysis techniques. ..
  54. PharmaScan 70/16 In-Vivo Spectroscopy/Imaging System
    Ranu Jung; Fiscal Year: 2005
    ..abstract_text> ..
  55. A TREATMENT FOR EXCESS MOTOR DISABILITY IN THE AGED
    Edward Taub; Fiscal Year: 2007
    ..abstract_text> ..
  56. VIRTUAL STROKE MODEL FOR STUDY OF BLADDER HYPERREFLEXIA
    Victor Pikov; Fiscal Year: 2005
    ..We hope that this project can lead to development of a better treatment of stroke-related bladder dysfunction. ..
  57. Spinal Cord Computer Interface
    Mesut Sahin; Fiscal Year: 2008
    ..The average life expectance of this population is 40 years. Any tool or instrument that can provide them with self-mobility, environmental control, and computer access is priceless. [unreadable] [unreadable] [unreadable]..
  58. Neonatal Intensive Care Unit Telemetry System
    JOSEPH GIUFFRIDA; Fiscal Year: 2006
    ..Significant verification and validation testing will ensure that all applicable standards are met. Finally a large clinical trial will be completed with neonatal subjects to ensure clinical efficacy. [unreadable] [unreadable]..
  59. Spinal hierarchy and noxious cardiac sensory processing
    Robert Foreman; Fiscal Year: 2007
    ..These studies will provide a basis for determining the impact of C1-C2 neurons on the hierarchy of cardiac control. [unreadable] [unreadable]..
  60. NUMERICAL SIMULATION OF CARDIAC ELECTROPHYSIOLOGY
    Bradley Roth; Fiscal Year: 2005
    ..Each hypothesis is motivated by experimental data, and the goal of the theoretical simulations is to interpret these data. ..
  61. Randomized Controlled Trial of Pediatric CI Therapy
    Edward Taub; Fiscal Year: 2006
    ..abstract_text> ..
  62. CRCNS: Modeling Neuromusculoskeletal Alterations after Spinal Cord Injury
    Ranu Jung; Fiscal Year: 2008
    ..abstract_text> ..
  63. Bone Fluid Flow and its Regulatory Role in Adaptation
    Yi Xian Qin; Fiscal Year: 2006
    ..abstract_text> ..
  64. Role of Musculo-Dynamics in Bone Fluid Flow, Circulation and Adaptation
    Yi Xian Qin; Fiscal Year: 2009
    ..Ultrastructural osteoblastic features of cell and nuclei will be examined via histomorphometric analysis of cell area, nuclear area, cell number, cell and nuclei shapes, in which associated fluid components will be identified. ..
  65. A Rodent Model for Locomotor Training with FNS
    Ranu Jung; Fiscal Year: 2004
    ..This locomotor training could also be combined with pharmacological intervention, tissue transplant, and neural repair therapies to determine if locomotor training can enhance the effectiveness of these therapies. ..
  66. Active MEMS Neural Clamps
    Ranu Jung; Fiscal Year: 2006
    ..Such electrodes will advance our capabilities of scientific investigation of neural function in awake subjects and in the development of advanced neuroprosthetic products for rehabilitation. ..
  67. The 6th International Bone Fluid Flow Workshop
    Yi Xian Qin; Fiscal Year: 2004
    ..Cellular and Molecular Response to Fluid Flow Stimulation 4. The role of fluid flow in tissue engineering 5. Physiological mechanism and clinical implications of bone fluid flow. ..
  68. Effects of Bromocriptine on Aphasia Treatment Outcome
    Leora Cherney; Fiscal Year: 2003
    ..Language performance will also be measured at three and six months after completion of treatment to answer the secondary questions regarding maintenance of language improvements. ..
  69. Mechanisms of Myocardial Radiofrequency Scar Expansion
    Rupak Mukherjee; Fiscal Year: 2004
    ..abstract_text> ..
  70. Phase resetting using DC stimulation for seizure blockage
    Ivan Osorio; Fiscal Year: 2007
    ..3B. The significant advances made in the control of fatal arrhythmias are in part attributable to the use by cardiologists of phase resetting as an investigative and therapeutic tool. [unreadable] [unreadable] [unreadable]..
  71. Imaging Predictors of Treatment Response for Depression
    Helen Mayberg; Fiscal Year: 2009
    ..Identification of such biomarkers has additional implications for future testing of novel therapies in patients with distinct brain signatures, including development of evidence-based treatment algorithms for individual patients. ..